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Dr Jack Underwood
(e/fe)
Timau a rolau for Jack Underwood
Cymrawd Trac Academaidd Clinigol Cymru (WCAT)
Myfyriwr ymchwil
Trosolwyg
Rwy'n Gofrestrydd Seiciatreg Fforensig ar Drac Academaidd Clinigol Cymru, ar ôl dychwelyd i hyfforddiant clinigol yn ddiweddar ar ôl cwblhau PhD ar Gymrodoriaeth Ddoethurol Glinigol GW4-CAT Ymddiriedolaeth Wellcome. Mae fy ngwaith PhD yn edrych ar pam mae cyflyrau iechyd meddwl a chorfforol sy'n cyd-ddigwydd yn fwy cyffredin mewn oedolion awtistig, gan ddefnyddio cymysgedd o dechnegau genetig epidemiolegol ac ystadegol.
Mae gennyf ffocws pellach ar amrywiadau genoteip-ffenoteip yn y genyn CACNA1C, fel rhan o ddiddordeb ehangach ar fodelu pathogenesis anhwylderau niwroddatblygiadol. Fel rhan o hyn, rwy'n cadeirio'r Bwrdd Cynghori Gwyddonol ar gyfer elusen Cynghrair Syndrom Timothy (TSA UK), ac yn cyd-arwain ar ddyfarniad grant CZI Rare As One y TSA.
Cyhoeddiad
2025
- Dardani, C. et al. 2025. Psychotic experiences and disorders in adolescents and young adults with borderline intellectual functioning and intellectual disabilities: evidence from a population-based birth cohort in the United Kingdom. Psychological Medicine 55, article number: e23. (10.1017/S0033291724003556)
- Tackley, G., Unwin, K., Underwood, J. and Jones, C. 2025. The experience of itch in autistic adults: An online survey. Autism in Adulthood
2024
- Hunt, M., Underwood, J., Hubbard, L. and Hall, J. 2024. Risk of physical health comorbidities in autistic adults: a clinical nested cross-sectional study. BJPsych Open 10(6), article number: e182. (10.1192/bjo.2024.777)
- Wren, G., Flanagan, J., Underwood, J., Thompson, A., Humby, T. and Davies, W. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior 23(3), article number: e12893. (10.1111/gbb.12893)
2023
- Christie, H., Hamilton-Giachritsis, C., McGuire, R., Bisson, J., Roberts, N. P., Underwood, J. and Halligan, S. 2023. Exploring the perceived impact of parental PTSD on parents and parenting behaviours – a qualitative study. Journal of Child and Family Studies 32, pp. 3378-3388. (10.1007/s10826-023-02614-z)
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60, pp. 636-643. (10.1136/jmg-2022-108862)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Levy, R., Timothy, K., Underwood, J., Hall, J., Bernstein, J. and Pasca, S. 2023. A cross-sectional study of the neuropsychiatric phenotype of CACNA1C-related disorder. Pediatric Neurology 138, pp. 101-106. (10.1016/j.pediatrneurol.2022.10.013)
2022
- Underwood, J., DelPozo-Banos, M., Frizzati, A., Rai, D., John, A. and Hall, J. 2022. Neurological and psychiatric disorders among autistic adults: a population healthcare record study. Psychological Medicine (10.1017/S0033291722002884)
- Underwood, J. F. G., DelPozo-Banos, M., Frizzati, A., John, A. and Hall, J. 2022. Evidence of increasing recorded diagnosis of autism spectrum disorders in Wales, UK – an e-cohort study. Autism 26(6), pp. 1499-1508. (10.1177/13623613211059674)
- Brcic, L., Wren, G., Underwood, J., Kirov, G. and Davies, W. 2022. Comorbid medical issues in X-linked ichthyosis [Letter]. JID Innovations 2(3), article number: 100109. (10.1016/j.xjidi.2022.100109)
2021
- Hoskins, M. D. et al. 2021. Pharmacological-assisted psychotherapy for post-traumatic stress disorder: a systematic review and meta-analysis. European Journal of Psychotraumatology 12(1), article number: 1853379. (10.1080/20008198.2020.1853379)
- Hoskins, M. D. et al. 2021. Pharmacological therapy for post-traumatic stress disorder: a systematic review and meta-analysis of monotherapy, augmentation and head-to-head approaches. European Journal of Psychotraumatology 12(1), article number: 1802920. (10.1080/20008198.2020.1802920)
2020
- Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57(10), pp. 692-698. (10.1136/jmedgenet-2019-106676)
