Yr Athro Anita Thapar

Athro, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol

: Thapar@caerdydd.ac.uk
: +44 29206 88325
: Adeilad Hadyn Ellis, Ystafell 3.07, Heol Maendy, Caerdydd, CF24 4HQ

: Sylwebydd y cyfryngau
: Ar gael fel goruchwyliwr ôl-raddedig

I direct the developmental disorders group within the MRC Centre for Neuropsychiatric Genetics and Genomics and Division of Psychological Medicine and Clinical Neurosciences.

I am also a senior investigator in the National Centre for Mental Health (http://www.cardiff.ac.uk/mrc-centre-neuropsychiatric-genetics-genomics/research/themes/national-centre-for-mental-health),Wales' first Biomedical Research Centre.

My research focuses on child neurodevelopmental disorders, genetics and early environmental exposures.

Date
Type

2017

Hubble, K., Daughters, K., Manstead, A., Rees, D., Thapar, A. and Van Goozen, S. 2017. Oxytocin increases attention to the eyes and selectively enhances self-reported affective empathy for fear. Neuropsychologia 106, pp. 350-357. (10.1016/j.neuropsychologia.2017.10.019)
Bevan-Jones, R., Thapar, A., Stone, Z., Thapar, A., Jones, I. R., Smith, D. and Simpson, S. 2017. Psychoeducational interventions in adolescent depression: A systematic review. Patient Education and Counseling (10.1016/j.pec.2017.10.015)
Bhugra, D. et al. 2017. The WPA-Lancet Psychiatry Commission on the future of psychiatry. The Lancet Psychiatry 4(10), pp. 775-818. (10.1016/S2215-0366(17)30333-4)
Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
Eyre, O., Langley, K., Stringaris, A., Leibenluft, E., Collishaw, S. and Thapar, A. 2017. Irritability in ADHD: Associations with depression liability. Journal of Affective Disorders 215, pp. 281-287. (10.1016/j.jad.2017.03.050)
Stergiakouli, E. et al. 2017. Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population. International Journal of Epidemiology 46(2), pp. 421-428. (10.1093/ije/dyw216)
Stergiakouli, E. et al. 2017. Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development. Molecular Autism 8, article number: 18. (10.1186/s13229-017-0131-2)
Thapar, A., Cooper, M. and Rutter, M. 2017. Neurodevelopmental disorders. The Lancet Psychiatry 4(4), pp. 339-346. (10.1016/S2215-0366(16)30376-5)
Stergiakouli, E., Thapar, A. and Davey Smith, G. 2017. Acetaminophen in pregnancy and adverse childhood neurodevelopment-reply. JAMA Pediatrics 171(4) (10.1001/jamapediatrics.2016.5040)
Riglin, L., Collishaw, S., Richards, A., Thapar, A., Maughan, B., O'Donovan, M. C. and Thapar, A. 2017. Schizophrenia polygenic risk score and psychotic risk detection - authors' reply. The Lancet Psychiatry 4(3), pp. 188-189. (10.1016/S2215-0366(17)30052-4)
Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2017. Maternal psychopathology and offspring clinical outcome: a four-year follow-up of boys with ADHD. European Child and Adolescent Psychiatry 26(2), pp. 253-262. (10.1007/s00787-016-0873-y)
Thapar, A. 2017. Intellectual disability and attention-deficit/hyperactivity disorder: What does the clinical and genetic overlap mean for practice and research?. Journal of the American Academy of Child & Adolescent Psychiatry 56(2), pp. 105-106. (10.1016/j.jaac.2016.11.012)
Stuart-Smith, J., Thapar, A., Maughan, B., Thapar, A. and Collishaw, S. 2017. Childhood hyperactivity and mood problems at mid-life: evidence from a prospective birth cohort. Social Psychiatry and Psychiatric Epidemiology 52(1), pp. 87-94. (10.1007/s00127-016-1285-5)
Munoz Solomando, A. and Thapar, A. 2017. Attention Deficit Hyperactivity Disorder. In: Skuse, D., Bruce, H. and Dowdney, L. eds. Child Psychology and Psychiatry: Frameworks for Clinical Training and Practice. Wiley, pp. 203-214.

2016

Caye, A. et al. 2016. Life span studies of ADHD - conceptual challenges and predictors of persistence and outcome. Current Psychiatry Reports 18(12), article number: 111. (10.1007/s11920-016-0750-x)
Hubble, K., Daughters, K., Manstead, A., Rees, D. A., Thapar, A. and Van Goozen, S. 2016. Oxytocin reduces face processing time but leaves recognition accuracy and eye-gaze unaffected. Journal of the International Neuropsychological Society 23(1), pp. 23-33. (10.1017/S1355617716000886)
Stergiakouli, E., Thapar, A. and Davey Smith, G. 2016. Association of acetaminophen use during pregnancy with behavioral problems in childhood. JAMA Pediatrics 170(10), pp. 964-970. (10.1001/jamapediatrics.2016.1775)
Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
Thapar, A. et al. 2016. Identifying key parent-reported symptoms for detecting depression in high risk adolescents. Psychiatry Research 242, pp. 210-217. (10.1016/j.psychres.2016.05.025)
Davidovich, S., Collishaw, S., Thapar, A. K., Harold, G., Thapar, A. and Rice, F. 2016. Do better executive functions buffer the effect of current parental depression on adolescent depressive symptoms?. Journal of Affective Disorders 199, pp. 54-64. (10.1016/j.jad.2016.03.049)
Martin, J. et al. 2016. Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study. American Journal of Epidemiology 183(12), pp. 1149-1158. (10.1093/aje/kww009)
Northover, C., Thapar, A., Langley, K., Fairchild, G. and Van Goozen, S. H. M. 2016. Cortisol levels at baseline and under stress in adolescent males with Attention-Deficit Hyperactivity Disorder, with or without comorbid Conduct Disorder. Psychiatry Research 242, pp. 130-136. (10.1016/j.psychres.2016.05.052)
Riglin, L., Thapar, A., Shelton, K. H., Langley, K., Frederickson, N. and Rice, F. 2016. Profiling depression in childhood and adolescence: the role of conduct problems. Journal of Child Psychology and Psychiatry 57(4), pp. 481-490. (10.1111/jcpp.12465)
van Goozen, S. H. M. et al. 2016. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. Journal of Child Psychology and Psychiatry 57(4), pp. 472-480. (10.1111/jcpp.12464)
Thapar, A. and Cooper, M. 2016. Attention deficit hyperactivity disorder. Lancet 387(10024), pp. 1240-1250. (10.1016/S0140-6736(15)00238-X)
Sellers, R. et al. 2016. Examining whether offspring psychopathology influences illness course in mothers with recurrent depression using a high-risk longitudinal sample. Journal of Abnormal Psychology 125(2), pp. 256-266. (10.1037/abn0000080)
Hammerton, G., Zammit, S., Thapar, A. and Collishaw, S. 2016. Explaining risk for suicidal ideation in adolescent offspring of mothers with depression. Psychological Medicine -London- 46(2), pp. 265-275. (10.1017/S0033291715001671)

2015

Daughters, K., Manstead, A. S. R., Hubble, K., Rees, D. A., Thapar, A. and Van Goozen, S. H. M. 2015. Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study. PLoS ONE 10(12), article number: e0145104. (10.1371/journal.pone.0145104)
Niarchou, M., Martin, J., Thapar, A., Owen, M. J. and van den Bree, M. B. 2015. The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168(8), pp. 730-738. (10.1002/ajmg.b.32378)
Hammerton, G., Zammit, S., Sellers, R., Thapar, A., Collishaw, S., Mahedy, L. and Pearson, R. 2015. In Reply. Journal of the American Academy of Child & Adolescent Psychiatry 54(10), pp. 868-869. (10.1016/j.jaac.2015.07.012)
Northover, C., Thapar, A., Langley, K. and van Goozen, S. H. M. 2015. Emotion regulation in adolescent males with attention-deficit hyperactivity disorder: testing the effects of comorbid conduct disorder. Brain Sciences 5(3), pp. 369-386. (10.3390/brainsci5030369)
Mars, B. et al. 2015. Longitudinal symptom course in adults with recurrent depression: Impact on impairment and risk of psychopathology in offspring. Journal of Affective Disorders 182, pp. 32-38. (10.1016/j.jad.2015.04.018)
Northover, C., Thapar, A., Langley, K. and Van Goozen, S. H. M. 2015. Pain sensitivity in adolescent males with Attention-Deficit/Hyperactivity Disorder: Testing for associations with conduct disorder and callous and unemotional traits. PloS ONE 10(7), article number: e0134417. (10.1371/journal.pone.0134417)
Thapar, A. and Rutter, M. 2015. Neurodevelopmental disorders. In: Thapar, A. et al. eds. Rutter's Child and Adolescent Psychiatry. Wiley-Blackwell, pp. 31-40., (10.1002/9781118381953.ch3)
Thapar, A. and Rutter, M. 2015. Using natural experiments and animal models to study causal hypotheses in relation to child mental health problems. In: Thapar, A. et al. eds. Rutter's Child and Adolescent Psychiatry. Wiley-Blackwell, pp. 143-162., (10.1002/9781118381953)
State, M. and Thapar, A. 2015. Genetics. In: Thapar, A. et al. eds. Rutter's Child and Adolescent Psychiatry. Wiley-Blackwell, pp. 303-316., (10.1002/9781118381953.ch24)
Thapar, A. et al. eds. 2015. Rutter's child and adolescent psychiatry. 6th ed.. Wiley-Blackwell. (10.1002/9781118381953)
Hammerton, G., Mahedy, L., Mars, B., Harold, G. T., Thapar, A., Zammit, S. and Collishaw, S. 2015. Association between maternal depression symptoms across the first eleven years of their child's life and subsequent offspring suicidal ideation. Plos One 10(7), article number: e0131885. (10.1371/journal.pone.0131885)
Thapar, A. 2015. Parents and genes and their effects on alcohol, drugs, and crime in triparental families. American Journal of Psychiatry 172(6), pp. 508-509. (10.1176/appi.ajp.2015.15020263)
Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 56(6), pp. 648-656. (10.1111/jcpp.12336)
Hammerton, G., Zammit, S., Mahedy, L., Pearson, R. M., Sellers, R., Thapar, A. and Collishaw, S. 2015. Pathways to suicide-related behavior in offspring of mothers with depression: the role of offspring psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry 54(5), pp. 385-393. (10.1016/j.jaac.2015.02.006)
Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
Kilford, E. J., Foulkes, L., Potter, R., Collishaw, S., Thapar, A. and Rice, F. 2015. Affective bias and current, past and future adolescent depression: a familial high risk study. Journal of Affective Disorders 174, pp. 265-271. (10.1016/j.jad.2014.11.046)
O'Dushlaine, C. et al. 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 18(2), pp. 199-209. (10.1038/nn.3922)
Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
Cooper, M., Thapar, A. and Jones, D. K. 2015. ADHD severity is associated with white matter microstructure in the subgenual cingulum. NeuroImage: Clinical 7, pp. 653-660. (10.1016/j.nicl.2015.02.012)
Sellers, R., Maughan, B., Pickles, A., Thapar, A. and Collishaw, S. 2015. Trends in parent- and teacher-rated emotional, conduct and ADHD problems and their impact in prepubertal children in Great Britain: 1999-2008. Journal of Child Psychology and Psychiatry 56(1), pp. 49-57. (10.1111/jcpp.12273)

