![Phil Stephens BSc (Hons) PhD](https://profiles-cardiff.imgix.net/attachments/10048?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Phil Stephens
(e/fe)
BSc (Hons) PhD
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Phil Stephens
Cadair
Trosolwg
Dirprwy Bennaeth yr Ysgol: Pobl a Diwylliant, Deon Rhyngwladol Americas, Athro Bioleg Celloedd, Trwydded Ymchwil HTA Unigolyn dynodedig ac Arweinydd Academaidd ar gyfer Biobanc Prifysgol Caerdydd.
Cyhoeddiad
2026
- Davies-Jones, J. A. et al., 2026. Unravelling nanoscale chemistries in complex biological systems using photoinduced force microscopy (PiFM). Faraday Discussions 265 , pp.56-75. (10.1039/d5fd00141b)
- Asadpour, A. et al., 2026. Neural crest-derived stem cell secretomes and extracellular vesicles disrupt glioblastoma through dual-pathway inflammatory rebalancing. Stem Cell Reviews and Reports 22 , pp.2528-2548. (10.1007/s12015-026-11133-5)
- Singh, T. et al., 2026. Human induced pluripotent stem cell-derived microglia with 1q21.1 deletion and duplication exhibit aberrant inflammatory response. Genes & diseases 13 (4) 101923. (10.1016/j.gendis.2025.101923)
- Kutnyanszky, M. , Stephens, P. and Mead, B. 2026. Small extracellular vesicles promote cell survival and neuritogenesis in vitro in a manner dependent on dosage and cell of origin. Scientific Reports 16 25331. (10.1038/s41598-026-53763-2)
2025
- Elfar, M. Y. et al. 2025. Antibiotic carry over is a confounding factor for cell-based antimicrobial research applications. Scientific Reports 15 (1) 28310. (10.1038/s41598-025-14186-7)
2023
- Wang, Z. et al., 2023. Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing. Stem Cell Research and Therapy 14 (1) 203. (10.1186/s13287-023-03423-3)
- Lohana, P. et al., 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12 (7) 1374. (10.3390/antiox12071374)
2022
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11 (8), pp.861-875. (10.1093/stcltm/szac037)
2021
- Brown, H. , Clayton, A. and Stephens, P. 2021. The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges. Wound Repair and Regeneration 29 (6), pp.864-880. (10.1111/wrr.12949)
- Stephens, N. and Stephens, P. 2021. Interdisciplinary projects as an expert-network: analysing team work across biological and physical sciences. Science and Technology Studies 34 (4), pp.56-73. (10.23987/sts.87339)
2020
- Yang, Y. et al., 2020. Three-dimensional culture of oral progenitor cells: effects on small extracellular vesicles production and proliferative function. Journal of Oral Pathology and Medicine 49 (4), pp.342-349. (10.1111/jop.12981)
2018
- Masia, F. et al. 2018. Label-free quantitative chemical imaging and classification analysis of adipogenesis using mouse embryonic stem cells. Journal of Biophotonics 11 (7) e201700219. (10.1002/jbio.201700219)
- Caley, M. et al. 2018. Development and characterisation of a human chronic skin wound cell line - towards an alternative for animal experimentation. International Journal of Molecular Sciences 19 (4) 1001. (10.3390/ijms19041001)
- Hidalgo San Jose, L. et al. 2018. Microfluidic encapsulation supports stem cell viability, proliferation and neuronal differentiation. Tissue Engineering Part C Methods 24 (3), pp.158-170. (10.1089/ten.TEC.2017.0368)
2016
- Locke, M. , Davies, L. C. and Stephens, P. 2016. Oral mucosal progenitor cell clones resist In Vitro myogenic differentiation. Archives of Oral Biology 70 , pp.100-110. (10.1016/j.archoralbio.2016.06.013)
- Howard-Jones, R. A. et al. 2016. Integration-free reprogramming of lamina propria progenitor cells. Journal of Dental Research 95 (8), pp.882-888. (10.1177/0022034516637579)
- Perkins, B. L. et al., 2016. The life science exchange: A case study of a sectoral and sub-sectoral knowledge exchange programme. Health Research Policy and Systems 14 32. (10.1186/s12961-016-0105-4)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11 (4) e0152023. (10.1371/journal.pone.0152023)
2015
- Roper, J. A. et al., 2015. Ultrasonic stimulation of mouse skin reverses the healing delays in diabetes and aging by activation of Rac1. Journal of Investigative Dermatology 135 (11), pp.2842-2851. (10.1038/jid.2015.224)
- Board-Davies, E. et al., 2015. Oral mucosal lamina propria-progenitor cells exert antibacterial properties via the secretion of osteoprotegerin and haptoglobin. Stem Cells Translational Medicine 4 (11), pp.1283-1293. (10.5966/sctm.2015-0043)
2014
- Stephens, P. and Davies, L. C. 2014. Oral mucosal progenitor cells. In: Vishwakarma, A. et al., Stem Cell Biology and Tissue Engineering in Dental Sciences. Academic Press. , pp.297-306. (10.1016/B978-0-12-397157-9.00025-4)
- Peake, M. A. et al. 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22 (3), pp.399-405. (10.1111/wrr.12170)
- McInnes, R. L. et al., 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22 (1), pp.58-69. (10.1111/wrr.12133)
