![Philip Taylor](https://profiles-cardiff.imgix.net/attachments/2617?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Philip Taylor
Athro Imiwnoleg Drosiadol
Trosolwyg
I have expertise in study of the innate immune system, in particular, macrophages, myeloid cell surface receptors involved in pathogen recognition and inflammation and the complement system. More recently, I have been engaged in fundamental questions of macrophage biology, relating to origins, development and renewal, and the transcriptional control of cellular activation. I have an additional interest in the development and validation of technologies that promote the 3Rs within a framework of scientific excellence. I have a strong foundation in the study of and development of experimental murine models of disease and immunity. Ultimately, my aim is to elucidate novel mechanisms to manipulate macrophage activity for beneficial outcome in disease.
Cyhoeddiad
2024
- Gurney, M. et al. 2024. Lentiviral vector preparation for efficient gene and microRNA modulation of peritoneal cavity tissue-resident macrophages in vivo in mice. Journal of Visualized Experiments 204, article number: e64926. (10.3791/64926)
- Varache, M. et al. 2024. Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo. RSC Pharmaceutics (10.1039/D3PM00014A)
2023
- Millrine, D. et al. 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211(2), pp. 274-286. (10.4049/jimmunol.2300114)
2022
- Carpanini, S. M. et al. 2022. Terminal complement pathway activation drives synaptic Loss in Alzheimer’s disease models. Acta Neuropathologica Communications 10, article number: 99. (10.1186/s40478-022-01404-w)
- Czubala, M. A. et al. 2022. 3R Blackboard: A platform for animal and organ sharing. Laboratory Animals 56(3), pp. 292-296. (10.1177/00236772211067456)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)
2021
- Griffiths, J. S. et al. 2021. A novel strategy to identify haematology patients at high risk of developing Aspergillosis. Frontiers in Immunology 12, article number: 780160. (10.3389/fimmu.2021.780160)
- Griffiths, J. S. et al. 2021. A human Dectin-2 deficiency associated with invasive aspergillosis. Journal of Infectious Diseases 224(7), pp. 1219-1224. (10.1093/infdis/jiab145)
- Lu, Y. et al. 2021. Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis. Journal of the American Society of Nephrology 32(10), pp. 2501-2516. (10.1681/ASN.2020081143)
- Maguire, E. et al. 2021. PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522. EMBO Journal 40(17), article number: e105603. (10.15252/embj.2020105603)
- Jones, R. E., Andrews, R., Holmans, P., Hill, M. and Taylor, P. R. 2021. Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease. Scientific Reports 11(1), article number: 14935. (10.1038/s41598-021-94324-z)
- Bart, V. M. T., Pickering, R. J., Taylor, P. R. and Ipseiz, N. 2021. Macrophage reprogramming for therapy. Immunology 163(2), pp. 128-144. (10.1111/imm.13300)
- Thompson, A., da Fonseca, D. M., Walker, L., Griffiths, J. S., Taylor, P. R., Gow, N. A. R. and Orr, S. J. 2021. Dependence on Mincle and Dectin-2 varies with multiple Candida species during systemic infection. Frontiers in Microbiology 12, article number: 633229. (10.3389/fmicb.2021.633229)
2020
- Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39(14), article number: e103454. (10.15252/embj.2019103454)
- Ipseiz, N., Czubala, M. A., Bart, V. M., Davies, L. C., Jenkins, R. H., Brennan, P. and Taylor, P. R. 2020. Effective in vivo gene modification in mouse tissue-resident peritoneal macrophages by intraperitoneal delivery of lentiviral vectors. Molecular Therapy - Methods and Clinical Development 16, pp. 21-31. (10.1016/j.omtm.2019.10.004)
2019
- Thompson, A. et al. 2019. Dependence on Dectin-1 varies with multiple candida species. Frontiers in Microbiology 10, article number: 1800. (10.3389/fmicb.2019.01800)
- Zelek, W. M., Taylor, P. R. and Morgan, B. P. 2019. Development and characterisation of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species. Immunology 157(4), pp. 283-295. (10.1111/imm.13083)
