Yr Athro Andrew Sewell

2026

• Caillaud, M. E. et al. 2026. Optimised procurement of cancer-reactive T-cell receptors from clinical samples. Immunotherapy Advances 6 (1) ltag009. (10.1093/immadv/ltag009)
• Goto, Y. et al., 2026. A probiotic bacterium modulates antitumour γδ T-cell responses in lung cancer. Frontiers in Immunology 17 1750569. (10.3389/fimmu.2026.1750569)
• Thomas, H. et al. 2026. Protocol for MR1-ligand cross-linking to discover metabolite antigens by proteomics. STAR Protocols 7 (1) 104399. (10.1016/j.xpro.2026.104399)
• Sewell, A. 2026. A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling. arXiv (10.64898/2026.02.19.706929)

2025

• Schmidlin, T. et al., 2025. MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens. Cell Reports Methods 101120. (10.1016/j.crmeth.2025.101120)
• Ferrari, M. et al., 2025. Reply to: Oligoclonality of TRBC1 and TRBC2 in T cell lymphomas as mechanism of primary resistance to TRBC-directed CAR T cell therapies. Nature Communications 16 (1) 1103. (10.1038/s41467-025-56396-7)
• Dolton, G. et al., 2025. MHC-related protein 1-restricted recognition of cancer via a semi-invariant TCR-α chain.. The Journal of Clinical Investigation 135 (1) e181895. (10.1172/JCI181895)

2024

• Schwartz, J. C. et al., 2024. A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variation.. Immunogenetics 76 , pp.361-380. (10.1007/s00251-024-01355-7)
• Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134 (18) e164535. (10.1172/JCI164535)
• Ferrari, M. et al., 2024. Structure-guided engineering of immunotherapies targeting TRBC1 and TRBC2 in T cell malignancies. Nature Communications 15 (1) 1583. (10.1038/s41467-024-45854-3)

2023

• Chen, Y. et al. 2023. Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity. Cell Reports 42 (8) 112827. (10.1016/j.celrep.2023.112827)
• Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186 (16), pp.3333-3349. E27. (10.1016/j.cell.2023.06.020)

2022

• Goncharov, M. et al., 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19 (9), pp.1017–1019. (10.1038/s41592-022-01578-0)
• Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185 (16), pp.2936-2951. (10.1016/j.cell.2022.07.002)
• Martini, V. et al., 2022. Spatial, temporal and molecular dynamics of swine influenza virus-specific CD8 tissue resident memory T cells. Mucosal Immunology 15 (3), pp.428–442. (10.1038/s41385-021-00478-4)

2021

• Clement, M. et al. 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118 (29) e2019639118. (10.1073/pnas.2019639118)
• Crowther, M. D. and Sewell, A. K. 2021. The burgeoning role of MR1-restricted T-cells in infection, cancer and autoimmune disease. Current Opinion in Immunology 69 , pp.10-17. (10.1016/j.coi.2020.12.002)
• Edmans, M. et al., 2021. Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in inbred Babraham pigs and outbred pigs. Frontiers in Immunology 11 604913. (10.3389/fimmu.2020.604913)
• Martini, V. et al., 2021. Simultaneous aerosol and intramuscular immunization with influenza vaccine induces powerful protective local T cell and systemic antibody immune responses in pigs. Journal of Immunology 206 (2) ji2001086. (10.4049/jimmunol.2001086)

2020

• Attaf, M. et al. 2020. Cytomegalovirus-mediated T cell receptor repertoire perturbation is present in early life. Frontiers in Immunology 11 1587. (10.3389/fimmu.2020.01587)
• Hopkins, J. R. et al. 2020. Peptide cargo tunes a network of correlated motions in human leukocyte antigens. FEBS Journal 287 (17), pp.3777-3793. (10.1111/febs.15278)
• Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) 107885. (10.1016/j.celrep.2020.107885)
• Tarbe, M. et al., 2020. Synthesis and biological evaluation of hapten-clicked analogues of the antigenic peptide Melan‐A/MART‐126(27L)‐35. ChemMedChem 15 (9), pp.799-807. (10.1002/cmdc.202000038)
• Yeo, L. et al., 2020. Circulating β cell‐specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes. Clinical and Experimental Immunology 199 (3), pp.263-277. (10.1111/cei.13391)
• Crowther, M. D. et al. 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21 , pp.178 - 185. (10.1038/s41590-019-0578-8)
• Whalley, T. et al. 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11 296. (10.3389/fimmu.2020.00296)
• Bagaev, D. V. et al., 2020. VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium. Nucleic Acids Research 48 (D1), pp.D1057-D1062. gkz874. (10.1093/nar/gkz874)

