![John Watkins](https://profiles-cardiff.imgix.net/attachments/2635?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Trosolwyg
Rwy'n Uwch Ddarlithydd ac yn Ystadegydd Meddygol. Mae gen i ddiddordeb mawr yn y defnydd o fethodolegau ystadegol a methodolegau eraill i nodi a disgrifio materion iechyd a lles mewn plant o fabanod newydd i bobl ifanc yn eu harddegau ac ers 2008 dyma'r meysydd lle mae'r mwyafrif helaeth o'm hymchwil wedi'i gynnal.
Mae rhan fawr o fy ymchwil wedi bod fel rhan o grŵp sydd wedi ymchwilio i effeithiau cynaeddfedrwydd, pwysau geni isel a phwysau geni isel ar gyfer oedran beichiogrwydd ar ganlyniadau gan gynnwys gallu'r ysgyfaint yn ddiweddarach mewn bywyd, nifer yr achosion o gyflyrau anadlol fel asthma, gallu ymarfer corff a marwolaeth gyffredinol. Yn fwy diweddar mae'r gwaith hwn wedi cael ei ymestyn i edrych ar effeithiau llygredd adeg genedigaeth ac yna ar farwolaethau ac afiachedd diweddarach.
Mae un arall o fy meysydd ymchwil wedi ymwneud ag amddiffyn plant, o ran dulliau newydd o nodi cam-drin plant a sefyllfaoedd lle gallai plant gael eu hanafu'n ddamweiniol oherwydd diffyg gwerthfawrogiad rhieni o beryglon.
Mae ardal gymharol newydd wedi ymwneud ag ymchwilio i ddulliau methodolegol newydd o ailystyried rhai dogma hirsefydlog ynghylch asesu a thrin babanod newydd-anedig, yn benodol y rhai sy'n rhag-dymor iawn. Mae hyn yn cynnwys cynhyrchu siartiau twf rhagfynegol prototeip newydd ar gyfer cyn-dermau sy'n seiliedig ar ddata gwirioneddol cyn y tymor ac felly maent yn fwy cynrychioliadol na'r data cyfeirio presennol.
Cyhoeddiad
2024
- Course, C. W. et al. 2024. Similarities of metabolomic disturbances in prematurity-associated obstructive lung disease to chronic obstructive pulmonary disease. Scientific Reports 14(1), article number: 23294. (10.1038/s41598-024-73704-1)
- Gullick, G. et al. 2024. UK multicentre real-world data of the use of cyclin-dependent kinase 4/6 inhibitors in metastatic breast cancer. ESMO Real World Data and Digital Oncology 5, article number: 100064. (10.1016/j.esmorw.2024.100064)
- Bennett, V., Spasic, I., Filimonov, M., Muralidaran, V., Kemp, A. M., Allen, S. and Watkins, W. J. 2024. Assessing the feasibility of using parents' social media conversations to inform burn first aid interventions: mixed methods study. JMIR Formative Research 8, article number: e48695. (10.2196/48695)
- Watkins, W. J., Course, C. W., Cousins, M., Hart, K., Kotecha, S. J. and Kotecha, S. 2024. Impact of ambient air pollution on lung function in preterm-born school-aged children. Thorax 79(6), pp. 553-563. (10.1136/thorax-2023-220233)
- Yeo, D. C. M., Davies, R., Watkins, W. J. and Watts, P. 2024. The incidence, clinical features, and management of essential infantile esotropia in the United Kingdom. A British Ophthalmology Surveillance Unit (BOSU) study. Eye 38, pp. 680-686. (10.1038/s41433-023-02901-5)
- Nieto-Rosado, M. et al. 2024. Colonisation of hospital surfaces from low- and middle-income countries by extended spectrum β-lactamase- and carbapenemase-producing bacteria. Nature Communications 15, article number: 2758. (10.1038/s41467-024-46684-z)
- Webb, J. et al. 2024. A new formula for estimating insertion length of umbilical catheters in neonates: An observational study. Journal of Neonatology (10.1177/09732179241234515)
- Taylor, R. et al. 2024. Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studies. EBioMedicine 100, article number: 104981. (10.1016/j.ebiom.2024.104981)
- Kodosaki, E. et al. 2024. Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes. Journal of Neuroinflammation 21(1), article number: 52. (10.1186/s12974-024-03036-4)
2023
- Course, C. W. et al. 2023. Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia. Scientific Reports 13(1), article number: 19465. (10.1038/s41598-023-46499-w)
- Kotecha, E. et al. 2023. Association of early and current life factors with telomere length in preterm-born children. PLoS ONE 18(11), article number: e0293589. (10.1371/journal.pone.0293589)
- Wyllie, T., Folaranmi, E., Sekaran, P., Watkins, W. J. and Chakraborty, M. 2023. Prophylactic acid-suppression medication to prevent anastomotic strictures after oesophageal atresia surgery: a systematic review and meta-analysis. Journal of Pediatric Surgery 58(10), pp. 1954-1962. (10.1016/j.jpedsurg.2023.05.024)
- Cousins, M., Hart, K., Kotecha, S. J., Henderson, A. J., Watkins, W. J., Bush, A. and Kotecha, S. 2023. Characterising airway obstructive, dysanaptic and PRISm phenotypes of prematurity-associated lung disease. Thorax 78(9), pp. 895-903. (10.1136/thorax-2022-219301)
- Course, C. W. et al. 2023. Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia. Scientific Reports 13, article number: 7330. (10.1038/s41598-023-34233-5)
- Course, C. W., Kotecha, S. J., Cousins, M., Hart, K., Lowe, J., Watkins, W. J. and Kotecha, S. 2023. Association of gestation and fetal growth restriction on cardiovascular health in preterm-born children. Journal of Pediatrics 255, pp. 42-49. (10.1016/j.jpeds.2022.09.057)
- Parkinson, E. et al. 2023. Gene filtering strategies for machine learning guided biomarker discovery using neonatal sepsis RNA-seq data. Frontiers in Genetics 14, article number: 1158352. (10.3389/fgene.2023.1158352)
- Oruganti, S. et al. 2023. Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study. BMJ Open 13, article number: e067002. (10.1136/bmjopen-2022-067002)
- Chan, H. et al. 2023. Image phenotyping of preterm-born children using hyperpolarised 129Xe lung MRI and multiple-breath washout. American Journal of Respiratory and Critical Care Medicine 207(1), pp. 89-90. (10.1164/rccm.202203-0606OC)
- Farzana, R. et al. 2023. Genomic insights into the mechanism of carbapenem resistance dissemination in Enterobacterales from a tertiary public heath setting in South Asia. Clinical Infectious Diseases 76(1), pp. 119-133. (10.1093/cid/ciac287)
2022
- Kotecha, S. J., Gibbons, J. T. D., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Geographical differences and temporal improvements in forced expiratory volume in 1 second of preterm-born children. JAMA Pediatrics 176(9), pp. 867-877. (10.1001/jamapediatrics.2022.1990)
- Carvalho, M. J. et al. 2022. Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries. Nature Microbiology 7, pp. 1337-1347. (10.1038/s41564-022-01184-y)
- Kotecha, S. J., Course, C. W., Jones, K. E., Watkins, W. J., Berrington, J., Gillespie, D. and Kotecha, S. 2022. Follow-up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants: study protocol for the AZTEC-FU study. Trials 23, article number: 796. (10.1186/s13063-022-06730-x)
- Sharma, S. et al. 2022. mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health – a prospective observational cohort study protocol. BMJ Open 12(9), article number: e066382. (10.1136/bmjopen-2022-066382)
- Kotecha, S., Cousins, M., Hart, K., Watkins, W. J. and Kotecha, S. 2022. Effect of IUGR and catch-up growth on later lung function in preterm children: prospective cohort study. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1186., (10.1183/13993003.congress-2022.1186)
- Kotecha, E. et al. 2022. Telomere length in preterm-born children with bronchopulmonary dysplasia (BPD). Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1292., (10.1183/13993003.congress-2022.1292)
- Kotecha, S., Hart, K., Cousins, M., Watkins, W. J., Henderson, A. J. and Kotecha, S. 2022. Association of early life factors with prematurity-associated lung disease : prospective cohort study. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1183., (10.1183/13993003.congress-2022.1183)
- Kotecha, S., Gibbons, J., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Systematic review and meta-analysis of FEV1 in preterm born children. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1172., (10.1183/13993003.congress-2022.1172)
- Sands, K. et al. 2022. Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries. BMC Infectious Diseases 22(1), article number: 593. (10.1186/s12879-022-07541-w)
- Milton, R. et al. 2022. Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: an international multisite prospective observational study. The Lancet Global Health 10(5), pp. e661-e672. (10.1016/S2214-109X(22)00043-2)
