![Phil Stephens BSc (Hons) PhD](https://profiles-cardiff.imgix.net/attachments/1684?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Phil Stephens
(e/fe)
BSc (Hons) PhD
Pennaeth Dros Dro yr Ysgol, Deon Rhyngwladol ar gyfer America, Athro Bioleg Celloedd
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Pennaeth Dros Dro'r Ysgol, Deon Rhyngwladol America, Athro Bioleg Celloedd, Trwydded Ymchwil HTA Dynodwyd Arweinydd Unigol ac Academaidd ar gyfer Banc Bio Prifysgol Caerdydd.
Grŵp ymchwil
Grŵp Therapïau Uwch
Cyhoeddiad
2023
- Wang, Z., Knight, R., Stephens, P., Ongkosuwito, E. M., Wagener, F. A. D. T. G. and Von den Hoff, J. W. 2023. Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing. Stem Cell Research and Therapy 14(1), article number: 203. (10.1186/s13287-023-03423-3)
- Lohana, P. et al. 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12(7), article number: 1374. (10.3390/antiox12071374)
2022
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11(8), pp. 861-875. (10.1093/stcltm/szac037)
2021
- Brown, H., Clayton, A. and Stephens, P. 2021. The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges. Wound Repair and Regeneration 29(6), pp. 864-880. (10.1111/wrr.12949)
- Stephens, N. and Stephens, P. 2021. Interdisciplinary projects as an expert-network: analysing team work across biological and physical sciences. Science and Technology Studies 34(4), pp. 56-73. (10.23987/sts.87339)
2020
- Yang, Y., Knight, R., Stephens, P. and Zhang, Y. 2020. Three-dimensional culture of oral progenitor cells: effects on small extracellular vesicles production and proliferative function. Journal of Oral Pathology and Medicine 49(4), pp. 342-349. (10.1111/jop.12981)
2018
- Masia, F., Glen, A., Stephens, P., Langbein, W. and Borri, P. 2018. Label-free quantitative chemical imaging and classification analysis of adipogenesis using mouse embryonic stem cells. Journal of Biophotonics 11(7), article number: e201700219. (10.1002/jbio.201700219)
- Caley, M., Wall, I., Peake, M., Kipling, D., Giles, P., Thomas, D. and Stephens, P. 2018. Development and characterisation of a human chronic skin wound cell line - towards an alternative for animal experimentation. International Journal of Molecular Sciences 19(4), article number: 1001. (10.3390/ijms19041001)
- Hidalgo San Jose, L., Stephens, P., Song, B. and Barrow, D. 2018. Microfluidic encapsulation supports stem cell viability, proliferation and neuronal differentiation. Tissue Engineering Part C Methods 24(3), pp. 158-170. (10.1089/ten.TEC.2017.0368)
2016
- Locke, M., Davies, L. C. and Stephens, P. 2016. Oral mucosal progenitor cell clones resist In Vitro myogenic differentiation. Archives of Oral Biology 70, pp. 100-110. (10.1016/j.archoralbio.2016.06.013)
- Howard-Jones, R. A., Cheung, O. K. Y., Glen, A., Allen, N. D. and Stephens, P. 2016. Integration-free reprogramming of lamina propria progenitor cells. Journal of Dental Research 95(8), pp. 882-888. (10.1177/0022034516637579)
- Perkins, B. L. et al. 2016. The life science exchange: A case study of a sectoral and sub-sectoral knowledge exchange programme. Health Research Policy and Systems 14, article number: 32. (10.1186/s12961-016-0105-4)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11(4), article number: e0152023. (10.1371/journal.pone.0152023)
2015
- Roper, J. A. et al. 2015. Ultrasonic stimulation of mouse skin reverses the healing delays in diabetes and aging by activation of Rac1. Journal of Investigative Dermatology 135(11), pp. 2842-2851. (10.1038/jid.2015.224)
- Board-Davies, E., Moses, R., Sloan, A. J., Stephens, P. and Davies, L. C. 2015. Oral mucosal lamina propria-progenitor cells exert antibacterial properties via the secretion of osteoprotegerin and haptoglobin. Stem Cells Translational Medicine 4(11), pp. 1283-1293. (10.5966/sctm.2015-0043)
2014
- Stephens, P. and Davies, L. C. 2014. Oral mucosal progenitor cells. In: Vishwakarma, A. et al. eds. Stem Cell Biology and Tissue Engineering in Dental Sciences. Academic Press, pp. 297-306., (10.1016/B978-0-12-397157-9.00025-4)
- Peake, M. A. et al. 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22(3), pp. 399-405. (10.1111/wrr.12170)
- McInnes, R. L. et al. 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22(1), pp. 58-69. (10.1111/wrr.12133)
2013
- Stephens, P., Caley, M. and Peake, M. 2013. Alternatives for animal wound model systems. In: Gourdie, R. G. and Myers, T. A. eds. Wound Regeneration and Repair., Vol. 1037. Methods in Molecular Biology Springer, pp. 177-201., (10.1007/978-1-62703-505-7_10)
- Masia, F., Glen, A., Stephens, P., Borri, P. and Langbein, W. W. 2013. Quantitative chemical imaging and unsupervised analysis using hyperspectral coherent anti-Stokes Raman scattering microscopy. Analytical Chemistry 85(22), pp. 10820-10828. (10.1021/ac402303g)
2012
- Wildeboer, D. et al. 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31(9), pp. 2183-2189. (10.1007/s10096-012-1553-6)
- Wagstaffe, S. J., Hill, K. E., Williams, D. W., Randle, B. J., Thomas, D. W., Stephens, P. and Riley, D. J. 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84(14), pp. 5876-5884. (10.1021/ac203403d)
- Davies, L. C. et al. 2012. Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner. Stem Cells and Development 21(9), pp. 1478-1487. (10.1089/scd.2011.0434)
2011
- Stephens, P. 2011. Dysfunctional wound healing in chronic wounds. In: Farrar, D. ed. Advanced Wound Repair Therapies. Woodhead Publishing, pp. 3-38., (10.1533/9780857093301.1.3)
2010
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
- Hardwicke, J., Moseley, R., Stephens, P., Harding, K. G., Duncan, R. and Thomas, D. W. 2010. Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7(3), pp. 699-707. (10.1021/mp9002656)
- Davies, L. C. et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19(6), pp. 819-830. (10.1089/scd.2009.0089)
- Simpson, R. M. L., Wells, A., Thomas, D. W., Stephens, P., Steadman, R. and Phillips, A. O. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176(3), pp. 1215-1228. (10.2353/ajpath.2010.090802)
- Stephens, P. 2010. Development of a cell-based diabetic wound assay. ATLA Alternatives to Laboratory Animals 38(SUPPL.), pp. 45-48.
