Yr Athro Ole Petersen
CBE FRS

Timau a rolau for Ole Petersen

Cyfarwyddwr Prifysgol Caerdydd - Canolfan Wybodaeth Academia Europaea
Ysgol y Biowyddorau

Rwy'n Gyfarwyddwr Canolfan Wybodaeth Academia Europaea Prifysgol Caerdydd, yn goruchwylio gwaith y Brifysgol ar gyfer Mecanwaith Cyngor Gwyddonol y Comisiwn Ewropeaidd. Deuthum i Gaerdydd ar ddechrau 2010, gan olynu'r Llawryfog Nobel Syr Martin Evans FRS, fel Cyfarwyddwr Ysgol y Biowyddorau Caerdydd (2010-2015). Cyn hynny, cynhaliais Gadair Ffisioleg George Holt ym Mhrifysgol Lerpwl (1981-2009). Graddiais mewn Meddygaeth o Brifysgol Copenhagen ym 1969 ac yna roeddwn yn Gynorthwyydd ac yna'n Athro Cyswllt yn Copenhagen tan fy mhenodi'n Athro Symers mewn Ffisioleg ym Mhrifysgol Dundee (1975-1981). Mae fy ngwaith ymchwil wedi canolbwyntio ar ffisioleg a phathoffisioleg chwarennau exocrine. Arloesais arbrofion recordio presennol un sianel a chell gyfan ar gelloedd epithelaidd, gan ddarganfod sianeli ïon yn y celloedd hyn (a gyhoeddwyd mewn saith papur Natur yn yr 1980au). Darganfyddais wedyn y signalau calsiwm lleol mewn celloedd chwarren exocrine sy'n rheoli'r sianeli ïonau hyn (a gyhoeddwyd mewn pum papur Cell yn y 1990au). Mae fy ngwobrau rhyngwladol yn cynnwys Gwobr Jacobaeus Sefydliad NOVO Nordisk (Copenhagen, 1994), Medal Purkyne yr Academi Wyddoniaeth Tsiec (Prague, 2003), gwobr uchaf Cymdeithas Ffisiolegol America, Gwobr Goffa Walter B Cannon (San Diego, 2018), Medal Aur Academia Europaea (Barcelona, 2021) a gwobr uchaf Cymdeithas Ryngwladol Pancrealeg, Medal a Gwobr George E Palade (Kyoto, 2018). 2022). Rwyf wedi cael fy ethol yn Gymrawd / Aelod o nifer o academïau cenedlaethol gwyddoniaeth, gan gynnwys y Gymdeithas Frenhinol (2000), Academi Gwyddorau Cenedlaethol yr Almaen Leopoldina (2010), Academi Frenhinol Gwyddorau a Llythyrau Denmarc (1988) ac Academi Gwyddorau Hwngari (2004). Cyhoeddwyd fy mhenodiad fel CBE yn Rhestr Anrhydeddau'r Flwyddyn Newydd 2008 a derbyniais y wobr gan y Frenhines Elizabeth II yn bersonol ym Mhalas Buckingham ar 7 Mai 2008.

Darlith y Wobr yn Academi Genedlaethol Addysg Gwyddonwyr: XXIII. Cyfarfod y Enillwyr Nobel a Myfyrwyr Talentog, Szeged, Hwngari, 7 Rhagfyr 2024:

https://www.youtube.com/watch?v=vX3mYC-qZJ8

Ole H Petersen: Y Broses Wyddonol: Sut ydym ni'n ei gael yn iawn? Fideo o Ddarlith a gyflwynwyd yn y XXI. Cyfarfod y Enillwyr Nobel a Myfyrwyr Talentog, Szeged, Hwngari, 14 Rhagfyr 2023:

https://www.youtube.com/watch?v=Nzc5eM7ZKvg

Fy mhrif ddiddordeb ymchwil yw ym maes Signalau Calsiwm mewngellol, gyda phwyslais penodol ar gelloedd epithelaidd. Rwyf wedi olrhain tarddiad, a datblygiad dilynol, o'r maes ymchwil hwn sy'n ehangu'n gyflym yn fy nghofiant bywgraffyddol Syr Michael Berridge FRS, a gyhoeddwyd yn ddiweddar gan y Gymdeithas Frenhinol:

https://doi.org/10.1098/rsbm.2023.0047

Fy mynegai H presennol yw 107 (Google Scholar - https://scholar.google.com/citations?user=6z3BJ0oAAAAJ)

SWYDDOGAETHAU YMGYNGHOROL RHYNGWLADOL A CHENEDLAETHOL CYFREDOL:

*Aelod o Banel Peilot Pobl, Diwylliant a'r Amgylchedd REF2029 (Gwyddorau Biolegol), 2025

(Y Fframwaith Rhagoriaeth Ymchwil] yw system y DU ar gyfer asesu ansawdd ymchwil ym mhob sefydliad addysg uwch yn y DU)

*Aelod o Fwrdd Cynghori Rhyngwladol Canolfan Gwyddorau Naturiol Rhwydwaith Ymchwil Hwngari, Budapest, Hwngari, 2024-

*Athro Anrhydeddus Nodedig ym Mhrifysgol Al-Ahliyya Aman, Amman, Gwlad yr Iorddonen, 2025-

*Athro Anrhydeddus ym Mhrifysgol Jinan, Guangzhou, Tsieina, 2011-

CYMORTH GRANT PRESENNOL FEL PRIF YMCHWILYDD:

Y Comisiwn Ewropeaidd, Horizon Europe: 1 Ionawr 2025 - 30 Ebrill 2029

Date
Type

2024

Petersen, O. H. 2024. The Need for Inspiration and Admiration. Function 5(1), article number: zqae001. (10.1093/function/zqae001)

2018

Peng, S., Gerasimenko, J. V., Tsugorka, T. M., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2018. Galactose protects against cell damage in mouse models of acute pancreatitis. Journal of Clinical Investigation 128(9), pp. 3769-3778. (10.1172/JCI94714)
Gryshchenko, O., Gerasimenko, J., Peng, S., Gerasimenko, O. V. and Petersen, O. H. 2018. Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology. Journal of Physiology 596(14), pp. 2663-2678. (10.1113/JP275395)
Vervliet, T., Gerasimenko, J. V., Ferdek, P. E., Jakubowska, M. A., Petersen, O. H., Gerasimenko, O. V. and Bultynck, G. 2018. BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis. Cell Death Discovery 4, article number: 58. (10.1038/s41420-018-0054-5)