- Hart, K., Cousins, M., Watkins, W. J., Kotecha, S. J., Henderson, A. J. and Kotecha, S. 2022. Association of early life factors with prematurity-associated lung disease: prospective cohort study. European Respiratory Journal 59(5), article number: 2101766. (10.1183/13993003.01766-2021)
- Asderakis, A. et al. 2022. Thymoglobulin versus alemtuzumab versus basiliximab kidney transplantation from donors after circulatory death. Kidney International Reports 7(4), pp. 732-740. (10.1016/j.ekir.2022.01.1042)
- Milton, R. et al. 2022. Determinants of stillbirth from two observational studies investigating deliveries in Kano, Nigeria. Frontiers in Global Women's Health 2, article number: 788157. (10.3389/fgwh.2021.788157)
- Stuttaford, L., Webb, J., Smith, S. L., Powell, C., Watkins, W. J. and Chakraborty, M. 2022. Estimating insertion length of umbilical arterial and venous catheters in newborn infants: time for change. Journal of Maternal-Fetal and Neonatal Medicine 35(19), pp. 3770-3775. (10.1080/14767058.2020.1838478)
2021
- Chakraborty, M. et al. 2021. nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study. BMJ Open 11(12), article number: e050100. (10.1136/bmjopen-2021-050100)
- Hassan, B. et al. 2021. A role for arthropods as vectors of multidrug-resistant Enterobacterales in surgical site infections from South Asia. Nature Microbiology 6(10), pp. 1270. (10.1038/s41564-021-00965-1)
- Newbury, L. J. et al. 2021. miR-141 mediates recovery from acute kidney injury. Scientific Reports 11(1), article number: 16499. (10.1038/s41598-021-94984-x)
- Hussain, R. N., Rad, D., Watkins, W. J. and Carpenter, C. 2021. The incidence of avascular necrosis following a cohort of treated developmental dysplasia of the hip in a single tertiary centre. Journal of Children's Orthopaedics 15(3), pp. 232-240. (10.1302/1863-2548.15.200246)
- Bailey, H. D., Kotecha, S. J., Watkins, W. J., Adane, A. A., Shepherd, C. C. J. and Kotecha, S. 2021. Comparison of stillbirth trends over two decades in Wales and Western Australia using pooled routinely collected health data: international retrospective cohort study. Paediatric and Perinatal Epidemiology 35(3), pp. 302-314. (10.1111/ppe.12739)
- Course, C., Watkins, W. J., Müller, C. T., Odd, D., Kotecha, S. and Chakraborty, M. 2021. Volatile organic compounds as disease predictors in newborn infants: a systematic review. Journal of Breath Research 15(2), article number: 24002. (10.1088/1752-7163/abe283)
- Manivannan, S. et al. 2021. Management of neurotrauma during COVID-19: a single centre experience and lessons for the future. Brain Injury 35(8), pp. 957-963. (10.1080/02699052.2021.1934731)
2020
- Pires, A. et al. 2020. Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunology Research 8(12), pp. 1520 - 1531. (10.1158/2326-6066.CIR-20-0070)
- Kotecha, S. . J., Watkins, W. J., Lowe, J., Grigg, J. and Kotecha, S. 2020. Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study. PLoS Medicine 17(10), article number: e1003400. (10.1371/journal.pmed.1003400)
- Chakraborty, M., Watkins, W. J., Tansey, K., King, W. E. and Banerjee, S. 2020. Predicting extubation outcomes using Heart Rate Characteristics index in preterm infants: a cohort study. European Respiratory Journal 56(4), article number: 1901755. (10.1183/13993003.01755-2019)
- Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13(3), pp. 149-164., article number: e002806. (10.1161/CIRCGEN.119.002806)
- Kotecha, S. J., Lowe, J., Granell, R., Watkins, W. J., Henderson, A. J. and Kotecha, S. 2020. The effect of catch-up growth in the first year of life on later wheezing phenotypes. European Respiratory Journal 55(6), article number: 2000884. (10.1183/13993003.00884-2020)
- Watkins, W. J., Farewell, D., Banerjee, S., Nasef, H., James, A. and Chakraborty, M. 2020. Modelling predictive gender- and gestation-specific weight reference centiles for preterm infants using a population-based cohort study. Scientific Reports 10, article number: 4302. (10.1038/s41598-020-60895-6)
2019
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Farzana, R. et al. 2019. Outbreak of hypervirulent multi-drug resistant Klebsiella variicola causing high mortality in neonates in Bangladesh. Clinical Infectious Diseases 7, pp. 1225-1227. (10.1093/cid/ciy778)
- Kotecha, S. J., Watkins, W. J., Lowe, J., Granell, R., Henderson, A. . and Kotecha, S. 2019. Comparison of the associations of early-life factors on wheezing phenotypes in preterm-born children and term-born children. American Journal of Epidemiology 188(3), pp. 527-536. (10.1093/aje/kwy268)
- Dantoft, W., Robertson, K. A., Watkins, W. J., Strobl, B. and Ghazal, P. 2019. Metabolic regulators Nampt and Sirt6 serially participate in the macrophage interferon antiviral cascade. Frontiers in Microbiology (10.3389/fmicb.2019.00355)
2018
- Kotecha, S., Watkins, W. J., Lowe, J., Granell, R., Henderson, A. J. and Kotecha, S. 2018. Association of early life factors with wheezing phenotypes in preterm-born children compared to term-born children. European Respiratory Journal 52(Sup. 6), article number: OA3306. (10.1183/13993003.congress-2018.OA3306)
- Janssen, A. et al. 2018. Persistence of anxiety symptoms after elective caesarean delivery. Bjpsych Open 4(5), pp. 354-360. (10.1192/bjo.2018.48)
- Naughton, A., Nurmatov, U., Hoytema van Konijnenburg, E., Watkins, W. J., Otterman, G., Nelson, J. and Kemp, A. 2018. Variability in child protection medical evaluations of suspected physical abuse in four European countries: a vignette study. Child Abuse Review 27(5), pp. 404-418. (10.1002/car.2515)
- Akbari, A. et al. 2018. Evaluating the implementation of the Inverse Care Law Programme in Wales, a population based intervention in primary care. International Journal of Population Data Science 3(4), article number: 184. (10.23889/ijpds.v3i4.777)
- Song, J. et al. 2018. The Inverse Care Law programme: evaluating a population based intervention in primary care within deprived communities in Wales.. International Journal of Population Data Science 3(2), article number: 52. (10.23889/ijpds.v3i2.521)
- Goel, N., Chakraborty, M., Watkins, W. J. and Banerjee, S. 2018. Predicting extubation outcomes - a model incorporating heart rate characteristics index. Journal of Pediatrics 195, pp. 53-58., article number: e1. (10.1016/j.jpeds.2017.11.037)
- Lowe, J., Kotecha, S., Watkins, W. and Kotecha, S. 2018. Effect of fetal and infant growth on respiratory symptoms in preterm-born children. Pediatric Pulmonology 53(2), pp. 189-196. (10.1002/ppul.23920)
2017
- Hibberd, O., Nuttall, D., Watson, R. E., Watkins, W. J., Kemp, A. M. and Maguire, S. 2017. Childhood bruising distribution observed from eight mechanisms of unintentional injury. Archives of Disease in Childhood 102(12), pp. 1103-1109. (10.1136/archdischild-2017-312847)
- Davies, R., Watkins, W. J., Kotecha, S. and Watts, P. 2017. The presentation, clinical features, complications, and treatment of congenital dacryocystocele. Eye 32, pp. 522-526. (10.1038/eye.2017.235)
2016
- Kotecha, S., Watkins, W. J., Lowe, J., Henderson, A. J. and Kotecha, S. 2016. Effect of early-term birth on respiratory symptoms and lung function in childhood and adolescence. Pediatric Pulmonology 51(11), pp. 1212-1221. (10.1002/ppul.23448)
- Poon, C. Y. et al. 2016. Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity. Archives of Disease in Childhood-Fetal and Neonatal Edition 101(4), pp. F309-F313. (10.1136/archdischild-2015-309015)
- Edwards, M., Kotecha, S. J., Lowe, J., Richards, L., Watkins, W. J. and Kotecha, S. 2016. Management of prematurity-associated wheeze and its association with atopy. PLoS ONE 11(5), article number: e0155695. (10.1371/journal.pone.0155695)
- Lowe, J., Watkins, W. J., Kotecha, S. J. and Kotecha, S. 2016. Physical activity and sedentary behavior in preterm-born 7-year old children. PLoS ONE 11(5), article number: e0155229. (10.1371/journal.pone.0155229)
- Watkins, W. J., Kotecha, S. and Kotecha, S. 2016. All-cause mortality of low birthweight infants in infancy, childhood, and adolescence: population study of England and Wales. PLOS MEDICINE 13(5), article number: e1002018. (10.1371/journal.pmed.1002018)
2015
- Kotecha, S. J., Adappa, R., Gupta, N., Watkins, W. J., Kotecha, S. and Chakraborty, M. 2015. Safety and efficacy of high-flow nasal cannula therapy in preterm infants: a meta-analysis. Pediatrics 136(3), pp. 542-555. (10.1542/peds.2015-0738)
