Yr Athro David Price

Chair

Yr Ysgol Meddygaeth

Cyhoeddiadau

Date
Type

2024

Giannoni, E. et al. 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54(10), article number: 2451190. (10.1002/eji.202451190)
White, E. et al. 2024. Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1. Nature Immunology 25(9), pp. 1555–1564. (10.1038/s41590-024-01931-9)
Dallan, B. et al. 2024. Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19. Nature Aging 4(8), pp. 1121–1136. (10.1038/s43587-024-00644-w)
Heim, K. et al. 2024. Attenuated effector T cells are linked to control of chronic HBV infection. Nature Immunology 25(9), pp. 1650-1662. (10.1038/s41590-024-01928-4)
Simpson, J. et al. 2024. Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV. JCI Insight 9(14) (10.1172/jci.insight.174168)
Baillie, K. et al. 2024. Complement dysregulation is a prevalent and therapeutically amenable feature of long COVID. Med 5(3), pp. 239-253. (10.1016/j.medj.2024.01.011)
Cabral-Piccin, M. P. et al. 2024. CD8+ T cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy. AIDS 38(2), pp. 161-166. (10.1097/QAD.0000000000003746)

2023

Cai, C. et al. 2023. SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19. Science Immunology 8(90) (10.1126/sciimmunol.adh0687)
Winkler, F. et al. 2023. Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8 + T cells. Gut 72(10), pp. 1971-1984. (10.1136/gutjnl-2022-328734)
Roger, L., Miners, K. L., Leonard, L., Grimstead, J. W., Price, D. A., Baird, D. M. and Ladell, K. 2023. T cell memory revisited using single telomere length analysis. Frontiers in Immunology 14, article number: 1100535. (10.3389/fimmu.2023.1100535)
Knezevic, L. et al. 2023. High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs. Journal of Biological Chemistry 299(8), article number: 104981. (10.1016/j.jbc.2023.104981)
Rubina, A. et al. 2023. ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences 120(33), article number: e2303155120. (10.1073/pnas.2303155120)
Buggert, M., Price, D. A., Mackay, L. K. and Betts, M. R. 2023. Human circulating and tissue-resident memory CD8+ T cells. Nature Immunology 24(7), pp. 1076-1086. (10.1038/s41590-023-01538-6)
Clement, M. et al. 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12, article number: e79165. (10.7554/eLife.79165)
Chen, Y. et al. 2023. Group A Streptococcus induces CD1a-autoreactive T cells and promotes psoriatic inflammation. Science Immunology 8(84), article number: eadd9232. (10.1126/sciimmunol.add9232)
Adamo, S. et al. 2023. Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox. Cell Host & Microbe 31(6), pp. 928-936. (10.1016/j.chom.2023.04.015)
Eser, T. M. et al. 2023. Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion. Nature Communications 14(1), article number: 2952. (10.1038/s41467-023-38020-8)
Fahad, A. S. et al. 2023. Cell activation-based screening of natively paired human T cell receptor repertoires. Scientific Reports 13, article number: 8011. (10.1038/s41598-023-31858-4)
Ciacchi, L. et al. 2023. CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity. Immunity 56(5), pp. 1082-1097. (10.1016/j.immuni.2023.03.020)
Cabral-Piccin, M. P. et al. 2023. Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection. EBioMedicine 91, article number: 104557. (10.1016/j.ebiom.2023.104557)
Shepherd, F. R. et al. 2023. The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells. Communications Biology 6, article number: 78. (10.1038/s42003-023-04420-1)
Proietto, D. et al. 2023. Ageing curtails the diversity and functionality of nascent CD8 + T cell responses against SARS-CoV-2. Vaccines 11(1), article number: 154. (10.3390/vaccines11010154)
Proal, A. D. et al. 2023. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Nature Immunology 24, pp. 1616-1627., article number: 10.1038/s41590-023-01601-2. (10.1038/s41590-023-01601-2)

2022

Fahad, A. S. et al. 2022. Immortalization and functional screening of natively paired human T cell receptor repertoires. Protein Engineering, Design & Selection 35, article number: gzab034. (10.1093/protein/gzab034)
Kemming, J. et al. 2022. Mechanisms of CD8+ T cell failure in chronic hepatitis E virus infection. Journal of Hepatology 77(4), pp. 978-990. (10.1016/j.jhep.2022.05.019)
Goncharov, M. et al. 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19(9), pp. 1017–1019. (10.1038/s41592-022-01578-0)
Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
Pymm, P. et al. 2022. Epitope length variants balance protective immune responses and viral escape in HIV-1 infection. Cell Reports 38(9), article number: 110449. (10.1016/j.celrep.2022.110449)
Nicoli, F. et al. 2022. Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans. The Journal of Immunology 208(3), pp. 562–570. (10.4049/jimmunol.2100194)
Gao, Y. et al. 2022. Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant. Nature Medicine 28(3), pp. 472-476. (10.1038/s41591-022-01700-x)

2021

Campion, S. L. et al. 2021. Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial. Journal of Clinical Investigation 131(23), article number: e150823. (10.1172/JCI150823)
Niessl, J. et al. 2021. Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue. Science Immunology 6(64), article number: eabk0894. (10.1126/sciimmunol.abk0894)
Man, S. et al. 2021. Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells. The Journal of Immunology 207(4), pp. 1009-1017. (10.4049/jimmunol.2000756)
Clement, M. et al. 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118(29), article number: e2019639118. (10.1073/pnas.2019639118)
Heim, K. et al. 2021. TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection. Gut 70, pp. 1550-1560. (10.1136/gutjnl-2020-322404)
Nicoli, F. et al. 2021. Use of a novel peptide welding technology platform for the development of B- and T-Cell epitope-based vaccines. Vaccines 9(5), article number: 526. (10.3390/vaccines9050526)
Hensel, N. et al. 2021. Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection. Nature Immunology 22(2), pp. 229–239. (10.1038/s41590-020-00817-w)
Vlachava, V. et al. 2021. Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus. Journal of Clinical Investigation 131(4), article number: e139296. (10.1172/JCI139296)
Schulien, I. et al. 2021. Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells. Nature Medicine 27(1) (10.1038/s41591-020-01143-2)

2020

Galletti, G. et al. 2020. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans. Nature Immunology 21, pp. 1552-1562. (10.1038/s41590-020-0791-5)
Kasatskaya, S. A. et al. 2020. Functionally specialized human CD4+ T-cell subsets express physicochemically distinct TCRs. eLife 9, article number: e57063. (10.7554/eLife.57063)
Buggert, M. et al. 2020. The identity of human tissue-emigrant CD8+ T cells. Cell 183(7), pp. 1946-1961. (10.1016/j.cell.2020.11.019)
Ahmed, R. et al. 2020. CD57+ Memory T Cells Proliferate In Vivo. Cell Reports 33(11), article number: 108501. (10.1016/j.celrep.2020.108501)
Ghosh, S. et al. 2020. Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency. Blood 136(23), pp. 2638-2655. (10.1182/blood.2020006738)
Narayanan, G. A. et al. 2020. The MAIT TCRβ chain contributes to discrimination of microbial ligand. Immunology and Cell Biology 98(9), pp. 770-781. (10.1111/imcb.12370)
Weinfurter, J. T. et al. 2020. Identifying a minor histocompatibility antigen in mauritian cynomolgus macaques encoded by APOBEC3C. Frontiers in Immunology 11, article number: 586251. (10.3389/fimmu.2020.586251)
Sekine, T. et al. 2020. Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19. Cell 183(1), pp. 158-168. (10.1016/j.cell.2020.08.017)
Passaes, C. et al. 2020. Optimal maturation of the SIV-Specific CD8+ T cell response after primary infection is associated with natural control of SIV: ANRS SIC study. Cell Reports 32(12), article number: 108174. (10.1016/j.celrep.2020.108174)
Papagno, L., Kuse, N., Lissina, A., Gostick, E., Price, D. A., Appay, V. and Nicoli, F. 2020. The TLR9 ligand CpG ODN 2006 is a poor adjuvant for the induction of de novo CD8+ T-cell responses in vitro. Scientific Reports 10(1), article number: 11620. (10.1038/s41598-020-67704-0)
Sekine, T. et al. 2020. TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells. Science Immunology 5(49), article number: eaba7918. (10.1126/sciimmunol.aba7918)
Hanna, S. J. et al. 2020. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype. Diabetologia 63, pp. 1174-1185., article number: Diabetologia volume 63, pages1174–1185(2020). (10.1007/s00125-020-05114-7)
Pearson, F. E. et al. 2020. Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells. Clinical and Translational Immunology 9 (10.1002/cti2.1141)
Edwards, S. C. et al. 2020. A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans. Journal of Experimental Medicine 217(5), article number: e20190834. (10.1084/jem.20190834)
Starke, C. E. et al. 2020. SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues. Journal of Clinical Investigation 130(2), pp. 789-798. (10.1172/JCI129161)
Brenna, E. et al. 2020. CD4+ T follicular helper cells in human tonsils and blood are clonally convergent but divergent from Non-Tfh CD4+ cells. Cell Reports 30(1), pp. 137-152. (10.1016/j.celrep.2019.12.016)
Smith, C. J. et al. 2020. Stochastic expansions maintain the clonal stability of CD8+ T cell populations undergoing memory inflation driven by murine cytomegalovirus. Journal of Immunology 204(1), pp. 112-121. (10.4049/jimmunol.1900455)