2009
- Simpson, R. M. L., Meran, S., Thomas, D. W., Stephens, P., Bowen, T., Steadman, R. and Phillips, A. O. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175(5), pp. 1915-1928. (10.2353/ajpath.2009.090045)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
- Iversen, A. et al. 2009. A proviral role for CpG in cytomegalovirus infection. Journal of Immunology 182(9), pp. 5672-5681. (10.4049/jimmunol.0801268)
- Simpson, R. M., Stephens, P., Thomas, D., Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90(2), pp. A128-A129.
- Cook, H., Stephens, P., Davies, K. J., Harding, K. G. and Thomas, D. W. 2009. Phenotypic differences in wound healing responses are reflected by differences in ECM reorganisation and MMP-2 activation. Journal of Gastroenterology and Hepatology 24, pp. A88-A88. (10.1046/j.1365-2613.2000.0145k.x)
- Enoch, S. and Stephens, P. 2009. Scarless healing: Oral mucosa as a scientific model. Wounds UK 5(1), pp. 42-48.
2008
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Hardwicke, J., Ferguson, E. L., Moseley, R., Stephens, P., Thomas, D. W. and Duncan, R. 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130(3), pp. 275-283. (10.1016/j.jconrel.2008.07.023)
- Meran, S., Thomas, D. W., Stephens, P., Enoch, S., Martin, J., Steadman, R. and Phillips, A. O. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283(10), pp. 6530-6545. (10.1074/jbc.M704819200)
- Enoch, S., Moseley, R., Stephens, P. and Thomas, D. W. 2008. The oral mucosa: A model of wound healing with reduced scarring. Oral Surgery 1, pp. 11-21. (10.1111/j.1752-248x.2007.00005.x)
- Peake, M. A., Giles, P. J., Wall, I. B., Enoch, S., Kipling, D. G., Thomas, D. W. and Stephens, P. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16(6), pp. A71. (10.1111/j.1524-475X.2008.00424.x)
- Mantripragada, K. K. et al. 2008. Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals. Genes Chromosomes and Cancer 47(3), pp. 238-246. (10.1002/gcc.20525)
- Meran, S., Steadman, R., Phillips, A. O., Thomas, D. W. and Stephens, P. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16(2), pp. A12. (10.1111/j.1524-475X.2008.00371.x)
2007
- Lygoe, K. A., Wall, I., Stephens, P. and Lewis, M. P. 2007. Role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation. Biology of the Cell 99(11), pp. 601-614. (10.1042/BC20070008)
- Meran, S., Thomas, D. W., Stephens, P., Martin, J., Bowen, T., Phillips, A. O. and Steadman, R. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282(35), pp. 25687-25697. (10.1074/jbc.M700773200)
- Davies, C. E., Hill, K. E., Newcombe, R. G., Stephens, P., Wilson, M., Harding, K. G. and Thomas, D. W. 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15(1), pp. 17-22. (10.1111/j.1524-475X.2006.00180.x)
- Stephens, P. and Genever, P. 2007. Non-epithelial oral mucosal progenitor cell populations. Oral Diseases 13(1), pp. 1-10. (10.1111/j.1601-0825.2006.01314.x)
- Andersen, A., Hill, K. E., Stephens, P., Thomas, D. W., Jorgensen, B. and Krogfelt, K. A. 2007. Bacterial profiling using skin grafting, standard culture and molecular bacteriological methods. Journal of Wound Care 16(4), pp. 171-175.
2004
- Davies, C. E., Hill, K. E., Wilson, M., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42(8), pp. 3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
- Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117(15), pp. 3389-3403. (10.1242/jcs.01188)
- Enoch, S., Price, P. E., Harding, K. G., Thomas, D. W. and Stephens, P. 2004. Identifying the molecular and genetic basis for non-healing wounds, scarless healing and scarring: study of human fibroblasts. British Journal of Surgery 91(S1), pp. 82-82.
