Yr Athro Andrew Sewell

2024

• Schwartz, J. C., Farrell, C. P., Freimanis, G., Sewell, A. K., Phillips, J. D. and Hammond, J. A. 2024. A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variation.. Immunogenetics 76, pp. 361-380. (10.1007/s00251-024-01355-7)
• Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134(18), article number: e164535. (10.1172/JCI164535)
• Ferrari, M. et al. 2024. Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies. Nature Communications 15(1), article number: 1583. (10.1038/s41467-024-45854-3)

2023

• Chen, Y. et al. 2023. Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity. Cell Reports 42(8), article number: 112827. (10.1016/j.celrep.2023.112827)
• Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186(16), pp. 3333-3349., article number: E27. (10.1016/j.cell.2023.06.020)

2022

• Goncharov, M. et al. 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19(9), pp. 1017–1019. (10.1038/s41592-022-01578-0)
• Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
• Martini, V. et al. 2022. Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells. Mucosal Immunology 15(3), pp. 428–442. (10.1038/s41385-021-00478-4)

2021

• Clement, M. et al. 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118(29), article number: e2019639118. (10.1073/pnas.2019639118)
• Crowther, M. D. and Sewell, A. K. 2021. The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease. Current Opinion in Immunology 69, pp. 10-17. (10.1016/j.coi.2020.12.002)
• Edmans, M. et al. 2021. Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in inbred Babraham pigs and outbred pigs. Frontiers in Immunology 11, article number: 604913. (10.3389/fimmu.2020.604913)
• Martini, V. et al. 2021. Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective local T cell and systemic antibody immune responses in pigs. Journal of Immunology 206(2), article number: ji2001086. (10.4049/jimmunol.2001086)

2020

• Hopkins, J. R. et al. 2020. Peptide cargo tunes a network of correlated motions in human leukocyte antigens. FEBS Journal 287(17), pp. 3777-3793. (10.1111/febs.15278)
• Attaf, M. et al. 2020. Cytomegalovirus-mediated T cell receptor repertoire perturbation is present in early life. Frontiers in Immunology 11, article number: 1587. (10.3389/fimmu.2020.01587)
• Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32(2), article number: 107885. (10.1016/j.celrep.2020.107885)
• Tarbe, M., Miles, J. J., Edwards, E. S. J., Sewell, A. K., Baker, B. M. and Quideau, S. 2020. Synthesis and biological evaluation of hapten-clicked analogues of the antigenic peptide Melan‐A/MART‐126(27L)‐35. ChemMedChem 15(9), pp. 799-807. (10.1002/cmdc.202000038)
• Yeo, L. et al. 2020. Circulating β cell‐specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. Clinical and Experimental Immunology 199(3), pp. 263-277. (10.1111/cei.13391)
• Crowther, M. D. et al. 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21, pp. 178 - 185. (10.1038/s41590-019-0578-8)
• Whalley, T. et al. 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11, article number: 296. (10.3389/fimmu.2020.00296)
• Bagaev, D. V. et al. 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48(D1), pp. D1057-D1062., article number: gkz874. (10.1093/nar/gkz874)

2019

• MacLachlan, B. J. et al. 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294(52), pp. 20246-20258. (10.1074/jbc.RA119.009437)
• Kim, A. et al. 2019. LILRB1 blockade enhances bispecific T cell engager antibody-induced tumor cell killing by effector CD8+ T cells. Journal of Immunology 203(4), pp. 1076-1087. (10.4049/jimmunol.1801472)
• Madura, F. et al. 2019. TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology 49(7), pp. 1052-1066. (10.1002/eji.201948085)
• Galloway, S. A. E. et al. 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10, article number: 319. (10.3389/fimmu.2019.00319)