2014

Cooper, M., Thapar, A. and Jones, D. 2014. Erratum to: White matter microstructure predicts autistic traits in Attention-Deficit/Hyperactivity Disorder. Journal of Autism and Developmental Disorders 44(11), pp. 2755. (10.1007/s10803-014-2162-2)
Rawal, A., Riglin, L., Ng-Knight, T., Collishaw, S., Thapar, A. and Rice, F. 2014. A longitudinal high-risk study of adolescent anxiety, depression and parent-severity on the developmental course of risk-adjustment. Journal of Child Psychology and Psychiatry 55(11), pp. 1270-1278. (10.1111/jcpp.12279)
Cooper, M., Thapar, A. and Jones, D. K. 2014. White matter microstructure predicts autistic traits in attention-deficit/hyperactivity disorder. Journal of Autism and Developmental Disorders 44(11), pp. 2742-2754. (10.1007/s10803-014-2131-9)
Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2014. Genetic risk for Attention Deficit/Hyperactivity Disorder contributes to neurodevelopmental traits in the general population. Biological Psychiatry 76(8), pp. 664-671. (10.1016/j.biopsych.2014.02.013)
Thapar, A. and Harold, G. T. 2014. Editorial Perspective: Why is there such a mismatch between traditional heritability estimates and molecular genetic findings for behavioural traits?. Journal of Child Psychology and Psychiatry 55(10), pp. 1088-1091. (10.1111/jcpp.12294)
Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53(7), pp. 761-770.e26. (10.1016/j.jaac.2014.03.004)
Eyre, O. et al. 2014. Reported child awareness of parental depression. Psychiatric Bulletin 38(3), pp. 122-127. (10.1192/pb.bp.113.044198)
Hay, D. F. et al. 2014. Precursors to aggression are evident by 6 months of age. Developmental Science 17(3), pp. 471-480. (10.1111/desc.12133)
Lewis, G., Collishaw, S., Thapar, A. and Harold, G. T. 2014. Parent-child hostility and child and adolescent depression symptoms: the direction of effects, role of genetic factors and gender. European Child & Adolescent Psychiatry 23(5), pp. 317-327. (10.1007/s00787-013-0460-4)
Hammerton, G., Zammit, S., Potter, R., Thapar, A. and Collishaw, S. 2014. Validation of a composite of suicide items from the Mood and Feelings Questionnaire (MFQ) in offspring of recurrently depressed parents. Psychiatry Research 216(1), pp. 82-88. (10.1016/j.psychres.2014.01.040)
Hart, A. B. et al. 2014. Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder. Proceedings of the National Academy of Sciences 111(16), pp. 5968-5973. (10.1073/pnas.1318810111)
Eyre, O. and Thapar, A. 2014. Common adolescent mental disorders: transition to adulthood. The Lancet 383(9926), pp. 1366. (10.1016/S0140-6736(13)62633-1)
Rutter, M. and Thapar, A. 2014. Genetics of autism spectrum disorders. In: Volkmar, F. R. et al. eds. Handbook of Autism and Pervasive Developmental Disorders., Vol. 1. Hoboken, New Jersey: John Wiley & Sons Inc, pp. 411-423.
Cooper, M., Langley, K. and Thapar, A. 2014. Antenatal Acetaminophen use and attention-deficit/hyperactivity disorder. JAMA Pediatrics 168(4), pp. 306-307. (10.1001/jamapediatrics.2013.5292)
Langley, K. and Thapar, A. 2014. Commentary: Maternal pre-pregnancy BMI and offspring ADHD: a lesson in the importance of testing causal pathways. International Journal of Epidemiology 43(1), pp. 91-93. (10.1093/ije/dyt275)
Merwood, A. et al. 2014. Genetic associations between the symptoms of Aattention-deficit/hyperactivity disorder and emotional lability in child and adolescent twins. Journal of the American Academy of Child & Adolescent Psychiatry 53(2), pp. 209-220. (10.1016/j.jaac.2013.11.006)
Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. 2014. Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry 23(1), pp. 23-24. (10.1007/s00787-013-0398-6)
Niarchou, M., Zammit, S., van Goozen, S. H. M., Thapar, A., Tierling, H. M., Owen, M. J. and van den Bree, M. B. M. 2014. Psychopathology and cognition in children with 22q11.2 deletion syndrome. British Journal of Psychiatry 204(1), pp. 46-54. (10.1192/bjp.bp.113.132324)
Thapar, A. K. et al. 2014. Detecting recurrent major depressive disorder within primary care rapidly and reliably using short questionnaire measures. British Journal of General Practice (BJGP) 64(618), pp. e31-7. (10.3399/bjgp14X676438)
Martin, J., Hamshere, M. L., O'Donovan, M. C., Rutter, M. and Thapar, A. 2014. Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders 44(1), pp. 204-215. (10.1007/s10803-013-1865-0)
Harold, G. T., Leve, L. D., Kim, H. K., Mahedy, L., Gaysina, D., Thapar, A. and Collishaw, S. 2014. Maternal caregiving and girls' depressive symptom and antisocial behavior trajectories: An examination among high-risk youth. Development and Psychopathology 26(4pt2), pp. 1461-1475. (10.1017/S095457941400114X)
Hammerton, G., Thapar, A. and Thapar, A. K. 2014. Association between obesity and depressive disorder in adolescents at high risk for depression. International Journal of Obesity 38, pp. 513-519. (10.1038/ijo.2013.133)