- Moseley, R., Stewart, J. E., Stephens, P., Waddington, R. J. and Thomas, D. W. 2004. Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?. British Journal of Dermatology 150(3), pp. 401-413. (10.1111/j.1365-2133.2004.05845.x)
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
2003
- Hill, K. E., Davies, C. E., Wilson, M., Stephens, P., Harding, K. G. and Thomas, D. W. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52(4), pp. 365-369. (10.1099/jmm.0.05030-0)
- Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148(3), pp. 456-466. (10.1046/j.1365-2133.2003.05232.x)
- Stephens, P. et al. 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283(1), pp. 22-35. (10.1016/S0014-4827(02)00021-6)
- White, P., Thomas, D. W., Fong, S., Stelnicki, E., Meijlink, F., Largman, C. and Stephens, P. 2003. Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. Journal Of Investigative Dermatology 120(1), pp. 135-144. (10.1046/j.1523-1747.2003.12015.x)
2002
- Hill, K. E. et al. 2002. Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51(11), pp. 949-957.
- Wall, I. B., Davies, C. E., Hill, K. E., Wilson, M. J., Stephens, P., Harding, K. G. and Thomas, D. W. 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10(6), pp. 346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
- Stephens, P. and Thomas, D. W. 2002. The cellular proliferative phase of the wound repair process. Journal of Wound Care 11(7), pp. 253-261. (10.12968/jowc.2002.11.7.26421)
2001
- Davies, C. E., Wilson, M. J., Hill, K. E., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9(5), pp. 332-340. (10.1046/j.1524-475x.2001.00332.x)
- Stephens, P. et al. 2001. Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity. British Journal Of Dermatology 144(2), pp. 229-237. (10.1046/j.1365-2133.2001.04006.x)
- Stephens, P., Hiscox, S. E., Cook, H., Jiang, W. G., Zhiquiang, W. and Thomas, D. W. 2001. Phenotypic variation in the production of bioactive hepatocyte growth factor/scatter factor by oral mucosal and skin fibroblasts. Wound Repair and Regeneration 9(1), pp. 34-43. (10.1046/j.1524-475x.2001.00034.x)
2000
- Cook, H., Stephens, P., Davies, K. J., Thomas, D. W. and Harding, K. G. 2000. Defective Extracellular Matrix Reorganization by Chronic Wound Fibroblasts is Associated with Alterations in TIMP-1, TIMP-2, and MMP-2 Activity. Journal of Investigative Dermatology 115(2), pp. 225-233. (10.1046/j.1523-1747.2000.00044.x)
- Thomas, D. W., Hill, C. M., Lewis, M. A. O., Stephens, P., Walker, R. and Von Der Weth, A. 2000. Randomized clinical trial of the effect of semi-occlusive dressings on the microflora and clinical outcome of acute facial wounds. Wound Repair and Regeneration 8(4), pp. 258-263. (10.1046/j.1524-475x.2000.00258.x)
1998
- Stephens, M., Lim, K., Stephens, P., Lim, S. H. and Thomas, D. W. 1998. Molecular characterisation of tumour infiltrating lymphocytes in oral squamous cell carcinoma. Cancer Immunology, Immunotherapy 46(1), pp. 34-40. (10.1007/s002620050457)
1997
- Lim, S. H., Stephens, P., Cao, Q., Coleman, S. L. and Thomas, D. 1997. Molecular analysis of T cell receptor beta variability in a patient with orofacial granulomatosis. Gut 40(5), pp. 683-686. (10.1136/gut.40.5.683)
- Thomas, D. W., Stephens, P., Stephens, M., Patten, D. W. and Lim, S. H. 1997. T-cell receptor Vbeta usage by lesional lymphocytes in oral lichen planus. Journal of Oral Pathology & Medicine 26(3), pp. 105-109. (10.1111/j.1600-0714.1997.tb00031.x)
- al-Khateeb, T., Stephens, P., Shepherd, J. and Thomas, D. 1997. An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model. Journal of Periodontology 68(11), pp. 1063-1069. (10.1902/jop.1997.68.11.1063)
- Stephens, P., Genever, P. G., Wood, E. J. and Raxworthy, M. J. 1997. Integrin receptor involvement in actin cable formation in an in vitro model of events associated with wound contraction. The International Journal of Biochemistry & Cell Biology 29(1), pp. 121-128. (10.1016/S1357-2725(96)00123-9)
1996
- Stephens, P., Davies, K. J., Al-Khateeb, T., Shepherd, J. P. and Thomas, D. W. 1996. A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction. Journal of Dental Research 75(6), pp. 1358-1364. (10.1177/00220345960750060601)
- Stephens, P., Al-Khateeb, T., Davies, K. J., Shepherd, J. P. and Thomas, D. W. 1996. An investigation of the interaction between alcohol and fibroblasts in wound healing. International Journal of Oral and Maxillofacial Surgery 25(2), pp. 161-164. (10.1016/S0901-5027(96)80065-8)
- Lim, S. H., Thomas, D. W., Coleman, S. L. and Stephens, P. 1996. T cell receptor Vβ repertoire of tumour-infiltrating lymphocytes in oral squamous-cell carcinoma. Cancer Immunology, Immunotherapy 42(1), pp. 69-70. (10.1007/s002620050253)
Adrannau llyfrau
- Stephens, P. and Davies, L. C. 2014. Oral mucosal progenitor cells. In: Vishwakarma, A. et al. eds. Stem Cell Biology and Tissue Engineering in Dental Sciences. Academic Press, pp. 297-306., (10.1016/B978-0-12-397157-9.00025-4)
- Stephens, P., Caley, M. and Peake, M. 2013. Alternatives for animal wound model systems. In: Gourdie, R. G. and Myers, T. A. eds. Wound Regeneration and Repair., Vol. 1037. Methods in Molecular Biology Springer, pp. 177-201., (10.1007/978-1-62703-505-7_10)