2019

Nguyen, S. et al. 2019. Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells. Science Translational Medicine 11(523), article number: eaax4077. (10.1126/scitranslmed.aax4077)
De Simone, G. et al. 2019. CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential. Journal of Immunology 203(12), pp. 3179-3189. (10.4049/jimmunol.1901072)
Appanna, G. D., Pembroke, T. P. I., Miners, K. L., Price, D. A., Gallimore, A. M., Ladell, K. and Godkin, A. J. 2019. Rituximab depletion of intrahepatic B cells to control refractory hepatic autoimmune overlap syndrome. QJM: An International Journal of Medicine 112(10), pp. 793-795. (10.1093/qjmed/hcz161)
Thomas, S. et al. 2019. Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function. Nature Communications 10, pp. -., article number: 4451. (10.1038/s41467-019-12441-w)
Tauber, C. et al. 2019. Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma. Oncotarget 10(50), pp. 5194-5206. (10.18632/oncotarget.27146)
Liu, J. et al. 2019. The peripheral differentiation of human natural killer T cells. Immunology and Cell Biology 97(6), pp. 586-596. (10.1111/imcb.12248)
Wong, E. B. et al. 2019. TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis. Communications Biology 2(1), pp. -., article number: 203. (10.1038/s42003-019-0442-2)
Kemming, J. et al. 2019. ERAP1 allotypes shape the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection. Journal of Hepatology 70(6), pp. 1072-1081. (10.1016/j.jhep.2019.01.034)
Karimzadeh, H. et al. 2019. Mutations in hepatitis D virus allow it to escape detection by CD8+ T Cells and evolve at the population level. Gastroenterology 156(6), pp. 1820-1833. (10.1053/j.gastro.2019.02.003)
Schuch, A. et al. 2019. Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load. Gut 68, pp. 905-915. (10.1136/gutjnl-2018-316641)
Mohammed, R. N. et al. 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9, article number: 5487. (10.1038/s41598-019-41811-z)
Li, N. et al. 2019. Memory CD4+ T cells are generated in the human fetal intestine. Nature Immunology 20, pp. 301-312. (10.1038/s41590-018-0294-9)
Mayassi, T. et al. 2019. Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease. Cell 176(5), pp. 967-981.e19. (10.1016/j.cell.2018.12.039)
McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202(3), pp. 943-955. (10.4049/jimmunol.1701757)
Edwards, E. S. et al. 2019. Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity. Journal of Allergy and Clinical Immunology 143(1), pp. 276-291.e6. (10.1016/j.jaci.2018.04.030)
Shimauchi, T. et al. 2019. Dendritic cells promote the spread of human T-cell leukemia virus type 1 via bidirectional interactions with CD4+ T cells. Journal of Investigative Dermatology 139(1), pp. 157-166. (10.1016/j.jid.2018.06.188)

2018

Nicoli, F. et al. 2018. Naïve CD8+ T-cells engage a versatile metabolic program upon activation in humans and differ energetically from memory CD8+ T-cells. Frontiers in Immunology 9, pp. -., article number: 2736. (10.3389/fimmu.2018.02736)
Boelen, L. et al. 2018. Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1. Science Immunology 3(29), article number: eaao2892. (10.1126/sciimmunol.aao2892)
Powell, W. E. et al. 2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61, pp. 1794-1803. (10.1007/s00125-018-4651-x)
Pogorelyy, M. V. et al. 2018. Exploring the pre-immune landscape of antigen-specific T cells. Genome Medicine 10, article number: 68. (10.1186/s13073-018-0577-7)
Morabito, K. M. et al. 2018. Memory inflation drives tissue-resident memory CD8+ T cell maintenance in the lung after intranasal vaccination with murine cytomegalovirus. Frontiers in Immunology 9, article number: 1861. (10.3389/fimmu.2018.01861)
Costa del Amo, P. et al. 2018. Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness. PLoS Biology 16(6), article number: e2005523. (10.1371/journal.pbio.2005523)
Buggert, M. et al. 2018. Identification and characterization of HIV-specific resident memory CD8 + T cells in human lymphoid tissue. Science Immunology 3(24), article number: eaar4526. (10.1126/sciimmunol.aar4526)
Martin, M. P. et al. 2018. Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. Journal of Clinical Investigation 128(5), pp. 1903. (10.1172/JCI98463)
Wun, K. S. et al. 2018. T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature Immunology 19, pp. 397-406. (10.1038/s41590-018-0065-7)
Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128(4), pp. 1569-1580. (10.1172/JCI91512)
James, E. A. et al. 2018. Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop. Diabetologia 61(3), pp. 658-670. (10.1007/s00125-017-4508-8)
Culina, S. et al. 2018. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Science Immunology 3(20), article number: eaao4013. (10.1126/sciimmunol.aao4013)
Shugay, M. et al. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46(D1), pp. D419-D427. (10.1093/nar/gkx760)
Lissina, A. et al. 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8(1), article number: 2534. (10.1038/s41598-017-18062-x)

2017

Reuter, M. A. et al. 2017. HIV-specific CD8 + T cells exhibit reduced and differentially regulated Cytolytic activity in Lymphoid tissue. Cell Reports 21(12), pp. 3458-3470. (10.1016/j.celrep.2017.11.075)
Van Braeckel-Budimir, N. et al. 2017. A T cell receptor locus harbors a malaria-specific immune response gene. Immunity 47(5), pp. 835-847.e4. (10.1016/j.immuni.2017.10.013)
Culshaw, A. et al. 2017. Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response. Nature Immunology 18, pp. 1228-1237. (10.1038/ni.3850)
Anguille, S. et al. 2017. Dendritic cell vaccination as postremission treatment to prevent or delay relapse in acute myeloid leukemia. Blood 130(15), pp. 1713-1721. (10.1182/blood-2017-04-780155)
Zanon, V. et al. 2017. Curtailed T-cell activation curbs effector differentiation and generates CD8+ T cells with a naturally-occurring memory stem cell phenotype. European Journal of Immunology 47(9), pp. 1468-1476. (10.1002/eji.201646732)
Chen, H. et al. 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95(7), pp. 620-629. (10.1038/icb.2017.21)
Murrell, I. et al. 2017. The pentameric complex drives immunologically covert cell -cell transmission of wild-type human cytomegalovirus. Proceedings of the National Academy of Sciences 114(23), pp. 6104-6109. (10.1073/pnas.1704809114)
Gutjahr, A. et al. 2017. Cutting edge: a dual TLR2 and TLR7 ligand induces highly potent humoral and cell-mediated immune responses. Journal of Immunology 198(11), pp. 4205-4209. (10.4049/jimmunol.1602131)
Pymm, P. et al. 2017. MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nature Structural and Molecular Biology 24, pp. 387-394. (10.1038/nsmb.3381)
Davey, M. S. et al. 2017. Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nature Communications 8, article number: 14760. (10.1038/ncomms14760)
Morabito, K. M., Ruckwardt, T. R., Redwood, A. J., Moin, S. M., Price, D. and Graham, B. S. 2017. Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung. Mucosal Immunology 10(2), pp. 545-554. (10.1038/mi.2016.48)
Smith, C. et al. 2017. Pre-emptive and therapeutic adoptive immunotherapy for nasopharyngeal carcinoma: Phenotype and effector function of T cells impact on clinical response. OncoImmunology 6(2), article number: e1273311. (10.1080/2162402X.2016.1273311)
Dockree, T. et al. 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95(1), pp. 68-76. (10.1038/icb.2016.85)
Abolhassani, H. et al. 2017. Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. Journal of Experimental Medicine 214(1), pp. 91. (10.1084/jem.20160849)