2017

Márta, K. et al. 2017. High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial. BMJ Open 7(9), pp. e015874. (10.1136/bmjopen-2017-015874)
Petersen, O. H., Courjaret, R. and Machaca, K. 2017. Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites. The Journal of Physiology 595(10), pp. 2999-3014. (10.1113/JP272772)
Petersen, O. 2017. The effects of Ca2+ buffers on cytosolic Ca2+ signalling. The Journal of Physiology 595(10), pp. 3107-3108. (10.1113/JP273852)
Ferdek, P. E., Jakubowska, M. A., Polina, N., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2017. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death and Disease 8, article number: e2640. (10.1038/cddis.2017.41)

2016

Ferdek, P. E., Jakubowska, M. A., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake. Journal of Physiology 594(21), pp. 6147-6164. (10.1113/JP272774)
Peng, S., Gerasimenko, J. V., Tsugorka, T., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2016. Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 371(1700), article number: 20150423. (10.1098/rstb.2015.0423)
Jakubowska, M. A., Ferdek, P. E., Gerasimenko, O. V., Gerasimenko, J. V. and Petersen, O. H. 2016. Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biology 6(8), article number: 160149. (10.1098/rsob.160149)
Mukherjee, R. et al. 2016. Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut 65(8), pp. 1333-1346. (10.1136/gutjnl-2014-308553)
Petersen, O. and Verkhratsky, A. 2016. Calcium and ATP control multiple vital functions. Philosophical Transactions of the Royal Society B: Biological Sciences 371(1700), pp. 20150418., article number: 20150418. (10.1098/rstb.2015.0418)
Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Calcium signalling in pancreatic stellate cells: mechanisms and potential roles. Cell Calcium 59(2-3), pp. 140-144. (10.1016/j.ceca.2016.02.003)
Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Ca2+ signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca2+ channel blockade. Journal of Physiology 594(2), pp. 281-293. (10.1113/JP271468)

2015

Huang, W. et al. 2015. Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca 2+ release. Gut 66(2), pp. 301-313. (10.1136/gutjnl-2015-309363)
Petersen, O. H. 2015. Ca2+ signalling in the endoplasmic reticulum/secretory granule microdomain. Cell Calcium 58(4), pp. 397-404. (10.1016/j.ceca.2015.01.006)
Gerasimenko, J. et al. 2015. Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release. Cell Calcium 58(3), pp. 237-245. (10.1016/j.ceca.2015.05.005)

2014

Petersen, O. H. 2014. Calcium signalling and secretory epithelia. Cell Calcium 55(6), pp. 282-289. (10.1016/j.ceca.2014.01.003)
Gerasimenko, J. V., Petersen, O. H. and Gerasimenko, O. V. 2014. Monitoring of intra-ER free Ca2+. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 3(3), pp. 63-71. (10.1002/wmts.106)
Petersen, O. H. 2014. Can specific calcium channel blockade be the basis for a drug-based treatment of acute pancreatitis?. Expert Review of Gastroenterology & Hepatology 8(4), pp. 339-341. (10.1586/17474124.2014.896192)
Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2014. The role of Ca2+ in the pathophysiology of pancreatitis. The Journal of Physiology 592(2), pp. 269-280. (10.1113/jphysiol.2013.261784)
Huang, W. et al. 2014. Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis. Gut 63(8), pp. 1313-1324. (10.1136/gutjnl-2012-304058)

2013

Gerasimenko, J. V. et al. 2013. Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proceedings of the National Academy of Sciences of the United States of America 110(32), pp. 13186-13191. (10.1073/pnas.1300910110)
Heygi, P. and Petersen, O. 2013. The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. In: Nilius, B. et al. eds. Reviews of Physiology, Biochemistry and Pharmacology., Vol. 165. Cham, Switzerland: Springer Verlag, pp. 1-30., (10.1007/112_2013_14)

2012

Ferdek, P., Gerasimenko, J. V., Peng, S., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2012. A novel role for Bcl-2 in regulation of cellular calcium extrusion. Current Biology 22(13), pp. 1241-1246. (10.1016/j.cub.2012.05.002)
Gerasimenko, O. V., Petersen, O. H. and Gerasimenko, J. V. 2012. Role of intracellular acid Ca2+ stores in pathological pancreatic protease activation [Editorial]. Expert Review of Gastroenterology & Hepatology 6(2), pp. 129-131. (10.1586/EGH.12.5)
Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2012. The war within - unraveling the molecular causes of acute pancreatitis - a potentially deadly disease in which the pancreas essentially digests itself - is yielding clues to how it might be treated. The Scientist 26(2), pp. 40-44.
Spät, A. and Petersen, O. H. 2012. A special issue on the cell-specific roles of mitochondrial Ca2+ handling [Editorial]. Pflugers Archiv European Journal of Physiology 464(1), pp. 1-2. (10.1007/s00424-012-1123-x)
Petersen, O. H. 2012. Specific mitochondrial functions in separate sub-cellular domains of pancreatic acinar cells. Pflugers Archiv European Journal of Physiology 464(1), pp. 77-87. (10.1007/s00424-012-1099-6)

2011

Petersen, O. H., Gerasimenko, O. V., Tepikin, A. and Gerasimenko, J. V. 2011. Aberrant Ca2+ signalling through acidic calcium stores in pancreatic acinar cells. Cell Calcium 50(2), pp. 193-199. (10.1016/j.ceca.2011.02.010)
Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2011. Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000 Medicine Reports(3), article number: 15. (10.3410/M3-15)
Booth, D. et al. 2011. Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140(7), pp. 2116-2125. (10.1053/j.gastro.2011.02.054)
Gerasimenko, J. V. et al. 2011. Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 108(14), pp. 5873-5878. (10.1073/pnas.1016534108)
Lur, G. et al. 2011. InsP3 receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. Biochemical Journal 436(2), pp. 231-239. (10.1042/BJ20110083)