- Edwards, M. O., Kotecha, S. J., Lowe, J., Richards, L., Watkins, W. J. and Kotecha, S. 2015. Early-term birth is a risk factor for wheezing in childhood: a cross-sectional population study. Journal of Allergy and Clinical Immunology 136(3), pp. 581-587.e2. (10.1016/j.jaci.2015.05.005)
- Watts, P., Jewsbury, H., Okeya, M., Watkins, W. J. and Kotecha, S. 2015. Visual acuity and associations in children with high hypermetropia. Journal of AAPOS 19(4), pp. e67-e68. (10.1016/j.jaapos.2015.07.218)
- Kotecha, S. J., Watkins, W. J., Henderson, A. J. and Kotecha, S. 2015. The effect of birth weight on lung spirometry in white, school-aged children and adolescents born at term: a longitudinal population based observational cohort study. The Journal of Pediatrics 166(5), pp. 1163-1167. (10.1016/j.jpeds.2015.01.002)
- Lowe, J., Watkins, W., Kotecha, S., Edwards, M., Henderson, A. J. and Kotecha, S. 2015. Physical activity in school-age children born preterm. The Journal of Pediatrics 166(4), pp. 877-883. (10.1016/j.jpeds.2014.12.013)
- Edwards, M., Kotecha, S. J., Lowe, J., Watkins, W., Henderson, A. J. and Kotecha, S. 2015. Effect of preterm birth on exercise capacity: a systematic review and meta-analysis. Pediatric Pulmonology 50(3), pp. 293-301. (10.1002/ppul.23117)
- Kotecha, S., Edwards, M., Watkins, W., Lowe, J., Henderson, A. J. and Kotecha, S. 2015. Effect of bronchodilators on forced expiratory volume in 1 s in preterm-born participants aged 5 and over: a sytematic review. Neonatology 107(3), pp. 231-240. (10.1159/000371539)
2014
- Paranjothy, S., Watkins, W. J., Rolfe, K., Adappa, R., Gong, Y., Dunstan, F. D. J. and Kotecha, S. 2014. Perinatal outcomes and travel time from home to hospital: Welsh data 1995 to 2009. Acta Paediatrica 103(12), pp. e522-e527. (10.1111/apa.12800)
- Edwards, M., Watkins, W., Kotecha, S., Halcox, J. P., Dunstan, F., Henderson, A. J. and Kotecha, S. 2014. Higher systolic blood pressure with normal vascular function measurements in preterm-born children. Acta Paediatrica 103(9), pp. 904-912. (10.1111/apa.12699)
- Lowe, J., Watkins, W., Edwards, M., Spiller, O., Jacqz-Aigrain, E., Kotecha, S. and Kotecha, S. 2014. Association between pulmonary Ureaplasma colonization and bronchopulmonary dysplasia in preterm infants: updated systematic review and meta-analysis. The Pediatric Infectious Disease Journal 33(7), pp. 697-702. (10.1097/INF.0000000000000239)
- Pickerd, N., Williams, E. M., Watkins, W. and Kotecha, S. 2014. Tidal breathing in preterm infants receiving and weaning from continuous positive airway pressure. The Journal of Pediatrics 164(5), pp. 1058-1063.e1. (10.1016/j.jpeds.2013.12.049)
- Whyte, L., Kotecha, S., Watkins, W. and Jenkins, H. 2014. Coeliac disease is more common in children with high socio-economic status. Acta Paediatrica 103(3), pp. 289-294. (10.1111/apa.12494)
- Graham, E. A. M. et al. 2014. Defining background DNA levels found on the skin of children aged 0-5 years. International Journal of Legal Medicine 128(2), pp. 251-258. (10.1007/s00414-013-0906-8)
2013
- Paranjothy, S., Dunstan, F. D. J., Watkins, W. J., Hyatt, M., Demmler, J. C., Lyons, R. A. and Fone, D. L. 2013. Gestational age, birth weight, and risk of respiratory hospital admission in childhood. Pediatrics 132(6), pp. e1562-e1569. (10.1542/peds.2013-1737)
- Davies, M., Maguire, S. A., Okolie, C., Watkins, W. J. and Kemp, A. M. 2013. How much do parents know about first aid for burns?. Burns 39(6), pp. 1083-1090. (10.1016/j.burns.2012.12.015)
- Kotecha, S. J., Edwards, M. O., Watkins, W. J., Henderson, A. J., Paranjothy, S., Dunstan, F. D. J. and Kotecha, S. 2013. Effect of preterm birth on later FEV1: a systematic review and meta-analysis. Thorax 68(8), pp. 760-766. (10.1136/thoraxjnl-2012-203079)
- Paranjothy, S., Watkins, W., Rolfe, K., Gong, Y., Adappa, R., Dunstan, F. D. J. and Kotecha, S. 2013. Perinatal outcomes and travel time to maternity services: analysis of birth outcome data in Wales from 1995 to 2009. Archives of Disease in Childhood. Fetal and neonatal edition 98(Suppl), pp. A94. (10.1136/archdischild-2013-303966.323)
2012
- Maguire, S. A. et al. 2012. Retinal haemorrhages and related findings in abusive and non-abusive head trauma: a systematic review. Eye 27, pp. 28-36. (10.1038/eye.2012.213)
- Joshi, S., Powell, T., Watkins, W. J., Drayton, M., Williams, E. M. and Kotecha, S. 2012. Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy. The Journal of Pediatrics 162(4), pp. 813-818. (10.1016/j.jpeds.2012.09.040)
- Lyons, R. A. et al. 2012. Development and use of a privacy-protecting total population record linkage system to support observational, interventional, and policy relevant research. The Lancet 380, article number: S6. (10.1016/S0140-6736(13)60362-1)
2011
- Kotecha, S. J., Watkins, W. J., Paranjothy, S., Dunstan, F. D. J., Henderson, A. J. and Kotecha, S. 2011. Effect of late preterm birth on longitudinal lung spirometry in school age children and adolescents. Thorax 67(1), pp. 54-61. (10.1136/thoraxjnl-2011-200329)
- Watkins, W. J., Roberts, Z. E. S., Dunstan, F. D. J., King, W. and Fone, D. L. 2011. An investigation through microsimulation of the inequities in Coronary Heart Disease (CHD) mortality and morbidity in Wales [Abstract]. Journal of Epidemiology and Community Health 65(S2), pp. A11-A12. (10.1136/jech.2011.143586.25)
2010
- Kotecha, S., Watkins, W. J., Heron, J., Henderson, J., Dunstan, F. D. J. and Kotecha, S. J. 2010. An analysis of the effect of intrauterine growth retardation on spirometric lung function measures of 8-year-old children [Abstract]. Journal of Epidemiology & Community Health 64(Supp 1), pp. A24. (10.1136/jech.2010.120956.60)
- Kotecha, S. J., Watkins, W. J., Heron, J., Henderson, J., Dunstan, F. D. J. and Kotecha, S. 2010. Spirometric lung function in school-age children: Effect of intrauterine growth retardation and catch-up growth. American Journal of Respiratory and Critical Care Medicine 181(9), pp. 969-974. (10.1164/rccm.200906-0897OC)
1999
- Watkins, W., Kennedy, D. and Williams, F. 1999. Efficient parallel solution of structural eigenvalue problems. Advances in Engineering Software 25(2-3), pp. 281-289. (10.1016/0965-9978(95)00094-1)
1997
- Watkins, W. J., Kennedy, D. and Williams, F. W. 1997. On estimating machine dependency of fine- and coarse-grained parallel structural computations. Computer-Aided Civil and Infrastructure Engineering 12(2), pp. 119-128. (10.1111/0885-9507.00050)
- Watkins, W. J., Kennedy, D. and Williams, F. 1997. Efficient parallel Gauss-Doolittle matrix triangulation. Computers and Structures 62(1), pp. 185-195. (10.1016/S0045-7949(96)00282-9)
1996
- Nicholson, D. et al. 1996. Results of the first coincident observations by two laser-interferometric gravitational wave detectors. Physics letters. A. 218(3-6), pp. 175-180. (10.1016/0375-9601(96)00438-0)
1995
- Kennedy, D., Watkins, W. J. and Williams, F. W. 1995. Hybrid parallel computation of transcendental structural eigenvalues. AIAA Journal 33(11) (10.2514/3.12966)
Articles
- Course, C. W. et al. 2024. Similarities of metabolomic disturbances in prematurity-associated obstructive lung disease to chronic obstructive pulmonary disease. Scientific Reports 14(1), article number: 23294. (10.1038/s41598-024-73704-1)
- Gullick, G. et al. 2024. UK multicentre real-world data of the use of cyclin-dependent kinase 4/6 inhibitors in metastatic breast cancer. ESMO Real World Data and Digital Oncology 5, article number: 100064. (10.1016/j.esmorw.2024.100064)
- Bennett, V., Spasic, I., Filimonov, M., Muralidaran, V., Kemp, A. M., Allen, S. and Watkins, W. J. 2024. Assessing the feasibility of using parents' social media conversations to inform burn first aid interventions: mixed methods study. JMIR Formative Research 8, article number: e48695. (10.2196/48695)
- Watkins, W. J., Course, C. W., Cousins, M., Hart, K., Kotecha, S. J. and Kotecha, S. 2024. Impact of ambient air pollution on lung function in preterm-born school-aged children. Thorax 79(6), pp. 553-563. (10.1136/thorax-2023-220233)
- Yeo, D. C. M., Davies, R., Watkins, W. J. and Watts, P. 2024. The incidence, clinical features, and management of essential infantile esotropia in the United Kingdom. A British Ophthalmology Surveillance Unit (BOSU) study. Eye 38, pp. 680-686. (10.1038/s41433-023-02901-5)