2013
- Masia, F. et al. 2013. Quantitative chemical imaging and unsupervised analysis using hyperspectral coherent anti-Stokes Raman scattering microscopy. Analytical Chemistry 85 (22), pp.10820-10828. (10.1021/ac402303g)
- Stephens, P. , Caley, M. and Peake, M. 2013. Alternatives for animal wound model systems. In: Gourdie, R. G. and Myers, T. A. eds. Wound Regeneration and Repair. Vol. 1037, Methods in Molecular Biology Springer. , pp.177-201. (10.1007/978-1-62703-505-7_10)
2012
- Davies, L. C. et al. 2012. Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner. Stem Cells and Development 21 (9), pp.1478-1487. (10.1089/scd.2011.0434)
- Wagstaffe, S. J. et al., 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84 (14), pp.5876-5884. (10.1021/ac203403d)
- Wildeboer, D. et al., 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31 (9), pp.2183-2189. (10.1007/s10096-012-1553-6)
2011
- Stephens, P. 2011. Dysfunctional wound healing in chronic wounds. In: Farrar, D. ed. Advanced Wound Repair Therapies. Woodhead Publishing. , pp.3-38. (10.1533/9780857093301.1.3)
2010
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89 (12), pp.1407-1413. (10.1177/0022034510377796)
- Hardwicke, J. et al. 2010. Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7 (3), pp.699-707. (10.1021/mp9002656)
- Simpson, R. M. L. et al. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176 (3), pp.1215-1228. (10.2353/ajpath.2010.090802)
- Davies, L. C. et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19 (6), pp.819-830. (10.1089/scd.2009.0089)
- Stephens, P. 2010. Development of a cell-based diabetic wound assay. ATLA Alternatives to Laboratory Animals 38 (SUPPL.), pp.45-48.
2009
- Simpson, R. M. L. et al. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175 (5), pp.1915-1928. (10.2353/ajpath.2009.090045)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88 (10), pp.916-921. (10.1177/0022034509342979)
- Iversen, A. et al., 2009. A proviral role for CpG in cytomegalovirus infection. Journal of Immunology 182 (9), pp.5672-5681. (10.4049/jimmunol.0801268)
- Simpson, R. M. et al. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90 (2), pp.A128-A129.
- Cook, H. et al., 2009. Phenotypic differences in wound healing responses are reflected by differences in ECM reorganisation and MMP-2 activation. Journal of Gastroenterology and Hepatology 24 , pp.A88-A88. (10.1046/j.1365-2613.2000.0145k.x)
- Enoch, S. and Stephens, P. 2009. Scarless healing: Oral mucosa as a scientific model. Wounds UK 5 (1), pp.42-48.
2008
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128 (10), pp.2526-2540. (10.1038/jid.2008.114)
- Hardwicke, J. et al. 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130 (3), pp.275-283. (10.1016/j.jconrel.2008.07.023)
- Meran, S. et al. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283 (10), pp.6530-6545. (10.1074/jbc.M704819200)
- Enoch, S. et al., 2008. The oral mucosa: A model of wound healing with reduced scarring. Oral Surgery 1 , pp.11-21. (10.1111/j.1752-248x.2007.00005.x)
- Peake, M. A. et al. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16 (6), pp.A71. (10.1111/j.1524-475X.2008.00424.x)
- Mantripragada, K. K. et al. 2008. Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals. Genes Chromosomes and Cancer 47 (3), pp.238-246. (10.1002/gcc.20525)
- Meran, S. et al. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16 (2), pp.A12. (10.1111/j.1524-475X.2008.00371.x)
2007
- Meran, S. et al. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282 (35), pp.25687-25697. (10.1074/jbc.M700773200)
- Davies, C. E. et al., 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15 (1), pp.17-22. (10.1111/j.1524-475X.2006.00180.x)
- Andersen, A. et al., 2007. Bacterial profiling using skin grafting, standard culture and molecular bacteriological methods. Journal of Wound Care 16 (4), pp.171-175.
- Lygoe, K. A. et al., 2007. Role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation. Biology of the Cell 99 (11), pp.601-614. (10.1042/BC20070008)
- Stephens, P. and Genever, P. 2007. Non-epithelial oral mucosal progenitor cell populations. Oral Diseases 13 (1), pp.1-10. (10.1111/j.1601-0825.2006.01314.x)
2004
- Davies, C. E. et al., 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42 (8), pp.3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
- Moseley, R. et al. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12 (4), pp.419-429. (10.1111/j.1067-1927.2004.12406.x)
- Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117 (15), pp.3389-3403. (10.1242/jcs.01188)
- Enoch, S. et al., 2004. Identifying the molecular and genetic basis for non-healing wounds, scarless healing and scarring: study of human fibroblasts. British Journal of Surgery 91 (S1), pp.82-82.