2010

Verkhratsky, A. and Petersen, O. H. 2010. Bernd Nilius: The Bard of ion channels. Congratulations on 65th birthday. Pflügers Archiv European Journal of Physiology 460(4), pp. 691-694. (10.1007/s00424-010-0857-6)
Voronina, S. G. et al. 2010. Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138(5), pp. 1976-1987. (10.1053/j.gastro.2010.01.037)
Petersen, O. H. 2010. Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology. Brazilian Journal of Medical and Biological Research 42(1), pp. 9-16.
Chvanov, M., Petersen, O. H. and Tepikin, A. V. 2010. Pharmacologically directed cell disposal: labelling damaged cells for phagocytosis as a strategy against acute pancreatitis. Molecular Interventions 10(2), pp. 80-85. (10.1124/mi.10.2.9)
Walsh, C. M., Chvanov, M., Haynes, L. P., Petersen, O. H., Tepikin, A. V. and Burgoyne, R. D. 2010. Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochemical Journal 425(1), pp. 159-168. (10.1042/BJ20090884)
Verkhratsky, A. and Petersen, O. H. 2010. Principles of the Ca2+ homeostatic/signalling system. In: Verkhratsky, A. and Petersen, O. H. eds. Calcium Measurement Methods. Neuromethods Vol. 43. New York: Humana Press, pp. 1-11., (10.1007/978-1-60761-476-0_1)
Blum, R., Petersen, O. H. and Verkhratsky, A. 2010. Ca2+ imaging of intracellular organelles: endoplasmic reticulum. In: Verkhratsky, A. and Petersen, O. H. eds. Calcium measurement methods. Neuromethods Vol. 43. New York: Humana Press, pp. 146-167., (10.1007/978-1-60761-476-0_8)
Verkhratsky, A. N. and Petersen, O. H. 2010. Preface. In: Verkhratsky, A. N. and Petersen, O. H. eds. Calcium Measurement Methods. Neuromethods Vol. 43. New York, NY; London: Humana Press, pp. vii-vii.

2009

Petersen, O. H. 2009. The International Union of Physiological Sciences IUPS Editorial VIII [Editorial]. Physiology 24(6), pp. 320-321. (10.1152/physiol.00035.2009)
Lur, G. et al. 2009. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology 19(19), pp. 1648-1653. (10.1016/j.cub.2009.07.072)
Baumgartner, H. K. et al. 2009. Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. Journal of Biological Chemistry 284(31), pp. 20796-20803. (10.1074/jbc.M109.025353)
Petersen, O. H., Tepikin, A. V., Gerasimenko, J. V., Gerasimenko, O. V., Sutton, R. and Criddle, D. N. 2009. Fatty acids, alcohol and fatty acid ethyl esters: Toxic Ca2+ signal generation and pancreatitis. Cell Calcium 45(6), pp. 634-642. (10.1016/j.ceca.2009.02.005)
Gerasimenko, J. V. et al. 2009. Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 106(26), pp. 10758-10763. (10.1073/pnas.0904818106)
Criddle, D. N. et al. 2009. Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 297(6), pp. G1085-G1092. (10.1152/ajpgi.00119.2009)
Walsh, C., Barrow, S., Voronina, S., Chvanov, M., Petersen, O. H. and Tepikin, A. V. 2009. Modulation of calcium signalling by mitochondria. Biochimica et Biophysica Acta-Bioenergetics 1787(11), pp. 1374-1382. (10.1016/j.bbabio.2009.01.007)

2008

Kaneko, A. and Petersen, O. H. 2008. The International Union of Physiological Sciences IUPS Editorial VI [Editorial]. Physiology 23(6), pp. 308-309. (10.1152/physiol.00027.2008)
Mukherjee, R., Criddle, D. N., Gukovskaya, A., Pandol, S., Petersen, O. H. and Sutton, R. 2008. Corrigendum to “Mitochondrial injury in pancreatitis” [Cell Calcium 44 (1) (2008) 14–23]. Cell Calcium 44(5), pp. 520. (10.1016/j.ceca.2008.07.001)
Kaneko, A. and Petersen, O. H. 2008. The International Union of Physiological Sciences IUPS Editorial V [Editorial]. Physiology 23(3), pp. 126-127. (10.1152/physiol.00012.2008)
Sutton, R. D., Petersen, O. H. and Pandol, S. J. 2008. Pancreatitis and Calcium Signalling: Report of an International Workshop. Pancreas 36(4), pp. e1-e14. (10.1097/MPA.0b013e3181675010)
Barrow, S. L. et al. 2008. ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Archiv - European Journal of Physiology 455(6), pp. 1025-1039. (10.1007/s00424-007-0360-x)
Chvanov, M. et al. 2008. ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflugers Archiv-European Journal of Physiology 457(2), pp. 505-517. (10.1007/s00424-008-0529-y)
Petersen, O. H. 2008. Ca2+-induced pancreatic cell death: Roles of the endoplasmic reticulum, zymogen granules, lysosomes and endosomes. Journal of Gastroenterology and Hepatology 23(S1), pp. S31-S36. (10.1111/j.1440-1746.2007.05281.x)
Murphy, J. A. et al. 2008. Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135(2), pp. 632-641. (10.1053/j.gastro.2008.05.026)
Park, M. K., Choi, Y. M., Kang, Y. K. and Petersen, O. H. 2008. The endoplasmic reticulum as an integrator of multiple dendritic events. Neuroscientist 14(1), pp. 68-77. (10.1177/1073858407305691)
Mukheriee, R., Criddle, D. N., Gukvoskaya, A., Pandol, S., Petersen, O. H. and Sutton, R. 2008. Mitochondrial injury in pancreatitis. Cell Calcium 44(1), pp. 14-23. (10.1016/j.ceca.2007.11.013)
Petersen, O. H. and Tepikin, A. V. 2008. Polarized calcium signaling in exocrine gland cells. Annual Review of Physiology 70, pp. 273-299. (10.1146/annurev.physiol.70.113006.100618)

2007

Kaneko, A. and Petersen, O. H. 2007. The International Union of Physiological Sciences IUPS Editorial IV [Editorial]. Physiology 22(6), pp. 354. (10.1152/physiol.00038.2007)
Criddle, D. N., McLaughlin, E., Murphy, J. A., Petersen, O. H. and Sutton, R. 2007. The pancreas misled: signals to pancreatitis. Pancreatology 7(5-6), pp. 436-446. (10.1159/000108960)
Baumgartner, H. K. et al. 2007. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(1), pp. G296-G307. (10.1152/ajpgi.00103.2007)
Kaneko, A. and Petersen, O. H. 2007. The International Union of Physiological Sciences IUPS Editorial III [Editorial]. Physiology 22(3), pp. 156-157. (10.1152/physiol.00013.2007)
Voronina, S. G., Sherwood, M. W., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2007. Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran-bound indicator: endocytic and nonendocytic vacuoles. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(6), pp. G1333-G1338. (10.1152/ajpgi.00275.2007)
Petersen, O. H. and Verkhratsky, A. 2007. Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells. Cell Calcium 42(4-5), pp. 373-378. (10.1016/j.ceca.2007.05.012)
Criddle, D. N. et al. 2007. Calcium signalling and pancreatic cell death: apoptosis or necrosis?. Cell Death and Differentiation 14(7), pp. 1285-1294. (10.1038/sj.cdd.4402150)
Nicotera, P., Petersen, O. H., Melino, G. and Verkhratsky, A. 2007. Janus a god with two faces: death and survival utilise same mechanisms conserved by evolution. Cell Death and Differentiation 14(7), pp. 1235-1236. (10.1038/sj.cdd.4402161)
Sherwood, M. W. et al. 2007. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 104(13), pp. 5674-5679. (10.1073/pnas.0700951104)