2016

Ahmed, R. et al. 2016. Human stem cell-like memory T cells are maintained in a state of dynamic flux. Cell Reports 17(11), pp. 2811-2818. (10.1016/j.celrep.2016.11.037)
Clement, M. et al. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6, article number: 35332. (10.1038/srep35332)
Watson, H. A. et al. 2016. Purity of transferred CD8+ T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunology and Cell Biology 94(8) (10.1038/icb.2016.45)
Pageon, S. V. et al. 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113(37), pp. E5454-E5463. (10.1073/pnas.1607436113)
Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94(6), pp. 573-582. (10.1038/icb.2016.12)
Caucheteux, S. M. et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136(6), pp. 1172-1181. (10.1016/j.jid.2016.01.033)
de Paula Alves Sousa, A. et al. 2016. Intrathecal T-cell clonal expansions in patients with multiple sclerosis. Annals of Clinical and Translational Neurology 3(6), pp. 422-433. (10.1002/acn3.310)
Pearson, J. A. et al. 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65(6), pp. 1679-1689. (10.2337/db15-1498)
Vinton, C. et al. 2016. Mucosa-associated invariant T cells are systemically depleted in simian immunodeficiency virus-infected rhesus macaques. Journal of Virology 90(9), pp. 4520-4529. (10.1128/JVI.02876-15)
Valkenburg, S. A. et al. 2016. Molecular basis for universal HLA-A*0201 - restricted CD8+ T-cell immunity against influenza viruses. Proceedings of the National Academy of Sciences of the United States of America 113(16), pp. 4440-4445. (10.1073/pnas.1603106113)
Du, V. Y. et al. 2016. HIV-1-specific CD8 T cells exhibit limited cross-reactivity during acute infection. The Journal of Immunology 196(8), pp. 3276-3286. (10.4049/jimmunol.1502411)
Saunders, P. M. et al. 2016. Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition. Journal of Experimental Medicine 213(5), pp. 791-807. (10.1084/jem.20152023)
Ridley, A. et al. 2016. Activation-induced killer cell immunoglobulin-like receptor 3DL2 binding to HLA-B27 licenses pathogenic T cell differentiation in spondyloarthritis. Arthritis and Rheumatology 68(4), pp. 901-914. (10.1002/art.39515)
Jones, K. et al. 2016. The impact of HLA-class I and EBV-latency-II antigen-specific CD8+T-cells on the pathogenesis of EBV+ Hodgkin Lymphoma. Clinical and Experimental Immunology 183(2), pp. 206-220. (10.1111/cei.12716)
Briceño, O. et al. 2016. Reduced naïve CD8+T-cell priming efficacy in elderly adults. Aging Cell 15(1), pp. 14-21. (10.1111/acel.12384)
Lissina, A. et al. 2016. Priming of qualitatively superior human effector CD8+ T cells using TLR8 ligand combined with FLT3 ligand. The Journal of Immunology 196(1), pp. 256-263. (10.4049/jimmunol.1501140)

2015

Holland, C. J. et al. 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195(12), pp. 5827-5836. (10.4049/jimmunol.1402787)
Beringer, D. X. et al. 2015. T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex. Nature Immunology 16, pp. 1153-1161. (10.1038/ni.3271)
Townsley, E. et al. 2015. Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells. Clinical & Experimental Immunology 183(3), pp. 419-430. (10.1111/cei.12722)
Pombo, C., Wherry, E. J., Gostick, E., Price, D. and Betts, M. R. 2015. Elevated expression of CD160 and 2B4 defines a cytolytic HIV-specific CD8+T-cell population in elite controllers. Journal of Infectious Diseases 212(9), pp. 1376-1386. (10.1093/infdis/jiv226)
Ladell, K. et al. 2015. Continuous antigenic stimulation of DO11.10 TCR transgenic mice in the presence or absence of IL-1: possible implications for mechanisms of T cell depletion in HIV disease. Journal of Immunology 195(9), pp. 4096-4105. (10.4049/jimmunol.1500799)
Mohns, M. S. et al. 2015. Expansion of Simian Immunodeficiency Virus (SIV)-specific CD8 T cell lines from SIV-naive Mauritian cynomolgus macaques for adoptive transfer. Journal of Virology 89(19), pp. 9748-9757. (10.1128/JVI.00993-15)
Liuzzi, A. R., McLaren, J. E., Price, D. and Eberl, M. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36, pp. 31-37. (10.1016/j.coi.2015.06.002)
Colbeck, E. et al. 2015. Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors. Oncotarget 6(28), pp. 24649-24659. (10.18632/oncotarget.5584)
Neller, M. A. et al. 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93, pp. 625-633. (10.1038/icb.2015.17)
Schmied, S., Gostick, E., Price, D., Abken, H., Assenmacher, M. and Richter, A. 2015. Analysis of the functional WT1-specific T-cell repertoire in healthy donors reveals a discrepancy between CD4+and CD8+memory formation. Immunology 145(4), pp. 558-569. (10.1111/imm.12472)
Petersen, J. et al. 2015. Determinants of gliadin-specific T cell selection in celiac disease. The Journal of Immunology 194(12), pp. 6112-6122. (10.4049/jimmunol.1500161)
Kloverpris, H. N. et al. 2015. CD8+ TCR bias and immunodominance in HIV-1 infection. The Journal of Immunology 194(11), pp. 5329-5345. (10.4049/jimmunol.1400854)
Motozono, C., Bridgeman, J. S., Price, D., Sewell, A. K. and Ueno, T. 2015. Clonotypically similar hybrid ab T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity. Clinical and Experimental Immunology 180(3), pp. 560-570. (10.1111/cei.12610)
O'Connor, G. M. et al. 2015. Peptide-dependent recognition of HLA-B*57:01 by KIR3DS1. Journal of Virology 89(10), pp. 5213-5221. (10.1128/JVI.03586-14)
Roberto, A. et al. 2015. Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood 125(18), pp. 2855-2864. (10.1182/blood-2014-11-608406)
Skowera, A. et al. 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64(3), pp. 916-925. (10.2337/db14-0332)
Quinn, K. M. et al. 2015. Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling. Journal of Clinical Investigation 125(3), pp. 1129-1146. (10.1172/JCI78280)
Parkinson, N. J. et al. 2015. Violation of the 12/23 rule of genomic V(D)J recombination is common in lymphocytes. Genome Research 25(2), pp. 226-234. (10.1101/gr.179770.114)
Costa, A. I. et al. 2015. Complex T-cell receptor repertoire dynamics underlie the CD8+T-cell response to HIV-1. Journal of Virology 89(1), pp. 110-119. (10.1128/JVI.01765-14)
Nitschke, K. et al. 2015. Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus-specific CD8+T cells in chronic infection. Journal of Virology 89(1), pp. 25-34. (10.1128/JVI.02242-14)

2014

Willis, G. R. et al. 2014. Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles. Human Reproduction 29(12), pp. 2756-2763. (10.1093/humrep/deu281)
Hill, B. J. et al. 2014. Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T Cell populations. The Journal of Immunology 193(11), pp. 5626-5636. (10.4049/jimmunol.1401017)
Pearson, J., Thayer, T. C., McLaren, J. E., Miners, K. L., Ladell, K. I., Price, D. and Wong, F. S. 2014. Analysis of the repertoire of insulin-reactive CD8(+) T cells [Abstract]. Immunology 143(S2), pp. 152-152. (10.1111/imm.12406)
Collins, P. J., Liao, C., Price, D. and Moser, B. 2014. Improving our understanding of CXCL14, one of the few remaining unknowns in chemokine biology [Abstract]. Immunology 143(S2), pp. 85-85. (10.1111/imm.12406)
Connolly, K. D. et al. 2014. Lipoprotein-apheresis reduces circulating microparticles in individuals with familial hypercholesterolemia. Journal of Lipid Research 55, pp. 2064-2072. (10.1194/jlr.M049726)
Taylor, G. S. et al. 2014. A recombinant modified vaccinia Ankara vaccine encoding Epstein-Barr virus (EBV) target antigens: a phase I trial in UK patients with EBV-positive cancer. Clinical Cancer Research 20(19), pp. 5009-5022. (10.1158/1078-0432.CCR-14-1122-T)
Bengsch, B. et al. 2014. Identification of a TSCM phenotype HCV-specific CD8+T cell response with superior functionality in chronic HCV infection [Abstract]. Hepatology 60, pp. 1071A-1072A., article number: 1815.
Kløverpris, H. N. et al. 2014. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load. AIDS 28(14), pp. 2007-2021. (10.1097/QAD.0000000000000362)
Gold, M. C. et al. 2014. MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. Journal of Experimental Medicine 211(8), pp. 1601-1610. (10.1084/jem.20140507)
Dolton, G. M. et al. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177(1), pp. 47-63. (10.1111/cei.12339)
Laydon, D. J. et al. 2014. Quantification of HTLV-1 clonality and TCR diversity. PLoS Computational Biology 10(6), article number: e1003646. (10.1371/journal.pcbi.1003646)
Ondondo, B. et al. 2014. Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cellsviablood vessels and lymphatics. International Journal of Cancer 134(9), pp. 2156-2167. (10.1002/ijc.28556)
Flecken, T. et al. 2014. Immunodominance and functional alterations of tumor-associated antigen-specific CD8+T-cell responses in hepatocellular carcinoma. Hepatology 59(4), pp. 1415-1426. (10.1002/hep.26731)
O'Connor, G. M. et al. 2014. Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity. Journal of Immunology 192(6), pp. 2875-2884. (10.4049/jimmunol.1303142)
Melamed, A. et al. 2014. Clonality of HTLV-2 in natural infection. PLoS Pathogens 10(3), pp. e1004006. (10.1371/journal.ppat.1004006)
Bridgeman, J. S., Ladell, K. I., Sheard, V. E., Miners, K. L., Hawkins, R. E., Price, D. and Gilham, D. E. 2014. CD3ζ-based chimeric antigen receptors mediate T cell activation viacis- andtrans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy. Clinical and Experimental Immunology 175(2), pp. 258-267. (10.1111/cei.12216)
Lissina, A. et al. 2014. The link between CD8+ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate. AIDS 28(4), pp. 477-486. (10.1097/QAD.0000000000000175)

