![Marianne van den Bree](https://profiles-cardiff.imgix.net/attachments/2632?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Marianne van den Bree
(hi/ei)
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Marianne van den Bree
Athro, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
Trosolwyg
Rwy'n Athro Meddygaeth Seicolegol yn yr Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol, Canolfan MRC ar gyfer Geneteg a Genomeg Niwroseiciatrig a'r Sefydliad Ymchwil Niwrowyddoniaeth ac Iechyd Meddwl ym Mhrifysgol Caerdydd.
Mae fy ymchwil yn canolbwyntio ar nodweddu'r ffactorau genetig ac amgylcheddol sy'n chwarae rhan yn natblygiad anhwylderau iechyd meddwl. Mae hyn yn cynnwys deall y perthnasoedd datblygiadol cymhleth ar draws y rhychwant oes rhwng anhwylderau iechyd meddwl a chyflyrau eraill sy'n gysylltiedig ag iechyd.
Mae fy nghefndir mewn seicoleg, geneteg ddynol ac epidemioleg/methodoleg.
Mae gen i ddiddordeb yn yr amlygiadau datblygiadol, ymddygiadol, gwybyddol a seiciatrig ac iechyd corfforol eang y gall pobl ag amrywiadau genomig prin eu profi, gan gynnwys microdeletions cromosomaidd a dyblygiadau a elwir yn Amrywiadau Rhifau Copi (CNVs).
Mae gen i brofiad helaeth o chwarae rolau blaenllaw mewn consortia rhyngwladol sy'n astudio CNV ac iechyd meddwl.
Nod allweddol hefyd yw cyfathrebu canfyddiadau ymchwil iechyd meddwl yn eang ac ymdrechu i gael budd cymdeithasol.
Cyhoeddiad
2025
- Rammos, A. et al. 2025. Copy number variants and their implications for developmental and behavioural problems in cleft lip and/or palate. Human Molecular Genetics, article number: ddaf115. (10.1093/hmg/ddaf115)
- Katzourou, I. et al. 2025. Contributions of common and rare genetic variation to different measures of mood and anxiety disorder in UK Biobank. BJPsych Open 11(3), article number: e97. (10.1192/bjo.2025.43)
- Silva, A. et al. 2025. Penetrance of neurodevelopmental copy number variants is associated with variations in cortical morphology. Biological Psychiatry (10.1016/j.bpsc.2025.05.010)
- Lee, I. et al. 2025. Inequalities of the waiting time for education health and care plan provision for pupils with intellectual developmental disabilities: a brief report. Journal of Intellectual Disability Research (10.1111/jir.13239)
- Gur, R. C. et al. 2025. Neurocognitive profiles of 22q11.2 and 16p11.2 deletions and duplications. Molecular Psychiatry 30, pp. 379-387. (10.1038/s41380-024-02661-y)
- Ali, N. M. et al. 2025. Comparison of autism domains across thirty rare variant genotypes. EBioMedicine 112, article number: 105521. (10.1016/j.ebiom.2024.105521)
2024
- Lee, I. O. et al. 2024. The inequity of education, health and care plan provision for children and young people with intellectual and developmental disabilities. Journal of Intellectual Disability Research 68(10), pp. 1167-1183. (10.1111/jir.13139)
- Benger, L., LINC Consortium, ., Holmans, P., Owen, M., Mon-Williams, M., Katzourou, I. and Van den Bree, M. 2024. Adverse childhood experiences and multimorbidity of internalising and cardiometabolic conditions in an older-age population. Presented at: International Population Data Linkage Conference, Chicago, USA, 15-18 September 2025Conference Proceedings for International Population Data Linkage Conference, Vol. 9. Vol. 5. Swansea University pp. 133., (10.23889/ijpds.v9i5.2617)
- Hall, J. H. et al. 2024. Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs). Translational Psychiatry 14(1), article number: 259. (10.1038/s41398-024-02975-z)
- Kopal, J. et al. 2024. Using rare genetic mutations to revisit structural brain asymmetry. Nature Communications 15(1), article number: 2639. (10.1038/s41467-024-46784-w)
- Butter, C. E., Goldie, C. L., Hall, J. H., Leadbitter, K., Burkitt, E. M., van den Bree, M. B. and Green, J. M. 2024. Experiences and concerns of parents of children with a 16p11.2 deletion or duplication diagnosis: a reflexive thematic analysis. BMC Psychology 12, article number: 137. (10.1186/s40359-024-01609-9)
- Doherty, J. L. et al. 2024. Atypical cortical networks in children at high-genetic risk of psychiatric and eurodevelopmental disorders. Neuropsychopharmacology 49, pp. 368-376. (10.1038/s41386-023-01628-x)
- Boen, R. et al. 2024. Beyond the global brain differences: Intra-individual variability differences in 1q21.1 distal and 15q11.2 BP1-BP2 deletion carriers. Biological Psychiatry 95(2), pp. 147-160. (10.1016/j.biopsych.2023.08.018)
- Ge, R. et al. 2024. Source‐based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome. Human Brain Mapping 45(1), article number: e26553. (10.1002/hbm.26553)
2023
- Raven, E. et al. 2023. In vivo evidence of microstructural hypo-connectivity of brain white matter in 22q11.2 deletion syndrome. Molecular Psychiatry 28, pp. 4342-4352. (10.1038/s41380-023-02178-w)
- Kumar, K. et al. 2023. Subcortical brain alterations in carriers of genomic copy number variants. The American Journal of Psychiatry 180(9), pp. 685-698. (10.1176/appi.ajp.20220304)
- Zhao, Y. et al. 2023. Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS. npj Genomic Medicine 8(1), article number: 17. (10.1038/s41525-023-00363-y)
- Kopal, J. et al. 2023. Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence. Nature Human Behaviour 7, pp. 1001-1007. (10.1038/s41562-023-01541-9)
- Chawner, S. J. et al. 2023. Neurodevelopmental dimensional assessment of young children at high genomic risk of neuropsychiatric conditions. JCPP Advances 3(2), article number: e12162. (10.1002/jcv2.12162)
- Niarchou, M. et al. 2023. Psychopathology in mothers of children with pathogenic copy number variants. Journal of Medical Genetics 60, pp. 706-711. (10.1136/jmg-2022-108752)
- Rogdaki, M. et al. 2023. Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study. Molecular Psychiatry 28, pp. 1995-2006. (10.1038/s41380-021-01108-y)
- Adams, R. L. et al. 2023. Psychopathology in adults with copy number variants. Psychological Medicine 53(7), pp. 3142-3149. (10.1017/S0033291721005201)
- Lin, J. et al. 2023. Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia. Molecular Psychiatry 28, pp. 2071-2080. (10.1038/s41380-023-02009-y)
- Donnelly, N. et al. 2023. Identifying the neurodevelopmental and psychiatric signatures of genomic disorders associated with intellectual disability: a machine learning approach. Molecular Autism 14(1), article number: 19. (10.1186/s13229-023-00549-2)
- Moreau, C. A. et al. 2023. Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions. Brain 146(4), pp. 1686-1696. (10.1093/brain/awac315)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Moreau, C. A. et al. 2023. Genetic heterogeneity shapes brain connectivity in psychiatry. Biological Psychiatry 93(1), pp. 45-58. (10.1016/j.biopsych.2022.08.024)
- Wolstencroft, J. et al. 2023. Mental health impact of autism on families of children with intellectual and developmental disabilities of genetic origin. JCPP Advances, article number: e12128. (10.1002/jcv2.12128)
- Chawner, S. J. R. A., Evans, A., IMAGINE-ID consortium, ., Williams, N., Owen, M. J., Hall, J. and van den Bree, M. B. M. 2023. Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions. Translational Psychiatry 13, article number: 7. (10.1038/s41398-022-02296-z)
2022
- Alsaqati, M. et al. 2022. NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia. Translational Psychiatry 12, article number: 438. (10.1038/s41398-022-02199-z)
- Egger, J. et al. 2022. Editorial: Treatment of psychopathological and neurocognitive disorders in genetic syndromes: In need of multidisciplinary phenotyping and treatment design. Frontiers in Psychiatry 13, article number: 1009376. (10.3389/fpsyt.2022.1009376)
- Wolstencroft, J. et al. 2022. Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE, a UK national cohort study. The Lancet Psychiatry 9(9), pp. 715-724. (10.1016/S2215-0366(22)00207-3)
- Donnelly, N. A. et al. 2022. Sleep EEG in young people with 22q11.2 deletion syndrome: A cross-sectional study of slow-waves, spindles and correlations with memory and neurodevelopmental symptoms. eLife 11, article number: e75482. (10.7554/elife.75482)
- Fiksinski, A. M. et al. 2022. A normative chart for cognitive development in a genetically selected population. Neuropsychopharmacology 47(7), pp. 1379–1386. (10.1038/s41386-021-00988-6)
- Jones, R., van Den Bree, M., Zammit, S. and Taylor, P. 2022. The relationship between the Big Five personality factors, anger-hostility, and alcohol and violence in men and women: A nationally representative cohort of 15,701 young adults. Journal of Interpersonal Violence 37, pp. 11-12. (10.1177/0886260520978178)
- White, L. K. et al. 2022. The COVID-19 pandemic's impact on worry and medical disruptions reported by individuals with chromosome 22q11.2 copy number variants and their caregivers. Journal of Intellectual Disability Research 66(4), pp. 313-322. (10.1111/jir.12918)
- Jacquemont, S. et al. 2022. Genes To Mental Health (G2MH): A framework to map the combined effects of rare and common variants on dimensions of cognition and psychopathology. American Journal of Psychiatry 179(3), pp. 189-203. (10.1176/appi.ajp.2021.21040432)
- Cunningham, A. C., Hall, J., Owen, M. and van den Bree, M. B. M. 2022. Assessment of emotions and behaviour by the Developmental Behaviour Checklist in young people with neurodevelopmental CNVs. Psychological Medicine 52(3), pp. 574-586. (10.1017/S0033291720002330)
- Chapman, G. et al. 2022. Using induced pluripotent stem cells to investigate human neuronal phenotypes in 1q21.1 deletion and duplication syndrome. Molecular Psychiatry 27, pp. 819-830. (10.1038/s41380-021-01182-2)
- Wolstencroft, J. et al. 2022. Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE - The UK National Cohort Study. [Online]. papers.SSRN.com: Elsevier. (10.2139/ssrn.4028542) Available at: http://dx.doi.org/10.2139/ssrn.4028542
- Sønderby, I. et al. 2022. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA Working Groups on CNVs. Human Brain Mapping 43(1), pp. 300-328. (10.1002/hbm.25354)
2021
- Chamberland, M. et al. 2021. Detecting microstructural deviations in individuals with deep diffusion MRI tractometry. Nature Computational Science 1, pp. 598-606. (10.1038/s43588-021-00126-8)
