Yr Athro Susan Wong

2024

• Bessard, M. et al. 2024. Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes. Frontiers in Immunology 15, article number: 1474453. (10.3389/fimmu.2024.1474453)
• Kakabadse, D. et al. 2024. Regulatory CD4 + T cells redirected against pathogenic CD8 + T cells protect NOD mice from development of autoimmune diabetes. Frontiers in Immunology 15, article number: 1463971. (10.3389/fimmu.2024.1463971)
• Smith, M. J., Boldison, J. and Wong, F. S. 2024. The role of B lymphocytes in type 1 diabetes. Cold Spring Harbor Perspectives in Medicine (10.1101/cshperspect.a041593)
• Yang, X. et al. 2024. Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10 + Breg cells and protect against T1D. Frontiers in Immunology 15, article number: 1413177. (10.3389/fimmu.2024.1413177)
• Wang, P. et al. 2024. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 15(1), article number: 4232. (10.1038/s41467-024-48611-8)
• Zhang, L., Wang, P., Huang, J., Xing, Y., Wong, F. S., Suo, J. and Wen, L. 2024. Gut microbiota and therapy for obesity and type 2 diabetes. Frontiers in Endocrinology 15, article number: 1333778. (10.3389/fendo.2024.1333778)
• Pearson, J. A., Hu, Y., Peng, J., Wong, F. S. and Wen, L. 2024. TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model. Frontiers in Immunology 15, article number: 1333967. (10.3389/fimmu.2024.1333967)

2023

• Hanna, S. J. et al. 2023. Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans. Frontiers in Immunology 14, article number: 1276255. (10.3389/fimmu.2023.1276255)
• Pearson, J. A. et al. 2023. NLRP6 deficiency expands a novel CD103 + B cell population that confers immune tolerance in NOD mice. Frontiers in Immunology 14, article number: 1147925. (10.3389/fimmu.2023.1147925)
• Okada, M. et al. 2023. Islet‐specific CD8+ T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry. Immunology & Cell Biology 101(1), pp. 36-48. (10.1111/imcb.12593)

2022

• Pearson, J. A. et al. 2022. IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans. Diabetologia 65(8), pp. 1398-1411. (10.1007/s00125-022-05711-8)
• Chan, K., Wong, F. S. and Pearson, J. A. 2022. Circadian rhythms and pancreas physiology: A review. Frontiers in Endocrinology 13, article number: 920261. (10.3389/fendo.2022.920261)
• Majewska-Szczepanik, M. et al. 2022. Obesity aggravates contact hypersensitivity reaction in mice. Contact Dermatitis 87(1), pp. 28-39. (10.1111/cod.14088)
• Jia, J., Kang, Q., Liu, S., Song, Y., Wong, F. S., Qiu, Y. and Li, M. 2022. Artemether and aspterric acid induce pancreatic alpha cells to transdifferentiate into beta cells in zebrafish. British Journal of Pharmacology 179(9), pp. 1962-1977. (10.1111/bph.15769)
• Green, E. A., Cooke, A. C., Piganelli, J. D., Richardson, S. J., Wen, L. and Wong, F. S. 2022. Editorial: Immunopathology of Type 1 Diabetes. Frontiers in Immunology 13, article number: 852963. (10.3389/fimmu.2022.852963)
• Boldison, J. et al. 2022. Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes. Diabetologia 65, article number: 343–355. (10.1007/s00125-021-05595-0)
• Huang, J., Pearson, J. A., Wong, F. S., Wen, L. and Zhou, Z. 2022. Innate immunity in latent autoimmune diabetes in adults (LADA). Diabetes/Metabolism Research and Reviews 38(1), article number: e3480. (10.1002/dmrr.3480)
• Roy Chowdhury, S., Thomas, R. L., Dunseath, G. J., Luzio, S. D., Wong, F. S. and Owens, D. R. 2022. Incidence of diabetic retinopathy in newly diagnosed subjects with type 2 diabetes mellitus over 5 years: Contribution of B-cell function. Journal of Diabetes and its Complications 36(1), article number: 108028. (10.1016/j.jdiacomp.2021.108028)
• Tatovic, D. et al. 2022. Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in Type 1 diabetes. Immunotherapy Advances 2(1), article number: ltac002. (10.1093/immadv/ltac002)
• Buzzetti, R., Maddaloni, E., Gaglia, J. G., Leslie, R. D., Wong, F. S. and Boehm, B. O. 2022. Adult-onset autoimmune diabetes. Nature Reviews Disease Primers 8, article number: 63. (10.1038/s41572-022-00390-6)