- Stephens, P. 2011. Dysfunctional wound healing in chronic wounds. In: Farrar, D. ed. Advanced Wound Repair Therapies. Woodhead Publishing, pp. 3-38., (10.1533/9780857093301.1.3)
Erthyglau
- Wang, Z., Knight, R., Stephens, P., Ongkosuwito, E. M., Wagener, F. A. D. T. G. and Von den Hoff, J. W. 2023. Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing. Stem Cell Research and Therapy 14(1), article number: 203. (10.1186/s13287-023-03423-3)
- Lohana, P. et al. 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12(7), article number: 1374. (10.3390/antiox12071374)
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11(8), pp. 861-875. (10.1093/stcltm/szac037)
- Brown, H., Clayton, A. and Stephens, P. 2021. The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges. Wound Repair and Regeneration 29(6), pp. 864-880. (10.1111/wrr.12949)
- Stephens, N. and Stephens, P. 2021. Interdisciplinary projects as an expert-network: analysing team work across biological and physical sciences. Science and Technology Studies 34(4), pp. 56-73. (10.23987/sts.87339)
- Yang, Y., Knight, R., Stephens, P. and Zhang, Y. 2020. Three-dimensional culture of oral progenitor cells: effects on small extracellular vesicles production and proliferative function. Journal of Oral Pathology and Medicine 49(4), pp. 342-349. (10.1111/jop.12981)
- Masia, F., Glen, A., Stephens, P., Langbein, W. and Borri, P. 2018. Label-free quantitative chemical imaging and classification analysis of adipogenesis using mouse embryonic stem cells. Journal of Biophotonics 11(7), article number: e201700219. (10.1002/jbio.201700219)
- Caley, M., Wall, I., Peake, M., Kipling, D., Giles, P., Thomas, D. and Stephens, P. 2018. Development and characterisation of a human chronic skin wound cell line - towards an alternative for animal experimentation. International Journal of Molecular Sciences 19(4), article number: 1001. (10.3390/ijms19041001)
- Hidalgo San Jose, L., Stephens, P., Song, B. and Barrow, D. 2018. Microfluidic encapsulation supports stem cell viability, proliferation and neuronal differentiation. Tissue Engineering Part C Methods 24(3), pp. 158-170. (10.1089/ten.TEC.2017.0368)
- Locke, M., Davies, L. C. and Stephens, P. 2016. Oral mucosal progenitor cell clones resist In Vitro myogenic differentiation. Archives of Oral Biology 70, pp. 100-110. (10.1016/j.archoralbio.2016.06.013)
- Howard-Jones, R. A., Cheung, O. K. Y., Glen, A., Allen, N. D. and Stephens, P. 2016. Integration-free reprogramming of lamina propria progenitor cells. Journal of Dental Research 95(8), pp. 882-888. (10.1177/0022034516637579)
- Perkins, B. L. et al. 2016. The life science exchange: A case study of a sectoral and sub-sectoral knowledge exchange programme. Health Research Policy and Systems 14, article number: 32. (10.1186/s12961-016-0105-4)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11(4), article number: e0152023. (10.1371/journal.pone.0152023)
- Roper, J. A. et al. 2015. Ultrasonic stimulation of mouse skin reverses the healing delays in diabetes and aging by activation of Rac1. Journal of Investigative Dermatology 135(11), pp. 2842-2851. (10.1038/jid.2015.224)
- Board-Davies, E., Moses, R., Sloan, A. J., Stephens, P. and Davies, L. C. 2015. Oral mucosal lamina propria-progenitor cells exert antibacterial properties via the secretion of osteoprotegerin and haptoglobin. Stem Cells Translational Medicine 4(11), pp. 1283-1293. (10.5966/sctm.2015-0043)
- Peake, M. A. et al. 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22(3), pp. 399-405. (10.1111/wrr.12170)
- McInnes, R. L. et al. 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22(1), pp. 58-69. (10.1111/wrr.12133)
- Masia, F., Glen, A., Stephens, P., Borri, P. and Langbein, W. W. 2013. Quantitative chemical imaging and unsupervised analysis using hyperspectral coherent anti-Stokes Raman scattering microscopy. Analytical Chemistry 85(22), pp. 10820-10828. (10.1021/ac402303g)
- Wildeboer, D. et al. 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31(9), pp. 2183-2189. (10.1007/s10096-012-1553-6)
- Wagstaffe, S. J., Hill, K. E., Williams, D. W., Randle, B. J., Thomas, D. W., Stephens, P. and Riley, D. J. 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84(14), pp. 5876-5884. (10.1021/ac203403d)
- Davies, L. C. et al. 2012. Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner. Stem Cells and Development 21(9), pp. 1478-1487. (10.1089/scd.2011.0434)
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
- Hardwicke, J., Moseley, R., Stephens, P., Harding, K. G., Duncan, R. and Thomas, D. W. 2010. Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7(3), pp. 699-707. (10.1021/mp9002656)
- Davies, L. C. et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19(6), pp. 819-830. (10.1089/scd.2009.0089)
- Simpson, R. M. L., Wells, A., Thomas, D. W., Stephens, P., Steadman, R. and Phillips, A. O. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176(3), pp. 1215-1228. (10.2353/ajpath.2010.090802)
- Stephens, P. 2010. Development of a cell-based diabetic wound assay. ATLA Alternatives to Laboratory Animals 38(SUPPL.), pp. 45-48.