2006

Criddle, D. N. et al. 2006. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. Journal of Biological Chemistry 281(52), pp. 40485-40492. (10.1074/jbc.M607704200)
Criddle, D. N., Sutton, R. and Petersen, O. H. 2006. Role of Ca2+ in pancreatic cell death induced by alcohol metabolites. Journal of Gastroenterology and Hepatology 21(Sup.s3), pp. S14-S17. (10.1111/j.1440-1746.2006.04577.x)
Petersen, O. H. 2006. The FEPS Inaugural Lecture – Bristol 2005 [Editorial]. Acta Physiologica 187(3), pp. 353. (10.1111/j.1748-1716.2006.01572.x)
Criddle, D. N. et al. 2006. Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis. Gastroenterology 130(3), pp. 781-793. (10.1053/j.gastro.2005.12.031)
Petersen, O. H. and Sutton, R. 2006. Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee. Trends in Pharmacological Sciences 27(2), pp. 113-120. (10.1016/j.tips.2005.12.006)
Kaneko, A. and Petersen, O. H. 2006. The International Union of Physiological Sciences: IUPS Editorial [Editorial]. Physiology 21(1), pp. 2. (10.1152/physiol.00061.2005)
Gerasimenko, J. V., Flowerdew, S. E., Voronina, S. G., Sukhomlin, T. K., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2006. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. Journal of Biological Chemistry 281(52), pp. 40154-40163. (10.1074/jbc.M606402200)
Verkhratsky, A., Krishtal, O. A. and Petersen, O. H. 2006. From Galvani to patch clamp: the development of electrophysiology. Pflugers Archiv European Journal of Physiology 453(3), pp. 233-247. (10.1007/s00424-006-0169-z)
Petersen, O. H., Sutton, R. and Criddle, D. N. 2006. Failure of calcium microdomain generation and pathological consequences. Cell Calcium 40(5-6), pp. 593-600. (10.1016/j.ceca.2006.08.020)
Menteyne, A., Burdakov, A., Charpentier, G., Petersen, O. H. and Cancela, J. 2006. Generation of Specific Ca2+ Signals from Ca2+ Stores and Endocytosis by Differential Coupling to Messengers. Current Biology 16(19), pp. 1931-1937. (10.1016/j.cub.2006.07.070)
Chvanov, M., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2006. Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO Journal 25(13), pp. 3024. (10.1038/sj.emboj.7601207)
Gerasimenko, J. V., Sherwood, M., Tepikin, A., Petersen, O. H. and Gerasimenko, O. V. 2006. NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. Journal of Cell Science 119(2), pp. 226-238. (10.1242/jcs.02721)

2005

Chvanov, M., Petersen, O. H. and Tepikin, A. 2005. Free radicals and the pancreatic acinar cells: role in physiology and pathology. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360(1464), pp. 2273-2284. (10.1098/rstb.2005.1757)
Petersen, O. H., Spat, A. and Verkhratsky, A. 2005. Introduction: reactive oxygen species in health and disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360(1464), pp. 2197-2199. (10.1098/rstb.2005.1776)
Dolman, N. J., Gerasimenko, J. V., Gerasimenko, O. V., Voronina, S. G., Petersen, O. H. and Tepikin, A. V. 2005. Stable Golgi-mitochondria complexes and formation of Golgi Ca2+ gradients in pancreatic acinar cells. Journal of Biological Chemistry 280(16), pp. 15794-15799. (10.1074/jbc.M412694200)
Knot, H. J. et al. 2005. Twenty years of calcium imaging: cell physiology to dye for. Molecular Interventions 5(2), pp. 112-127. (10.1124/mi.5.2.8)
Voronina, S. G., Gryshchenko, O. V., Gerasimenko, O. V., Green, A. K., Petersen, O. H. and Tepikini, A. V. 2005. Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration. Journal of Biological Chemistry 280(3), pp. 1764-1770. (10.1074/jbc.M410230200)
Petersen, O. H., Michalak, M. and Verkhratsky, A. 2005. Calcium signalling: past, present and future. Cell Calcium 38(3-4), pp. 161-169. (10.1016/j.ceca.2005.06.023)
Burdakov, D., Petersen, O. H. and Verkhratsky, A. 2005. Intraluminal calcium as a primary regulator of endoplasmic reticulum function. Cell Calcium 38(3-4), pp. 303-310. (10.1016/j.ceca.2005.06.010)
Petersen, O. H. 2005. Ca2+ signalling and Ca2+-activated ion channels in exocrine acinar cells. Cell Calcium 38(3-4), pp. 171-200. (10.1016/j.ceca.2005.06.024)
Galione, A. and Petersen, O. H. 2005. The NAADP receptor: new receptors or new regulation?. Molecular Interventions 5(2), pp. 73-79. (10.1124/mi.5.2.4)

2004

Criddle, D. N., Raraty, M. G. T., Neoptolemos, J. P., Tepikin, A. V., Petersen, O. H. and Sutton, R. 2004. Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites. Proceedings of the National Academy of Sciences of the United States of America 101(29), pp. 10738-10743. (10.1073/pnas.0403431101)
Voronina, S. G., Barrow, S. L., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2004. Effects of secretagogues and gile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating ΔΨm. Journal of Biological Chemistry 279(26), pp. 27327-27338. (10.1074/jbc.M311698200)
Park, M. K., Lee, M. and Petersen, O. H. 2004. Morphological and functional changes of dissociated single pancreatic acinar cells: testing the suitability of the single cell as a model for exocytosis and calcium signaling. Cell Calcium 35(4), pp. 367-379. (10.1016/j.ceca.2003.10.003)
Yano, K., Petersen, O. H. and Tepikin, A. V. 2004. Dual sensitivity of sarcoplasmic/endoplasmic Ca2+-ATPase to cytosolic and endoplasmic reticulum Ca2+ as a mechanism of modulating cytosolic Ca2+ oscillations. Biochemical Journal 383(2), pp. 353-360. (10.1042/BJ20040629)
Petersen, O. H. 2004. Local and global Ca2+ signals: physiology and pathophysiology. Biological Research 37(4), pp. 661-664.