- Nieto-Rosado, M. et al. 2024. Colonisation of hospital surfaces from low- and middle-income countries by extended spectrum β-lactamase- and carbapenemase-producing bacteria. Nature Communications 15, article number: 2758. (10.1038/s41467-024-46684-z)
- Webb, J. et al. 2024. A new formula for estimating insertion length of umbilical catheters in neonates: An observational study. Journal of Neonatology (10.1177/09732179241234515)
- Taylor, R. et al. 2024. Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studies. EBioMedicine 100, article number: 104981. (10.1016/j.ebiom.2024.104981)
- Kodosaki, E. et al. 2024. Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes. Journal of Neuroinflammation 21(1), article number: 52. (10.1186/s12974-024-03036-4)
- Course, C. W. et al. 2023. Evidence of abnormality in glutathione metabolism in the airways of preterm born children with a history of bronchopulmonary dysplasia. Scientific Reports 13(1), article number: 19465. (10.1038/s41598-023-46499-w)
- Kotecha, E. et al. 2023. Association of early and current life factors with telomere length in preterm-born children. PLoS ONE 18(11), article number: e0293589. (10.1371/journal.pone.0293589)
- Wyllie, T., Folaranmi, E., Sekaran, P., Watkins, W. J. and Chakraborty, M. 2023. Prophylactic acid-suppression medication to prevent anastomotic strictures after oesophageal atresia surgery: a systematic review and meta-analysis. Journal of Pediatric Surgery 58(10), pp. 1954-1962. (10.1016/j.jpedsurg.2023.05.024)
- Cousins, M., Hart, K., Kotecha, S. J., Henderson, A. J., Watkins, W. J., Bush, A. and Kotecha, S. 2023. Characterising airway obstructive, dysanaptic and PRISm phenotypes of prematurity-associated lung disease. Thorax 78(9), pp. 895-903. (10.1136/thorax-2022-219301)
- Course, C. W. et al. 2023. Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia. Scientific Reports 13, article number: 7330. (10.1038/s41598-023-34233-5)
- Course, C. W., Kotecha, S. J., Cousins, M., Hart, K., Lowe, J., Watkins, W. J. and Kotecha, S. 2023. Association of gestation and fetal growth restriction on cardiovascular health in preterm-born children. Journal of Pediatrics 255, pp. 42-49. (10.1016/j.jpeds.2022.09.057)
- Parkinson, E. et al. 2023. Gene filtering strategies for machine learning guided biomarker discovery using neonatal sepsis RNA-seq data. Frontiers in Genetics 14, article number: 1158352. (10.3389/fgene.2023.1158352)
- Oruganti, S. et al. 2023. Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study. BMJ Open 13, article number: e067002. (10.1136/bmjopen-2022-067002)
- Chan, H. et al. 2023. Image phenotyping of preterm-born children using hyperpolarised 129Xe lung MRI and multiple-breath washout. American Journal of Respiratory and Critical Care Medicine 207(1), pp. 89-90. (10.1164/rccm.202203-0606OC)
- Farzana, R. et al. 2023. Genomic insights into the mechanism of carbapenem resistance dissemination in Enterobacterales from a tertiary public heath setting in South Asia. Clinical Infectious Diseases 76(1), pp. 119-133. (10.1093/cid/ciac287)
- Kotecha, S. J., Gibbons, J. T. D., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Geographical differences and temporal improvements in forced expiratory volume in 1 second of preterm-born children. JAMA Pediatrics 176(9), pp. 867-877. (10.1001/jamapediatrics.2022.1990)
- Carvalho, M. J. et al. 2022. Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low- and middle-income countries. Nature Microbiology 7, pp. 1337-1347. (10.1038/s41564-022-01184-y)
- Kotecha, S. J., Course, C. W., Jones, K. E., Watkins, W. J., Berrington, J., Gillespie, D. and Kotecha, S. 2022. Follow-up study of infants recruited to the randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants: study protocol for the AZTEC-FU study. Trials 23, article number: 796. (10.1186/s13063-022-06730-x)
- Sharma, S. et al. 2022. mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health – a prospective observational cohort study protocol. BMJ Open 12(9), article number: e066382. (10.1136/bmjopen-2022-066382)
- Sands, K. et al. 2022. Characterisation of Staphylococci species from neonatal blood cultures in low- and middle-income countries. BMC Infectious Diseases 22(1), article number: 593. (10.1186/s12879-022-07541-w)
- Milton, R. et al. 2022. Neonatal sepsis and mortality in low-income and middle-income countries from a facility-based birth cohort: an international multisite prospective observational study. The Lancet Global Health 10(5), pp. e661-e672. (10.1016/S2214-109X(22)00043-2)
- Hart, K., Cousins, M., Watkins, W. J., Kotecha, S. J., Henderson, A. J. and Kotecha, S. 2022. Association of early life factors with prematurity-associated lung disease: prospective cohort study. European Respiratory Journal 59(5), article number: 2101766. (10.1183/13993003.01766-2021)
- Asderakis, A. et al. 2022. Thymoglobulin versus alemtuzumab versus basiliximab kidney transplantation from donors after circulatory death. Kidney International Reports 7(4), pp. 732-740. (10.1016/j.ekir.2022.01.1042)
- Milton, R. et al. 2022. Determinants of stillbirth from two observational studies investigating deliveries in Kano, Nigeria. Frontiers in Global Women's Health 2, article number: 788157. (10.3389/fgwh.2021.788157)
- Stuttaford, L., Webb, J., Smith, S. L., Powell, C., Watkins, W. J. and Chakraborty, M. 2022. Estimating insertion length of umbilical arterial and venous catheters in newborn infants: time for change. Journal of Maternal-Fetal and Neonatal Medicine 35(19), pp. 3770-3775. (10.1080/14767058.2020.1838478)
- Chakraborty, M. et al. 2021. nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study. BMJ Open 11(12), article number: e050100. (10.1136/bmjopen-2021-050100)
- Hassan, B. et al. 2021. A role for arthropods as vectors of multidrug-resistant Enterobacterales in surgical site infections from South Asia. Nature Microbiology 6(10), pp. 1270. (10.1038/s41564-021-00965-1)
- Newbury, L. J. et al. 2021. miR-141 mediates recovery from acute kidney injury. Scientific Reports 11(1), article number: 16499. (10.1038/s41598-021-94984-x)
- Hussain, R. N., Rad, D., Watkins, W. J. and Carpenter, C. 2021. The incidence of avascular necrosis following a cohort of treated developmental dysplasia of the hip in a single tertiary centre. Journal of Children's Orthopaedics 15(3), pp. 232-240. (10.1302/1863-2548.15.200246)
- Bailey, H. D., Kotecha, S. J., Watkins, W. J., Adane, A. A., Shepherd, C. C. J. and Kotecha, S. 2021. Comparison of stillbirth trends over two decades in Wales and Western Australia using pooled routinely collected health data: international retrospective cohort study. Paediatric and Perinatal Epidemiology 35(3), pp. 302-314. (10.1111/ppe.12739)
- Course, C., Watkins, W. J., Müller, C. T., Odd, D., Kotecha, S. and Chakraborty, M. 2021. Volatile organic compounds as disease predictors in newborn infants: a systematic review. Journal of Breath Research 15(2), article number: 24002. (10.1088/1752-7163/abe283)
- Manivannan, S. et al. 2021. Management of neurotrauma during COVID-19: a single centre experience and lessons for the future. Brain Injury 35(8), pp. 957-963. (10.1080/02699052.2021.1934731)
- Pires, A. et al. 2020. Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunology Research 8(12), pp. 1520 - 1531. (10.1158/2326-6066.CIR-20-0070)
- Kotecha, S. . J., Watkins, W. J., Lowe, J., Grigg, J. and Kotecha, S. 2020. Differential association of air pollution exposure with neonatal and postneonatal mortality in England and Wales: A cohort study. PLoS Medicine 17(10), article number: e1003400. (10.1371/journal.pmed.1003400)
- Chakraborty, M., Watkins, W. J., Tansey, K., King, W. E. and Banerjee, S. 2020. Predicting extubation outcomes using Heart Rate Characteristics index in preterm infants: a cohort study. European Respiratory Journal 56(4), article number: 1901755. (10.1183/13993003.01755-2019)
- Meckelmann, S. W. et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13(3), pp. 149-164., article number: e002806. (10.1161/CIRCGEN.119.002806)