- Simpson, R. M. L., Meran, S., Thomas, D. W., Stephens, P., Bowen, T., Steadman, R. and Phillips, A. O. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175(5), pp. 1915-1928. (10.2353/ajpath.2009.090045)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
- Iversen, A. et al. 2009. A proviral role for CpG in cytomegalovirus infection. Journal of Immunology 182(9), pp. 5672-5681. (10.4049/jimmunol.0801268)
- Simpson, R. M., Stephens, P., Thomas, D., Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90(2), pp. A128-A129.
- Cook, H., Stephens, P., Davies, K. J., Harding, K. G. and Thomas, D. W. 2009. Phenotypic differences in wound healing responses are reflected by differences in ECM reorganisation and MMP-2 activation. Journal of Gastroenterology and Hepatology 24, pp. A88-A88. (10.1046/j.1365-2613.2000.0145k.x)
- Enoch, S. and Stephens, P. 2009. Scarless healing: Oral mucosa as a scientific model. Wounds UK 5(1), pp. 42-48.
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Hardwicke, J., Ferguson, E. L., Moseley, R., Stephens, P., Thomas, D. W. and Duncan, R. 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130(3), pp. 275-283. (10.1016/j.jconrel.2008.07.023)
- Meran, S., Thomas, D. W., Stephens, P., Enoch, S., Martin, J., Steadman, R. and Phillips, A. O. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283(10), pp. 6530-6545. (10.1074/jbc.M704819200)
- Enoch, S., Moseley, R., Stephens, P. and Thomas, D. W. 2008. The oral mucosa: A model of wound healing with reduced scarring. Oral Surgery 1, pp. 11-21. (10.1111/j.1752-248x.2007.00005.x)
- Peake, M. A., Giles, P. J., Wall, I. B., Enoch, S., Kipling, D. G., Thomas, D. W. and Stephens, P. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16(6), pp. A71. (10.1111/j.1524-475X.2008.00424.x)
- Mantripragada, K. K. et al. 2008. Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals. Genes Chromosomes and Cancer 47(3), pp. 238-246. (10.1002/gcc.20525)
- Meran, S., Steadman, R., Phillips, A. O., Thomas, D. W. and Stephens, P. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16(2), pp. A12. (10.1111/j.1524-475X.2008.00371.x)
- Lygoe, K. A., Wall, I., Stephens, P. and Lewis, M. P. 2007. Role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation. Biology of the Cell 99(11), pp. 601-614. (10.1042/BC20070008)
- Meran, S., Thomas, D. W., Stephens, P., Martin, J., Bowen, T., Phillips, A. O. and Steadman, R. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282(35), pp. 25687-25697. (10.1074/jbc.M700773200)
- Davies, C. E., Hill, K. E., Newcombe, R. G., Stephens, P., Wilson, M., Harding, K. G. and Thomas, D. W. 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15(1), pp. 17-22. (10.1111/j.1524-475X.2006.00180.x)
- Stephens, P. and Genever, P. 2007. Non-epithelial oral mucosal progenitor cell populations. Oral Diseases 13(1), pp. 1-10. (10.1111/j.1601-0825.2006.01314.x)
- Andersen, A., Hill, K. E., Stephens, P., Thomas, D. W., Jorgensen, B. and Krogfelt, K. A. 2007. Bacterial profiling using skin grafting, standard culture and molecular bacteriological methods. Journal of Wound Care 16(4), pp. 171-175.
- Davies, C. E., Hill, K. E., Wilson, M., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42(8), pp. 3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
- Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117(15), pp. 3389-3403. (10.1242/jcs.01188)
- Enoch, S., Price, P. E., Harding, K. G., Thomas, D. W. and Stephens, P. 2004. Identifying the molecular and genetic basis for non-healing wounds, scarless healing and scarring: study of human fibroblasts. British Journal of Surgery 91(S1), pp. 82-82.
- Moseley, R., Stewart, J. E., Stephens, P., Waddington, R. J. and Thomas, D. W. 2004. Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?. British Journal of Dermatology 150(3), pp. 401-413. (10.1111/j.1365-2133.2004.05845.x)
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
- Hill, K. E., Davies, C. E., Wilson, M., Stephens, P., Harding, K. G. and Thomas, D. W. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52(4), pp. 365-369. (10.1099/jmm.0.05030-0)
- Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148(3), pp. 456-466. (10.1046/j.1365-2133.2003.05232.x)
- Stephens, P. et al. 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283(1), pp. 22-35. (10.1016/S0014-4827(02)00021-6)
- White, P., Thomas, D. W., Fong, S., Stelnicki, E., Meijlink, F., Largman, C. and Stephens, P. 2003. Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. Journal Of Investigative Dermatology 120(1), pp. 135-144. (10.1046/j.1523-1747.2003.12015.x)
- Hill, K. E. et al. 2002. Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51(11), pp. 949-957.