- Moseley, R. et al. 2004. Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?. British Journal of Dermatology 150 (3), pp.401-413. (10.1111/j.1365-2133.2004.05845.x)
2003
- Hill, K. E. et al. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52 (4), pp.365-369. (10.1099/jmm.0.05030-0)
- Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148 (3), pp.456-466. (10.1046/j.1365-2133.2003.05232.x)
- Stephens, P. et al. 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283 (1), pp.22-35. (10.1016/S0014-4827(02)00021-6)
- White, P. et al., 2003. Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. Journal Of Investigative Dermatology 120 (1), pp.135-144. (10.1046/j.1523-1747.2003.12015.x)
2002
- Hill, K. E. et al. 2002. Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51 (11), pp.949-957.
- Stephens, P. and Thomas, D. W. 2002. The cellular proliferative phase of the wound repair process. Journal of Wound Care 11 (7), pp.253-261. (10.12968/jowc.2002.11.7.26421)
- Wall, I. B. et al., 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10 (6), pp.346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
2001
- Stephens, P. et al. 2001. Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity. British Journal Of Dermatology 144 (2), pp.229-237. (10.1046/j.1365-2133.2001.04006.x)
- Stephens, P. et al. 2001. Phenotypic variation in the production of bioactive hepatocyte growth factor/scatter factor by oral mucosal and skin fibroblasts. Wound Repair and Regeneration 9 (1), pp.34-43. (10.1046/j.1524-475x.2001.00034.x)
- Davies, C. E. et al., 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9 (5), pp.332-340. (10.1046/j.1524-475x.2001.00332.x)
2000
- Cook, H. et al., 2000. Defective Extracellular Matrix Reorganization by Chronic Wound Fibroblasts is Associated with Alterations in TIMP-1, TIMP-2, and MMP-2 Activity. Journal of Investigative Dermatology 115 (2), pp.225-233. (10.1046/j.1523-1747.2000.00044.x)
- Thomas, D. W. et al. 2000. Randomized clinical trial of the effect of semi-occlusive dressings on the microflora and clinical outcome of acute facial wounds. Wound Repair and Regeneration 8 (4), pp.258-263. (10.1046/j.1524-475x.2000.00258.x)
1998
- Stephens, M. et al., 1998. Molecular characterisation of tumour infiltrating lymphocytes in oral squamous cell carcinoma. Cancer Immunology, Immunotherapy 46 (1), pp.34-40. (10.1007/s002620050457)
1997
- al-Khateeb, T. et al., 1997. An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model. Journal of Periodontology 68 (11), pp.1063-1069. (10.1902/jop.1997.68.11.1063)
- Lim, S. H. et al., 1997. Molecular analysis of T cell receptor beta variability in a patient with orofacial granulomatosis. Gut 40 (5), pp.683-686. (10.1136/gut.40.5.683)
- Stephens, P. et al. 1997. Integrin receptor involvement in actin cable formation in an in vitro model of events associated with wound contraction. The International Journal of Biochemistry & Cell Biology 29 (1), pp.121-128. (10.1016/S1357-2725(96)00123-9)
- Thomas, D. W. et al. 1997. T-cell receptor Vbeta usage by lesional lymphocytes in oral lichen planus. Journal of Oral Pathology & Medicine 26 (3), pp.105-109. (10.1111/j.1600-0714.1997.tb00031.x)
1996
- Stephens, P. et al. 1996. A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction. Journal of Dental Research 75 (6), pp.1358-1364. (10.1177/00220345960750060601)
- Lim, S. H. et al., 1996. T cell receptor Vβ repertoire of tumour-infiltrating lymphocytes in oral squamous-cell carcinoma. Cancer Immunology, Immunotherapy 42 (1), pp.69-70. (10.1007/s002620050253)
- Stephens, P. et al. 1996. An investigation of the interaction between alcohol and fibroblasts in wound healing. International Journal of Oral and Maxillofacial Surgery 25 (2), pp.161-164. (10.1016/S0901-5027(96)80065-8)
Adrannau llyfrau
- Stephens, P. and Davies, L. C. 2014. Oral mucosal progenitor cells. In: Vishwakarma, A. et al., Stem Cell Biology and Tissue Engineering in Dental Sciences. Academic Press. , pp.297-306. (10.1016/B978-0-12-397157-9.00025-4)
- Stephens, P. , Caley, M. and Peake, M. 2013. Alternatives for animal wound model systems. In: Gourdie, R. G. and Myers, T. A. eds. Wound Regeneration and Repair. Vol. 1037, Methods in Molecular Biology Springer. , pp.177-201. (10.1007/978-1-62703-505-7_10)
- Stephens, P. 2011. Dysfunctional wound healing in chronic wounds. In: Farrar, D. ed. Advanced Wound Repair Therapies. Woodhead Publishing. , pp.3-38. (10.1533/9780857093301.1.3)
Erthyglau
- Davies-Jones, J. A. et al., 2026. Unravelling nanoscale chemistries in complex biological systems using photoinduced force microscopy (PiFM). Faraday Discussions 265 , pp.56-75. (10.1039/d5fd00141b)
- Asadpour, A. et al., 2026. Neural crest-derived stem cell secretomes and extracellular vesicles disrupt glioblastoma through dual-pathway inflammatory rebalancing. Stem Cell Reviews and Reports 22 , pp.2528-2548. (10.1007/s12015-026-11133-5)