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15(6), article number: e1007850. (10.1371/journal.ppat.1007850)
- Twohig, J. P. et al. 2019. Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. Nature Immunology 20, pp. 458-470. (10.1038/s41590-019-0350-0)
2018
- Cabron, A. et al. 2018. Structural and functional analyses of the shedding protease ADAM17 in HoxB8-Immortalized macrophages and dendritic-like cells. Journal of Immunology 201(10), pp. 3106-3118., article number: 1701556. (10.4049/jimmunol.1701556)
- Griffiths, J. S. et al. 2018. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB Journal 32(6), pp. 3385-3397. (10.1096/fj.201701145R)
2017
- Davies, L., Rice, C. M., Palmieri, E. M., Taylor, P., Kuhns, D. B. and McVicar, D. W. 2017. Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels. Nature Communications 8(1), article number: 2074. (10.1038/s41467-017-02092-0)
- Singh, R. et al. 2017. Death receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular Immunology 320, pp. 62-70. (10.1016/j.cellimm.2017.09.005)
- Prince, L. R. et al. 2017. NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood 130(8), pp. 1014-1025., article number: 770164. (10.1182/blood-2017-03-770164)
- Lopez-Anton, M. et al. 2017. miR-21 promotes fibrogenesis in peritoneal dialysis. American Journal of Pathology 187(7), pp. 1537-1550. (10.1016/j.ajpath.2017.03.007)
- Liao, C. et al. 2017. Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes. Kidney International 91(5), pp. 1088-1103. (10.1016/j.kint.2016.10.030)
- Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2(1) (10.12688/wellcomeopenres.10308.1)
2016
- Perks, W. V. et al. 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186(11), pp. 2813-2823. (10.1016/j.ajpath.2016.07.021)
- Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
- Patin, E. et al. 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197(1), pp. 208-221. (10.4049/jimmunol.1501204)
2015
- Liao, C., Fraser, D., Topley, N. and Taylor, P. 2015. Deciphering the peritoneal mononuclear phagocyte system in mice: Steady state and inflammation [Poster abstract]. Nephrology Dialysis Transplantation 30(iii), pp. iii265-. (10.1093/ndt/gfv180.25)
- Liao, C., Fraser, D. J., Topley, N. and Taylor, P. R. 2015. Determining the identity and functional specialization of peritoneal mononuclear phagocytes in peritoneal dialysis patients. Nephrology Dialysis Transplantation 30(S3), pp. iii264., article number: FP569. (10.1093/ndt/gfv180.21)
- Jenkins, R., Liao, C., Wallace, L., Bowen, T., Topley, N., Taylor, P. and Fraser, D. 2015. Microrna regulation of macrophage phenotype in peritoneal fibrosis. Nephrology Dialysis Transplantation 30(iii262) (10.1093/ndt/gfv180.15)
- Davies, L. C. and Taylor, P. R. 2015. Tissue-resident macrophages: then and now. Immunology 144(4), pp. 541-548. (10.1111/imm.12451)
- Stack, G. et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11(2), article number: e1004641. (10.1371/journal.ppat.1004641)
- Liddiard, K. and Taylor, P. R. 2015. Understanding local macrophage phenotypes in disease: shape-shifting macrophages. Nature Medicine 21(2), pp. 119-120. (10.1038/nm.3798)
- Veninga, H. et al. 2015. Antigen targeting reveals splenic CD169+macrophages as promoters of germinal center B-cell responses. European Journal of Immunology 45(3), pp. 747-757. (10.1002/eji.201444983)
2014
- Greenhill, C. J. et al. 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16(4), article number: 419. (10.1186/s13075-014-0419-y)
- Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
- Jenkins, R. H. et al. 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy. American Journal of Pathology 184(4), pp. 996-1009. (10.1016/j.ajpath.2013.12.028)
- Stacey, M. A. et al. 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15(4), pp. 471-483. (10.1016/j.chom.2014.03.003)
- Fielding, C. A. et al. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40(1), pp. 40-50. (10.1016/j.immuni.2013.10.022)