- Wall, I. B., Davies, C. E., Hill, K. E., Wilson, M. J., Stephens, P., Harding, K. G. and Thomas, D. W. 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10(6), pp. 346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
- Stephens, P. and Thomas, D. W. 2002. The cellular proliferative phase of the wound repair process. Journal of Wound Care 11(7), pp. 253-261. (10.12968/jowc.2002.11.7.26421)
- Davies, C. E., Wilson, M. J., Hill, K. E., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9(5), pp. 332-340. (10.1046/j.1524-475x.2001.00332.x)
- Stephens, P. et al. 2001. Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity. British Journal Of Dermatology 144(2), pp. 229-237. (10.1046/j.1365-2133.2001.04006.x)
- Stephens, P., Hiscox, S. E., Cook, H., Jiang, W. G., Zhiquiang, W. and Thomas, D. W. 2001. Phenotypic variation in the production of bioactive hepatocyte growth factor/scatter factor by oral mucosal and skin fibroblasts. Wound Repair and Regeneration 9(1), pp. 34-43. (10.1046/j.1524-475x.2001.00034.x)
- Cook, H., Stephens, P., Davies, K. J., Thomas, D. W. and Harding, K. G. 2000. Defective Extracellular Matrix Reorganization by Chronic Wound Fibroblasts is Associated with Alterations in TIMP-1, TIMP-2, and MMP-2 Activity. Journal of Investigative Dermatology 115(2), pp. 225-233. (10.1046/j.1523-1747.2000.00044.x)
- Thomas, D. W., Hill, C. M., Lewis, M. A. O., Stephens, P., Walker, R. and Von Der Weth, A. 2000. Randomized clinical trial of the effect of semi-occlusive dressings on the microflora and clinical outcome of acute facial wounds. Wound Repair and Regeneration 8(4), pp. 258-263. (10.1046/j.1524-475x.2000.00258.x)
- Stephens, M., Lim, K., Stephens, P., Lim, S. H. and Thomas, D. W. 1998. Molecular characterisation of tumour infiltrating lymphocytes in oral squamous cell carcinoma. Cancer Immunology, Immunotherapy 46(1), pp. 34-40. (10.1007/s002620050457)
- Lim, S. H., Stephens, P., Cao, Q., Coleman, S. L. and Thomas, D. 1997. Molecular analysis of T cell receptor beta variability in a patient with orofacial granulomatosis. Gut 40(5), pp. 683-686. (10.1136/gut.40.5.683)
- Thomas, D. W., Stephens, P., Stephens, M., Patten, D. W. and Lim, S. H. 1997. T-cell receptor Vbeta usage by lesional lymphocytes in oral lichen planus. Journal of Oral Pathology & Medicine 26(3), pp. 105-109. (10.1111/j.1600-0714.1997.tb00031.x)
- al-Khateeb, T., Stephens, P., Shepherd, J. and Thomas, D. 1997. An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model. Journal of Periodontology 68(11), pp. 1063-1069. (10.1902/jop.1997.68.11.1063)
- Stephens, P., Genever, P. G., Wood, E. J. and Raxworthy, M. J. 1997. Integrin receptor involvement in actin cable formation in an in vitro model of events associated with wound contraction. The International Journal of Biochemistry & Cell Biology 29(1), pp. 121-128. (10.1016/S1357-2725(96)00123-9)
- Stephens, P., Davies, K. J., Al-Khateeb, T., Shepherd, J. P. and Thomas, D. W. 1996. A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction. Journal of Dental Research 75(6), pp. 1358-1364. (10.1177/00220345960750060601)
- Stephens, P., Al-Khateeb, T., Davies, K. J., Shepherd, J. P. and Thomas, D. W. 1996. An investigation of the interaction between alcohol and fibroblasts in wound healing. International Journal of Oral and Maxillofacial Surgery 25(2), pp. 161-164. (10.1016/S0901-5027(96)80065-8)
- Lim, S. H., Thomas, D. W., Coleman, S. L. and Stephens, P. 1996. T cell receptor Vβ repertoire of tumour-infiltrating lymphocytes in oral squamous-cell carcinoma. Cancer Immunology, Immunotherapy 42(1), pp. 69-70. (10.1007/s002620050253)
- Davies, L. C. et al. 2012. Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner. Stem Cells and Development 21(9), pp. 1478-1487. (10.1089/scd.2011.0434)
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
- Davies, L. C. et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19(6), pp. 819-830. (10.1089/scd.2009.0089)
- Simpson, R. M. L., Wells, A., Thomas, D. W., Stephens, P., Steadman, R. and Phillips, A. O. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176(3), pp. 1215-1228. (10.2353/ajpath.2010.090802)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
Ymchwil
Celloedd Propria-Progenitor Mucosal Llafar ar gyfer atgyweirio meinwe:
Mae clwyfau yn y geg yn gwella'n dda iawn o'u cymharu â chlwyfau croen arferol gan eu bod yn dangos ychydig neu ddim creithiau o gwbl. Rydym wedi bod yn ymchwilio i'r celloedd o feinweoedd meddal yn y geg ac wedi dangos eu bod yn wahanol i gelloedd croen ac mewn gwirionedd yn debycach i gelloedd y ffetws. Awgrymodd hyn y gall y celloedd o'r geg fod yn debycach i fôn-gelloedd mewn gwirionedd. Mae ein gwaith diweddar wedi nodi cell mor debyg i fôn-gelloedd yn y geg a all wneud gwahanol fathau o feinweoedd, yn gryf wrth is-reoleiddio'r system imiwnedd ac mae ganddynt eiddo gwrth-bacteriol. Felly, gall celloedd o'r fath fod yn ddefnyddiol i (a) helpu i atgyweirio/adfywio meinwe sydd wedi'i difrodi neu wedi'i heintio, (b) helpu i is-reoleiddio'r system imiwnedd yn ystod trawsblannu neu ar ôl i unigolion ddioddef o glefydau awtoimiwn a (c) bod yn ddefnyddiol wrth frwydro yn erbyn heintiau / canser. Yn bwysig, oherwydd bod meinwe sy'n cynnwys y celloedd llafar yn hawdd ei gyrchu a'i wella heb graith, gallai hyn fod y ffynhonnell ffafriol ar gyfer bôn-gelloedd ar gyfer therapi cleifion yn y dyfodol (patentau a ddyfarnwyd ac a ffeiliwyd; a ariennir gan yr MRC).
