![Katherine Smith FHEA PhD (Cantab) ARCS BSc](https://profiles-cardiff.imgix.net/attachments/1223?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Katherine Smith
FHEA PhD (Cantab) ARCS BSc
Darlithydd
- Ar gael fel goruchwyliwr ôl-raddedig
Ysgol y Biowyddorau
Trosolwyg
Rwy'n Ddarlithydd Biofeddygaeth yn Ysgol y Biowyddorau. Mae gen i ddiddordeb yn effaith immune-regulation sy'n cael ei yrru gan bathogenau ar anhwylderau llidiol, yn enwedig y rhyngweithio rhwng haint parasit helminth a chanser. Mae fy niddordebau yn ymestyn i sut mae ffactorau risg eraill ar gyfer canser, fel deiet, yn dylanwadu ar ymatebion imiwnedd gwesteiwr , metaboledd a microbiota y perfedd.
Mae fy ngrŵp yn gysylltiedig â'r grŵp Microbiomau, Microbau a Gwybodeg (MMI) yn Ysgol y Biowyddorau Caerdydd.
Mae gennyf swydd Cydymaith Ymchwil Anrhydeddus ym Mhrifysgol Cape Town, De Affrica
Rwyf hefyd yn Gymrawd Addysg Prifysgol Caerdydd
Gallwch hefyd ddod o hyd i'n gwybodaeth cyhoeddi ar ResearchGate. Os gwelwch yn dda, peidiwch ag oedi cyn fy nilyn ar Twitter.
Cyhoeddiad
2024
- Reed, E. K. and Smith, K. A. 2024. Using our understanding of interactions between helminth metabolism and host immunity to target worm survival. Trends in Parasitology 40(7), pp. 549-561. (10.1016/j.pt.2024.05.006)
2023
- de Lange, A. et al. 2023. Cestode larvae excite host neuronal circuits via glutamatergic signaling. eLife 2023, article number: 88174.1. (10.7554/eLife.88174.1)
2022
- Katsandegwaza, B., Horsnell, W. and Smith, K. 2022. Inflammatory bowel disease: A review of pre-clinical murine models of human disease. International Journal of Molecular Sciences 23(16), article number: 9344. (10.3390/ijms23169344)
2021
- Chetty, A. et al. 2021. Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection. Cell Host and Microbe 29(4), pp. 579-593. (10.1016/j.chom.2021.02.004)
2020
- Mitre, E. et al. 2020. Taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling. PLoS Neglected Tropical Diseases 14(12), article number: e0008966. (10.1371/journal.pntd.0008966)
- Chetty, A. et al. 2020. Impact of helminth infections on female reproductive health and associated diseases. Frontiers in Immunology 11, article number: 577516. (10.3389/fimmu.2020.577516)
- Jacobs, B., Prince, S. and Smith, K. A. 2020. Gastrointestinal nematode-derived antigens alter colorectal cancer cell proliferation and migration through regulation of cell cycle and epithelial-mesenchymal transition proteins. International Journal of Molecular Sciences 21(21), article number: 7845. (10.3390/ijms21217845)
2019
- Darby, M. G. et al. 2019. Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. Science Advances 5(5), article number: eaav3058. (10.1126/sciadv.aav3058)
- Löser, S., Smith, K. A. and Maizels, R. M. 2019. Innate lymphoid cells in helminth infections-obligatory or accessory?. Frontiers in Immunology 10, pp. -., article number: 620. (10.3389/fimmu.2019.00620)
2018
- Smith, K. A., Löser, S., Varyani, F., Harcus, Y., McSorley, H. J., McKenzie, A. N. J. and Maizels, R. M. 2018. Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion. eLife 7, article number: e38269. (10.7554/eLife.38269)
- Jacobs, B., Chetty, A., Horsnell, W. G. C., Shafer, G., Prince, S. and Smith, K. A. 2018. Hookworm exposure decreases human papillomavirus uptake and cervical cancer cell migration through systemic regulation of epithelial-mesenchymal transition marker expression.. Scientific Reports 8, article number: 11547. (10.1038/s41598-018-30058-9)
2017
- Godkin, A. and Smith, K. 2017. Chronic infections with viruses or parasites: breaking bad to make good. Immunology 150(4), pp. 389-396. (10.1111/imm.12703)
2016
- Smith, K. A. et al. 2016. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunology 9(2), pp. 428-443. (10.1038/mi.2015.73)
- Thawer, S. et al. 2016. Surfactant Protein-D is essential for immunity to helminth infection. PLoS Pathogens 12(2), article number: e1005461. (10.1371/journal.ppat.1005461)
2014
- McSorley, H. J., Blair, N. F., Smith, K. A., McKenzie, A. N. J. and Maizels, R. M. 2014. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunology 7(5), pp. 1068-1078. (10.1038/mi.2013.123)