2013

Scurr, M. J. et al. 2013. Highly prevalent colorectal cancer-infiltrating LAP+ Foxp3- T cells exhibit more potent immunosuppressive activity than Foxp3+ regulatory T cells. Mucosal Immunology n/a (10.1038/mi.2013.62)
van den Berg, H. A. et al. 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4, article number: 250. (10.3389/fimmu.2013.00250)
Harris, M. et al. 2013. Acute-Phase CD8 T cell responses that select for escape variants are needed to control live attenuated simian immunodeficiency virus. Journal of Virology 87(16), pp. 9353-9364. (10.1128/JVI.00909-13)
Roux, A. et al. 2013. CMV driven CD8+ T-cell activation is associated with acute rejection in lung transplantation. Clinical Immunology 148(1), pp. 16-26. (10.1016/j.clim.2013.03.012)
Casazza, J. et al. 2013. Therapeutic vaccination expands and improves the function of the HIV-specific memory T-Cell repertoire. International Journal of Infectious Diseases 207(12), pp. 1829-1840. (10.1093/infdis/jit098)
Liu, Y. et al. 2013. Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule. Journal of Biological Chemistry 288(22), pp. 15442-15454. (10.1074/jbc.M112.447185)
Motozono, C. et al. 2013. CD8+ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS ONE 8(6), article number: e66152. (10.1371/journal.pone.0066152)
Budimir, N. et al. 2013. Critical role of TLR7 signaling in the priming of cross-protective Cytotoxic T lymphocyte responses by a whole inactivated influenza virus vaccine. PLoS ONE 8(5), article number: e63163. (10.1371/journal.pone.0063163)
Ladell, K. I. et al. 2013. A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38(3), pp. 425-436. (10.1016/j.immuni.2012.11.021)
Quinn, K. M. et al. 2013. Comparative analysis of the magnitude, quality, phenotype, and protective capacity of simian immunodeficiency virus gag-specific CD8+ T cells following human-, simian-, and chimpanzee-derived recombinant adenoviral vector immunization. The Journal of Immunology 190(6), pp. 2720-2735. (10.4049/jimmunol.1202861)
Lugli, E. et al. 2013. Superior T memory stem cell persistence supports long-lived T cell memory. The Journal of Clinical Investigation 123(2), pp. 594-599. (10.1172/JCI66327)
Greenaway, H. Y., Ng, B., Price, D., Douek, D. C., Davenport, M. P. and Venturi, V. 2013. NKT and MAIT invariant TCRα sequences can be produced efficiently by VJ gene recombination. Immunobiology 218(2), pp. 213-224. (10.1016/j.imbio.2012.04.003)
Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
Koning, D. et al. 2013. CD8+ TCR repertoire formation is guided primarily by the peptide component of the antigenic complex. The Journal of Immunology 190(3), pp. 931-939. (10.4049/jimmunol.1202466)
Chattopadhyay, P. et al. 2013. Holoendemic malaria exposure is associated with altered epstein-barr virus-specific CD8+ T-cell differentiation. Journal of Virology 87(3), pp. 1779-1788. (10.1128/JVI.02158-12)
Iglesias, M. C. et al. 2013. Immunodominance of HLA-B27-restricted HIV KK10-specific CD8+ T-cells is not related to naïve precursor frequency [Letter]. Immunology Letters 149(1-2), pp. 119-122. (10.1016/j.imlet.2012.10.002)
Vavassori, S. et al. 2013. Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. Nature Immunology 14(9), pp. 908-916. (10.1038/ni.2665)
Budimir, N., de Haan, A., Meijerhof, T., Gostick, E., Price, D., Huckriede, A. and Wilschut, J. 2013. Heterosubtypic cross-protection induced by whole inactivated influenza virus vaccine in mice: influence of the route of vaccine administration. Influenza and Other Respiratory Viruses 7(6), pp. 1202-1209. (10.1111/irv.12142)
Beziat, V. et al. 2013. NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRS. Blood 121(14), pp. 2678-2688. (10.1182/blood-2012-10-459545)
Petrovas, C. et al. 2013. High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance. Journal of Virology 87(17), pp. 9836-9844. (10.1128/JVI.01001-13)

2012

Price, D. 2012. Horizons in Medicine 24: molecules, mechanisms and medicines [Editorial]. Clinical Medicine 12(Supp 6), pp. s1. (10.7861/clinmedicine.12-6-s1)
Humphreys, I. R. et al. 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42(12), pp. 3235-3242. (10.1002/eji.201242575)
McCully, M. L., Ladell, K. I., Hakobyan, S., Mansel, R. E., Price, D. and Moser, B. 2012. Epidermis instructs skin homing receptor expression in human T cells. Blood 120(23), pp. 4591-4598. (10.1182/blood-2012-05-433037)
Hindley, J. P. et al. 2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72(21), pp. 5473-5482. (10.1158/0008-5472.CAN-12-1912)
Baum, P. D., Venturi, V. and Price, D. 2012. Wrestling with the repertoire: the promise and perils of next generation sequencing for antigen receptors. European Journal of Immunology 42(11), pp. 2834-2839. (10.1002/eji.201242999)
Ekeruche, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
Ekeruche-Makinde, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
Cole, D. K., Laugel, B., Clement, M., Price, D. A., Wooldridge, L. and Sewell, A. K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137(2), pp. 139-148. (10.1111/j.1365-2567.2012.03625.x)
Li, H. et al. 2012. Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes. Journal of Immunology 189(5), pp. 2404-2413. (10.4049/jimmunol.1102087)
Li, H. et al. 2012. Recombinatorial biases and convergent recombination determine interindividual TCR sharing in murine thymocytes. The Journal of Immunology 189(5), pp. 2404-2413. (10.4049/jimmunol.1102087)
Budde, M. L. et al. 2012. Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques. Journal of Virology 86(14), pp. 7596-7604. (10.1128/JVI.00716-12)
Johnson, M. J. et al. 2012. Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity. The Journal of Immunology 188(12), pp. 6109-6118. (10.4049/jimmunol.1103717)
Johnson, M. J. et al. 2012. Type I IFN induced by adenovirus serotypes 28 and 35 has multiple effects on T cell immunogenicity. Journal of Immunology 188(12), pp. 6109-6118. (10.4049/jimmunol.1103717)
Liddy, N. et al. 2012. Monoclonal TCR-redirected tumor cell killing. Nature Medicine 18(6), pp. 980-987. (10.1038/nm.2764)
Chattopadhyay, P. K. et al. 2012. Brilliant violet fluorophores: A new class of ultrabright fluorescent compounds for immunofluorescence experiments. Cytometry Part A 81A(6), pp. 456-466. (10.1002/cyto.a.22043)
Yamamoto, T. et al. 2012. Virus inhibition activity of effector memory CD8+ T cells determines simian immunodeficiency virus load in vaccinated monkeys after vaccine breakthrough infection. Journal of Virology 86(10), pp. 5877-5884. (10.1128/JVI.00315-12)
Mendoza, D. et al. 2012. HLA B*5701-positive long-term nonprogressors/elite controllers are not distinguished from progressors by the clonal composition of HIV-specific CD8+ T cells. Journal of Virology 86(7), pp. 4014-4018. (10.1128/JVI.06982-11)
Bulek, A. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
Bulek, A. M. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
Cole, D. et al. 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3, article number: 665. (10.1038/ncomms1665)
Janbazian, L. et al. 2012. Clonotype and repertoire changes drive the functional improvement of HIV-specific CD8 T cell populations under conditions of limited antigenic stimulation. The Journal of Immunology 188(3), pp. 1156-1167. (10.4049/jimmunol.1102610)
Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287(2), pp. 1168-1177. (10.1074/jbc.M111.289488)
Budimir, N. et al. 2012. Induction of heterosubtypic cross-protection against influenza by a whole inactivated virus vaccine: the role of viral membrane fusion activity. PLoS ONE 7(1), pp. e30898. (10.1371/journal.pone.0030898)
Bridgeman, J. S., Sewell, A. K., Miles, J. J., Price, D. A. and Cole, D. K. 2012. Structural and biophysical determinants of ab T-cell antigen recognition. Immunology 135(1), pp. 9-18. (10.1111/j.1365-2567.2011.03515.x)
Walker, C. M. et al. 2012. Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted Hepatitis C virus-specific CD8+ T-cell epitope. PLoS Pathogens 8(11), article number: e1003042. (10.1371/journal.ppat.1003042)
Lugli, E., Gattinoni, L., Roberto, A., Mavilio, D., Price, D., Restifo, N. P. and Roederer, M. 2012. Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cell. Nature Protocols 8(1), pp. 33-42. (10.1038/nprot.2012.143)
Doherty, T. M. et al. 2012. A T Cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years. PLoS ONE 7(10), article number: e48322. (10.1371/journal.pone.0048322)
Maloveste, S. M. et al. 2012. Degenerate recognition of MHC class I molecules with Bw4 and Bw6 motifs by a killer cell Ig-like receptor 3DL expressed by macaque NK cells. The Journal of Immunology 189(9), pp. 4338-4348. (10.4049/jimmunol.1201360)