- Kotecha, S. J., Lowe, J., Granell, R., Watkins, W. J., Henderson, A. J. and Kotecha, S. 2020. The effect of catch-up growth in the first year of life on later wheezing phenotypes. European Respiratory Journal 55(6), article number: 2000884. (10.1183/13993003.00884-2020)
- Watkins, W. J., Farewell, D., Banerjee, S., Nasef, H., James, A. and Chakraborty, M. 2020. Modelling predictive gender- and gestation-specific weight reference centiles for preterm infants using a population-based cohort study. Scientific Reports 10, article number: 4302. (10.1038/s41598-020-60895-6)
- Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Farzana, R. et al. 2019. Outbreak of hypervirulent multi-drug resistant Klebsiella variicola causing high mortality in neonates in Bangladesh. Clinical Infectious Diseases 7, pp. 1225-1227. (10.1093/cid/ciy778)
- Kotecha, S. J., Watkins, W. J., Lowe, J., Granell, R., Henderson, A. . and Kotecha, S. 2019. Comparison of the associations of early-life factors on wheezing phenotypes in preterm-born children and term-born children. American Journal of Epidemiology 188(3), pp. 527-536. (10.1093/aje/kwy268)
- Dantoft, W., Robertson, K. A., Watkins, W. J., Strobl, B. and Ghazal, P. 2019. Metabolic regulators Nampt and Sirt6 serially participate in the macrophage interferon antiviral cascade. Frontiers in Microbiology (10.3389/fmicb.2019.00355)
- Kotecha, S., Watkins, W. J., Lowe, J., Granell, R., Henderson, A. J. and Kotecha, S. 2018. Association of early life factors with wheezing phenotypes in preterm-born children compared to term-born children. European Respiratory Journal 52(Sup. 6), article number: OA3306. (10.1183/13993003.congress-2018.OA3306)
- Janssen, A. et al. 2018. Persistence of anxiety symptoms after elective caesarean delivery. Bjpsych Open 4(5), pp. 354-360. (10.1192/bjo.2018.48)
- Naughton, A., Nurmatov, U., Hoytema van Konijnenburg, E., Watkins, W. J., Otterman, G., Nelson, J. and Kemp, A. 2018. Variability in child protection medical evaluations of suspected physical abuse in four European countries: a vignette study. Child Abuse Review 27(5), pp. 404-418. (10.1002/car.2515)
- Akbari, A. et al. 2018. Evaluating the implementation of the Inverse Care Law Programme in Wales, a population based intervention in primary care. International Journal of Population Data Science 3(4), article number: 184. (10.23889/ijpds.v3i4.777)
- Song, J. et al. 2018. The Inverse Care Law programme: evaluating a population based intervention in primary care within deprived communities in Wales.. International Journal of Population Data Science 3(2), article number: 52. (10.23889/ijpds.v3i2.521)
- Goel, N., Chakraborty, M., Watkins, W. J. and Banerjee, S. 2018. Predicting extubation outcomes - a model incorporating heart rate characteristics index. Journal of Pediatrics 195, pp. 53-58., article number: e1. (10.1016/j.jpeds.2017.11.037)
- Lowe, J., Kotecha, S., Watkins, W. and Kotecha, S. 2018. Effect of fetal and infant growth on respiratory symptoms in preterm-born children. Pediatric Pulmonology 53(2), pp. 189-196. (10.1002/ppul.23920)
- Hibberd, O., Nuttall, D., Watson, R. E., Watkins, W. J., Kemp, A. M. and Maguire, S. 2017. Childhood bruising distribution observed from eight mechanisms of unintentional injury. Archives of Disease in Childhood 102(12), pp. 1103-1109. (10.1136/archdischild-2017-312847)
- Davies, R., Watkins, W. J., Kotecha, S. and Watts, P. 2017. The presentation, clinical features, complications, and treatment of congenital dacryocystocele. Eye 32, pp. 522-526. (10.1038/eye.2017.235)
- Kotecha, S., Watkins, W. J., Lowe, J., Henderson, A. J. and Kotecha, S. 2016. Effect of early-term birth on respiratory symptoms and lung function in childhood and adolescence. Pediatric Pulmonology 51(11), pp. 1212-1221. (10.1002/ppul.23448)
- Poon, C. Y. et al. 2016. Pulmonary arterial response to hypoxia in survivors of chronic lung disease of prematurity. Archives of Disease in Childhood-Fetal and Neonatal Edition 101(4), pp. F309-F313. (10.1136/archdischild-2015-309015)
- Edwards, M., Kotecha, S. J., Lowe, J., Richards, L., Watkins, W. J. and Kotecha, S. 2016. Management of prematurity-associated wheeze and its association with atopy. PLoS ONE 11(5), article number: e0155695. (10.1371/journal.pone.0155695)
- Lowe, J., Watkins, W. J., Kotecha, S. J. and Kotecha, S. 2016. Physical activity and sedentary behavior in preterm-born 7-year old children. PLoS ONE 11(5), article number: e0155229. (10.1371/journal.pone.0155229)
- Watkins, W. J., Kotecha, S. and Kotecha, S. 2016. All-cause mortality of low birthweight infants in infancy, childhood, and adolescence: population study of England and Wales. PLOS MEDICINE 13(5), article number: e1002018. (10.1371/journal.pmed.1002018)
- Kotecha, S. J., Adappa, R., Gupta, N., Watkins, W. J., Kotecha, S. and Chakraborty, M. 2015. Safety and efficacy of high-flow nasal cannula therapy in preterm infants: a meta-analysis. Pediatrics 136(3), pp. 542-555. (10.1542/peds.2015-0738)
- Edwards, M. O., Kotecha, S. J., Lowe, J., Richards, L., Watkins, W. J. and Kotecha, S. 2015. Early-term birth is a risk factor for wheezing in childhood: a cross-sectional population study. Journal of Allergy and Clinical Immunology 136(3), pp. 581-587.e2. (10.1016/j.jaci.2015.05.005)
- Watts, P., Jewsbury, H., Okeya, M., Watkins, W. J. and Kotecha, S. 2015. Visual acuity and associations in children with high hypermetropia. Journal of AAPOS 19(4), pp. e67-e68. (10.1016/j.jaapos.2015.07.218)
- Kotecha, S. J., Watkins, W. J., Henderson, A. J. and Kotecha, S. 2015. The effect of birth weight on lung spirometry in white, school-aged children and adolescents born at term: a longitudinal population based observational cohort study. The Journal of Pediatrics 166(5), pp. 1163-1167. (10.1016/j.jpeds.2015.01.002)
- Lowe, J., Watkins, W., Kotecha, S., Edwards, M., Henderson, A. J. and Kotecha, S. 2015. Physical activity in school-age children born preterm. The Journal of Pediatrics 166(4), pp. 877-883. (10.1016/j.jpeds.2014.12.013)
- Edwards, M., Kotecha, S. J., Lowe, J., Watkins, W., Henderson, A. J. and Kotecha, S. 2015. Effect of preterm birth on exercise capacity: a systematic review and meta-analysis. Pediatric Pulmonology 50(3), pp. 293-301. (10.1002/ppul.23117)
- Kotecha, S., Edwards, M., Watkins, W., Lowe, J., Henderson, A. J. and Kotecha, S. 2015. Effect of bronchodilators on forced expiratory volume in 1 s in preterm-born participants aged 5 and over: a sytematic review. Neonatology 107(3), pp. 231-240. (10.1159/000371539)
- Paranjothy, S., Watkins, W. J., Rolfe, K., Adappa, R., Gong, Y., Dunstan, F. D. J. and Kotecha, S. 2014. Perinatal outcomes and travel time from home to hospital: Welsh data 1995 to 2009. Acta Paediatrica 103(12), pp. e522-e527. (10.1111/apa.12800)
- Edwards, M., Watkins, W., Kotecha, S., Halcox, J. P., Dunstan, F., Henderson, A. J. and Kotecha, S. 2014. Higher systolic blood pressure with normal vascular function measurements in preterm-born children. Acta Paediatrica 103(9), pp. 904-912. (10.1111/apa.12699)
- Lowe, J., Watkins, W., Edwards, M., Spiller, O., Jacqz-Aigrain, E., Kotecha, S. and Kotecha, S. 2014. Association between pulmonary Ureaplasma colonization and bronchopulmonary dysplasia in preterm infants: updated systematic review and meta-analysis. The Pediatric Infectious Disease Journal 33(7), pp. 697-702. (10.1097/INF.0000000000000239)
- Pickerd, N., Williams, E. M., Watkins, W. and Kotecha, S. 2014. Tidal breathing in preterm infants receiving and weaning from continuous positive airway pressure. The Journal of Pediatrics 164(5), pp. 1058-1063.e1. (10.1016/j.jpeds.2013.12.049)
- Whyte, L., Kotecha, S., Watkins, W. and Jenkins, H. 2014. Coeliac disease is more common in children with high socio-economic status. Acta Paediatrica 103(3), pp. 289-294. (10.1111/apa.12494)
- Graham, E. A. M. et al. 2014. Defining background DNA levels found on the skin of children aged 0-5 years. International Journal of Legal Medicine 128(2), pp. 251-258. (10.1007/s00414-013-0906-8)
- Paranjothy, S., Dunstan, F. D. J., Watkins, W. J., Hyatt, M., Demmler, J. C., Lyons, R. A. and Fone, D. L. 2013. Gestational age, birth weight, and risk of respiratory hospital admission in childhood. Pediatrics 132(6), pp. e1562-e1569. (10.1542/peds.2013-1737)
