![Matthew Tredwell](https://profiles-cardiff.imgix.net/attachments/1536?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Matthew Tredwell
Uwch Ddarlithydd mewn Cemeg Feddyginiaethol ac Uwch Gymrawd Ymchwilydd
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Grŵp Tredwell – meysydd ymchwil craidd
- cemeg organofluorine
- catalysis trawsnewid-metel
- synthesis radiocemegol
- Datblygiad radiotracer
- synthesis awtomataidd
- Cyfieithiad clinigol
Cyhoeddiad
2024
- Ortalli, S., Ford, J., Szpera, R., Stoessel, B., Trabanco, A. A., Tredwell, M. and Gouverneur, V. 2024. 18F-Difluoromethyl(ene) motifs via oxidative fluorodecarboxylation with [18F]Fluoride. Organic Letters 26(43), pp. 9368-9372. (10.1021/acs.orglett.4c03611)
- Ford, J., Ortalli, S., Chen, Z., Sap, J., Tredwell, M. and Gouverneur, V. 2024. Expedient access to 18F-fluoroheteroarenes via deaminative radiofluorination of aniline-derived pyridinium salts. Angewandte Chemie 63(26), article number: e202404945. (10.1002/anie.202404945)
- Ortalli, S., Ford, J., Trabanco, A. A., Tredwell, M. and Gouverneur, V. 2024. Photoredox nucleophilic (radio)fluorination of alkoxyamines. Journal of the American Chemical Society 146(17), pp. 11599-11604. (10.1021/jacs.4c02474)
2022
- Sap, J. B. I. et al. 2022. [18F]Difluorocarbene for Positron Emission Tomography. Nature 606, pp. 102-108. (10.1038/s41586-022-04669-2)
- Gendron, T. et al. 2022. Multi‐patient dose synthesis of [18F] Flumazenil via a copper‐mediated 18F‐fluorination. EJNMMI Radiopharmacy and Chemistry 7, article number: 5. (10.1186/s41181-022-00158-z)
2019
- Tredwell, M. 2019. Expanding the 18F-radiochemical space: synthesis and applications of 1,1-18F-difluorinated alkenes. SYNLETT 30(12), pp. 1371-1376. (10.1055/s-0037-1611764)
- Frost, A. B., Brambilla, M., Exner, R. and Tredwell, M. 2019. Synthesis and derivatization of 1,1-[18 F] difluorinated alkenes. Angewandte Chemie 131(2), pp. 482-486. (10.1002/ange.201810413)
- Frost, A. B., Brambilla, M., Exner, R. M. and Tredwell, M. 2019. Synthesis and derivatization of 1,1-[18 F] difluorinated alkenes. Angewandte Chemie International Edition 58(2), pp. 472-476. (10.1002/anie.201810413)
2018
- Verhoog, S. et al. 2018. 18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate. Journal of the American Chemical Society 140(5), pp. 1572-1575. (10.1021/jacs.7b10227)
2017
- Brambilla, M. and Tredwell, M. 2017. Palladium-catalyzed Suzuki-Miyaura cross-coupling of secondary α-(trifluoromethyl)benzyl tosylates. Angewandte Chemie 129(39), pp. 12143-12147. (10.1002/ange.201706631)
- Brambilla, M. and Tredwell, M. 2017. Palladium-catalyzed Suzuki-Miyaura cross-coupling of secondary α-(trifluoromethyl)benzyl tosylates. Angewandte Chemie International Edition 56(39), pp. 11981-11985. (10.1002/anie.201706631)
- Taylor, N. J. et al. 2017. Derisking the Cu-mediated 18F-fluorination of heterocyclic positron emission tomography radioligands. Journal of the American Chemical Society 139(24), pp. 8267-8276. (10.1021/jacs.7b03131)
2016
- Wilson, T. C., McSweeney, G., Preshlock, S., Verhoog, S., Tredwell, M., Cailly, T. and V{e, . 2016. Radiosynthesis of SPECT tracers via a copper mediated123I iodination of (hetero)aryl boron reagents. Chemical Communications 52(90), pp. 13277--13280. (10.1039/c6cc07417k)
- Preshlock, S. et al. 2016. Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications. Chemical Communications 52(54), pp. 8361-8364. (10.1039/c6cc03295h)