- Cleynen, I. et al. 2021. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Molecular Psychiatry, pp. 4496-4510. (10.1038/s41380-020-0654-3)
- Forsyth, J. K. et al. 2021. Prioritizing genetic contributors to cortical alterations in 22q11.2 deletion syndrome using imaging transcriptomics. Cerebral Cortex 31(7), pp. 3285-3298. (10.1093/cercor/bhab008)
- Modenato, C. et al. 2021. Effects of eight neuropsychiatric copy number variants on human brain structure. Translational Psychiatry 11(1), article number: 399. (10.1038/s41398-021-01490-9)
- Linden, S. C. et al. 2021. The psychiatric phenotypes of 1q21 distal deletion and duplication. Translational Psychiatry 11, article number: 105. (10.1038/s41398-021-01226-9)
- Cunningham, A., Hall, J., Owen, M. and Van den Bree, M. 2021. Coordination difficulties, IQ and psychopathology in children with high-risk Copy Number Variants. Psychological Medicine 51(2), pp. 290-299. (10.1017/S0033291719003210)
- Chawner, S. et al. 2021. A genetics-first approach to dissecting the heterogeneity of autism: phenotypic comparison of autism risk copy number variants. American Journal of Psychiatry 178(1), pp. 77-86. (10.1176/appi.ajp.2020.20010015)
- Sønderby, I. E., Hall, J., Owen, M., Van Den Bree, M., Linden, D., Silva, A. and Doherty, J. 2021. 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Translational Psychiatry 11, article number: 182. (10.1038/s41398-021-01213-0)
2020
- Davies, R. et al. 2020. Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 Deletion Syndrome. Nature Medicine 26, pp. 1912-1918. (10.1038/s41591-020-1103-1)
- Chawner, S. J. R. A. et al. 2020. Pan-European landscape of research into neurodevelopmental copy number variants: a survey by the MINDDS consortium. European Journal of Medical Genetics 63(12), article number: 104093. (10.1016/j.ejmg.2020.104093)
- Villalon-Reina, J. et al. 2020. Altered white matter microstructure in 22q11.2 deletion syndrome: a multi-site diffusion tensor imaging study. Molecular Psychiatry 25, pp. 2818-2831. (10.1038/s41380-019-0450-0)
- Dima, D. C. et al. 2020. Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk. Translational Psychiatry 10, article number: 324. (10.1038/s41398-020-00998-w)
- Sun, D. et al. 2020. Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size. Molecular Psychiatry 25, pp. 1822-1834. (10.1038/s41380-018-0078-5)
- Jones, R., Van Den Bree, M., Zammit, S. and Taylor, P. 2020. Change in the relationship between drinking alcohol and risk of violence among adolescents and young adults: a nationally representative longitudinal study. Alcohol and Alcoholism 55(4), pp. 439-447. (10.1093/alcalc/agaa020)
- Cunningham, A., Fung, W., Massey, T., Hall, J., Owen, M., Van Den Bree, M. and Peall, K. 2020. Movement disorder phenotypes in children with 22q11.2 deletion syndrome. Movement Disorders 35(7), pp. 1272-1274. (10.1002/mds.28078)
- Ching, C. R. et al. 2020. Mapping subcortical brain alterations in 22q11.2 deletion syndrome: effects of seletion size and convergence with idiopathic neuropsychiatric illness. American Journal of Psychiatry 177(7), pp. 589-600. (10.1176/appi.ajp.2019.19060583)
- Drakulic, D. et al. 2020. Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD. Molecular Autism 11(1), article number: 42. (10.1186/s13229-020-00343-4)
- Moulding, H., Bartsch, U., Hall, J., Jones, M., Linden, D., Owen, M. and Van Den Bree, M. 2020. Sleep problems and associations with psychopathology and cognition in young people with 22q11.2 deletion syndrome (22q11.2DS). Psychological Medicine 50, pp. 1191-1202. (10.1017/S0033291719001119)
- van der Meer, D. et al. 2020. Association of copy number variation of the 15q11.2 BP1-BP2 region with cortical and subcortical morphology and cognition. JAMA Psychiatry 77(4), pp. 420-430. (10.1001/jamapsychiatry.2019.3779)
- Eaton, C. B. et al. 2020. Response to letter to editor: 'Knowing when and how to use epilepsy screening questionnaires'. Epilepsia 61(4), pp. 826-827. (10.1111/epi.16463)
- Morrison, S. et al. 2020. Cognitive deficits in childhood, adolescence and adulthood in 22q11.2 deletion syndrome and association with psychopathology. Translational Psychiatry 10, article number: 53. (10.1038/s41398-020-0736-7)
- Rizzo, R., Van Den Bree, M., Challenger, A., Cuthbert, A., Arribas-Ayllon, M., Clarke, A. and Thompson, R. 2020. Co-creating a knowledge base in the “22q11.2 deletion syndrome” community. Journal of Community Genetics 11(1), pp. 101-111. (10.1007/s12687-019-00425-8)
- Zhao, Y. et al. 2020. Complete sequence of the 22q11.2 allele in 1,053 subjects with 22q11.2 deletion syndrome reveals modifiers of conotruncal heart defects. American Journal of Human Genetics 106(1), pp. 26-40. (10.1016/j.ajhg.2019.11.010)
- Chamberland, M. et al. 2020. Tractometry-based anomaly detection for single-subject white matter analysis. Presented at: Medical Imaging with Deep Learning (MIDL 2020), Montréal, Canada, 6-9 July 2020.
2019
- Underwood, J., Kendall, K., Berrett, J., Lewis, C., Anney, R., Van den Bree, M. and Hall, J. 2019. Autism spectrum disorder diagnosis in adults: phenotype and genotype findings from a clinically derived cohort. British Journal of Psychiatry 215(5), pp. 647-653. (10.1192/bjp.2019.30)
- Eaton, C. B. et al. 2019. Prevalence and aetiology of epileptic seizures in young people with 22Q11.2 Deletion syndrome and relationships with other neurodevelopmental disorders. Presented at: SSBP 22nd Educational Day and Research Symposium 2019, Birmingham, England, 4-6 September 2019, Vol. 63. Vol. 9. Wiley pp. 1080., (10.1111/jir.12676)
- Cunningham, A. et al. 2019. Using kinematic analyses to explore sensorimotor control impairments in children with 22q11.2 deletion Syndrome. Journal of Neurodevelopmental Disorders 11, article number: 8. (10.1186/s11689-019-9271-3)
- Chawner, S. J. R. A. et al. 2019. Genotype–phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort study. Lancet Psychiatry 6(6), pp. 493 - 505. (10.1016/S2215-0366(19)30123-3)
- Srinivasan, R., Wolstencroft, J., Erwood, M., Raymond, F. L., Van Den Bree, M., Hall, J. and Skuse, D. 2019. Mental health and behavioural problems in children with XXYY: a comparison with intellectual disabilities. Journal of Intellectual Disability Research 63(5), pp. 477-488. (10.1111/jir.12607)
- Eaton, C. et al. 2019. Epilepsy and seizures in young people with 22q11.2 deletion syndrome: prevalence and links with other neurodevelopmental disorders. Epilepsia 60(5), pp. 818-829. (10.1111/epi.14722)
- Chawner, S., Owen, M. J., Holmans, P., Raymond, L., Skuse, D., Hall, J. and van den Bree, M. 2019. Genotype-phenotype relationships in children with copy number variants associated with high neuropsychiatric risk: Findings from the Intellectual Disability & Mental Health: Assessing the Genomic Impact on Neurodevelopment (IMAGINE-ID) study.. [Online]. BioRxiv. (10.1101/535708) Available at: https://doi.org/10.1101/535708
- Drakesmith, M. et al. 2019. Genetic risk for schizophrenia and developmental delay is associated with shape and microstructure of midline white-matter structures. Translational Psychiatry 9(1), article number: 102. (10.1038/s41398-019-0440-7)
- Niarchou, M. et al. 2019. Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome. Schizophrenia Research 204, pp. 320-325. (10.1016/j.schres.2018.07.044)
- Niarchou, M. et al. 2019. Psychiatric disorders in children with 16p11.2 deletion and duplication. Translational Psychiatry (10.1038/s41398-018-0339-8)
2018
- Brieva, J. et al. 2018. Alternative diffusion anisotropy measures for the investigation of white matter alterations in 22q11.2 deletion syndrome. Presented at: 14th International Symposium on Medical Information Processing and Analysis,, Mazatlán, Mexico, 24-26 October 2018 Presented at Romero, E., Lepore, N. and Brieva, J. eds.14th International Symposium on Medical Information Processing and Analysis, Vol. 10975. Proceedings of SPIE Bellingham, Washington: SPIE pp. 51., (10.1117/12.2513788)
- Chawner, S. J., Niarchou, M., Doherty, J. L., Moss, H., Owen, M. J. and Van Den Bree, M. 2018. The emergence of psychotic experiences in the early adolescence of 22q11.2 Deletion Syndrome. Journal of Psychiatric Research 109, pp. 10-17. (10.1016/j.jpsychires.2018.11.002)
- Zhao, Y. et al. 2018. Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects. American Journal of Medical Genetics Part A 176(10), pp. 2172-2181. (10.1002/ajmg.a.40359)
- Morrison, S., Chawner, S., van Amelsvoort, T., Swillen, A., Vergaelen, E., Owen, M. and Van Den Bree, M. 2018. Vulnerable periods for cognitive development in individuals at high genomic risk of schizophrenia [Conference Abstract]. Schizophrenia Bulletin 44(suppl), pp. S86. (10.1093/schbul/sby015.214)
- Cunningham, A. C. et al. 2018. Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome. British Journal of Psychiatry 212(1), pp. 27-33. (10.1192/bjp.2017.6)
2017
- Bassett, A. S. et al. 2017. Rare genome-wide copy number variation and expression of schizophrenia in 22q11.2 deletion syndrome. American Journal of Psychiatry 174(11), pp. 1054-1063. (10.1176/appi.ajp.2017.16121417)
- Demaerel, W. et al. 2017. Nested inversion polymorphisms predispose chromosome 22q11.2 to meiotic rearrangements [RETRACTED]. American Journal of Human Genetics 101(4), pp. 616-622. (10.1016/j.ajhg.2017.09.002)
- Chawner, S., Doherty, J. L., Moss, H., Niarchou, M., Walters, J., Owen, M. J. and Van Den Bree, M. B. 2017. Childhood cognitive development in 22q11.2 deletion syndrome: case–control study. British Journal of Psychiatry 211(4), pp. 223-230. (10.1192/bjp.bp.116.195651)
- Weisman, O. et al. 2017. Subthreshold psychosis in 22q11.2 deletion syndrome: multisite naturalistic study. Schizophrenia Bulletin 43(5), pp. 1079-1089. (10.1093/schbul/sbx005)
- Weisman, O., Guri, Y., Gur, R., McDonald-McGinn, D., Calkins, M. and Van Den Bree, M. 2017. Lithium use in pregnancy and the risk of cardiac malformations. New England Journal of Medicine 377(9), pp. 893-894. (10.1056/NEJMc1708919)
- Gur, R. et al. 2017. A neurogenetic model for the study of schizophrenia spectrum disorders: The International 22q11.2 Deletion Syndrome Brain Behavior Consortium. Molecular Psychiatry 22, pp. 1664-1672.