2018

• Attaf, M. et al. 2018. Major TCR repertoire perturbation by immunodominant HLA-B*44:03 - restricted CMV - specific T cells. Frontiers in Immunology, article number: 2539. (10.3389/fimmu.2018.02539)
• Sewell, A. K. and Legut, M. 2018. Designer T-cells and T-cell receptors for customised cancer immunotherapies. Current Opinion in Pharmacology 41, pp. 96-103. (10.1016/j.coph.2018.05.005)
• Yeo, L. et al. 2018. Autoreactive T effector memory differentiation mirrors b cell function in type 1 diabetes. Journal of Clinical Investigation 128(8), pp. 3460-3474. (10.1172/JCI120555)
• Zhao, X. et al. 2018. Nonstimulatory peptide?MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9, article number: 2716. (10.1038/s41467-018-05288-0)
• Dolton, G. et al. 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9, article number: 1378. (10.3389/fimmu.2018.01378)
• Tungatt, K. et al. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14(5), article number: e1007017. (10.1371/journal.ppat.1007017)
• Holland, C. J. et al. 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9, article number: 674. (10.3389/fimmu.2018.00674)
• Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128(4), pp. 1569-1580. (10.1172/JCI91512)
• Rius, C. et al. 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations. Journal of Immunology 200(7), pp. 2263-2279. (10.4049/jimmunol.1700242)
• Bovay, A. et al. 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48(2), pp. 258-272. (10.1002/eji.201747082)
• Legut, M., Dolton, G., Mian, A., Ottmann, O. and Sewell, A. 2018. CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells. Blood 131(3), pp. 311-322. (10.1182/blood-2017-05-787598)
• Shugay, M. et al. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46(D1), pp. D419-D427. (10.1093/nar/gkx760)

2017

• Maciocia, P. M. et al. 2017. Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies. Nature Medicine 23, pp. 1416-1423. (10.1038/nm.4444)
• Cole, D. K. et al. 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8, article number: 1503. (10.3389/fimmu.2017.01503)
• Jones, N. et al. 2017. Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation. Frontiers in Immunology 8, article number: 1516. (10.3389/fimmu.2017.01516)
• Donia, M. et al. 2017. PD-1+ polyfunctional T cells dominate the periphery after tumour-infiltrating lymphocyte therapy for cancer. Clinical Cancer Research 23(19), pp. 5779-5788. (10.1158/1078-0432.CCR-16-1692)
• Fuller, A. et al. 2017. Thermal stability of heterotrimeric pMHC proteins as determined by circular dichroism spectroscopy. Bio-protocol 7(13), pp. -., article number: e2366. (10.21769/BioProtoc.2366)
• MacLachlan, B. J. et al. 2017. Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens. Journal of Visualized Experiments(120), article number: e54991. (10.3791/54991)
• Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292(3), pp. 802-813. (10.1074/jbc.M116.741603)
• Tan, M. et al. 2017. HLA class I-redirected anti-tumour CD4+T-cells require a higher TCR binding affinity for optimal activity than CD8+T-cells. Clinical and Experimental Immunology 187(1), pp. 124-137. (10.1111/cei.12828)

2016

• Attaf, M. and Sewell, A. K. 2016. Disease etiology and diagnosis by TCR repertoire analysis goes viral. European Journal of Immunology 46(11), pp. 2516-2519. (10.1002/eji.201646649)
• Pageon, S. V. et al. 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113(37), pp. E5454-E5463. (10.1073/pnas.1607436113)
• Hanson, W. M., Chen, Z., Jackson, L. K., Attaf, M., Sewell, A. K., Heemstra, J. M. and Phillips, J. D. 2016. Reversible oligonucleotide chain blocking enables bead capture and amplification of T-Cell receptor alpha and beta chain mRNAs. Journal of the American Chemical Society 138(35), pp. 11073-11076. (10.1021/jacs.6b04465)
• Stadinski, B. D. et al. 2016. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nature Immunology 17, pp. 946-955. (10.1038/ni.3491)
• Laugel, B. et al. 2016. Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology 197(3), pp. 971-982. (10.4049/jimmunol.1501402)
• Meermeier, E. W. et al. 2016. Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens. Nature Communications 7, article number: 12506. (10.1038/ncomms12506)
• Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94(6), pp. 573-582. (10.1038/icb.2016.12)
• Caucheteux, S. M. et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136(6), pp. 1172-1181. (10.1016/j.jid.2016.01.033)
• Cole, D. K. et al. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126(6), pp. 2191-2204. (10.1172/JCI85679)
• Bianchi, V. et al. 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291(17), pp. 8951-8959. (10.1074/jbc.M115.707414)
• Theaker, S. M. et al. 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430, pp. 43-50. (10.1016/j.jim.2016.01.014)
• Tsai, M. et al. 2016. Paediatric non-progression following grandmother-to-child HIV transmission. Retrovirology 13(1), pp. 65. (10.1186/s12977-016-0300-y)