- Ling, G. S. et al. 2014. Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages. Nature Communications 5, article number: 3039. (10.1038/ncomms4039)
2013
- Lauder, S. N. et al. 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43(10), pp. 2613-2625. (10.1002/eji.201243018)
- Greenhill, C. J. et al. 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63(3), pp. 267. (10.1016/j.cyto.2013.06.105)
- Fielding, C. A., Jones, G. W., Taylor, P. R., Jenkins, B. J., Topley, N. and Jones, S. A. 2013. IL-6 regulation of Th1 responses drives fibrosis in unresolved inflammation [Abstract]. Cytokine 63(3), pp. 262. (10.1016/j.cyto.2013.06.082)
- Davies, L. C. et al. 2013. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications 4, article number: 1886. (10.1038/ncomms2877)
- Orr, S. J. et al. 2013. LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells. PLoS Pathogens 9(5), article number: e1003357. (10.1371/journal.ppat.1003357)
- Ma, Y. et al. 2013. Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity 38(4), pp. 729-741. (10.1016/j.immuni.2013.03.003)
- Kuwana, M. et al. 2013. Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. PLoS ONE 8(2), article number: e57082. (10.1371/journal.pone.0057082)
- Davies, L. C., Jenkins, S., Allen, J. and Taylor, P. R. 2013. Tissue-resident macrophages [review]. Nature Immunology 14(10), pp. 986-995. (10.1038/ni.2705)
2012
- Karsten, C. M. et al. 2012. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1 [Letter]. Nature Medicine 18(9), pp. 1401-1406. (10.1038/nm.2862)
- McDonald, J. U., Rosas, M., Brown, G. D., Jones, S. A. and Taylor, P. R. 2012. Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. PLoS ONE 7(9), article number: e45781. (10.1371/journal.pone.0045781)
- Greenhill, C. J. et al. 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137, pp. 43-44.
- Taylor, P. R. et al. 2012. Development of myeloproliferative disease in 12/15-lipoxygenase deficiency [Letter]. Blood 119(25), pp. 6173-6174. (10.1182/blood-2012-02-410928)
- Greenhill, C. et al. 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51, pp. 48-48. (10.1093/rheumatology/kes117)
2011
- Greenhill, C. J. et al. 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135(s1), pp. 158-158. (10.1111/j.1365-2567.2011.03534.x)
- McDonald, J. U. et al. 2011. In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. The FASEB Journal 25(6), pp. 1972-1982. (10.1096/fj.10-178517)
- Lauder, S. N. et al. 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66(5), pp. 368-374. (10.1136/thx.2010.150318)
- Rosas, M. et al. 2011. Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells. European Journal of Immunology 41(2), pp. 356-365. (10.1002/eji.201040962)
- Liddiard, K., Rosas, M., Davies, L. C., Jones, S. A. and Taylor, P. R. 2011. Macrophage heterogeneity and acute inflammation. European Journal of Immunology 41(9), pp. 2503-2508. (10.1002/eji.201141743)
- Davies, L. C., Rosas, M., Smith, P. J., Fraser, D. J., Jones, S. A. and Taylor, P. R. 2011. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology 41(8), pp. 2155-2164. (10.1002/eji.201141817)
- da Glória Sousa, M. et al. 2011. Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin. Cell Host & Microbe 9(5), pp. 436-443. (10.1016/j.chom.2011.04.005)
- Gazi, U. et al. 2011. Fungal Recognition Enhances Mannose Receptor Shedding through Dectin-1 Engagement. Journal of Biological Chemistry 286(10), pp. 7822-7829. (10.1074/jbc.M110.185025)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
- Boyle, K. B. et al. 2011. Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to aspergillus fumigatus hyphae. The Journal of Immunology 186(5), pp. 2978-2989. (10.4049/jimmunol.1002268)
2010
- Suram, S. et al. 2010. Pathways Regulating Cytosolic Phospholipase A2 Activation and Eicosanoid Production in Macrophages by Candida albicans. Journal of Biological Chemistry 285(40), pp. 30676-30685. (10.1074/jbc.M110.143800)
- Wang, J. et al. 2010. Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood 116(26), pp. 5991-6002. (10.1182/blood-2010-04-281527)