- Davies, M., Maguire, S. A., Okolie, C., Watkins, W. J. and Kemp, A. M. 2013. How much do parents know about first aid for burns?. Burns 39(6), pp. 1083-1090. (10.1016/j.burns.2012.12.015)
- Kotecha, S. J., Edwards, M. O., Watkins, W. J., Henderson, A. J., Paranjothy, S., Dunstan, F. D. J. and Kotecha, S. 2013. Effect of preterm birth on later FEV1: a systematic review and meta-analysis. Thorax 68(8), pp. 760-766. (10.1136/thoraxjnl-2012-203079)
- Paranjothy, S., Watkins, W., Rolfe, K., Gong, Y., Adappa, R., Dunstan, F. D. J. and Kotecha, S. 2013. Perinatal outcomes and travel time to maternity services: analysis of birth outcome data in Wales from 1995 to 2009. Archives of Disease in Childhood. Fetal and neonatal edition 98(Suppl), pp. A94. (10.1136/archdischild-2013-303966.323)
- Maguire, S. A. et al. 2012. Retinal haemorrhages and related findings in abusive and non-abusive head trauma: a systematic review. Eye 27, pp. 28-36. (10.1038/eye.2012.213)
- Joshi, S., Powell, T., Watkins, W. J., Drayton, M., Williams, E. M. and Kotecha, S. 2012. Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy. The Journal of Pediatrics 162(4), pp. 813-818. (10.1016/j.jpeds.2012.09.040)
- Lyons, R. A. et al. 2012. Development and use of a privacy-protecting total population record linkage system to support observational, interventional, and policy relevant research. The Lancet 380, article number: S6. (10.1016/S0140-6736(13)60362-1)
- Kotecha, S. J., Watkins, W. J., Paranjothy, S., Dunstan, F. D. J., Henderson, A. J. and Kotecha, S. 2011. Effect of late preterm birth on longitudinal lung spirometry in school age children and adolescents. Thorax 67(1), pp. 54-61. (10.1136/thoraxjnl-2011-200329)
- Watkins, W. J., Roberts, Z. E. S., Dunstan, F. D. J., King, W. and Fone, D. L. 2011. An investigation through microsimulation of the inequities in Coronary Heart Disease (CHD) mortality and morbidity in Wales [Abstract]. Journal of Epidemiology and Community Health 65(S2), pp. A11-A12. (10.1136/jech.2011.143586.25)
- Kotecha, S., Watkins, W. J., Heron, J., Henderson, J., Dunstan, F. D. J. and Kotecha, S. J. 2010. An analysis of the effect of intrauterine growth retardation on spirometric lung function measures of 8-year-old children [Abstract]. Journal of Epidemiology & Community Health 64(Supp 1), pp. A24. (10.1136/jech.2010.120956.60)
- Kotecha, S. J., Watkins, W. J., Heron, J., Henderson, J., Dunstan, F. D. J. and Kotecha, S. 2010. Spirometric lung function in school-age children: Effect of intrauterine growth retardation and catch-up growth. American Journal of Respiratory and Critical Care Medicine 181(9), pp. 969-974. (10.1164/rccm.200906-0897OC)
- Watkins, W., Kennedy, D. and Williams, F. 1999. Efficient parallel solution of structural eigenvalue problems. Advances in Engineering Software 25(2-3), pp. 281-289. (10.1016/0965-9978(95)00094-1)
- Watkins, W. J., Kennedy, D. and Williams, F. W. 1997. On estimating machine dependency of fine- and coarse-grained parallel structural computations. Computer-Aided Civil and Infrastructure Engineering 12(2), pp. 119-128. (10.1111/0885-9507.00050)
- Watkins, W. J., Kennedy, D. and Williams, F. 1997. Efficient parallel Gauss-Doolittle matrix triangulation. Computers and Structures 62(1), pp. 185-195. (10.1016/S0045-7949(96)00282-9)
- Nicholson, D. et al. 1996. Results of the first coincident observations by two laser-interferometric gravitational wave detectors. Physics letters. A. 218(3-6), pp. 175-180. (10.1016/0375-9601(96)00438-0)
- Kennedy, D., Watkins, W. J. and Williams, F. W. 1995. Hybrid parallel computation of transcendental structural eigenvalues. AIAA Journal 33(11) (10.2514/3.12966)
Conferences
- Kotecha, S., Cousins, M., Hart, K., Watkins, W. J. and Kotecha, S. 2022. Effect of IUGR and catch-up growth on later lung function in preterm children: prospective cohort study. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1186., (10.1183/13993003.congress-2022.1186)
- Kotecha, E. et al. 2022. Telomere length in preterm-born children with bronchopulmonary dysplasia (BPD). Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1292., (10.1183/13993003.congress-2022.1292)
- Kotecha, S., Hart, K., Cousins, M., Watkins, W. J., Henderson, A. J. and Kotecha, S. 2022. Association of early life factors with prematurity-associated lung disease : prospective cohort study. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1183., (10.1183/13993003.congress-2022.1183)
- Kotecha, S., Gibbons, J., Course, C. W., Evans, E. E., Simpson, S. J., Watkins, W. J. and Kotecha, S. 2022. Systematic review and meta-analysis of FEV1 in preterm born children. Presented at: ERS International Congress, Barcelona, Spain, 4-6 September 2022, Vol. 60. Vol. S66. European Respiratory Society pp. 1172., (10.1183/13993003.congress-2022.1172)
Ymchwil
Cyflwyniad
Er nad yw fy holl waith ymchwil wedi cynnwys gwahanol elfennau o les babanod a phlant, ac mae nifer o ddarnau o waith gyda'u cyhoeddiadau cysylltiedig wedi'u crynhoi isod.
Effeithiau cynaeddfedrwydd a phwysau geni isel ar Spirometry
Dangosodd ymchwiliadau o effeithiau cael eu geni yn ystod y tymor gyda Arafu Twf Mewnwythol (IUGR), hy yn y 10% ysgafnaf ar gyfer oedran beichiogrwydd wrth gymharu â rheolaethau wedi'u pwysoli'n briodol fod gan blant a anwyd yn IUGR o garfan ALSPAC fesurau swyddogaeth ysgyfaint sylweddol is (FEV1, FVC a FEF2575) yn yr oedran ysgol na'r rheolaethau. Wrth edrych yn union ar blant yr IGUR fe ddangoson ni hefyd fod y rhai a oedd yn "dal i fyny", h.y. wedi dod yn bwysau priodol ar gyfer oedran erbyn 8-9 oed â mesurau swyddogaeth ysgyfaint uwch - er nad yn sylweddol - na'r rhai nad oeddent. Gallai'r ddau grŵp hyn gynrychioli'r plant hynny sy'n enetig fach a'r rhai a oedd yn fach adeg eu geni oherwydd rhyw reswm niweidiol h.y. ysmygu mamol.
Kotecha SJ, Watkins WJ , Heron J, Henderson J, Dunstan FD, Kotecha S. Spirometric swyddogaeth ysgyfaint mewn plant oedran ysgol: effaith retardation twf intrauterine a thwf dal i fyny. Cyfnodolyn Americanaidd o feddygaeth resbiradol a gofal critigol. 2010;181(9):969-74. https://doi.org/10.1164/rccm.200906-0897OC
Er mwyn ymchwilio i gynaeddfedrwydd, cymharom swyddogaeth yr ysgyfaint yn 8-9 a 14-17 oed ar gyfer plant a anwyd yn hwyr cyn-dymor (beichiogrwydd 33-34 a 35-36 wythnos) â phlant o oedran tebyg a anwyd yn ystod y tymor (>=37 wythnos beichiogrwydd). Fe wnaethom hefyd gymharu'r rhain â phlant cyn-dymor iawn a anwyd yn 25-32 wythnos beichiogrwydd. Dangosodd y canlyniadau fod gan y plant a anwyd rhwng 33 a 34 wythnos yr un peth i'r 25-32 wythnos, sy'n sylweddol dlotach swyddogaeth yr ysgyfaint yn 8-9 oed na'r term plant ond ni wnaeth y 35-36 o bobl sy'n wythnosol. Cafodd y difrod hwn yn 8-9 eu lliniaru rhywfaint gan 14-17 mlynedd.
Kotecha SJ, Watkins WJ , Paranjothy S, Dunstan FD, Henderson AJ, Kotecha S. Effaith genedigaeth hwyr cyn tymor ar spirometreg ysgyfaint hydredol mewn plant a phobl ifanc oedran ysgol. Thorax. 2012;67(1):54-61. http://dx.doi.org/10.1136/thoraxjnl-2011-200329
Cafodd effaith pwysau geni isel plant tymor yn 8-9 oed ac eto yn 14-17 oed ei asesu eto gan ddefnyddio'r garfan ALSPAC. Modelwyd mesurau swyddogaeth ysgyfaint safonol, wedi'u haddasu ar gyfer rhyw, uchder ac oedran, o ran pwysau geni z-sgôr a'u haddasu ar gyfer rhyw yn ogystal â beichiogrwydd a chylchedd pen a chyplyddion posibl eraill. Roedd mesurau swyddogaeth yr ysgyfaint (FEV1, FVC a FEF2575) yn gysylltiedig yn sylweddol ar 8-9 mlynedd gyda phwysau geni a pharhaodd y perthnasoedd hyn i raddau helaeth ar ôl addasu'r modelau'n llawn. Fodd bynnag, erbyn 14-17 mlynedd, nid oedd y berthynas yn arwyddocaol eto eto gan ddangos lliniaru niwed adeg eu geni erbyn 14-17 oed, h.y. ar ôl glasoed.
Kotecha SJ, Watkins WJ , Henderson AJ, Kotecha S. Effaith pwysau geni ar spirometreg yr ysgyfaint mewn gwyn, plant oedran ysgol a phobl ifanc a anwyd yn y tymor: astudiaeth garfan arsylwadol seiliedig ar boblogaeth hydredol. Dyddlyfr y Pediatrics. 2015; 166(5): 1163-7. https://doi.org/10.1016/j.jpeds.2015.01.002
Aseswyd hefyd y gwahaniaethau rhwng y tymor cynnar (h.y. 37-38 wythnos) a thymor llawn (39+ wythnos). Roedd gan y rhai a anwyd yn y tymor cynnar fesurau spirometreg is na'r rhai a anwyd yn y tymor llawn, er eu bod o fewn yr ystod arferol. Unwaith eto rhwng 14 a 17 mlynedd roedd y gwahaniaethau wedi diflannu.
