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Dr Neil Rodrigues
DPhil (Oxon)
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Neil Rodrigues
Darllenydd, Tiwtor Adrannol Ôl-raddedig
Ysgol y Biowyddorau
Trosolwyg
My laboratory is interested in haematopoietic stem/progenitor cell biology and their dysregulation in bone marrow failure and haematologic cancer. We are investigating the transcriptional and post-transcriptional mechanisms regulating haematopoietic stem/progenitor cells, myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) with the ultimate purpose of identifying more specific and less toxic treatment strategies for MDS and AML.
Lab staff
- Dr Gui Jie Feng, Research Associate
- Dr Juan Menendez Gonzalez, Research Associate
- Dr. Marwa Abu-Serie, Visiting Research Associate
- Alhomidi Almotiri (PhD student)
- Amani Alsayari (PhD student)
- Ali Abdelfattah, PhD student
- Leigh-Anne Thomas, PhD student
- Badi Alotaibi, PhD student
- Hamed Ahmad A Alzahrani, PhD student
- Emma Wilde, MRes student
Current grant support
- Sêr Cymru National Research Network in Health and Life Sciences
- Leukaemia Cancer Society
- British Society for Haematology
- Cancer Research UK Cardiff Centre (Development Fund)
- Sêr Cymru Richard Whipp Studentships
- Royal Embassy of Saudi Arabia
Cyhoeddiad
2026
- Abdelfattah, A. et al. 2026. Worldwide prevalence of Helicobacter pylori in patients with Mucosa-associated lymphoid tissue (MALT) lymphomas: A systematic review and meta-analysis. Acta Biomedica 97 (1) 17906. (10.23750/abm.2026.17906)
- Derrac Soria, A. et al. 2026. IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis. null (10.1101/2024.09.03.610972)
2025
- Abdelfattah, A. et al. 2025. Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency. Stem Cell Reports 20 (8) 102596. (10.1016/j.stemcr.2025.102596)
- Almotiri, A. et al. 2025. Treating genetic blood disorders in the era of CRISPR-mediated genome editing. Molecular Therapy 33 (6), pp.2645-2662. (10.1016/j.ymthe.2025.01.031)
2024
- Almotiri, A. et al. 2024. Zeb1 maintains long-term adult hematopoietic stem cell function and extramedullary hematopoiesis. Experimental Hematology 134 104177. (10.1016/j.exphem.2024.104177)
2023
- Almotiri, A. , Boyd, A. S. and Rodrigues, N. P. 2023. Zeb1 Regulates the function of lympho-myeloid primed progenitors after transplantation. Biomolecules 13 (9) 1386. (10.3390/biom13091386)
- Chan, Y. et al. 2023. (+)-catechin attenuates multiple atherosclerosis-associated processes in vitro, modulates disease-associated risk factors in C57BL/6J mice and reduces atherogenesis in LDL receptor deficient mice by inhibiting inflammation and increasing markers of plaque stability. Molecular Nutrition & Food Research 67 (14) 2200716. (10.1002/mnfr.202200716)
- Rastogi, N. et al. 2023. Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia. Leukemia 37 , pp.276-287. (10.1038/s41375-022-01801-z)
2022
- Menendez-Gonzalez, J. B. et al., 2022. Ligand-based discovery of a novel GATA2 inhibitor targeting acute myeloid leukemia cells. Frontiers In Drug Discovery 2 1013229. (10.3389/fddsv.2022.1013229)
- Almotiri, A. , Abdelfattah, A. and Rodrigues, N. P. 2022. Flow cytometry analysis of hematopoietic stem/progenitor cells and mature blood cell subsets in atherosclerosis. In: Ramji, D. ed. Atherosclerosis. Vol. 2419, Methods in Molecular Biology Springer. , pp.583-595. (10.1007/978-1-0716-1924-7_36)