2003

Gerasimenko, J. V., Maruyama, Y., Yano, K., Dolman, N. J., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2003. NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. Journal of Cell Biology 163(2), pp. 271-282. (10.1083/jcb.200306134)
Dolman, N. J., Tepikin, A. and Petersen, O. H. 2003. Generation and modulation of cytosolic Ca2+ signals in pancreatic acinar cells: Techniques and mechanisms. Biochemical Society Transactions 31(5), pp. 947-949.
Johnson, P. R., Dolman, N. J., Pope, M., Vaillant, C., Petersen, O. H., Tepikin, A. V. and Erdemli, G. 2003. Non-uniform distribution of mitochondria in pancreatic acinar cells. Cell and Tissue Research 313(1), pp. 37-45. (10.1007/s00441-003-0741-1)
Ashby, M. C., Camello-Almaraz, C., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2003. Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. Journal of Biological Chemistry 278(23), pp. 20860-20864. (10.1074/jbc.M302599200)
Mogami, H., Zhang, H., Suzuki, Y., Urano, T., Saito, N., Kojima, I. and Petersen, O. H. 2003. Decoding of short-lived Ca2+ influx signals into long term substrate phosphorylation through activation of two distinct classes of protein kinase C. Journal of Biological Chemistry 278(11), pp. 9896-9904. (10.1074/jbc.M210653200)
Gerasimenko, O. V., Maruyama, Y., Tepikin, A., Petersen, O. H. and Gerasimenko, J. V. 2003. Calcium signalling in and around the nuclear envelope. Biochemical Society Transactions 31(1), pp. 76-78.
Sutton, R., Criddle, D., Raraty, M. G. T., Tepikin, A., Neoptolemos, J. P. and Petersen, O. H. 2003. Signal transduction, calcium and acute pancreatitis. Pancreatology 3(6), pp. 497-505. (10.1159/000075581)
Petersen, O. H. 2003. Localization and regulation of Ca2+ entry and exit pathways in exocrine gland cells. Cell Calcium 33(5-6), pp. 337-344. (10.1016/S0143-4160(03)00047-2)
Ashby, M. C., Petersen, O. H. and Tepikin, A. V. 2003. Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells. Biochemical Journal 369(3), pp. 441-445. (10.1042/BJ20021039)
Cancela, J. M., Charpentier, G. and Petersen, O. H. 2003. Co-ordination of Ca2+ signalling in mammalian cells by the new Ca2+-releasing messenger NAADP. Pflugers Archiv: European Journal of Physiology 446(3), pp. 322-327. (10.1007/s00424-003-1035-x)
Petersen, O. H. 2003. FEPS in Nice: a date with the best of European Physiology. Pflugers Archiv European Journal of Physiology 446(2), pp. 285-286. (10.1007/s00424-003-1047-6)

2002

Cancela, J. M. and Petersen, O. H. 2002. Regulation of intracellular Ca2+ stores by multiple Ca2+-releasing messengerS. Diabetes 51(Supp 3), pp. S349-S357. (10.2337/diabetes.51.2007.S349)
Petersen, O. H. 2002. Cation channels: homing in on the elusive CAN channels. Current Biology 12(15), pp. R520-R522. (10.1016/S0960-9822(02)01027-8)
Lomax, R. B., Camello, C., Van Coppenolle, F., Petersen, O. H. and Tepikin, A. V. 2002. Basal and physiological Ca2+ leak from the endoplasmic reticulum of pancreatic acinar cells: second messenger-activated channels and translocons. Journal of Biological Chemistry 277(29), pp. 26479-26485. (10.1074/jbc.M201845200)
Verkhratsky, A. and Petersen, O. H. 2002. The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death. European Journal of Pharmacology 447(2-3), pp. 141-154. (10.1016/S0014-2999(02)01838-1)
Yu, L. et al. 2002. An N-terminal truncated form of Orp150 Is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import. Journal of Biological Chemistry 277(27), pp. 24538-24545. (10.1074/jbc.M203550200)
Park, M., Tepikin, A. V. and Petersen, O. H. 2002. What can we learn about cell signalling by combining optical imaging and patch clamp techniques?. Pflugers Archiv: European Journal of Physiology 444(3), pp. 305-316. (10.1007/s00424-002-0832-y)
Voronina, S., Longbottom, R., Sutton, R., Petersen, O. H. and Tepikin, A. 2002. Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. The Journal of Physiology 540(1), pp. 49-55. (10.1113/jphysiol.2002.017525)
Cancela, J. M., Van Coppenolle, F., Galione, A., Tepikin, A. V. and Petersen, O. H. 2002. Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers. EMBO Journal 21(5), pp. 909-919. (10.1093/emboj/21.5.909)
Gerasimenko, J. V., Gerasimenko, O. V., Palejwala, A., Tepikin, A., Petersen, O. H. and Watson, A. J. M. 2002. Menadione-induced apoptosis: Roles of cytosolic Ca2+ elevations and the mitochondrial permeability transition pore. Journal of Cell Science 115, pp. 485-497.
Voronina, S., Sukhomlin, T., Johnson, P. R., Erdemli, G., Petersen, O. H. and Tepikin, A. 2002. Correlation of NADH and Ca2+ signals in mouse pancreatic acinar cells. The Journal of Physiology 539(1), pp. 41-52. (10.1113/jphysiol.2001.013134)
Gerasimenko, O. V., Gerasimenko, J. V., Rizzuto, R. R., Treiman, M., Tepikin, A. V. and Petersen, O. H. 2002. The distribution of the endoplasmic reticulum in living pancreatic acinar cells. Cell Calcium 32(5-6), pp. 261-268. (10.1016/S0143416002001938)
Bootman, M. D., Petersen, O. H. and Verkhratsky, A. 2002. The endoplasmic reticulum is a focal point for co-ordination of cellular activity. Cell Calcium 32(5-6), pp. 231-234. (10.1016/S0143416002002002)
Camello, C., Lomax, R., Petersen, O. H. and Tepikin, A. V. 2002. Calcium leak from intracellular stores - the enigma of calcium signalling. Cell Calcium 32(5-6), pp. 355-361. (10.1016/S0143416002001926)
Ashby, M. C., Craske, M., Park, M. K., Gerasimenko, O. V., Burgoyne, R. D., Petersen, O. H. and Tepikin, A. V. 2002. Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves. Journal of cell biology 158(2), pp. 283-292.
Petersen, O. H. and Burdakova, N. 2002. The specificity of Ca 2+ signalling.. Acta Physiologica Hungarica 89(4), pp. 439-450. (10.1556/APhysiol.89.2002.4.4)