2019

• MacLachlan, B. J. et al., 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294 (52), pp.20246-20258. (10.1074/jbc.RA119.009437)
• Kim, A. et al., 2019. LILRB1 blockade enhances bispecific T cell engager antibody-induced tumor cell killing by effector CD8+ T cells. Journal of Immunology 203 (4), pp.1076-1087. (10.4049/jimmunol.1801472)
• Madura, F. et al. 2019. TCR-induced alteration of primary MHC peptide anchor residue. European Journal of Immunology 49 (7), pp.1052-1066. (10.1002/eji.201948085)
• Galloway, S. A. E. et al. 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10 319. (10.3389/fimmu.2019.00319)

2018

• Attaf, M. et al. 2018. Major TCR repertoire perturbation by immunodominant HLA-B*44:03 - restricted CMV - specific T cells. Frontiers in Immunology 2539. (10.3389/fimmu.2018.02539)
• Sewell, A. K. and Legut, M. 2018. Designer T-cells and T-cell receptors for customised cancer immunotherapies. Current Opinion in Pharmacology 41 , pp.96-103. (10.1016/j.coph.2018.05.005)
• Yeo, L. et al., 2018. Autoreactive T effector memory differentiation mirrors b cell function in type 1 diabetes. Journal of Clinical Investigation 128 (8), pp.3460-3474. (10.1172/JCI120555)
• Zhao, X. et al., 2018. Nonstimulatory peptide?MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature Communications 9 2716. (10.1038/s41467-018-05288-0)
• Dolton, G. et al. 2018. Optimized peptide-MHC multimer protocols for detection and isolation of autoimmune T-cells. Frontiers in Immunology 9 1378. (10.3389/fimmu.2018.01378)
• Tungatt, K. et al. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14 (5) e1007017. (10.1371/journal.ppat.1007017)
• Holland, C. J. et al. 2018. In silico and structural analyses demonstrate that intrinsic protein motions guide T cell receptor complementarity determining region loop flexibility. Frontiers in Immunology 9 674. (10.3389/fimmu.2018.00674)
• Miles, J. J. et al. 2018. Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry. Journal of Clinical Investigation 128 (4), pp.1569-1580. (10.1172/JCI91512)
• Rius, C. et al., 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations. Journal of Immunology 200 (7), pp.2263-2279. (10.4049/jimmunol.1700242)
• Bovay, A. et al., 2018. T cell receptor alpha variable 12-2 bias in the immunodominant response to Yellow fever virus. European Journal of Immunology 48 (2), pp.258-272. (10.1002/eji.201747082)
• Legut, M. et al. 2018. CRISPR-mediated TCR replacement generates superior anticancer transgenic T-cells. Blood 131 (3), pp.311-322. (10.1182/blood-2017-05-787598)
• Shugay, M. et al., 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46 (D1), pp.D419-D427. (10.1093/nar/gkx760)

