Dr Gaia Pasqualetto
Research Assistant
Ysgol y Biowyddorau
Cyhoeddiad
2023
- Pasqualetto, G. et al. 2023. CryoEM structure and Alphafold molecular modelling of a novel molluscan hemocyanin. PLoS ONE 18(6), article number: e0287294. (10.1371/journal.pone.0287294)
- Pasqualetto, G., Zuanon, M., Brancale, A. and Young, M. T. 2023. Identification of the molecular determinants of antagonist potency in the allosteric binding pocket of human P2X4. Frontiers in Pharmacology 14 (10.3389/fphar.2023.1101023)
- Pasqualetto, G., Zuanon, M., Brancale, A. and Young, M. T. 2023. Identification of a novel P2X7 antagonist using structure-based virtual screening. Frontiers in Pharmacology 13, article number: 1094607. (10.3389/fphar.2022.1094607)
2022
- Picarazzi, F. et al. 2022. Identification of small molecular chaperones binding p23h mutant opsin through an in silico structure-based approach. Journal of Chemical Information and Modeling 62(22), pp. 5794-5805. (10.1021/acs.jcim.2c01040)
2021
- Pasqualetto, G., Pileggi, E., Schepelmann, M., Varricchio, C., Rozanowska, M., Brancale, A. and Bassetto, M. 2021. Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin. European Journal of Medicinal Chemistry 226, article number: 113841. (10.1016/j.ejmech.2021.113841)
2020
- Grimes, L., Griffiths, J., Pasqualetto, G., Brancale, A., Kemp, P. J., Young, M. T. and van der Goes van Naters, W. 2020. Drosophila taste neurons as an agonist-screening platform for P2X receptors. Scientific Reports 10, article number: 8292. (10.1038/s41598-020-65169-9)
- Pasqualetto, G. et al. 2020. Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins. Molecules 25(21), article number: 4904. (10.3390/molecules25214904)
2019
- Giancotti, G. et al. 2019. A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase. Scientific Reports 9(1), article number: 18413. (10.1038/s41598-019-54903-7)
- Pasqualetto, G. et al. 2019. Novel small-molecule chaperones to overcome opsin misfolding, mistrafficking and aggregation in retinal blinding diseases. Presented at: 2019 ARVO Annual Meeting, Vancouver, Canada, 28 April - 02 May 2019Investigative ophthalmology & visual science, Vol. 60. Vol. 9. ARVO
- Pileggi, E., Pasqualetto, G., Rozanowska, M., Brancale, A. and Bassetto, M. 2019. Development of novel treatments against inherited blinding diseases Retinitis pigmentosa and Leber's congenital amaurosis [Abstract]. Abstracts of Papers of the American Chemical Society 257, article number: 318.
2018
- Pasqualetto, G. 2018. Structure-based design of P2X receptor small molecule modulators. PhD Thesis, Cardiff University.
- Pasqualetto, G., Brancale, A. and Young, M. T. 2018. The molecular determinants of small-molecule ligand binding at P2X receptors. Frontiers in Pharmacology 9, article number: 58. (10.3389/fphar.2018.00058)
2014
- Anthopoulos, A., Pasqualetto, G., Grimstead, I. and Brancale, A. 2014. Haptic-driven, interactive drug design: implementing a GPU-based approach to evaluate the induced fit effect. Faraday Discussions 169, pp. 323-342. (10.1039/C3FD00139C)
Articles
- Pasqualetto, G. et al. 2023. CryoEM structure and Alphafold molecular modelling of a novel molluscan hemocyanin. PLoS ONE 18(6), article number: e0287294. (10.1371/journal.pone.0287294)
- Pasqualetto, G., Zuanon, M., Brancale, A. and Young, M. T. 2023. Identification of the molecular determinants of antagonist potency in the allosteric binding pocket of human P2X4. Frontiers in Pharmacology 14 (10.3389/fphar.2023.1101023)
- Pasqualetto, G., Zuanon, M., Brancale, A. and Young, M. T. 2023. Identification of a novel P2X7 antagonist using structure-based virtual screening. Frontiers in Pharmacology 13, article number: 1094607. (10.3389/fphar.2022.1094607)
- Picarazzi, F. et al. 2022. Identification of small molecular chaperones binding p23h mutant opsin through an in silico structure-based approach. Journal of Chemical Information and Modeling 62(22), pp. 5794-5805. (10.1021/acs.jcim.2c01040)
- Pasqualetto, G., Pileggi, E., Schepelmann, M., Varricchio, C., Rozanowska, M., Brancale, A. and Bassetto, M. 2021. Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin. European Journal of Medicinal Chemistry 226, article number: 113841. (10.1016/j.ejmech.2021.113841)
- Grimes, L., Griffiths, J., Pasqualetto, G., Brancale, A., Kemp, P. J., Young, M. T. and van der Goes van Naters, W. 2020. Drosophila taste neurons as an agonist-screening platform for P2X receptors. Scientific Reports 10, article number: 8292. (10.1038/s41598-020-65169-9)
- Pasqualetto, G. et al. 2020. Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins. Molecules 25(21), article number: 4904. (10.3390/molecules25214904)
- Giancotti, G. et al. 2019. A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase. Scientific Reports 9(1), article number: 18413. (10.1038/s41598-019-54903-7)
- Pileggi, E., Pasqualetto, G., Rozanowska, M., Brancale, A. and Bassetto, M. 2019. Development of novel treatments against inherited blinding diseases Retinitis pigmentosa and Leber's congenital amaurosis [Abstract]. Abstracts of Papers of the American Chemical Society 257, article number: 318.
- Pasqualetto, G., Brancale, A. and Young, M. T. 2018. The molecular determinants of small-molecule ligand binding at P2X receptors. Frontiers in Pharmacology 9, article number: 58. (10.3389/fphar.2018.00058)
- Anthopoulos, A., Pasqualetto, G., Grimstead, I. and Brancale, A. 2014. Haptic-driven, interactive drug design: implementing a GPU-based approach to evaluate the induced fit effect. Faraday Discussions 169, pp. 323-342. (10.1039/C3FD00139C)
Conferences
- Pasqualetto, G. et al. 2019. Novel small-molecule chaperones to overcome opsin misfolding, mistrafficking and aggregation in retinal blinding diseases. Presented at: 2019 ARVO Annual Meeting, Vancouver, Canada, 28 April - 02 May 2019Investigative ophthalmology & visual science, Vol. 60. Vol. 9. ARVO
Thesis
- Pasqualetto, G. 2018. Structure-based design of P2X receptor small molecule modulators. PhD Thesis, Cardiff University.