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Dr Luke Tait
(e/fe)
MMath (Liverpool), PhD (Exeter)
Cydymaith Ymchwil Ôl-ddoethurol
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Nod fy ymchwil yw deall sut mae dynameg gweithgaredd electroffisiolegol yr ymennydd yn gysylltiedig ag iechyd ac anhwylderau gwybyddol fel clefyd Alzheimer, epilepsi, a risg o seicosis/sgitsoffrenia. Gyda chefndir mewn ffiseg fathemategol a niwrowyddoniaeth gyfrifiadurol, mae gen i ddiddordeb arbennig mewn datblygu dulliau newydd i holi a modelu gweithgaredd yr ymennydd a fesurir gan MEG, EEG ac MRI.
Ar hyn o bryd rwy'n Gydymaith Ymchwil Ôl-ddoethurol ar brosiect CONVERGE. Nod y prosiect hwn yw deall y cysylltiad rhwng cysylltedd / deinameg yr ymennydd a risgiau genetig sgitsoffrenia. Rwy'n gyfrifol am gasglu data fel delweddu'r ymennydd (MEG, MRI), ac asesiadau gwybyddol, modurol a seiciatrig gan blant gydag amrywiolion rhif copi sy'n gysylltiedig â risg uwch o sgitsoffrenia pan fyddant yn oedolion. Rwyf hefyd yn ymwneud â dadansoddi'r data hwn, ac integreiddio data llinell ddynol / cell/cnofilod ar draws graddfeydd lluosog mewn modelau achosol deinamig.
Cyhoeddiad
2024
- Tait, L. et al. 2024. Estimating the likelihood of epilepsy from clinically noncontributory electroencephalograms using computational analysis: A retrospective, multisite case–control study. Epilepsia 65(8), pp. 2459-2469. (10.1111/epi.18024)
- Maiarù, M. et al. 2024. Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice. The Journal of Pain 25(6), article number: 104466. (10.1016/j.jpain.2024.01.331)
- Kopcanová, M. et al. 2024. Resting-state EEG signatures of Alzheimer's disease are driven by periodic but not aperiodic changes. Neurobiology of Disease 190, article number: 106380. (10.1016/j.nbd.2023.106380)
2022
- Karahan, E. et al. 2022. The interindividual variability of multimodal brain connectivity maintains spatial heterogeneity and relates to tissue microstructure. Communications Biology 5, article number: 1007. (10.1038/s42003-022-03974-w)
- Tait, L. and Zhang, J. 2022. MEG cortical microstates: spatiotemporal characteristics, dynamic functional connectivity and stimulus-evoked responses. NeuroImage 251, article number: 119006. (10.1016/j.neuroimage.2022.119006)
2021
- Tait, L., Ozkan, A., Szul, M. J. and Zhang, J. 2021. A systematic evaluation of source reconstruction of resting MEG of the human brain with a new high-resolution atlas: performance, precision, and parcellation. Human Brain Mapping 42(14), pp. 4685-4707. (10.1002/hbm.25578)
- Tait, L., Lopes, M. A., Stothart, G., Baker, J., Kazanina, N., Zhang, J. and Goodfellow, M. 2021. A large-scale brain network mechanism for increased seizure propensity in Alzheimer's disease. PLoS Computational Biology 17(8), article number: e1009252. (10.1371/journal.pcbi.1009252)
2020
- Lopes, M. A., Junges, L., Tait, L., Terry, J. R., Abela, E., Richardson, M. P. and Goodfellow, M. 2020. Computational modelling in source space from scalp EEG to inform presurgical evaluation of epilepsy. Clinical Neurophysiology 131(1), pp. 225-234. (10.1016/j.clinph.2019.10.027)
- Tait, L. et al. 2020. EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease. Scientific Reports 10, article number: 17627. (10.1038/s41598-020-74790-7)
2019
- Tait, L., Stothart, G., Coulthard, E., Brown, J. T., Kazanina, N. and Goodfellow, M. 2019. Network substrates of cognitive impairment in Alzheimer's Disease. Clinical Neurophysiology 130(9), pp. 1581-1595. (10.1016/j.clinph.2019.05.027)
2018
- Tait, L., Wedgwood, K., Tsaneva-Atanasova, K., Brown, J. T. and Goodfellow, M. 2018. Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells. Journal of Theoretical Biology 449, pp. 23-34. (https://doi.org/10.1016/j.jtbi.2018.04.013)
2016
- Stothart, G., Petkov, G., Kazanina, N., Goodfellow, M., Tait, L. and Brown, J. 2016. Graph-theoretical measures provide translational markers of large-scale brain network disruption in human dementia patients and animal models of dementia. International Journal of Psychophysiology 108, pp. 71-71. (10.1016/j.ijpsycho.2016.07.232)