2021

• Quinn, L. M., Wong, F. S. and Narendran, P. 2021. Environmental determinants of type 1 diabetes: from association to proving causality. Frontiers in Immunology 12, article number: 737964. (10.3389/fimmu.2021.737964)
• Boldison, J. and Wong, F. S. 2021. Regulatory B cells: role in type 1 diabetes. Frontiers in Immunology 12, article number: 746187. (10.3389/fimmu.2021.746187)
• Pearson, J. A., Voisey, A. C., Boest Bjerg, K., Wong, F. S. and Wen, L. 2021. Circadian rhythm modulation of microbes during health and infection. Frontiers in Microbiology 12, article number: 721004. (10.3389/fmicb.2021.721004)
• Huang, J. et al. 2021. IL-10 deficiency accelerates type 1 diabetes development via modulation of innate and adaptive immune cells and gut microbiota in BDC2.5 NOD mice. Frontiers in Immunology 12, article number: 702955. (10.3389/fimmu.2021.702955)
• Pearson, J. A., Wong, F. S. and Wen, L. 2021. Inflammasomes and type 1 diabetes. Frontiers in Immunology 12, article number: 686956. (10.3389/fimmu.2021.686956)
• Siah, Q. Z., Ubeysekara, N. H., Taylor, P. N., Davies, S. J., Wong, F., Dayan, C. M. and Alhadj Ali, M. 2021. Referral rates of patients with diabetes to secondary care are inversely related to the prevalence of diabetes in each primary care practice and confidence in treatment, not to HbA1c level. Primary Care Diabetes 15(3), pp. 513-517. (10.1016/j.pcd.2021.02.004)
• Battaglia, M., Buckner, J. H., Levings, M. K., Richardson, S. J., Wong, F. S. and Tree, T. I. 2021. Identifying the ‘Achilles heel’ of type 1 diabetes. Clinical and Experimental Immunology 204(2), pp. 167-178. (10.1111/cei.13570)
• Wong, F. S. and Tree, T. I. 2021. Historical and new insights into pathogenesis of type 1 diabetes (2). Clinical and Experimental Immunology 204(2), pp. 165-166. (10.1111/cei.13597)
• Boldison, J., Thayer, T. C., Davies, J. and Wong, F. S. 2021. Natural protection from Type 1 Diabetes in Non obese diabetic (Nod) mice is characterised by a unique pancreatic islet phenotype. Diabetes 70(3), article number: db200945. (10.2337/db20-0945)
• Thayer, T. C., Davies, J., Pearson, J. A., Hanna, S. J., Wen, L. and Wong, F. S. 2021. Differentiating MHC-dependent and -independent mechanisms of lymph node stromal cell regulation of Proinsulin-specific CD8+ T-Cells in type 1 diabetes. Diabetes 70(2), pp. 529-537., article number: db191050. (10.2337/db19-1050)
• Singh, R. K. et al. 2021. Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides. Nanomedicine: Nanotechnology, Biology and Medicine 32, article number: 102321. (10.1016/j.nano.2020.102321)
• Huang, J. et al. 2021. Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular and Molecular Immunology 18, pp. 328-338. (10.1038/s41423-020-00590-8)
• Sha, S. et al. 2021. TLR9-deficiency in B cells promotes immune tolerance via IL-10 in a type 1 diabetes mouse model. Diabetes 70(2), pp. 504-515. (10.2337/db20-0373)
• Boldison, J., Da Rosa, L. C. and Wong, F. S. 2021. Regulatory B cells in type 1 diabetes. In: Mion, F. and Tonon, S. eds. Regulatory B Cells., Vol. 2270. Methods in Molecular Biology New York, US: Humana Press, pp. 419-435., (10.1007/978-1-0716-1237-8_22)