2015

• Holland, C. J. et al. 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195(12), pp. 5827-5836. (10.4049/jimmunol.1402787)
• Dolton, G. M. et al. 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146(1), pp. 11-22. (10.1111/imm.12499)
• Neller, M. A. et al. 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93, pp. 625-633. (10.1038/icb.2015.17)
• Motozono, C. et al. 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290(31), pp. 18924-18933. (10.1074/jbc.M114.622522)
• Attaf, M., Legut, M., Cole, D. and Sewell, A. K. 2015. The T cell antigen receptor: the Swiss army knife of the immune. Clinical and Experimental Immunology 181(1), pp. 1-18. (10.1111/cei.12622)
• Motozono, C., Bridgeman, J. S., Price, D., Sewell, A. K. and Ueno, T. 2015. Clonotypically similar hybrid ab T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity. Clinical and Experimental Immunology 180(3), pp. 560-570. (10.1111/cei.12610)
• Gilham, D. E. et al. 2015. Adoptive t-cell therapy for cancer in the United Kingdom: a review of activity for the British Society of Gene and Cell Therapy Annual Meeting 2015. Human Gene Therapy 26(5), pp. 276-285. (10.1089/hum.2015.024)
• Skowera, A. et al. 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64(3), pp. 916-925. (10.2337/db14-0332)
• Madura, F. et al. 2015. Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides. European Journal of Immunology 45(2), pp. 584-591. (10.1002/eji.201445114)
• Straetemans, T. et al. 2015. Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment. Molecular Therapy 23(2), pp. 396-406. (10.1038/mt.2014.215)
• Tungatt, K. et al. 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194(1), pp. 463-474. (10.4049/jimmunol.1401785)
• Knight, R. R. et al. 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179(1), pp. 100-107. (10.1111/cei.12436)
• Attaf, M., Huseby, E. and Sewell, A. K. 2015. αβ T cell receptors as predictors of health and disease. Cellular and Molecular Immunology 12, pp. 391-399. (10.1038/cmi.2014.134)
• Legut, M., Cole, D. and Sewell, A. K. 2015. The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy. Cellular and Molecular Immunology 12, pp. 656-668. (10.1038/cmi.2015.28)
• Kløverpris, H. N. et al. 2015. A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology 12(1), article number: 20. (10.1186/s12977-015-0149-5)

2014

• Tan, M. et al. 2014. T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells. Clinical and Experimental Immunology 180(2), pp. 255-270. (10.1111/cei.12570)
• Stepanek, O. et al. 2014. Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell 159(2), pp. 333-345. (10.1016/j.cell.2014.08.042)
• Dolton, G. M. et al. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177(1), pp. 47-63. (10.1111/cei.12339)
• Motozono, C. et al. 2014. Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. The Journal of Immunology 192(7), pp. 3428-3434. (10.4049/jimmunol.1302667)
• Bhati, M., Cole, D., McCluskey, J., Sewell, A. K. and Rossjohn, J. 2014. The versatility of the αβ T-cell antigen receptor. Protein Science 23(3), pp. 260-272. (10.1002/pro.2412)

2013

• van den Berg, H. A. et al. 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4, article number: 250. (10.3389/fimmu.2013.00250)
• Madura, F. et al. 2013. T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry 288(26), pp. 18766-18775. (10.1074/jbc.M113.464560)
• Pentier, J. M., Sewell, A. K. and Miles, J. J. 2013. Advances in T-Cell Epitope Engineering. Frontiers in Immunology 4, article number: 133. (10.3389/fimmu.2013.00133)
• Motozono, C. et al. 2013. CD8+ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS ONE 8(6), article number: e66152. (10.1371/journal.pone.0066152)
• Challier, J., Bruniquel, D., Sewell, A. K. and Laugel, B. 2013. Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity. Immunology 138(4), pp. 402-410. (10.1111/imm.12053)
• Xu, W. et al. 2013. The nucleocapsid protein of rift valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses. PLoS ONE 8(3), article number: e59210. (10.1371/journal.pone.0059210)
• Welton, J. et al. 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28(3), pp. 464-471. (10.1002/jbmr.1797)
• Eukeruche-Makinde, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
• Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
• Cole, D. et al. 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289(2), pp. 628-638. (10.1074/jbc.M113.522110)
• Knight, R. R. et al. 2013. Human β-cell killing by autoreactive preproinsulin-specific cd8 t cells is predominantly granule-mediated with the potency dependent upon t-cell receptor avidity. Diabetes 62(1), pp. 205-213. (10.2337/db12-0315)