2011

Wu, Y., Gao, F., Liu, J., Qi, J., Gostick, E., Price, D. and Gao, G. F. 2011. Structural basis of diverse peptide accommodation by the rhesus macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus. The Journal of Immunology 187(12), pp. 6382-6392. (10.4049/jimmunol.1101726)
Vivian, J. P. et al. 2011. Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B [Letter]. Nature 479(7373), pp. 401-405. (10.1038/nature10517)
Gattinoni, L. et al. 2011. A human memory T cell subset with stem cell-like properties. Nature Medicine 17(10), pp. 1290-1297. (10.1038/nm.2446)
Iglesias, M. C. et al. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118(8), pp. 2138-2149. (10.1182/blood-2011-01-328781)
Quigley, M. F., Almeida, J. R., Price, D. and Douek, D. C. 2011. Unbiased molecular analysis of T cell receptor expression using template-switch achored RT-PCR. Current Protocols in Immunology, article number: 94:VII:10.33:10.33.1–10.33.16. (10.1002/0471142735.im1033s94)
Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187(2), pp. 654-663. (10.4049/jimmunol.1003941)
Haney, D. et al. 2011. Isolation of viable antigen-specific CD8+ T cells based on membrane-bound tumor necrosis factor (TNF)-α expression. Journal of Immunological Methods 369(1-2), pp. 33-41. (10.1016/j.jim.2011.04.003)
Kreutzman, A. et al. 2011. Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation. Leukemia 25(10), pp. 1587-1597. (10.1038/leu.2011.135)
Hindley, J. P. et al. 2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71(3), pp. 736-746. (10.1158/0008-5472.CAN-10-1797)
Burwitz, B. J. et al. 2011. Simian immunodeficiency virus SIVmac239 nef vaccination elicits different tat28-35SL8-specific CD8+ T-cell clonotypes compared to a DNA prime/adenovirus type 5 boost regimen in rhesus macaques. Journal of Virology 85(7), pp. 3683-3689. (10.1128/JVI.02112-10)
Nagai, K. et al. 2011. Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity. Blood 119(2), pp. 368-376. (10.1182/blood-2011-06-360354)
Minassian, A. M. et al. 2011. A phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults. BMJ Open 1(2), pp. e000223. (10.1136/bmjopen-2011-000223)
Schmidt, J. et al. 2011. Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency. Journal of Virology 85(10), pp. 5232-5236. (10.1128/JVI.00093-11)
Berger, C. T. et al. 2011. High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted gag-derived epitopes associated with relative HIV control. Journal of Virology 85(18), pp. 9334-9345. (10.1128/JVI.00460-11)
O'Connor, S. L. et al. 2011. Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection. Journal of Virology 86(1), pp. 605-609. (10.1128/JVI.05511-11)
Sloand, E. M. et al. 2011. T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy. Blood 117(9), pp. 2691-2699. (10.1182/blood-2010-04-277921)
Yamamoto, T. et al. 2011. Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection. Blood 117(18), pp. 4805-4815. (10.1182/blood-2010-11-317297)
Laugel, B. F., Cole, D., Clement, M., Wooldridge, L., Price, D. and Sewell, A. K. 2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90(6), pp. 1089-1099. (10.1189/jlb.0611316)
Iglesias, M. C. et al. 2011. Escape from highly effective public CD8+ T-cell clonotypes by HIV. Blood 118(8), pp. 2138-2149. (10.1182/blood-2011-01-328781)
Vojnov, L. et al. 2011. GagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo. PLoS ONE 6(8), article number: e23515. (10.1371/journal.pone.0023515)
Ruckwardt, T. J. et al. 2011. Neonatal cd8 t-cell hierarchy is distinct from adults and is influenced by intrinsic t cell properties in respiratory syncytial virus infected mice. PLoS Pathogens 7(12), article number: e1002377. (10.1371/journal.ppat.1002377)
Venturi, V. et al. 2011. A mechanism for TCR sharing between T cell subsets and individuals revealed by pyrosequencing. The Journal of Immunology 186(7), pp. 4285-4294. (10.4049/jimmunol.1003898)
Falkenburg, W. J. J. et al. 2011. Allogeneic HLA-A*02-restricted WT1-specific T cells from mismatched donors are highly reactive but show off-target promiscuity. The Journal of Immunology 187(5), pp. 2824-2833. (10.4049/jimmunol.1100852)
Miles, J. J., Douek, D. C. and Price, D. 2011. Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination. Immunology and Cell Biology 89(3), pp. 375-387. (10.1038/icb.2010.139)

2010

van Bockel, D. J. et al. 2010. Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response. The Journal of Immunology 186(1), pp. 359-371. (10.4049/jimmunol.1001807)
Quigley, M. F. et al. 2010. Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire. Proceedings of the National Academy of Sciences of the United States of America 107(45), pp. 19414-19419. (10.1073/pnas.1010586107)
Humphreys, I. R. et al. 2010. Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells. European Journal of Immunology 40(10), pp. 2762-2768. (10.1002/eji.200940256)
Jones, M. et al. 2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185(6), pp. 3583-3592. (10.4049/jimmunol.1001535)
Cole, D. et al. 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185(4), pp. 2600-2610. (10.4049/jimmunol.1000629)
Rosario, M. et al. 2010. Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques. European Journal of Immunology 40(7), pp. 1973-1984. (http://dx.doi.org/10.1002/eji.201040344)
Greene, J. M. et al. 2010. Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239 nef-vaccinated macaques suppress SIVmac239 replication ex vivo. Journal of Virology 84(7), pp. 3362-3372. (10.1128/JVI.02028-09)
Wooldridge, L., Laugel, B. F., Ekeruche, J., Clement, M., van den Berg, H. A., Price, D. and Sewell, A. K. 2010. CD8 controls T cell cross-reactivity. The Journal of Immunology 185(8), pp. 4625-4632. (10.4049/jimmunol.1001480)
Chattopadhyay, P. K., Roederer, M. and Price, D. A. 2010. OMIP-002: Phenotypic analysis of specific human CD8+ T-cells using peptide-MHC class I multimers for any of four epitopes. Cytometry Part A 77A(9), pp. 821-822. (10.1002/cyto.a.20945)
Schaubert, K. L. et al. 2010. Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. European Journal of Immunology 40(7), pp. 1950-1962. (10.1002/eji.200940079)
Wooldridge, L. et al. 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184(7), pp. 3357-3366. (10.4049/jimmunol.0902398)
Van Tendeloo, V. F. et al. 2010. Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination. Proceedings of the National Academy of Sciences of the United States of America 107(31), pp. 13824-13829. (10.1073/pnas.1008051107)
Giannopoulos, K. et al. 2010. Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia. Leukemia 24(4), pp. 798-805. (10.1038/leu.2010.29)
Rosario, M. et al. 2010. Novel recombinant mycobacterium bovis BCG, ovine atadenovirus, and modified vaccinia virus ankara vaccines combine to induce robust human immunodeficiency virus-specific CD4 and CD8 T-cell responses in rhesus macaques. Journal of Virology 84(12), pp. 5898-5908. (10.1128/JVI.02607-09)
Harris, L. D. et al. 2010. Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood 116(20), pp. 4148-4157. (10.1182/blood-2010-05-283549)
Melenhorst, J. J. et al. 2010. Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects. Blood 116(22), pp. 4700-4702. (10.1182/blood-2010-06-289991)
Miles, J. J. et al. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6(11), article number: e1001198. (10.1371/journal.ppat.1001198)
Subramanya, S. et al. 2010. Enhanced induction of HIV-specific Cytotoxic T Lymphocytes by Dendritic cell-targeted delivery of SOCS-1 siRNA. Molecular Therapy 18(11), pp. 2028-2037. (10.1038/mt.2010.148)