- Menendez-Gonzalez, J. B. and Rodrigues, N. P. 2022. Exploring the associations between clonal hematopoiesis of indeterminate potential, myeloid malignancy, and atherosclerosis. In: Ramji, D. ed. Atherosclerosis. Vol. 2419, Methods in Molecular Biology Springer. , pp.73-88. (10.1007/978-1-0716-1924-7_5)
2021
- Lawson, H. et al., 2021. CITED2 coordinates key haematopoietic regulatory pathways to maintain the HSC pool in both steady-state haematopoiesis and transplantation. Stem Cell Reports 16 (11), pp.2784-2797. (10.1016/j.stemcr.2021.10.001)
- Abdelfattah, A. M. et al., 2021. Gata2 haploinsufficiency promotes proliferation and functional decline of HSCs with myeloid bias during aging. Blood Advances 5 (20), pp.4285-4290. (10.1182/bloodadvances.2021004726)
- O'Morain, V. L. et al. 2021. The Lab4P consortium of probiotics attenuates atherosclerosis in LDL receptor deficient mice fed a high fat diet and causes plaque stabilization by inhibiting inflammation and several pro-atherogenic processes. Molecular Nutrition & Food Research 65 (17) 2100214. (10.1002/mnfr.202100214)
- Moss, J. W. E. et al. 2021. Protective effects of a unique combination of nutritionally active ingredients on risk factors and gene expression associated with atherosclerosis in C57BL/6J mice fed a high fat diet. Food and Function 12 (8), pp.3657-3671. (10.1039/D0FO02867C)
- Lawson, H. et al., 2021. JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. Blood Advances 5 (3), pp.889-899. (10.1182/bloodadvances.2020002702)
- Almotiri, A. et al. 2021. Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. Journal of Clinical Investigation 131 (1) e129115. (10.1172/JCI129115)
2019
- Menendez Gonzalez, J. B. et al. 2019. Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells. Scientific Reports 9 12212. (10.1038/s41598-019-48589-0)
- Menendez Gonzalez, J. B. et al. 2019. Gata2 as a crucial regulator of stem cells in adult hematopoiesis and acute myeloid leukemia. Stem Cell Reports 13 (2), pp.291-306. (10.1016/j.stemcr.2019.07.005)
- Menendez-Gonzalez, J. B. et al., 2019. Isolation of murine hematopoietic stem cells. In: Boyd, A. S. ed. Immunological Tolerance: Methods and Protocols. Vol. 1899, Methods in Molecular Biology New York: Humana Press. , pp.15-23. (10.1007/978-1-4939-8938-6_2)
2018
- Boyd, A. S. and Rodrigues, N. P. 2018. Stem cells cycle toward immune surveillance. Immunity 48 (2), pp.187-190. (10.1016/j.immuni.2018.02.006)
2017
- Portero Migueles, R. et al., 2017. Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny. Developmental Biology 424 (2), pp.236-245. (10.1016/j.ydbio.2016.12.021)
- Guitart, A. V. et al., 2017. Fumarate hydratase is a critical regulator of hematopoietic stem cell functions. Journal of Experimental Medicine 214 (3), pp.-. 719. (10.1084/jem.20161087)
2013
- Rodrigues, N. and Tipping, A. J. 2013. Transcription factor GATA-2 regulates quiescence of hematopoietic stem and progenitor cells. In: Hayat, M. A. ed. Tumor Dormancy, Quiescence, and Senescence, Volume 2. Vol. 2, Springer. , pp.277-288. (10.1007/978-94-007-7726-2_26)
- Guha, P. et al., 2013. Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells. Cell Stem Cell 12 (4), pp.407-412. (10.1016/j.stem.2013.01.006)
2012
- Boyd, A. S. et al., 2012. Concise review: Immune recognition of induced pluripotent stem cells. Stem Cells 30 (5), pp.797-803. (10.1002/stem.1066)