- Johnston, H. R. et al. 2017. PEMapper and PECaller provide a simplified approach to whole-genome sequencing. Proceedings of the National Academy of Sciences of the United States of America 114(10), pp. E1923-E1932. (10.1073/pnas.1618065114)
2016
- Johnston, J., Linden, D. E. J. and Van Den Bree, M. B. 2016. Combining stress and dopamine based models of addiction: towards a psycho-neuro-endocrinological theory of addiction. Current Drug Abuse Reviews 9(1), pp. 61-74. (10.2174/1874473709666151209113913)
- D'Angelo, D. et al. 2016. Defining the Effect of the 16p11.2 Duplication on Cognition, Behavior, and Medical Comorbidities. JAMA Psychiatry 73(1), pp. 20-30. (10.1001/jamapsychiatry.2015.2123)
2015
- Maillard, A. M. et al. 2015. 16p11.2 Locus modulates response to satiety before the onset of obesity. International Journal of Obesity 40(5), pp. 870-876. (10.1038/ijo.2015.247)
- Niarchou, M., Martin, J., Thapar, A., Owen, M. J. and van den Bree, M. B. 2015. The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168(8), pp. 730-738. (10.1002/ajmg.b.32378)
- Hodgson, K., Shelton, K. H. and van den Bree, M. B. 2015. Psychopathology among young homeless people: Longitudinal mental health outcomes for different subgroups. British Journal of Clinical Psychology 54(3), pp. 307-325. (10.1111/bjc.12075)
- Pesola, F., Shelton, K. H., Heron, J., Munafò, M., Hickman, M. and van den Bree, M. B. 2015. The developmental relationship between depressive symptoms in adolescence and harmful drinking in emerging adulthood: the role of peers and parents. Journal of Youth and Adolescence 44(9), pp. 1752-66. (10.1007/s10964-015-0295-z)
- Vorstman, J. A. S. et al. 2015. Cognitive decline preceding the onset of psychosis in patients with 22q11.2 deletion syndrome. JAMA Psychiatry 72(4), pp. 377-385. (10.1001/jamapsychiatry.2014.2671)
- Pesola, F., Shelton, K. H., Heron, J., Munafo, M., Maughan, B., Hickman, M. and Van Den Bree, M. B. 2015. The mediating role of deviant peers on the link between depressed mood and harmful drinking. Journal of Adolescent Health 56(2), pp. 153-159. (10.1016/j.jadohealth.2014.10.268)
2014
- Pesola, F., Shelton, K. H. and van den Bree, M. B. M. 2014. Sexual orientation and alcohol problem use among UK adolescents: an indirect link through depressed mood. Addiction 109(7), pp. 1072-1080. (10.1111/add.12528)
- Hodgson, K., Shelton, K. and Van Den Bree, M. 2014. Mental health problems in young people with experiences of homelessness and the relationship with health service use: a follow-up study. Evidence-Based Mental Health 17(3), pp. 76-80. (10.1136/eb-2014-101810)
- Niarchou, M., Zammit, S., Escott-Price, V., Owen, M. J. and van den Bree, M. B. 2014. Exploring the indirect effects of catechol-O-methyltransferase (COMT) genotype on psychotic experiences through cognitive function and anxiety disorders in a large birth cohort of children. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 165(5), pp. 410-420. (10.1002/ajmg.b.32245)
- Schneider, M. et al. 2014. Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: Results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome. American Journal of Psychiatry 171(6), pp. 627-639. (10.1176/appi.ajp.2013.13070864)
- Monks, S. et al. 2014. Further evidence for high rates of schizophrenia in 22q11.2 deletion syndrome. Schizophrenia Research 153(1-3), pp. 231-236. (10.1016/j.schres.2014.01.020)
- Di Florio, A., Craddock, N. J. and van den Bree, M. B. 2014. Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates. European Psychiatry 29(3), pp. 117-24. (10.1016/j.eurpsy.2013.07.004)
- Niarchou, M., Zammit, S., van Goozen, S. H. M., Thapar, A., Tierling, H. M., Owen, M. J. and van den Bree, M. B. M. 2014. Psychopathology and cognition in children with 22q11.2 deletion syndrome. British Journal of Psychiatry 204(1), pp. 46-54. (10.1192/bjp.bp.113.132324)
2013
- Moore, S. C., Crompton, K., van Goozen, S. H. M., van den Bree, M. B., Bunney, J. and Lydall, E. S. 2013. A feasibility study of short message service text messaging as a surveillance tool for alcohol consumption and vehicle for interventions in University students. BMC Public Health 13, article number: 1011. (10.1186/1471-2458-13-1011)
- van den Bree, M. B., Miller, G., Mansell, E., Thapar, A., Flinter, F. and Owen, M. J. 2013. The internet is parents' main source of information about psychiatric manifestations of 22q11.2 deletion syndrome (22q11.2DS). European Journal of Medical Genetics 56(8), pp. 439-441. (10.1016/j.ejmg.2013.05.001)
- Niarchou, M., Zammit, S., Walters, J. T. R., Lewis, G., Owen, M. J. and van den Bree, M. B. 2013. Defective processing speed and nonclinical psychotic experiences in children: longitudinal analyses in a large birth cohort. American Journal of Psychiatry 170(5), pp. 550-557. (10.1176/appi.ajp.2012.12060792)
- Delio, M. et al. 2013. Enhanced maternal origin of the 22q11.2 deletion in velocardiofacial and DiGeorge syndromes. American Journal of Human Genetics 92(3), pp. 439-447. (10.1016/j.ajhg.2013.01.018)
- Hodgson, K., Shelton, K. H., van den Bree, M. B. and Los, F. J. 2013. Psychopathology in young people experiencing homelessness: A systematic review. American Journal of Public Health 103(6), pp. e24-e37. (10.2105/AJPH.2013.301318)
- Hummel, A., Shelton, K. H., Heron, J., Moore, L. A. R. and van den Bree, M. B. 2013. A systematic review of the relationships between family functioning, pubertal timing and adolescent substance use. Addiction 108(3), pp. 487-496. (10.1111/add.12055)
2012
- Taberner, J., Fullana, M. A., Caseras, X., Pertusa, A., Bados, A., van den Bree, M. B. and Torrubia, R. 2012. Familial predictors of obsessive-compulsive symptom dimensions (contamination/cleaning and symmetry/ordering) in a nonclinical sample. Journal of Clinical Psychology 68(12), pp. 1266-1275. (10.1002/jclp.21861)
- Ware, J. J., van den Bree, M. B. and Munafo, M. R. 2012. From men to mice: CHRNA5/CHRNA3, smoking behavior and disease. Nicotine & Tobacco Research 14(11), pp. 1291-1299. (10.1093/ntr/nts106)
- Saraceno, L., Heron, J., Munafò, M., Craddock, N. J. and van den Bree, M. B. 2012. The relationship between childhood depressive symptoms and problem alcohol use in early adolescence: findings from a large longitudinal population-based study. Addiction 107(3), pp. 567-577. (10.1111/j.1360-0443.2011.03662.x)
- Shelton, K. H., Mackie, P. K., van den Bree, M. B., Taylor, P. J. and Evans, S. L. 2012. Opening doors for all American youth? Evidence for Federal homelessness policy. Housing Policy Debate 22(3), pp. 483-504. (10.1080/10511482.2012.683034)
2011
- Harold, G. T., Rice, F., Hay, D. F., Boivin, J., van den Bree, M. B. and Thapar, A. 2011. Familial transmission of depression and antisocial behavior symptoms: Disentangling the contribution of inherited and environmental factors and testing the mediating role of parenting. Psychological Medicine 41(6), pp. 1175-1185. (10.1017/S0033291710001753)
- Ware, J. J., van den Bree, M. B. and Munafo, M. R. 2011. Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. Nicotine & Tobacco Research 13(12), pp. 1167-1175. (10.1093/ntr/ntr118)
- Jones, R. M., Arlidge, J. W., Gillham, R., Reagu, S. M., van den Bree, M. B. and Taylor, P. J. 2011. Efficacy of mood stabilisers in the treatment of impulsive or repetitive aggression: systematic review and meta-analysis. British Journal of Psychiatry 198(2), pp. 93-98. (10.1192/bjp.bp.110.083030)
2010
- Thapar, A. et al. 2010. Response to: testing the association between smoking in pregnancy and attention-deficit/hyperactivity disorder in a novel design [Letter]. Biological psychiatry 68(4), pp. e13-e14. (10.1016/j.biopsych.2010.01.032)
- Glaser, B., Shelton, K. H. and van den Bree, M. B. 2010. The moderating role of close friends in the relationship between conduct problems and adolescent substance use. Journal of Adolescent Health 47(1), pp. 35-42. (10.1016/j.jadohealth.2009.12.022)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196(3), pp. 235-240. (10.1192/bjp.bp.109.066274)
- Rice, F., Harold, G. T., Boivin, J., van den Bree, M. B., Hay, D. F. and Thapar, A. 2010. The links between prenatal stress and offspring development and psychopathology: Disentangling environmental and inherited influences. Psychological Medicine 40(2), pp. 335-345. (10.1017/S0033291709005911)
- Shelton, K. H. and van den Bree, M. B. 2010. The Moderating Effects of Pubertal Timing on the Longitudinal Associations Between Parent-Child Relationship Quality and Adolescent Substance Use. Journal of Research on Adolescence 20(4), pp. 1044-1064. (10.1111/j.1532-7795.2010.00643.x)
2009
- van den Bree, M. B., Shelton, K. H., Bonner, A., Moss, S., Thomas, H. V. and Taylor, P. J. 2009. A longitudinal population-based study of factors in adolescence predicting homelessness in young adulthood. Journal of Adolescent Health 45(6), pp. 571-578. (10.1016/j.jadohealth.2009.03.027)
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19(6), pp. 312-319. (10.1097/YPG.0b013e3283328df4)
- Thapar, A. et al. 2009. Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel design. Biological Psychiatry 66(8), pp. 722-727. (10.1016/j.biopsych.2009.05.032)
- Taberner, J. et al. 2009. Are obsessive-compulsive symptom dimensions familial in nonclinical individuals?. Depression and Anxiety 26(10), pp. 902-908. (10.1002/da.20606)
- Shelton, K. H., Boivin, J., Hay, D. F., van den Bree, M. B., Rice, F., Harold, G. T. and Thapar, A. 2009. Examining differences in psychological adjustment problems among children conceived by assisted reproductive technologies. International Journal of Behavioral Development 33(5), pp. 385-392. (10.1177/0165025409338444)