- Singh, T. et al., 2026. Human induced pluripotent stem cell-derived microglia with 1q21.1 deletion and duplication exhibit aberrant inflammatory response. Genes & diseases 13 (4) 101923. (10.1016/j.gendis.2025.101923)
- Kutnyanszky, M. , Stephens, P. and Mead, B. 2026. Small extracellular vesicles promote cell survival and neuritogenesis in vitro in a manner dependent on dosage and cell of origin. Scientific Reports 16 25331. (10.1038/s41598-026-53763-2)
- Elfar, M. Y. et al. 2025. Antibiotic carry over is a confounding factor for cell-based antimicrobial research applications. Scientific Reports 15 (1) 28310. (10.1038/s41598-025-14186-7)
- Wang, Z. et al., 2023. Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing. Stem Cell Research and Therapy 14 (1) 203. (10.1186/s13287-023-03423-3)
- Lohana, P. et al., 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12 (7) 1374. (10.3390/antiox12071374)
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11 (8), pp.861-875. (10.1093/stcltm/szac037)
- Brown, H. , Clayton, A. and Stephens, P. 2021. The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges. Wound Repair and Regeneration 29 (6), pp.864-880. (10.1111/wrr.12949)
- Stephens, N. and Stephens, P. 2021. Interdisciplinary projects as an expert-network: analysing team work across biological and physical sciences. Science and Technology Studies 34 (4), pp.56-73. (10.23987/sts.87339)
- Yang, Y. et al., 2020. Three-dimensional culture of oral progenitor cells: effects on small extracellular vesicles production and proliferative function. Journal of Oral Pathology and Medicine 49 (4), pp.342-349. (10.1111/jop.12981)
- Masia, F. et al. 2018. Label-free quantitative chemical imaging and classification analysis of adipogenesis using mouse embryonic stem cells. Journal of Biophotonics 11 (7) e201700219. (10.1002/jbio.201700219)
- Caley, M. et al. 2018. Development and characterisation of a human chronic skin wound cell line - towards an alternative for animal experimentation. International Journal of Molecular Sciences 19 (4) 1001. (10.3390/ijms19041001)
- Hidalgo San Jose, L. et al. 2018. Microfluidic encapsulation supports stem cell viability, proliferation and neuronal differentiation. Tissue Engineering Part C Methods 24 (3), pp.158-170. (10.1089/ten.TEC.2017.0368)
- Locke, M. , Davies, L. C. and Stephens, P. 2016. Oral mucosal progenitor cell clones resist In Vitro myogenic differentiation. Archives of Oral Biology 70 , pp.100-110. (10.1016/j.archoralbio.2016.06.013)
- Howard-Jones, R. A. et al. 2016. Integration-free reprogramming of lamina propria progenitor cells. Journal of Dental Research 95 (8), pp.882-888. (10.1177/0022034516637579)
- Perkins, B. L. et al., 2016. The life science exchange: A case study of a sectoral and sub-sectoral knowledge exchange programme. Health Research Policy and Systems 14 32. (10.1186/s12961-016-0105-4)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11 (4) e0152023. (10.1371/journal.pone.0152023)
- Roper, J. A. et al., 2015. Ultrasonic stimulation of mouse skin reverses the healing delays in diabetes and aging by activation of Rac1. Journal of Investigative Dermatology 135 (11), pp.2842-2851. (10.1038/jid.2015.224)
- Board-Davies, E. et al., 2015. Oral mucosal lamina propria-progenitor cells exert antibacterial properties via the secretion of osteoprotegerin and haptoglobin. Stem Cells Translational Medicine 4 (11), pp.1283-1293. (10.5966/sctm.2015-0043)
- Peake, M. A. et al. 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22 (3), pp.399-405. (10.1111/wrr.12170)
- McInnes, R. L. et al., 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22 (1), pp.58-69. (10.1111/wrr.12133)
- Masia, F. et al. 2013. Quantitative chemical imaging and unsupervised analysis using hyperspectral coherent anti-Stokes Raman scattering microscopy. Analytical Chemistry 85 (22), pp.10820-10828. (10.1021/ac402303g)
- Davies, L. C. et al. 2012. Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner. Stem Cells and Development 21 (9), pp.1478-1487. (10.1089/scd.2011.0434)
- Wagstaffe, S. J. et al., 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84 (14), pp.5876-5884. (10.1021/ac203403d)
- Wildeboer, D. et al., 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31 (9), pp.2183-2189. (10.1007/s10096-012-1553-6)
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89 (12), pp.1407-1413. (10.1177/0022034510377796)
- Hardwicke, J. et al. 2010. Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7 (3), pp.699-707. (10.1021/mp9002656)
- Simpson, R. M. L. et al. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176 (3), pp.1215-1228. (10.2353/ajpath.2010.090802)
- Davies, L. C. et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19 (6), pp.819-830. (10.1089/scd.2009.0089)
- Stephens, P. 2010. Development of a cell-based diabetic wound assay. ATLA Alternatives to Laboratory Animals 38 (SUPPL.), pp.45-48.