- Rodrigues, N. et al. 2012. GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia. The International Journal of Biochemistry & Cell Biology 44 (3), pp.457-460. (10.1016/j.biocel.2011.12.004)
2009
- Kranc, K. R. et al., 2009. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell 5 (6), pp.659-665. (10.1016/j.stem.2009.11.001)
- Tipping, A. J. et al., 2009. High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood 113 (12), pp.2661-2672. (10.1182/blood-2008-06-161117)
2008
- Rodrigues, N. et al. 2008. GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood 112 (13), pp.4862-4873. (10.1182/blood-2008-01-136564)
2007
- Nijnik, A. et al., 2007. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447 (7145), pp.686-690. (10.1038/nature05875)
2005
- Craiu, A. et al., 2005. Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function. Blood 105 (5), pp.2235-2238. (10.1182/blood-2003-12-4399)
- Rodrigues, N. et al. 2005. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood 106 (2), pp.477-484. (10.1182/blood-2004-08-2989)
2004
- Qiu, J. et al., 2004. Regenerative response in ischemic brain restricted by p21cip1/waf1. Journal of Experimental Medicine 199 (7), pp.937-945. (10.1084/jem.20031385)
2002
- Adams, G. B. et al., 2002. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood 101 (1), pp.45-51. (10.1182/blood-2002-02-0486)
2001
- Cheng, T. et al., 2001. Transforming growth factor β1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21Cip1/Waf1or p27Kip1. Blood 98 (13), pp.3643-3649. (10.1182/blood.V98.13.3643)
2000
- Cheng, T. et al., 2000. Stem cell repopulation efficiency but not pool size is governed by p27 (kip1). Nature Medicine 6 , pp.1235-1240. (10.1038/81335)
- Cheng, T. et al., 2000. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287 (5459), pp.1804-1808. (10.1126/science.287.5459.1804)
Adrannau llyfrau
- Almotiri, A. , Abdelfattah, A. and Rodrigues, N. P. 2022. Flow cytometry analysis of hematopoietic stem/progenitor cells and mature blood cell subsets in atherosclerosis. In: Ramji, D. ed. Atherosclerosis. Vol. 2419, Methods in Molecular Biology Springer. , pp.583-595. (10.1007/978-1-0716-1924-7_36)
- Menendez-Gonzalez, J. B. and Rodrigues, N. P. 2022. Exploring the associations between clonal hematopoiesis of indeterminate potential, myeloid malignancy, and atherosclerosis. In: Ramji, D. ed. Atherosclerosis. Vol. 2419, Methods in Molecular Biology Springer. , pp.73-88. (10.1007/978-1-0716-1924-7_5)
- Menendez-Gonzalez, J. B. et al., 2019. Isolation of murine hematopoietic stem cells. In: Boyd, A. S. ed. Immunological Tolerance: Methods and Protocols. Vol. 1899, Methods in Molecular Biology New York: Humana Press. , pp.15-23. (10.1007/978-1-4939-8938-6_2)
- Rodrigues, N. and Tipping, A. J. 2013. Transcription factor GATA-2 regulates quiescence of hematopoietic stem and progenitor cells. In: Hayat, M. A. ed. Tumor Dormancy, Quiescence, and Senescence, Volume 2. Vol. 2, Springer. , pp.277-288. (10.1007/978-94-007-7726-2_26)
Erthyglau
- Abdelfattah, A. et al. 2026. Worldwide prevalence of Helicobacter pylori in patients with Mucosa-associated lymphoid tissue (MALT) lymphomas: A systematic review and meta-analysis. Acta Biomedica 97 (1) 17906. (10.23750/abm.2026.17906)
- Derrac Soria, A. et al. 2026. IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis. null (10.1101/2024.09.03.610972)
- Abdelfattah, A. et al. 2025. Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency. Stem Cell Reports 20 (8) 102596. (10.1016/j.stemcr.2025.102596)