2013

Lewis, K. J. et al. 2013. The Depression impairment scale for parents (DISP): A new scale for the measurement of impairment in depressed parents. Psychiatry Research 210(3), pp. 1184-1190. (10.1016/j.psychres.2013.08.001)
Rawal, A., Collishaw, S., Thapar, A. and Rice, F. 2013. A direct method of assessing underlying cognitive risk for adolescent depression. Journal of Abnormal Child Psychology 41(8), pp. 1279-1288. (10.1007/s10802-013-9760-x)
Harold, G. T. et al. 2013. Biological and rearing mother influences on child ADHD symptoms: revisiting the developmental interface between nature and nurture. Journal of Child Psychology and Psychiatry 54(10), pp. 1038-46. (10.1111/jcpp.12100)
Ahuja, A., Martin, J., Langley, K. and Thapar, A. 2013. Intellectual disability in children with attention deficit hyperactivity disorder. The Journal of Pediatrics 163(3), pp. 890-895.e1. (10.1016/j.jpeds.2013.02.043)
Mars, B. et al. 2013. Specific parental depression symptoms as risk markers for new-onset depression in high-risk offspring. The Journal of Clinical Psychiatry 74(9), pp. 925-931. (10.4088/JCP.12m08152)
Lee, S. et al. 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45(9), pp. 984-994. (10.1038/ng.2711)
Hammerton, G., Harold, G. T., Thapar, A. K. and Thapar, A. 2013. Depression and blood pressure in high-risk children and adolescents: an investigation using two longitudinal cohorts. British Medical Journal Open 3(9), pp. e003206. (10.1136/bmjopen-2013-003206)
Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
Thapar, A. and Cooper, M. 2013. Copy number variation: What is it and what has it told us about child psychiatric disorders?. Journal of the American Academy of Child & Adolescent Psychiatry 52(8), pp. 772-774. (10.1016/j.jaac.2013.05.013)
Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
van den Bree, M. B., Miller, G., Mansell, E., Thapar, A., Flinter, F. and Owen, M. J. 2013. The internet is parents' main source of information about psychiatric manifestations of 22q11.2 deletion syndrome (22q11.2DS). European Journal of Medical Genetics 56(8), pp. 439-441. (10.1016/j.ejmg.2013.05.001)
Yang, L. et al. 2013. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162(5), pp. 419-430. (10.1002/ajmg.b.32169)
Sellers, R. et al. 2013. Maternal depression and co-occurring antisocial behaviour: testing maternal hostility and warmth as mediators of risk for offspring psychopathology. Journal of Child Psychology and Psychiatry 55(2), pp. 112-120. (10.1111/jcpp.12111)
Agha, S. S., Zammit, S., Thapar, A. and Langley, K. 2013. Are parental ADHD problems associated with a more severe clinical presentation and greater family adversity in children with ADHD?. European Child & Adolescent Psychiatry 22(6), pp. 369-377. (10.1007/s00787-013-0378-x)
Thapar, A., Langley, K. and Muñoz-Solomando, A. 2013. The ADHD debate: being mindful of complexity and wary of reductionist explanations and polarization: Commentary on 'A social relational critique of the biomedical definition and treatment of ADHD; ethical, practical and political implications'. Journal of Family Therapy 35(2), pp. 219-223. (10.1111/j.1467-6427.2012.00608.x)
Smoller, J. W. et al. 2013. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet 381(9875), pp. 1371-1379. (10.1016/S0140-6736(12)62129-1)
Telford, C., Green, C., Logan, S., Langley, K., Thapar, A. and Ford, T. 2013. Estimating the costs of ongoing care for adolescents with attention-deficit hyperactivity disorder. Social Psychiatry and Psychiatric Epidemiology 48(2), pp. 337-344. (10.1007/s00127-012-0530-9)
Harold, G. T. et al. 2013. The nature of nurture: Disentangling passive genotype-environment correlation from family relationship influences on children's externalizing problems [Article]. Journal of Family Psychology 27(1), pp. 12-21. (10.1037/a0031190)
Rice, F., Lewis, G., Harold, G. T. and Thapar, A. 2013. Examining the role of passive gene-environment correlation in childhood depression using a novel genetically sensitive design. Development and Psychopathology 25(1), pp. 37-50. (10.1017/S0954579412000880)
Rawal, A., Collishaw, S., Thapar, A. and Rice, F. 2013. 'The risks of playing it safe': a prospective longitudinal study of response to reward in the adolescent offspring of depressed parents. Psychological Medicine 43(1), pp. 27-38. (10.1017/S0033291712001158)
Thapar, A., Cooper, M., Eyre, O. and Langley, K. 2013. Practitioner review: what have we learnt about the causes of ADHD?. Journal of Child Psychology and Psychiatry 54(1), pp. 3-16. (10.1111/j.1469-7610.2012.02611.x)

2012

Lewis, K. J. et al. 2012. Do parents know best? Parent-reported vs. child-reported depression symptoms as predictors of future child mood disorder in a high-risk sample. Journal of Affective Disorders 141(2-3), pp. 233-236. (10.1016/j.jad.2012.03.008)
Cooper, M. and Thapar, A. 2012. Shared biological risks that influence brain and behaviour. Archives of Disease in Childhood 97(12), pp. 1011-1012. (10.1136/archdischild-2012-302461)
Harold, G. T., Elam, K. K., Lewis, G., Rice, F. and Thapar, A. 2012. Interparental conflict, parent psychopathology, hostile parenting, and child antisocial behavior: Examining the role of maternal versus paternal influences using a novel genetically sensitive research design. Development and Psychopathology 24(4), pp. 1283-1295. (10.1017/S0954579412000703)
Sellers, R. et al. 2012. Risk of psychopathology in adolescent offspring of mothers with psychopathology and recurrent depression. British Journal of Psychiatry 202(2), pp. 108-114. (10.1192/bjp.bp.111.104984)
Langley, K., Heron, J., Davey-Smith, G. and Thapar, A. 2012. Maternal and paternal smoking during pregnancy and risk of ADHD symptoms in offspring: testing for intrauterine effects. American Journal of Epidemiology 176(3), pp. 261-268. (10.1093/aje/kwr510)
Bevan-Jones, R., Thapar, A. K. and Thapar, A. 2012. Review: psychological and educational interventions may reduce risk of depressive disorders in children and adolescents. Evidence-Based Mental Health 15(3), pp. 82. (10.1136/ebmental-2012-100681)
Potter, R. et al. 2012. Missed opportunities: mental disorder in children of parents with depression. British Journal of General Practice (BJGP) 62(600), pp. e487-e493. (10.3399/bjgp12X652355)
Thapar, A., Collishaw, S., Pine, D. S. and Thapar, A. K. 2012. Depression in adolescence. The Lancet 379(9820), pp. 1056-1067. (10.1016/S0140-6736(11)60871-4)
Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169(2), pp. 195-204. (10.1176/appi.ajp.2011.11060822)
Lewis, G., Collishaw, S., Harold, G. T., Rice, F. and Thapar, A. 2012. Maternal depression and child and adolescent depression symptoms: an exploratory test for moderation by CRHR1, FKBP5 and NR3C1 gene variants. Behavior Genetics 42(1), pp. 121-132. (10.1007/s10519-011-9482-1)
Bevan Jones, R., Thapar, A., Lewis, G. and Zammit, S. 2012. The association between early autistic traits and psychotic experiences in adolescence. Schizophrenia Research 135(1-3), pp. 164-169. (10.1016/j.schres.2011.11.037)
Mars, B. et al. 2012. Offspring of parents with recurrent depression: which features of parent depression index risk for offspring psychopathology?. Journal of affective disorders 136(1-2), pp. 44-53. (10.1016/j.jad.2011.09.002)

2011

Shelton, K. H., Collishaw, S., Rice, F., Harold, G. T. and Thapar, A. 2011. Using a genetically informative design to examine the relationship between breastfeeding and childhood conduct problems. European Child and Adolescent Psychiatry 20(11-12), pp. 571-579. (10.1007/s00787-011-0224-y)
Hinney, A. et al. 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 888-897. (10.1002/ajmg.b.31246)
Hay, D. F. et al. 2011. Known risk factors for violence predict 12-month-old infants' aggressiveness with peers. Psychological Science 22(9), pp. 1205-1211. (10.1177/0956797611419303)
Harold, G. T., Rice, F., Hay, D. F., Boivin, J., van den Bree, M. B. and Thapar, A. 2011. Familial transmission of depression and antisocial behavior symptoms: Disentangling the contribution of inherited and environmental factors and testing the mediating role of parenting. Psychological Medicine 41(6), pp. 1175-1185. (10.1017/S0033291710001753)
Lewis, G., Rice, F., Harold, G. T., Collishaw, S. and Thapar, A. 2011. Investigating environmental links between parent depression and child depressive/anxiety symptoms using an assisted conception design. Journal of the American Academy of Child & Adolescent Psychiatry 50(5), pp. 451-459. (10.1016/j.jaac.2011.01.015)
Thapar, A. and Munoz-Solomando, A. 2011. Attention-deficit hyperactivity disorder. In: Skuse, D. et al. eds. Child Psychology and Psychiatry: Frameworks for Practice, Second Edition. John Wiley & Sons Ltd, pp. 153-160.
Stergiakouli, E. et al. 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10(3), pp. 334-344. (10.1111/j.1601-183x.2010.00672.x)
Williams, N. M., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2011. Structural variations in attention-deficit hyperactivity disorder - Authors' reply [Letter]. The Lancet 377(9763), pp. 378. (10.1016/S0140-6736(11)60121-9)
Thapar, A., Cooper, M., Jefferies, R. and Stergiakouli, E. 2011. What causes attention deficit hyperactivity disorder?. Archives of Disease in Childhood 97(3), pp. 260-265. (10.1136/archdischild-2011-300482)
Hassan, A., Agha, S. S., Langley, K. and Thapar, A. 2011. Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorder. British Journal of Psychiatry 198(3), pp. 195-198. (10.1192/bjp.bp.110.078741)
Owen, M. J., O'Donovan, M. C., Thapar, A. and Craddock, N. J. 2011. Neurodevelopmental hypothesis of schizophrenia. British Journal of Psychiatry 198(3), pp. 173-175. (10.1192/bjp.bp.110.084384)
Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.