- Saraceno, L., Munafó, M., Heron, J., Craddock, N. J. and van den Bree, M. B. 2009. Genetic and non-genetic influences on the development of co-occurring alcohol problem use and internalizing symptomatology in adolescence: a review. Addiction 104(7), pp. 1100-1121. (10.1111/j.1360-0443.2009.02571.x)
- Boivin, J., Rice, F., Hay, D. F., Harold, G. T., Lewis, A., van den Bree, M. B. and Thapar, A. 2009. Associations between maternal older age, family environment and parent and child wellbeing in families using assisted reproductive techniques to conceive. Social Science & Medicine 68(11), pp. 1948-1955. (10.1016/j.socscimed.2009.02.036)
- Shelton, K. H., Taylor, P. J., Bonner, A. and van den Bree, M. B. 2009. Risk Factors for Homelessness: Evidence From a Population-Based Study. Psychiatric Services 60(4), pp. 465-472. (10.1176/appi.ps.60.4.465)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
- Jones, R. M., van den Bree, M. B., Ferriter, M. and Taylor, P. J. 2009. Childhood risk factors for offending before first psychiatric admission for people with schizophrenia: a case-control study of high security hospital admissions. Behavioral Sciences & the Law 28(3), pp. 351-365. (10.1002/bsl.885)
- Rice, F., Harold, G. T., Boivin, J., Hay, D. F., van den Bree, M. B. and Thapar, A. 2009. Disentangling prenatal and inherited influences in humans with an experimental design. Proceedings of the National Academy of Sciences of the United States of America 106(7), pp. 2464-2467. (10.1073/pnas.0808798106)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
2008
- Shelton, K. H., Harold, G. T., Fowler, T. A., Rice, F., Neale, M. C., Thapar, A. and van den Bree, M. B. 2008. Parent-Child Relations, Conduct Problems and Cigarette Use in Adolescence: Examining the Role of Genetic and Environmental Factors on Patterns of Behavior. Journal of Youth and Adolescence 37(10), pp. 1216-1228. (10.1007/s10964-007-9254-7)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
- Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17(8), pp. 1169-1174. (10.1093/hmg/ddn006)
- Harold, G. T., Shelton, K. H., Rice, F., Boivin, J., Hay, D. F., van den Bree, M. B. and Thapar, A. 2008. Disentangling genetic and environmental influences on children’s development: introducing a novel methodology. Acta Psychologica Sinica 40(10), pp. 1124-1134.
2007
- Rice, F. et al. 2007. Genetic and environmental transmission of anxiety and depression in families using a novel design [Abstract]. Behavior Genetics 37(6), pp. 788-788. (10.1007/s10519-007-9169-9)
- van den Bree, M. B. 2007. Genes, Environment, and Psychopathology: Understanding the Causes of Psychiatric and Substance Use Disorders [Book Review]. Psychological Medicine 37(7), pp. 1061-1061. (10.1017/S0033291707000037)
- Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry 7(1), pp. 26-26. (10.1186/1471-244X-7-26)
- Fowler, T. A. et al. 2007. Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. Addiction 102(3), pp. 413-422. (10.1111/j.1360-0443.2006.01694.x)
- Shelton, K. H., Lifford, K., Fowler, T., Rice, F., Harold, G. T., Thapar, A. and van den Bree, M. B. 2007. The association between conduct problems and the initiation and progression of marijuana use during adolescence: A genetic analysis across time. Behavior Genetics 37(2), pp. 314-325. (10.1007/s10519-006-9124-1)
- van den Bree, M. B. et al. 2007. The Cardiff Study of All Wales and North West of England Twins (CaStANET): A longitudinal research program of child and adolescent development. Twin Research and Human Genetics 10(1), pp. 13-23. (10.1375/twin.10.1.13)
- Thapar, A. et al. 2007. Do intrauterine or genetic influences explain the foetal origins of chronic disease? A novel experimental method for disentangling effects. BMC Medical Research Methodology 7(1), pp. 25-32. (10.1186/1471-2288-7-25)
- Fowler, T. et al. 2007. Genetic and environmental influences on the relationship between peer alcohol use and own alcohol use in adolescents. Addiction 102(6), pp. 894-903. (10.1111/j.1360-0443.2007.01824.x)
- Rice, F. et al. 2007. Agreement between maternal report and antenatal records for a range of pre and peri-natal factors: The influence of maternal and child characteristics. Early Human Development 83(8), pp. 497-504. (10.1016/j.earlhumdev.2006.09.015)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
2006
- Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(7), pp. 723-724.
- McMurran, M., Egan, V., Cusens, B., van den Bree, M. B., Austin, E. and Charlesworth, P. 2006. The Alcohol-related Aggression Questionnaire. Addiction Research and Theory 14(3), pp. 323-343. (10.1080/16066353600608646)
- van den Bree, M. B., Przybeck, T. R. and Robert Cloninger, C. 2006. Diet and personality: Associations in a population-based sample. Appetite 46(2), pp. 177-188. (10.1016/j.appet.2005.12.004)
- Thapar, A., van den Bree, M. B., Fowler, T., Langley, K. and Whittinger, N. 2006. Predictors of antisocial behaviour in children with attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 15(2), pp. 118-125. (10.1007/s00787-006-0511-1)
2005
- Langley, K., Rice, F., van den Bree, M. B. and Thapar, A. 2005. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.. Minerva Pediatrica 57(6), pp. 359-371.
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
- Bergen, A. W. et al. 2005. Association of multiple DRD2 polymorphisms with anorexia nervosa. Neuropsychopharmacology 30(9), pp. 1703-1710. (10.1038/sj.npp.1300719)
- Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
- van den Bree, M. B. 2005. Combining research approaches to advance our understanding of drug addiction. Current Psychiatry Reports 7(2), pp. 125-132. (10.1007/s11920-005-0009-4)
- van den Bree, M. B. and Pickworth, W. B. 2005. Risk factors predicting changes in marijuana involvement in teenagers. Archives of General Psychiatry 62(3), pp. 311-319. (10.1001/archpsyc.62.3.311)
- Cope, N. A. et al. 2005. No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia. Molecular Psychiatry 10(3), pp. 237-238. (10.1038/sj.mp.4001596)
2004
- Rice, F., van den Bree, M. B. and Thapar, A. 2004. A population-based study of anxiety as a precursor for depression in childhood and adolescence. BMC Psychiatry 4, article number: 43. (10.1186/1471-244X-4-43)
- Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
- van den Bree, M. B., Whitmer, M. D. and Pickworth, W. B. 2004. Predictors of smoking development in a population-based sample of adolescents: A prospective study. Journal of Adolescent Health 35(3), pp. 172-181. (10.1016/j.jadohealth.2003.09.021)
- Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
- Scourfield, J., van den Bree, M. B., Martin, N. and McGuffin, P. 2004. Conduct problems in children and adolescents: a twin study. Archives of General Psychiatry 61(5), pp. 489-496. (10.1001/archpsyc.61.5.489)
- Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)
2003
- Thapar, A. et al. 2003. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. American Journal of Psychiatry 160(11), pp. 1985-1989. (10.1176/appi.ajp.160.11.1985)
- Thapar, A. et al. 2003. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. American Journal of Psychiatry 160(11), pp. 1985-1989. (10.1176/appi.ajp.160.11.1985)
- Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
- Thapar, A. et al. 2003. Maternal smoking in pregnancy and attention deficit hyperactivity disorder symptoms in offspring. Behavior Genetics 33(6), pp. 720-721.
- Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
- Bergen, A. et al. 2003. Candidate genes for anorexia nervosa in the 1p33-36 linkage region: Serotonin 1D and delta opioid receptors display significant association to anorexia nervosa [Conference Abstract]. Biological Psychiatry 53(8), pp. 165S-165S. (10.1016/S0006-3223(03)00164-1)
- Bergen, A. W. et al. 2003. Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. Molecular Psychiatry 8(4), pp. 397-406. (10.1038/sj.mp.4001318)
- Bergen, A. et al. 2003. Candidate Gene Analysis of the Price Foundation Anorexia Nervosa Affected Relative Pair Dataset. Current Drug Target -CNS & Neurological Disorders 2(1), pp. 41-51. (10.2174/1568007033338760)
- Turic, D. et al. 2003. Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22. Molecular Psychiatry 8(2), pp. 176-185. (10.1038/sj.mp.4001216)
- van den Bree, M. B. and Owen, M. J. 2003. The future of psychiatric genetics. Annals of Medicine 35(2), pp. 122-134. (10.1080/07853890310010023)
2002
- Miles, D. R., van den Bree, M. B. and Pickens, R. W. 2002. Sex differences in shared genetic and environmental influences between conduct disorder symptoms and marijuana use in adolescents. American Journal of Medical Genetics 114(2), pp. 159-168. (10.1002/ajmg.10178)
2001
- Miles, D. R., van den Bree, M. B., Gupman, A. E., Newlin, D. B., Glantz, M. D. and Pickens, R. W. 2001. A twin study on sensation seeking, risk taking behavior and marijuana use. Drug and Alcohol Dependence 62(1), pp. 57-68. (10.1002/ajmg.b.32352)
- Pickens, R. W. et al. 2001. Family history influence on drug abuse severity and treatment outcome. Drug and Alcohol Dependence 61(3), pp. 261-270. (10.1016/S0376-8716(00)00146-0)
2000
- Newlin, D. B., Miles, D. R., van den Bree, M. B., Gupman, A. E. and Pickens, R. W. 2000. Environmental transmission of DSM-IV substance use disdorders in adoptive and step families. Alcoholism-Clinical and Experimental Research 24(12), pp. 1785-1794. (10.1111/j.1530-0277.2000.tb01982.x)
1999
- van den Bree, M. B., Eaves, L. J. and Dwyer, J. T. 1999. Genetic and environmental influences on eating patterns of twins aged >/=50 y. American Journal of Clinical Nutrition 70(4), pp. 456-465.