- Almotiri, A. et al. 2025. Treating genetic blood disorders in the era of CRISPR-mediated genome editing. Molecular Therapy 33 (6), pp.2645-2662. (10.1016/j.ymthe.2025.01.031)
- Almotiri, A. et al. 2024. Zeb1 maintains long-term adult hematopoietic stem cell function and extramedullary hematopoiesis. Experimental Hematology 134 104177. (10.1016/j.exphem.2024.104177)
- Almotiri, A. , Boyd, A. S. and Rodrigues, N. P. 2023. Zeb1 Regulates the function of lympho-myeloid primed progenitors after transplantation. Biomolecules 13 (9) 1386. (10.3390/biom13091386)
- Chan, Y. et al. 2023. (+)-catechin attenuates multiple atherosclerosis-associated processes in vitro, modulates disease-associated risk factors in C57BL/6J mice and reduces atherogenesis in LDL receptor deficient mice by inhibiting inflammation and increasing markers of plaque stability. Molecular Nutrition & Food Research 67 (14) 2200716. (10.1002/mnfr.202200716)
- Rastogi, N. et al. 2023. Nuclear factor I-C overexpression promotes monocytic development and cell survival in acute myeloid leukemia. Leukemia 37 , pp.276-287. (10.1038/s41375-022-01801-z)
- Menendez-Gonzalez, J. B. et al., 2022. Ligand-based discovery of a novel GATA2 inhibitor targeting acute myeloid leukemia cells. Frontiers In Drug Discovery 2 1013229. (10.3389/fddsv.2022.1013229)
- Lawson, H. et al., 2021. CITED2 coordinates key haematopoietic regulatory pathways to maintain the HSC pool in both steady-state haematopoiesis and transplantation. Stem Cell Reports 16 (11), pp.2784-2797. (10.1016/j.stemcr.2021.10.001)
- Abdelfattah, A. M. et al., 2021. Gata2 haploinsufficiency promotes proliferation and functional decline of HSCs with myeloid bias during aging. Blood Advances 5 (20), pp.4285-4290. (10.1182/bloodadvances.2021004726)
- O'Morain, V. L. et al. 2021. The Lab4P consortium of probiotics attenuates atherosclerosis in LDL receptor deficient mice fed a high fat diet and causes plaque stabilization by inhibiting inflammation and several pro-atherogenic processes. Molecular Nutrition & Food Research 65 (17) 2100214. (10.1002/mnfr.202100214)
- Moss, J. W. E. et al. 2021. Protective effects of a unique combination of nutritionally active ingredients on risk factors and gene expression associated with atherosclerosis in C57BL/6J mice fed a high fat diet. Food and Function 12 (8), pp.3657-3671. (10.1039/D0FO02867C)
- Lawson, H. et al., 2021. JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. Blood Advances 5 (3), pp.889-899. (10.1182/bloodadvances.2020002702)
- Almotiri, A. et al. 2021. Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. Journal of Clinical Investigation 131 (1) e129115. (10.1172/JCI129115)
- Menendez Gonzalez, J. B. et al. 2019. Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells. Scientific Reports 9 12212. (10.1038/s41598-019-48589-0)
- Menendez Gonzalez, J. B. et al. 2019. Gata2 as a crucial regulator of stem cells in adult hematopoiesis and acute myeloid leukemia. Stem Cell Reports 13 (2), pp.291-306. (10.1016/j.stemcr.2019.07.005)
- Boyd, A. S. and Rodrigues, N. P. 2018. Stem cells cycle toward immune surveillance. Immunity 48 (2), pp.187-190. (10.1016/j.immuni.2018.02.006)
- Portero Migueles, R. et al., 2017. Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny. Developmental Biology 424 (2), pp.236-245. (10.1016/j.ydbio.2016.12.021)