- Preshlock, S., Tredwell, M. and Gouverneur, V. 2016. 18F-labeling of arenes and aeteroarenes for applications in Positron Emission Tomography. Chemical Reviews 116(2), pp. 719-766. (10.1021/acs.chemrev.5b00493)
2015
- Buckingham, F. et al. 2015. Oxidative fluorination of N-arylsulfonamides. Journal of Fluorine Chemistry 180, pp. 33--39. (10.1016/j.jfluchem.2015.07.030)
- Khotavivattana, T. et al. 2015. 18F-Labeling of Aryl-SCF3, -OCF3and -OCHF2with [18F]Fluoride. Angewandte Chemie International Edition 54(34), pp. 9991-9995. (10.1002/anie.201504665)
- Verhoog, S. et al. 2015. Silver-mediated 18F-labeling of aryl-CF3 and aryl-CHF2 with 18F-fluoride. SYNLETT 27(1), pp. 25-28. (10.1055/s-0035-1560592)
- Hueting, R. et al. 2015. A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo.. Metallomics : integrated biometal science 7(5), pp. 795-804. (10.1039/c4mt00330f)
2014
- Tredwell, M. et al. 2014. A general copper-mediated nucleophilic18F fluorination of arenes. Angewandte Chemie International Edition 53(30), pp. 7751-7755. (10.1002/anie.201404436)
- Emer, E. et al. 2014. Diversity-oriented approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH-, and CF3(SCF3)CH-substituted arenes from 1-(diazo-2,2,2-trifluoroethyl)arenes.. Organic Letters 16(22), pp. 6004-6007. (10.1021/ol5030184)
- O'Brien, E. R. et al. 2014. Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 5(2), pp. 275-280. (10.2967/jnumed.113.127449)
- Anthony, D. C. et al. 2014. Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain.. Annals of Clinical and Translational Neurology 1(9), pp. 659-669. (10.1002/acn3.94)
- Hueting, R. et al. 2014. A comparison of the behavior of (64)Cu-acetate and (64)Cu-ATSM in vitro and in vivo.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 55(1), pp. 128-134. (10.2967/jnumed.113.119917)
2013
- Huiban, M. et al. 2013. A broadly applicable [18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging. Nature Chemistry 5(11), pp. 941-944. (10.1038/nchem.1756)
- Benedetto, E., Tredwell, M., Hollingworth, C., Khotavivattana, T., Brown, J. M. and Gouverneur, V. 2013. Regio- and stereoretentive synthesis of branched, linear (E)- and (Z)-allyl fluorides from allyl carbonates under Ir-catalysis. Chem. Sci. 4(1), pp. 89-96. (10.1039/c2sc21789a)
- Mizuta, S. et al. 2013. Catalytic decarboxylative fluorination for the synthesis of tri- and difluoromethyl arenes.. Organic Letters 15(11), pp. 2648-2651. (10.1021/ol4009377)
2012
- Benedetto, E., Keita, M., Tredwell, M., Hollingworth, C., Brown, J. M. and Gouverneur, V. 2012. Platinum-catalyzed substitution of allylic fluorides. Organometallics 31(4), pp. 1408-1416. (10.1021/om201029m)
- Tredwell, M. and Gouverneur, V. 2012. 1.5 fluorine in medicinal chemistry: importance of chirality. In: Comprehensive chirality., Vol. 1. Reference module in Chemistry, Molecular Sciences and Chemical Engineering London: Elsevier, pp. 70--85., (10.1016/b978-0-08-095167-6.00106-3)
- Gao, Z. et al. 2012. Metal-free oxidative fluorination of phenols with [18F]fluoride. Angewandte Chemie International Edition 51(27), pp. 6733-6737. (10.1002/anie.201201502)
- Tredwell, M. and Gouverneur, V. 2012. 18F labeling of arenes. Angewandte Chemie International Edition 51(46), pp. 11426-11437. (10.1002/anie.201204687)
2011
- Hollingworth, C. et al. 2011. Palladium-catalyzed allylic fluorination. Angewandte Chemie International Edition 50(11), pp. 2613-2617. (10.1002/anie.201007307)