2001

Petersen, O. H. 2001. Letter from The President. Pflugers Archiv: European Journal of Physiology 443(2), pp. 331-332. (10.1007/s004240100692)
Park, M. K., Lomax, R. B., Tepikin, A. V. and Petersen, O. H. 2001. Local uncaging of caged Ca2+ reveals distribution of Ca2+-activated Cl- channels in pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 98(19), pp. 10948-10953. (10.1073/pnas.181353798)
Petersen, O. H. and Fedirko, N. V. 2001. Calcium signalling: store-operated channel found at last. Current Biology 11(13), pp. R520-R523. (10.1016/S0960-9822(01)00309-8)
Petersen, O. H., Tepikin, A. and Park, M. K. 2001. The endoplasmic reticulum: one continuous or several separate Ca2+ stores?. Trends in Neurosciences 24(5), pp. 271-276. (10.1016/S0166-2236(00)01787-2)
Burdakov, D., Cancela, J. M. and Petersen, O. H. 2001. Bombesin-induced cytosolic Ca2+spiking in pancreatic acinar cells depends on cyclic ADP-ribose and ryanodine receptors. Cell Calcium 29(3), pp. 211-216. (10.1054/ceca.2000.0188)
Petersen, O. H. 2001. Physiologists, physiology departments and universities: discipline and interdisciplinarity. Pflugers Archiv: European Journal of Physiology 441(5), pp. 725-727. (10.1007/s004240000477)
Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2001. Membrane repair: Ca2+-elicited lysosomal exocytosis. Current Biology 11(23), pp. R971-R974. (10.1016/S0960-9822(01)00577-2)
Park, M. K., Ashby, M. C., Erdemli, G., Petersen, O. H. and Tepikin, A. V. 2001. Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport. EMBO Journal 20(8), pp. 1863-1874. (10.1093/emboj/20.8.1863)

2000

Raraty, M., Ward, J., Erdemli, G., Vaillant, C., Neoptolemos, J. P., Sutton, R. and Petersen, O. H. 2000. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 97(24), pp. 13126-13131. (10.1073/pnas.97.24.13126)
Cansela, J. M., Gerasimenko, O. V., Gerasimenko, J. V., Tepikin, A. V. and Petersen, O. H. 2000. Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate. Embo Journal 19(11), pp. 2549-2557. (10.1093/emboj/19.11.2549)
Petersen, O. H. and Cancela, J. M. 2000. Nerve guidance: Attraction or repulsion by local Ca2+ signals. Current Biology 10(8), pp. R311-R314. (10.1016/S0960-9822(00)00438-3)
Park, M. K., Petersen, O. H. and Tepikin, A. V. 2000. The endoplasmic reticulum as one continuous Ca2+ pool: Visualization of rapid Ca2+ movements and equilibration. Embo Journal 19(21), pp. 5587-5941. (10.1093/emboj/19.21.5729)
Petersen, O. H. 2000. The functional organisation of calcium signalling in exocrine acinar cells. Journal of Korean Medical Science 15, pp. S44-S45. (10.3346/jkms.2000.15.S.S44)

Prif Gyflawniadau Ymchwil

Arloesais, gyda Yoshio Maruyama, sianel sengl clamp patch a recordiadau cyfredol celloedd cyfan mewn celloedd epithelaidd, gan ddarparu tystiolaeth bendant ar gyfer presenoldeb a phwysigrwydd sianeli ïon rheoledig wrth reoli swyddogaeth epithelaidd. Fe wnaethon ni ddarganfod actifadu sianel ïonau sy'n cael ei galw gan hormonau, wedi'i gyfryngu gan negesydd (Maruyama a Petersen Nature 1982a, b), actifadu foltedd sianeli ïonau epithelial (Maruyama et al Nature 1983a, b) ac integreiddio'r data hyn i'r model cyntaf o sut mae sianeli ïon yn rheoli secretion hylif exocrine (Petersen & Maruyama Nature 1984 [ISI [WoS] Citation Classic]; Petersen J Physiol 1992). Darganfyddais sbeicio Ca2+ is-gellog mewn celloedd epithelaidd (Wakui et al Nature 1989, Cell 1990; Thorn et al Cell 1993), rhyddhau Ca2+ a gyfryngwyd gan negesydd o'r amlen niwclear (Gerasimenko et al Cell 1995) yn ogystal â'r gronynnau ysgrifenyddol (Gerasimenko et al Cell 1996) a twneli Ca2 + mewngellog (Mogami et al Cell 1997). Ynghyd ag Oleg a Julia Gerasimenko, gwnaethom ddangos rôl hanfodol sianeli rhyddhau Ca2 + a mynediad Ca2+ a weithredir gan storfeydd mewn Pancreatitis Acíwt (Raraty et al PNAS 2000; Gerasimenko et al PNAS 2009; 2011), darparu prawf o egwyddor ar gyfer blocâd sianel Ca2 + (CRAC) rhyddhau Ca2 + (CRAC) fel triniaeth o Pancreatitis Acíwt difrifol (Gerasimenko et al PNAS 2013; J Physiol 2014) a darganfod rôl hanfodol ar gyfer celloedd stella pancreatig yn y clefyd hwn (Ferdek et al J Physiol 2016; Gryshchenko et al J Physiol 2016,2018). Yn fwy diweddar, rydym wedi darganfod digwyddiadau signalau Ca2 + mewn celloedd imiwnedd pancreatig sy'n debygol o fod yn bwysig ar gyfer cychwyn y storm cytokine sy'n gyfrifol am achosion difrifol, ac angheuol yn aml, o Pancreatitis Acíwt (Gryshchenko et al Function 2021). Yn fwy diweddar, rydym wedi darganfod bod y protein spike SARS-CoV-2 yn ennyn signalau Ca2 + mewn celloedd stella pancreatig yn y fan a'r lle a bod y signalau hyn yn eu tro yn ysgogi signalau Ca2 + mewn macroffagau pancreatig (Gerasimenko et al Function 2022). Mae'r effeithiau hyn yn cysylltu digwyddiadau mewn Pancreatitis Acíwt difrifol â'r hyn sy'n digwydd yn Covid-19 ac maent bellach yn cael eu harchwilio ymhellach.

Gwaith ymchwil cyfredol

Rydym yn parhau â'n gwaith i ddiffinio'r union fecanweithiau mewn-gellog a rhyng-gellog sy'n gyrru'r clefyd dynol pwysig Pancreatitis Acíwt ac i nodi'r pwyntiau ymyrraeth ffarmacolegol gorau posibl a allai atal a / neu wella'r clefyd hwn. Rydym yn dilyn papur pwysig yn J Clin Invest (Peng et al 2018) lle gwnaethom ddangos y gall galactose (cynhwysyn mawr mewn llaeth dynol arferol) amddiffyn yn effeithiol iawn yn erbyn Pancreatitis Acíwt.