1998
- van den Bree, M. B., Johnson, E. O., Neale, M. C. and Pickens, R. W. 1998. Genetic and environmental influences on drug use and abuse/dependence in male and female twins. Drug and Alcohol Dependence 52(3), pp. 231-241. (10.1016/S0376-8716(98)00101-X)
- Johnson, E. O., van den Bree, M. B., Gupman, A. E. and Pickens, R. W. 1998. Extension of a typology of alcohol dependence based on relative genetic and environmental loading. Alcoholism-Clinical and Experimental Research 22(7), pp. 1421-1429. (10.1111/j.1530-0277.1998.tb03930.x)
- van den Bree, M. B., Svikis, D. S. and Pickens, R. W. 1998. Genetic influences in antisocial personality and drug use disorders. Drug and Alcohol Dependence 49(3), pp. 177-187. (10.1016/S0376-8716(98)00012-X)
- van den Bree, M. B., Johnson, E. O., Neale, M. C., Svikis, D. S., McGue, M. and Pickens, R. W. 1998. Genetic analysis of diagnostic systems of alcoholism in males. Biological psychiatry 43(2), pp. 139-145. (10.1016/S0006-3223(97)00225-4)
1996
- Johnson, E. O., van den Bree, M. B. and Pickens, R. W. 1996. Subtypes of alcohol-dependent men: a typology based on relative genetic and environmental loading. Alcoholism-Clinical and Experimental Research 20(8), pp. 1472-1480. (10.1111/j.1530-0277.1996.tb01151.x)
- van den Bree, M. B., Schieken, R. M., Moskowitz, W. M. and Eaves, L. J. 1996. Genetic regulation of hemodynamic variables during dynamic exercise. The MCV twin study. Circulation 94(8), pp. 1864-1869. (10.1161/01.CIR.94.8.1864)
- Johnson, E. O., van den Bree, M. B., Uhl, G. R. and Pickens, R. W. 1996. Indicators of genetic and environmental influences in drug abusing individuals. Drug and Alcohol Dependence 41(1), pp. 17-23. (10.1016/0376-8716(96)01223-9)
- Johnson, E. O., van den Bree, M. B. and Pickens, R. W. 1996. Indicators of genetic and environmental influence in alcohol-dependent individuals. Alcoholism-Clinical and Experimental Research 20(1), pp. 67-74. (10.1111/j.1530-0277.1996.tb01046.x)
1990
- Keuss, P., van der Zee, F. and van den Bree, M. B. 1990. Auditory accessory effects on visual processing. Acta Psychologica 75(1), pp. 41-54. (10.1016/0001-6918(90)90065-N)
- Passchier, J., van den Bree, M. B., Emmen, H., Osterhaus, S., Orlebeke, J. and Verhage, F. 1990. Relaxation Training in School Classes Does Not Reduce Headache Complaints. Headache 30(10), pp. 660-664. (10.1111/j.1526-4610.1990.hed3010660.x)
- van den Bree, M. B., Passchier, J. and Emmen, H. 1990. Influence of Quality of Life and Stress Coping Behaviour on Headaches in Adolescent Male Students: an Explorative Study. Headache 30(3), pp. 165-168. (10.1111/j.1526-4610.1990.hed3003165.x)
1989
- Boomsma, D. I., van den Bree, M. B., Orlebeke, J. F. and Molenaar, P. C. M. 1989. Resemblances of parents and twins in sports participation and heart rate. Behavior Genetics 19(1), pp. 123-141. (10.1007/BF01065888)
- Passchier, J., van den Bree, M. B., Leijdekkers, M. and Verhage, F. 1989. Development of a short instrument for the measurement of self-aggression. Preliminary results in female migraine patients. Psychotherapy and Psychosomatics 52(4), pp. 205-208.
Articles
- Rammos, A. et al. 2025. Copy number variants and their implications for developmental and behavioural problems in cleft lip and/or palate. Human Molecular Genetics, article number: ddaf115. (10.1093/hmg/ddaf115)
- Katzourou, I. et al. 2025. Contributions of common and rare genetic variation to different measures of mood and anxiety disorder in UK Biobank. BJPsych Open 11(3), article number: e97. (10.1192/bjo.2025.43)
- Silva, A. et al. 2025. Penetrance of neurodevelopmental copy number variants is associated with variations in cortical morphology. Biological Psychiatry (10.1016/j.bpsc.2025.05.010)
- Lee, I. et al. 2025. Inequalities of the waiting time for education health and care plan provision for pupils with intellectual developmental disabilities: a brief report. Journal of Intellectual Disability Research (10.1111/jir.13239)
- Gur, R. C. et al. 2025. Neurocognitive profiles of 22q11.2 and 16p11.2 deletions and duplications. Molecular Psychiatry 30, pp. 379-387. (10.1038/s41380-024-02661-y)
- Ali, N. M. et al. 2025. Comparison of autism domains across thirty rare variant genotypes. EBioMedicine 112, article number: 105521. (10.1016/j.ebiom.2024.105521)
- Lee, I. O. et al. 2024. The inequity of education, health and care plan provision for children and young people with intellectual and developmental disabilities. Journal of Intellectual Disability Research 68(10), pp. 1167-1183. (10.1111/jir.13139)
- Hall, J. H. et al. 2024. Irritability in young people with copy number variants associated with neurodevelopmental disorders (ND-CNVs). Translational Psychiatry 14(1), article number: 259. (10.1038/s41398-024-02975-z)
- Kopal, J. et al. 2024. Using rare genetic mutations to revisit structural brain asymmetry. Nature Communications 15(1), article number: 2639. (10.1038/s41467-024-46784-w)
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- Thapar, A. et al. 2009. Prenatal smoking might not cause Attention-Deficit/Hyperactivity Disorder: Evidence from a novel design. Biological Psychiatry 66(8), pp. 722-727. (10.1016/j.biopsych.2009.05.032)
- Taberner, J. et al. 2009. Are obsessive-compulsive symptom dimensions familial in nonclinical individuals?. Depression and Anxiety 26(10), pp. 902-908. (10.1002/da.20606)
- Shelton, K. H., Boivin, J., Hay, D. F., van den Bree, M. B., Rice, F., Harold, G. T. and Thapar, A. 2009. Examining differences in psychological adjustment problems among children conceived by assisted reproductive technologies. International Journal of Behavioral Development 33(5), pp. 385-392. (10.1177/0165025409338444)
- Saraceno, L., Munafó, M., Heron, J., Craddock, N. J. and van den Bree, M. B. 2009. Genetic and non-genetic influences on the development of co-occurring alcohol problem use and internalizing symptomatology in adolescence: a review. Addiction 104(7), pp. 1100-1121. (10.1111/j.1360-0443.2009.02571.x)
- Boivin, J., Rice, F., Hay, D. F., Harold, G. T., Lewis, A., van den Bree, M. B. and Thapar, A. 2009. Associations between maternal older age, family environment and parent and child wellbeing in families using assisted reproductive techniques to conceive. Social Science & Medicine 68(11), pp. 1948-1955. (10.1016/j.socscimed.2009.02.036)
- Shelton, K. H., Taylor, P. J., Bonner, A. and van den Bree, M. B. 2009. Risk Factors for Homelessness: Evidence From a Population-Based Study. Psychiatric Services 60(4), pp. 465-472. (10.1176/appi.ps.60.4.465)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
- Jones, R. M., van den Bree, M. B., Ferriter, M. and Taylor, P. J. 2009. Childhood risk factors for offending before first psychiatric admission for people with schizophrenia: a case-control study of high security hospital admissions. Behavioral Sciences & the Law 28(3), pp. 351-365. (10.1002/bsl.885)
- Rice, F., Harold, G. T., Boivin, J., Hay, D. F., van den Bree, M. B. and Thapar, A. 2009. Disentangling prenatal and inherited influences in humans with an experimental design. Proceedings of the National Academy of Sciences of the United States of America 106(7), pp. 2464-2467. (10.1073/pnas.0808798106)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
- Shelton, K. H., Harold, G. T., Fowler, T. A., Rice, F., Neale, M. C., Thapar, A. and van den Bree, M. B. 2008. Parent-Child Relations, Conduct Problems and Cigarette Use in Adolescence: Examining the Role of Genetic and Environmental Factors on Patterns of Behavior. Journal of Youth and Adolescence 37(10), pp. 1216-1228. (10.1007/s10964-007-9254-7)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
- Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17(8), pp. 1169-1174. (10.1093/hmg/ddn006)
- Harold, G. T., Shelton, K. H., Rice, F., Boivin, J., Hay, D. F., van den Bree, M. B. and Thapar, A. 2008. Disentangling genetic and environmental influences on children’s development: introducing a novel methodology. Acta Psychologica Sinica 40(10), pp. 1124-1134.
