![Catrin Williams BSc, PhD, FHEA](https://profiles-cardiff.imgix.net/attachments/1261?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Catrin Williams
(hi/ei)
BSc, PhD, FHEA
- Siarad Cymraeg
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Timau a rolau for Catrin Williams
Darlithydd
Ysgol y Biowyddorau
Trosolwyg
Rwy'n ficrobiolegydd yn Ysgol y Biowyddorau Prifysgol Caerdydd, lle rwy'n archwilio ffyrdd arloesol o ganfod a thrin pathogenau dynol ac anifeiliaid. Mae fy ymchwil yn dwyn ynghyd ddisgyblaethau gwyddonol amrywiol i archwilio heriau byd-eang dybryd, o ymwrthedd gwrthficrobaidd i wyddoniaeth microbiome a datblygu technolegau canfod cyflym. Rwy'n arwain tîm o fewn y grŵp Microbiomau, Microbau a Gwybodeg (MMI) ac yn cydweithio'n eang ar draws y pynciau STEM. Rwy'n angerddol am ymgysylltu â'r cyhoedd, yn enwedig drwy gyfrwng y Gymraeg, ac rwy'n ymrwymedig i ysbrydoli'r genhedlaeth nesaf o ferched a menywod mewn gwyddoniaeth. Rwy'n addysgu ar draws sawl modiwl israddedig ac rwy'n goruchwylio prosiectau ymchwil myfyrwyr ar lefelau israddedig, Meistr a PhD. Rwyf bob amser yn awyddus i glywed gan ddarpar gydweithwyr neu fyfyrwyr sydd â diddordeb mewn ymuno â'm grŵp ymchwil, felly mae croeso i chi gysylltu â ni.
Cyhoeddiad
2025
- Miles, A., Porch, A., Choi, H., Cripps, S., Brown, H. and Williams, C. F. 2025. Direct measurement of non-thermal microwave effects on bacterial growth and redox dynamics using a novel high-throughput waveguide applicator. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 383(2297), article number: 20240073. (10.1098/rsta.2024.0073)
2023
- Williams, C. F. et al. 2023. Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz. Biochemical and Biophysical Research Communications 661, pp. 89-98. (10.1016/j.bbrc.2023.04.038)
2022
- Williams, C. F. 2022. Microbial metabolism. In: Rezaei, N. ed. Encyclopedia of Infection and Immunity., Vol. 1. Elsevier, pp. 363-376., (10.1016/B978-0-12-818731-9.00188-9)
2020
- Ahortor, E. K., Malyshev, D., Williams, C. F., Choi, H., Lees, J., Porch, A. and Baillie, L. 2020. The biological effect of 2.45 GHz microwaves on the viability and permeability of bacterial and yeast cells. Journal of Applied Physics 127(204902), pp. IMPORTED. (10.1063/1.5145009)
- Lloyd, D. et al. 2020. Functional imaging of a model unicell: Spironucleus vortens as an anaerobic but aerotolerant flagellated protist. Advances in Microbial Physiology 76, pp. 41-79. (10.1016/bs.ampbs.2020.01.002)
2019
- Williams, C. F. et al. 2019. Bioluminescence of Vibrio fischeri: bacteria respond quickly and sensitively to pulsed microwave electric (but not magnetic) fields. Journal of Biomedical Optics 24(5), article number: 51412. (10.1117/1.JBO.24.5.051412)
- Malyshev, D., Williams, C. F., Lees, J., Baillie, L. and Porch, A. 2019. Model of microwave effects on bacterial spores. Journal of Applied Physics 125(12), article number: 124701. (10.1063/1.5085442)
- Groves, L. M. et al. 2019. Fluorescent functionalised naphthalimides and their Au(i)–NHC complexes for potential use in cellular bioimaging. Dalton Transactions 48(5), pp. 1599-1612. (10.1039/C8DT04069A)
- Williams, C. and George, C. 2019. Connect and conquer: collectivized behavior of mitochondria and bacteria. Frontiers in Physiology, pp. -. (10.3389/fphys.2019.00340)
2018
- Williams, C. et al. 2018. Real-time microscopic observation of biological interactions with microwave fields. Presented at: International Microwave Biomedical Conference (IMBioC), Philadelphia, USA, 14-15 Jun 2018International Microwave Biomedical Conference (IMBioC). IEEE pp. 199., (10.1109/IMBIOC.2018.8428902)
- Leitsch, D., Williams, C. F. and Hrdy, I. 2018. Redox pathways as drug targets in microaerophilic parasites. Trends in Parasitology 34(7), pp. 576-589. (10.1016/j.pt.2018.04.007)
2017