- Simpson, R. M. L. et al. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175 (5), pp.1915-1928. (10.2353/ajpath.2009.090045)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88 (10), pp.916-921. (10.1177/0022034509342979)
- Iversen, A. et al., 2009. A proviral role for CpG in cytomegalovirus infection. Journal of Immunology 182 (9), pp.5672-5681. (10.4049/jimmunol.0801268)
- Simpson, R. M. et al. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90 (2), pp.A128-A129.
- Cook, H. et al., 2009. Phenotypic differences in wound healing responses are reflected by differences in ECM reorganisation and MMP-2 activation. Journal of Gastroenterology and Hepatology 24 , pp.A88-A88. (10.1046/j.1365-2613.2000.0145k.x)
- Enoch, S. and Stephens, P. 2009. Scarless healing: Oral mucosa as a scientific model. Wounds UK 5 (1), pp.42-48.
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128 (10), pp.2526-2540. (10.1038/jid.2008.114)
- Hardwicke, J. et al. 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130 (3), pp.275-283. (10.1016/j.jconrel.2008.07.023)
- Meran, S. et al. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283 (10), pp.6530-6545. (10.1074/jbc.M704819200)
- Enoch, S. et al., 2008. The oral mucosa: A model of wound healing with reduced scarring. Oral Surgery 1 , pp.11-21. (10.1111/j.1752-248x.2007.00005.x)
- Peake, M. A. et al. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16 (6), pp.A71. (10.1111/j.1524-475X.2008.00424.x)
- Mantripragada, K. K. et al. 2008. Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals. Genes Chromosomes and Cancer 47 (3), pp.238-246. (10.1002/gcc.20525)
- Meran, S. et al. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16 (2), pp.A12. (10.1111/j.1524-475X.2008.00371.x)
- Meran, S. et al. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282 (35), pp.25687-25697. (10.1074/jbc.M700773200)
- Davies, C. E. et al., 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15 (1), pp.17-22. (10.1111/j.1524-475X.2006.00180.x)
- Andersen, A. et al., 2007. Bacterial profiling using skin grafting, standard culture and molecular bacteriological methods. Journal of Wound Care 16 (4), pp.171-175.
- Lygoe, K. A. et al., 2007. Role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation. Biology of the Cell 99 (11), pp.601-614. (10.1042/BC20070008)
- Stephens, P. and Genever, P. 2007. Non-epithelial oral mucosal progenitor cell populations. Oral Diseases 13 (1), pp.1-10. (10.1111/j.1601-0825.2006.01314.x)
- Davies, C. E. et al., 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42 (8), pp.3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
- Moseley, R. et al. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12 (4), pp.419-429. (10.1111/j.1067-1927.2004.12406.x)
- Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117 (15), pp.3389-3403. (10.1242/jcs.01188)
- Enoch, S. et al., 2004. Identifying the molecular and genetic basis for non-healing wounds, scarless healing and scarring: study of human fibroblasts. British Journal of Surgery 91 (S1), pp.82-82.
- Moseley, R. et al. 2004. Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?. British Journal of Dermatology 150 (3), pp.401-413. (10.1111/j.1365-2133.2004.05845.x)
- Hill, K. E. et al. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52 (4), pp.365-369. (10.1099/jmm.0.05030-0)
- Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148 (3), pp.456-466. (10.1046/j.1365-2133.2003.05232.x)
- Stephens, P. et al. 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283 (1), pp.22-35. (10.1016/S0014-4827(02)00021-6)
- White, P. et al., 2003. Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. Journal Of Investigative Dermatology 120 (1), pp.135-144. (10.1046/j.1523-1747.2003.12015.x)
- Hill, K. E. et al. 2002. Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51 (11), pp.949-957.