2020

• Pearson, J. A., Wong, F. S. and Wen, L. 2020. Crosstalk between circadian rhythms and the microbiota. Immunology 161(4), pp. 278-290. (10.1111/imm.13278)
• Pearson, J. A. et al. 2020. Insulin-reactive T cells convert diabetogenic insulin-reactive VH125 B cells into tolerogenic cells by reducing germinal center T:B cell Interactions in NOD mice. Frontiers in Immunology 11, article number: 585886. (10.3389/fimmu.2020.585886)
• Huang, J. et al. 2020. Altered systemic and intestinal IgA immune responses in individuals with type 1 diabetes. Journal of Clinical Endocrinology and Metabolism 105(12), article number: dgaa590. (10.1210/clinem/dgaa590)
• Boldison, J., Camargo Da Rosa, L., Davies, J., Wen, L. and Wong, F. S. 2020. Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells. Cellular and Molecular Immunology 17, pp. 843 - 855. (10.1038/s41423-019-0324-z)
• Hanna, S. J. et al. 2020. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype. Diabetologia 63, pp. 1174-1185., article number: Diabetologia volume 63, pages1174–1185(2020). (10.1007/s00125-020-05114-7)
• Arikat, F. et al. 2020. Targeting proinsulin to local immune cells using an intradermal microneedle delivery system; a potential antigen-specific immunotherapy for type 1 diabetes. Journal of Controlled Release 322, pp. 593-601. (10.1016/j.jconrel.2020.02.031)
• Huang, J. et al. 2020. Gut microbial metabolites alter IgA immunity in type 1 diabetes. JCI Insight 5(10), article number: e135718. (10.1172/jci.insight.135718)
• Wong, F. S. and Wen, L. 2020. A predictive CD8+ T cell phenotype for T1DM progression. Nature Reviews Endocrinology 16, pp. 198-199. (10.1038/s41574-020-0330-3)
• Thayer, T. C., Kakabadse, D., Boldison, J. and Wong, F. S. 2020. Assessing immune responses in the nonobese diabetic mouse model of type 1 Diabetes. In: Animal Models of Diabetes., Vol. 2128. Methods in Molecular Biology New York, NY, USA: Humana Press, pp. 269-289., (10.1007/978-1-0716-0385-7_18)
• Chen, D., Thayer, T. C., Wen, L. and Wong, F. S. 2020. Mouse models of autoimmune diabetes: the nonobese diabetic (NOD) mouse. In: Animal Models of Diabetes., Vol. 2128. Methods in Molecular Biology New York, NY, USA: Humana Press, pp. 87-92., (10.1007/978-1-0716-0385-7_6)

2019

• Wong, F. S. and Tree, T. I. 2019. Historical and new insights into pathogenesis of type 1 diabetes. Clinical and Experimental Immunology 198(3), pp. 292-293. (10.1111/cei.13396)
• Boldison, J., Da Rosa, L. C., Buckingham, L., Davies, J., Wen, L. and Wong, F. S. 2019. Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice. Diabetologia 62(11), pp. 2052-2065. (10.1007/s00125-019-04974-y)
• Pearson, J. A. et al. 2019. Norovirus changes susceptibility to type 1 diabetes by altering intestinal microbiota and immune cell functions. Frontiers in Immunology 10, article number: 2654. (10.3389/fimmu.2019.02654)
• Choudhury, M. et al. 2019. Association between HbA1c and the development of cystic fibrosis‐related diabetes. Diabetic Medicine 36(10), pp. 1251-1255. (10.1111/dme.13912)
• Powell, W. et al. 2019. Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot. Journal of Immunological Methods 471, pp. 61-65. (10.1016/j.jim.2019.05.007)
• Pearson, J. A. et al. 2019. Altered gut microbiota activate and expand insulin B15-23-Reactive CD8+ T-Cells. Diabetes 68(5), pp. 1002-1013. (10.2337/db18-0487)
• Dul, M. et al. 2019. Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy. International Journal of Pharmaceutics 562, pp. 303-312. (10.1016/j.ijpharm.2019.03.041)