- Langdon-Jones, E. E. et al. 2017. Luminescent 1,8-Naphthalimide-Derived ReI Complexes: syntheses, spectroscopy, X-ray structure and preliminary bioimaging in fission yeast cells. European Journal of Inorganic Chemistry 2017(44), pp. 5279-5287. (10.1002/ejic.201700549)
- Pope, S. J. A., Langdon-Jones, E., Jones, A., Williams, C. F., Hayes, A. J., Lloyd, D. and Mottram, H. J. 2017. Anticancer, azonafide-inspired fluorescent ligands and their rhenium(I) complexes for cellular imaging. European Journal of Inorganic Chemistry 2017(3), pp. 759-766. (10.1002/ejic.201601271)
- Williams, C. F. et al. 2017. Corrigendum to The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens [Mol. Biochem. Parasitol. 206 (1-2) (2016) 20-28]. Molecular and Biochemical Parasitology 211, pp. 104. (10.1016/j.molbiopara.2016.07.007)
2016
- Williams, C. F. et al. 2016. What the deep sea can tell us about microwaves. Presented at: International Microwave Symposium IMS, San Francisco, California, 22-27 May 2016Microwave Symposium (IMS), 2016 IEEE MTT-S International. IEEE, (10.1109/MWSYM.2016.7540432)
- Williams, C. F., Geroni, G. M., Pirog, A., Lloyd, D., Lees, J. and Porch, A. 2016. The separated electric and magnetic field responses of luminescent bacteria exposed to pulsed microwave irradiation. Applied Physics Letters 109(9), article number: 93701. (10.1063/1.4961970)
- Williams, C. F. et al. 2016. The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens. Molecular and Biochemical Parasitology 206(1-2), pp. 20-28. (10.1016/j.molbiopara.2016.03.001)
2015
- Lloyd, D. and Williams, C. F. 2015. Avoid excessive oxygen levels in experiments with organisms, tissues and cells.. Advances in Microbial Physiology 67, pp. 293--314. (10.1016/bs.ampbs.2015.09.001)
- Stacey, O. J. et al. 2015. Water soluble, cyclometalated Pt(II)–Ln(III) conjugates towards novel bimodal imaging agents. Chemical Communications 51(61), pp. 12305-12308. (10.1039/C5CC02623G)
- Lloyd, D. and Williams, C. F. 2015. New tunes from the heart. Biophysical Journal 108(8), pp. 1841-1842. (10.1016/j.bpj.2015.01.041)
- Williams, C. f., Walton, G. E., Jiang, L., Plummer, S., Garaiova, I. and Gibson, G. R. 2015. Comparative analysis of intestinal tract models. Annual Review of Food Science and Technology 6(1), pp. 329-350. (10.1146/annurev-food-022814-015429)
- Lloyd, D., Lewis, I. B., Williams, C. F., Hayes, A. J., Symons, H. and Hill, E. C. 2015. Motility of the diplomonad fish parasite Spironucleus vortens through thixotropic solid media. Microbiology 161(1), pp. 213-218. (10.1099/mic.0.082529-0)
2014
- Lloyd, D. and Williams, C. F. 2014. Comparative biochemistry of Giardia, Hexamita and Spironucleus: Enigmatic diplomonads. Molecular and Biochemical Parasitology 197(1-2), pp. 43-49. (10.1016/j.molbiopara.2014.10.002)
- Williams, C. F., Yarlett, N., Aon, M. A. and Lloyd, D. 2014. Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol. Molecular and Biochemical Parasitology 196(1), pp. 45-52. (10.1016/j.molbiopara.2014.07.010)
- Lloyd, D. et al. 2014. Intracellular oxygen: similar results from two methods of measurement using Phosphorescent nanoparticles. Journal of Innovative Optical Health Sciences 7(2), article number: 1350041. (10.1142/S1793545813500417)
2013
- Millet, C. O. M., Williams, C. F., Hayes, A. J., Hann, A. C., Cable, J. and Lloyd, D. 2013. Mitochondria-derived organelles in the diplomonad fish parasite Spironucleus vortens. Experimental Parasitology 135(2), pp. 262-273. (10.1016/j.exppara.2013.07.003)
- Williams, C. F., Millet, C. O., Hayes, A. J., Cable, J. and Lloyd, D. 2013. Diversity in mitochondrion-derived organelles of the parasitic diplomonads Spironucleus and Giardia. Trends in Parasitology 29(7), pp. 311-312. (10.1016/j.pt.2013.04.004)
- Pritchard, V. E. et al. 2013. Simple Polyphenyl Zirconium and Hafnium Metallocene Room-Temperature Lumophores for Cell Imaging. Organometallics 32(12), pp. 3566-3569. (10.1021/om400212y)
- Williams, C. F. 2013. Life cycle, biochemistry and chemotherapy of Spironucleus vortens. PhD Thesis, Cardiff University.