Gwella clwyfau cronig:
Rydym wedi bod â diddordeb hirdymor yn y sbectrwm o ymatebion clwyfau, gan gynnwys y rhai nad ydynt yn gwella (wlserau gwythiennol cronig, wlserau traed diabetig). Rydym eisoes wedi dangos, trwy ein dadansoddiadau in vitro , fod ymatebion moleciwlaidd a cellog ffibroblastau o glwyfau cronig yn gamweithredol. Mae hyn yn cynnwys ein harsylwadau bod ffibroblastau clwyfau cronig yn dangos senescence cynamserol sy'n effeithio ar eu gallu i yrru gwaith atgyweirio'r clwyf sy'n ddyledus i ddiffyg cynhyrchu sawl chemocinau allweddol. Rydym bellach yn datblygu'r straeniau cronig hyn yn llinellau celloedd clwyfau cronig wedi'u nodweddu'n dda a allai fod â'r potensial i gymryd lle rhywfaint o arbrofi anifeiliaid ar gyfer cyn-sgrinio deunyddiau yn y dyfodol a allai gael effeithiau buddiol i ddioddefwyr clwyfau cronig.
Olrhain bôn-gelloedd:
Un o'r prif rwystrau i gyfieithu mewn perthynas ag olrhain llinach/tynged bôn-gelloedd yw'r gallu i ddelweddu celloedd o fewn meinweoedd 3D mewn amser real. Yn draddodiadol, ceisiwyd defnyddio technegau delweddu golau sy'n seiliedig ar fflworoleuedd gyda galluoedd adrannol 3D megis confocal laser-sganio neu ficrosgopeg aml-ffoton i ddarparu delweddu meintiol, amser real o gelloedd. Fodd bynnag, mae dull o'r fath yn gyfyngedig oherwydd ffotoblethu ac effeithiau ffotowenwynig y label fflworochrome / moiety a ddefnyddir. Felly, rydym yn gweithio ar draws disgyblaethau (Ffiseg a Chemeg) i ddatblygu dulliau delweddu newydd, annistrywiol (PET ac MRI) i olrhain bôn-gelloedd a'u hepil mewn amser real mewn cleifion (a ariennir gan yr EPSRC ac Ymddiriedolaeth Wellcome).
Biobanking:
Trwy fy rôl fel Unigolyn Dynodedig HTA ym Mhrifysgol Caerdydd, rwyf ar hyn o bryd yn sefydlu Banc Bio Prifysgol Caerdydd i gydlynu mynediad ymchwil i samplau a data meinwe dynol ar draws ac allan gyda'r Brifysgol.
Cydweithio:
- Steve Paisey/Ian Fallis/Angelo Amoroso (Prifysgol Caerdydd, y DU) – Dulliau newydd ar gyfer olrhain bôn-gelloedd
- Aled Clayton/Helen Brown (Prifysgol Caerdydd, y DU) – Celloedd cynhenid llafar fel asiantau gwrth-bacteriol
- Rob Knight (UCLA, UDA) - Exosomau progenitor llafar fel asiant gwrth-greithio
- Hans von den Hoff (Canolfan Feddygol Prifysgol Radboud, Yr Iseldiroedd - Exosomau progenitor llafar fel asiant gwrth-greithio
Dyfarniadau
- Phil Stephens: Gwobr Teilyngdod Urdd Lifrai Cymru (2012)
- Rachel Howard-Jones: Gwobr Poster (Diwrnod Ymchwil Ôl-raddedig Prifysgol Caerdydd, 2009); Gwobr Llafar (Diwrnod Ymchwil Ôl-raddedig Prifysgol Caerdydd, 2011); Gwobr Uwch Colgate Cymdeithas Ymchwil Llafar a Deintyddol Prydain (2012); Gwobr Poster Cymdeithas Peirianneg Cell Meinwe (2014)
- Adam Glen: Gwobr Cyflwyniad Llafar y Gymdeithas Peirianneg Cell Meinwe (2013)
- Emma Board Davies: Gwobr Cyflwyniad Llafar (Cyfarfod Gwyddonol Blynyddol CITER, 2014)
- Lorena Hidalgo San Jose: Gwobr Cyflwyniad Llafar (Cyfarfod Gwyddonol Blynyddol CITER, 2015)
Peirianneg meinwe ac arbenigedd atgyweirio
- Bioleg celloedd progenitor llafar (datblygu / rheoli llinol, immunosuppression)
- Bioleg ffibroblast/matrics allgellog
- Datblygu systemau in vitro i ddisodli anifeiliaid mewn arbrofi
- Delweddu celloedd byw
- Bioassays gwella clwyfau
- Mynediad at ddeunydd clinigol o ffynonellau moesegol at ddibenion ymchwil
Addysgu
BDS deintyddol (Ecosystemau Llafar)
MSc Peirianneg Meinwe a Meddygaeth Adfywiol
MSc Mewnblanoleg
Bywgraffiad