2010

Langley, K., Heron, J., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2010. Genotype link with extreme antisocial behavior: The contribution of cognitive pathways. Archives of General Psychiatry 67(12), pp. 1317-1323. (10.1001/archgenpsychiatry.2010.163)
Craddock, N. J., Kerr, M. P. and Thapar, A. 2010. What is the core expertise of the psychiatrist?. The Psychiatrist 34(11), pp. 457-460. (10.1192/pb.bp.110.030114)
Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376(9750), pp. 1401-1408. (10.1016/S0140-6736(10)61109-9)
Stergiakouli, E. and Thapar, A. 2010. Fitting the pieces together: current research on the genetic basis of attention-deficit/hyperactivity disorder (ADHD). Neuropsychiatric Disease and Treatment, pp. 551-560. (10.2147/NDT.S11322)
Thapar, A. et al. 2010. Response to: testing the association between smoking in pregnancy and attention-deficit/hyperactivity disorder in a novel design [Letter]. Biological psychiatry 68(4), pp. e13-e14. (10.1016/j.biopsych.2010.01.032)
Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196(3), pp. 235-240. (10.1192/bjp.bp.109.066274)
Rice, F., Harold, G. T., Boivin, J., van den Bree, M. B., Hay, D. F. and Thapar, A. 2010. The links between prenatal stress and offspring development and psychopathology: Disentangling environmental and inherited influences. Psychological Medicine 40(2), pp. 335-345. (10.1017/S0033291709005911)
Thapar, A., Collishaw, S., Potter, R. and Thapar, A. K. 2010. Managing and preventing depression in adolescents [Review]. British Medical Journal (BMJ) 340, pp. c209. (10.1136/bmj.c209)
Hay, D. F. et al. 2010. Identifying early signs of aggression: psychometric properties of the cardiff infant contentiousness scale. Aggressive Behavior 36(6), pp. 351-357. (10.1002/ab.20363)
Rice, F. and Thapar, A. 2010. Estimating the relative contributions of maternal genetic, paternal genetic and intrauterine factors to offspring birth weight and head circumference. Early Human Development 86(7), pp. 425-432. (10.1016/j.earlhumdev.2010.05.021)
Neale, B. M. et al. 2010. Case-control genome-wide association study of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 906-920. (10.1016/j.jaac.2010.06.007)
Neale, B. M. et al. 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 884-897. (10.1016/j.jaac.2010.06.008)
Yan, T. C., McQuillin, A., Thapar, A., Asherson, P., Hunt, S. P., Stanford, S. and Gurling, H. 2010. NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. Journal of Psychopharmacology 24(1), pp. 27-38. (10.1177/0269881108100255)

2009

Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19(6), pp. 312-319. (10.1097/YPG.0b013e3283328df4)
Thapar, A. et al. 2009. Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel design. Biological Psychiatry 66(8), pp. 722-727. (10.1016/j.biopsych.2009.05.032)
Shelton, K. H., Boivin, J., Hay, D. F., van den Bree, M. B., Rice, F., Harold, G. T. and Thapar, A. 2009. Examining differences in psychological adjustment problems among children conceived by assisted reproductive technologies. International Journal of Behavioral Development 33(5), pp. 385-392. (10.1177/0165025409338444)
Boivin, J., Rice, F., Hay, D. F., Harold, G. T., Lewis, A., van den Bree, M. B. and Thapar, A. 2009. Associations between maternal older age, family environment and parent and child wellbeing in families using assisted reproductive techniques to conceive. Social Science & Medicine 68(11), pp. 1948-1955. (10.1016/j.socscimed.2009.02.036)
Goodwin, G., Jones, I. R. and Thapar, A. 2009. Evidence-based guidelines for treating bipolar disorder: revised second edition--recommendations from the British Association for Psychopharmacology. Journal of Psychopharmacology 23(4), pp. 346-388. (10.1177/0269881109102919)
Rice, F. and Thapar, A. 2009. Depression and anxiety in childhood and adolescence: developmental pathways, genes and environment. In: Kim, Y. ed. Handbook of Behavior Genetics. New York: Springer, pp. 379-396., (10.1007/978-0-387-76727-7_26)
Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
Rutter, M., Thapar, A. and Pickles, A. 2009. Gene-environment interactions: biologically valid pathway or artifact? [Response to an article]. Archives of General Psychiatry 66(12), pp. 1287-1289. (10.1001/archgenpsychiatry.2009.167)
Rice, F., Harold, G. T., Boivin, J., Hay, D. F., van den Bree, M. B. and Thapar, A. 2009. Disentangling prenatal and inherited influences in humans with an experimental design. Proceedings of the National Academy of Sciences of the United States of America 106(7), pp. 2464-2467. (10.1073/pnas.0808798106)
Lifford, K. J., Harold, G. T. and Thapar, A. 2009. Parent–child hostility and child ADHD symptoms: a genetically sensitive and longitudinal analysis. Journal of Child Psychology and Psychiatry 50(12), pp. 1468-1476. (10.1111/j.1469-7610.2009.02107.x)
Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
Craddock, N. J. et al. 2009. Dissecting the phenotype in genome-wide association studies of psychiatric illness (Editorial). British Journal of Psychiatry 195(2), pp. 97-99. (10.1192/bjp.bp.108.063156)
Thapar, A. and Rutter, M. 2009. Do prenatal risk factors cause psychiatric disorder? Be wary of causal claims (Editorial). British Journal of Psychiatry 195(2), pp. 100-101. (10.1192/bjp.bp.109.062828)
Thapar, A. and Lewis, G. 2009. Should we be rethinking how we assess and manage ADHD?. Journal of the American Academy of Child & Adolescent Psychiatry 48(11), pp. 1051-1052. (10.1097/CHI.0b013e3181ba3e20)

2008

Ford, T., Fowler, T. A., Langley, K., Whittinger, N. S. and Thapar, A. 2008. Five years on: public sector service use related to mental health in young people with ADHD or hyperkinetic disorder five years after diagnosis. Child and Adolescent Mental Health 13(3), pp. 122-129. (10.1111/j.1475-3588.2007.00466.x)
Thapar, A. and Stergiakouli, E. 2008. Genetic influences on the development of childhood psychiatric disorders. Psychiatry 7(7), pp. 277-281.
Shelton, K. H., Harold, G. T., Fowler, T. A., Rice, F., Neale, M. C., Thapar, A. and van den Bree, M. B. 2008. Parent-Child Relations, Conduct Problems and Cigarette Use in Adolescence: Examining the Role of Genetic and Environmental Factors on Patterns of Behavior. Journal of Youth and Adolescence 37(10), pp. 1216-1228. (10.1007/s10964-007-9254-7)
Caspi, A. et al. 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 65(2), pp. 203-210. (10.1001/archgenpsychiatry.2007.24)
Brookes, K. J. et al. 2008. Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 94-99. (10.1002/ajmg.b.30562)
Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
Lifford, K. J., Harold, G. T. and Thapar, A. 2008. Parent-child relationships and ADHD symptoms: a longitudinal analysis. Journal of Abnormal Child Psychology 36(2), pp. 285-296. (10.1007/s10802-007-9177-5)
Rutter, M. et al. eds. 2008. Rutter's child and adolescent psychiatry. 5th ed.. Malden, Mass.: Blackwell Pub.
Thapar, A. 2008. Genetics. In: Rutter, M. et al. eds. Rutter's child and adolescent psychiatry. 5th ed.. Malden, MA: Blackwell Publishers, pp. 339-358.
Thapar, A. and Owen, M. J. 2008. A framework for interpreting genome-wide association studies of psychiatric disorders. Molecular Psychiatry 14(1), pp. 10-17. (10.1038/mp.2008.126)
Thapar, A. 2008. An overview on the genetics of ADHD. Acta Psychologica Sinica 40(10), pp. 1088-1098. (10.3724/SP.J.1041.2008.01088)
Thapar, A. and Muñoz-Solomando, A. 2008. Attention deficit hyperactivity disorder. Psychiatry 7(8), pp. 340-344. (10.1016/j.mppsy.2008.05.010)
Harold, G. T., Shelton, K. H., Rice, F., Boivin, J., Hay, D. F., van den Bree, M. B. and Thapar, A. 2008. Disentangling genetic and environmental influences on children’s development: introducing a novel methodology. Acta Psychologica Sinica 40(10), pp. 1124-1134.

2007

Thapar, A., Langley, K., Owen, M. J. and O'Donovan, M. C. 2007. Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine 37(12), pp. 1681-1692. (10.1017/S0033291707000773)
Rice, F. et al. 2007. Genetic and environmental transmission of anxiety and depression in families using a novel design [Abstract]. Behavior Genetics 37(6), pp. 788-788. (10.1007/s10519-007-9169-9)
Thapar, A., Harold, G. T., Rice, F., Langley, K. and O'Donovan, M. C. 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19(4), pp. 989-1004. (10.1017/S0954579407000491)
Rice, F., Lifford, K. J., Thomas, H. V. and Thapar, A. 2007. Mental health and functional outcomes of maternal and adolescent reports of adolescent depressive symptoms. Journal of the American Academy of Child & Adolescent Psychiatry 46(9), pp. 1162-1170. (10.1097/chi.0b013e3180cc255f)
Rice, F., Jones, I. R. and Thapar, A. 2007. Impact of gestational distress and growth retardation on emotional problems in offspring - Reply [Letter]. Acta Psychiatrica Scandinavica 116(2), pp. 154-155. (10.1111/j.1600-0447.2007.01042.x)
Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry 7(1), pp. 26-26. (10.1186/1471-244X-7-26)
Fowler, T. A. et al. 2007. Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. Addiction 102(3), pp. 413-422. (10.1111/j.1360-0443.2006.01694.x)
Shelton, K. H., Lifford, K., Fowler, T., Rice, F., Harold, G. T., Thapar, A. and van den Bree, M. B. 2007. The association between conduct problems and the initiation and progression of marijuana use during adolescence: A genetic analysis across time. Behavior Genetics 37(2), pp. 314-325. (10.1007/s10519-006-9124-1)
Rice, F., Jones, I. R. and Thapar, A. 2007. The impact of gestational stress and prenatal growth on emotional problems in offspring: a review [Review]. Acta Psychiatrica Scandinavica 115(3), pp. 171-183. (10.1111/j.1600-0447.2006.00895.x)
Whittinger, N., Langley, K., Fowler, T., Thomas, H. V. and Thapar, A. 2007. Clinical precursors of adolescent conduct disorder in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 46(2), pp. 179-187. (10.1097/01.chi.0000246066.00825.53)
van den Bree, M. B. et al. 2007. The Cardiff Study of All Wales and North West of England Twins (CaStANET): A longitudinal research program of child and adolescent development. Twin Research and Human Genetics 10(1), pp. 13-23. (10.1375/twin.10.1.13)
Thapar, A. et al. 2007. Do intrauterine or genetic influences explain the foetal origins of chronic disease? A novel experimental method for disentangling effects. BMC Medical Research Methodology 7(1), pp. 25-32. (10.1186/1471-2288-7-25)
Fowler, T. et al. 2007. Genetic and environmental influences on the relationship between peer alcohol use and own alcohol use in adolescents. Addiction 102(6), pp. 894-903. (10.1111/j.1360-0443.2007.01824.x)
Thapar, A., Langley, K., Asherson, P. and Gill, M. 2007. Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. British Journal of Psychiatry 190(1), pp. 1-3. (10.1192/bjp.bp.106.027003)
Rice, F. et al. 2007. Agreement between maternal report and antenatal records for a range of pre and peri-natal factors: The influence of maternal and child characteristics. Early Human Development 83(8), pp. 497-504. (10.1016/j.earlhumdev.2006.09.015)
Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)