- Leitsch, D., Williams, C. F., Lloyd, D. and Duchêne, M. 2013. Unexpected properties of NADP-dependent secondary alcohol dehydrogenase (ADH-1) in Trichomonas vaginalis and other microaerophilic parasites. Experimental Parasitology 134(3), pp. 374-380. (10.1016/j.exppara.2013.03.034)
- Williams, C. F., Vacca, A. R., Lloyd, D., Schelkle, B. and Cable, J. 2013. Non-invasive investigation of Spironucleus vortens transmission in freshwater angelfish Pterophyllum scalare. Diseases of Aquatic Organisms 105(3), pp. 211-223. (10.3354/dao02618)
2012
- Joshi, L. T., Phillips, D. S., Williams, C. F., Alyousef, A. and Baillie, L. 2012. Contribution of Spores to the Ability of Clostridium difficile To Adhere to Surfaces. Applied and Environmental Microbiology 78(21), pp. 7671-7679. (10.1128/AEM.01862-12)
- Williams, C. F. et al. 2012. Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds. Veterinary Parasitology 190(1-2), pp. 62-73. (10.1016/j.vetpar.2012.05.011)
- Balasingham, R., Williams, C. F., Mottram, H. J., Coogan, M. P. and Pope, S. J. A. 2012. Gold(I) complexes derived from alkynyloxy-substituted anthraquinones: Syntheses, luminescence, preliminary cytotoxicity, and cell imaging studies. Organometallics 31(16), pp. 5835-5843. (10.1021/om300475y)
- Fernández-Moreira, V., Ortego, M. L., Williams, C. F., Coogan, M. P., Villacampa, M. D. and Gimeno, M. C. 2012. Bioconjugated rhenium(I) complexes with amino acid derivatives: synthesis, photophysical properties, and cell imaging studies. Organometallics 31(16), pp. 5950-5957. (10.1021/om300610j)
- Williams, C. F., Kombrabail, M., Vijayalakshmi, K., White, N., Krishnamoorthy, G. and Lloyd, D. 2012. Evaluation of two novel methods for assessing intracellular oxygen. Measurement Science and Technology 23(8), article number: 84005. (10.1088/0957-0233/23/8/084005)
- Balasingham, R. G., Thorp-Greenwood, F. L., Williams, C. F., Coogan, M. P. and Pope, S. J. A. 2012. Biologically compatible, phosphorescent dimetallic rhenium complexes linked through functionalized alkyl chains: syntheses, spectroscopic properties, and applications in imaging microscopy. Inorganic Chemistry 51(3), pp. 1419-1426. (10.1021/ic201654d)
2011
- Millet, C. O., Lloyd, D., Williams, C. F., Williams, D., Evans, G., Saunders, R. and Cable, J. 2011. Effect of garlic and allium-derived products on the growth and metabolism of Spironucleus vortens. Experimental Parasitology 127(2), pp. 490-499. (10.1016/j.exppara.2010.10.001)
- Williams, C. F., Lloyd, D., Poynton, S. L., Jorgensen, A., Millet, C. O. and Cable, J. 2011. Spironucleus species: economically-important fish pathogens and enigmatic single-celled eukaryotes. Journal of Aquaculture Research & Development(S2), article number: 2. (10.4172/2155-9546.S2-002)
- Millet, C. O., Lloyd, D., Williams, C. F. and Cable, J. 2011. In vitro culture of the diplomonad fish parasite Spironucleus vortens reveals unusually fast doubling time and atypical biphasic growth. Journal of Fish Diseases 34(1), pp. 71-73. (10.1111/j.1365-2761.2010.01213.x)
- Thorp-Greenwood, F. L. et al. 2011. A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging. Chemical Communications 47(11), pp. 3096-3098. (10.1039/c1cc10141b)
2010
- Fernández-Moreira, V. et al. 2010. Uptake and localisation of rhenium fac-tricarbonyl polypyridyls in fluorescent cell imaging experiments. Organic and Biomolecular Chemistry 8(17), pp. 3888-3901. (10.1039/c004610h)
Adrannau llyfrau
- Williams, C. F. 2022. Microbial metabolism. In: Rezaei, N. ed. Encyclopedia of Infection and Immunity., Vol. 1. Elsevier, pp. 363-376., (10.1016/B978-0-12-818731-9.00188-9)
Cynadleddau
- Williams, C. et al. 2018. Real-time microscopic observation of biological interactions with microwave fields. Presented at: International Microwave Biomedical Conference (IMBioC), Philadelphia, USA, 14-15 Jun 2018International Microwave Biomedical Conference (IMBioC). IEEE pp. 199., (10.1109/IMBIOC.2018.8428902)