2012

• Matthews, P. C. et al. 2012. Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single gag epitope. Journal of Virology 86(23), pp. 12643-12654. (10.1128/JVI.01381-12)
• Ekeruche, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
• Ekeruche-Makinde, J. et al. 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287(44), pp. 37269-37281. (10.1074/jbc.M112.386409)
• Cole, D. K., Laugel, B., Clement, M., Price, D. A., Wooldridge, L. and Sewell, A. K. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137(2), pp. 139-148. (10.1111/j.1365-2567.2012.03625.x)
• Holland, C. J. et al. 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2, article number: 629. (10.1038/srep00629)
• Sewell, A. K. 2012. Why must T cells be cross-reactive?. Nature Reviews Immunology 12(9), pp. 669-677. (10.1038/nri3279)
• Bulek, A. M. et al. 2012. TCR/pMHC optimized protein crystallization screen. Journal of Immunological Methods 382(1-2), pp. 203-210. (10.1016/j.jim.2012.06.007)
• Liddy, N. et al. 2012. Monoclonal TCR-redirected tumor cell killing. Nature Medicine 18(6), pp. 980-987. (10.1038/nm.2764)
• Bulek, A. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
• Bulek, A. M. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
• Cole, D. et al. 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3, article number: 665. (10.1038/ncomms1665)
• Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287(2), pp. 1168-1177. (10.1074/jbc.M111.289488)
• Bridgeman, J. S., Sewell, A. K., Miles, J. J., Price, D. A. and Cole, D. K. 2012. Structural and biophysical determinants of ab T-cell antigen recognition. Immunology 135(1), pp. 9-18. (10.1111/j.1365-2567.2011.03515.x)

2011

• Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187(2), pp. 654-663. (10.4049/jimmunol.1003941)
• Miles, K. M., Miles, J. J., Madura, F., Sewell, A. K. and Cole, D. 2011. Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. Molecular Immunology 48(4), pp. 728-732. (10.1016/j.molimm.2010.11.004)
• Laugel, B. F., Cole, D., Clement, M., Wooldridge, L., Price, D. and Sewell, A. K. 2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90(6), pp. 1089-1099. (10.1189/jlb.0611316)

2010

• Cole, D. et al. 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185(4), pp. 2600-2610. (10.4049/jimmunol.1000629)
• Wooldridge, L., Laugel, B. F., Ekeruche, J., Clement, M., van den Berg, H. A., Price, D. and Sewell, A. K. 2010. CD8 controls T cell cross-reactivity. The Journal of Immunology 185(8), pp. 4625-4632. (10.4049/jimmunol.1001480)
• Schaubert, K. L. et al. 2010. Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. European Journal of Immunology 40(7), pp. 1950-1962. (10.1002/eji.200940079)
• Wooldridge, L. et al. 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184(7), pp. 3357-3366. (10.4049/jimmunol.0902398)
• Chen, J. et al. 2010. Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor. The Journal of Immunology 184(4), pp. 1829-1839. (10.4049/jimmunol.0902103)
• Walker, L. J., Sewell, A. K. and Klenerman, P. 2010. T cell sensitivity and the outcome of viral infection. Clinical and Experimental Immunology 159(3), pp. 245-255. (10.1111/j.1365-2249.2009.04047.x)
• Miles, J. J. et al. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6(11), article number: e1001198. (10.1371/journal.ppat.1001198)