- Kersemans, V. et al. 2011. Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation.. PLoS One 6(11), article number: e25911. (10.1371/journal.pone.0025911)
2010
- Tredwell, M. J., Gulias, M., Gaunt Bremeyer, N., Johansson, C. C. C., Collins, B. S. L. and Gaunt, M. J. 2010. Palladium(II)-catalyzed C-H bond arylation of electron-deficient arenes at room temperature. Angewandte Chemie International Edition 50(5), pp. 1076-1079. (10.1002/anie.201005990)
2008
- Tredwell, M., Luft, J. A. R., Schuler, M., Tenza, K., Houk, K. N. and Gouverneur, V. 2008. Fluorine-directed diastereoselective iodocyclizations. Angewandte Chemie International Edition 47(2), pp. 357-360. (10.1002/anie.200703465)
2007
- Kostov, G., Tredwell, M., Gouverneur, V. and Ameduri, B. 2007. Kinetics of radical copolymerization of [1-(fluoromethyl)vinyl]benzene with chlorotrifluoroethylene. Journal of Polymer Science Part A: Polymer Chemistry 45(17), pp. 3843-3850. (10.1002/pola.22134)
- Teare, H., Huguet, F., Tredwell, M., Thibaudeau, S., Luthra, S. and Gouveneur, V. 2007. A convergent approach for the synthesis of fluorinated sphingosine analogues. Archive for Organic Chemistry 2007(10), pp. 232-244. (10.3998/ark.5550190.0008.a14)
- Sawicki, M., Kwok, A., Tredwell, M. and Gouverneur, V. 2007. Single and double stereoselective fluorination of (E)-allylsilanes. Beilstein Journal of Organic Chemistry 3(1), pp. 34. (10.1186/1860-5397-3-34)
2006
- Tredwell, M. and Gouverneur, V. 2006. Electrophilic fluorination of organosilanes. Org. Biomol. Chem. 4(1), pp. 26-32. (10.1039/b513399h)
2005
- Tredwell, M., Tenza, K., Pacheco, M. C. and Gouverneur, V. 2005. Synthesis of novel enantiopure fluorinated building blocks from acyclic chiral allylsilanes.. Organic Letters 7(20), pp. 4495-4497. (10.1021/ol0518535)
Articles
- Ortalli, S., Ford, J., Szpera, R., Stoessel, B., Trabanco, A. A., Tredwell, M. and Gouverneur, V. 2024. 18F-Difluoromethyl(ene) motifs via oxidative fluorodecarboxylation with [18F]Fluoride. Organic Letters 26(43), pp. 9368-9372. (10.1021/acs.orglett.4c03611)
- Ford, J., Ortalli, S., Chen, Z., Sap, J., Tredwell, M. and Gouverneur, V. 2024. Expedient access to 18F-fluoroheteroarenes via deaminative radiofluorination of aniline-derived pyridinium salts. Angewandte Chemie 63(26), article number: e202404945. (10.1002/anie.202404945)
- Ortalli, S., Ford, J., Trabanco, A. A., Tredwell, M. and Gouverneur, V. 2024. Photoredox nucleophilic (radio)fluorination of alkoxyamines. Journal of the American Chemical Society 146(17), pp. 11599-11604. (10.1021/jacs.4c02474)
- Sap, J. B. I. et al. 2022. [18F]Difluorocarbene for Positron Emission Tomography. Nature 606, pp. 102-108. (10.1038/s41586-022-04669-2)
- Gendron, T. et al. 2022. Multi‐patient dose synthesis of [18F] Flumazenil via a copper‐mediated 18F‐fluorination. EJNMMI Radiopharmacy and Chemistry 7, article number: 5. (10.1186/s41181-022-00158-z)
- Tredwell, M. 2019. Expanding the 18F-radiochemical space: synthesis and applications of 1,1-18F-difluorinated alkenes. SYNLETT 30(12), pp. 1371-1376. (10.1055/s-0037-1611764)
- Frost, A. B., Brambilla, M., Exner, R. and Tredwell, M. 2019. Synthesis and derivatization of 1,1-[18 F] difluorinated alkenes. Angewandte Chemie 131(2), pp. 482-486. (10.1002/ange.201810413)
