![Isabella Willcocks BSc, MSc, PhD](https://profiles-cardiff.imgix.net/attachments/4827?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Isabella Willcocks
(hi/ei)
BSc, MSc, PhD
Cydymaith Ymchwil, Is-adran Meddygaeth Seicolegol a Niwrowyddorau Clinigol
- WillcocksIR@caerdydd.ac.uk
- Adeilad Hadyn Ellis, Heol Maendy, Caerdydd, CF24 4HQ
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Cydymaith ymchwil sy'n gweithio yn thema ymchwil seicosis y Ganolfan Geneteg a Genomeg Niwroseiciatrig, gan ganolbwyntio'n bennaf ar amrywiad genetig cyffredin mewn sgitsoffrenia sy'n gwrthsefyll triniaeth, a sut mae'n wahanol i sgitsoffrenia sy'n gwrthsefyll triniaeth
Cyhoeddiad
2023
- Lock, S. K. et al. 2023. Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count. Schizophrenia 9, article number: 74. (10.1038/s41537-023-00404-6)
- Kappel, D. B. et al. 2023. Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores. Biological Psychiatry 93, pp. 149-156. (10.1016/j.biopsych.2022.07.014)
2022
- Willcocks, I. 2022. The genomic stratification of schizophrenia. PhD Thesis, Cardiff University.
- Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79(3), pp. 260-269. (10.1001/jamapsychiatry.2021.3799)
2021
- Willcocks, I. et al. 2021. Clozapine metabolism is associated with absolute neutrophil count in individuals with treatment-resistant schizophrenia. Frontiers in Pharmacology 12, article number: 658734. (10.3389/fphar.2021.658734)
2020
- Grama, S. et al. 2020. Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort. Translational Psychiatry 10, article number: 309. (10.1038/s41398-020-00940-0)
Erthyglau
- Lock, S. K. et al. 2023. Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count. Schizophrenia 9, article number: 74. (10.1038/s41537-023-00404-6)
- Kappel, D. B. et al. 2023. Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores. Biological Psychiatry 93, pp. 149-156. (10.1016/j.biopsych.2022.07.014)
- Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79(3), pp. 260-269. (10.1001/jamapsychiatry.2021.3799)
- Willcocks, I. et al. 2021. Clozapine metabolism is associated with absolute neutrophil count in individuals with treatment-resistant schizophrenia. Frontiers in Pharmacology 12, article number: 658734. (10.3389/fphar.2021.658734)
- Grama, S. et al. 2020. Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort. Translational Psychiatry 10, article number: 309. (10.1038/s41398-020-00940-0)
Gosodiad
- Willcocks, I. 2022. The genomic stratification of schizophrenia. PhD Thesis, Cardiff University.
Ymchwil
Rwyf wedi gweithio gyda gweithgor sgitsoffrenia y PGC fel dadansoddwr cofrestredig. Rwyf bellach yn gweithio fel rhan o Psych-STRATA, prosiect rhyngwladol aml-ganolfan a ariennir gan Horizon Europe yn edrych ar ymateb triniaeth mewn sgitsoffrenia, anhwylder deubegynol ac iselder mawr.
Bywgraffiad
Ar ôl cwblhau fy ngradd israddedig mewn niwrowyddoniaeth a gradd meistr mewn niwrowyddoniaeth foleciwlaidd ym Mhrifysgol Bryste, dechreuais fy PhD yn 2018 a ariannwyd gan yr MRC yn y Ganolfan Geneteg a Genomeg Niwroseiciatrig. Cwblheais fy PhD dan oruchwyliaeth yr Athro James Walters a Dr Antonio Pardiñas. Canolbwyntiodd fy PhD ar haeniad genomig sgitsoffrenia, a sut y gallai gwahanu cyfranogwyr ymchwil i is-grwpiau cleifion mwy homogenaidd hwyluso dull meddygaeth mwy personol wrth drin sgitsoffrenia
Mae fy ngwaith bellach yn canolbwyntio ar amrywiad genetig cyffredin mewn sgitsoffrenia sy'n gwrthsefyll triniaeth fel rhan o Psych-STRATA®, prosiect rhyngwladol aml-ganolfan a ariennir gan Horizon Europe
Anrhydeddau a dyfarniadau
Guarantors of Brain 2023: Gwobr Teithio ECR
Cymdeithas Geneteg 2023: Gwobr Teithio ECR
WCPG 2022: Rhaglen Ymchwilydd Gyrfa Gynnar Poster yn rownd derfynol
Themâu ymchwil
Arbenigeddau
- Sgitsoffrenia
- Ymwrthedd Triniaeth