2009

Burwitz, B. J. et al. 2009. P20-16. Ultra-deep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in SIV-infected macaques. Retrovirology 6(S3), article number: P386. (10.1186/1742-4690-6-S3-P386)
Price, D. A. et al. 2009. Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection. Journal of Experimental Medicine 206(4), pp. 923-936. (10.1084/jem.20081127)
Melenhorst, J. J. et al. 2009. High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow. Blood 113(10), pp. 2238-2244. (10.1182/blood-2008-04-151969)
Bimber, B. N. et al. 2009. Ultradeep pyrosequencing detects complex patterns of CD8+ T-lymphocyte escape in simian immunodeficiency virus-infected macaques. Journal of Virology 83(16), pp. 8247-8253. (10.1128/JVI.00897-09)
Lissina, A. et al. 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340(1), pp. 11-24. (10.1016/j.jim.2008.09.014)
Almeida, J. et al. 2009. P16-17. Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV suppressive activity. Retrovirology 6(3), article number: P246. (10.1186/1742-4690-6-S3-P246)
Cole, D. et al. 2009. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry 284(40), article number: 27281-27289. (10.1074/jbc.M109.022509)
Wooldridge, L., Lissina, A., Cole, D., van den Berg, H. A., Price, D. and Sewell, A. K. 2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126(2), pp. 147-164. (10.1111/j.1365-2567.2008.02848.x)
Geldmacher, C. et al. 2009. Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response. Blood 114(8), pp. 1553-1562. (10.1182/blood-2009-02-206193)
Almeida, J. R. et al. 2009. Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity. Blood 113(25), pp. 6351-6360. (10.1182/blood-2009-02-206557)
Scheinberg, P. et al. 2009. The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor. Blood 114(24), pp. 5071-5080. (10.1182/blood-2009-04-214684)
Chattopadhyay, P. K., Betts, M. R., Price, D., Gostick, E., Horton, H., Roederer, M. and De Rosa, S. C. 2009. The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression. Journal of Leukocyte Biology 85(1), pp. 88-97. (10.1189/jlb.0208107)
Nakamoto, N. et al. 2009. Synergistic reversal of intrahepatic hcv-specific cd8 t cell exhaustion by combined pd-1/ctla-4 blockade. PLoS Pathogens 5(2), article number: e1000313. (10.1371/journal.ppat.1000313)
Petrovas, C. et al. 2009. Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection. The Journal of Immunology 183(2), pp. 1120-1132. (10.4049/jimmunol.0900182)
Honda, M. et al. 2009. Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity. The Journal of Immunology 183(4), pp. 2425-2434. (10.4049/jimmunol.0900581)
Greenaway, H. Y., Kurniawan, M., Price, D., Douek, D. C., Davenport, M. P. and Venturi, V. 2009. Extraction and characterization of the rhesus macaque T-cell receptor β-chain genes. Immunology and Cell Biology 87(7), pp. 546-553. (10.1038/icb.2009.38)

2008

Venturi, V. et al. 2008. TCR β-Chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV. Journal of Immunology 181(11), pp. 7853-7862. (10.4049/jimmunol.181.11.7853)
Melenhorst, J. J. et al. 2008. Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of Immunological Methods 338(1-2), pp. 31-39. (10.1016/j.jim.2008.07.008)
Ebinuma, H. et al. 2008. Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection. Journal of Virology 82(10), pp. 5043-5053. (10.1128/JVI.01548-07)
Rehr, M. et al. 2008. Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy. Journal of Virology 82(7), pp. 3391-3404. (10.1128/JVI.02383-07)
Weichsel, R. et al. 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Research 14(8), pp. 2484-2491. (10.1158/1078-0432.CCR-07-4393)
Price, D., Bitmansour, A. D., Edgar, J. B., Walker, J. M., Axthelm, M. K., Douek, D. C. and Picker, L. J. 2008. Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques. Journal of Immunology 180(1), pp. 269-280. (10.4049/jimmunol.180.1.269)
Melenhorst, J. J. et al. 2008. Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoire. Journal of Immunology 180(10), pp. 6484-6489.
Venturi, V., Chin, H. Y., Price, D. A., Douek, D. C. and Davenport, M. P. 2008. The role of production frequency in the sharing of simian immunodeficiency virus-specific CD8+ TCRs between macaques. Journal of Immunology 181(4), pp. 2597-2609. (10.4049/jimmunol.181.4.2597)
Chattopadhyay, P. K. et al. 2008. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+T cells with peptide-major histocompatibility complex class I tetramers. Cytometry Part A 73A(11), pp. 1001-1009. (10.1002/cyto.a.20642)
Reynolds, M. R. et al. 2008. Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. Journal of Experimental Medicine 205(11), pp. 2537-2550. (10.1084/jem.20081524)
Nakamoto, N. et al. 2008. Functional restoration of HCV-specific CD8 T Cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134(7), pp. 1927-1937. (10.1053/j.gastro.2008.02.033)
Smith, M. Z., Asher, T. E., Venturi, V., Davenport, M. P., Douek, D. C., Price, D. and Kent, S. J. 2008. Limited maintenance of vaccine-induced simian immunodeficiency virus-specific CD8 T-cell receptor clonotypes after virus challenge. Journal of Virology 82(15), pp. 7357-7368. (10.1128/JVI.00607-08)
Daucher, M. et al. 2008. Virological outcome after structured interruption of antiretroviral therapy for human immunodeficiency virus infection is associated with the functional profile of virus-specific CD8+ T cells. Journal of Virology 82(8), pp. 4102-4114. (10.1128/JVI.02212-07)
Mielke, S. et al. 2008. A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique. Blood 111(8), pp. 4392-4402. (10.1182/blood-2007-08-104471)
Brenchley, J. M. et al. 2008. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood 112(7), pp. 2826-2835. (10.1182/blood-2008-05-159301)
Hestvik, A. L. K., Skorstad, G., Price, D., Vartdal, F. and Holmoy, T. 2008. Multiple sclerosis: glatiramer acetate induces anti-inflammatory T cells in the cerebrospinal fluid. Multiple Sclerosis Journal 14(6), pp. 749-758. (10.1177/1352458508089411)
Appay, V., Douek, D. C. and Price, D. 2008. CD8+ T cell efficacy in vaccination and disease. Nature Medicine 14(6), pp. 623-628. (10.1038/nm.f.1774)
Venturi, V., Price, D., Douek, D. C. and Davenport, M. P. 2008. The molecular basis for public T-cell responses?. Nature Reviews Immunology 8(3), pp. 231-238. (10.1038/nri2260)
Brenchley, J. M. et al. 2008. High frequencies of polyfunctional HIV-specific T cells are associated with preservation of mucosal CD4 T cells in bronchoalveolar lavage. Mucosal Immunology 1(1), pp. 49-58. (10.1038/mi.2007.5)
Melenhorst, J. J. et al. 2008. Contribution of TCR- locus and HLA to the shape of the mature human V repertoire. The Journal of Immunology 180(10), pp. 6484-6489. (10.4049/jimmunol.180.10.6484)
Seggewiss, R., Price, D. and Purbhoo, M. 2008. Immunomodulatory effects of imatinib and second-generation tyrosine kinase inhibitors on T cells and dendritic cells: an update. Cytotherapy 10(6), pp. 633-641. (10.1080/14653240802317639)
Melenhorst, J. et al. 2008. Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture. Cytotherapy 10(2), pp. 152-164. (10.1080/14653240701853536)