- Reynolds, L. A. et al. 2014. MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite heligmosomoides polygyrus. The Journal of Immunology 193(6), pp. 2984-2993. (10.4049/jimmunol.1401056)
- Reynolds, L. A. et al. 2014. Commensal-pathogen interactions in the intestinal tract. Gut Microbes 5(4), pp. 522-532. (10.4161/gmic.32155)
- Filbey, K. J. et al. 2014. Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunology and Cell Biology 92, pp. 436-448. (10.1038/icb.2013.109)
- Smith, K. A. and Maizels, R. M. 2014. IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo. European Journal of Immunology 44(1), pp. 150-161. (10.1002/eji.201343746)
2010
- Grainger, J. R. et al. 2010. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. Journal of Experimental Medicine 207(11), pp. 2331-2341. (10.1084/jem.20101074)
- Phythian-Adams, A. T. et al. 2010. CD11c depletion severely disrupts Th2 induction and development in vivo. Journal of Experimental Medicine 207(10), pp. 2089-2096. (10.1084/jem.20100734)
Articles
- Reed, E. K. and Smith, K. A. 2024. Using our understanding of interactions between helminth metabolism and host immunity to target worm survival. Trends in Parasitology 40(7), pp. 549-561. (10.1016/j.pt.2024.05.006)
- de Lange, A. et al. 2023. Cestode larvae excite host neuronal circuits via glutamatergic signaling. eLife 2023, article number: 88174.1. (10.7554/eLife.88174.1)
- Katsandegwaza, B., Horsnell, W. and Smith, K. 2022. Inflammatory bowel disease: A review of pre-clinical murine models of human disease. International Journal of Molecular Sciences 23(16), article number: 9344. (10.3390/ijms23169344)
- Chetty, A. et al. 2021. Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection. Cell Host and Microbe 29(4), pp. 579-593. (10.1016/j.chom.2021.02.004)
- Mitre, E. et al. 2020. Taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling. PLoS Neglected Tropical Diseases 14(12), article number: e0008966. (10.1371/journal.pntd.0008966)
- Chetty, A. et al. 2020. Impact of helminth infections on female reproductive health and associated diseases. Frontiers in Immunology 11, article number: 577516. (10.3389/fimmu.2020.577516)
- Jacobs, B., Prince, S. and Smith, K. A. 2020. Gastrointestinal nematode-derived antigens alter colorectal cancer cell proliferation and migration through regulation of cell cycle and epithelial-mesenchymal transition proteins. International Journal of Molecular Sciences 21(21), article number: 7845. (10.3390/ijms21217845)
- Darby, M. G. et al. 2019. Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. Science Advances 5(5), article number: eaav3058. (10.1126/sciadv.aav3058)
- Löser, S., Smith, K. A. and Maizels, R. M. 2019. Innate lymphoid cells in helminth infections-obligatory or accessory?. Frontiers in Immunology 10, pp. -., article number: 620. (10.3389/fimmu.2019.00620)
- Smith, K. A., Löser, S., Varyani, F., Harcus, Y., McSorley, H. J., McKenzie, A. N. J. and Maizels, R. M. 2018. Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion. eLife 7, article number: e38269. (10.7554/eLife.38269)
- Jacobs, B., Chetty, A., Horsnell, W. G. C., Shafer, G., Prince, S. and Smith, K. A. 2018. Hookworm exposure decreases human papillomavirus uptake and cervical cancer cell migration through systemic regulation of epithelial-mesenchymal transition marker expression.. Scientific Reports 8, article number: 11547. (10.1038/s41598-018-30058-9)
- Godkin, A. and Smith, K. 2017. Chronic infections with viruses or parasites: breaking bad to make good. Immunology 150(4), pp. 389-396. (10.1111/imm.12703)
- Smith, K. A. et al. 2016. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunology 9(2), pp. 428-443. (10.1038/mi.2015.73)
- Thawer, S. et al. 2016. Surfactant Protein-D is essential for immunity to helminth infection. PLoS Pathogens 12(2), article number: e1005461. (10.1371/journal.ppat.1005461)
- McSorley, H. J., Blair, N. F., Smith, K. A., McKenzie, A. N. J. and Maizels, R. M. 2014. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunology 7(5), pp. 1068-1078. (10.1038/mi.2013.123)
- Reynolds, L. A. et al. 2014. MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite heligmosomoides polygyrus. The Journal of Immunology 193(6), pp. 2984-2993. (10.4049/jimmunol.1401056)