- Frost, A. B., Brambilla, M., Exner, R. M. and Tredwell, M. 2019. Synthesis and derivatization of 1,1-[18 F] difluorinated alkenes. Angewandte Chemie International Edition 58(2), pp. 472-476. (10.1002/anie.201810413)
- Verhoog, S. et al. 2018. 18F-trifluoromethylation of unmodified peptides with 5-18F-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate. Journal of the American Chemical Society 140(5), pp. 1572-1575. (10.1021/jacs.7b10227)
- Brambilla, M. and Tredwell, M. 2017. Palladium-catalyzed Suzuki-Miyaura cross-coupling of secondary α-(trifluoromethyl)benzyl tosylates. Angewandte Chemie 129(39), pp. 12143-12147. (10.1002/ange.201706631)
- Brambilla, M. and Tredwell, M. 2017. Palladium-catalyzed Suzuki-Miyaura cross-coupling of secondary α-(trifluoromethyl)benzyl tosylates. Angewandte Chemie International Edition 56(39), pp. 11981-11985. (10.1002/anie.201706631)
- Taylor, N. J. et al. 2017. Derisking the Cu-mediated 18F-fluorination of heterocyclic positron emission tomography radioligands. Journal of the American Chemical Society 139(24), pp. 8267-8276. (10.1021/jacs.7b03131)
- Wilson, T. C., McSweeney, G., Preshlock, S., Verhoog, S., Tredwell, M., Cailly, T. and V{e, . 2016. Radiosynthesis of SPECT tracers via a copper mediated123I iodination of (hetero)aryl boron reagents. Chemical Communications 52(90), pp. 13277--13280. (10.1039/c6cc07417k)
- Preshlock, S. et al. 2016. Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications. Chemical Communications 52(54), pp. 8361-8364. (10.1039/c6cc03295h)
- Preshlock, S., Tredwell, M. and Gouverneur, V. 2016. 18F-labeling of arenes and aeteroarenes for applications in Positron Emission Tomography. Chemical Reviews 116(2), pp. 719-766. (10.1021/acs.chemrev.5b00493)
- Buckingham, F. et al. 2015. Oxidative fluorination of N-arylsulfonamides. Journal of Fluorine Chemistry 180, pp. 33--39. (10.1016/j.jfluchem.2015.07.030)
- Khotavivattana, T. et al. 2015. 18F-Labeling of Aryl-SCF3, -OCF3and -OCHF2with [18F]Fluoride. Angewandte Chemie International Edition 54(34), pp. 9991-9995. (10.1002/anie.201504665)
- Verhoog, S. et al. 2015. Silver-mediated 18F-labeling of aryl-CF3 and aryl-CHF2 with 18F-fluoride. SYNLETT 27(1), pp. 25-28. (10.1055/s-0035-1560592)
- Hueting, R. et al. 2015. A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo.. Metallomics : integrated biometal science 7(5), pp. 795-804. (10.1039/c4mt00330f)
- Tredwell, M. et al. 2014. A general copper-mediated nucleophilic18F fluorination of arenes. Angewandte Chemie International Edition 53(30), pp. 7751-7755. (10.1002/anie.201404436)
- Emer, E. et al. 2014. Diversity-oriented approach to CF3CHF-, CF3CFBr-, CF3CF2-, (CF3)2CH-, and CF3(SCF3)CH-substituted arenes from 1-(diazo-2,2,2-trifluoroethyl)arenes.. Organic Letters 16(22), pp. 6004-6007. (10.1021/ol5030184)
- O'Brien, E. R. et al. 2014. Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 5(2), pp. 275-280. (10.2967/jnumed.113.127449)
- Anthony, D. C. et al. 2014. Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain.. Annals of Clinical and Translational Neurology 1(9), pp. 659-669. (10.1002/acn3.94)
- Hueting, R. et al. 2014. A comparison of the behavior of (64)Cu-acetate and (64)Cu-ATSM in vitro and in vivo.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 55(1), pp. 128-134. (10.2967/jnumed.113.119917)
- Huiban, M. et al. 2013. A broadly applicable [18F]trifluoromethylation of aryl and heteroaryl iodides for PET imaging. Nature Chemistry 5(11), pp. 941-944. (10.1038/nchem.1756)