2007

Loffredo, J. T. et al. 2007. Cd8+ T cells from siv elite controller macaques recognize mamu-b*08-bound epitopes and select for widespread viral variation. PLoS ONE 2(11), article number: e1152. (10.1371/journal.pone.0001152)
Laugel, B. F. et al. 2007. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotxic T lymphocyte activation and tetramer properties. The Journal of Biological Chemistry 282(33), pp. 23799-22810. (10.1074/jbc.M700976200)
Cole, D. et al. 2007. Human TCR-binding affinity is governed by MHC class restriction. The Journal of Immunology 178(9), pp. 5727-5734. (10.4049/jimmunol.178.9.5727)
Wooldridge, L. et al. 2007. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. European Journal of Immunology 37(5), pp. 1323-1333. (10.1002/eji.200636765)
Scheinberg, P., Melenhorst, J. J., Hill, B. J., Keyvanfar, K., Barrett, A. J., Price, D. and Douek, D. C. 2007. The clonal composition of human CD4+CD25+Foxp3+ cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements. Journal of Immunological Methods 321(1-2), pp. 107-120. (10.1016/j.jim.2007.01.005)
Gostick, E. et al. 2007. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. European Journal of Immunology 37(2), pp. 479-486. (10.1002/eji.200636243)
Maness, N. J. et al. 2007. AIDS virus-specific CD8+T lymphocytes against an immunodominant cryptic epitope select for viral escape. Journal of Experimental Medicine 204(11), pp. 2505-2512. (10.1084/jem.20071261)
Beveridge, N. et al. 2007. Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctionalMycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. European Journal of Immunology 37(11), pp. 3089-3100. (10.1002/eji.200737504)
Almeida, J. R. et al. 2007. Superior control of HIV-1 replication by CD8+T cells is reflected by their avidity, polyfunctionality, and clonal turnover. Journal of Experimental Medicine 204(10), pp. 2473-2485. (10.1084/jem.20070784)
Yuan, F. et al. 2007. Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 63(9), pp. 758-760. (10.1107/S1744309107037244)
van Bockel, D. et al. 2007. Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood. Journal of Immunological Methods 326(1-2), pp. 127-138. (10.1016/j.jim.2007.07.016)
Rezvani, K. et al. 2007. Graft-versus-leukemia effects associated with detectable Wilms tumor-1-specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia. Blood 110(6), pp. 1924-1932. (10.1182/blood-2007-03-076844)
Purbhoo, M. A. et al. 2007. The HLA A*0201-restricted hTERT540-548 peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor. Molecular Cancer Therapeutics 6(7), pp. 2081-2091. (10.1158/1535-7163.MCT-07-0092)
Petrovas, C. et al. 2007. SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110(3), pp. 928-936. (10.1182/blood-2007-01-069112)
Schaubert, K. L. et al. 2007. Availability of a diversely Avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 gag p2419-27 epitope. The Journal of Immunology 178(12), pp. 7756-7766. (10.4049/jimmunol.178.12.7756)
Precopio, M. L. et al. 2007. Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+T cell responses. Journal of Experimental Medicine 204(6), pp. 1405. (10.1084/jem.20062363)
Davenport, M., Price, D. and McMichael, A. 2007. The T cell repertoire in infection and vaccination: implications for control of persistent viruses. Current Opinion in Immunology 19(3), pp. 294-300. (10.1016/j.coi.2007.04.001)
Laugel, B., Price, D., Milicic, A. and Sewell, A. K. 2007. CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. European Journal of Immunology 37(4), pp. 905-913. (10.1002/eji.200636718)
Hryniewicz, A. et al. 2007. Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virusmac251-infected macaques. The Journal of Immunology 178(6), pp. 3492-3504. (10.4049/jimmunol.178.6.3492)

2006

Price, D., Silvestri, G., Brenchley, J. and Asher, T. 2006. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nature Medicine 12(12), pp. 1365-71. (10.1038/nm1511)
Chattopadhyay, P. K. et al. 2006. Quantum dot semiconductor nanocrystals for immunophenotyping by polychomatic flow cytometry. Nature Medicine 12(8), pp. 972-7. (10.1038/nm1371)
Wooldridge, L. et al. 2006. Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. European Journal of Immunology 36(7), pp. 1847-1855. (10.1002/eji.200635886)
Casazza, J. P. et al. 2006. Acquisition of direct antiviral effector functions by CMV-specific CD4+T lymphocytes with cellular maturation. Journal of Experimental Medicine 203(13), pp. 2865-2877. (10.1084/jem.20052246)
Venturi, V., Kedzierska, K., Price, D., Doherty, P. C., Douek, D. C., Turner, S. J. and Davenport, M. P. 2006. Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination. Proceedings of the National Academy of Sciences of the United States of America 103(49), pp. 18691-18696. (10.1073/pnas.0608907103)
Leslie, A. et al. 2006. Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. The Journal of Immunology 177(7), pp. 4699-4708. (10.4049/jimmunol.177.7.4699)
Petrovas, C. et al. 2006. PD-1 is a regulator of virus-specific CD8+T cell survival in HIV infection. Journal of Experimental Medicine 203(10), pp. 2281-2292. (10.1084/jem.20061496)
Brenchley, J. M., Ruff, L. E., Casazza, J. P., Koup, R. A., Price, D. and Douek, D. C. 2006. Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo. Journal of Virology 80(14), pp. 6801-6809. (10.1128/JVI.00070-06)
Laugel, B., Price, D. and Sewell, A. K. 2006. On the path to TCR-directed therapeutics. Nature Biotechnology 24(6), pp. 615-616. (10.1038/nbt0606-615b)
Scheinberg, P., Price, D., Ambrozak, D. R., Barrett, A. J. and Douek, D. C. 2006. Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: Implications for graft engineering. Experimental Hematology 34(6), pp. 788-795. (10.1016/j.exphem.2006.03.001)
Kan-Mitchell, J. et al. 2006. Degeneracy and repertoire of the Human HIV-1 Gag p1777-85 CTL Response. The Journal of Immunology 176(11), pp. 6690-6701. (10.4049/jimmunol.176.11.6690)
Brenchley, J. M., Price, D. and Douek, D. C. 2006. HIV disease: fallout from a mucosal catastrophe?. Nature Immunology 7(3), pp. 235-239. (10.1038/ni1316)

2005

Price, D. et al. 2005. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. Journal of Experimental Medicine 202(10), pp. 1349-61. (10.1084/jem.20051357)
Wooldridge, L. et al. 2005. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. The Journal of Biological Chemistry 280(30), pp. 27491-27501. (10.1074/jbc.M500555200)
Laugel, B. et al. 2005. Design of soluble recombinant T Cell receptors for antigen targeting and T cell inhibition. Journal of Biological Chemistry 280(3), pp. 1882-1892. (10.1074/jbc.M409427200)
Rezvani, K. et al. 2005. T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization.. Clinical Cancer Research 11(24), pp. 8799-8807. (10.1158/1078-0432.CCR-05-1314)
Milicic, A. et al. 2005. CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef. The Journal of Immunology 175(7), pp. 4618-4626. (10.4049/jimmunol.175.7.4618)
Joos, B. et al. 2005. Low human immunodeficiency virus envelope diversity correlates with low in vitro replication capacity and predicts spontaneous control of plasma viremia after treatment interruptions. Journal of Virology 79(14), pp. 9026-9037. (10.1128/JVI.79.14.9026-9037.2005)
Fujiwara, H. et al. 2005. In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins. Clinical Cancer Research 11(12), pp. 4495-4503. (10.1158/1078-0432.CCR-04-2363)
Betts, M. R. et al. 2005. Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection. Proceedings of the National Academy of Sciences of the United States of America 102(12), pp. 4512-4517. (10.1073/pnas.0408773102)
Seggewiss, R. et al. 2005. Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 105(6), pp. 2473-2479. (10.1182/blood-2004-07-2527)
Casazza, J. P., Betts, M. R., Hill, B. J., Brenchley, J. M., Price, D., Douek, D. C. and Koup, R. A. 2005. Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapy. Journal of Virology 79(6), pp. 3653-3663. (10.1128/JVI.79.6.3653-3663.2005)
Ellmerich, S. et al. 2005. High incidence of spontaneous disease in an HLA-DR15 and TCR transgenic multiple sclerosis model. The Journal of Immunology 174(4), pp. 1938-1946. (10.4049/jimmunol.174.4.1938)
Hewitt, R. E., Lissina, A., Green, A. E., Slay, E. S., Price, D. and Sewell, A. K. 2005. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clinical and Experimental Immunology 139(1), pp. 101-111. (10.1111/j.1365-2249.2005.02665.x)