2017

• Maciocia, P. M. et al., 2017. Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies. Nature Medicine 23 , pp.1416-1423. (10.1038/nm.4444)
• Cole, D. K. et al. 2017. Dual molecular mechanisms govern escape at immunodominant HLA A2-restricted HIV epitope. Frontiers in Immunology 8 1503. (10.3389/fimmu.2017.01503)
• Jones, N. et al., 2017. Metabolic adaptation of human CD4+ and CD8+ T-Cells to T-Cell receptor-mediated stimulation. Frontiers in Immunology 8 1516. (10.3389/fimmu.2017.01516)
• Donia, M. et al., 2017. PD-1+ polyfunctional T cells dominate the periphery after tumour-infiltrating lymphocyte therapy for cancer. Clinical Cancer Research 23 (19), pp.5779-5788. (10.1158/1078-0432.CCR-16-1692)
• Fuller, A. et al. 2017. Thermal stability of heterotrimeric pMHC proteins as determined by circular dichroism spectroscopy. Bio-protocol 7 (13), pp.-. e2366. (10.21769/BioProtoc.2366)
• MacLachlan, B. J. et al. 2017. Using X-ray crystallography, biophysics, and functional assays to determine the mechanisms governing T-cell receptor recognition of cancer antigens. Journal of Visualized Experiments (120) e54991. (10.3791/54991)
• Cole, D. K. et al. 2017. Structural mechanism underpinning cross-reactivity of a CD8+ T-cell clone that recognises a peptide derived from human telomerase reverse transcriptase. Journal of Biological Chemistry 292 (3), pp.802-813. (10.1074/jbc.M116.741603)
• Tan, M. et al., 2017. HLA class I-redirected anti-tumour CD4+T-cells require a higher TCR binding affinity for optimal activity than CD8+T-cells. Clinical and Experimental Immunology 187 (1), pp.124-137. (10.1111/cei.12828)

2016

• Pageon, S. V. et al., 2016. Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proceedings of the National Academy of Sciences 113 (37), pp.E5454-E5463. (10.1073/pnas.1607436113)
• Hanson, W. M. et al., 2016. Reversible oligonucleotide chain blocking enables bead capture and amplification of T-Cell receptor alpha and beta chain mRNAs. Journal of the American Chemical Society 138 (35), pp.11073-11076. (10.1021/jacs.6b04465)
• Stadinski, B. D. et al., 2016. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nature Immunology 17 , pp.946-955. (10.1038/ni.3491)
• Laugel, B. et al. 2016. Engineering of isogenic cells deficient for MR1 with a CRISPR/Cas9 lentiviral system: tools to study microbial antigen processing and presentation to human MR1-restricted T cells. Journal of Immunology 197 (3), pp.971-982. (10.4049/jimmunol.1501402)
• Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94 (6), pp.573-582. (10.1038/icb.2016.12)
• Caucheteux, S. M. et al. 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136 (6), pp.1172-1181. (10.1016/j.jid.2016.01.033)
• Cole, D. K. et al. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126 (6), pp.2191-2204. (10.1172/JCI85679)
• Bianchi, V. et al. 2016. A molecular switch abrogates glycoprotein 100 (gp100) T-cell Receptor (TCR) targeting of a human melanoma antigen. Journal of Biological Chemistry 291 (17), pp.8951-8959. (10.1074/jbc.M115.707414)
• Theaker, S. M. et al. 2016. T-cell libraries allow simple parallel generation of multiple peptide-specific human T-cell clones. Journal of Immunological Methods 430 , pp.43-50. (10.1016/j.jim.2016.01.014)
• Attaf, M. and Sewell, A. K. 2016. Disease etiology and diagnosis by TCR repertoire analysis goes viral. European Journal of Immunology 46 (11), pp.2516-2519. (10.1002/eji.201646649)
• Meermeier, E. W. et al., 2016. Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens. Nature Communications 7 12506. (10.1038/ncomms12506)
• Tsai, M. et al., 2016. Paediatric non-progression following grandmother-to-child HIV transmission. Retrovirology 13 (1), pp.65. (10.1186/s12977-016-0300-y)