- Benedetto, E., Tredwell, M., Hollingworth, C., Khotavivattana, T., Brown, J. M. and Gouverneur, V. 2013. Regio- and stereoretentive synthesis of branched, linear (E)- and (Z)-allyl fluorides from allyl carbonates under Ir-catalysis. Chem. Sci. 4(1), pp. 89-96. (10.1039/c2sc21789a)
- Mizuta, S. et al. 2013. Catalytic decarboxylative fluorination for the synthesis of tri- and difluoromethyl arenes.. Organic Letters 15(11), pp. 2648-2651. (10.1021/ol4009377)
- Benedetto, E., Keita, M., Tredwell, M., Hollingworth, C., Brown, J. M. and Gouverneur, V. 2012. Platinum-catalyzed substitution of allylic fluorides. Organometallics 31(4), pp. 1408-1416. (10.1021/om201029m)
- Gao, Z. et al. 2012. Metal-free oxidative fluorination of phenols with [18F]fluoride. Angewandte Chemie International Edition 51(27), pp. 6733-6737. (10.1002/anie.201201502)
- Tredwell, M. and Gouverneur, V. 2012. 18F labeling of arenes. Angewandte Chemie International Edition 51(46), pp. 11426-11437. (10.1002/anie.201204687)
- Hollingworth, C. et al. 2011. Palladium-catalyzed allylic fluorination. Angewandte Chemie International Edition 50(11), pp. 2613-2617. (10.1002/anie.201007307)
- Kersemans, V. et al. 2011. Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation.. PLoS One 6(11), article number: e25911. (10.1371/journal.pone.0025911)
- Tredwell, M. J., Gulias, M., Gaunt Bremeyer, N., Johansson, C. C. C., Collins, B. S. L. and Gaunt, M. J. 2010. Palladium(II)-catalyzed C-H bond arylation of electron-deficient arenes at room temperature. Angewandte Chemie International Edition 50(5), pp. 1076-1079. (10.1002/anie.201005990)
- Tredwell, M., Luft, J. A. R., Schuler, M., Tenza, K., Houk, K. N. and Gouverneur, V. 2008. Fluorine-directed diastereoselective iodocyclizations. Angewandte Chemie International Edition 47(2), pp. 357-360. (10.1002/anie.200703465)
- Kostov, G., Tredwell, M., Gouverneur, V. and Ameduri, B. 2007. Kinetics of radical copolymerization of [1-(fluoromethyl)vinyl]benzene with chlorotrifluoroethylene. Journal of Polymer Science Part A: Polymer Chemistry 45(17), pp. 3843-3850. (10.1002/pola.22134)
- Teare, H., Huguet, F., Tredwell, M., Thibaudeau, S., Luthra, S. and Gouveneur, V. 2007. A convergent approach for the synthesis of fluorinated sphingosine analogues. Archive for Organic Chemistry 2007(10), pp. 232-244. (10.3998/ark.5550190.0008.a14)
- Sawicki, M., Kwok, A., Tredwell, M. and Gouverneur, V. 2007. Single and double stereoselective fluorination of (E)-allylsilanes. Beilstein Journal of Organic Chemistry 3(1), pp. 34. (10.1186/1860-5397-3-34)
- Tredwell, M. and Gouverneur, V. 2006. Electrophilic fluorination of organosilanes. Org. Biomol. Chem. 4(1), pp. 26-32. (10.1039/b513399h)
- Tredwell, M., Tenza, K., Pacheco, M. C. and Gouverneur, V. 2005. Synthesis of novel enantiopure fluorinated building blocks from acyclic chiral allylsilanes.. Organic Letters 7(20), pp. 4495-4497. (10.1021/ol0518535)
Book sections
- Tredwell, M. and Gouverneur, V. 2012. 1.5 fluorine in medicinal chemistry: importance of chirality. In: Comprehensive chirality., Vol. 1. Reference module in Chemistry, Molecular Sciences and Chemical Engineering London: Elsevier, pp. 70--85., (10.1016/b978-0-08-095167-6.00106-3)
Ymchwil
Mae gan ymchwil yng Ngrŵp Tredwell ddau brif gyfeiriad, cemeg organofluorin a radiocemeg fflworin-18. Mae gennym labordai llawn offer sy'n ein galluogi i berfformio cemeg synthetig a radiocemeg yn fewnol.