- Rosas, M., Thomas, B., Stacey, M., Gordon, S. and Taylor, P. R. 2010. The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B. Journal of leukocyte biology 88(1), pp. 169-180. (10.1189/jlb.0809548)
2009
- Jones, H. E., Taylor, P. R., McGreal, E. P., Zamze, S. and Wong, S. Y. C. 2009. The contribution of naturally occurring IgM antibodies, IgM cross-reactivity and complement dependency in murine humoral responses to pneumococcal capsular polysaccharides. Vaccine 27(42), pp. 5806-5815. (10.1016/j.vaccine.2009.07.063)
- Robinson, M. J. et al. 2009. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. Journal of Experimental Medicine 206(9), pp. 2037-2051. (10.1084/jem.20082818)
- Morgan, A. H. et al. 2009. Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. Journal of Biological Chemistry 284(32), pp. 21185-21191. (10.1074/jbc.M109.021634)
- Tsoni, S. V. et al. 2009. Complement C3 plays an essential role in the control of opportunistic fungal infections. Infection and Immunity 77(9), pp. 3679-3685. (10.1128/IAI.00233-09)
- Parti, R. P. et al. 2009. Cytosolic phospholipase A2 activation by candida albicans in alveolar macrophages: role of dectin-1. American Journal of Respiratory Cell and Molecular Biology 42(4), pp. 415-423. (10.1165/rcmb.2009-0110OC)
- Kerrigan, A. M. et al. 2009. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. The Journal of Immunology 182(7), pp. 4150-4157. (10.4049/jimmunol.0802808)
2008
- Heinsbroek, S. E. M., Taylor, P. R., Martinez, F. O., Martinez-Pomares, L., Brown, G. D. and Gordon, S. 2008. Stage-specific sampling by pattern recognition receptors during candida albicans phagocytosis. PLoS Pathogens 4(11), article number: e1000218. (10.1371/journal.ppat.1000218)
- Rosas, M. et al. 2008. The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis. Journal of Immunology 181(5), pp. 3549-3557.
- Hams, E. et al. 2008. Oncostatin M receptor-β signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181(3), pp. 2174-2180.
- Hams, E. et al. 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181(3), pp. 2174-2180.
- Dennehy, K. M. et al. 2008. Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. European Journal of Immunology 38(2), pp. 500-506. (10.1002/eji.200737741)
- Dioszeghy, V. et al. 2008. 12/15-lipoxygenase regulates the inflammatory response to bacterial products in vivo. The Journal of Immunology 181(9), pp. 6514-6524.
- Pyz, E., Huysamen, C., Marshall, A. S. J., Gordon, S., Taylor, P. R. and Brown, G. D. 2008. Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand. European Journal of Immunology 38(4), pp. 1157-1163. (10.1002/eji.200738057)
- Saunders, S. P. et al. 2008. The C-type lectin SIGNR1 binds schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection. Infection and Immunity 77(1), pp. 399-404. (10.1128/IAI.00762-08)
2007
- Hams, E. et al. 2007. Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract]. Cytokine 39(1), pp. 14-14. (10.1016/j.cyto.2007.07.053)
- Taylor, P. R. et al. 2007. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nature Immunology 8(1), pp. 31-38. (10.1038/ni1408)
2006
- McGreal, E. P. et al. 2006. The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 16(5), pp. 422-30. (10.1093/glycob/cwj077)
2004
- Taylor, P. R., Brown, G. D., Herre, J., Williams, D. L., Willment, J. A. and Gordon, S. 2004. The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophages. The Journal of Immunology 172(2), pp. 1157-1162.
2003
- Williams, D. L., Rice, R., Herre, J., Willment, J. A., Taylor, P. R., Gordon, P. R. and Brown, G. D. 2003. Recognition of fungal glucans by pattern recognition receptors. In: Pandalai, S. G. ed. Recent Developments in Carbohydrate Research., Vol. 1. Trivandum: Transworld Research Network, pp. 49-66.
2002
- Taylor, P. R., Brown, G. D., Reid, D. M., Willment, J. A., Gordon, S., Martinez-Pomares, L. and Wong, S. Y. C. 2002. The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. Journal of Immunology 169(7), pp. 3876-3882.