2009

• Borbulevych, O. Y. et al. 2009. T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity 31(6), pp. 885-896. (10.1016/j.immuni.2009.11.003)
• Hoffman, M. et al. 2009. Novel tetramer technology for the detection of high affinity CD8 T cells [Conference poster abstract]. Retrovirology 6(S3), article number: P409. (10.1186/1742-4690-6-S3-P409)
• Lissina, A. et al. 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340(1), pp. 11-24. (10.1016/j.jim.2008.09.014)
• Jo, J. et al. 2009. Analysis of CD8+ T-Cell-Mediated Inhibition of Hepatitis C Virus Replication Using a Novel Immunological Model. Gastroenterology 136(4), pp. 1391-1401. (10.1053/j.gastro.2008.12.034)
• Cole, D. et al. 2009. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry 284(40), article number: 27281-27289. (10.1074/jbc.M109.022509)
• Choudhuri, K. et al. 2009. Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation. Journal of Biological Chemistry 284(38), pp. 26096-26105. (10.1074/jbc.M109.039966)
• Horlock, C. et al. 2009. ELISPOT and functional T cell analyses using HLA mono-specific target cells. Journal of Immunological Methods 350(1-2), pp. 150-160. (10.1016/j.jim.2009.08.011)
• Wooldridge, L., Lissina, A., Cole, D., van den Berg, H. A., Price, D. and Sewell, A. K. 2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126(2), pp. 147-164. (10.1111/j.1365-2567.2008.02848.x)

2008

• Varela-Rohena, A. et al. 2008. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nature Medicine 14(12), pp. 1390-1395. (10.1038/nm.1779)
• Skowera, A. et al. 2008. CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. Journal of Clinical Investigation 118(10), pp. 3390-3402. (10.1172/JCI35449)
• Melenhorst, J. J. et al. 2008. Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of Immunological Methods 338(1-2), pp. 31-39. (10.1016/j.jim.2008.07.008)
• Cole, D., Dunn, S. M., Sami, M., Boulter, J. M., Jakobsen, B. K. and Sewell, A. K. 2008. T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding. Molecular Immunology 45(9), pp. 2700-2709. (10.1016/j.molimm.2007.12.009)
• Weichsel, R. et al. 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Research 14(8), pp. 2484-2491. (10.1158/1078-0432.CCR-07-4393)
• Chattopadhyay, P. K. et al. 2008. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+T cells with peptide-major histocompatibility complex class I tetramers. Cytometry Part A 73A(11), pp. 1001-1009. (10.1002/cyto.a.20642)
• Scriba, T. J., Sierro, S., Brown, E. L., Phillips, R. E., Sewell, A. K. and Massey, R. C. 2008. The staphyloccous aureus eap protein activates expression of proinflammatory cytokines. Infection and Immunity 76(5), pp. 2164-2168. (10.1128/IAI.01699-07)
• Kasprowicz, V. et al. 2008. Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. Journal of Clinical Investigation 118(3), pp. 1143-1153. (10.1172/JCI33082)

2007

• Laugel, B. F. et al. 2007. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotxic T lymphocyte activation and tetramer properties. The Journal of Biological Chemistry 282(33), pp. 23799-22810. (10.1074/jbc.M700976200)
• Cole, D. et al. 2007. Human TCR-binding affinity is governed by MHC class restriction. The Journal of Immunology 178(9), pp. 5727-5734. (10.4049/​jimmunol.178.9.5727)
• Wooldridge, L. et al. 2007. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. European Journal of Immunology 37(5), pp. 1323-1333. (10.1002/eji.200636765)
• Gostick, E. et al. 2007. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. European Journal of Immunology 37(2), pp. 479-486. (10.1002/eji.200636243)
• Boulter, J. M., Schmitz, N., Sewell, A. K., Godkin, A. J., Bachmann, M. F. and Gallimore, A. M. 2007. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. European Journal of Immunology 37(3), pp. 798-806. (10.1002/eji.200636743)
• Yuan, F. et al. 2007. Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 63(9), pp. 758-760. (10.1107/S1744309107037244)
• Schaubert, K. L. et al. 2007. Availability of a diversely Avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 gag p2419-27 epitope. The Journal of Immunology 178(12), pp. 7756-7766. (10.4049/jimmunol.178.12.7756)
• Laugel, B., Price, D., Milicic, A. and Sewell, A. K. 2007. CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. European Journal of Immunology 37(4), pp. 905-913. (10.1002/eji.200636718)