Mae moleciwlau fflworinedig wedi dod o hyd i gymwysiadau eang mewn agrocemeg, fferyllol, hyd at feysydd fel gwyddor deunyddiau. Mae ein hymchwil yn ceisio datblygu dulliau newydd ar gyfer synthesis dethol ac effeithlon cyfansoddion fflworinedig cymhleth. Mae ein rhaglenni ymchwil presennol yn y maes hwn yn cynnwys
- Pontio synthesis wedi'i gataleiddio â metel o ganolfannau stereogenig C-CF3
- Fflworeiddiad electrocemegol
- Datblygu motiffau fflworineiddio newydd
Mae delweddu tomograffeg allyriadau positron (PET) yn dechneg delweddu feddyginiaethol a ddefnyddir ar gyfer diagnosis clinigol o glefyd ac i gefnogi darganfod cyffuriau. Mae'r dechneg hon yn dibynnu ar ddefnyddio radiotracwyr PET, moleciwlau sy'n cynnwys radionuclidau sy'n allyrru positron, wedi'u cynllunio i archwilio rhyngweithio biocemegol penodol. Mae fflworîn-18 yn radionuclide sy'n allyrru positron-(t1/2 = 109.7 munud) sy'n ddelfrydol ar gyfer radiolabelu moleciwlau bach. Mae llawer o'n rhaglenni cemeg synthetig yn cael eu hymyrryd yn ein hymchwil radiocemeg. Mae ein hymchwil bresennol yn y maes hwn yn cynnwys
- synthesis o 18F-perfluorinated motiffau
- Datblygiad radiotracer
- Cyfieithiad clinigol o dechnolegau radiocemegol
I gael rhagor o wybodaeth am brosiectau penodol sydd ar gael gyda Dr Matthew Tredwell darllenwch adran synthesis moleciwlaidd ein themâu prosiect ymchwil.
Bywgraffiad
- Uwch Ddarlithydd mewn Cemeg Feddyginiaethol 2023-presennol
- Uwch Gymrawd Ymchwil, Prifysgol Caerdydd, 2023-presennol
- Darlithydd mewn Cemeg Feddyginiaethol 2020-2023
- Cymrawd Ymchwil, Prifysgol Caerdydd, 2019-2023
Aelodaethau proffesiynol
Aelod o'r Gymdeithas Gemeg Frenhinol (MRSC)
Cemegydd Siartredig (CChem)
Safleoedd academaidd blaenorol
- Arweinydd Grŵp, Max-Planck-Institut für Kohlenforschung, 2015-2019
- Ymchwilydd Ôl-ddoethurol, Prifysgol Rhydychen, 2009-2015
- Ymchwilydd Ôl-ddoethurol, Prifysgol Caergrawnt, 2007-2009
- DPhil, Prifysgol Rhydychen, 2003-2007
- Prifysgol MChem Rhydychen, 1999-2003
Meysydd goruchwyliaeth
Radiocemeg
Cemeg organig
Dylunio radiotracer
Cemeg feddyginiaethol
Contact Details
TredwellM@caerdydd.ac.uk
+44 29225 12084
Y Prif Adeilad, Ystafell 0.31B, Plas y Parc, Caerdydd, CF10 3AT
+44 29225 12084
Y Prif Adeilad, Ystafell 0.31B, Plas y Parc, Caerdydd, CF10 3AT
Themâu ymchwil
Arbenigeddau
- Synthesis cemegol organig
- Delweddu biofeddygol
- Cemeg meddyginiaethol a biomolecwlaidd
- radiocemeg