2006

Thapar, A. and Rice, F. 2006. Twin studies in pediatric depression. Child and Adolescent Psychiatric Clinics of North America 15(4), pp. 869-81. (10.1016/j.chc.2006.05.007)
Zammit, S. et al. 2006. Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia. Journal of Psychiatric Research 40(7), pp. 622-626. (10.1016/j.jpsychires.2005.05.006)
Rice, F., Harold, G. T. and Thapar, A. 2006. The effect of birth-weight with genetic susceptibility on depressive symptoms in childhood and adolescence. European Child & Adolescent Psychiatry 15(7), pp. 383-391. (10.1007/s00787-006-0545-4)
Fowler, T. A., Rice, F., Thapar, A. and Farmer, A. 2006. Relationship between disabling fatigue and depression in children: Genetic study. British Journal of Psychiatry 189(3), pp. 247-253. (10.1192/bjp.bp.105.011379)
Thapar, A., Langley, K., O'Donovan, M. C. and Owen, M. J. 2006. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 11(8), pp. 714-20. (10.1038/sj.mp.4001831)
Rice, F., Harold, G. T., Shelton, K. H. and Thapar, A. 2006. Family conflict interacts with genetic liability in predicting childhood and adolescent depression. Journal of the American Academy of Child and Adolescent Psychiatry 45(7), pp. 841-848. (10.1097/01.chi.0000219834.08602.44)
Thapar, A., van den Bree, M. B., Fowler, T., Langley, K. and Whittinger, N. 2006. Predictors of antisocial behaviour in children with attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 15(2), pp. 118-125. (10.1007/s00787-006-0511-1)
Thapar, A. 2006. Genetics and environment in ADHD. In: McCabe, J. et al. eds. Beyond Nature and Nurture in Psychiatry: Genes, the Environment and Their Interplay. European Foundation for Psychiatry at the Maudsley Abingdon: Informa Healthcare, pp. 79-86.

2005

Langley, K., Rice, F., van den Bree, M. B. and Thapar, A. 2005. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.. Minerva Pediatrica 57(6), pp. 359-371.
Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
Thapar, A., Roland, M. and Harold, G. T. 2005. Do depression symptoms predict seizure frequency--or vice versa?. Journal of Psychosomatic Research 59(5), pp. 269-274. (10.1016/j.jpsychores.2005.04.001)
Thapar, A., O'Donovan, M. C. and Owen, M. J. 2005. The genetics of attention deficit hyperactivity disorder. Human Molecular Genetics 14(2), pp. 275-282. (10.1093/hmg/ddi263)
Stevenson, J., Langley, K., Pay, H., Payton, A., Worthington, J., Ollier, W. and Thapar, A. 2005. Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. Journal of Child Psychology and Psychiatry 46(10), pp. 1081-1088. (10.1111/j.1469-7610.2005.01533.x)
Rice, F., Harold, G. T. and Thapar, A. 2005. The Link between depression in mothers and offspring: an extended twin analysis. Behavior Genetics 35(5), pp. 565-577. (10.1007/s10519-005-5432-0)
Ahuja, A., Thapar, A. and Owen, M. J. 2005. Genetics of mental retardation. Indian Journal of Medical Sciences 59(9), pp. 407-417. (10.4103/0019-5359.16820)
Goody, A. J., Rice, F., Boivin, J., Harold, G. T., Hay, D. F. and Thapar, A. 2005. Twins born following fertility treatment: implications for quantitative genetic studies. Twin Research and Human Genetics 8(4), pp. 337-345. (10.1375/twin.8.4.337)
Fowler, T., Duthie, P., Thapar, A. and Farmer, A. 2005. The definition of disabling fatigue in children and adolescents. BMC Family Practice 6, pp. 33. (10.1186/1471-2296-6-33)
Button, T. M., Thapar, A. and McGuffin, P. 2005. Relationship between antisocial behaviour, attention-deficit hyperactivity disorder and maternal prenatal smoking. British Journal of Psychiatry 187, pp. 155-160. (10.1192/bjp.187.2.155)
Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
Stevenson, J., Asherson, P., Hay, D., Levy, F., Swanson, J., Thapar, A. and Willcutt, E. 2005. Characterizing the ADHD phenotype for genetic studies. Developmental Science 8(2), pp. 115-121. (10.1111/j.1467-7687.2005.00398.x)
Turic, D., Williams, H., Langley, K., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2005. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B(1), pp. 64-67. (10.1002/ajmg.b.30123)
Kent, L. et al. 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10(10), pp. 939-943. (10.1038/sj.mp.4001696)

2004

Rice, F., van den Bree, M. B. and Thapar, A. 2004. A population-based study of anxiety as a precursor for depression in childhood and adolescence. BMC Psychiatry 4, article number: 43. (10.1186/1471-244X-4-43)
Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
Rice, F., Goody, A. J., Boivin, J., Hay, D. F., Harold, G. T. and Thapar, A. 2004. A novel method for disentangling the effects of genes, intrauterine and environmental risk factors [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 116-117. (10.1002/ajmg.b.30101)
Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
Farmer, A., Fowler, T., Scourfield, J. and Thapar, A. 2004. Prevalence of chronic disabling fatigue in children and adolescents. The British Journal of Psychiatry 184(6), pp. 477-481. (10.1192/bjp.184.6.477)
Turic, D., Langley, K., Kirov, G., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2004. Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD. American Journal of Medical Genetics 127B(1), pp. 68-72. (10.1002/ajmg.b.20173)
Lowe, N. et al. 2004. Joint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes. American Journal of Human Genetics 74(2), pp. 348-356. (10.1086/381561)
Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
Holmes, J. et al. 2004. The Child Attention-Deficit Hyperactivity Disorder Teacher Telephone Interview (CHATTI): reliability and validity. British Journal of Psychiatry 184(1), pp. 74-78. (10.1192/bjp.184.1.74)
McGuffin, P. and Thapar, A. 2004. Postgenomic psychiatry: Great hopes or great hype?. Current Psychiatry Reports 6(2), pp. 75-76. (10.1007/s11920-004-0043-7)
Thapar, A. and Holmes, J. 2004. Genetics and juvenile antisocial behaviour. In: Bailey, S. and Dolan, M. eds. Adolescent Forensic Psychiatry., Vol. 1. London: Hodder Education, pp. 87-96.
Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)