- Gubb, S., Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29(17), pp. 2872-2881. (10.1093/hmg/ddaa174)
2019
- Underwood, J., Kendall, K., Berrett, J., Lewis, C., Anney, R., Van den Bree, M. and Hall, J. 2019. Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort. British Journal of Psychiatry 215(5), pp. 647-653. (10.1192/bjp.2019.30)
- Underwood, J., Kendall, K., Berrett, J., Anney, R., Bree, M. V. D. and Hall, J. 2019. SA20COPY Number variants and polygenic risk scores in adults with autism spectrum disorder (ASD): results from the NCMH adult ASD cohort. European Neuropsychopharmacology 29(S4), pp. S1198-S1199. (10.1016/j.euroneuro.2018.08.242)
2017
- Black, L. F. and Underwood, J. F. G. 2017. P.3.b.045 - Psychosis in Wilson’s disease: an unusual presentation of bipolar affective disorder. Presented at: 30th ECNP Congress 2017, Paris, France, 2-5 September 2017, Vol. 27. Vol. Supple. Elsevier pp. S915., (10.1016/S0924-977X(17)31627-9)
Articles
- Dardani, C. et al. 2025. Psychotic experiences and disorders in adolescents and young adults with borderline intellectual functioning and intellectual disabilities: evidence from a population-based birth cohort in the United Kingdom. Psychological Medicine 55, article number: e23. (10.1017/S0033291724003556)
- Tackley, G., Unwin, K., Underwood, J. and Jones, C. 2025. The experience of itch in autistic adults: An online survey. Autism in Adulthood
- Hunt, M., Underwood, J., Hubbard, L. and Hall, J. 2024. Risk of physical health comorbidities in autistic adults: a clinical nested cross-sectional study. BJPsych Open 10(6), article number: e182. (10.1192/bjo.2024.777)
- Wren, G., Flanagan, J., Underwood, J., Thompson, A., Humby, T. and Davies, W. 2024. Memory, mood and associated neuroanatomy in individuals with steroid sulfatase deficiency (X-linked ichthyosis). Genes, Brain and Behavior 23(3), article number: e12893. (10.1111/gbb.12893)
- Christie, H., Hamilton-Giachritsis, C., McGuire, R., Bisson, J., Roberts, N. P., Underwood, J. and Halligan, S. 2023. Exploring the perceived impact of parental PTSD on parents and parenting behaviours – a qualitative study. Journal of Child and Family Studies 32, pp. 3378-3388. (10.1007/s10826-023-02614-z)
- Wren, G. et al. 2023. Characterising heart rhythm abnormalities associated with Xp22.31 deletion. Journal of Medical Genetics 60, pp. 636-643. (10.1136/jmg-2022-108862)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Levy, R., Timothy, K., Underwood, J., Hall, J., Bernstein, J. and Pasca, S. 2023. A cross-sectional study of the neuropsychiatric phenotype of CACNA1C-related disorder. Pediatric Neurology 138, pp. 101-106. (10.1016/j.pediatrneurol.2022.10.013)
- Underwood, J., DelPozo-Banos, M., Frizzati, A., Rai, D., John, A. and Hall, J. 2022. Neurological and psychiatric disorders among autistic adults: a population healthcare record study. Psychological Medicine (10.1017/S0033291722002884)
- Underwood, J. F. G., DelPozo-Banos, M., Frizzati, A., John, A. and Hall, J. 2022. Evidence of increasing recorded diagnosis of autism spectrum disorders in Wales, UK – an e-cohort study. Autism 26(6), pp. 1499-1508. (10.1177/13623613211059674)
- Brcic, L., Wren, G., Underwood, J., Kirov, G. and Davies, W. 2022. Comorbid medical issues in X-linked ichthyosis [Letter]. JID Innovations 2(3), article number: 100109. (10.1016/j.xjidi.2022.100109)
- Hoskins, M. D. et al. 2021. Pharmacological-assisted psychotherapy for post-traumatic stress disorder: a systematic review and meta-analysis. European Journal of Psychotraumatology 12(1), article number: 1853379. (10.1080/20008198.2020.1853379)
- Hoskins, M. D. et al. 2021. Pharmacological therapy for post-traumatic stress disorder: a systematic review and meta-analysis of monotherapy, augmentation and head-to-head approaches. European Journal of Psychotraumatology 12(1), article number: 1802920. (10.1080/20008198.2020.1802920)
- Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57(10), pp. 692-698. (10.1136/jmedgenet-2019-106676)
- Gubb, S., Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29(17), pp. 2872-2881. (10.1093/hmg/ddaa174)
- Underwood, J., Kendall, K., Berrett, J., Lewis, C., Anney, R., Van den Bree, M. and Hall, J. 2019. Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort. British Journal of Psychiatry 215(5), pp. 647-653. (10.1192/bjp.2019.30)
- Underwood, J., Kendall, K., Berrett, J., Anney, R., Bree, M. V. D. and Hall, J. 2019. SA20COPY Number variants and polygenic risk scores in adults with autism spectrum disorder (ASD): results from the NCMH adult ASD cohort. European Neuropsychopharmacology 29(S4), pp. S1198-S1199. (10.1016/j.euroneuro.2018.08.242)
Conferences
- Black, L. F. and Underwood, J. F. G. 2017. P.3.b.045 - Psychosis in Wilson’s disease: an unusual presentation of bipolar affective disorder. Presented at: 30th ECNP Congress 2017, Paris, France, 2-5 September 2017, Vol. 27. Vol. Supple. Elsevier pp. S915., (10.1016/S0924-977X(17)31627-9)
Ymchwil
Mae awtistiaeth yn gyflwr niwroddatblygiadol gydol oes sy'n effeithio ar ~ 1% o bobl. Mae problemau iechyd meddwl yn fwy cyffredin mewn pobl awtistig, ond nid ydym yn deall pam. Mae fy PhD yn edrych ar hyn, a pha effeithiau mae geneteg neu ffordd o fyw yn eu cael ar iechyd meddwl oedolion awtistig. Rwy'n archwilio effeithiau risg polygenig meintiol presennol ar gyfer anhwylderau iechyd meddwl (PGS) yn y boblogaeth awtistig, ochr yn ochr â chymdeithasau o fewn data cofnodion ysbytai a phractis cyffredinol ar anawsterau iechyd meddwl dilynol. I ymgymryd â hyn, rwyf wedi nodi a chyd-gynhyrchu asesiadau mewn carfan o oedolion awtistig o Gronfa Ddata y Ganolfan Genedlaethol ar gyfer Iechyd Meddwl (NCMH), yn ogystal â phobl awtistig o fewn set ddata fawr o gofnodion gofal iechyd dienw (SAIL) a sampl poblogaeth hydredol (ALSPAC).
Ar gyfer y prosiectau hyn, cefais fy ngoruchwylio gan yr Athro Jeremy Hall (Caerdydd), Dr Ric Anney (Caerdydd), a'r Athro Dheeraj Rai (Prifysgol Bryste, Gwyddorau Iechyd y Boblogaeth).
Mae gen i ddiddordeb ymchwil pellach yn y berthynas ffenoteip-genoteip amrywiadau CACNA1C , gyda'r nod o sefydlu nodweddion ffenoteipig sy'n gysylltiedig ag amrywiadau genynnau ar draws loci yn y genyn hwn. Mae fy ffocws arbennig ar anhwylderau niwroddatblygiadol yn y cyd-destun hwn, a modelu sut mae newidiadau yn y genyn hwn yn arwain at y nodweddion hyn. I archwilio hyn rwyf wedi llunio cyfres o achosion rhyngwladol o unigolion gyda CACNA1C a'u teuluoedd, gyda ffenoteipio dwfn a llinellau celloedd (lle mae ar gael). Rwy'n arwain y Bwrdd Cynghori Gwyddonol ar gyfer elusen Timothy Syndrome Alliance, ac wedi trefnu a chynnal cynadleddau a digwyddiadau i'r elusen. Dyfarnwyd cyllid grant i ni ar gyfer ffilm ymgysylltu â'r cyhoedd yn 2021, cyllid pellach yn 2022 ar gyfer cyfieithu cynadleddau rhyngwladol, ac enillwyd Partneriaeth Ymchwil Orau Gwobrau Gene People 2022. Ym mis Hydref 2024 cawsom ni (Cynghrair Syndrom Timothy) dderbyn grant cylch 3 Menter Chan Zuckerberg Rare As One ($ 800,000), gan ariannu graddfa'r elusen, i feithrin rhwydweithiau ymchwil a datblygu platfform ymchwil CACNA1C. Yn 2025 dyfarnwyd grant Ymchwilydd Gyrfa Gynnar Sefydliad Hodge i ymgymryd â dadansoddiadau genoteip-ffenoteip o'r genyn CACNA1C ymhellach. Yng Ngwobrau Ffilm Elusennol Smiley 2025, enillodd ein ffilm ymgysylltu â'r cyhoedd ar y cyd Connections Wobr Barn y Bobl (Longform, <£500,000). Am fy ngwaith PPIE ar CACNA1C a gyda TSA cefais ganmoliaeth uchel yng ngwobr PPIE Ymchwilydd Cynnar Clefydau Prin y DU.
Addysgu
Rwy'n addysgu ar sawl cwrs yng Nghaerdydd a Phrifysgol Abertawe, ar lefel israddedig ac ôl-raddedig.