2015

• Holland, C. J. et al., 2015. Enhanced detection of antigen-specific CD4+ T cells using altered peptide flanking residue peptide-MHC class II multimers. Journal of Immunology 195 (12), pp.5827-5836. (10.4049/jimmunol.1402787)
• Dolton, G. M. et al. 2015. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. Immunology 146 (1), pp.11-22. (10.1111/imm.12499)
• Motozono, C. et al. 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290 (31), pp.18924-18933. (10.1074/jbc.M114.622522)
• Gilham, D. E. et al., 2015. Adoptive t-cell therapy for cancer in the United Kingdom: a review of activity for the British Society of Gene and Cell Therapy Annual Meeting 2015. Human Gene Therapy 26 (5), pp.276-285. (10.1089/hum.2015.024)
• Skowera, A. et al., 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3), pp.916-925. (10.2337/db14-0332)
• Madura, F. et al., 2015. Structural basis for ineffective T-cell responses to MHC anchor residue-improved 'heteroclitic' peptides. European Journal of Immunology 45 (2), pp.584-591. (10.1002/eji.201445114)
• Tungatt, K. et al. 2015. Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs. Journal of Immunology 194 (1), pp.463-474. (10.4049/jimmunol.1401785)
• Attaf, M. , Huseby, E. and Sewell, A. K. 2015. αβ T cell receptors as predictors of health and disease. Cellular and Molecular Immunology 12 , pp.391-399. (10.1038/cmi.2014.134)
• Attaf, M. et al. 2015. The T cell antigen receptor: the Swiss army knife of the immune. Clinical and Experimental Immunology 181 (1), pp.1-18. (10.1111/cei.12622)
• Kløverpris, H. N. et al., 2015. A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology 12 (1) 20. (10.1186/s12977-015-0149-5)
• Knight, R. R. et al., 2015. A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells. Clinical and Experimental Immunology 179 (1), pp.100-107. (10.1111/cei.12436)
• Legut, M. , Cole, D. and Sewell, A. K. 2015. The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy. Cellular and Molecular Immunology 12 , pp.656-668. (10.1038/cmi.2015.28)
• Motozono, C. et al. 2015. Clonotypically similar hybrid ab T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity. Clinical and Experimental Immunology 180 (3), pp.560-570. (10.1111/cei.12610)
• Neller, M. A. et al., 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp.625-633. (10.1038/icb.2015.17)
• Straetemans, T. et al., 2015. Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment. Molecular Therapy 23 (2), pp.396-406. (10.1038/mt.2014.215)

2014

• Tan, M. et al. 2014. T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells. Clinical and Experimental Immunology 180 (2), pp.255-270. (10.1111/cei.12570)
• Stepanek, O. et al., 2014. Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell 159 (2), pp.333-345. (10.1016/j.cell.2014.08.042)
• Bhati, M. et al., 2014. The versatility of the αβ T-cell antigen receptor. Protein Science 23 (3), pp.260-272. (10.1002/pro.2412)
• Dolton, G. M. et al. 2014. Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells. Clinical and Experimental Immunology 177 (1), pp.47-63. (10.1111/cei.12339)
• Motozono, C. et al. 2014. Molecular basis of a dominant T cell response to an HIV reverse transcriptase 8-mer epitope presented by the protective allele HLA-B*51:01. The Journal of Immunology 192 (7), pp.3428-3434. (10.4049/jimmunol.1302667)

2013

• van den Berg, H. A. et al., 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4 250. (10.3389/fimmu.2013.00250)
• Motozono, C. et al., 2013. CD8+ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS ONE 8 (6) e66152. (10.1371/journal.pone.0066152)
• Xu, W. et al., 2013. The nucleocapsid protein of rift valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses. PLoS ONE 8 (3) e59210. (10.1371/journal.pone.0059210)
• Eukeruche-Makinde, J. et al., 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121 (7), pp.1112-1123. (10.1182/blood-2012-06-437202)
• Cole, D. et al. 2013. T-cell Receptor (TCR)-Peptide Specificity Overrides Affinity-enhancing TCR-Major Histocompatibility Complex Interactions. Journal of Biological Chemistry 289 (2), pp.628-638. (10.1074/jbc.M113.522110)
• Challier, J. et al., 2013. Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T-cell priming capacity. Immunology 138 (4), pp.402-410. (10.1111/imm.12053)
• Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121 (7), pp.1112-1123. (10.1182/blood-2012-06-437202)
• Knight, R. R. et al., 2013. Human β-cell killing by autoreactive preproinsulin-specific cd8 t cells is predominantly granule-mediated with the potency dependent upon t-cell receptor avidity. Diabetes 62 (1), pp.205-213. (10.2337/db12-0315)
• Madura, F. et al. 2013. T-cell receptor specificity maintained by altered thermodynamics. Journal of Biological Chemistry 288 (26), pp.18766-18775. (10.1074/jbc.M113.464560)
• Pentier, J. M. , Sewell, A. K. and Miles, J. J. 2013. Advances in T-Cell Epitope Engineering. Frontiers in Immunology 4 133. (10.3389/fimmu.2013.00133)
• Welton, J. et al. 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28 (3), pp.464-471. (10.1002/jbmr.1797)