- Stephens, P. and Thomas, D. W. 2002. The cellular proliferative phase of the wound repair process. Journal of Wound Care 11 (7), pp.253-261. (10.12968/jowc.2002.11.7.26421)
- Wall, I. B. et al., 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10 (6), pp.346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
- Stephens, P. et al. 2001. Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity. British Journal Of Dermatology 144 (2), pp.229-237. (10.1046/j.1365-2133.2001.04006.x)
- Stephens, P. et al. 2001. Phenotypic variation in the production of bioactive hepatocyte growth factor/scatter factor by oral mucosal and skin fibroblasts. Wound Repair and Regeneration 9 (1), pp.34-43. (10.1046/j.1524-475x.2001.00034.x)
- Davies, C. E. et al., 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9 (5), pp.332-340. (10.1046/j.1524-475x.2001.00332.x)
- Cook, H. et al., 2000. Defective Extracellular Matrix Reorganization by Chronic Wound Fibroblasts is Associated with Alterations in TIMP-1, TIMP-2, and MMP-2 Activity. Journal of Investigative Dermatology 115 (2), pp.225-233. (10.1046/j.1523-1747.2000.00044.x)
- Thomas, D. W. et al. 2000. Randomized clinical trial of the effect of semi-occlusive dressings on the microflora and clinical outcome of acute facial wounds. Wound Repair and Regeneration 8 (4), pp.258-263. (10.1046/j.1524-475x.2000.00258.x)
- Stephens, M. et al., 1998. Molecular characterisation of tumour infiltrating lymphocytes in oral squamous cell carcinoma. Cancer Immunology, Immunotherapy 46 (1), pp.34-40. (10.1007/s002620050457)
- al-Khateeb, T. et al., 1997. An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model. Journal of Periodontology 68 (11), pp.1063-1069. (10.1902/jop.1997.68.11.1063)
- Lim, S. H. et al., 1997. Molecular analysis of T cell receptor beta variability in a patient with orofacial granulomatosis. Gut 40 (5), pp.683-686. (10.1136/gut.40.5.683)
- Stephens, P. et al. 1997. Integrin receptor involvement in actin cable formation in an in vitro model of events associated with wound contraction. The International Journal of Biochemistry & Cell Biology 29 (1), pp.121-128. (10.1016/S1357-2725(96)00123-9)
- Thomas, D. W. et al. 1997. T-cell receptor Vbeta usage by lesional lymphocytes in oral lichen planus. Journal of Oral Pathology & Medicine 26 (3), pp.105-109. (10.1111/j.1600-0714.1997.tb00031.x)
- Stephens, P. et al. 1996. A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction. Journal of Dental Research 75 (6), pp.1358-1364. (10.1177/00220345960750060601)
- Lim, S. H. et al., 1996. T cell receptor Vβ repertoire of tumour-infiltrating lymphocytes in oral squamous-cell carcinoma. Cancer Immunology, Immunotherapy 42 (1), pp.69-70. (10.1007/s002620050253)
- Stephens, P. et al. 1996. An investigation of the interaction between alcohol and fibroblasts in wound healing. International Journal of Oral and Maxillofacial Surgery 25 (2), pp.161-164. (10.1016/S0901-5027(96)80065-8)
Ymchwil
Celloedd Propria-Progenitor Mucosal Llafar ar gyfer atgyweirio meinwe:
Mae clwyfau yn y geg yn gwella'n dda iawn o'u cymharu â chlwyfau croen arferol gan eu bod yn dangos ychydig neu ddim creithiau o gwbl. Rydym wedi bod yn ymchwilio i'r celloedd o feinweoedd meddal yn y geg ac wedi dangos eu bod yn wahanol i gelloedd croen ac mewn gwirionedd yn debycach i gelloedd y ffetws. Awgrymodd hyn y gall y celloedd o'r geg fod yn debycach i fôn-gelloedd mewn gwirionedd. Mae ein gwaith diweddar wedi nodi cell mor debyg i fôn-gelloedd yn y geg a all wneud gwahanol fathau o feinweoedd, yn gryf wrth is-reoleiddio'r system imiwnedd ac mae ganddynt eiddo gwrth-bacteriol. Felly, gall celloedd o'r fath fod yn ddefnyddiol i (a) helpu i atgyweirio/adfywio meinwe sydd wedi'i difrodi neu wedi'i heintio, (b) helpu i is-reoleiddio'r system imiwnedd yn ystod trawsblannu neu ar ôl i unigolion ddioddef o glefydau awtoimiwn a (c) bod yn ddefnyddiol wrth frwydro yn erbyn heintiau / canser. Yn bwysig, oherwydd bod meinwe sy'n cynnwys y celloedd llafar yn hawdd ei gyrchu a'i wella heb graith, gallai hyn fod y ffynhonnell ffafriol ar gyfer bôn-gelloedd ar gyfer therapi cleifion yn y dyfodol (patentau a ddyfarnwyd ac a ffeiliwyd; a ariennir gan yr MRC).
Gwella clwyfau cronig:
Rydym wedi bod â diddordeb hirdymor yn y sbectrwm o ymatebion clwyfau, gan gynnwys y rhai nad ydynt yn gwella (wlserau gwythiennol cronig, wlserau traed diabetig). Rydym eisoes wedi dangos, trwy ein dadansoddiadau in vitro , fod ymatebion moleciwlaidd a cellog ffibroblastau o glwyfau cronig yn gamweithredol. Mae hyn yn cynnwys ein harsylwadau bod ffibroblastau clwyfau cronig yn dangos senescence cynamserol sy'n effeithio ar eu gallu i yrru gwaith atgyweirio'r clwyf sy'n ddyledus i ddiffyg cynhyrchu sawl chemocinau allweddol. Rydym bellach yn datblygu'r straeniau cronig hyn yn llinellau celloedd clwyfau cronig wedi'u nodweddu'n dda a allai fod â'r potensial i gymryd lle rhywfaint o arbrofi anifeiliaid ar gyfer cyn-sgrinio deunyddiau yn y dyfodol a allai gael effeithiau buddiol i ddioddefwyr clwyfau cronig.