Kotecha, S. J., Watkins, W . J., Lowe, J., Henderson, A. J., & Kotecha, S. (2016). Effaith genedigaeth gynnar yn y tymor ar symptomau anadlol a swyddogaeth yr ysgyfaint yn ystod plentyndod a glasoed. Pulmonoleg Bediatreg, 51(11), 1212-1221. https://doi.org/10.1002/ppul.23448
Mae twf ffetws ac ennill pwysau ôl-enedigol cyflym yn gysylltiedig â chanlyniadau anadlol niweidiol yn ystod plentyndod. Gwnaethom ymchwilio i weld a oedd y newidiadau hyn yn cael effeithiau andwyol ychwanegol mewn plant cyn tymor o'i gymharu â'r tymor. O garfan o blant cyn-dymor a thymor (n = 4284 a 2865) ymchwiliwyd i ganlyniadau a gafwyd o holiadur anadlol gan ddefnyddio modelau atchweliad wedi'u haddasu. Canfuom fod twf ffetws carlam yn ystod y trimesters 1af a'r 2il yn gysylltiedig â mwy o wheeze‐ever mewn plant a anwyd cyn y tymor. Hefyd roedd ennill pwysau babanod cyflym yn gysylltiedig â mwy o wheeze-erioed gyda phlant a anwyd ≤32 wythnos beichiogrwydd yn dangos cynnydd pwysau cyflym gyda risg uwch bum gwaith o wheeze-erioed o'i gymharu â thymor a anwyd heb ennill pwysau.
John Lowe, Sarah J. Kotecha, William John Watkins, Sailesh Kotecha (2017). Effaith twf ffetws a babanod ar symptomau anadlol mewn plant a aned cyn y tymor Tachwedd 2017 Pulmonoleg Bediatreg 53(2). https://doi.org/10.1002/ppul.23920
Helpu i adnabod cam-drin plant.
Mae ymchwilio i gleisio ar blant ifanc yn chwarae rhan bwysig wrth benderfynu a allai'r plentyn fod wedi bod yn destun camdriniaeth ai peidio. Gallai ffactor fod faint o DNA nad yw'n blentyn a geir o fewn ardal brân. Er mwyn i hyn fod yn ddefnyddiol, yn normal neu'n gefndirol lefelau DNA a geir ar rannau o gorff y plentyn lle dangoswyd bod cleisiau yn flaenorol yn awgrymu bod yn rhaid penderfynu ar gamdriniaeth. Lluniais y data a chynnal y dadansoddiad ystadegol sylfaenol o'r meintioli cyntaf o lefelau DNA cefndir, y plant a'r rhai nad ydynt yn blant, a geir ar groen babanod a phlant ifanc iawn. Er gwaethaf cyswllt agos â gofalwyr a brodyr a chwiorydd, dangosom fod lefelau DNA nad ydynt yn blant a ganfyddir yn isel iawn trwy gyswllt an-gamdriniol arferol.
Graham EAM, Watkins WJ , Dunstan F, Maguire S, Nuttall D, Swinfield CE, et al. Diffinio lefelau DNA cefndir a geir ar groen plant 0-5 oed. International Journal of Legal Medicine 2013:1-8. https://doi.org/10.1007/s00414-013-0906-8
Mecanwaith arall ar gyfer ymchwilio i gleisiau fel dangosyddion posibl o gam-drin yw penderfynu ar gredadwyedd y cleisiau o ystyried esboniad i'r gofalwyr ynghylch yr achos. Ymchwiliwyd i wyth sefyllfa damweiniol – e.e. cwympiadau, anafiadau chwaraeon, digwyddiadau cerbydau modur ac ati - a allai arwain at gleisio a mesur amlder cleisio dilynol mewn gwahanol leoliadau corff. Gwelsom mai anaml y byddai rhai rhannau o gorff y plant yn dangos cleisio ac felly gellid trin cleisiau yma fel dangosyddion wrth ymchwilio i gamdriniaeth bosibl.
Hibberd, O., Nuttall, D., Watson, R.E., Watkins, W.J ., Kemp, A.M., Maguire, S. (2017). Gwelwyd dosbarthiad cleisio plentyndod o wyth mecanwaith o anaf anfwriadol. Archifau Clefydau yn ystod Plentyndod – Awst 2017 102(12):archdischild-2017-312847 http://dx.doi.org/10.1136/archdischild-2017-312847
Astudiaethau poblogaeth – Pwysau geni isel a llygredd
Mae pwysau geni isel (LBW) yn gysylltiedig â marwolaethau cynyddol yn eu babandod, ond mae ei gysylltiad â marwolaethau yn ystod plentyndod a glasoed diweddarach yn llai eglur. Cynhaliwyd astudiaeth poblogaeth o'r holl enedigaethau byw yng Nghymru a Lloegr o 1993 i 2011 (12,355,251 o enedigaethau byw), gan edrych ar farwolaethau a'i brif achosion ar gyfer gwahanol grwpiau pwysau geni hyd at 18 oed. Dangosom trwy atchweliad Cox fod pwysau geni isel eithafol a chymedrol yn gysylltiedig â marwolaethau cynyddol ar bob pwynt hyd at 18 oed ac roeddem hefyd yn gallu defnyddio codau ICD9/10 i weld yr amrywiad mewn achosion marwolaeth gyda'r bandiau pwysau geni.
Watkins, W. J., Kotecha, S. J., & Kotecha, S. (2016). Marwolaethau babanod pwysau geni isel yn fabandod, plentyndod, a glasoed: astudiaeth poblogaeth o Gymru a Lloegr.PLoS Med, 13(5), e1002018. https://doi.org/10.1371/journal.pmed.1002018
Gwnaethom ymchwilio i weld a yw llygredd (PM10, SO2 a NO2) yn gysylltiedig yn wahaniaethol â marwolaethau babanod, babanod newydd-anedig neu ôl-enedigol ac o fewn y rhain, achosion penodol o farwolaethau babanod ar gyfer 7,984,366 o enedigaethau byw rhwng 2001 a 2012 yng Nghymru a Lloegr. Cafodd y 36,485 o farwolaethau babanod (25,110 o fabanod newydd-anedig ac 11,375 o ôl-enedigaeth) eu modelu gydag addasiadau ar gyfer y prif gyd-sylfaenwyr canlynol: amddifadedd, pwysau geni, oedran mamol, rhyw, a genedigaeth luosog. Canfuom fod marwolaethau babanod wedi cynyddu'n sylweddol gyda NO2, PM10, a SO2 pan gymharwyd pumawd llygryddion uchaf ac isaf; fodd bynnag, roedd marwolaethau newyddenedigol yn gysylltiedig yn sylweddol â SO2 ond nid oedd yn gysylltiedig yn sylweddol â NO2 a PM10. Roedd marwolaethau ôl-enedigol yn gysylltiedig yn sylweddol â'r holl lygryddion. Ar gyfer achosion penodol, roedd pob llygrydd yn gysylltiedig yn yr un modd ag achosion endocrin marwolaethau babanod, fodd bynnag, fel arall roeddent yn gysylltiedig yn wahaniaethol ag achosion penodol eraill: Roedd NO2 a PM10 yn gysylltiedig â chynnydd mewn marwolaethau babanod o gamffurfiadau cynhenid y systemau nerfol a gastroberfeddol tra bod SO2 yn gysylltiedig â chynnydd mewn marwolaethau babanod o achosion amenedigol ac o gamffurfiadau'r system gylchrediadol.
Kotecha SJ*, Watkins WJ *, Lowe J, Kotecha S, Cymdeithas wahaniaethol o amlygiad i lygredd aer ar farwolaethau newydd-anedig ac ôl-enedigol yng Nghymru a Lloegr: astudiaeth garfan. PLOS Medicine, Hydref 2020 * Awduron cyntaf ar y cyd. https://doi.org/10.1371/journal.pmed.1003400
Methodoleg newydd – siartiau twf
Mae'r siartiau twf cyfredol yn gweithio ar y rhagosodiad bod twf mewn utero yn digwydd yn yr un modd â thwf ôl-enedigol mor effeithiol i blant cynamserol mae'r twf "coll" mewn utero yn cael ei fodelu yr un ffordd â thwf ôl-enedigol. Nid yw hyn yn wir ac felly fe wnaethom gynnwys dau derm yn ein model, un yn cynrychioli cynnydd pwysau o'r geni ond mae'r llall yn cynrychioli cynnydd pwysau o'r beichiogi. Pan brofwyd ein siartiau twf disgwyliedig newydd gyda data twf gwirioneddol ar gyfer plant a anwyd hyd at 31 wythnos beichiogrwydd, canfuwyd eu bod yn sylweddol fwy cynrychioliadol na'r siartiau presennol.
Modelu cymhellion cyfeirio pwysau rhagfynegol rhyweddol a beichiogrwydd penodol ar gyfer babanod cyn-dymor gan ddefnyddio astudiaeth garfan sy'n seiliedig ar boblogaeth. Adroddiadau Gwyddonol Natur, Chwefror 2020. W. John Watkins, Daniel Farewell, Sujoy Banerjee, Hesham Nasef, Anitha James, Mallinath Chakraborty. https://doi.org/10.1038/s41598-020-60895-6
Methodoleg newydd – rhagfynegiad ail-diwbio
Mewn papur o 2018, gwnaethom ddefnyddio dulliau atchweliad i brofi'r rhagdybiaeth, mewn newydd-anedig ar awyru mecanyddol, y gellir cyfuno mynegai nodweddion cyfradd y galon (HRCi) â model clinigol ar gyfer rhagweld canlyniadau tiwbio (neu aildiwbio) mewn babanod newydd. Gwnaethom ddangos bod modelau aml-effeithiau llinol llinol a ddefnyddir i greu modelau rhagfynegi, gan ddefnyddio newidynnau perthnasol, wedi gwella'r ddealltwriaeth o'r siawns o lwyddiant tiwbio yn sylweddol.