2012

• Ekeruche-Makinde, J. et al., 2012. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. Journal of Biological Chemistry 287 (44), pp.37269-37281. (10.1074/jbc.M112.386409)
• Cole, D. K. et al. 2012. The molecular determinants of CD8 co-receptor function. Immunology 137 (2), pp.139-148. (10.1111/j.1365-2567.2012.03625.x)
• Holland, C. J. et al. 2012. Minimal conformational plasticity enables TCR cross-reactivity to different MHC class II heterodimers. Scientific Reports 2 629. (10.1038/srep00629)
• Liddy, N. et al., 2012. Monoclonal TCR-redirected tumor cell killing. Nature Medicine 18 (6), pp.980-987. (10.1038/nm.2764)
• Cole, D. et al. 2012. Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4+ T-cell repertoire selection. Nature Communications 3 665. (10.1038/ncomms1665)
• Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287 (2), pp.1168-1177. (10.1074/jbc.M111.289488)
• Bridgeman, J. S. et al. 2012. Structural and biophysical determinants of ab T-cell antigen recognition. Immunology 135 (1), pp.9-18. (10.1111/j.1365-2567.2011.03515.x)
• Bulek, A. M. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13 (3), pp.283-289. (10.1038/ni.2206)
• Bulek, A. M. et al. 2012. TCR/pMHC optimized protein crystallization screen. Journal of Immunological Methods 382 (1-2), pp.203-210. (10.1016/j.jim.2012.06.007)
• Matthews, P. C. et al., 2012. Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single gag epitope. Journal of Virology 86 (23), pp.12643-12654. (10.1128/JVI.01381-12)
• Sewell, A. K. 2012. Why must T cells be cross-reactive?. Nature Reviews Immunology 12 (9), pp.669-677. (10.1038/nri3279)

2011

• Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2), pp.654-663. (10.4049/jimmunol.1003941)
• Laugel, B. F. et al. 2011. The multiple roles of the CD8 coreceptor in T cell biology: opportunities for the selective modulation of self-reactive cytotoxic T cells. Journal of Leukocyte Biology 90 (6), pp.1089-1099. (10.1189/jlb.0611316)
• Miles, K. M. et al. 2011. Real time detection of peptide-MHC dissociation reveals that improvement of primary MHC-binding residues can have a minimal, or no, effect on stability. Molecular Immunology 48 (4), pp.728-732. (10.1016/j.molimm.2010.11.004)

2010

• Cole, D. et al. 2010. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. The Journal of Immunology 185 (4), pp.2600-2610. (10.4049/jimmunol.1000629)
• Wooldridge, L. et al. 2010. CD8 controls T cell cross-reactivity. The Journal of Immunology 185 (8), pp.4625-4632. (10.4049/jimmunol.1001480)
• Chen, J. et al., 2010. Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor. The Journal of Immunology 184 (4), pp.1829-1839. (10.4049/jimmunol.0902103)
• Miles, J. J. et al. 2010. Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection. PLoS Pathogens 6 (11) e1001198. (10.1371/journal.ppat.1001198)
• Schaubert, K. L. et al., 2010. Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. European Journal of Immunology 40 (7), pp.1950-1962. (10.1002/eji.200940079)
• Walker, L. J. , Sewell, A. K. and Klenerman, P. 2010. T cell sensitivity and the outcome of viral infection. Clinical and Experimental Immunology 159 (3), pp.245-255. (10.1111/j.1365-2249.2009.04047.x)
• Wooldridge, L. et al. 2010. MHC Class I molecules with superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs. Journal of Immunology 184 (7), pp.3357-3366. (10.4049/jimmunol.0902398)