2003

Thapar, A., Boivin, J., Harold, G. T., Hay, D. F., Rice, F. and Goody, A. J. 2003. A novel method for disentangling the effects of genes, intrauterine, and environmental risk factors [Abstract]. Behavior Genetics 33(6), pp. 721-721. (10.1023/A:1026187215665)
Ivanov, D. et al. 2003. Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis: Molecular genetic study. The British Journal of Psychiatry 183(5), pp. 409-413. (10.1192/bjp.183.5.409)
Thapar, A. et al. 2003. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. American Journal of Psychiatry 160(11), pp. 1985-1989. (10.1176/appi.ajp.160.11.1985)
Thapar, A. et al. 2003. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. American Journal of Psychiatry 160(11), pp. 1985-1989. (10.1176/appi.ajp.160.11.1985)
Button, T. and Thapar, A. 2003. Maternal smoking during pregnancy and antisocial outcomes in young people. Behavior Genetics 33(6), pp. 699-699.
Rice, F., Fowler, T., Scourfield, J. and Thapar, A. 2003. Anxiety and depression in childhood and adolescence: Developmental pathways, genes, and environment. Behavior Genetics 33(6), pp. 715-715.
Rice, F., Harold, G. T. and Thapar, A. 2003. The transmission of depressive symptoms from mother to child: Genetic and environmental pathways. Behavior Genetics 33(6), pp. 716-716.
Scourfield, J., Rice, F., Thapar, A., Harold, G. T., Martin, N. and McGuffin, P. 2003. Depressive symptoms in children and adolescents: Changing etiological influences with development. Behavior Genetics 33(6), pp. 718-719.
Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
Thapar, A. et al. 2003. Maternal smoking in pregnancy and attention deficit hyperactivity disorder symptoms in offspring. Behavior Genetics 33(6), pp. 720-721.
Rice, F., Harold, G. T. and Thapar, A. 2003. Negative life events as an account of age-related differences in the genetic aetiology of depression in childhood and adolescence. Journal of Child Psychology and Psychiatry 44(7), pp. 977-987. (10.1111/1469-7610.00182)
Scourfield, J., Rice, F., Thapar, A., Harold, G. T., Martin, N. and McGuffin, P. 2003. Depressive symptoms in children and adolescents: changing aetiological influences with development. Journal of Child Psychology and Psychiatry 44(7), pp. 968-976. (10.1111/1469-7610.00181)
Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
Williams, H. J. et al. 2003. Association between PRODH and schizophrenia is not confirmed. Molecular Psychiatry 8(7), pp. 644-645. (10.1038/sj.mp.4001276)
Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13(2), pp. 107-110. (10.1097/01.ypg.0000056177.32550.a5)
Thapar, A. K. and Thapar, A. 2003. Attention-deficit hyperactivity disorder.. British Journal of General Practice 53(488), pp. 225-230.
Lawson, D. C. et al. 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B(1), pp. 84-89. (10.1002/ajmg.b.10002)
Thapar, A. 2003. Attention deficit hyperactivity disorder: new genetic findings, new directions. In: Plomin, R. et al. eds. Behavioral Genetics in the Postgenomic Era. Washington, DC: American Psychological Association, pp. 445-462.

2002

Holmes, J., Hever, T., Hewitt, L., Ball, C., Taylor, E., Rubia, K. and Thapar, A. 2002. A pilot twin study of psychological measures of attention deficit hyperactivity disorder. Behavior Genetics 32(6), pp. 389-395. (10.1023/A:1020846426166)
Rice, F., Harold, G. T. and Thapar, A. 2002. Assessing the effects of age, sex and shared environment on the genetic aetiology of depression in childhood and adolescence. Journal of Child Psychology and Psychiatry 43(8), pp. 1039-1051. (10.1111/1469-7610.00231)
Barkley, R. A. et al. 2002. International consensus statement on ADHD. January 2002. [Comment]. Clinical Child and Family Psychology Review 5(2), pp. 89-111.
Thapar, A. 2002. Genes and environment in ADHD. European Psychiatry 17, pp. 30S-30S.
Thapar, A. K. and Thapar, A. 2002. Is primary care ready to take on Attention Deficit Hyperactivity Disorder?. BMC Family Practice 3, pp. 7-7. (10.1186/1471-2296-3-7)
Rice, F., Harold, G. T. and Thapar, A. 2002. The genetic aetiology of childhood depression: a review. Journal of Child Psychology and Psychiatry 43(1), pp. 65-79. (10.1111/1469-7610.00004)
Thapar, A. and Scourfield, J. 2002. Childhood disorders. In: McGuffin, P., Owen, M. J. and Gottesman, I. I. eds. Psychiatric Genetics and Genomics. Oxford Medical Publications Oxford: Oxford University Press, pp. 147-181.
Thapar, A. and Clayton-Smith, J. 2002. Genetics of mental retardation. In: McGuffin, P., Owen, M. J. and Gottesman, I. I. eds. Psychiatric Genetics and Genomics. Oxford Medical Publications Oxford: Oxford University Press, pp. 113-128.
McGuffin, P., Moffitt, T. and Thapar, A. 2002. Personality disorders. In: McGuffin, P., Owen, M. J. and Gottesman, I. I. eds. Psychiatric Genetics and Genomics. Oxford Medical Publications Oxford: Oxford University Press, pp. 183-210.
Thapar, A. and O'Donovan, M. C. 2002. Neurogenetics. In: D'haenen, H., den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley, pp. 167-180., (10.1002/0470854871.chxii)
West, A. et al. 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7(9), pp. 962-966. (10.1038/sj.mp.4001129)
Holmes, J. et al. 2002. Association of DRD4 in children with ADHD and comorbid conduct problems. American Journal of Medical Genetics 114(2), pp. 150-153. (10.1002/ajmg.10149)
Hawi, Z. et al. 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Molecular Psychiatry 7(7), pp. 718-725. (10.1038/sj.mp.4001048)

2001

Payton, A. et al. 2001. Susceptibility genes for a trait measure of attention deficit hyperactivity disorder: a pilot study in a non-clinical sample of twins. Psychiatry Research 105(3), pp. 273 -278. (10.1016/S0165-1781(01)00342-0)
Rice, F., Harold, G. T. and Thapar, A. 2001. Extreme depressive symptoms in children and adolescents. Behavior Genetics 31(5), pp. 467-467., article number: PMID: 15641870.
2001. Evidence of association between DRD4 and ADHD with conduct disturbance. Presented at: Behavior Genetics Association Meeting, Cambridge, 11 July 2001 Presented at Thapar, A. et al. eds.Behavior Genetics, Vol. 31. Behavior Genetics Association Meeting Abstracts Vol. 5. Springer Verlag pp. 470-471.
Thapar, A., Harrington, R. and McGuffin, P. 2001. Examining the comorbidity of ADHD related behaviours and conduct problems using a twin study design. British Journal of Psychiatry 179(3), pp. 224-229. (10.1192/bjp.179.3.224)
Payton, A. et al. 2001. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. Neuroscience Letters 105(5), pp. 464-470. (10.1002/ajmg.1407)
Thapar, A. and Holmes, J. 2001. Genes really do matter. The Psychologist 14(3), pp. 146-147.
Kent, L. et al. 2001. No association between CHRNA7 microsatellite markers and attention-deficit hyperactivity disorder. American Journal of Medical Genetics 105(8), pp. 686-689. (10.1002/ajmg.1553)

2000

Thapar, A., Harrington, R., Ross, K. and McGuffin, P. 2000. Does the definition of ADHD affect heritability?. Journal of the American Academy of Child & Adolescent Psychiatry 39(12), pp. 1528-1536. (10.1097/00004583-200012000-00015)
Holmes, J. et al. 2000. A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder. Molecular Psychiatry 5(5), pp. 523-530. (10.1038/sj.mp.4000751)
Kent, L. et al. 2000. Nicotinic acetylcholine receptor 7 subunit gene and attention deficit hyperactivity disorder.. American Journal of Medical Genetics 96(4), pp. 490-490.
Payton, A. et al. 2000. A family based candidate gene association study of Attention Deficit Hyperactivity Disorder. American Journal of Medical Genetics 96(4), pp. 489-489.
Thapar, A., Harrington, R. and McGuffin, P. 2000. Examining the genetic basis of ADHD related behaviours and conduct problems. American Journal of Medical Genetics 96(4), pp. 470-470.

1999

Thapar, A., Harrington, R. and McGuffin, P. 1999. Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design. Br J Psych 2001(Sept), pp. 179:224-229., article number: 11532799. (10.1016/j.neulet.2007.12.003)
Thapar, A. and Barrett, J. 1999. Thapar and barrett reply. Molecular Psychiatry 4(5), pp. 413-414. (10.1038/sj.mp.4000596)
Thapar, A. and Barrett, J. 1999. Sampling and analytic considerations in molecular genetics studies of ADHD. The advantages of predicting phenotype from genotype in ADHD research - Thapar and Barrett reply. Molecular Psychiatry 4(5), pp. 413-414.
Thapar, A., Harrington, R., Ross, K. and McGuffin, P. 1999. Defining attention deficit hyperactivity disorder: A genetic perspective.. Molecular Psychiatry 4, pp. S52-S52.
Thapar, A. et al. 1999. A quantitative trait loci study of attention deficit hyperactivity disorder. Molecular Psychiatry 4, pp. S52-S53.
Thapar, A., Holmes, J., Poulton, K. and Harrington, R. 1999. Genetic basis of attention deficit and hyperactivity. British Journal of Psychiatry 174, pp. 105-111. (10.1192/bjp.174.2.105)

1998

Thapar, A. and McGuffin, P. 1998. Validity of the shortened Mood and Feelings Questionnaire in a community sample of children and adolescents: a preliminary research note. Psychiatry Research 81(2), pp. 259-268. (10.1016/S0165-1781(98)00073-0)
Poulton, K. et al. 1998. A molecular genetic study of hyperkinetic disorder/attention deficit hyperactivity disorder. American Journal of Medical Genetics 81(6), pp. 458-458.
Thapar, A., Harold, G. T. and McGuffin, P. 1998. Life events and depressive symptoms in childhood--shared genes or shared adversity? A research note.. Journal of Child Psychology and Psychiatry 39(8), pp. 1153-1158. (10.1111/1469-7610.00419)
Thapar, A. 1998. Attention deficit hyperactivity disorder: unravelling the molecular genetics. Molecular Psychiatry 3(5), pp. 370-372. (10.1038/sj.mp.4000452)
Thapar, A. and McGuffin, P. 1998. A twin study of depressive symptoms in childhood. British Journal of Psychiatry 165(2), pp. 259-265. (10.1192/bjp.165.2.259)
Thapar, A. and McGuffin, P. 1998. Genetics and learning disability. In: Kerr, M. P. ed. Innovations in Health Care for People with Intellectual Disabilites. Lisieux Hall Publications
Thapar, A. 1998. Behavioural phenotypes. Psychological Medicine 28(2), pp. 493-494.
McGuffin, P. and Thapar, A. 1998. Genetics and Antisocial Personality Disorder. In: Millon, T. et al. eds. Psychopathy: Antisocial, Criminal and Violent Behavior. New York: The Guilford Press, pp. 215-230.