2006

• Wooldridge, L. et al. 2006. Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. European Journal of Immunology 36(7), pp. 1847-1855. (10.1002/eji.200635886)
• Laugel, B., Price, D. and Sewell, A. K. 2006. On the path to TCR-directed therapeutics. Nature Biotechnology 24(6), pp. 615-616. (10.1038/nbt0606-615b)

2005

• Price, D. et al. 2005. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. Journal of Experimental Medicine 202(10), pp. 1349-61. (10.1084/jem.20051357)
• Wooldridge, L. et al. 2005. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. The Journal of Biological Chemistry 280(30), pp. 27491-27501. (10.1074/jbc.M500555200)
• Sewell, A., Philips, R., Walker, B. and Goulder, P. 2005. Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. Journal of Experimental Medicine 201(6), pp. 891-902. (10.1084/jem.20041455)
• Laugel, B. et al. 2005. Design of soluble recombinant T Cell receptors for antigen targeting and T cell inhibition. Journal of Biological Chemistry 280(3), pp. 1882-1892. (10.1074/jbc.M409427200)
• Rezvani, K. et al. 2005. T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization.. Clinical Cancer Research 11(24), pp. 8799-8807. (10.1158/1078-0432.CCR-05-1314)
• Hewitt, R. E., Lissina, A., Green, A. E., Slay, E. S., Price, D. and Sewell, A. K. 2005. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clinical and Experimental Immunology 139(1), pp. 101-111. (10.1111/j.1365-2249.2005.02665.x)

2004

• Green, A. E. et al. 2004. Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin. Clinical & Experimental Immunology 136(3), pp. 472-482. (10.1111/j.1365-2249.2004.02472.x)

2003

• Wooldridge, L. et al. 2003. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J Immunol 171, pp. 6650-60.

2002

• Glick, M. et al. 2002. Novel CD8+ T cell antagonists based on 2-Microglobulin. Journal of Biological Chemistry 277(23), pp. 20840-20846. (10.1074/jbc.M201819200)
• Kelleher, A. D., Sewell, A. K. and Price, D. 2002. Dyslipidemia due to retroviral protease inhibitors [Letter]. Nature Medicine 8(4), pp. 308. (10.1038/nm0402-308a)

2001

• Sewell, A. K., McMichael, A. J., Screaton, G. R. and Cerundolo, V. 2001. A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity 14(5), pp. 591-602. (10.1016/S1074-7613(01)00133-9)
• Oxenius, A., Price, D., Dawson, S. J., Tun, T., Easterbrook, P. J., Phillips, R. E. and Sewell, A. K. 2001. Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens. AIDS 15(1), pp. 121-122. (10.1097/00002030-200101050-00018)
• Purbhoo, M. A. et al. 2001. The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor chain. Journal of Biological Chemistry 276(35), pp. 32786-32792. (10.1074/jbc.M102498200)
• Sewell, A. K. and Price, D. 2001. Dendritic cells and transmission of HIV-1. Trends in Immunology 22(4), pp. 173-175. (10.1016/S1471-4906(01)01866-X)

2000

• Oxenius, A. et al. 2000. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 97(7), pp. 3382-3387. (10.1073/pnas.97.7.3382)

1999

• Price, D., Klenerman, P., Booth, B. L., Phillips, R. E. and Sewell, A. K. 1999. Cytotoxic T lymphocytes, chemokines and antiviral immunity. Immunology Today 20(5), pp. 212-216. (10.1016/S0167-5699(99)01447-4)
• Sewell, A. K. et al. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5, pp. 399-404. (10.1038/7398)

1998

• Lewis, J. W., Sewell, A. K., Price, D. and Elliot, T. 1998. HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. European Journal of Immunology 28, pp. 3214-3220.
• Price, D., Sewell, A. K., Dong, T., Tan, R., Goulder, P. J. R., Rowland-Jones, S. L. and Phillips, R. E. 1998. Antigen-specific release of b-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Current Biology 8(6), pp. 355-358. (10.1016/S0960-9822(98)70138-1)

1997

• Sewell, A. K., Harcourt, G. C., Goulder, P. J. R., Price, D. and Phillips, R. E. 1997. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. European Journal of Immunology 27(9), pp. 2323-2329. (10.1002/eji.1830270929)
• Price, D. et al. 1997. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proceedings of the National Academy of Sciences 94(5), pp. 1890-1895. (10.1073/pnas.94.5.1890)