- Williams, C. F. et al. 2016. What the deep sea can tell us about microwaves. Presented at: International Microwave Symposium IMS, San Francisco, California, 22-27 May 2016Microwave Symposium (IMS), 2016 IEEE MTT-S International. IEEE, (10.1109/MWSYM.2016.7540432)
Erthyglau
- Miles, A., Porch, A., Choi, H., Cripps, S., Brown, H. and Williams, C. F. 2025. Direct measurement of non-thermal microwave effects on bacterial growth and redox dynamics using a novel high-throughput waveguide applicator. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 383(2297), article number: 20240073. (10.1098/rsta.2024.0073)
- Williams, C. F. et al. 2023. Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz. Biochemical and Biophysical Research Communications 661, pp. 89-98. (10.1016/j.bbrc.2023.04.038)
- Ahortor, E. K., Malyshev, D., Williams, C. F., Choi, H., Lees, J., Porch, A. and Baillie, L. 2020. The biological effect of 2.45 GHz microwaves on the viability and permeability of bacterial and yeast cells. Journal of Applied Physics 127(204902), pp. IMPORTED. (10.1063/1.5145009)
- Lloyd, D. et al. 2020. Functional imaging of a model unicell: Spironucleus vortens as an anaerobic but aerotolerant flagellated protist. Advances in Microbial Physiology 76, pp. 41-79. (10.1016/bs.ampbs.2020.01.002)
- Williams, C. F. et al. 2019. Bioluminescence of Vibrio fischeri: bacteria respond quickly and sensitively to pulsed microwave electric (but not magnetic) fields. Journal of Biomedical Optics 24(5), article number: 51412. (10.1117/1.JBO.24.5.051412)
- Malyshev, D., Williams, C. F., Lees, J., Baillie, L. and Porch, A. 2019. Model of microwave effects on bacterial spores. Journal of Applied Physics 125(12), article number: 124701. (10.1063/1.5085442)
- Groves, L. M. et al. 2019. Fluorescent functionalised naphthalimides and their Au(i)–NHC complexes for potential use in cellular bioimaging. Dalton Transactions 48(5), pp. 1599-1612. (10.1039/C8DT04069A)
- Williams, C. and George, C. 2019. Connect and conquer: collectivized behavior of mitochondria and bacteria. Frontiers in Physiology, pp. -. (10.3389/fphys.2019.00340)
- Leitsch, D., Williams, C. F. and Hrdy, I. 2018. Redox pathways as drug targets in microaerophilic parasites. Trends in Parasitology 34(7), pp. 576-589. (10.1016/j.pt.2018.04.007)
- Langdon-Jones, E. E. et al. 2017. Luminescent 1,8-Naphthalimide-Derived ReI Complexes: syntheses, spectroscopy, X-ray structure and preliminary bioimaging in fission yeast cells. European Journal of Inorganic Chemistry 2017(44), pp. 5279-5287. (10.1002/ejic.201700549)
- Pope, S. J. A., Langdon-Jones, E., Jones, A., Williams, C. F., Hayes, A. J., Lloyd, D. and Mottram, H. J. 2017. Anticancer, azonafide-inspired fluorescent ligands and their rhenium(I) complexes for cellular imaging. European Journal of Inorganic Chemistry 2017(3), pp. 759-766. (10.1002/ejic.201601271)
- Williams, C. F. et al. 2017. Corrigendum to The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens [Mol. Biochem. Parasitol. 206 (1-2) (2016) 20-28]. Molecular and Biochemical Parasitology 211, pp. 104. (10.1016/j.molbiopara.2016.07.007)
- Williams, C. F., Geroni, G. M., Pirog, A., Lloyd, D., Lees, J. and Porch, A. 2016. The separated electric and magnetic field responses of luminescent bacteria exposed to pulsed microwave irradiation. Applied Physics Letters 109(9), article number: 93701. (10.1063/1.4961970)
- Williams, C. F. et al. 2016. The redox-active drug metronidazole and thiol-depleting garlic compounds act synergistically in the protist parasite Spironucleus vortens. Molecular and Biochemical Parasitology 206(1-2), pp. 20-28. (10.1016/j.molbiopara.2016.03.001)
