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Dr Jack Underwood
Cymrawd Ymchwil Glinigol Ymddiriedolaeth Wellcome GW4-CAT, NMHRI
Trosolwyg
Rwy'n Gofrestrydd Seiciatreg Fforensig ar Lwybr Academaidd Clinigol Cymru, sydd ar hyn o bryd yn cwblhau PhD ar Gymrodoriaeth GW4-CAT Ymddiriedolaeth Wellcome. Mae fy ngwaith yn edrych ar pam mae cyflyrau iechyd meddwl a chorfforol cyd-ddigwydd yn fwy cyffredin ymhlith oedolion awtistig, gan ddefnyddio cymysgedd o dechnegau genetig epidemiolegol ac ystadegol.
Mae gen i ffocws pellach ar amrywiolion genoteip-ffenoteip yn y genyn CACNA1C, fel rhan o ddiddordeb ehangach ar fodelu pathogenesis anhwylderau niwroddatblygiadol. Fel rhan o hyn, rwy'n arwain y Bwrdd Cynghori Gwyddonol ar gyfer elusen Timothy Syndrome Alliance (TSA UK).
Cyhoeddiad
2024
- Wren, G., Flanagan, J., Underwood, J., Thompson, A., Humby, T. and Davies, W. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior
2023
- Christie, H., Hamilton-Giachritsis, C., McGuire, R., Bisson, J., Roberts, N. P., Underwood, J. and Halligan, S. 2023. Exploring the perceived impact of parental PTSD on parents and parenting behaviours – a qualitative study. Journal of Child and Family Studies 32, pp. 3378-3388. (10.1007/s10826-023-02614-z)
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60, pp. 636-643. (10.1136/jmg-2022-108862)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Levy, R., Timothy, K., Underwood, J., Hall, J., Bernstein, J. and Pasca, S. 2023. A cross-sectional study of the neuropsychiatric phenotype of CACNA1C-related disorder. Pediatric Neurology 138, pp. 101-106. (10.1016/j.pediatrneurol.2022.10.013)
2022
- Underwood, J., DelPozo-Banos, M., Frizzati, A., Rai, D., John, A. and Hall, J. 2022. Neurological and psychiatric disorders among autistic adults: a population healthcare record study. Psychological Medicine (10.1017/S0033291722002884)
- Underwood, J. F. G., DelPozo-Banos, M., Frizzati, A., John, A. and Hall, J. 2022. Evidence of increasing recorded diagnosis of autism spectrum disorders in Wales, UK – an e-cohort study. Autism 26(6), pp. 1499-1508. (10.1177/13623613211059674)
- Brcic, L., Wren, G., Underwood, J., Kirov, G. and Davies, W. 2022. Comorbid medical issues in X-linked ichthyosis [Letter]. JID Innovations 2(3), article number: 100109. (10.1016/j.xjidi.2022.100109)
2021
- Hoskins, M. D. et al. 2021. Pharmacological therapy for post-traumatic stress disorder: a systematic review and meta-analysis of monotherapy, augmentation and head-to-head approaches. European Journal of Psychotraumatology 12(1), article number: 1802920. (10.1080/20008198.2020.1802920)
- Hoskins, M. D. et al. 2021. Pharmacological-assisted psychotherapy for post-traumatic stress disorder: a systematic review and meta-analysis. European Journal of Psychotraumatology 12(1), article number: 1853379. (10.1080/20008198.2020.1853379)
2020
- Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57(10), pp. 692-698. (10.1136/jmedgenet-2019-106676)
- Gubb, S., Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29(17), pp. 2872-2881. (10.1093/hmg/ddaa174)
2019
- Underwood, J., Kendall, K., Berrett, J., Lewis, C., Anney, R., Van den Bree, M. and Hall, J. 2019. Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort. British Journal of Psychiatry 215(5), pp. 647-653. (10.1192/bjp.2019.30)
- Underwood, J., Kendall, K., Berrett, J., Anney, R., Bree, M. V. D. and Hall, J. 2019. SA20COPY Number variants and polygenic risk scores in adults with autism spectrum disorder (ASD): results from the NCMH adult ASD cohort. European Neuropsychopharmacology 29(S4), pp. S1198-S1199. (10.1016/j.euroneuro.2018.08.242)
2017
- Black, L. F. and Underwood, J. F. G. 2017. P.3.b.045 - Psychosis in Wilson’s disease: an unusual presentation of bipolar affective disorder. Presented at: 30th ECNP Congress 2017, Paris, France, 2-5 September 2017, Vol. 27. Vol. Supple. Elsevier pp. S915., (10.1016/S0924-977X(17)31627-9)
Articles
- Wren, G., Flanagan, J., Underwood, J., Thompson, A., Humby, T. and Davies, W. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior
- Christie, H., Hamilton-Giachritsis, C., McGuire, R., Bisson, J., Roberts, N. P., Underwood, J. and Halligan, S. 2023. Exploring the perceived impact of parental PTSD on parents and parenting behaviours – a qualitative study. Journal of Child and Family Studies 32, pp. 3378-3388. (10.1007/s10826-023-02614-z)
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60, pp. 636-643. (10.1136/jmg-2022-108862)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Levy, R., Timothy, K., Underwood, J., Hall, J., Bernstein, J. and Pasca, S. 2023. A cross-sectional study of the neuropsychiatric phenotype of CACNA1C-related disorder. Pediatric Neurology 138, pp. 101-106. (10.1016/j.pediatrneurol.2022.10.013)
- Underwood, J., DelPozo-Banos, M., Frizzati, A., Rai, D., John, A. and Hall, J. 2022. Neurological and psychiatric disorders among autistic adults: a population healthcare record study. Psychological Medicine (10.1017/S0033291722002884)
- Underwood, J. F. G., DelPozo-Banos, M., Frizzati, A., John, A. and Hall, J. 2022. Evidence of increasing recorded diagnosis of autism spectrum disorders in Wales, UK – an e-cohort study. Autism 26(6), pp. 1499-1508. (10.1177/13623613211059674)
- Brcic, L., Wren, G., Underwood, J., Kirov, G. and Davies, W. 2022. Comorbid medical issues in X-linked ichthyosis [Letter]. JID Innovations 2(3), article number: 100109. (10.1016/j.xjidi.2022.100109)
- Hoskins, M. D. et al. 2021. Pharmacological therapy for post-traumatic stress disorder: a systematic review and meta-analysis of monotherapy, augmentation and head-to-head approaches. European Journal of Psychotraumatology 12(1), article number: 1802920. (10.1080/20008198.2020.1802920)
- Hoskins, M. D. et al. 2021. Pharmacological-assisted psychotherapy for post-traumatic stress disorder: a systematic review and meta-analysis. European Journal of Psychotraumatology 12(1), article number: 1853379. (10.1080/20008198.2020.1853379)
- Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57(10), pp. 692-698. (10.1136/jmedgenet-2019-106676)
- Gubb, S., Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29(17), pp. 2872-2881. (10.1093/hmg/ddaa174)
- Underwood, J., Kendall, K., Berrett, J., Lewis, C., Anney, R., Van den Bree, M. and Hall, J. 2019. Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort. British Journal of Psychiatry 215(5), pp. 647-653. (10.1192/bjp.2019.30)
- Underwood, J., Kendall, K., Berrett, J., Anney, R., Bree, M. V. D. and Hall, J. 2019. SA20COPY Number variants and polygenic risk scores in adults with autism spectrum disorder (ASD): results from the NCMH adult ASD cohort. European Neuropsychopharmacology 29(S4), pp. S1198-S1199. (10.1016/j.euroneuro.2018.08.242)
Conferences
- Black, L. F. and Underwood, J. F. G. 2017. P.3.b.045 - Psychosis in Wilson’s disease: an unusual presentation of bipolar affective disorder. Presented at: 30th ECNP Congress 2017, Paris, France, 2-5 September 2017, Vol. 27. Vol. Supple. Elsevier pp. S915., (10.1016/S0924-977X(17)31627-9)
Ymchwil
Mae awtistiaeth yn gyflwr niwroddatblygiadol gydol oes sy'n effeithio ar ~1% o bobl. Mae problemau iechyd meddwl yn fwy cyffredin ymhlith pobl awtistig, ond nid ydym yn deall pam. Mae fy PhD yn edrych ar hyn, a pha effeithiau y mae geneteg neu ffordd o fyw yn eu cael ar iechyd meddwl oedolion awtistig. Rwy'n archwilio effeithiau risg polygenig feintiol bresennol ar gyfer anhwylderau iechyd meddwl (PGS) yn y boblogaeth awtistig, ochr yn ochr â chymdeithasau o fewn ysbytai ac ymarfer cyffredinol yn cofnodi data ar anawsterau iechyd meddwl dilynol. Er mwyn cyflawni hyn, rwyf wedi nodi a chydgynhyrchu asesiadau mewn carfan o oedolion awtistig o Gronfa Ddata'r Ganolfan Genedlaethol ar gyfer Iechyd Meddwl (NCMH), yn ogystal â phobl awtistig o fewn set ddata fawr o gofnodion gofal iechyd dienw (SAIL) a sampl poblogaeth hydredol (ALSPAC).
Ar gyfer y prosiectau hyn rwy'n cael fy ngoruchwylio gan yr Athro Jeremy Hall (Caerdydd), Dr Ric Anney (Caerdydd), a'r Athro Dheeraj Rai (Prifysgol Bryste, Gwyddorau Iechyd y Boblogaeth).