Rôl yn y Mecanwaith Cynghori ar Wyddoniaeth Ewropeaidd

Yn ogystal â'm gwaith ymchwil sylfaenol, rwyf hefyd yn ymwneud yn helaeth â Mecanwaith Cyngor Gwyddonol yr Undeb Ewropeaidd. Fel Cyfarwyddwr Canolfan Wybodaeth Prifysgol Caerdydd Academia Europaea, rwyf yn gyfrifol am waith yr Academi ar gyfer SAPEA (Science Advice for Policy gan European Academies), sy'n rhan hanfodol o SAM y Comisiwn Ewropeaidd (Scientific Advice Mechanism). Y diben yw darparu a chyhoeddi Adroddiadau Adolygu Tystiolaeth i lywio ac ategu Barn Wyddonol Grŵp Prif Gynghorwyr Gwyddoniaeth y Comisiwn Ewropeaidd mewn ymateb i gwestiynau gan y Comisiynwyr. Mae Academia Europaea yn un o'r 5 rhwydwaith Ewropeaidd sy'n cynnwys SAPEA ac mae gwaith Academia Europaea yn hyn o beth yn cael ei wneud gan Ganolfan Wybodaeth Academia Europaea Prifysgol Caerdydd. Gellir gweld ein holl Adroddiadau Adolygu Tystiolaeth trwy wefan SAPEA (www.sapea.info) ac maent yn Mynediad Agored.

Cydweithredwyr yn Ysgol y Biowyddorau

* Dr Oleg Gerasimenko (Darllenydd)

* Dr Julia Gerasimenko (Uwch Ddarlithydd)

Staff cysylltiedig

Ymchwil Sylfaenol

Dr Oleksiy Gryschenko (Uwch Wyddonydd Ymweld Rheolaidd o Sefydliad Ffisioleg Bogomoletz, Academi Genedlaethol y Gwyddorau Wcráin)
Dr Shuang Peng (Athro Cyswllt Ymweld Rheolaidd o Brifysgol Jinan, Guangzhou, Tsieina

Academia Europaea a Mecanwaith Cyngor Gwyddoniaeth Ewropeaidd

* Ms Louise Edwards (Rheolwr Hwb, Academia Europaea - Canolfan Wybodaeth Prifysgol Caerdydd)

* Mrs Juliet Davies (Swyddog Gweithredol, Academia Europaea - Canolfan Wybodaeth Prifysgol Caerdydd)

* Ms Alice Sadler (Swyddog Cyfathrebu, Academia Europaea - Canolfan Wybodaeth Prifysgol Caerdydd)

Addysg/Graddau

Myfyriwr meddygol, Prifysgol Copenhagen 1961 - 1969

Cand. Med. (Laudabilis) (MB ChB) Prifysgol Copenhagen, 1969

Ymarferydd Meddygol Awdurdodedig (Awdurdod Iechyd Gwladwriaeth Denmarc) 1969

Dr. med. (MD) Prifysgol Copenhagen, 1972, ar gyfer traethawd ymchwil "Cludiant ïonau a achosir gan acetylcholine sy'n ymwneud â ffurfio poer" (Traethawd ymchwil a gyhoeddwyd fel Atodiad 381 yn Acta physiol scand [ Acta Physiologica bellach] 1972)

Swyddi a ddelir

Darlithydd, Sefydliad Ffisioleg Feddygol, Prifysgol Copenhagen, 1969-73

Cymrawd Ymchwil Teithio Wellcome-Carlsberg, Adran Ffarmacoleg, Prifysgol Caergrawnt, DU, 1971-72 (ar absenoldeb o Brifysgol Copenhagen)

Uwch Ddarlithydd, Sefydliad Ffisioleg Feddygol, Prifysgol Copenhagen, Denmarc, 1973-78

Athro Symers mewn Ffisioleg a Phennaeth yr Adran Ffisioleg, Prifysgol Dundee, yr Alban, 1975-81 (ar absenoldeb o Brifysgol Copenhagen 1975-78).

Pennaeth yr Adran Ffisioleg, Prifysgol Lerpwl, 1981-1998

George Holt Athro Ffisioleg, Prifysgol Lerpwl, Lloegr, 1981-2009

Athro Cyngor Ymchwil Feddygol, Prifysgol Lerpwl, Lloegr, 1998-2009

Cyfarwyddwr (Pennaeth) Ysgol Biowyddorau Prifysgol Caerdydd, 2010 - 2015

Athro Cyngor Ymchwil Feddygol, Prifysgol Caerdydd, 2010-2017

Athro yn Ysgol Biowyddorau Caerdydd, 2010 –

Etholiadau i Gymrawd neu Aelod o Academïau (Cymdeithasau) Gwyddoniaeth neu Feddygaeth

Cymrawd y Gymdeithas Frenhinol (FRS). Etholwyd yn 2000. Is-lywydd 2005-2006.

Aelod o Academi Genedlaethol Gwyddorau yr Almaen Leopoldina (ML). Etholwyd yn 2010.

Aelod Anrhydeddus o Academi Gwyddorau Hwngari. Etholwyd yn 2004.

Aelod o Academi Frenhinol Gwyddorau a Llythyrau Denmarc. Etholwyd 1988.

Cymrawd Academi'r Gwyddorau Meddygol (FMedSci). Aelod Sefydlu 1998.

Aelod o Academia Europaea (MAE). Aelod Sefydlu 1988. Is-lywydd 2015 - 2023

Cymrawd Cymdeithas Ddysgedig Cymru (FLSW). Etholwyd yn 2011. Is-lywydd 2014 - 2018.

Cymrawd Coleg Brenhinol y Meddygon (FRCP). Etholwyd yn 2001.

Aelod Anrhydeddus o Gymdeithas yr Almaen ar gyfer Gastroenteroleg, Treulio a Chlefydau Metabolig. Etholwyd yn 2017.

Aelod Anrhydeddus o'r Gymdeithas Ryngwladol Pancreatoleg. Etholwyd 2024.

Aelod Anrhydeddus o'r Clwb Pancreas Ewropeaidd. Etholwyd yn 2022. Llywydd 2003.

Aelod Anrhydeddus o'r Gymdeithas Ffisiolegol. Etholwyd yn 2015. Llywydd 2006 - 2008.