- Lloyd, D. and Williams, C. F. 2015. Avoid excessive oxygen levels in experiments with organisms, tissues and cells.. Advances in Microbial Physiology 67, pp. 293--314. (10.1016/bs.ampbs.2015.09.001)
- Stacey, O. J. et al. 2015. Water soluble, cyclometalated Pt(II)–Ln(III) conjugates towards novel bimodal imaging agents. Chemical Communications 51(61), pp. 12305-12308. (10.1039/C5CC02623G)
- Lloyd, D. and Williams, C. F. 2015. New tunes from the heart. Biophysical Journal 108(8), pp. 1841-1842. (10.1016/j.bpj.2015.01.041)
- Williams, C. f., Walton, G. E., Jiang, L., Plummer, S., Garaiova, I. and Gibson, G. R. 2015. Comparative analysis of intestinal tract models. Annual Review of Food Science and Technology 6(1), pp. 329-350. (10.1146/annurev-food-022814-015429)
- Lloyd, D., Lewis, I. B., Williams, C. F., Hayes, A. J., Symons, H. and Hill, E. C. 2015. Motility of the diplomonad fish parasite Spironucleus vortens through thixotropic solid media. Microbiology 161(1), pp. 213-218. (10.1099/mic.0.082529-0)
- Lloyd, D. and Williams, C. F. 2014. Comparative biochemistry of Giardia, Hexamita and Spironucleus: Enigmatic diplomonads. Molecular and Biochemical Parasitology 197(1-2), pp. 43-49. (10.1016/j.molbiopara.2014.10.002)
- Williams, C. F., Yarlett, N., Aon, M. A. and Lloyd, D. 2014. Antioxidant defences of Spironucleus vortens: Glutathione is the major non-protein thiol. Molecular and Biochemical Parasitology 196(1), pp. 45-52. (10.1016/j.molbiopara.2014.07.010)
- Lloyd, D. et al. 2014. Intracellular oxygen: similar results from two methods of measurement using Phosphorescent nanoparticles. Journal of Innovative Optical Health Sciences 7(2), article number: 1350041. (10.1142/S1793545813500417)
- Millet, C. O. M., Williams, C. F., Hayes, A. J., Hann, A. C., Cable, J. and Lloyd, D. 2013. Mitochondria-derived organelles in the diplomonad fish parasite Spironucleus vortens. Experimental Parasitology 135(2), pp. 262-273. (10.1016/j.exppara.2013.07.003)
- Williams, C. F., Millet, C. O., Hayes, A. J., Cable, J. and Lloyd, D. 2013. Diversity in mitochondrion-derived organelles of the parasitic diplomonads Spironucleus and Giardia. Trends in Parasitology 29(7), pp. 311-312. (10.1016/j.pt.2013.04.004)
- Pritchard, V. E. et al. 2013. Simple Polyphenyl Zirconium and Hafnium Metallocene Room-Temperature Lumophores for Cell Imaging. Organometallics 32(12), pp. 3566-3569. (10.1021/om400212y)
- Leitsch, D., Williams, C. F., Lloyd, D. and Duchêne, M. 2013. Unexpected properties of NADP-dependent secondary alcohol dehydrogenase (ADH-1) in Trichomonas vaginalis and other microaerophilic parasites. Experimental Parasitology 134(3), pp. 374-380. (10.1016/j.exppara.2013.03.034)
- Williams, C. F., Vacca, A. R., Lloyd, D., Schelkle, B. and Cable, J. 2013. Non-invasive investigation of Spironucleus vortens transmission in freshwater angelfish Pterophyllum scalare. Diseases of Aquatic Organisms 105(3), pp. 211-223. (10.3354/dao02618)
- Joshi, L. T., Phillips, D. S., Williams, C. F., Alyousef, A. and Baillie, L. 2012. Contribution of Spores to the Ability of Clostridium difficile To Adhere to Surfaces. Applied and Environmental Microbiology 78(21), pp. 7671-7679. (10.1128/AEM.01862-12)
- Williams, C. F. et al. 2012. Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds. Veterinary Parasitology 190(1-2), pp. 62-73. (10.1016/j.vetpar.2012.05.011)
- Balasingham, R., Williams, C. F., Mottram, H. J., Coogan, M. P. and Pope, S. J. A. 2012. Gold(I) complexes derived from alkynyloxy-substituted anthraquinones: Syntheses, luminescence, preliminary cytotoxicity, and cell imaging studies. Organometallics 31(16), pp. 5835-5843. (10.1021/om300475y)
- Fernández-Moreira, V., Ortego, M. L., Williams, C. F., Coogan, M. P., Villacampa, M. D. and Gimeno, M. C. 2012. Bioconjugated rhenium(I) complexes with amino acid derivatives: synthesis, photophysical properties, and cell imaging studies. Organometallics 31(16), pp. 5950-5957. (10.1021/om300610j)