- Guitart, A. V. et al., 2017. Fumarate hydratase is a critical regulator of hematopoietic stem cell functions. Journal of Experimental Medicine 214 (3), pp.-. 719. (10.1084/jem.20161087)
- Guha, P. et al., 2013. Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells. Cell Stem Cell 12 (4), pp.407-412. (10.1016/j.stem.2013.01.006)
- Boyd, A. S. et al., 2012. Concise review: Immune recognition of induced pluripotent stem cells. Stem Cells 30 (5), pp.797-803. (10.1002/stem.1066)
- Rodrigues, N. et al. 2012. GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia. The International Journal of Biochemistry & Cell Biology 44 (3), pp.457-460. (10.1016/j.biocel.2011.12.004)
- Kranc, K. R. et al., 2009. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell 5 (6), pp.659-665. (10.1016/j.stem.2009.11.001)
- Tipping, A. J. et al., 2009. High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood 113 (12), pp.2661-2672. (10.1182/blood-2008-06-161117)
- Rodrigues, N. et al. 2008. GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood 112 (13), pp.4862-4873. (10.1182/blood-2008-01-136564)
- Nijnik, A. et al., 2007. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447 (7145), pp.686-690. (10.1038/nature05875)
- Craiu, A. et al., 2005. Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function. Blood 105 (5), pp.2235-2238. (10.1182/blood-2003-12-4399)
- Rodrigues, N. et al. 2005. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood 106 (2), pp.477-484. (10.1182/blood-2004-08-2989)
- Qiu, J. et al., 2004. Regenerative response in ischemic brain restricted by p21cip1/waf1. Journal of Experimental Medicine 199 (7), pp.937-945. (10.1084/jem.20031385)
- Adams, G. B. et al., 2002. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood 101 (1), pp.45-51. (10.1182/blood-2002-02-0486)
- Cheng, T. et al., 2001. Transforming growth factor β1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21Cip1/Waf1or p27Kip1. Blood 98 (13), pp.3643-3649. (10.1182/blood.V98.13.3643)
- Cheng, T. et al., 2000. Stem cell repopulation efficiency but not pool size is governed by p27 (kip1). Nature Medicine 6 , pp.1235-1240. (10.1038/81335)
- Cheng, T. et al., 2000. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287 (5459), pp.1804-1808. (10.1126/science.287.5459.1804)
Bywgraffiad
Mae gan Dr. Rodrigues ddiddordeb hirsefydlog mewn bioleg bôn-gelloedd, gyda diddordeb arbennig yn y system haematopoietig. Hyfforddodd yn labordy yr Athro David Scadden yn Ysgol Feddygol Harvard i ddechrau ac aeth ymlaen i gael D.Phil mewn Meddygaeth Glinigol o Goleg Gwyrdd, Prifysgol Rhydychen dan oruchwyliaeth ar y cyd yr Athro Scadden, Paresh Vyas a Tariq Enver. Yn dilyn sawl blwyddyn o addysgu yn Rhydychen a hyfforddiant ymchwil ôl-ddoethurol yn labordy Enver, sefydlodd ei labordy a ariennir gan NIH yn Ysgol Meddygaeth Prifysgol Boston lle bu hefyd yn Athro Cynorthwyol. Ym mis Medi 2013, recriwtiwyd Dr Rodrigues i ailsefydlu ei labordy yn Sefydliad Bôn-gelloedd Canser Ewrop. Mae ganddo Ddarllenydd ym Mhrifysgol Caerdydd.
Contact Details
[email protected]
+44 29206 88507
Adeilad Hadyn Ellis, Ystafell Sefydliad Ymchwil Bôn-gelloedd Canser Ewropeaidd, Ysgol y Biowyddorau Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ
+44 29206 88507
Adeilad Hadyn Ellis, Ystafell Sefydliad Ymchwil Bôn-gelloedd Canser Ewropeaidd, Ysgol y Biowyddorau Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ
Themâu ymchwil
Arbenigeddau
- Celloedd bonyn
- Haematoleg
- Tiwmorau haematolegol