Olrhain bôn-gelloedd:
Un o'r prif rwystrau i gyfieithu mewn perthynas ag olrhain llinach/tynged bôn-gelloedd yw'r gallu i ddelweddu celloedd o fewn meinweoedd 3D mewn amser real. Yn draddodiadol, ceisiwyd defnyddio technegau delweddu golau sy'n seiliedig ar fflworoleuedd gyda galluoedd adrannol 3D megis confocal laser-sganio neu ficrosgopeg aml-ffoton i ddarparu delweddu meintiol, amser real o gelloedd. Fodd bynnag, mae dull o'r fath yn gyfyngedig oherwydd ffotoblethu ac effeithiau ffotowenwynig y label fflworochrome / moiety a ddefnyddir. Felly, rydym yn gweithio ar draws disgyblaethau (Ffiseg a Chemeg) i ddatblygu dulliau delweddu newydd, annistrywiol (PET ac MRI) i olrhain bôn-gelloedd a'u hepil mewn amser real mewn cleifion (a ariennir gan yr EPSRC ac Ymddiriedolaeth Wellcome).
Biobanking:
Trwy fy rôl fel Unigolyn Dynodedig HTA ym Mhrifysgol Caerdydd, rwyf ar hyn o bryd yn sefydlu Banc Bio Prifysgol Caerdydd i gydlynu mynediad ymchwil i samplau a data meinwe dynol ar draws ac allan gyda'r Brifysgol.
Cydweithio:
- Steve Paisey/Ian Fallis/Angelo Amoroso (Prifysgol Caerdydd, y DU) – Dulliau newydd ar gyfer olrhain bôn-gelloedd
- Aled Clayton/Helen Brown (Prifysgol Caerdydd, y DU) – Celloedd cynhenid llafar fel asiantau gwrth-bacteriol
- Rob Knight (UCLA, UDA) - Exosomau progenitor llafar fel asiant gwrth-greithio
- Hans von den Hoff (Canolfan Feddygol Prifysgol Radboud, Yr Iseldiroedd - Exosomau progenitor llafar fel asiant gwrth-greithio
Dyfarniadau
- Phil Stephens: Gwobr Teilyngdod Urdd Lifrai Cymru (2012)
- Rachel Howard-Jones: Gwobr Poster (Diwrnod Ymchwil Ôl-raddedig Prifysgol Caerdydd, 2009); Gwobr Llafar (Diwrnod Ymchwil Ôl-raddedig Prifysgol Caerdydd, 2011); Gwobr Uwch Colgate Cymdeithas Ymchwil Llafar a Deintyddol Prydain (2012); Gwobr Poster Cymdeithas Peirianneg Cell Meinwe (2014)
- Adam Glen: Gwobr Cyflwyniad Llafar y Gymdeithas Peirianneg Cell Meinwe (2013)
- Emma Board Davies: Gwobr Cyflwyniad Llafar (Cyfarfod Gwyddonol Blynyddol CITER, 2014)
- Lorena Hidalgo San Jose: Gwobr Cyflwyniad Llafar (Cyfarfod Gwyddonol Blynyddol CITER, 2015)
Peirianneg meinwe ac arbenigedd atgyweirio
- Bioleg celloedd progenitor llafar (datblygu / rheoli llinol, immunosuppression)
- Bioleg ffibroblast/matrics allgellog
- Datblygu systemau in vitro i ddisodli anifeiliaid mewn arbrofi
- Delweddu celloedd byw
- Bioassays gwella clwyfau
- Mynediad at ddeunydd clinigol o ffynonellau moesegol at ddibenion ymchwil
Addysgu
BDS Deintyddol
MSc Peirianneg Meinwe a Meddygaeth Adfywiol
MSc Mewnblaniad
Bywgraffiad
Ar hyn o bryd mae'r Athro Phil Stephens yn Athro Bioleg Celloedd ac yn Ddirprwy Bennaeth yr Ysgol Deintyddiaeth, Coleg y Gwyddorau Biofeddygol a Bywyd, Prifysgol Caerdydd. Mae'n Ddeon Rhyngwladol y Brifysgol ar gyfer Americas. Symudodd i Brifysgol Caerdydd yn 1994 fel Ymchwilydd Ôl-ddoethurol ar ôl ennill gradd anrhydedd dosbarth cyntaf a PhD o Brifysgol Leeds. Wedi hynny sefydlodd y Grŵp Bioleg Clwyfau gyda chydweithiwr clinigol. Cyn hynny, roedd yn Is-ddeon (Ymchwil) yn yr Ysgol Deintyddiaeth, yn gadeirydd Sefydliad Peirianneg a Thrwsio Meinweoedd Caerdydd ac yn Llywydd Cymdeithas Atgyweirio Meinweoedd Ewrop. Mae ei rôl ryngwladol bresennol yn canolbwyntio ar ddatblygu addysgu, recriwtio, ymchwil ac arloesi a chyfleoedd