- Williams, C. F., Kombrabail, M., Vijayalakshmi, K., White, N., Krishnamoorthy, G. and Lloyd, D. 2012. Evaluation of two novel methods for assessing intracellular oxygen. Measurement Science and Technology 23(8), article number: 84005. (10.1088/0957-0233/23/8/084005)
- Balasingham, R. G., Thorp-Greenwood, F. L., Williams, C. F., Coogan, M. P. and Pope, S. J. A. 2012. Biologically compatible, phosphorescent dimetallic rhenium complexes linked through functionalized alkyl chains: syntheses, spectroscopic properties, and applications in imaging microscopy. Inorganic Chemistry 51(3), pp. 1419-1426. (10.1021/ic201654d)
- Millet, C. O., Lloyd, D., Williams, C. F., Williams, D., Evans, G., Saunders, R. and Cable, J. 2011. Effect of garlic and allium-derived products on the growth and metabolism of Spironucleus vortens. Experimental Parasitology 127(2), pp. 490-499. (10.1016/j.exppara.2010.10.001)
- Williams, C. F., Lloyd, D., Poynton, S. L., Jorgensen, A., Millet, C. O. and Cable, J. 2011. Spironucleus species: economically-important fish pathogens and enigmatic single-celled eukaryotes. Journal of Aquaculture Research & Development(S2), article number: 2. (10.4172/2155-9546.S2-002)
- Millet, C. O., Lloyd, D., Williams, C. F. and Cable, J. 2011. In vitro culture of the diplomonad fish parasite Spironucleus vortens reveals unusually fast doubling time and atypical biphasic growth. Journal of Fish Diseases 34(1), pp. 71-73. (10.1111/j.1365-2761.2010.01213.x)
- Thorp-Greenwood, F. L. et al. 2011. A 'Sleeping Trojan Horse' which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging. Chemical Communications 47(11), pp. 3096-3098. (10.1039/c1cc10141b)
- Fernández-Moreira, V. et al. 2010. Uptake and localisation of rhenium fac-tricarbonyl polypyridyls in fluorescent cell imaging experiments. Organic and Biomolecular Chemistry 8(17), pp. 3888-3901. (10.1039/c004610h)
Gosodiad
- Williams, C. F. 2013. Life cycle, biochemistry and chemotherapy of Spironucleus vortens. PhD Thesis, Cardiff University.
Ymchwil
Rwy'n arwain grŵp ymchwil microbioleg sy'n ymroddedig i ddatblygu dulliau arloesol ar gyfer canfod a dileu microbaidd mewn cymwysiadau biofeddygol ac amgylcheddol. Rwy'n cydweithio'n helaeth â pheirianwyr, cemegwyr, bioffisegwyr, clinigwyr a diwydiant i wthio ffiniau disgyblaeth traddodiadol a chymhwyso dulliau arloesol i fynd i'r afael â heriau byd-eang allweddol. Mae fy ymchwil yn cefnogi'r dull OneHealth ac yn cyd-fynd â Nodau Datblygu Cynaliadwy y Cenhedloedd Unedig 3 (Iechyd Da a Lles), 5 (Cydraddoldeb Rhywiol), 9 (Diwydiant, Arloesi a Seilwaith) a 13 (Gweithredu yn yr Hinsawdd).
Mae fy meysydd ffocws presennol yn cael eu crynhoi isod.
Ynni microdon fel offeryn ar gyfer monitro a rheoli bacteriol
Un o brif ffocws ein gwaith yw deall sut mae microbau yn ymateb i feysydd microdon, sy'n ein galluogi i archwilio dulliau cyflym ar gyfer canfod pathogenau. Mae gennym ddiddordeb arbennig mewn sut y gall microdonnau ysgogi athreiddedd cellog a hwyluso rhyddhau biofarcwyr cellog (e.e. DNA) neu ddarparu cargo (e.e. cyffuriau) i gelloedd. Mae gan hyn botensial cyffrous i fynd i'r afael â heriau fel ymwrthedd gwrthficrobaidd a rheoli heintiau mewn lleoliadau clinigol ac amgylcheddol.
Rhyngweithiadau gwesteiwr-microbiom
Rwyf hefyd yn ymchwilio i rôl microbiom y perfedd mewn iechyd a chlefydau. Trwy ddadansoddi llofnodion microbaidd, rydym yn anelu at ddeall yn well y cysylltiadau rhwng cyfansoddiad microbiom ac iechyd systemig. Rydym yn cymhwyso'r wybodaeth hon i drin microbiom y perfedd gan ddefnyddio ymyriadau wedi'u targedu fel probiotigau a gwrthfiotigau, gyda'r nod o wella canlyniadau iechyd ac archwilio strategaethau therapiwtig newydd.