1997

Scourfield, J., McGuffin, P. and Thapar, A. 1997. Genes and social skills. Bioessays 19(12), pp. 1125-1127. (10.1002/bies.950191212)
Thapar, A., Harrington, R. and McGuffin, P. 1997. A genetic study of hyperactivity and related traits. American Journal of Medical Genetics 74(6), pp. 571-572.
Bond, L., Kerr, M. P., Dunstan, F. D. J. and Thapar, A. 1997. Attitudes of general practitioners towards health care for people with intellectual disability and the factors underlying these attitudes. Journal of Intellectual Disability Research 41(5), pp. 391-400. (10.1111/j.1365-2788.1997.tb00726.x)
Thapar, A. and McGuffin, P. 1997. Anxiety and depressive symptoms in childhood--a genetic study of comorbidity. Journal of Child Psychology and Psychiatry 38(6), pp. 651-656. (10.1111/j.1469-7610.1997.tb01692.x)
Thapar, A. and McGuffin, P. 1997. Anxiety and depressive symptoms in childhood - a genetic study of comorbidity. Journal of Child Psychology and Psychiatry 38(6), pp. 651-656. (10.1111/j.1469-7610.1997.tb01692)
Thapar, A. and McGuffin, P. 1997. Genetic basis of bad behaviour in adolescents. The Lancet 350(9075), pp. 411-412. (10.1016/S0140-6736(05)64134-7)

1996

Thapar, A. and McGuffin, P. 1996. A twin study of antisocial and neurotic symptoms in childhood. Psychological Medicine 26(6), pp. 1111-1118. (10.1017/S0033291700035832)
Thapar, A. and McGuffin, P. 1996. The genetic etiology of childhood depressive symptoms: A developmental perspective. Development and Psychopathology 8(4), pp. 751-760.
Thapar, A. and McGuffin, P. 1996. Genetic influences on life events in childhood. Psychological Medicine 26(4), pp. 813-820. (10.1017/S0033291700037831)
Kerr, M. . P., Dunstan, F. D. J. and Thapar, A. 1996. Attitudes of general practitioners to caring for people with learning disability. British Journal of General Practice 46(403), pp. 92-94.

1995

Thapar, A., Hervas, A. and McGuffin, P. 1995. Childhood hyperactivity scores are highly heritable and show sibling competition effects: twin study evidence. Behavior Genetics 25(6), pp. 537-544. (10.1007/BF02327577)
Thapar, A. and McGuffin, P. 1995. Are anxiety symptoms in childhood heritable?. Journal of Child Psychology and Psychiatry 36(3), pp. 439-447. (10.1111/j.1469-7610.1995.tb01301.x)

1994

Thapar, A., Gottesman, I. I., Owen, M. J., O'Donovan, M. C. and McGuffin, P. 1994. The genetics of mental retardation. The British Journal of Psychiatry 164(6), pp. 747. (10.1192/bjp.164.6.747)
McGuffin, P., Owen, M. J., O'Donovan, M. C., Thapar, A. and Gottesman, I. I. 1994. Seminars in psychiatric genetics. Gaskell, Royal College of Psychiatrists.

1993

Thapar, A. and McGuffin, P. 1993. Is personality-disorder inherited - an overview of the evidence. Journal of Psychopathology and Behavioral Assessment 15(4), pp. 325-345. (10.1007/BF00965036)
McGuffin, P. and Thapar, A. 1993. The genetics of personality disorder. In: Tyrer, P. and Stein, G. eds. Personality Disorder Reviewed. London: Gaskell, Royal College of Psychiatrists

1992

Thapar, A., Davies, G., Jones, T. and Kwett, M. 1992. Treatment of childhood encopresis - a review. Child: Care, Health and Development 18(6), pp. 343-353. (10.1111/j.1365-2214.1992.tb00364.x)
Thapar, A. K. and Thapar, A. 1992. Psychological sequelae of miscarriage: a controlled study using the general health questionnaire and the hospital anxiety and depression scale.. British Journal of General Practice (BJGP) 42(356), pp. 94-96.
McGuffin, P. and Thapar, A. 1992. The genetics of personality disorder. British Journal of Psychiatry 160(1), pp. 12-23. (10.1192/bjp.160.1.12)

1991

Thapar, A. and Ghosh, A. 1991. Non-attendance at a psychiatric clinic. British Journal of Psychiatry Bulletin 15(4), pp. 205-206. (10.1192/pb.15.4.205)

1989

Thapar, A. 1989. Psychiatric disorder in the medical profession.. British Journal of Hospital Medicine 42(6), pp. 480-483.

Overview of current research

My currently active grants and lead supervision roles all focus on neurodevelopmental disorders.
The first group of projects focus on ADHD. These include 2 Wellcome Trust post-doctoral fellowships on: i) sex differences, (ii) ADHD in 22q11 micro-deletion syndrome.
The second group of projects focus on a broader range of neurodevelopmental disorders.These include projects on (i) the natural history of childhood neurodevelopmental disorders from childhood to adult life and the contribution of early environmental exposures and genetic risks, (ii) the link between childhood neurodevelopmental disorder and adolescent mood disorder in ALSPAC and in a patient sample; (iii) the feasibility of a research unit in neurodevelopmental disorders for 5 to 8 year olds that interfaces with schools/education; (iv) genetic-environment interplay in relation to neurodevelopmental disorders in those born very preterm; (v) the impact of psychiatric risk alleles and environmental stressors on child/adolescent neurodevelopmental problems and trajectories in the ALSPAC and NCDS population cohorts.

Current Funded Projects

Wellcome Trust Collaborative Award: What happens to children with neurodevelopmental disorders when they grow up and why?
Waterloo Foundation Trust: Feasibility Study of a Neurodevelopmental Disorders Assessment Unit
MRC: Preterm birth and neuropsychiatric genetic risks
Wellcome Trust ISSF: Adult outcomes of childhood neurodevelopment problems
Wellcome Trust: Chronic Irritability in ADHD: Examining the clinical and genetic links with depression (Lead Supervisor for clinical PhD fellowship – Olga Eyre)
Wellcome Trust: Attention Deficit Hyperactivity Disorder (ADHD) inattention symptoms as antecedents of later psychotic outcomes in 22q11.2 Deletion Syndrome and the contribution of genetic risk (Lead supervisor for Sir Henry Wellcome Postdoctoral Fellowship for Maria Niarchou)
Wellcome Trust: A genetic study examining sex differences in the prevalence of ADHD and other neurodevelopmental disorders (Lead supervisor for Sir Henry Wellcome Postdoctoral Fellowship for Joanna Martin)
MRC: Identifying the impact of mental disorder risk alleles on childhood neurodevelopment
ESRC Utilising adoption-based research designs to examine the interplay between family relationship processes and child developmental outcomes.

Key selected papers

Riglin L, Collishaw S, Richards A, Thapar AK, Maughan B, O’Donovan M.C., Thapar A (2017) Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study, Lancet Psychiatry 4(1):57-62.
Riglin, L., Collishaw, S., Thapar, AK., Dalsgaard, S., Langley, K., Davey Smith, G., Stergiakouli , E., Maughan, B., O’Donovan, M. & Thapar, A. Association of genetic risk variants with Attention-Deficit/Hyperactivity Disorder trajectories in the general population. JAMA Psychiatry. 1;73(12):1285-1292
Thapar A, Cooper M, Rutter M (2016) Neurodevelopmental disorders: a personal view, The Lancet Psychiatry [Epub Ahead of Print]
Rice F, Sellers R, Hammerton G, Eyre O, Bevan-Jones R, Thapar AK, Collishaw S, Harold G, Thapar A, (2016) Antecedents of new-onset major depressive disorder in adolescence: a longitudinal familial high-risk study JAMA Psychiatry [Epub ahead of print]
Thapar A, Cooper M, (2016), Attention Deficit Hyperactivity Disorder, The Lancet 387(10024): 1240-50.
Thapar A, Martin J, Mick E, Arias Vásquez A, Langley K, Scherer SW, Schachar R, Crosbie J, Williams N, Franke B, Elia J, Glessner J, Hakonarson H, Owen MJ, Faraone SV, O'Donovan MC, Holmans P. (2015) Psychiatric gene discoveries shape evidence on ADHD's biology. Mol Psychiatry. [Epub ahead of print]
Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C., & Thapar A. (2014) Genetic risk for attention deficit hyperactivity disorder contributes to neurodevelopmental traits in the general population. Biol Psychiatry, 76(8):664-71.