- Brown, G. D. et al. 2002. Dectin-1 is a major beta-glucan receptor on macrophages. Journal of Experimental Medicine 196(3), pp. 407-12. (10.1084/jem.20020470)
Adrannau llyfrau
- Williams, D. L., Rice, R., Herre, J., Willment, J. A., Taylor, P. R., Gordon, P. R. and Brown, G. D. 2003. Recognition of fungal glucans by pattern recognition receptors. In: Pandalai, S. G. ed. Recent Developments in Carbohydrate Research., Vol. 1. Trivandum: Transworld Research Network, pp. 49-66.
Erthyglau
- Gurney, M. et al. 2024. Lentiviral vector preparation for efficient gene and microRNA modulation of peritoneal cavity tissue-resident macrophages in vivo in mice. Journal of Visualized Experiments 204, article number: e64926. (10.3791/64926)
- Varache, M. et al. 2024. Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo. RSC Pharmaceutics (10.1039/D3PM00014A)
- Millrine, D. et al. 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211(2), pp. 274-286. (10.4049/jimmunol.2300114)
- Carpanini, S. M. et al. 2022. Terminal complement pathway activation drives synaptic Loss in Alzheimer’s disease models. Acta Neuropathologica Communications 10, article number: 99. (10.1186/s40478-022-01404-w)
- Czubala, M. A. et al. 2022. 3R Blackboard: A platform for animal and organ sharing. Laboratory Animals 56(3), pp. 292-296. (10.1177/00236772211067456)
- Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)
- Griffiths, J. S. et al. 2021. A novel strategy to identify haematology patients at high risk of developing Aspergillosis. Frontiers in Immunology 12, article number: 780160. (10.3389/fimmu.2021.780160)
- Griffiths, J. S. et al. 2021. A human Dectin-2 deficiency associated with invasive aspergillosis. Journal of Infectious Diseases 224(7), pp. 1219-1224. (10.1093/infdis/jiab145)
- Lu, Y. et al. 2021. Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis. Journal of the American Society of Nephrology 32(10), pp. 2501-2516. (10.1681/ASN.2020081143)
- Maguire, E. et al. 2021. PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease-protective variant PLCγ2 R522. EMBO Journal 40(17), article number: e105603. (10.15252/embj.2020105603)
- Jones, R. E., Andrews, R., Holmans, P., Hill, M. and Taylor, P. R. 2021. Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease. Scientific Reports 11(1), article number: 14935. (10.1038/s41598-021-94324-z)
- Bart, V. M. T., Pickering, R. J., Taylor, P. R. and Ipseiz, N. 2021. Macrophage reprogramming for therapy. Immunology 163(2), pp. 128-144. (10.1111/imm.13300)
- Thompson, A., da Fonseca, D. M., Walker, L., Griffiths, J. S., Taylor, P. R., Gow, N. A. R. and Orr, S. J. 2021. Dependence on Mincle and Dectin-2 varies with multiple Candida species during systemic infection. Frontiers in Microbiology 12, article number: 633229. (10.3389/fmicb.2021.633229)
- Ipseiz, N. et al. 2020. Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway. EMBO Journal 39(14), article number: e103454. (10.15252/embj.2019103454)
- Ipseiz, N., Czubala, M. A., Bart, V. M., Davies, L. C., Jenkins, R. H., Brennan, P. and Taylor, P. R. 2020. Effective in vivo gene modification in mouse tissue-resident peritoneal macrophages by intraperitoneal delivery of lentiviral vectors. Molecular Therapy - Methods and Clinical Development 16, pp. 21-31. (10.1016/j.omtm.2019.10.004)
- Thompson, A. et al. 2019. Dependence on Dectin-1 varies with multiple candida species. Frontiers in Microbiology 10, article number: 1800. (10.3389/fmicb.2019.01800)
- Zelek, W. M., Taylor, P. R. and Morgan, B. P. 2019. Development and characterisation of novel anti-C5 monoclonal antibodies capable of inhibiting complement in multiple species. Immunology 157(4), pp. 283-295. (10.1111/imm.13083)
- Thompson, A. et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15(6), article number: e1007850. (10.1371/journal.ppat.1007850)
- Twohig, J. P. et al. 2019. Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. Nature Immunology 20, pp. 458-470. (10.1038/s41590-019-0350-0)
- Cabron, A. et al. 2018. Structural and functional analyses of the shedding protease ADAM17 in HoxB8-Immortalized macrophages and dendritic-like cells. Journal of Immunology 201(10), pp. 3106-3118., article number: 1701556. (10.4049/jimmunol.1701556)