Ar gyfer y cwrs MBBCh Meddygaeth, rwy'n darlithio ar niwroanatomeg ac yn darparu addysgu mewn grwpiau bach ar anhwylderau personoliaeth a sgiliau cyfathrebu. Rwy'n arholwr ISCE seiciatreg ffurfiannol a chrynodol. Rwyf wedi goruchwylio prosiectau rhyng-gyfrifo myfyrwyr ar y cwrs BSc Seicoleg mewn Meddygaeth. Rwy'n goruchwylio prosiectau SSC, sy'n cynnwys lleoliadau clinigol, yn ogystal â phrosiectau ymchwil gwlyb a sych.
Rwyf wedi darparu data a goruchwyliaeth ar gyfer astudiaethau achos myfyrwyr ar yr MSc mewn Biowybodeg Gymhwysol a Genomeg. Rwyf hefyd wedi goruchwylio prosiectau traethawd hir ar yr MSc mewn Seiciatreg, a'r Doethuriaeth mewn Seicoleg Glinigol.
Bywgraffiad
Rwy'n Gofrestrydd Seiciatreg Fforensig ar Drac Academaidd Clinigol Cymru, yn ddiweddar yn ôl i hyfforddiant clinigol ar lefel ST5 ac ar ôl cwblhau PhD (viva pasio hyd nes y bydd mân gywiriadau) ar Gymrodoriaeth Ddoethurol Glinigol GW4-CAT Ymddiriedolaeth Wellcome. Ymgymerais â Hyfforddiant Seiciatreg Craidd a'r Rhaglen Sylfaen yn Ne Cymru, ar ôl graddio o Feddygaeth (BMBS) yng Ngholeg Meddygaeth a Deintyddiaeth y Penrhyn. Rwyf wedi bod yn aelod o Goleg Brenhinol y Seiciatryddion ers 2018.
Anrhydeddau a dyfarniadau
2025 - Gwobrau Ffilm Elusennol Smiley, Enillydd Gwobr Barn y Bobl - ffilm ymgysylltu â'r cyhoedd ar y cyd "Connections"
2025 - Gwobr PPIE Ymchwilydd Cynnar Ymchwil Clefydau Prin y DU - Canmoliaeth Uchel
2025 - Grant Ymchwil Gyrfa Ddechrau Sefydliad Hodge (£18,490)
2024 - Menter Chan Zuckerberg Prin Fel Un Grant - fel Cadeirydd Bwrdd Cynghori Gwyddonol TSA ($ 800,000)
2022 – Gwobrau Gene People - Partneriaeth Ymchwil Orau - Enillydd, gyda Chynghrair Syndrom Timothy
2021 - Cronfa Ymgysylltu â'r Cyhoedd Arloesedd i Bawb Prifysgol Caerdydd (IfA): Taith Ymchwil Clefydau Prin (£6,350)
2019 – Cymrodoriaeth Hyfforddiant Academaidd Clinigol GW4-CAT Ymddiriedolaeth Wellcome (£280,000)
2018 – Gwobr Primer Clinigol ISSF Ymddiriedolaeth Wellcome (£29,984)
2018 – Bwrsariaeth Teithio Cyngres Ryngwladol RCPsych (£450)
2018 – Grant Teithio Cyngres Cymdeithas Seiciatrig Ewrop (350 Ewro)
2016 – Cynllun Mentora Academaidd Clinigol Canolfan MRC Caerdydd
Aelodaethau proffesiynol
Member of the Royal College of Psychiatrists (MRCPsych)
Registered with the General Medical Council (7414226)
Pwyllgorau ac adolygu
Rwyf wedi adolygu sawl cyhoeddiad gan gymheiriaid ar gyfer amrywiaeth o gyfnodolion, gan gynnwys: JAMA Psychiatry, The British Journal of Psychiatry (BJPsych), BJPsych Bulletin, BJPsych Open, Research in Developmental Disorders, Biological Psychiatry, Journal of Intellectual Disability Research, Autism, Advances in Autism, Research in Autism Spectrum Disorders.
Drwy fenter Niwrowyddoniaeth Wellcome Gatsby, roeddwn yn ymwneud â hyrwyddo Niwrowyddoniaeth ar gyfer Coleg Brenhinol y Seiciatryddion, i ddechrau fel Golygydd Hyfforddai Niwrowyddoniaeth ar gyfer TrOn ac yn ddiweddarach Hyrwyddwr Niwrowyddoniaeth RCPsych yng Nghymru.
Mae gen i brofiad pellach o gomisiynu a llywodraethu clinigol drwy nifer o bwyllgorau, gan gynnwys Grŵp Cynghori Clinigol Awtistiaeth a Niwroamrywiaeth Llywodraeth Cymru.
Contact Details
Themâu ymchwil
Arbenigeddau
- Geneteg Seiciatrig
