![George Tackley MBBCh, Phd](https://profiles-cardiff.imgix.net/attachments/2613?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Trosolwyg
Nid yw ein profiad o'r byd yn drosglwyddiad syml o wybodaeth ysgogol i'r ymennydd. Cymerwch enghraifft o boen. Mae pigo pin-prick ar flaen eich bys yn destun newid ar sawl lefel o fewn y system nerfol, o safle anafiadau lle mae uniondeb ac anaf meinwe yn berthnasol, yr holl ffordd i fyny i'r ymennydd lle mae cyflwr emosiynol a sylwgar yn dod i rym.
Yn rhyfeddol, mae'r ymennydd weithiau'n gweithredu i newid gwybodaeth synhwyraidd ar adeg mynediad yn y llinyn asgwrn cefn. Hynny yw, gall bod yn anhapus neu mewn amgylchedd anarferol newid sut mae gwybodaeth poen yn cael ei phrosesu cyn iddo agosáu at eich ymennydd, weithiau mor bell i lawr â'ch cefn isaf!
Rydym yn aml yn meddwl am y llinyn asgwrn cefn mor bell o'r ymennydd a dim ond cwndid ar gyfer trosglwyddo gwybodaeth o'r tu allan i'r tu mewn. Mae fy ymchwil gyda delweddu MR yn ceisio herio hyn, gan edrych ar y nifer o ffyrdd y caiff gwybodaeth synhwyraidd ei haddasu yn y llinyn a cheisio deall sut mae perthynas agos yr ymennydd a'r llinyn yn llywio sut rydyn ni'n teimlo ac yn gweithredu.
Fel estyniad i'r gwaith hwn, mae gen i ddiddordeb yn y ffordd mae poen yn cael ei brosesu'n wahanol mewn cyflyrau poen cronig, yn enwedig y rhai sydd â phoen 'nociplastic'. Nid oes gan boen nociplastic unrhyw anaf canfyddadwy na niwed i'r nerf ond mae hynny oherwydd newidiadau mewn nerfau a rhwydweithiau. Rwy'n cael fy holi a oes newidiadau nociplastic yn digwydd yn y llinyn a sut y gall hyn haenu cleifion yn well.
Cyhoeddiad
2024
- Khot, S., Tackley, G. and Choy, E. 2024. How to distinguish non-inflammatory from inflammatory pain in RA?. Current Rheumatology Reports 26, pp. 403-413. (10.1007/s11926-024-01159-4)
2021
- Cohen-Adad, J. et al. 2021. Generic acquisition protocol for quantitative MRI of the spinal cord. Nature Protocols 16(10), pp. 4611-4632. (10.1038/s41596-021-00588-0)
- Tackley, G. et al. 2021. An In-vivo 1H-MRS short-echo time technique at 7T: quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue. NeuroImage 238, article number: 118225. (10.1016/j.neuroimage.2021.118225)
- Cohen-Adad, J. et al. 2021. Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers. Scientific Data 8(1), article number: 219. (10.1038/s41597-021-00941-8)
- Wingerchuk, D. et al. 2021. Long-term safety and efficacy of Eculizumab in Aquaporin-4 IgG-positive NMOSD. Annals of Neurology 89(6), pp. 1088-1098. (10.1002/ana.26049)
2017
- Jurynczyk, M. et al. 2017. Clinical presentation and prognosis in MOG-antibody disease: A UK study. Brain 140(12), pp. 3128-3138. (10.1093/brain/awx276)
- Jurynczyk, M. et al. 2017. Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease. Acta Neuropathologica Communications 5(1), article number: 95. (10.1186/s40478-017-0495-8)
- Jurynczyk, M. et al. 2017. Distinct brain imaging characteristics of autoantibody-mediated CNS conditions and multiple sclerosis. Brain 140(3), pp. 617-627. (10.1093/brain/aww350)
- Jurynczyk, M. et al. 2017. Brain lesion distribution criteria distinguish MS from AQP4-antibody NMOSD and MOG-antibody disease. Journal of Neurology, Neurosurgery and Psychiatry 88(2), pp. 132-136. (10.1136/jnnp-2016-314005)
- Tackley, G. et al. 2017. Chronic neuropathic pain severity is determined by lesion level in aquaporin 4-antibody-positive myelitis. Journal of Neurology, Neurosurgery and Psychiatry 88(2), pp. 165-169. (10.1136/jnnp-2016-314991)
2016
- Kong, Y. et al. 2016. Pain in patients with transverse myelitis and its relationship to aquaporin 4 antibody status. Journal of the Neurological Sciences 368, pp. 84-88. (10.1016/j.jns.2016.06.041)
- Tackley, G. et al. 2016. Neuromyelitis optica relapses: Race and rate, immunosuppression and impairment. Multiple Sclerosis and Related Disorders 7, pp. 21-25. (10.1016/j.msard.2016.02.014)