- Griffiths, J. S. et al. 2018. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB Journal 32(6), pp. 3385-3397. (10.1096/fj.201701145R)
- Davies, L., Rice, C. M., Palmieri, E. M., Taylor, P., Kuhns, D. B. and McVicar, D. W. 2017. Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels. Nature Communications 8(1), article number: 2074. (10.1038/s41467-017-02092-0)
- Singh, R. et al. 2017. Death receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Cellular Immunology 320, pp. 62-70. (10.1016/j.cellimm.2017.09.005)
- Prince, L. R. et al. 2017. NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival. Blood 130(8), pp. 1014-1025., article number: 770164. (10.1182/blood-2017-03-770164)
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- Fielding, C. A., Jones, G. W., Taylor, P. R., Jenkins, B. J., Topley, N. and Jones, S. A. 2013. IL-6 regulation of Th1 responses drives fibrosis in unresolved inflammation [Abstract]. Cytokine 63(3), pp. 262. (10.1016/j.cyto.2013.06.082)
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- Davies, L. C., Jenkins, S., Allen, J. and Taylor, P. R. 2013. Tissue-resident macrophages [review]. Nature Immunology 14(10), pp. 986-995. (10.1038/ni.2705)
- Karsten, C. M. et al. 2012. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1 [Letter]. Nature Medicine 18(9), pp. 1401-1406. (10.1038/nm.2862)
- McDonald, J. U., Rosas, M., Brown, G. D., Jones, S. A. and Taylor, P. R. 2012. Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. PLoS ONE 7(9), article number: e45781. (10.1371/journal.pone.0045781)
- Greenhill, C. J. et al. 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137, pp. 43-44.
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- Liddiard, K., Rosas, M., Davies, L. C., Jones, S. A. and Taylor, P. R. 2011. Macrophage heterogeneity and acute inflammation. European Journal of Immunology 41(9), pp. 2503-2508. (10.1002/eji.201141743)
- Davies, L. C., Rosas, M., Smith, P. J., Fraser, D. J., Jones, S. A. and Taylor, P. R. 2011. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology 41(8), pp. 2155-2164. (10.1002/eji.201141817)
- da Glória Sousa, M. et al. 2011. Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin. Cell Host & Microbe 9(5), pp. 436-443. (10.1016/j.chom.2011.04.005)
- Gazi, U. et al. 2011. Fungal Recognition Enhances Mannose Receptor Shedding through Dectin-1 Engagement. Journal of Biological Chemistry 286(10), pp. 7822-7829. (10.1074/jbc.M110.185025)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
- Boyle, K. B. et al. 2011. Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to aspergillus fumigatus hyphae. The Journal of Immunology 186(5), pp. 2978-2989. (10.4049/jimmunol.1002268)
- Suram, S. et al. 2010. Pathways Regulating Cytosolic Phospholipase A2 Activation and Eicosanoid Production in Macrophages by Candida albicans. Journal of Biological Chemistry 285(40), pp. 30676-30685. (10.1074/jbc.M110.143800)
- Wang, J. et al. 2010. Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood 116(26), pp. 5991-6002. (10.1182/blood-2010-04-281527)
- Rosas, M., Thomas, B., Stacey, M., Gordon, S. and Taylor, P. R. 2010. The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B. Journal of leukocyte biology 88(1), pp. 169-180. (10.1189/jlb.0809548)
- Jones, H. E., Taylor, P. R., McGreal, E. P., Zamze, S. and Wong, S. Y. C. 2009. The contribution of naturally occurring IgM antibodies, IgM cross-reactivity and complement dependency in murine humoral responses to pneumococcal capsular polysaccharides. Vaccine 27(42), pp. 5806-5815. (10.1016/j.vaccine.2009.07.063)
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- Heinsbroek, S. E. M., Taylor, P. R., Martinez, F. O., Martinez-Pomares, L., Brown, G. D. and Gordon, S. 2008. Stage-specific sampling by pattern recognition receptors during candida albicans phagocytosis. PLoS Pathogens 4(11), article number: e1000218. (10.1371/journal.ppat.1000218)
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Ymchwil
Current Research:
Research is carried out under the umbrella of the ‘Myeloid Cell Biology’ Group (led by Prof. Taylor and Dr. Selinda Orr (Wellcome Trust funded Sir Henry Dale Fellow).