Aelod Anrhydeddus o Gymdeithas Ffisiolegol Hwngari. Etholwyd yn 2002.

Aelod Anrhydeddus o Gymdeithas Ffisiolegol Gwlad Pwyl. Etholwyd 1993.

Anrhydedd Genedlaethol

Cadlywydd Urdd yr Ymerodraeth Brydeinig (CBE) am 'Wasanaethau i Wyddoniaeth'. Gwobr a dderbyniwyd yn bersonol gan y Frenhines Elizabeth II, ym Mhalas Buckingham, 7 Mai 2008.

Gwobrau a Phrif Ddarlithoedd (Detholiad)

Darlith Lawn mewn Symposiwm Rhyngwladol sy'n dathlu 75 mlynedd ers sefydlu Sefydliad y Gwyddorau Bywyd Moleciwlaidd (Sefydliad Ensymoleg gynt), Rhwydwaith Ymchwil Hwngari, Budapest, Hwngari, 31 Mai 2025

Darlith Wobr, Athro Anrhydeddus Nodedig, Prifysgol Al-Ahliyya Amman, Amman, Gwlad yr Iorddonen, 12 Ebrill 2025

Darlith Wobr, XXIII. Cyfarfod o Enillwyr Nobel a Myfyrwyr Talentog, Prifysgol Szeged, Hwngari, 7 Rhagfyr 2024 https://edu-sci.org/konferencia202412/index_eng.html

Darlith Lawn mewn Symposiwm sy'n dathlu '50 mlynedd ers i George Emil Palade dderbyn Gwobr Nobel mewn Ffisioleg neu Feddygaeth', 9 Rhagfyr 2024, Prifysgol Meddygaeth a Fferylliaeth Grigore T Popa, Iasi, Romania

Darlith FEPS (Ffederasiwn Cymdeithasau Ffisiolegol Ewrop), a draddodwyd yng Nghyngres FEPS 'Ffisioleg mewn Ffocws 2023', yn Tallinn, Estonia ar 15 Medi 2023. https://sps-feps-2023.eu/programme/invited-speakers/

Darlith Leopoldina 2023, a gyflwynwyd yn Academi Genedlaethol Gwyddorau yr Almaen Leopoldina, Halle, yr Almaen ar 7 Mawrth 2023

Gwobr a Medal Palade 2022 y Gymdeithas Ryngwladol Pancreatoleg (IAP) (https://internationalpancreatology.org/paladeprize/ ). Traddodwyd Darlith Wobr yng Nghynhadledd ar y Cyd IAP a Chymdeithas Pancreas Japan, a gynhaliwyd yng Nghanolfan Gynadledda Ryngwladol Kyoto, Kyoto, Japan, ar 7 Gorffennaf 2022. Darlith Gwobr Palade: https://doi.org/10.1093/function/zqac061

Cymrawd Undeb Rhyngwladol y Gwyddorau Ffisiolegol (IUPS) ac Aelod Cyntaf (un o ddeg ar hugain ledled y byd) o Academi Ffisioleg IUPS, 2021

Darlith Goffa Syr Michael Berridge Cyntaf, Cynhadledd Calsiwm a Swyddogaeth Celloedd FASEB (rhithwir), 26 Hydref 2021.

Gwobr Medal Aur 2020 Academia Europaea. Derbyniwyd y Fedal Aur gan Lywydd Academia Europaea, a chyflwynwyd y Ddarlith Wobr 'Gwyddoniaeth, cyhoeddi gwyddonol a chyngor gwyddonol ar gyfer polisi: 50 mlynedd o brofiadau personol', yn bersonol, yn 32ain Cynhadledd Flynyddol yr Academi yn Barcelona ar 20 Hydref 2021. Cyhoeddwyd yn European Review (doi: 10.1017/S1062798722000084)

Athro Anrhydeddus ym Mhrifysgol Jinan, Guangzhou, Tsieina. Cyfres o 4 darlith a gyflwynwyd yn Guangzhou ym mis Mawrth 2019.

Gwobr Walter B Cannon 2018 Cymdeithas Ffisiolegol America. Darlith Gwobr Lawn a gyflwynwyd yn Bioleg Arbrofol (EB), Canolfan Confensiwn San Diego, California, 22 Ebrill 2018. Cyhoeddwyd yn Adolygiadau Ffisiolegol 101: 1691-1744, 2021

Darlith Lawn Agoriadol yng Nghyngres Flynyddol Cymdeithas Ffisioleg Brasil 2013. Rebeirao Preto, Sao Paulo, 7 Medi 2013

Darlith Nodedig Horace W Davenport Cymdeithas Ffisiolegol America. Bioleg Arbrofol (EB), Boston, Massachusetts, 23 Ebrill 2013.

Darlith Leopoldina 2012. Traddodwyd yn Academi Genedlaethol Gwyddorau yr Almaen Leopoldina, Halle ar 23 Mai 2012.

Gwobr Cyflawniad Oes. Clwb Pancreatig Ewropeaidd (EPC). Darlith wobr a gyflwynwyd yng Nghyfarfod Blynyddol yr EPC, Stockholm, 17 Mehefin 2010.

Prif Ddarlith Lawn yng Nghyfarfod Blynyddol Cymdeithas Ffisiolegol Corea, Gagneung, De Korea, 30 Hydref 2009.

Darlith Lawn Agoriadol yng Nghynhadledd Gwyddorau Ffisiolegol Beijing 2008. Beijing 20 Hydref 2008.

Prif Ddarlith y Cyfarfod Llawn yn 82ain Cynhadledd Flynyddol Cymdeithas Ffisiolegol Japan, Sendai, Mai 2005.

Medal Anrhydeddus Purkyne am 'Teilyngdod yn y Gwyddorau Biolegol' gan Academi Gwyddorau y Weriniaeth Tsiec. 2003.

Y Brif Ddarlith yng Nghynhadledd Ymchwil Gordon mewn Signalau Calsiwm, South Hadley, Massachusetts, Gorffennaf 2003.

Gwobr Jacobaeus 1994 gan NOVO NORDISK FOUNDATION https://novonordiskfonden.dk/en/prize-recipients/?prize=60696

Anrhydeddau a dyfarniadau

Contact Details

PetersenOH@caerdydd.ac.uk
+44 29208 70846
Adeilad Syr Martin Evans, Ystafell Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX

Athro yn dathlu ei ben-blwydd yn bedwar ugain oed

External profiles

ORCID

Yr Athro Ole Petersen CBE FRS

Timau a rolau for Ole Petersen

Cyfarwyddwr Prifysgol Caerdydd - Canolfan Wybodaeth Academia Europaea

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