- Reynolds, L. A. et al. 2014. Commensal-pathogen interactions in the intestinal tract. Gut Microbes 5(4), pp. 522-532. (10.4161/gmic.32155)
- Filbey, K. J. et al. 2014. Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunology and Cell Biology 92, pp. 436-448. (10.1038/icb.2013.109)
- Smith, K. A. and Maizels, R. M. 2014. IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo. European Journal of Immunology 44(1), pp. 150-161. (10.1002/eji.201343746)
- Grainger, J. R. et al. 2010. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. Journal of Experimental Medicine 207(11), pp. 2331-2341. (10.1084/jem.20101074)
- Phythian-Adams, A. T. et al. 2010. CD11c depletion severely disrupts Th2 induction and development in vivo. Journal of Experimental Medicine 207(10), pp. 2089-2096. (10.1084/jem.20100734)
- Jacobs, B., Prince, S. and Smith, K. A. 2020. Gastrointestinal nematode-derived antigens alter colorectal cancer cell proliferation and migration through regulation of cell cycle and epithelial-mesenchymal transition proteins. International Journal of Molecular Sciences 21(21), article number: 7845. (10.3390/ijms21217845)
- Darby, M. G. et al. 2019. Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. Science Advances 5(5), article number: eaav3058. (10.1126/sciadv.aav3058)
- Löser, S., Smith, K. A. and Maizels, R. M. 2019. Innate lymphoid cells in helminth infections-obligatory or accessory?. Frontiers in Immunology 10, pp. -., article number: 620. (10.3389/fimmu.2019.00620)
- Smith, K. A., Löser, S., Varyani, F., Harcus, Y., McSorley, H. J., McKenzie, A. N. J. and Maizels, R. M. 2018. Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion. eLife 7, article number: e38269. (10.7554/eLife.38269)
- Jacobs, B., Chetty, A., Horsnell, W. G. C., Shafer, G., Prince, S. and Smith, K. A. 2018. Hookworm exposure decreases human papillomavirus uptake and cervical cancer cell migration through systemic regulation of epithelial-mesenchymal transition marker expression.. Scientific Reports 8, article number: 11547. (10.1038/s41598-018-30058-9)
- Godkin, A. and Smith, K. 2017. Chronic infections with viruses or parasites: breaking bad to make good. Immunology 150(4), pp. 389-396. (10.1111/imm.12703)
- Smith, K. A. et al. 2016. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunology 9(2), pp. 428-443. (10.1038/mi.2015.73)
- Thawer, S. et al. 2016. Surfactant Protein-D is essential for immunity to helminth infection. PLoS Pathogens 12(2), article number: e1005461. (10.1371/journal.ppat.1005461)
- McSorley, H. J., Blair, N. F., Smith, K. A., McKenzie, A. N. J. and Maizels, R. M. 2014. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunology 7(5), pp. 1068-1078. (10.1038/mi.2013.123)
- Reynolds, L. A. et al. 2014. MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite heligmosomoides polygyrus. The Journal of Immunology 193(6), pp. 2984-2993. (10.4049/jimmunol.1401056)
- Reynolds, L. A. et al. 2014. Commensal-pathogen interactions in the intestinal tract. Gut Microbes 5(4), pp. 522-532. (10.4161/gmic.32155)
- Filbey, K. J. et al. 2014. Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunology and Cell Biology 92, pp. 436-448. (10.1038/icb.2013.109)
- Smith, K. A. and Maizels, R. M. 2014. IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo. European Journal of Immunology 44(1), pp. 150-161. (10.1002/eji.201343746)
- Grainger, J. R. et al. 2010. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway. Journal of Experimental Medicine 207(11), pp. 2331-2341. (10.1084/jem.20101074)
- Phythian-Adams, A. T. et al. 2010. CD11c depletion severely disrupts Th2 induction and development in vivo. Journal of Experimental Medicine 207(10), pp. 2089-2096. (10.1084/jem.20100734)
Ymchwil
I am interested in how intestinal pathogens, such as parasitic helminths, influence important inflammatory diseases, like cancer. The interaction between parasite infection and cancer is particularly important in low- and middle- income countries, where infectious disease is thought to result in over 1/3 of cancers, and where the incidence of all cancers is increasing exponentially. Our aim is to make use of our knowledge of host immune responses to helminth infection in order to control inflammatory disease and anti-parasite immunity.