- Rice, F. et al. 2007. Genetic and environmental transmission of anxiety and depression in families using a novel design [Abstract]. Behavior Genetics 37(6), pp. 788-788. (10.1007/s10519-007-9169-9)
- van den Bree, M. B. 2007. Genes, Environment, and Psychopathology: Understanding the Causes of Psychiatric and Substance Use Disorders [Book Review]. Psychological Medicine 37(7), pp. 1061-1061. (10.1017/S0033291707000037)
- Langley, K., Holmans, P. A., van den Bree, M. B. and Thapar, A. 2007. Effects of low birth weight, maternal smoking in pregnancy and social class on the phenotypic manifestation of Attention Deficit Hyperactivity Disorder and associated antisocial behaviour: investigation in a clinical sample. BMC Psychiatry 7(1), pp. 26-26. (10.1186/1471-244X-7-26)
- Fowler, T. A. et al. 2007. Exploring the relationship between genetic and environmental influences on initiation and progression of substance use. Addiction 102(3), pp. 413-422. (10.1111/j.1360-0443.2006.01694.x)
- Shelton, K. H., Lifford, K., Fowler, T., Rice, F., Harold, G. T., Thapar, A. and van den Bree, M. B. 2007. The association between conduct problems and the initiation and progression of marijuana use during adolescence: A genetic analysis across time. Behavior Genetics 37(2), pp. 314-325. (10.1007/s10519-006-9124-1)
- van den Bree, M. B. et al. 2007. The Cardiff Study of All Wales and North West of England Twins (CaStANET): A longitudinal research program of child and adolescent development. Twin Research and Human Genetics 10(1), pp. 13-23. (10.1375/twin.10.1.13)
- Thapar, A. et al. 2007. Do intrauterine or genetic influences explain the foetal origins of chronic disease? A novel experimental method for disentangling effects. BMC Medical Research Methodology 7(1), pp. 25-32. (10.1186/1471-2288-7-25)
- Fowler, T. et al. 2007. Genetic and environmental influences on the relationship between peer alcohol use and own alcohol use in adolescents. Addiction 102(6), pp. 894-903. (10.1111/j.1360-0443.2007.01824.x)
- Rice, F. et al. 2007. Agreement between maternal report and antenatal records for a range of pre and peri-natal factors: The influence of maternal and child characteristics. Early Human Development 83(8), pp. 497-504. (10.1016/j.earlhumdev.2006.09.015)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
- Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(7), pp. 723-724.
- McMurran, M., Egan, V., Cusens, B., van den Bree, M. B., Austin, E. and Charlesworth, P. 2006. The Alcohol-related Aggression Questionnaire. Addiction Research and Theory 14(3), pp. 323-343. (10.1080/16066353600608646)
- van den Bree, M. B., Przybeck, T. R. and Robert Cloninger, C. 2006. Diet and personality: Associations in a population-based sample. Appetite 46(2), pp. 177-188. (10.1016/j.appet.2005.12.004)
- Thapar, A., van den Bree, M. B., Fowler, T., Langley, K. and Whittinger, N. 2006. Predictors of antisocial behaviour in children with attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 15(2), pp. 118-125. (10.1007/s00787-006-0511-1)
- Langley, K., Rice, F., van den Bree, M. B. and Thapar, A. 2005. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review.. Minerva Pediatrica 57(6), pp. 359-371.
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
- Bergen, A. W. et al. 2005. Association of multiple DRD2 polymorphisms with anorexia nervosa. Neuropsychopharmacology 30(9), pp. 1703-1710. (10.1038/sj.npp.1300719)
- Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
- van den Bree, M. B. 2005. Combining research approaches to advance our understanding of drug addiction. Current Psychiatry Reports 7(2), pp. 125-132. (10.1007/s11920-005-0009-4)
- van den Bree, M. B. and Pickworth, W. B. 2005. Risk factors predicting changes in marijuana involvement in teenagers. Archives of General Psychiatry 62(3), pp. 311-319. (10.1001/archpsyc.62.3.311)
- Cope, N. A. et al. 2005. No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia. Molecular Psychiatry 10(3), pp. 237-238. (10.1038/sj.mp.4001596)
- Rice, F., van den Bree, M. B. and Thapar, A. 2004. A population-based study of anxiety as a precursor for depression in childhood and adolescence. BMC Psychiatry 4, article number: 43. (10.1186/1471-244X-4-43)
- Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
- van den Bree, M. B., Whitmer, M. D. and Pickworth, W. B. 2004. Predictors of smoking development in a population-based sample of adolescents: A prospective study. Journal of Adolescent Health 35(3), pp. 172-181. (10.1016/j.jadohealth.2003.09.021)
- Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
- Scourfield, J., van den Bree, M. B., Martin, N. and McGuffin, P. 2004. Conduct problems in children and adolescents: a twin study. Archives of General Psychiatry 61(5), pp. 489-496. (10.1001/archpsyc.61.5.489)
- Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)
- Thapar, A. et al. 2003. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. American Journal of Psychiatry 160(11), pp. 1985-1989. (10.1176/appi.ajp.160.11.1985)
- Thapar, A. et al. 2003. Maternal smoking during pregnancy and attention deficit hyperactivity disorder symptoms in offspring. American Journal of Psychiatry 160(11), pp. 1985-1989. (10.1176/appi.ajp.160.11.1985)
- Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
- Thapar, A. et al. 2003. Maternal smoking in pregnancy and attention deficit hyperactivity disorder symptoms in offspring. Behavior Genetics 33(6), pp. 720-721.
- Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
- Bergen, A. et al. 2003. Candidate genes for anorexia nervosa in the 1p33-36 linkage region: Serotonin 1D and delta opioid receptors display significant association to anorexia nervosa [Conference Abstract]. Biological Psychiatry 53(8), pp. 165S-165S. (10.1016/S0006-3223(03)00164-1)
- Bergen, A. W. et al. 2003. Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa. Molecular Psychiatry 8(4), pp. 397-406. (10.1038/sj.mp.4001318)
- Bergen, A. et al. 2003. Candidate Gene Analysis of the Price Foundation Anorexia Nervosa Affected Relative Pair Dataset. Current Drug Target -CNS & Neurological Disorders 2(1), pp. 41-51. (10.2174/1568007033338760)
- Turic, D. et al. 2003. Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22. Molecular Psychiatry 8(2), pp. 176-185. (10.1038/sj.mp.4001216)
- van den Bree, M. B. and Owen, M. J. 2003. The future of psychiatric genetics. Annals of Medicine 35(2), pp. 122-134. (10.1080/07853890310010023)
- Miles, D. R., van den Bree, M. B. and Pickens, R. W. 2002. Sex differences in shared genetic and environmental influences between conduct disorder symptoms and marijuana use in adolescents. American Journal of Medical Genetics 114(2), pp. 159-168. (10.1002/ajmg.10178)
- Miles, D. R., van den Bree, M. B., Gupman, A. E., Newlin, D. B., Glantz, M. D. and Pickens, R. W. 2001. A twin study on sensation seeking, risk taking behavior and marijuana use. Drug and Alcohol Dependence 62(1), pp. 57-68. (10.1002/ajmg.b.32352)
- Pickens, R. W. et al. 2001. Family history influence on drug abuse severity and treatment outcome. Drug and Alcohol Dependence 61(3), pp. 261-270. (10.1016/S0376-8716(00)00146-0)
- Newlin, D. B., Miles, D. R., van den Bree, M. B., Gupman, A. E. and Pickens, R. W. 2000. Environmental transmission of DSM-IV substance use disdorders in adoptive and step families. Alcoholism-Clinical and Experimental Research 24(12), pp. 1785-1794. (10.1111/j.1530-0277.2000.tb01982.x)
- van den Bree, M. B., Eaves, L. J. and Dwyer, J. T. 1999. Genetic and environmental influences on eating patterns of twins aged >/=50 y. American Journal of Clinical Nutrition 70(4), pp. 456-465.
- van den Bree, M. B., Johnson, E. O., Neale, M. C. and Pickens, R. W. 1998. Genetic and environmental influences on drug use and abuse/dependence in male and female twins. Drug and Alcohol Dependence 52(3), pp. 231-241. (10.1016/S0376-8716(98)00101-X)
- Johnson, E. O., van den Bree, M. B., Gupman, A. E. and Pickens, R. W. 1998. Extension of a typology of alcohol dependence based on relative genetic and environmental loading. Alcoholism-Clinical and Experimental Research 22(7), pp. 1421-1429. (10.1111/j.1530-0277.1998.tb03930.x)
- van den Bree, M. B., Svikis, D. S. and Pickens, R. W. 1998. Genetic influences in antisocial personality and drug use disorders. Drug and Alcohol Dependence 49(3), pp. 177-187. (10.1016/S0376-8716(98)00012-X)
- van den Bree, M. B., Johnson, E. O., Neale, M. C., Svikis, D. S., McGue, M. and Pickens, R. W. 1998. Genetic analysis of diagnostic systems of alcoholism in males. Biological psychiatry 43(2), pp. 139-145. (10.1016/S0006-3223(97)00225-4)
- Johnson, E. O., van den Bree, M. B. and Pickens, R. W. 1996. Subtypes of alcohol-dependent men: a typology based on relative genetic and environmental loading. Alcoholism-Clinical and Experimental Research 20(8), pp. 1472-1480. (10.1111/j.1530-0277.1996.tb01151.x)
- van den Bree, M. B., Schieken, R. M., Moskowitz, W. M. and Eaves, L. J. 1996. Genetic regulation of hemodynamic variables during dynamic exercise. The MCV twin study. Circulation 94(8), pp. 1864-1869. (10.1161/01.CIR.94.8.1864)
- Johnson, E. O., van den Bree, M. B., Uhl, G. R. and Pickens, R. W. 1996. Indicators of genetic and environmental influences in drug abusing individuals. Drug and Alcohol Dependence 41(1), pp. 17-23. (10.1016/0376-8716(96)01223-9)
- Johnson, E. O., van den Bree, M. B. and Pickens, R. W. 1996. Indicators of genetic and environmental influence in alcohol-dependent individuals. Alcoholism-Clinical and Experimental Research 20(1), pp. 67-74. (10.1111/j.1530-0277.1996.tb01046.x)
- Keuss, P., van der Zee, F. and van den Bree, M. B. 1990. Auditory accessory effects on visual processing. Acta Psychologica 75(1), pp. 41-54. (10.1016/0001-6918(90)90065-N)
- Passchier, J., van den Bree, M. B., Emmen, H., Osterhaus, S., Orlebeke, J. and Verhage, F. 1990. Relaxation Training in School Classes Does Not Reduce Headache Complaints. Headache 30(10), pp. 660-664. (10.1111/j.1526-4610.1990.hed3010660.x)
- van den Bree, M. B., Passchier, J. and Emmen, H. 1990. Influence of Quality of Life and Stress Coping Behaviour on Headaches in Adolescent Male Students: an Explorative Study. Headache 30(3), pp. 165-168. (10.1111/j.1526-4610.1990.hed3003165.x)
- Boomsma, D. I., van den Bree, M. B., Orlebeke, J. F. and Molenaar, P. C. M. 1989. Resemblances of parents and twins in sports participation and heart rate. Behavior Genetics 19(1), pp. 123-141. (10.1007/BF01065888)
- Passchier, J., van den Bree, M. B., Leijdekkers, M. and Verhage, F. 1989. Development of a short instrument for the measurement of self-aggression. Preliminary results in female migraine patients. Psychotherapy and Psychosomatics 52(4), pp. 205-208.