2009

• Borbulevych, O. Y. et al., 2009. T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity 31 (6), pp.885-896. (10.1016/j.immuni.2009.11.003)
• Hoffman, M. et al., 2009. Novel tetramer technology for the detection of high affinity CD8 T cells [Conference poster abstract]. Retrovirology 6 (S3) P409. (10.1186/1742-4690-6-S3-P409)
• Lissina, A. et al., 2009. Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers. Journal of Immunological Methods 340 (1), pp.11-24. (10.1016/j.jim.2008.09.014)
• Choudhuri, K. et al., 2009. Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation. Journal of Biological Chemistry 284 (38), pp.26096-26105. (10.1074/jbc.M109.039966)
• Cole, D. et al. 2009. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. Journal of Biological Chemistry 284 (40) 27281-27289. (10.1074/jbc.M109.022509)
• Horlock, C. et al., 2009. ELISPOT and functional T cell analyses using HLA mono-specific target cells. Journal of Immunological Methods 350 (1-2), pp.150-160. (10.1016/j.jim.2009.08.011)
• Jo, J. et al., 2009. Analysis of CD8+ T-Cell-Mediated Inhibition of Hepatitis C Virus Replication Using a Novel Immunological Model. Gastroenterology 136 (4), pp.1391-1401. (10.1053/j.gastro.2008.12.034)
• Wooldridge, L. et al. 2009. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Immunology 126 (2), pp.147-164. (10.1111/j.1365-2567.2008.02848.x)

2008

• Melenhorst, J. J. et al., 2008. Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. Journal of Immunological Methods 338 (1-2), pp.31-39. (10.1016/j.jim.2008.07.008)
• Chattopadhyay, P. K. et al., 2008. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+T cells with peptide-major histocompatibility complex class I tetramers. Cytometry Part A 73A (11), pp.1001-1009. (10.1002/cyto.a.20642)
• Cole, D. et al. 2008. T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding. Molecular Immunology 45 (9), pp.2700-2709. (10.1016/j.molimm.2007.12.009)
• Kasprowicz, V. et al., 2008. Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. Journal of Clinical Investigation 118 (3), pp.1143-1153. (10.1172/JCI33082)
• Scriba, T. J. et al., 2008. The staphyloccous aureus eap protein activates expression of proinflammatory cytokines. Infection and Immunity 76 (5), pp.2164-2168. (10.1128/IAI.01699-07)
• Skowera, A. et al., 2008. CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. Journal of Clinical Investigation 118 (10), pp.3390-3402. (10.1172/JCI35449)
• Varela-Rohena, A. et al., 2008. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nature Medicine 14 (12), pp.1390-1395. (10.1038/nm.1779)
• Weichsel, R. et al., 2008. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clinical Cancer Research 14 (8), pp.2484-2491. (10.1158/1078-0432.CCR-07-4393)

2007

• Laugel, B. F. et al. 2007. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotxic T lymphocyte activation and tetramer properties. The Journal of Biological Chemistry 282 (33), pp.23799-22810. (10.1074/jbc.M700976200)
• Cole, D. et al. 2007. Human TCR-binding affinity is governed by MHC class restriction. The Journal of Immunology 178 (9), pp.5727-5734. (10.4049/​jimmunol.178.9.5727)
• Wooldridge, L. et al. 2007. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. European Journal of Immunology 37 (5), pp.1323-1333. (10.1002/eji.200636765)
• Gostick, E. et al., 2007. Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor. European Journal of Immunology 37 (2), pp.479-486. (10.1002/eji.200636243)
• Boulter, J. M. et al. 2007. Potent T cell agonism mediated by a very rapid TCR/pMHC interaction. European Journal of Immunology 37 (3), pp.798-806. (10.1002/eji.200636743)
• Laugel, B. et al., 2007. CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. European Journal of Immunology 37 (4), pp.905-913. (10.1002/eji.200636718)
• Schaubert, K. L. et al., 2007. Availability of a diversely Avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 gag p2419-27 epitope. The Journal of Immunology 178 (12), pp.7756-7766. (10.4049/jimmunol.178.12.7756)
• Yuan, F. et al., 2007. Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex. Acta Crystallographica Section F: Structural Biology and Crystallization Communications 63 (9), pp.758-760. (10.1107/S1744309107037244)