- Piccolo, L. et al. 2016. Isolated new onset ‘atypical’ optic neuritis in the NMO clinic: serum antibodies, prognoses and diagnoses at follow-up. Journal of Neurology 263(2), pp. 370-379. (10.1007/s00415-015-7983-1)
2015
- Waters, P. et al. 2015. MOG cell-based assay detects non-MS patients with inflammatory neurologic disease. Neurology: Neuroimmunology and NeuroInflammation 2(3), article number: e89. (10.1212/NXI.0000000000000089)
2014
- Tackley, G., Kuker, W. and Palace, J. 2014. Magnetic resonance imaging in neuromyelitis optica. Multiple Sclerosis Journal 20(9), pp. 1153-1164. (10.1177/1352458514531087)
Articles
- Khot, S., Tackley, G. and Choy, E. 2024. How to distinguish non-inflammatory from inflammatory pain in RA?. Current Rheumatology Reports 26, pp. 403-413. (10.1007/s11926-024-01159-4)
- Cohen-Adad, J. et al. 2021. Generic acquisition protocol for quantitative MRI of the spinal cord. Nature Protocols 16(10), pp. 4611-4632. (10.1038/s41596-021-00588-0)
- Tackley, G. et al. 2021. An In-vivo 1H-MRS short-echo time technique at 7T: quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue. NeuroImage 238, article number: 118225. (10.1016/j.neuroimage.2021.118225)
- Cohen-Adad, J. et al. 2021. Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers. Scientific Data 8(1), article number: 219. (10.1038/s41597-021-00941-8)
- Wingerchuk, D. et al. 2021. Long-term safety and efficacy of Eculizumab in Aquaporin-4 IgG-positive NMOSD. Annals of Neurology 89(6), pp. 1088-1098. (10.1002/ana.26049)
- Jurynczyk, M. et al. 2017. Clinical presentation and prognosis in MOG-antibody disease: A UK study. Brain 140(12), pp. 3128-3138. (10.1093/brain/awx276)
- Jurynczyk, M. et al. 2017. Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease. Acta Neuropathologica Communications 5(1), article number: 95. (10.1186/s40478-017-0495-8)
- Jurynczyk, M. et al. 2017. Distinct brain imaging characteristics of autoantibody-mediated CNS conditions and multiple sclerosis. Brain 140(3), pp. 617-627. (10.1093/brain/aww350)
- Jurynczyk, M. et al. 2017. Brain lesion distribution criteria distinguish MS from AQP4-antibody NMOSD and MOG-antibody disease. Journal of Neurology, Neurosurgery and Psychiatry 88(2), pp. 132-136. (10.1136/jnnp-2016-314005)
- Tackley, G. et al. 2017. Chronic neuropathic pain severity is determined by lesion level in aquaporin 4-antibody-positive myelitis. Journal of Neurology, Neurosurgery and Psychiatry 88(2), pp. 165-169. (10.1136/jnnp-2016-314991)
- Kong, Y. et al. 2016. Pain in patients with transverse myelitis and its relationship to aquaporin 4 antibody status. Journal of the Neurological Sciences 368, pp. 84-88. (10.1016/j.jns.2016.06.041)
- Tackley, G. et al. 2016. Neuromyelitis optica relapses: Race and rate, immunosuppression and impairment. Multiple Sclerosis and Related Disorders 7, pp. 21-25. (10.1016/j.msard.2016.02.014)
- Piccolo, L. et al. 2016. Isolated new onset ‘atypical’ optic neuritis in the NMO clinic: serum antibodies, prognoses and diagnoses at follow-up. Journal of Neurology 263(2), pp. 370-379. (10.1007/s00415-015-7983-1)
- Waters, P. et al. 2015. MOG cell-based assay detects non-MS patients with inflammatory neurologic disease. Neurology: Neuroimmunology and NeuroInflammation 2(3), article number: e89. (10.1212/NXI.0000000000000089)
- Tackley, G., Kuker, W. and Palace, J. 2014. Magnetic resonance imaging in neuromyelitis optica. Multiple Sclerosis Journal 20(9), pp. 1153-1164. (10.1177/1352458514531087)
Ymchwil
Mae fy niddordebau ymchwil yn cynnwys:
- Prosesu somatosensory (yn enwedig poen, ond hefyd cyffwrdd cosi ac affeithiol)
- delweddu llinyn y cefn (MRI, gan gynnwys MRI swyddogaethol)
- Cyflyrau poen nociplastic (gan gynnwys ffibromyalgia)
- Awtistiaeth (yn enwedig gwahaniaethau synhwyraidd cyffyrddol)
- Datblygu dyfais ar gyfer profion somatosensory
Contact Details
TackleyG@caerdydd.ac.uk
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