Conferences
- Benger, L., LINC Consortium, ., Holmans, P., Owen, M., Mon-Williams, M., Katzourou, I. and Van den Bree, M. 2024. Adverse childhood experiences and multimorbidity of internalising and cardiometabolic conditions in an older-age population. Presented at: International Population Data Linkage Conference, Chicago, USA, 15-18 September 2025Conference Proceedings for International Population Data Linkage Conference, Vol. 9. Vol. 5. Swansea University pp. 133., (10.23889/ijpds.v9i5.2617)
- Chamberland, M. et al. 2020. Tractometry-based anomaly detection for single-subject white matter analysis. Presented at: Medical Imaging with Deep Learning (MIDL 2020), Montréal, Canada, 6-9 July 2020.
- Eaton, C. B. et al. 2019. Prevalence and aetiology of epileptic seizures in young people with 22Q11.2 Deletion syndrome and relationships with other neurodevelopmental disorders. Presented at: SSBP 22nd Educational Day and Research Symposium 2019, Birmingham, England, 4-6 September 2019, Vol. 63. Vol. 9. Wiley pp. 1080., (10.1111/jir.12676)
- Brieva, J. et al. 2018. Alternative diffusion anisotropy measures for the investigation of white matter alterations in 22q11.2 deletion syndrome. Presented at: 14th International Symposium on Medical Information Processing and Analysis,, Mazatlán, Mexico, 24-26 October 2018 Presented at Romero, E., Lepore, N. and Brieva, J. eds.14th International Symposium on Medical Information Processing and Analysis, Vol. 10975. Proceedings of SPIE Bellingham, Washington: SPIE pp. 51., (10.1117/12.2513788)
Websites
- Wolstencroft, J. et al. 2022. Neuropsychiatric risk in children with intellectual disability of genetic origin: IMAGINE - The UK National Cohort Study. [Online]. papers.SSRN.com: Elsevier. (10.2139/ssrn.4028542) Available at: http://dx.doi.org/10.2139/ssrn.4028542
- Chawner, S., Owen, M. J., Holmans, P., Raymond, L., Skuse, D., Hall, J. and van den Bree, M. 2019. Genotype-phenotype relationships in children with copy number variants associated with high neuropsychiatric risk: Findings from the Intellectual Disability & Mental Health: Assessing the Genomic Impact on Neurodevelopment (IMAGINE-ID) study.. [Online]. BioRxiv. (10.1101/535708) Available at: https://doi.org/10.1101/535708
Ymchwil
Rolau arweiniol
Ymchwil aml-afiachusrwydd LIfespaN Cydweithredol (LINC)
Rwy'n arwain grant rhaglen LINC, gan ddod ag ymchwilwyr o Brifysgolion Caerdydd, Bryste, Leeds, Queen Mary Llundain a Chaerwysg ynghyd a Sefydliad Wellcome Sanger yn y DU yn ogystal â Phrifysgol Roskilde yn Nenmarc. Mae LINC yn astudio datblygiad aml-morbidrwydd iechyd corfforol a meddyliol ar draws y bywyd. Mae'r rhaglen yn cynnwys dadansoddi wyth carfan hydredol fawr (maint sampl cyfunol ~7 miliwn) i werthuso rôl ffactorau genetig ac amgylcheddol ar risg o ddatblygu aml-morbidrwydd.
Profiadau pobl Caerdydd gyda Rhaglen Ymchwil amrywiolion genedigaeth prin (ECHO)
Dechreuais ac arweiniais raglen ymchwil hydredol ar raddfa fawr sy'n astudio iechyd meddwl a chorfforol mewn pobl ag ystod o amrywiolion genomig prin sy'n gysylltiedig â risg uwch o anhwylder niwroddatblygiadol. Mae cyfranogwyr yn cael eu recriwtio trwy glinigau Geneteg Feddygol y DU ac mae aelodau eu teulu hefyd yn cymryd rhan. Mae'r rhaglen hon yn cyfuno ffenoteipio eang manwl gydag astudiaethau genetig, cellog, ffarmacolegol a delweddu'r ymennydd.
DYCHMYGU-ID
Caerdydd Ymchwilydd Arweiniol yr astudiaeth Asesu Effaith Genomig ar Niwrodatblygiad (IMAGINE-ID) (cydweithrediad â D. Skuse (Coleg Prifysgol Llundain)).
Ariennir y Cyngor Ymchwil Feddygol (MRC).
Tudalen we: https://imagine-id.org/
Rhwydwaith Genynnau i Iechyd Meddwl (G2MH)
Prif Ymchwilydd un o glwstwr o naw grant NIMH RO1 sy'n astudio proffiliau iechyd meddwl a niwrowybyddol unigolion â dileu neu ddyblygu 16p11.2 a 22q11.2 (cydweithrediad â R. Gur (Prifysgol Pennsylvania), gan gynnwys Prifysgolion California (yn Los Angeles a San Diego) ac Ysbyty Plant Philadelphia yn UDA, prifysgolion Toronto a Montreal yng Nghanada, Katholieke Universiteit Leuven yng Ngwlad Belg a Phrifysgol Maastricht yn yr Iseldiroedd.
Ariennir gan Sefydliad Cenedlaethol Iechyd Meddwl UDA (NIMH).
Gwefan: genes2mentalhealth.com
Biofarcwyr ar gyfer anabledd deallusol ac anhwylder sbectrwm awtistiaeth wrth ddileu a dyblygu 16p11.2
Pecyn Gwaith Ffenoteipio Arweinydd rhaglen ymchwil sy'n astudio llwybrau signalau mewn unigolion sydd â dileu neu ddyblygu 16p11.2 (cydweithrediad â R. Brambilla (Prifysgol Caerdydd)).
Wedi'i ariannu gan MRC.
Partneriaeth Trosglwyddo Gwybodaeth
Partneriaeth gyda'r elusen gymorth CEREBRA i wella iechyd meddwl i blant ag anableddau niwroddatblygiadol sy'n gysylltiedig â CNV.
Ariannwyd Innovate UK a CEREBRA.
Gwefan: https://cerebra.org.uk/what-we-do/research/our-research-partners/cardiff-university/
Profiad o chwarae rolau arweiniol mewn consortia rhyngwladol:
- Consortiwm Rhyngwladol Genynnau i Iechyd Meddwl (G2MH) (Arweinydd Safle)
- Multimobidity iechyd corfforol a meddyliol ar draws y cyfnod oes (Ymchwil aml-afiachusrwydd LIfespaN Cydweithredol (LINC))(Arwain)
- Pwyllgor Llywio Rhwydwaith Clefydau Genetig Prin NIMH (MHRGDN) Iechyd Meddwl (Aelod)
- 22q11.2 Syndrom Dileu Consortiwm Rhyngwladol yr Ymennydd ac Ymddygiad (IBBC) (Cydlynydd hanner safleoedd yr UE)
- Consortiwm MINDDS Pan-UE (Arweinydd Pecyn Gwaith)
Aelodaeth arall:
- Uned Ymchwil Arennau Cymru ym Mhrifysgol Caerdydd
- Prif gydweithiwr wedi'i eni yn Bradford Rhaglen Age of Wonder ym Mhrifysgol Leeds
- Partner Academaidd Cleft Collective Cohort ym Mhrifysgol Bryste
Cyllid diweddar dethol:
Sefydliad Waterloo, Datblygu Meddyliau. PI J. Hall. Fy rôl: Cyd-I: £1,250,512.
Gwobr Cynaliadwyedd Ymchwil Iechyd a Gofal Cymru. Uned Ymchwil Arennau Cymru. PI: D. Fraser. Fy rôl: Co-I, £2.984,527.
Ymddiriedolaeth Croesawu. Nodweddu heterogenedd clinigol ac etioleg cymeriant bwyd cyfyngol osgoi. PI: S. Chawner. Fy rôl: Co-I. £3,965,962
Ymddiriedolaeth Croesawu. Ffenoteipio microstrwythurol dwfn y meddwl sy'n datblygu (astudiaeth BEAM). PI: D. Jones. Fy rôl: Cyd-PI. £5,987,599
Ymddiriedolaeth Croesawu. The Sleep Detectives: Sleep stratification in young people at high risk of psychosis. PI: M. Jones. Fy rôl: Co-I. £932,252.
MRC. Effaith Amrywiadau Rhif Copi sy'n gysylltiedig â sgitsoffrenia ar ddeinameg rhwydwaith cortical (astudiaeth CONVERGE). PI: J. Hall. Fy rôl: Co-I. £2,449,454.
MRC, ESRC, NIHR. Aml-afiachusrwydd iechyd corfforol a meddwl ar draws rhychwant oes (ymchwil aml-morbidrwydd LIfespaN Cydweithredol: LINC). Fy rôl: PI. £3,631,451
MRC. Improving mental health outcomes in children born with orofacial cleft: Identifying children at most risk to target clinical provision. PI: E. Stergiakouli. Fy rôl: Co-I. £748,523
MRC, ESCR, NIHR. Ymchwilio i bum astudiaeth garfan fawr sy'n seiliedig ar boblogaeth i ddeall rhagflaenwyr risg aml-morbidity. Fy rôl: PI. £74,363.78
MRF. Y berthynas rhwng y locws 16p11.2 ac anhwylderau bwyta: mewnwelediadau newydd o gyflyrau genetig prin. PI: S. Chawner. Fy rôl: Co-I. £288,106.
MRC. IMAGINE-2: Stratifying Genomic Causes of Intellectual Disability by Mental Health Outcomes in Childhood and Adolescence. PI: D. Skuse. Fy rôl: Co-I, Arweinydd Pecyn Gwaith 2 (ffenoteipio wyneb yn wyneb). £1,999,599.26
Ymddiriedolaeth Croeso ISSF. Defnyddio genomeg i ddeall tarddiad datblygiadol cynnar cyflyrau seiciatrig. PI: S. Chawner. Rôl: Fy rôl: Noddwr ymchwil. £69,443.
NIMH. Atodiad i 7/9: Dadansoddi effeithiau amrywiadau genomig ar ddimensiynau niwroymddygiadol mewn CNVs wedi'u cyfoethogi ar gyfer anhwylderau niwroseiciatrig. Is-gontract i Ysbyty Plant Philadelphia (CHOP). Fy rôl: PI: $ 41,833.80
MRC. Targedu signalau ERK i wella anabledd deallusol ac anhwylder sbectrwm awtistiaeth sy'n gysylltiedig ag ad-drefniadau cromosomaidd yn 16p11.2. PI: R. Brambilla. Fy rôl Co-I, Arweinydd Pecyn Gwaith 1 (ffenoteipio wyneb yn wyneb). £1,181,767.