2006

• Wooldridge, L. et al. 2006. Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers. European Journal of Immunology 36 (7), pp.1847-1855. (10.1002/eji.200635886)
• Laugel, B. , Price, D. and Sewell, A. K. 2006. On the path to TCR-directed therapeutics. Nature Biotechnology 24 (6), pp.615-616. (10.1038/nbt0606-615b)

2005

• Price, D. et al. 2005. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. Journal of Experimental Medicine 202 (10), pp.1349-61. (10.1084/jem.20051357)
• Wooldridge, L. et al. 2005. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. The Journal of Biological Chemistry 280 (30), pp.27491-27501. (10.1074/jbc.M500555200)
• Sewell, A. et al. 2005. Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA. Journal of Experimental Medicine 201 (6), pp.891-902. (10.1084/jem.20041455)
• Laugel, B. et al., 2005. Design of soluble recombinant T Cell receptors for antigen targeting and T cell inhibition. Journal of Biological Chemistry 280 (3), pp.1882-1892. (10.1074/jbc.M409427200)
• Hewitt, R. E. et al., 2005. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clinical and Experimental Immunology 139 (1), pp.101-111. (10.1111/j.1365-2249.2005.02665.x)
• Rezvani, K. et al., 2005. T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization.. Clinical Cancer Research 11 (24), pp.8799-8807. (10.1158/1078-0432.CCR-05-1314)

2004

• Green, A. E. et al., 2004. Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin. Clinical & Experimental Immunology 136 (3), pp.472-482. (10.1111/j.1365-2249.2004.02472.x)

2003

• Wooldridge, L. et al. 2003. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J Immunol 171 , pp.6650-60.

2002

• Glick, M. et al., 2002. Novel CD8+ T cell antagonists based on 2-Microglobulin. Journal of Biological Chemistry 277 (23), pp.20840-20846. (10.1074/jbc.M201819200)
• Kelleher, A. D. , Sewell, A. K. and Price, D. 2002. Dyslipidemia due to retroviral protease inhibitors [Letter]. Nature Medicine 8 (4), pp.308. (10.1038/nm0402-308a)

2001

• Sewell, A. K. et al. 2001. A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity 14 (5), pp.591-602. (10.1016/S1074-7613(01)00133-9)
• Oxenius, A. et al., 2001. Cross-staining of cytotoxic T lymphocyte populations with peptide-MHC class I multimers of natural HIV-1 variant antigens. AIDS 15 (1), pp.121-122. (10.1097/00002030-200101050-00018)
• Purbhoo, M. A. et al., 2001. The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor chain. Journal of Biological Chemistry 276 (35), pp.32786-32792. (10.1074/jbc.M102498200)
• Sewell, A. K. and Price, D. 2001. Dendritic cells and transmission of HIV-1. Trends in Immunology 22 (4), pp.173-175. (10.1016/S1471-4906(01)01866-X)

2000

• Oxenius, A. et al., 2000. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 97 (7), pp.3382-3387. (10.1073/pnas.97.7.3382)

1999

• Price, D. et al. 1999. Cytotoxic T lymphocytes, chemokines and antiviral immunity. Immunology Today 20 (5), pp.212-216. (10.1016/S0167-5699(99)01447-4)
• Sewell, A. K. et al. 1999. Antagonism of cytotoxic T-lymphocyte activation by soluble CD8. Nature Medicine 5 , pp.399-404. (10.1038/7398)

1998

• Lewis, J. W. et al., 1998. HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. European Journal of Immunology 28 , pp.3214-3220.
• Price, D. et al. 1998. Antigen-specific release of b-chemokines by anti-HIV-1 cytotoxic T lymphocytes. Current Biology 8 (6), pp.355-358. (10.1016/S0960-9822(98)70138-1)

1997

• Sewell, A. K. et al. 1997. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. European Journal of Immunology 27 (9), pp.2323-2329. (10.1002/eji.1830270929)
• Price, D. et al. 1997. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proceedings of the National Academy of Sciences 94 (5), pp.1890-1895. (10.1073/pnas.94.5.1890)