Ewch i’r prif gynnwys
Helen Pearson

Dr Helen Pearson

Senior Research Fellow

Ysgol y Biowyddorau

+44 29206 88517
Adeilad Hadyn Ellis, Heol Maendy, Caerdydd, CF24 4HQ
Ar gael fel goruchwyliwr ôl-raddedig


Prostate Cancer Translational Research Laboratory

European Cancer Stem Cell Research Institute, Cardiff University, Department of Biomedicine, School of Biosciences, Cardiff University

Prostate cancer arises from multiple complex cellular processes that remain to be fully understood. Dr Pearson’s research into prostate cancer integrates basic molecular and cellular biology with preclinical trials to advance our understanding of prostate cancer biology, and to translate laboratory studies into improvements in patient care and outcome. To address this, the research undertaken incorporates the development and application of innovative preclinical model systems in collaboration with researchers, clinicians and industry.
















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My research into prostate cancer integrates basic cancer biology, biomarker discovery and the preclinical assessment of novel therapeutic approaches with the ultimate goal to improve upon the current standard of patient care. The research undertaken employs novel model systems to investigate genetic drivers of prostate cancer initiation and progression, and the preclinical development of innovative therapeutic strategies for prostate cancer.

Current projects and/or themes

  • Determining how the non-canonical WNT pathway contributes to prostate cancer
  • Delineating molecular mechanisms of resistance to androgen-deprivation therapy
  • Enhancing the therapeutic efficacy of PARP inhibition for the treatment of prostate cancer
  • Development of ex-vivo models for prostate cancer
  • Development of PDX models of prostate cancer
  • Prostate cancer stem cells and the tumor microenvironment
  • Exploring how PI3K signaling contributes to prostate cancer
  • Targeting Wnt signaling to treat metastatic prostate cancer

Current grant support

  • Knowledge Economy Skills Scholarships (KESS2)/Tenovus Cancer Care (2017 - 2021)
  • The Urology Foundation (2018 - 2021)
  • Cancer Research UK (2020 - 2026)


  • Prof Wayne Phillips (Peter MacCallum Cancer Centre, Melbourne, Australia)
  • Prof Owen Sansom (CRUK Beatson Institute, Glasgow, UK)
  • Prof Howard Kynaston (University Hospital Wales, Cardiff University, UK)
  • Prof John Staffurth (Rutherford Cancer Centre South Wales, UK)
  • Prof Gail Risbridger (Monash University, Melbourne, Australia)
  • Prof Johann de Bono (ICR, London, UK)
  • Prof Norman Maitland (York University, York, UK)

Research Staff

  • Dr Daniel Turnham
  • Miss Sarah Martin
  • Miss Kate Mason

Postgraduate Students

  • Miss Manisha Dass – KESS2/Tenovus Cancer Care PhD student
  • Mr Nicholas Bullock – Wales Clinical Academic Track (WCAT) fellow (PhD Student)


Please enquire about our current posts:

  • PhD studentship available
  • Clinical PhD student positions available


Undergraduate teaching

  • BI3352: Cancer: Molecular mechanisms, diagnostics and therapeutics (module coordinator/examiner for assessed coursework 1/small group teaching sessions)
  • Module co-coordinator/lecturer: Cancer research: from concepts to experimental models to translational research (Year 2, week long practical).
  • BI2233: Developmental and stem cell biology, Lecturer (workshops)
  • Principle supervisor for final year honours project students


Education and qualifications

I am a Cancer Research UK Research Fellow at the European Cancer Stem Cell Research Centre, Cardiff University. I graduated from the University of East Anglia in 2004 with a BSc in Biochemistry, following an exchange year at Colorado University (Boulder, USA). In 2004, I undertook my PhD at Cardiff University, where I developed several new models of prostate cancer, and moved to Australia to commence my post-doctoral training at the Peter MacCallum Cancer Centre in Australia. In 2012, I became an honorary fellow of Melbourne University and the inaugural Richard Pratt Foundation Fellow for prostate cancer research. In 2016, I returned to Cardiff University as a Marie Sklodowska-Curie Actions COFUND research fellow and was awarded a Cancer Research Career Development Fellowship in 2019, enabling me to build my research group investigating the molecular mechanisms that underpin prostate cancer growth and therapeutic resistance. This knowledge is applied to the development of novel and more effective biomarkers and therapeutic approaches for prostate cancer.

Anrhydeddau a dyfarniadau

  • 2020 - NCRI Bursary Prize
  • 2016 – 2020: Marie Slodowska Curie Actions/Horizon2020/Ser Cymru II Fellowship
  • 2013 – 2014: Richard Pratt Foundation Prostate Cancer Research Fellowship/Victorian Cancer Agency

Aelodaethau proffesiynol

  Cymdeithas Ymchwil Bôn-gelloedd Awstralia (ASSCR)
2014  Grŵp treialon clinigol Wrogenol a Phrostad Awstralia a Seland Newydd (ANZUP)
2010  Cynghrair Ymchwil Canser y Prostad Awstralia a Chanada (AC-PCRA)
2005  Cymdeithas Ewropeaidd ar gyfer Ymchwil Canser (EACR)
Cymdeithas Ymchwil Canser Prydain (BACR) 2005  
2004  Cymdeithas Frenhinol Bioleg (RSB)

Safleoedd academaidd blaenorol

2016 – present: Research Fellow, European Cancer Stem Cell Research Centre, Cardiff University, Wales, UK
2012 – 2016:     Senior Research Officer, Peter MacCallum Cancer Centre, Melbourne, Australia
2012 – 2016:     Honorary Fellow, University of Melbourne, The Sir Peter MacCallum Department of Oncology, Melbourne, Australia
2008 – 2012:     Junior Research Officer, Peter MacCallum Cancer Centre, Melbourne,  Australia

Pwyllgorau ac adolygu

  • Golygydd Gwadd Cyfnodolion, Biomolecules
  • Golygydd Cyfnodolion, British Journal of Cancer
  • Adolygydd cyfnodolyn, Cancer Discovery
  • Adolygydd Cyfnodolion, Cyfathrebu Natur
  • Adolygydd cyfnodolyn, Modelau Clefydau a Mecanweithiau
  • Adolygydd cyfnodolyn, Cell Death and Disease
  • Adolygydd cyfnodolyn, Oncogene
  • Adolygydd cyfnodolyn, Molecular Cancer

Meysydd goruchwyliaeth


Ar hyn o bryd rwyf ar gael i oruchwylio myfyrwyr ymchwil ôl-raddedig (PhD, MRes, MSc).

Mae gen i ddiddordeb mewn goruchwylio myfyrwyr PhD ym meysydd:

  • Bioleg foleciwlaidd canser y prostad
  • Treialon cyn-glinigol ar gyfer canser y prostad
  • Ymwrthedd therapiwtig mewn canser y prostad
  • Metastasis