Erthyglau
- Tait, L. et al. 2024. Estimating the likelihood of epilepsy from clinically noncontributory electroencephalograms using computational analysis: A retrospective, multisite case–control study. Epilepsia 65(8), pp. 2459-2469. (10.1111/epi.18024)
- Maiarù, M. et al. 2024. Substance P-botulinum mediates long-term silencing of pain pathways that can be re-instated with a second injection of the construct in mice. The Journal of Pain 25(6), article number: 104466. (10.1016/j.jpain.2024.01.331)
- Kopcanová, M. et al. 2024. Resting-state EEG signatures of Alzheimer's disease are driven by periodic but not aperiodic changes. Neurobiology of Disease 190, article number: 106380. (10.1016/j.nbd.2023.106380)
- Karahan, E. et al. 2022. The interindividual variability of multimodal brain connectivity maintains spatial heterogeneity and relates to tissue microstructure. Communications Biology 5, article number: 1007. (10.1038/s42003-022-03974-w)
- Tait, L. and Zhang, J. 2022. MEG cortical microstates: spatiotemporal characteristics, dynamic functional connectivity and stimulus-evoked responses. NeuroImage 251, article number: 119006. (10.1016/j.neuroimage.2022.119006)
- Tait, L., Ozkan, A., Szul, M. J. and Zhang, J. 2021. A systematic evaluation of source reconstruction of resting MEG of the human brain with a new high-resolution atlas: performance, precision, and parcellation. Human Brain Mapping 42(14), pp. 4685-4707. (10.1002/hbm.25578)
- Tait, L., Lopes, M. A., Stothart, G., Baker, J., Kazanina, N., Zhang, J. and Goodfellow, M. 2021. A large-scale brain network mechanism for increased seizure propensity in Alzheimer's disease. PLoS Computational Biology 17(8), article number: e1009252. (10.1371/journal.pcbi.1009252)
- Lopes, M. A., Junges, L., Tait, L., Terry, J. R., Abela, E., Richardson, M. P. and Goodfellow, M. 2020. Computational modelling in source space from scalp EEG to inform presurgical evaluation of epilepsy. Clinical Neurophysiology 131(1), pp. 225-234. (10.1016/j.clinph.2019.10.027)
- Tait, L. et al. 2020. EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease. Scientific Reports 10, article number: 17627. (10.1038/s41598-020-74790-7)
- Tait, L., Stothart, G., Coulthard, E., Brown, J. T., Kazanina, N. and Goodfellow, M. 2019. Network substrates of cognitive impairment in Alzheimer's Disease. Clinical Neurophysiology 130(9), pp. 1581-1595. (10.1016/j.clinph.2019.05.027)
- Tait, L., Wedgwood, K., Tsaneva-Atanasova, K., Brown, J. T. and Goodfellow, M. 2018. Control of clustered action potential firing in a mathematical model of entorhinal cortex stellate cells. Journal of Theoretical Biology 449, pp. 23-34. (https://doi.org/10.1016/j.jtbi.2018.04.013)
- Stothart, G., Petkov, G., Kazanina, N., Goodfellow, M., Tait, L. and Brown, J. 2016. Graph-theoretical measures provide translational markers of large-scale brain network disruption in human dementia patients and animal models of dementia. International Journal of Psychophysiology 108, pp. 71-71. (10.1016/j.ijpsycho.2016.07.232)
Bywgraffiad
Ôl-ddoethurol
2022-presennol: Cydymaith Ymchwil, CUBRIC, Prifysgol Caerdydd
Cydgyfeirio: Deall deinameg ymennydd wedi'i newid mewn plant sydd â risg genetig o sgitsoffrenia
2021-2022: Cymrawd Ymchwil, Canolfan Modelu Systemau a Biofeddygaeth Meintiol, Prifysgol Birmingham
Modelu rhagfynegol epilepsi yn seiliedig ar nodweddion ystadegol signalau EEG gorffwys
2019-2021: Cydymaith Ymchwil, CUBRIC, Prifysgol Caerdydd
Prosiect yn gweithio ar rwydweithiau deinamig / microstates mewn gorffwys a thasg wybyddol
Ôl - raddedig
2015-2019: PhD Mathemateg, Sefydliad Systemau Byw, Prifysgol Caerwysg.
Teitl traethawd Ymchwil: Modelu Mathemategol Amlraddfaol Rhwydweithiau Ymennydd mewn Clefyd Alzheimer
Is-raddedig
2011-2015: MMath (Dosbarth 1af Anrh) Ffiseg Fathemategol, Prifysgol Lerpwl
Contact Details
+44 29206 88756
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