NIMH. RO1 (7) yw: 7/9 Dadansoddi effeithiau amrywiadau genomig ar ddimensiynau niwroymddygiadol mewn CNVs wedi'u cyfoethogi ar gyfer anhwylderau niwroseiciatrig. PI: R. Gur. Fy rôl: PI. $6,000,000 ($1,477,560 i Gaerdydd yn uniongyrchol).
Ymddiriedolaeth Elusennol Baily Thomas. Astudiaeth beilot i ddatblygu ac offeryn i ddal problemau niwroddatblygiadol eang mewn plant sydd â diagnosis genetig o anabledd deallusol. Fy rôl: PI. £48,502.
Takeda. Sefydlu set raddadwy o lwyfannau profion y gellir sgrinio canlyniadau ffenoteip trin y targedau unigryw a nodwyd yn eu herbyn ac effeithio'r cyfansoddion cyffuriau a aseswyd i ddatblygu therapiwteg ar gyfer sgitsoffrenia. PI: L. Wilkinson. Fy rôl: Co-I. £2,960,749.
Innovate UK, CEREBRA. Partneriaeth Trosglwyddo Gwybodaeth (KTP). Gwella iechyd meddwl i blant ag anableddau niwroddatblygiadol: Partneriaeth Trosglwyddo Gwybodaeth rhwng Cerebra a Phrifysgol Caerdydd. Fy rôl: PI. £216,320.
Cydweithrediad yr Undeb Ewropeaidd mewn Gwyddoniaeth a Thechnoleg (COST). Maximising Impact of research in Neuro-Developmental DisorderS (MINDDS). PI: A. Harwood. Fy rôl: Aelod o'r Pwyllgor Rheoli ac Arweinydd Gweithgor 2.
MRC. Anabledd deallusol ac iechyd meddwl: asesu effaith genomig ar niwrodatblygiad (astudiaeth IMAGINE). Pi: D. Skuse. Fy rôl: Cyd-PI. £3,127,715.
Addysgu
Mae profiadau addysgu yn cynnwys:
Epidemioleg a bioleg camddefnyddio sylweddau (myfyrwyr meddygol ym Mhrifysgol Caerdydd).
CNVs a risg iechyd meddwl (myfyrwyr PhD).
Rwyf wedi arwain y radd meddygol mewn Seicoleg a Meddygaeth ym Mhrifysgol Caerdydd
Bywgraffiad
Addysg:
- BSc Seicoleg, Vrije Universiteit, Yr Iseldiroedd
- MSc Seicoleg Arbrofol, Vrije Universiteit, Yr Iseldiroedd
- PhD, Geneteg Ddynol, Coleg Meddygol Virginia - Prifysgol Gymanwlad Virginia, Richmond, VA.
Dyfarniadau:
- Gwobr Effaith Gymdeithasol RCUK, Gwobrau Pen-blwydd KTP 40 (2015)
- Gwobr Arloesedd Cymdeithasol Prifysgol Caerdydd (2015)
- Derbyniodd prosiect ymchwil 'Gwella gwasanaethau iechyd meddwl i bobl ddigartref' y radd uchaf o "Eithriadol" gan Banel Graddio KTP am gyflawniad wrth gyflawni Amcanion KTP (2014)
- Gwobr Cyhoeddi'r Bwrdd Cynghori Ymchwil Ewropeaidd (2013)
Swyddi academaidd:
- Sefydliad Arweiniol Effaith Meddygaeth Seicolegol a Niwrowyddorau Clinigol
- Ysgol Meddygaeth Aelod Grŵp Rheoli REF
Meysydd goruchwyliaeth
Hyd yn hyn rwyf wedi llwyddo i oruchwylio 14 o fyfyrwyr PhD a chymrodyr clinigol.
Mae croeso i chi gysylltu â mi os ydych chi'n edrych i wneud PhD mewn grŵp ymchwil bywiog ac mae gennych ddiddordeb yn:
- Geneteg
- Iechyd Meddwl
- Gwybyddiaeth
- Syndromau genetig prin
- Aml-afiachus iechyd meddwl a chorfforol
- Epidemioleg
- Ymchwil hydredol
Goruchwyliaeth gyfredol
Ymgysylltu
Cyflwyniadau Nodyn Allweddol:
- Lectio Magistralis yng Ngŵyl Della Scienza, Genoa, Yr Eidal (2020).
- Darlith CEREBRA, Caerdydd (2019)
- Cynhadledd Grŵp Cynghori Meddygol Rhyngwladol (IMAG), Amsterdam (2014)
- Cynhadledd Flynyddol Seiciatreg Caethiwed 2012, Caerdydd (2012)
- Cynhadledd Grŵp Cynghori Meddygol Rhyngwladol (IMAG), Frascati, Yr Eidal (2010)
- Cyngres Ryng-Geltaidd, St Malo, Ffrainc (2007).
- Cyfarfod Blynyddol Coleg Brenhinol y Seiciatryddion, Glasgow, yr Alban (2006)
Detholiad o gyflwyniadau eraill:
- Cyngres 'Yr hyn rwy'n ei wybod orau', yn darlithio Genetegwyr Meddygol, Rhufain, yr Eidal (2020).
- Cleft Collective Cohort Studies, Bryste (2019)
- Aelod o'r Panel yn nigwyddiad dathlu 10 mlynedd Canolfan y Cyngor Ymchwil Feddygol ar gyfer Geneteg a Genomeg Niwroseiciatrig, Caerdydd (2019)
- Cyngres Seiciatreg y Gymdeithas Ewropeaidd ar gyfer Plant a'r Glasoed (ESCAP), Fienna, Awstria (2019)
- Symposiwm Sefydliad Waterloo, "Newid Meddyliau," Caerdydd (2019)
- Diwrnod teulu a chlinigwyr elusennol Gogledd Iwerddon, Belfast (2019)
- Cyfarfod clinigol y Ganolfan Meddygaeth Genomeg, Manceinion (2018).
- Diwrnod Ymchwil Anhwylderau Niwroddatblygiadol Canolfan NMHRI i ddathlu agoriad y Ganolfan Datblygu Plant newydd, Caerdydd (2018)
- Cyflwyniad i Llysgennad Gwlad Belg yn y DU, y Llysgennad Rudolf Huygelen, Caerdydd (2017)
- 16p11.2 diwrnod i'r teulu, Caerdydd (2016)
- Canolfan MRC ar gyfer Bwrdd Cynghori Allanol Geneteg a Genomeg Niwroseiciatrig, Caerdydd (2016)
- Medical Genetics Regional Genetics Genetics Centres, Llundain (2016).
- Cynhadledd Ryngwladol Coleg Brenhinol y Seiciatryddion, Llundain (2016)
- Y Ganolfan Genedlaethol ar gyfer Iechyd Meddwl (NCMH), Caerdydd (2016).
- 22q11.2 Cyfarfod teulu Syndrom Dileu. MaxAppeal! (2015)
- Coleg Ewropeaidd Niwroseicopharmacology (ECNP), Amsterdam (2015)
- Sefydliad Waterloo - Digwyddiad Anhwylderau a Therapïau Niwroddatblygiadol, Caerdydd (2015)
- Diweddariad Geneteg ar gyfer cyfarfod Paediatregwyr, Caerdydd (2014)
- 22q11.2 Cyfarfod teulu Syndrom Dileu. MaxAppeal!, Stourbridge (2015)
- Ysbyty Guys, Llundain (2014)
- Cyfarfod Grŵp Geneteg Glinigol De-orllewin Prydain, Caerdydd (2013)
- Pedwerydd Symposiwm Caerdydd ar Eneteg Cardiofasgwlaidd Clinigol "Tueddiadau Cyfredol mewn Diagnosis a Therapi Anhwylderau Cardiofasgwlaidd Etifeddol", Caerdydd (2013)
- Symposiwm y Brifysgol Agored ar Psychosis. Sesiwn Uchafbwyntiau Ymchwil y DU. Cyfres Gwyddorau Ymennydd ac Ymddygiad, Milton Keynes (2013)
- Grŵp Dymorffoleg De-ddwyrain (Cyfarfod Syndrom Kleefstra), Ysbyty Guy's, Llundain (2013).
Ymgysylltiad Eraill a ddewiswyd:
- Cyfraniad i'r llyfr plant "Fy mhrofiad: beth sydd gan iechyd meddwl i'w wneud â'r ymennydd?" i'r llyfr "Beth yw iechyd meddwl? O ble'r mae'n dod? A chwestiynau mawr eraill" gan Lucy Maddox, Wayland (2019) (https://www.worldbookday.com/2020/05/best-books-for-8-12-year-olds-for-mental-health-awareness-week/).
- Podlediad NCMH am 22q11.2DS (https://www.ncmh.info/videos-and-podcasts/podcast/episode-6-22q11-2-deletion-syndrome/
- Cyfweliad Clefyd Prin y Sefydliad Cenedlaethol ar gyfer Ymchwil Iechyd (NIHR): https://www.nihr.ac.uk/news-and-events/support-our-campaigns/rare-disease-day-2018/echo-study.htm
- BBC Cymru Radio (https://www.cardiff.ac.uk/news/view/1726668-sleep-problems-in-children-with-genetic-condition-linked-to-mental-health-issues,-clumsiness-and-impaired-planning-ability,-experts-say).
- Diwrnod Clefyd Prin (https://animoto.com/play/baR6a8NMV7Z6QiNbdlcrfg)
- Y Sgwrs (https://www.spectrumnews.org/news/deletion-duplication-chromosome-16-segment-may-confer-autism-risk/)
- Sioe frecwast y BBC: (https://www.bbc.co.uk/news/uk-wales-46292480)(http://www.cardiff.ac.uk/news/view/1371274-awareness-of-22q)
- Ffilmiau YouTube (https://www.youtube.com/watch?v=7k-Njq95yp0)
Contact Details
VANDENBREEMB@caerdydd.ac.uk
+44 29206 88433
Adeilad Hadyn Ellis, Ystafell 2.16, Heol Maendy, Caerdydd, CF24 4HQ
+44 29206 88433
Adeilad Hadyn Ellis, Ystafell 2.16, Heol Maendy, Caerdydd, CF24 4HQ
Themâu ymchwil
Arbenigeddau
- Geneteg Seiciatrig
- Aml-forbidrwydd
- ymchwil hydredol