The Myeloid Cell Biology group is interested primarily in macrophages, but also dendritic cells and neutrophils. These cells are phagcocytes, specialised blood cells, which ingest other cells (both microbial and self) as well as foreign particles. Phagocytes have diverse roles during development, host defence, inflammation (mediation and resolution), wound healing, immune surveillance and alteration of the adaptive immune response.
Professional phagocytes are defined by their expression of a diverse array of receptors for recognising invading organisms such as bacteria and fungi, dead and dying cells, abnormal host cells and environmental particles. These receptors are ‘opsonic’, such as the Fc and complement receptors, and ‘non-opsonic’, such as the Toll-like receptors, and specific cell surface lectins.
The Myeloid Cell Biology group is primarily interested in fundamental aspects of phagocyte biology, such as the receptors used to recognise pathogens, the signalling molecules involved in the subsequent downstream cellular activation events and fundamental aspects of cell biology such as the regulation of apoptosis or cell renewal. Understanding, how phagocytes respond to specific challenges presents an opportunity to manipulate the behaviour of cells at the very heart of innate and adaptive immunity.
Ongoing Projects are primarily in the areas of:
- Macrophage biology in homeostasis and disease
- Collaborative and Redundant Roles of C-type Lectin-like Receptors in Anti-Fungal Immunity
Current Grant Funding:
- Wellcome Trust Investigator Award (2016-2021). “Understanding the molecular controls of tissue resident macrophages” (Sole Applicant). £1.41M.
- MRC International Mouse Phenotyping Consortium (IMPC) Pump Prime Award (2016-2018). “IMPC: Characterisation of a novel Alzheimer’s disease susceptibility locus” (Lead applicant with L. Jones, M. Hill & B.P. Morgan). £24,024 (fEC: Exception).
- Kidney Research UK Postdoctoral Fellowship: awarded to Chia-Te Liao (2016-2019; Lead sponsor). £246,000.
- MRC Project Grant (2016-2019). “Innate pathogen sensing by unconventional T cells during microbial infections” (Co-applicant with M. Eberl (lead), D.Price, D. Fraser, J. Rossjohn & K. Ladell). £660,663 (100% of fEC).
- Ser Cymru Equipment Award for an Amnis ImageStreamx MkII 2015-2020; £225,923. Supplemented with £100,000 from the Systems Immunity University Research Institute and £68,348 from Cardiff University’s Research Infrastructure Fund (Total Value of bid: £394,271)
- MRC-DTP Studentship (Ruth Jones) (2015-2019). £75,000 approx (3.5 year duration).
- Wellcome Trust Sir Henry Wellcome Postdoctoral Fellowship: awarded to Luke Davies 2015-2019 (Sponsor). £250,000.
- Kidney research UK (Fellowship to Dr. Rob Jenkins). “Control of peritoneal macrophage phenotype by microRNAs” (co-applicant with D. Fraser (lead sponsor), T. Bowen and N. Topley). £192,656.
- Cardiff University PhD studentship (Robert Pickering) (2013-2017). ~£68,000.
- Cardiff University PhD studentship (Leah Wallace) (2013-2017). ~£75,000.
- Cardiff University LREF (Large Research Equipment Fund) (2011-2016) “Polychromatic cell-sorting at Cardiff University’s Medical School” (lead applicant with A. Gallimore, C. Pepper and G. Wilkinson). £150,000.
- Wellcome Trust Programme Grant (2011-2016) “Chemical and biological actions of esterified eicosanoids generated by human immune cells: Understanding membrane signaling actions of novel lipid families” (coapplicant with V O’Donnell (lead), S. Jones, P. Collins and I. Sabroe (Sheffield)). £1,202,625.