cyfnewid myfyrwyr/staff ledled y Brifysgol. Mae ei ddiddordebau ymchwil ym meysydd celloedd rhagflaenol y geg, iachau clwyfau gwahaniaethol, heneiddio, peirianneg meinweoedd, systemau model amnewid anifeiliaid a delweddu cellog. O fewn y meysydd hyn mae wedi rheoli prosiectau ymchwil (Cyngor Ymchwil, Elusen a Diwydiant) sy'n dod i gyfanswm o dros £4.5 miliwn, wedi'u cyhoeddi'n eang, wedi ffeilio patentau ac mae ei grŵp wedi ennill nifer o wobrau Cenedlaethol a Rhyngwladol. Yn allanol mae'n gweithio'n agos gyda sefydliadau fel y Ganolfan Genedlaethol ar gyfer Amnewid, Mireinio a Lleihau Anifeiliaid mewn Ymchwil ac yn adolygu ceisiadau grant a llawysgrifau ar gyfer nifer o gyllidwyr/cyfnodolion cenedlaethol a rhyngwladol. Mae hefyd yn Arweinydd Academaidd ar gyfer Biobanc Prifysgol Caerdydd sy'n cyflenwi biosamplau dynol ar gyfer ymchwil sy'n canolbwyntio ar wella iechyd pobl.
Aelodaethau proffesiynol
- Cymdeithas Atgyweirio Meinwe Ewropeaidd
Safleoedd academaidd blaenorol
2008 - presennol: Athro Bioleg Celloedd, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2013 - presennol: Trwydded ymchwil HTA Unigol Dynodedig, Prifysgol Caerdydd
2015 - presennol: Arweinydd Academaidd ar gyfer Biobanc Prifysgol Caerdydd, Prifysgol Caerdydd
2024 - presennol: Dirprwy Bennaeth Ysgol: Pobl a Diwylliant, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2025 - 2026: Profost Dros Dro Prifysgol Caerdydd Kazakhstan
2024 - 2026: Deon Rhyngwladol Americas, Prifysgol Caerdydd
2024 - 2025: Pennaeth Ysgol Dros Dro, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2016 - 2022: Deon Rhyngwladol, Coleg y Gwyddorau Biofeddygol a Bywyd, Prifysgol Caerdydd
2017 - 2019: Llywydd Cymdeithas Atgyweirio Meinwe Ewrop
2015 - 2016: Arweinydd Thema Ymchwil ar gyfer Biosystemau Integreiddiol, Coleg y Gwyddorau Biofeddygol a Bywyd, Prifysgol Caerdydd
2010 - 2015: Is-ddeon (Ymchwil), Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2010 - 2015: Pennaeth Sefydliad Peirianneg a Thrwsio Meinweoedd Caerdydd (CITER), Prifysgol Caerdydd
2008 - 2010: Pennaeth Peirianneg Meinweoedd a Deintyddiaeth Atgyweiriol, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2004 - 2008: Darllenydd mewn Bioleg Celloedd, Grŵp Bioleg Clwyfau, Adran Llawfeddygaeth y Geg, Meddygaeth a Patholeg, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2002 - 2004: Uwch Ddarlithydd mewn Bioleg Celloedd, Adran Llawfeddygaeth y Geg, Meddygaeth a Patholeg, Ysgol Ddeintyddol, Y Drindod Dewi Sant, Caerdydd
1998 - 2002: Darlithydd mewn Bioleg Celloedd, Adran Llawfeddygaeth y Geg, Meddygaeth a Patholeg, Ysgol Ddeintyddol, Y Drindod Dewi Sant, Caerdydd
Ebrill - Rhagfyr 1997: Secondiad i Labordai Hematopoiesis Moleciwlaidd yr Athro Corey Largman, UCSF, San Francisco, UDA i ymchwilio i rôl genynnau homeobox newydd mewn iachau clwyfau heb creithiau
1994 - 1998: Cymrawd Ymchwil Ôl-ddoethurol, Adran Llawfeddygaeth y Geg, Meddygaeth a Patholeg, Ysgol Ddeintyddol, Y Drindod Dewi Sant, Caerdydd
Meysydd goruchwyliaeth
- Celloedd progenitor llafar fesiglau allgellog bach fel asiantau gwrth-greithio a gwrthficrobaidd
- Datblygu asiantau olrhain celloedd tymor hir (PET, MRI)
Contact Details
Themâu ymchwil
Arbenigeddau
- Bioleg Celloedd
- Meddygaeth adfywiol
- Celloedd bonyn
- Peirianneg meinwe