Nitin Goel, Mallinath Chakraborty, William John Watkins a Sujoy Banerjee (2018). Rhagfynegi Canlyniadau Tubation — Model sy'n ymgorffori Mynegai Nodweddion Cyfradd y Galon. The Journal of Pediatrics. Ionawr 2018 https://doi.org/10.1016/j.jpeds.2017.11.037
Mewn papur dilynol yn 2020, gwnaethom ymestyn y gwaith hwn i ddatblygu offeryn cymorth penderfynu prototeip ar gyfer clinigwyr y gellid ei ddefnyddio cyn y extubation i amcangyfrif y siawns o aildiwbio. Cynhyrchwyd prototeip prototeip ychwanegol a ddefnyddiodd fodel goroesi i amcangyfrif y tebygolrwydd o ail-diwbio yn y cyfnod ar ôl plygu. Roedd y rhyngwyneb graffigol yn darparu amcangyfrif diweddaradwy o'r gromlin perygl (tebygolrwydd ar unwaith o aildiwbio).
Chakraborty, M.*, Watkins, W. J.*, Tansey, K., King, W. E., & Banerjee, S. (2020). Rhagfynegi canlyniadau tiwbiau gan ddefnyddio Mynegai Nodweddion Cyfradd y Galon mewn Babanod Cynamserol: Astudiaeth garfan. European Respiratory Journal. *Awduron cyntaf ar y cyd https://doi.org/10.1183/13993003.01755-2019
Gwichian
Deellir effaith negyddol cynaeddfedrwydd ar swyddogaeth resbiradol trwy gydol plentyndod ond roedd effeithiau cael eu geni yn y Tymor Cynnar (37-38 wythnos) yn aneglur. Fel rhan o astudiaeth holiadur o blant 1-10 oed, roeddem yn gallu cymharu 545 o enedigaethau tymor cynnar gyda 2,300 yn enedigaethau tymor llawn. Roedd gan blant a aned yn y tymor cynnar gyfraddau sylweddol uwch o dderbyniadau i'r ysbyty yn ystod eu blwyddyn gyntaf o fywyd. Wrth gael eu grwpio i lai na 5 mlwydd oed a mwy na 5 mlwydd oed, canfuom fod plant a aned yn y tymor cynnar yn y ddau grŵp yn dweud eu bod yn llawer mwy o wich ac yn fwy diweddar yn siglo er bod y gwahaniaethau yn fwy amlwg yn y grŵp iau. Parhaodd y gwahaniaethau hyn pan gynhwyswyd hanes teuluol atopi a chyflwyno trwy adrannau cesaraidd mewn modelau atchweliad logistaidd a ddefnyddiwyd.
Edwards MO, Kotecha SJ, Lowe J, Richards L, Watkins WJ, Kotecha S. Mae genedigaeth gynnar yn ffactor risg ar gyfer gwichian yn ystod plentyndod: Astudiaeth poblogaeth drawstoriadol. Journal of Allergy and Clinical Immunology. 2015. https://doi.org/10.1016/j.jaci.2015.05.005
Yn yr un astudiaeth ag uchod, gwnaethom ymchwilio i rôl ystumio i'r graddau y mae hanes teuluol o Atopy yn effeithio ar nifer yr achosion o wheezing mewn plentyndod. Dangosodd y rhai dan 5 oed a'r rhai dros 5 oed fwy o siawns o ymgodymu â cynaeddfedrwydd yn sylweddol, a gwaethygodd hynny gyda mwy o gynaeddfedrwydd. Ni welwyd unrhyw berthynas ag atodlen deuluol.
Edwards, M. O., Kotecha, S. J., Lowe, J., Richards, L., Watkins, W. J ., & Kotecha, S. (2016). Rheoli wheeze sy'n gysylltiedig cyn-aeddfedrwydd a'i gysylltiad ag atopy. PloS un, 11(5), e0155695. https://10.1371/journal.pone.0155695
Edrychodd dau bapur dilynol ar y berthynas rhwng ffactorau bywyd cynnar a phenoteipiau chwifio yn ystod plentyndod a ddiffinnir fel dim chwinciad, gwendid cynnar, chwiliedydd hwyr a thrychian barhaus a benderfynwyd gan wheeze yn 3, 5, 7 ac 11 oed ar gyfer plant o Astudiaeth Carfan y Mileniwm a anwyd rhwng 2000 a 2002. Roedd y papur cyntaf yn edrych ar blant cyn y tymor a phlant gyda ffactorau eraill fel ysmygu, atopi a rhyw wedi'u haddasu ar eu cyfer. Roedd gan blant a aned yn y cyfnod ffenoteipiau gwenyn tebyg i blant a anwyd yn ystod y tymor er i ni weld cyfraddau uwch o wheeze cynnar a pharhaus ar y grŵp cyn-dymor.
Sarah J Kotecha, W John Watkins, John Lowe, Raquel Granell, A John Henderson, Sailesh Kotecha; (2019) Cymhariaeth o Gymdeithasau Ffactorau Bywyd Cynnar ar Phenoteipiau Wheezing mewn Plant a Aned yn Nhymor a Phlant a Ganwyd, American Journal of Epidemiology, , kwy268, https://doi.org/10.1093/aje/kwy268
Edrychodd yr ail bapur ar effaith twf dal i fyny mewn genedigaethau tymor o'r un set ddata. Gwnaethom ddangos y gallai twf dal i fyny - a ddiffinnir fel newid mewn sgôr z-safonol o 0.67 o ran oedran a rhyw - fod yn gysylltiedig â mwy o siawns o whesian cynnar er y gallai hyn gael ei liniaru gan welliannau tymor hir.
Kotecha SJ, Lowe J, Granell R, W. John Watkins, et al. Effaith twf dal i fyny ym mlwyddyn gyntaf bywyd ar ffenoteipiau chwim yn ddiweddarach. Eur Respir J 2020; 56: 2000884 https://doi.org/10.1183/13993003.00884-2020
Addysgu
| Teitl y modiwl/Cwrs | Lefel | Oriau Cyswllt | Rôl | |
|
MSc mewn Imiwnoleg Glinigol ac Arbrofol Gymhwysol |
Msc |
15 yn ogystal ag un i un yn ôl yr angen |
Darlithydd/Setiwr prosiect |
|
|
MET582 (Ystadegau Biowybodeg ac Epidemioleg Genynnol), fel rhan o'r MSc Biowybodeg. |
Msc |
15 yn ogystal ag un i un yn ôl yr angen |
Darlithydd |
|
|
2il flwyddyn Meddygaeth Myfyriwr Dethol Elfen (SSC) |
2il flwyddyn meddygaeth israddedig |
2 wythnos |
Goruchwyliwr / Hyfforddwr |
|
|
ME3406 modiwl ar gyfer Argyfwng, Cyn-ysbyty a Gofal Brys BSc Rhyng-gyfrifedig (EPIC) |
undergrad |
Hanner diwrnod ynghyd â nifer fawr o un i un |
Darlithydd/Tiwtor |
Bywgraffiad
Trosolwg gyrfa
- 2022 – Nawr: Uwch Ddarlithydd, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2016 – 2022: Uwch Ystadegydd Meddygol a Darlithydd, Ysgol Meddygaeth, Prifysgol Caerdydd
- 2008 – 2016: Ystadegydd Meddygol, Prifysgol Caerdydd
- 2002 – 2008: Uwch Beiriannydd Systemau, General Dynamics UK
- 1999 – 2002: Uwch Beiriannydd Meddalwedd ac Arweinydd Tîm, Ascom Telecommunications, Caerdydd
- 1997 – 1999: Cydymaith Ymchwil, Asiantaeth Radiogyfathrebu/Prifysgol Caerdydd
- 1996 – 1997: Cymorth TG a Meddalwedd, Prifysgol Caerdydd
- 1992 – 1996: Cydymaith Ymchwil, Ysgol Peirianneg, Prifysgol Caerdydd
- 1987 – 1992: Darlithydd/Tiwtor Rhan Amser, Prifysgol Caerdydd
Addysg a chymwysterau
- 2006: Diploma mewn Ystadegau, Y Brifysgol Agored
- 1991: PhD (Astroffiseg, Mathemateg Gymhwysol, Cyfrifiadura), Prifysgol Caerdydd
- 1987: BSc (Mathemateg), Prifysgol Caerdydd
Ymgysylltu
Fi yw'r ymgynghorydd ystadegol allanol i'r Grŵp Cynghori Arbenigol Meddyginiaethau Pediatrig (PMEAG). Rydym yn eistedd bob mis, gan archwilio treialon a chyhoeddiadau meddygol gyda'r bwriad o gynghori llywodraeth y DU o ansawdd y treial ac effeithiolrwydd y feddyginiaeth. Yn arwyddocaol, mae ymdrechion diweddar wedi cynnwys gwerthuso treialon clinigol brechlynnau Covid i blant ifanc, gyda chanlyniadau uniongyrchol wrth ddatblygu canllawiau cenedlaethol yn gyflym.
Contact Details
+44 29208 74000 ext 20128
Adeilad Ymchwil Cardiofasgwlaidd Syr Geraint Evans, Ystafell 1.14, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN