![James Pearson](https://profiles-cardiff.imgix.net/attachments/2547?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Trosolwyg
Rwyf wedi bod yn gwneud ymchwil ym maes imiwnoleg diabetes math 1 (T1D) ers 2011. Mae fy ymchwil yn canolbwyntio ar ddeall sut y gellir addasu celloedd imiwnedd i leihau tueddiad i T1D gyda'r nod o ddatblygu meysydd ymchwil newydd y gellir eu cyfieithu ar gyfer therapïau T1D ataliol.
Cyhoeddiad
2024
- Haq, N. et al. 2024. Reformed islets: a long-term primary cell platform for exploring mouse and human islet biology. Cell Death Discovery 10, article number: 480. (10.1038/s41420-024-02234-6)
- Wang, P. et al. 2024. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 15(1), article number: 4232. (10.1038/s41467-024-48611-8)
- Pearson, J. A., Hu, Y., Peng, J., Wong, F. S. and Wen, L. 2024. TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model. Frontiers in Immunology 15, article number: 1333967. (10.3389/fimmu.2024.1333967)
2023
- Pearson, J. A. et al. 2023. NLRP6 deficiency expands a novel CD103 + B cell population that confers immune tolerance in NOD mice. Frontiers in Immunology 14, article number: 1147925. (10.3389/fimmu.2023.1147925)
2022
- Boldison, J. et al. 2022. Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes. Diabetologia 66(3), pp. 551-566. (10.1007/s00125-022-05839-7)
- Pearson, J. A. et al. 2022. IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans. Diabetologia 65(8), pp. 1398-1411. (10.1007/s00125-022-05711-8)
- Chan, K., Wong, F. S. and Pearson, J. A. 2022. Circadian rhythms and pancreas physiology: A review. Frontiers in Endocrinology 13, article number: 920261. (10.3389/fendo.2022.920261)
- Pearson, J. A., McKinney, E. F. and Walker, L. S. K. 2022. 100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes. Immunotherapy Advances (10.1093/immadv/ltab024)
- Huang, J., Pearson, J. A., Wong, F. S., Wen, L. and Zhou, Z. 2022. Innate immunity in latent autoimmune diabetes in adults (LADA). Diabetes/Metabolism Research and Reviews 38(1), article number: e3480. (10.1002/dmrr.3480)
2021
- Pearson, J. A., Voisey, A. C., Boest Bjerg, K., Wong, F. S. and Wen, L. 2021. Circadian rhythm modulation of microbes during health and infection. Frontiers in Microbiology 12, article number: 721004. (10.3389/fmicb.2021.721004)
- Huang, J. et al. 2021. IL-10 deficiency accelerates type 1 diabetes development via modulation of innate and adaptive immune cells and gut microbiota in BDC2.5 NOD mice. Frontiers in Immunology 12, article number: 702955. (10.3389/fimmu.2021.702955)
- Pearson, J. A., Wong, F. S. and Wen, L. 2021. Inflammasomes and type 1 diabetes. Frontiers in Immunology 12, article number: 686956. (10.3389/fimmu.2021.686956)
- Sha, S. et al. 2021. TLR9-deficiency in B cells promotes immune tolerance via IL-10 in a type 1 diabetes mouse model. Diabetes 70(2), pp. 504-515. (10.2337/db20-0373)
- Huang, J. et al. 2021. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular and Molecular Immunology 18, pp. 328-338. (10.1038/s41423-020-00590-8)
- Thayer, T. C., Davies, J., Pearson, J. A., Hanna, S. J., Wen, L. and Wong, F. S. 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70(2), pp. 529-537., article number: db191050. (10.2337/db19-1050)
2020
- Pearson, J. A., Wong, F. S. and Wen, L. 2020. Crosstalk between circadian rhythms and the microbiota. Immunology 161(4), pp. 278-290. (10.1111/imm.13278)
- Pearson, J. A. et al. 2020. Insulin-reactive T cells convert diabetogenic insulin-reactive VH125 B cells into tolerogenic cells by reducing germinal center T:B cell Interactions in NOD mice. Frontiers in Immunology 11, article number: 585886. (10.3389/fimmu.2020.585886)
- Huang, J. et al. 2020. Gut microbial metabolites alter IgA immunity in type 1 diabetes. JCI Insight 5(10), article number: e135718. (10.1172/jci.insight.135718)
2019
- Pearson, J. A. et al. 2019. Norovirus changes susceptibility to type 1 diabetes by altering intestinal microbiota and immune cell functions. Frontiers in Immunology 10, article number: 2654. (10.3389/fimmu.2019.02654)
- Pearson, J. A. et al. 2019. Altered gut microbiota activate and expand insulin B15-23-Reactive CD8+ T-Cells. Diabetes 68(5), pp. 1002-1013. (10.2337/db18-0487)
2018
- Liu, M. et al. 2018. Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes. Diabetologia 61(11), pp. 2333-2343. (10.1007/s00125-018-4705-0)
- Gülden, E. et al. 2018. TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells. Journal of Autoimmunity 93, pp. 57-65. (10.1016/j.jaut.2018.06.003)
- Majewska-Szczepanik, M. et al. 2018. Cyclophosphamide-modified murine peritoneal macrophages induce CD4+ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression. Pharmacological Reports 70(4), pp. 796-803. (10.1016/j.pharep.2018.02.015)
- Tan, Q. et al. 2018. Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice. JCI Insight 3(1), article number: 95882. (10.1172/jci.insight.95882)
2017
- Li, Y. Y. et al. 2017. Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota. Journal of Autoimmunity 82, pp. 85-95. (10.1016/j.jaut.2017.05.007)
2016
- Thayer, T. C. et al. 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65(11), pp. 3429-3439. (10.2337/db15-1649)
- Clement, M. et al. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6, article number: 35332. (10.1038/srep35332)
- Pearson, J. A. et al. 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65(6), pp. 1679-1689. (10.2337/db15-1498)
- Pearson, J. A., Wong, F. S. and Wen, L. 2016. The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes. Journal of Autoimmunity 66, pp. 76-88. (10.1016/j.jaut.2015.08.019)
2015
- Pearson, J. A. and Wong, F. S. 2015. Identification of islet antigen-specific CD8 T cells using MHCI-peptide tetramer reagents in the non obese diabetic (NOD) mouse model of type 1 diabetes. In: Gillespie, K. M. ed. Type-1 Diabetes., Vol. 1433. Methods in Molecular Biology Springer, pp. 119-125., (10.1007/7651_2015_295)
- Ye, J., Long, A. E., Pearson, J. A., Taylor, H., Bingley, P. J., Williams, A. J. K. and Gillespie, K. M. 2015. Attenuated humoral responses in HLA-A*24-positive individuals at risk of type 1 diabetes. Diabetologia 58(10), pp. 2284-2287. (10.1007/s00125-015-3702-9)
- Hu, C. et al. 2015. NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets. Proceedings of the National Academy of Sciences 112(36), pp. 11318-11323. (10.1073/pnas.1513509112)
- Motozono, C. et al. 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290(31), pp. 18924-18933. (10.1074/jbc.M114.622522)
2014
- Pearson, J. 2014. Analysis of the repertoire of insulin-reactive CD8+ T cells. PhD Thesis, Cardiff University.
Adrannau llyfrau
- Pearson, J. A. and Wong, F. S. 2015. Identification of islet antigen-specific CD8 T cells using MHCI-peptide tetramer reagents in the non obese diabetic (NOD) mouse model of type 1 diabetes. In: Gillespie, K. M. ed. Type-1 Diabetes., Vol. 1433. Methods in Molecular Biology Springer, pp. 119-125., (10.1007/7651_2015_295)
Erthyglau
- Haq, N. et al. 2024. Reformed islets: a long-term primary cell platform for exploring mouse and human islet biology. Cell Death Discovery 10, article number: 480. (10.1038/s41420-024-02234-6)
- Wang, P. et al. 2024. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 15(1), article number: 4232. (10.1038/s41467-024-48611-8)
- Pearson, J. A., Hu, Y., Peng, J., Wong, F. S. and Wen, L. 2024. TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model. Frontiers in Immunology 15, article number: 1333967. (10.3389/fimmu.2024.1333967)
- Pearson, J. A. et al. 2023. NLRP6 deficiency expands a novel CD103 + B cell population that confers immune tolerance in NOD mice. Frontiers in Immunology 14, article number: 1147925. (10.3389/fimmu.2023.1147925)
- Boldison, J. et al. 2022. Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes. Diabetologia 66(3), pp. 551-566. (10.1007/s00125-022-05839-7)
- Pearson, J. A. et al. 2022. IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans. Diabetologia 65(8), pp. 1398-1411. (10.1007/s00125-022-05711-8)
- Chan, K., Wong, F. S. and Pearson, J. A. 2022. Circadian rhythms and pancreas physiology: A review. Frontiers in Endocrinology 13, article number: 920261. (10.3389/fendo.2022.920261)
- Pearson, J. A., McKinney, E. F. and Walker, L. S. K. 2022. 100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes. Immunotherapy Advances (10.1093/immadv/ltab024)
- Huang, J., Pearson, J. A., Wong, F. S., Wen, L. and Zhou, Z. 2022. Innate immunity in latent autoimmune diabetes in adults (LADA). Diabetes/Metabolism Research and Reviews 38(1), article number: e3480. (10.1002/dmrr.3480)
- Pearson, J. A., Voisey, A. C., Boest Bjerg, K., Wong, F. S. and Wen, L. 2021. Circadian rhythm modulation of microbes during health and infection. Frontiers in Microbiology 12, article number: 721004. (10.3389/fmicb.2021.721004)
- Huang, J. et al. 2021. IL-10 deficiency accelerates type 1 diabetes development via modulation of innate and adaptive immune cells and gut microbiota in BDC2.5 NOD mice. Frontiers in Immunology 12, article number: 702955. (10.3389/fimmu.2021.702955)
- Pearson, J. A., Wong, F. S. and Wen, L. 2021. Inflammasomes and type 1 diabetes. Frontiers in Immunology 12, article number: 686956. (10.3389/fimmu.2021.686956)
- Sha, S. et al. 2021. TLR9-deficiency in B cells promotes immune tolerance via IL-10 in a type 1 diabetes mouse model. Diabetes 70(2), pp. 504-515. (10.2337/db20-0373)
- Huang, J. et al. 2021. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular and Molecular Immunology 18, pp. 328-338. (10.1038/s41423-020-00590-8)
- Thayer, T. C., Davies, J., Pearson, J. A., Hanna, S. J., Wen, L. and Wong, F. S. 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70(2), pp. 529-537., article number: db191050. (10.2337/db19-1050)
- Pearson, J. A., Wong, F. S. and Wen, L. 2020. Crosstalk between circadian rhythms and the microbiota. Immunology 161(4), pp. 278-290. (10.1111/imm.13278)
- Pearson, J. A. et al. 2020. Insulin-reactive T cells convert diabetogenic insulin-reactive VH125 B cells into tolerogenic cells by reducing germinal center T:B cell Interactions in NOD mice. Frontiers in Immunology 11, article number: 585886. (10.3389/fimmu.2020.585886)
- Huang, J. et al. 2020. Gut microbial metabolites alter IgA immunity in type 1 diabetes. JCI Insight 5(10), article number: e135718. (10.1172/jci.insight.135718)
- Pearson, J. A. et al. 2019. Norovirus changes susceptibility to type 1 diabetes by altering intestinal microbiota and immune cell functions. Frontiers in Immunology 10, article number: 2654. (10.3389/fimmu.2019.02654)
- Pearson, J. A. et al. 2019. Altered gut microbiota activate and expand insulin B15-23-Reactive CD8+ T-Cells. Diabetes 68(5), pp. 1002-1013. (10.2337/db18-0487)
- Liu, M. et al. 2018. Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes. Diabetologia 61(11), pp. 2333-2343. (10.1007/s00125-018-4705-0)
- Gülden, E. et al. 2018. TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells. Journal of Autoimmunity 93, pp. 57-65. (10.1016/j.jaut.2018.06.003)
- Majewska-Szczepanik, M. et al. 2018. Cyclophosphamide-modified murine peritoneal macrophages induce CD4+ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression. Pharmacological Reports 70(4), pp. 796-803. (10.1016/j.pharep.2018.02.015)
- Tan, Q. et al. 2018. Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice. JCI Insight 3(1), article number: 95882. (10.1172/jci.insight.95882)
- Li, Y. Y. et al. 2017. Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota. Journal of Autoimmunity 82, pp. 85-95. (10.1016/j.jaut.2017.05.007)
- Thayer, T. C. et al. 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65(11), pp. 3429-3439. (10.2337/db15-1649)
- Clement, M. et al. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6, article number: 35332. (10.1038/srep35332)
- Pearson, J. A. et al. 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65(6), pp. 1679-1689. (10.2337/db15-1498)
- Pearson, J. A., Wong, F. S. and Wen, L. 2016. The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes. Journal of Autoimmunity 66, pp. 76-88. (10.1016/j.jaut.2015.08.019)
- Ye, J., Long, A. E., Pearson, J. A., Taylor, H., Bingley, P. J., Williams, A. J. K. and Gillespie, K. M. 2015. Attenuated humoral responses in HLA-A*24-positive individuals at risk of type 1 diabetes. Diabetologia 58(10), pp. 2284-2287. (10.1007/s00125-015-3702-9)
- Hu, C. et al. 2015. NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets. Proceedings of the National Academy of Sciences 112(36), pp. 11318-11323. (10.1073/pnas.1513509112)
- Motozono, C. et al. 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290(31), pp. 18924-18933. (10.1074/jbc.M114.622522)
Gosodiad
- Pearson, J. 2014. Analysis of the repertoire of insulin-reactive CD8+ T cells. PhD Thesis, Cardiff University.
Ymchwil
Gellir rhannu fy ymchwil yn dri phrif faes ymchwil:
- Deall sut y gall mynegiant antigen, cyd-dderbynyddion a microbiota modiwleiddio swyddogaethau celloedd CD8 T adweithiol inswlin i nodi cyfleoedd posibl ar gyfer datblygu therapïau ataliol.
- Deall ymatebion cellog cynhenid, a rhyngweithio â'r microbiome, a sut mae hynny'n dylanwadu ar dueddiad i T1D.
- Deall rôl rhythmau circadaidd a sut maent yn dylanwadu ar ryngweithio rhwng y microbiome a'r celloedd imiwnedd cynhenid ac addasol wrth gyfryngu tueddiad i T1D.
Cyllid Lab Cyfredol:
Fel PI:
Gwobr Datblygu Gyrfa MRC (Chwefror 2020 – Hydref 2025): A all microbiota modiwleiddio osgiliadau circadaidd i newid tueddiad i awtoimiwnedd?
Grant SMF/JDRF UK (Ionawr 2024 - Ionawr 2026): Gwella llwyddiant imiwnotherapi Treg trwy weinyddu therapi ar wahanol adegau o'r dydd.
Fel y Co-I:
JDRF (Hydref 2024 - Medi 2027): Llwybr dethol L mewn diabetes math 1
JDRF (Ionawr 2025 - Rhagfyr 2027): Targedu'r boblogaeth imiwnedd preswylwyr islet i atal T1D
Hanes Cyllido:
Prosiect Ymchwil Pilor Prifysgol Gorllewin Michigan (Ebrill 2022 - Ionawr 2023): Rhythmicity Circadaidd Autoantibodies mewn diabetes Math 1
Grant Bach JDRF y DU (Awst 2021 - Gorffennaf 2022): A yw newidiadau sy'n ddibynnol ar amser mewn celloedd T rheoleiddiol yn newid eu gallu i atal datblygiad diabetes Math 1?
Cymrodoriaeth Ymchwil Ôl-ddoethurol Sefydliad Ymchwil Diabetes Ifanc (2016 – 2019)
Ysgoloriaeth Ymchwil Ôl-ddoethurol Fulbright-Diabetes UK (2015 – 2016)
Addysgu
Arweinydd a darlithydd ar MSc. Imiwnoleg Glinigol Gymhwysol ac Arbrofol
Bywgraffiad
Chwefror 2020 - Yn bresennol: Cymrawd Ymchwil MRC am Ddyfarniad Datblygu Gyrfa, Is-adran Heintiau ac Imiwnedd, Ysgol Meddygaeth, Prifysgol Caerdydd, Caerdydd, y DU
Anrhydeddau a dyfarniadau
- 2018 - Travel Award, Immunology of Diabetes Society
- 2018 - Travel Award, British Society for Immunology
- 2018 - Young Investigator Travel Award, BioLegend
- 2017 - Travel Award, Immunology of Diabetes Society
- 2014 - Travel Award, BioLegend
- 2014 - Travel Award, British Society for Immunology
- 2014 - Secretary for Vale of Glamorgan Volunteer Group, Diabetes Cymru UK
- 2013 - Raising Awareness Award, Diabetes UK Cymru
- 2013 - Travel Award, British Society for Immunology
- 2013 - 2nd Prize Oral Presentation Award, Postgraduate Research Day, School of Medicine, Cardiff University
- 2013 - Secretary for Vale of Glamorgan Volunteer Group, Diabetes Cymru UK
- 2012 - Secretary for Vale of Glamorgan Volunteer Group, Diabetes Cymru UK
- 2010 - Bristol Plus Award, University of Bristol
- 2009 - Summer Studentship, Society for General Microbiology
- 2008 - Faculty Commendation, University of Bristol
- 2007 - Faculty Commendation, University of Bristol
Aelodaethau proffesiynol
- 2020 - Present - Member, College of Experts, Cardiff University
- 2017 - Present - Member, Immunology of Diabetes Society
- 2016 - Present - Member, JDRF Microbiota Consortium
- 2015 - Present - Member, JDRF
- 2011 - Present - Member, British Society for Immunology
- 2011 - Present - Member, Diabetes UK
Safleoedd academaidd blaenorol
- 2020 - Present: Research Fellow, Cardiff University, UK
- 2016 - 2019: JDRF Postdoctoral Research Fellow, Endocrinology, Yale University, USA
- 2015 - 2016: Fulbright-Diabetes UK Postdoctoral Research Fellow, Endocrinology, Yale University, USA
Pwyllgorau ac adolygu
Journal reviewer, Nature Rev Endocrinology
Meysydd goruchwyliaeth
- Immunology