2004

Price, D. et al. 2004. T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity 21(6), pp. 793-803. (10.1016/j.immuni.2004.10.010)
Green, A. E. et al. 2004. Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin. Clinical & Experimental Immunology 136(3), pp. 472-482. (10.1111/j.1365-2249.2004.02472.x)
Brenchley, J. M. et al. 2004. T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. Journal of Virology 78(3), pp. 1160-1168. (10.1128/JVI.78.3.1160-1168.2004)
Brenchley, J. M. et al. 2004. CD4+T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. Journal of Experimental Medicine 200(6), pp. 749-759. (10.1084/jem.20040874)
Scherer, A. et al. 2004. Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS. Proceedings of the National Academy of Sciences of the United States of America 101(33), pp. 12266-12270. (10.1073/pnas.0404091101)
Oxenius, A. et al. 2004. Loss of viral control in early HIV-1 infection Is temporally associated with sequential escape from CD8+ T cell responses and decrease in HIV-1-specific CD4+ and CD8+ T cell frequencies. International Journal of Infectious Diseases 190(4), pp. 713-721. (10.1086/422760)
Crawford, M. P. et al. 2004. High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay. Blood 103(11), pp. 4222-4231. (10.1182/blood-2003-11-4025)
Betts, M. R. et al. 2004. The functional profile of primary human antiviral CD8+ T cell effector activity is dictated by cognate peptide concentration. The Journal of Immunology 172(10), pp. 6407-6417. (10.4049/jimmunol.172.10.6407)
Fujiwara, H. et al. 2004. Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase. Blood 103(8), pp. 3076-3083. (10.1182/blood-2003-07-2424)
Oxenius, A. et al. 2004. HIV-specific cellular immune response is inversely correlated with disease progression as defined by decline of CD4+T cells in relation to HIV RNA load. International Journal of Infectious Diseases 189(7), pp. 1199-1208. (10.1086/382028)

2003

Wooldridge, L. et al. 2003. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J Immunol 171, pp. 6650-60.
Jones, E., Price, D., Dahm-Vicker, M., Cerundolo, V., Klenerman, P. and Gallimore, A. 2003. The influence of macrophage inflammatory protein-1alpha on protective immunity mediated by antiviral cytotoxic T cells. Immunology 109(1), pp. 68-75. (10.1046/j.1365-2567.2003.01636.x)
Price, D. et al. 2003. Discordant outcomes following failure of antiretroviral therapy are associated with substantial differences in human immunodeficiency virus-specific cellular immunity. Journal of Virology 77(10), pp. 6041-6049. (10.1128/JVI.77.10.6041-6049.2003)
Brookes, R. H., Pathan, A. A., McShane, H., Hensmann, M., Price, D. and Hill, A. V. S. 2003. CD8+ T cell-mediated suppression of intracellularMycobacterium tuberculosis growth in activated human macrophages. European Journal of Immunology 33(12), pp. 3293-3302. (10.1002/eji.200324109)
Betts, M. R., Brenchley, J. M., Price, D., De Rosa, S. C., Douek, D. C., Roederer, M. and Koup, R. A. 2003. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. Journal of Immunological Methods 281(1-2), pp. 65-78. (10.1016/S0022-1759(03)00265-5)
Rezvani, K. et al. 2003. Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation. Blood 102(8), pp. 2892-2900. (10.1182/blood-2003-01-0150)
Hutchinson, S. L. et al. 2003. The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. Journal of Biological Chemistry 278(27), pp. 24285-24293. (10.1074/jbc.M300633200)
Fagard, C. et al. 2003. A prospective trial of structured treatment interruptions in human immunodeficiency virus infection. Archives of Internal Medicine 163(10), pp. 1220-1226. (10.1001/archinte.163.10.1220)

2002

Oxenius, A. et al. 2002. Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection. Proceedings of the National Academy of Sciences of the United States of America 99(21), pp. 13747-13752. (10.1073/pnas.202372199)
Oxenius, A. et al. 2002. Human Immunodeficiency Virus-specific CD8+ T-Cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy. Journal of Virology 76(20), pp. 10169-10176. (10.1128/JVI.76.20.10169-10176.2002)
Glick, M. et al. 2002. Novel CD8+ T cell antagonists based on 2-Microglobulin. Journal of Biological Chemistry 277(23), pp. 20840-20846. (10.1074/jbc.M201819200)
Douek, D. C. et al. 2002. HIV preferentially infects HIV-specific CD4+ T cells. Nature 417(6884), pp. 95-98. (10.1038/417095a)
Kelleher, A. D., Sewell, A. K. and Price, D. 2002. Dyslipidemia due to retroviral protease inhibitors [Letter]. Nature Medicine 8(4), pp. 308. (10.1038/nm0402-308a)

2001

Altes, H. K., Price, D. and Jansen, V. A. 2001. Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV. Vaccine 20(1-2), pp. 3-6. (10.1016/S0264-410X(01)00318-8)
Oxenius, A., Price, D., Dawson, S. J., Tun, T., Easterbrook, P. J., Phillips, R. E. and Sewell, A. K. 2001. Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens. AIDS 15(1), pp. 121-122. (10.1097/00002030-200101050-00018)
Purbhoo, M. A. et al. 2001. The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor chain. Journal of Biological Chemistry 276(35), pp. 32786-32792. (10.1074/jbc.M102498200)
Karadimitris, A. et al. 2001. Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proceedings of the National Academy of Sciences of the United States of America 98(6), pp. 3294-3298. (10.1073/pnas.051604498)
Sewell, A. K. and Price, D. 2001. Dendritic cells and transmission of HIV-1. Trends in Immunology 22(4), pp. 173-175. (10.1016/S1471-4906(01)01866-X)

2000

Phillips, R. E., Oxenius, A., Price, D. and Bangham, C. R. 2000. AIDS: the evolving story. Trends in Microbiology 8(4), pp. 147-148. (10.1016/S0966-842X(00)01706-6)
Oxenius, A. et al. 2000. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 97(7), pp. 3382-3387. (10.1073/pnas.97.7.3382)

1999

Price, D., Klenerman, P., Booth, B. L., Phillips, R. E. and Sewell, A. K. 1999. Cytotoxic T lymphocytes, chemokines and antiviral immunity. Immunology Today 20(5), pp. 212-216. (10.1016/S0167-5699(99)01447-4)
Sewell, A. K. et al. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5, pp. 399-404. (10.1038/7398)

1998

Lewis, J. W., Sewell, A. K., Price, D. and Elliot, T. 1998. HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. European Journal of Immunology 28, pp. 3214-3220.
Price, D., Sewell, A. K., Dong, T., Tan, R., Goulder, P. J. R., Rowland-Jones, S. L. and Phillips, R. E. 1998. Antigen-specific release of b-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Current Biology 8(6), pp. 355-358. (10.1016/S0960-9822(98)70138-1)

1997

Goulder, P., Price, D., Nowak, M., Rowland-Jones, S., Phillips, R. and McMichael, A. 1997. Co-evolution of human immunodeficiency virus and cytotoxic T-lymphocyte responses. Immunological Reviews 159(1), pp. 17-29. (10.1111/j.1600-065X.1997.tb01004.x)
Sewell, A. K., Harcourt, G. C., Goulder, P. J. R., Price, D. and Phillips, R. E. 1997. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. European Journal of Immunology 27(9), pp. 2323-2329. (10.1002/eji.1830270929)
Goulder, P. J. R., Reid, S. W., Price, D., O'Callaghan, C. A., McMichael, A. J., Phillips, R. E. and Jones, E. Y. 1997. Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T lymphocyte epitopes. European Journal of Immunology 27(6), pp. 1515-1521. (10.1002/eji.1830270630)
Price, D. et al. 1997. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proceedings of the National Academy of Sciences 94(5), pp. 1890-1895. (10.1073/pnas.94.5.1890)
Goulder, P. et al. 1997. Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation. Journal of Experimental Medicine 185(8), pp. 1423-1433. (10.1084/jem.185.8.1423)

1995

Teare, J. P., Price, D., Foster, G. R., McBride, M., Goldin, R. D. and Main, J. 1995. Reversible AIDS-related sclerosing cholangitis. Journal of Hepatology 23(2), pp. 209-211. (10.1016/0168-8278(95)80337-8)

1994

Price, D., Hollings, N. P., Janes, S. M., Main, J. and Coker, R. J. 1994. Clinical response to the addition of clarithromycin in Pneumocystis carinii pneumonia refractory to high dose co-trimoxazole. Journal of Antimicrobial Chemotherapy 34(2), pp. 303. (10.1093/jac/34.2.303)

Contact Details

PriceD6@caerdydd.ac.uk
+44 29206 87002

Targedu llid er mwyn mynd i’r afael â COVID hir

Targedu llid er mwyn mynd i’r afael â COVID hir

14 February 2024

Prifysgol Caerdydd yn cael cyllid sylweddol i ymchwilio i COVID hir

Prifysgol Caerdydd yn cael cyllid sylweddol i ymchwilio i COVID hir

18 July 2021