Further Reading:
Rosas, M., Davies, L.C., Giles, P.J., Liao, C-T., Kharfan, B., Stone, T.C., O’Donnell, V.B., Fraser, D.J., Jones, S.A. & Taylor, P.R. 2014. “The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal”. Science 344: 645-648.
Davies, L.C., Rosas, M., Jenkins, S., Liao, C., Scurr, M.J., Brombacher, F., Fraser, D.J., Allen, J.E., Jones, S.A. & Taylor, P.R. 2013. “Distinct bone marrow-derived and tissue resident macrophage-lineages proliferate at key stages during inflammation”. Nat. Commun., 4: 1886.
Davies, L.C., Jenkins, S.J., Allen, J.E. & Taylor, P.R. 2013. “Tissue Resident Macrophages”. Nat Immunol., 14: 986-995.
Bywgraffiad
Education and qualifications
| 1998 | PhD | Molecular Genetics, Imperial College London. |
| 1994 | BSc | Human Genetics, University College London. |
Career overview
| 2016- | Wellcome Trust Investigator | Cardiff Institute of Infection and Immunity, Cardiff University. |
| 2012- | Professor of Translational Immunology | Cardiff Institute of Infection and Immunity, Cardiff University. |
| 2007-2012 | Medical Research Council Senior Research Fellowship/Reader | Department of Infection, Immunity and Biochemistry, Cardiff University. |
| 2006-2007 | Wellcome Trust Research Career Development Fellowship | Department of Medical Biochemistry and Immunology, Cardiff University. |
| 2003-2006 | Wellcome Trust Research Career Development Fellowship | Sir William Dunn School of Pathology, Oxford University. |
| 1999-2002 | Wellcome Trust Postdoctoral Research Associate | Sir William Dunn School of Pathology, Oxford University. |
| 1998-1999 | Wellcome Trust Postdoctoral Research Associate | Hammersmith Hospital, Imperial College School of Medicine, London. |
| 1997-1998 | Arthritis Research Campaign Postdoctoral Research Associate | Hammersmith Hospital, Imperial College School of Medicine, London. |
Anrhydeddau a dyfarniadau
| 2016-2021 | Enillydd Gwobr Ymchwilydd Ymddiriedolaeth Wellcome |
| 2007-2014 | Derbynnydd Uwch Gymrodoriaeth y Cyngor Ymchwil Meddygol |
| 2006 | Dyfarnwyd statws Athro Ymchwil , Prifysgol Rhydychen |
| 2003-2007 | Derbynnydd Cymrodoriaeth Datblygu Gyrfa Ymchwil Ymddiriedolaeth Wellcome |
| 2002 | Dyfarnwyd statws RSII, Prifysgol Rhydychen. |
| 1994 | Derbynnydd efrydiaeth PhD y Cyngor Ymchwil Feddygol. |
Pwyllgorau ac adolygu
- 2015 - presennol: Bwrdd Rheoli Partneriaeth Hyfforddiant MRC-Doethurol GW4 y Brifysgol
- 2015 - presennol: Grŵp Strategaeth MRC y Brifysgol
- 2015 - presennol: Pwyllgor Gweithredol Sefydliad Ymchwil Prifysgol Imiwnedd Systemau (SIURI)
- 2015 - presennol: Sefydliad Ymchwil Ôl-raddedig Sefydliad Ymchwil Prifysgol Imiwnedd Systemau
- 2013 - presennol: Pwyllgor Biowybodeg a Bioystadegau'r Ysgol Meddygaeth
- 2011 - presennol: Pwyllgor Graddau Ymchwil yr Ysgol Meddygaeth
- 2011 - presennol: Is-adran/Pwyllgor Gweithredol Sefydliad Heintiau ac Imiwnedd
- 2011 - presennol: Division/Insitute of Infection and Immunity Research Group
- 2011 - presennol: Cynrychiolydd PGR ar gyfer yr Is-adran/Sefydliad Heintiau ac Imiwnedd
- 2009 - 2011: Pwyllgor Llywio Grŵp Ymchwil Rhyngddisgyblaethol Heintiau ac Imiwnedd a Llid