Mae gen i edefyn pellach o ddiddordeb ymchwil ym mherthynas ffenoteip-genoteip CACNA1C amrywiadau, gyda'r nod o sefydlu nodweddion ffenoteipig sy'n gysylltiedig ag amrywiadau genynnau ar draws loci yn y genyn hwn. Mae fy ffocws penodol ar anhwylderau niwroddatblygiadol o fewn y cyd-destun hwn, a modelu sut mae newidiadau yn y genyn hwn yn arwain at y nodweddion hyn. I archwilio hyn, rwyf wedi llunio cyfres ryngwladol o achosion o unigolion gyda CACNA1C a'u teuluoedd, gyda phenoteipio dwfn a llinellau celloedd (lle bo ar gael). Rwy'n arwain y Bwrdd Cynghori Gwyddonol ar gyfer elusen Timothy Syndrome League, ac wedi trefnu a chynnal cynadleddau a digwyddiadau ar gyfer yr elusen. Dyfarnwyd cyllid grant i ni ar gyfer ffilm ymgysylltu â'r cyhoedd yn 2021, cyllid pellach yn 2022 ar gyfer cyfieithu rhyngwladol o gynadleddau, ac ennill Partneriaeth Ymchwil Gorau Gwobrau Gene People 2022.
Addysgu
Rwy'n addysgu ar sawl cwrs yng Nghaerdydd a Phrifysgol Abertawe, ar lefel israddedig ac ôl-raddedig.
Ar gyfer y cwrs MBBCh Meddygaeth, rwy'n darlithio ar niwroanatomeg ac yn darparu addysgu mewn grwpiau bach ar anhwylderau personoliaeth a sgiliau cyfathrebu. Rwy'n arholwr ISCE seiciatreg ffurfiannol a chrynodol. Rwyf wedi goruchwylio prosiectau rhyng-gyfrifo myfyrwyr ar y cwrs BSc Seicoleg mewn Meddygaeth. Rwy'n goruchwylio prosiectau SSC, gan gynnwys gwaith labordy gwlyb a sych.
Rwyf wedi darparu data a goruchwyliaeth ar gyfer astudiaethau achos myfyrwyr ar yr MSc mewn Biowybodeg Gymhwysol a Genomeg. Rwyf hefyd wedi goruchwylio prosiectau traethawd hir ar yr MSc mewn Seiciatreg, a'r Doethuriaeth mewn Seicoleg Glinigol.
Bywgraffiad
Rwy'n Gofrestrydd Seiciatreg Fforensig ar Lwybr Academaidd Clinigol Cymru, yn ddiweddar yn ôl i hyfforddiant clinigol ar lefel ST4/5 ac yn ysgrifennu PhD ar Gymrodoriaeth GW4-CAT Ymddiriedolaeth Wellcome. Cynhaliais Hyfforddiant Seiciatreg Craidd a'r Rhaglen Sylfaen yn Ne Cymru, ar ôl graddio o Feddygaeth (BMBS) yng Ngholeg Meddygaeth a Deintyddiaeth Penrhyn. Rwyf wedi bod yn aelod o Goleg Brenhinol y Seiciatryddion ers 2018.
Anrhydeddau a dyfarniadau
2022 – Gwobrau Gene People - Partneriaeth Ymchwil Gorau - Enillydd, gyda Timothy Syndrome Alliance
2019 – Cymrodoriaeth Hyfforddiant Academaidd Clinigol Ymddiriedolaeth Wellcome GW4-CAT
2018 – Gwobr Primer Clinigol ISSF Ymddiriedolaeth Wellcome
2018 – RCPsych International Congress Travel Bursary
2018 – Grant Teithio Cyngres Cymdeithas Seiciatrig Ewrop
2016 – Cynllun Mentora Academaidd Clinigol Canolfan MRC Caerdydd
Aelodaethau proffesiynol
Member of the Royal College of Psychiatrists (MRCPsych)
Registered with the General Medical Council (7414226)
Pwyllgorau ac adolygu
Rwyf wedi adolygu nifer o gyhoeddiadau ar gyfer amrywiaeth o gyfnodolion, gan gynnwys: JAMA Psychiatry, The British Journal of Psychiatry (BJPsych), BJPsych Bulletin, BJPsych Open, Ymchwil mewn Anhwylderau Datblygiadol, Seiciatreg Fiolegol, Datblygiadau mewn Awtistiaeth, Ymchwil mewn Anhwylderau Sbectrwm Awtistiaeth.
Trwy fenter Niwrowyddoniaeth Wellcome Gatsby roeddwn yn ymwneud â hyrwyddo Niwrowyddoniaeth ar gyfer Coleg Brenhinol y Seiciatryddion, i ddechrau fel Golygydd Hyfforddeion Niwrowyddoniaeth ar gyfer TrOn ac yn ddiweddarach Pencampwr Niwrowyddoniaeth RCPsych dros Gymru.
Mae gennyf brofiad pellach o gomisiynu a llywodraethu clinigol drwy nifer o bwyllgorau, gan gynnwys Grŵp Cynghori Clinigol Awtistiaeth a Niwroamrywiaeth Llywodraeth Cymru.