Canfod a monitro bioluminescence morol o bell
Y tu hwnt i'r labordy, rwy'n archwilio technolegau canfod o bell, gyda diddordeb arbennig mewn monitro bioluminescence morol. Mae'r gwaith hwn yn cyfuno delweddau lloeren, data amgylcheddol a gwyddoniaeth dinasyddion i olrhain gweithgaredd microbaidd mewn ecosystemau cefnfor, gan gynnig ffyrdd newydd o astudio dynameg microbaidd ar raddfa. Trwy integreiddio arsylwadau cyhoeddus â thechnegau delweddu uwch, rydym yn anelu at ddatblygu offer rhagfynegol sy'n gallu canfod digwyddiadau bioluminescent, deall yr amodau amgylcheddol sy'n eu gyrru a rhagfynegi effeithiau newid yn yr hinsawdd. Mae'r dull hwn nid yn unig yn gwella ein gallu i fonitro prosesau microbaidd mewn amser real ond hefyd yn ymgysylltu â chymunedau mewn darganfyddiadau gwyddonol, pontio microbioleg â gwyddoniaeth amgylcheddol, dadansoddeg data ac ymgysylltu â'r cyhoedd.
Addysgu
Rwy'n Ddarlithydd Microbioleg sy'n dysgu ar y cyrsiau canlynol:
- BI1001 Sgiliau ar gyfer Gwyddoniaeth: Ymarferol ar Dechnegau Aseptig
- BI1051 Geneteg ac Esblygiad: Ymarferol ar drosglwyddo genynnau bacteriol.
- BI2332 Cysyniadau Clefyd: Microbiome perfedd ac ymarferol ar Achosion o Heintiau.
- BI3155 Bioleg ac Epidemioleg Heintiau: Virulence bacteriol.
- BI3001 Prosiect Blwyddyn Olaf: Prosiectau Labordy a Llenyddiaeth.
- BI4001 Prosiect Ymchwil Uwch (Meistr Integredig)
- BIT014 Prosiect Ymarferol yn y Biowyddorau (MRes)
- Prosiect Ymchwil BIT054 (MSc Ecoleg a Chadwraeth Byd-eang)
Rwyf hefyd wedi darlithio gwadd ym Mhrifysgol Metropolitan Caerdydd, am y drydedd flwyddyn Gwyddor Gofal Iechyd ac MSc mewn Iechyd Cyhoeddus Cymhwysol, yn ogystal â'r modiwl Electroneg Feddygol Blwyddyn 3 yn Ysgol Peirianneg Prifysgol Caerdydd.
Rwy'n Gymrawd o'r Academi Addysg Uwch.
Rwyf wedi goruchwylio >30 o fyfyrwyr israddedig, ôl-raddedig a lleoliad haf yn eu prosiectau labordy ac rwyf hefyd yn oruchwyliwr ar dair ysgoloriaeth PhD rhyngddisgyblaethol gydag Ysgolion Peirianneg, Cemeg a Fferylliaeth Caerdydd.
Bywgraffiad
Anrhydeddau a dyfarniadau
Wedi'i ddewis fel un o 50 Menywod Gorau mewn Peirianneg y Telegraph, 2017
Wedi'i ddewis fel un o 35 o fenywod busnes a phroffesiynol ifanc gorau Wales Online dan 35 oed, 2017
Dyfarnwyd gwobr 1af am bosteri / cyflwyniadau llafar mewn cynadleddau cenedlaethol amrywiol
Dyfarnwyd Tystysgrif Canmoliaeth i draethawd PhD gan Gymdeithas Sŵolegol Llundain am wobr Thomas Henry Huxley, 2013
Aelodaethau proffesiynol
Cymrawd yr Academi Addysg Uwch (cyfredol)
Cymdeithas Microbioleg (cyfredol)
Microbioleg Gymhwysol Ryngwladol (cyfredol)
Cymdeithas Peirianneg Menywod (2018)
Sefydliad y Peirianwyr Trydanol ac Electroneg (2018)
Safleoedd academaidd blaenorol
Darlithydd mewn Microbioleg, Ysgol y Biowyddorau Caerdydd: Medi 2021 - presennol
Absenoldeb Mamolaeth 2: Awst 2022 - Awst 2023
Absenoldeb Mamolaeth 1: Tachwedd 2018 - Tachwedd 2019
Cydymaith Ymchwil MRC, Ysgol Deintyddiaeth Caerdydd: Mawrth 2021 - Awst 2021
Cymrawd Ymchwil Sêr Cymru II, Ysgol Peirianneg Caerdydd: Rhagfyr 2016 – Chwefror 2021
Cydymaith Ymchwil Ôl-ddoethurol Sêr Cymru (NRN), Ysgolion Biowyddoniaeth a Pheirianneg Caerdydd: Rhagfyr 2014 - Tachwedd 2016
Cydymaith Ymchwil Ôl-ddoethurol KTP, Cultech Ltd. a Phrifysgol Reading: Mehefin 2013 - Tachwedd 2014
PhD, Prifysgol Caerdydd: Hydref 2009 - Mai 2013
Ysgolion Biowyddoniaeth a Chemeg, Prifysgol Caerdydd a Neem Biotech Ltd. (EPSRC)
Ymrwymiadau siarad cyhoeddus
Williams CF et al. (2024). Microdonnau mewn meddygaeth: hanes, cyfle a heriau. Cyfarfod Gwyddoniaeth Microdon mewn Cynaliadwyedd, Y Gymdeithas Frenhinol, Llundain, 13-14 Mai 2024.
Williams CF et al. (2017 a 2018). Mae maes trydanol microdon yn 2.45 GHz yn modiwleiddio ymateb β-adrenergig cardiomyocytau sy'n deillio o fôn-gelloedd embryonig dynol. Gŵyl Ymchwil Sêr Cymru, 2 Hydref 2017 a Chynhadledd Ryngwladol Bioelectromagneteg (BioEM), Slofenia, 25-29 Mehefin 2018.
Williams CF et al. (2017). Effeithiau biomoleciwlaidd sy'n sail i ymatebion cellog nad ydynt yn thermol i feysydd trydanol amledd microdon. Symposiwm Microdon Rhyngwladol, Honolulu, 4-9 Mehefin 2017.
Williams CF et al. (2016). Beth all y môr dwfn ei ddweud wrthym am microdonnau. Symposiwm Microdon Rhyngwladol, San Francisco, 22-27 Mai 2016.
Williams CF et al. (2011). Effeithiau atalyddion ar ddeinameg redox Spironucleus vortens. Cyfarfod Plant-Micro Cymru, Bangor, 11-12 Gorffennaf, 2011 a Chyngres Ewropeaidd y Protisolegwyr (ECOP), Berlin, 25-29 Gorffennaf, 2011.
Williams CF et al. (2010). Garlleg: iachâd posibl ar gyfer clefyd 'twll yn y pen' mewn pysgod? Cyfarfod Plant-Micro Cymru, Aberystwyth, 12-13 Gorffennaf, 2010 a Chymdeithas Ryngwladol y Protisolegwyr (ISOP), Caergaint, 18-23 Gorffennaf, 2010.
Pwyllgorau ac adolygu
Aelod o Bwyllgor Llywio Rhwydwaith Cynghrair Gwrthficrobaidd GW4+
Mentor ECR ar gyfer Rhwydwaith Cynghrair Gwrthficrobaidd GW4+
Golygydd Adolygu ar gyfer Frontiers in Microbiology, 2015-presennol
Golygydd Adolygu ar gyfer Frontiers in Physiology, 2015-2022
Aelod o banel Fforwm Gyrfa Gynnar Peirianneg EPSRC, 2018-2022
Meysydd goruchwyliaeth
Ar hyn o bryd rwy'n goruchwylio'r myfyrwyr canlynol
- Lily Hannan, Meistr Integredig - Cymwysiadau biofeddygol microdonnau
- Shivangi Shukla (Ysgol Peirianneg a Biowyddorau), ymgeisydd PhD - microSENSE: System Canfod Cyflym a Sensitif ar gyfer Pathogenau Milheintiau
- Caitlin Bellamy (Ysgol Fferylliaeth a Biowyddorau), ymgeisydd PhD - Sianeli protein pilen peirianneg ar gyfer cyflenwi cyffuriau biolegol o gelloedd artiffisial
Prosiectau'r gorffennol
- Jude Humphreys (Schoo of Biosciences, Meistr Integredig: Ch
- Angharad Miles (Ysgol Peirianneg): Rhyngweithiadau sylfaenol celloedd â meysydd electromagnetig (ymgeisydd PhD)
- Charlotte Morgan (Ysgol y Biowyddorau): Ymchwilio i botensial therapiwtig microdonnau mewn iachau clwyfau (MRes)
- Božo Lugonja (Ysgol y Biowyddorau): Triniaethau Dŵr Newydd ar gyfer y Pathogen Zoonotig a gludir gan y Dŵr Cryptosporidium (ymgeisydd PhD)
Ymgysylltu
ArrayContact Details
+44 29208 74595
Adeilad Syr Martin Evans, Ystafell W/2.12, Rhodfa'r Amgueddfa, Caerdydd, CF10 3AX
Themâu ymchwil
Arbenigeddau
- Microbioleg
- ymwrthedd gwrthficrobaidd
- Gwyddoniaeth microbiome gwlyb
- Microsgopeg
- Diagnosteg biotechnoleg meddygol