Ar hyn o bryd mae'r Athro Phil Stephens yn Athro Bioleg Celloedd a Phennaeth Dros Dro yr Ysgol Deintyddiaeth, Coleg y Gwyddorau Biofeddygol a Bywyd, Prifysgol Caerdydd. Mae'n Ddeon Rhyngwladol y Brifysgol ar gyfer America. Symudodd i Brifysgol Caerdydd yn 1994 fel Ymchwilydd Ôl-ddoethurol ar ôl ennill gradd anrhydedd dosbarth cyntaf a PhD o Brifysgol Leeds. Wedi hynny sefydlodd y Grŵp Bioleg Clwyfau gyda chydweithiwr clinigol. Cyn hynny, roedd yn Is-Ddeon (Ymchwil) yn yr Ysgol Deintyddiaeth, yn gadeirydd Sefydliad Peirianneg a Thrwsio Meinwe Caerdydd ac yn Llywydd Cymdeithas Atgyweirio Meinwe Ewrop. Mae ei rôl ryngwladol bresennol yn canolbwyntio ar ddatblygu addysgu, recriwtio, ymchwil ac arloesi ledled y Brifysgol a chyfleoedd cyfnewid myfyrwyr/staff. Mae ei ddiddordebau ymchwil ym meysydd celloedd progenitor llafar, gwella clwyfau gwahaniaethol, heneiddio, peirianneg meinwe, systemau model amnewid anifeiliaid a delweddu cellog. Yn y meysydd hyn mae wedi rheoli prosiectau ymchwil (y Cyngor Ymchwil, Elusen a Diwydiant) gwerth cyfanswm o dros £4.5 miliwn, a gyhoeddwyd yn eang, wedi ffeilio patentau ac mae ei grŵp wedi ennill llawer o wobrau Cenedlaethol a Rhyngwladol. Yn allanol, mae'n gweithio'n agos gyda sefydliadau fel y Ganolfan Genedlaethol ar gyfer Disodli, Mireinio a Lleihau Anifeiliaid mewn Ymchwil ac adolygiadau ceisiadau grant a llawysgrifau ar gyfer nifer o gyllidwyr/cylchgronau cenedlaethol a rhyngwladol. Ef hefyd yw Arweinydd Academaidd Banc Bio Prifysgol Caerdydd sy'n cyflenwi biosamplau dynol ar gyfer ymchwil sy'n canolbwyntio ar wella iechyd pobl.
Aelodaethau proffesiynol
- Cymdeithas Atgyweirio Meinwe Ewropeaidd
Safleoedd academaidd blaenorol
2008 - Athro Bioleg Celloedd, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2013 - cyflwyno trwydded ymchwil HTA Unigol Dynodedig, Prifysgol Caerdydd
2015 - Arweinydd Academaidd presennol Banc Bio Prifysgol Caerdydd, Prifysgol Caerdydd
2024 - Deon Rhyngwladol ar gyfer yr Amerig, Prifysgol Caerdydd
2024 - Pennaeth Dros Dro yr Ysgol, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2016 - 2022 Deon Rhyngwladol, Coleg y Gwyddorau Biofeddygol a Bywyd, Prifysgol Caerdydd
2017 - 2019 Llywydd Cymdeithas Atgyweirio Meinwe Ewrop
2015 - 2016 Arweinydd Thema Ymchwil ar gyfer Biosystemau Integreiddiol, Coleg y Gwyddorau Biofeddygol a Bywyd (BLS), Prifysgol Caerdydd
2010 - 2015 Is-Ddeon (Ymchwil), Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2010 - 2015 Pennaeth Sefydliad Peirianneg a Thrwsio Meinwe Caerdydd (CITER)
2008 - 2010 Pennaeth Peirianneg Meinwe a Deintyddiaeth Atgyweiriol, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2004 - 2008 Darllenydd mewn Bioleg Celloedd, Grŵp Bioleg Clwyfau, Adran Llawfeddygaeth Lafar, Meddygaeth a Patholeg, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2002 - 2004 Uwch Ddarlithydd mewn Bioleg Celloedd, Adran Llawfeddygaeth Lafar, Meddygaeth a Patholeg, Ysgol Ddeintyddol, UWCM, Caerdydd
1998 - 2002 Darlithydd mewn Bioleg Celloedd, Dept. Llawfeddygaeth lafar, Meddygaeth a Patholeg, Ysgol Ddeintyddol, UWCM, Caerdydd
Rhagfyr - Rhagfyr 1997 Secondiad i'r Labordai Hematopoiesis Moleciwlaidd yr Athro Corey Largman, UCSF, San Francisco, UDA i ymchwilio i rôl genynnau homeobox newydd mewn iacháu clwyfau di-ofn
1994 - 1998 Cymrawd Ymchwil Ôl-ddoethurol, Adran Llawfeddygaeth Lafar, Meddygaeth a Patholeg, Ysgol Ddeintyddol, UWCM, Caerdydd
Meysydd goruchwyliaeth
- Celloedd progenitor llafar fesiglau allgellog bach fel asiantau gwrth-greithio a gwrthficrobaidd
- Datblygu asiantau olrhain celloedd tymor hir (PET, MRI)
Contact Details
Themâu ymchwil
Arbenigeddau
- Bioleg Celloedd
- Meddygaeth adfywiol
- Celloedd bonyn
- Peirianneg meinwe