Host Immune Response
Infection with helminth parasites is associated with the regulation of several inflammatory disorders including airway inflammation, type 1 diabetes, multiple sclerosis and inflammatory bowel disease. In some situations, helminth-induced “immune-regulation” could be detrimental to the host by impairing vaccine efficacy, immunity to co-infections or anti-tumour responses. We are interested in understanding how helminths influence the inflammation associated with colorectal cancer (colitis), as well as cancer progression. In addition, we wish to understand how other risk factors for cancer, such as diet change, impact on disease. We are also interested in how gastrointestinal helminth infection can have a long-term and systemic impact on host immunity, including susceptibility to human papillomavirus infections and cervical cancer progression. We hope this work will help to identify new host pathways we can target, in order to reduce the incidence of cancer.
Helminth Immunity
Over 1.5 billion people are infected with soil-transmitted helminths (24% of the world’s population). Although drug treatment exists, there are no vaccines for disease, and as long as the helminth infection remains in the soil, people in endemic areas are at risk of infection and re-infection, throughout their lifetime. Morbidity following infection is associated with a high intensity of parasites and in our hands, is determined by the immune status of the host. We aim to target host responses to parasite infection, in order to modify helminth survival and limit host morbidity.
Addysgu
Rwy'n Gymrawd Addysgu Prifysgol Caerdydd.
Mae dyfarnu'r gymrodoriaeth hon yn cydnabod cyrhaeddiad yn erbyn Fframwaith Safonau Proffesiynol y DU ar gyfer cymorth addysgu a dysgu mewn addysg uwch.
Rwy'n cynnal ystod o addysgu o flwyddyn 1 i fyfyrwyr Meistr integredig, goruchwylio PhD, myfyrwyr prosiect MSc Integredig a myfyrwyr prosiect y Flwyddyn Olaf. Rwyf hefyd yn diwtor ar gyfer myfyrwyr blwyddyn 1af-3ydd a myfyrwyr PTY ac rwy'n fentor i fyfyrwyr a staff ôl-raddedig.
Mae fy mhrofiad dysgu yn cynnwys cyfraniadau i:
- BI3351: Pynciau Cyfoes mewn Clefydau - Arweinydd Asesu
- BI3351: Pynciau Cyfoes mewn Clefydau - Darlithoedd ac Asesiad Arholiad
- BI3155: Bioleg Heintiau ac Epidemioleg - Darlithoedd ac Asesiad Arholiad
- BI3155: Bioleg Heintiau ac Epidemioleg - Asesiad o Addysgu a Gwaith Cwrs Grŵp Bach
- BI4001: Meistr Integredig - Prosiect Ymchwil Uwch
- BI4002: Meistr Integredig - Dulliau Ymchwil Uwch
- BI4003: Meistr Integredig - Ffiniau yn y Biowyddorau
- BI3001: Prosiect Blwyddyn Derfynol Biowyddorau
- BI1001: Sgiliau ar gyfer Gwyddoniaeth
- BI2231: Bioleg Cell - Clawr darlithoedd
Meysydd goruchwyliaeth
I am interested in supervising MSc and PhD students in the areas of:
- Helminth immunity
- Immune-regulation
- Cancer progression
Past projects
- Supervisor for Brittany Amber Jacobs (MSc Med Clinical Science and Immunology, University of Cape Town) - Cancer cell behaviour following parasite exposure (awarded 2018)
- Supervisor for Brunette Katsandegwaza (PhD Clinical Science and Immunology, University of Cape Town) - Determining the impact of Heligmosomoides polygyrus infection on the
development of colitis (awarded 2020)
Prosiectau'r gorffennol
- Penderfynu effaith heligmosmoides polygyrus ar ddatblygiad colitis. Brunette Katsandegwaza. PhD (Prifysgol Cape Town)
- Ymddygiad celloedd canser yn dilyn amlygiad parasitig. Jacob Llydaw-Amber MSc Med mewn Gwyddoniaeth Glinigol ac Imiwnoleg (Prifysgol Cape Town)
Contact Details
SmithK28@caerdydd.ac.uk
+44 29208 74303
Adeilad Syr Martin Evans, Ystafell W/2.05, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
+44 29208 74303
Adeilad Syr Martin Evans, Ystafell W/2.05, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
Themâu ymchwil
Arbenigeddau
- Rhyngweithio â pharasitiaid gwesteiwr
- Imiwnoleg
- Biocemeg
- Cychwyn ac Atal Canser