Hamshere M, Langley K, Martin J, Agah S, Stergiakouli E, Anney, R, Buitelaar JK, Farone S, Lesch PK, Neale, B, Franke, B, Sonuga-Barke E, Asherson P, Merwood A, Kuntsi J, Medland S, Ripke S, Steinhausen H-C, Freitag C, Reif A, Renner T, Romanos M, Romanos J, Warnke A, Meyer J, Palmason H, Arias-Vásquez A, Rommelse N, Roeyers, H, Biederman J, Doyle A, Hakonarson, H, Rothenberger, A, Banaschewski T, Oades, R, McGough, J, Kent L, Williams N, Owen MJ, Holmans P, O’Donovan MC, Thapar A (2013). High loading of polygenic risk for ADHD in those with comorbid aggression, Am J Psychiatry,170(8):909-16

Langley K, Heron J, Smith GD, Thapar A. (2012). Maternal and Paternal Smoking During Pregnancy and Risk of ADHD Symptoms in Offspring: Testing for Intrauterine Effects.Am. J. Epidemiol. (2012) 176(3): 261-268

Stergiakouli E, Hamshere M, Holmans P, Langley K, Zaharieva I; decode Genetics; Psychiatric GWAS Consortium, Hawi Z, Kent L, Gill M, Williams N, Owen MJ, O’Donovan MC, Thapar A. (2012). Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. Am J Psychiatry. 169(2):186-94. .

Williams NM, Zaharieva I, Martin A, Langley K, Mantripragada K, Fossdal R, Steffansson H, Stefansson K, Magnssuon P, Gudmundsson OO, Gustafsson O, Holmans P, Owen MJ, O’Donovan MC, Thapar A. (2010). Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet. 376(9750): 1401-1408.

Langley K, Heron J, O’Donovan MC, Owen MJ, Thapar A. (2010) Genotype link with extreme antisocial behaviour: the contribution of cognitive pathways. Arch Gen Psychiatry. 67(12): 1317-1323.

Thapar A, Rice F, Hay D, Boivin J, Langley K, Van den Bree MB, Rutter M, Harold G.(2009) Prenatal smoking might not cause ADHD: evidence from a novel design. Biological Psychiatry. 66(8): 722-727.

Rice F, Harold GT, Boivin J, Hay D, Van den Bree MB, Thapar A. (2009) Disentangling prenatal and inherited influences in humans with an experimental design. Proceedings of the National Academy of Sciences. USA, 106 (7): 2464-2467.

Selected previous projects

Wellcome Trust Programme Grant. Identifying susceptibility genes for ADHD with antisocial behaviour as a covariate.
Wellcome Trust Project grant. Disentangling genetic, intrauterine and environmental influences on childhood psychopathology using a novel method.
Medical Research Council project grant. Antisocial behaviour in young people with ADHD: identifying risk pathways.
Action Medical Research project grant. Detecting chromosomal anomalies in children with ADHD and mental retardation using microarray based comparative genomic hybridisation.
The Economic and Social Research Council (ESRC) project grant. Family and genetic influences on children's psychological development.

Undergraduate teaching

Academic mentor for undergraduates
Lecture and examining on neurodevelopmental disorders, intercalated BSc Psychology
SSCs in child neurodevelopmental disorders

Postgraduate teaching

Lectures and placements

Wellcome Trust PhD programme: lecture on child and adolescent mental health
MRC Centre Summer school
MRC Centre and Wellcome Trust PhD programme: rotation placements in population health/neurodevelopmental disorders

Current PhD students

Olga Eyre, Wellcome Trust clinical research fellow

External mentorship

I am an Academy of Medical Sciences mentor for two clinician scientists

Public engagement

We have a track record of working with the media having worked with the Cardiff University Public engagement team (e.g. Cardiff Challenge), the UK Science Media Centre, contributed to and participated in television (a BBC Wales documentary, Breakfast TV and news items), radio (Radio 4 Today programme, national and local radio stations).

National and international web podcasts and films on ADHD include:

https://www.youtube.com/watch?v=OSBdjgNDAHE

http://ncmh.info/videos/adhd-facts-fiction/

http://ncmh.info/last-chance-saloon/

https://www.youtube.com/user/BBRFoundation/videos

Education and Qualifications

1995: PhD (Genetic Epidemiology/Psychiatry), University of Wales College of Medicine, Cardiff
1989: MRCPsych, Royal College of Psychiatrists, UK
1985: MBBCh (Medicine), Welsh National School of Medicine, Cardiff

Career overview

1999 - present: Cardiff University School of Medicine
2014 – 2017: Visiting Professor, School of Psychology, University of Sussex

Anrhydeddau a dyfarniadau

CBE for services to Child Psychiatry
Presidents Medal 2015, Royal College of Psychiatrists, UK for contribution to policy, public knowledge, education and meeting population and patient care needs
Ruane Prize 2015, Brain and Behavior Research Foundation, USA for outstanding Child & Adolescent Psychiatric research
Fellow of the Academy of Medical Sciences (FMedSci) 2011, UK
Fellow of the Learned Society of Wales 2011, Wales
Fellow of the Royal College of Psychiatrists, 1995, UK
Laughlin Prize 1989 Royal College of Psychiatrists, UK for highest marks and best recommendation in MRCPsych examinations
Maldwyn Catell Memorial Prize (Welsh Medical Council) awarded 1985 (medical school), Welsh National School of Medicine
Geraint Walters Prize in Haematology awarded 1985 (medical school), Welsh National School of Medicine

Aelodaethau proffesiynol

Academy of Medical Sciences

Safleoedd academaidd blaenorol

1996-1999: Senior Lecturer, Manchester University
1991-1995: MRC Clinical Research Fellow, University of Wales College of Medicine, Cardiff

Pwyllgorau ac adolygu

Selected panels, advisory and editorial boards

2016: Member of the American Psychiatric Association Review Committee on Neurodevelopmental Disorders [Intellectual Disability, Learning Disorders, Communication Disorders, Autism Spectrum Disorders, Motor Disorders, ADHD].
2015-present: Member of the Together for Children and Young People Expert Reference Group - A Welsh Assembly Government and CAMHS multi- agency Programme Board to drive forward the development and implementation of service improvement plans.
2014 – present: Associate Editor and member of the Editorial Board of the American Journal of Psychiatry
2014-present:Corresponding Member of the American Academy of Child and Adolescent Psychiatry
2014-present: The Lancet Psychiatry Advisory Board
2015:Wellcome Trust Public Health and Tropical Medicine Interview Committee Member
2013 – 2015: Member of the Academy of Medical Sciences Sectional Committee
2012 - 2016: Member of the Academy of Medical Sciences Academic Careers Committee
2011: Panel member for Evaluation of Biology, Medicine and Health in Norway (March)
2009: Autism Speaks - Grant Review Panel
2004 - 2007:Wellcome Trust Cognitive and Higher Systems Funding Committee
2001 - 2007:Secretary and treasurer of the UK Child Psychiatry Research Society

Child and adolescent/youth mental health from 0 to 25 years

Epidemiology/genetics

Research translation to Policy and Practice

2020 – 2022 Government Policy: Member of Welsh Health Collaborative’s Together for Children and Young People T4CYP (2) Neurodevelopmental Steering Group; Neurodiversity advisory panel; Early Help and Enhanced Support Work Stream

2020 – 2025 Board member for UK Patient Charity: ADHD Foundation

2021 – 2026 Member of European ADHD Guidelines Group (EAGG)

2016 Member of consultation panel for the National Institute for Health’s Research Development of a Ten Year Strategy f for Mental Health - Children and Young People.

2015 - 2019 Expert Reference Group member of Together for Children and Young People Expert Reference Group - A Welsh Assembly Government and CAMHS multi- agency Programme Board to drive forward the development and implementation of child and adolescent mental health service improvement plans in Wales

Other panel memberships and boards

Ruane Prize Committee, Brain & Behavior Research Foundation USA

The Lancet Psychiatry Journal Advisory Board

Associate Editor American Journal of Psychiatry

Member of the American Psychiatric Association Review Committee on Neurodevelopmental Disorders [Intellectual Disability, Learning Disorders, Communication Disorders, Autism Spectrum Disorders, Motor Disorders, ADHD].

Public engagement

We have a track record of working with the media on child and adolescent mental health, especially around ADHD.

I have worked with the Cardiff University Public engagement team (e.g. Cardiff Challenge), the UK Science Media Centre, contributed to and participated in television (a BBC Wales documentary, Breakfast TV and news items), radio (Radio 4 Today programme, national and local radio stations) on ADHD and adolescent depression.

National and international web podcasts and films on ADHD include:

Challenge Cardiff interview

ADHD Facts and Fiction (public lecture)

Last Chance Saloon (short film/documentary)

Ruane Prize winner (short film)

Darganfod y ffactorau risg genetig cyffredin cyntaf ar gyfer ADHD

27 November 2018

Gwobrau'n dathlu academyddion Caerdydd

18 May 2017

Yr Athro Anita Thapar

Trosolwyg

Cyhoeddiad

2023

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Articles

Book sections

Books

Conferences

Ymchwil

Overview of current research

Current Funded Projects

Key selected papers

Selected previous projects

Addysgu

Undergraduate teaching

Postgraduate teaching

Lectures and placements

Current PhD students

External mentorship

Public engagement

Bywgraffiad

Education and Qualifications

Career overview

Anrhydeddau a dyfarniadau

Aelodaethau proffesiynol

Safleoedd academaidd blaenorol

Pwyllgorau ac adolygu

Selected panels, advisory and editorial boards

Meysydd goruchwyliaeth

Ymgysylltu

Public engagement

Newyddion cysylltiedig

Darganfod y ffactorau risg genetig cyffredin cyntaf ar gyfer ADHD

Gwobrau'n dathlu academyddion Caerdydd

External profiles