2018

• Liu, M. et al. 2018. Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes. Diabetologia 61(11), pp. 2333-2343. (10.1007/s00125-018-4705-0)
• Hu, Y., Peng, J., Li, F., Wong, F. and Wen, L. 2018. Evaluation of different mucosal microbiota leads to gut microbiota-based prediction of type 1 diabetes in NOD mice. Scientific Reports 8 (10.1038/s41598-018-33571-z)
• Szczepanik, M., Majewska-Szczepanik, M., Wong, F. S., Kowalczyk, P., Pasare, C. and Wen, L. 2018. Regulation of contact sensitivity in non-obese diabetic (NOD) mice by innate immunity. Contact Dermatitis 79(4), pp. 197. (10.1111/cod.13046)
• Pearson, J. A., Agriantonis, A., Wong, F. S. and Wen, L. 2018. Modulation of the immune system by the gut microbiota in the development of type 1 diabetes. Human Vaccines and Immunotherapeutics 14(11), pp. 2580-2596. (10.1080/21645515.2018.1514354)
• Gülden, E. et al. 2018. TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells. Journal of Autoimmunity 93, pp. 57-65. (10.1016/j.jaut.2018.06.003)
• Powell, W. E. et al. 2018. Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes. Diabetologia 61, pp. 1794-1803. (10.1007/s00125-018-4651-x)
• Long, A. E. et al. 2018. Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study. Diabetologia 61(6), pp. 1484-1490. (10.1007/s00125-018-4591-5)
• Da Rosa, L. C., Boldison, J., De Leenheer, E., Davies, J., Wen, L. and Wong, F. S. 2018. B cell depletion reduces T cell activation in pancreatic islets in a murine autoimmune diabetes model. Diabetologia 61(6), pp. 1397-1410. (10.1007/s00125-018-4597-z)
• James, E. A. et al. 2018. Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop. Diabetologia 61(3), pp. 658-670. (10.1007/s00125-017-4508-8)
• Tan, Q. et al. 2018. Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice. JCI Insight 3(1), article number: 95882. (10.1172/jci.insight.95882)

2017

• Dul, M. et al. 2017. Hydrodynamic gene delivery in human skin using a hollow microneedle device. Journal of Controlled Release 265, pp. 120-131. (10.1016/j.jconrel.2017.02.028)
• Zhao, X., Coulman, S. A., Hanna, S. J., Wong, F. S., Dayan, C. M. and Birchall, J. C. 2017. Formulation of hydrophobic peptides for skin delivery via coated microneedles. Journal of Controlled Release 265, pp. 2-13. (10.1016/j.jconrel.2017.03.015)
• Reeves, P. L., Rudraraju, R., Liu, X., Wong, F. S., Hamilton-Williams, E. E. and Steptoe, R. J. 2017. APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice. Immunology and Cell Biology 95(9), pp. 765-774. (10.1038/icb.2017.48)
• Reeves, P., Rudraraju, R., Wong, F., Hamilton-Williams, E. and Steptoe, R. 2017. Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8(+) T-cell priming to tolerance in autoimmune-prone NOD mice. European Journal of Immunology 47(9), pp. 1550-1561. (10.1002/eji.201747089)
• Recino, A., Barkan, K., Wong, F. S., Ladds, G., Cooke, A. and Wallberg, M. 2017. Hyperglycaemia does not affect antigen-specific activation and cytolytic killing by CD8+ T cells in vivo. Bioscience Reports 37(4), article number: 1079. (10.1042/BSR20171079)
• Alhadj Ali, M. et al. 2017. Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes. Science Translational Medicine 9(402), article number: eaaf7779. (10.1126/scitranslmed.aaf7779)
• Li, Y. Y. et al. 2017. Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota. Journal of Autoimmunity 82, pp. 85-95. (10.1016/j.jaut.2017.05.007)
• Wen, L. and Wong, F. 2017. Dietary short chain fatty acids protect against type 1 diabetes. Nature Immunology 18(5), pp. 484-486. (10.1038/ni.3730)
• Wallberg, M. et al. 2017. Anti-CD3 treatment up-regulates programmed cell death protein-1 expression on activated effector T cells and severely impairs their inflammatory capacity. Immunology 151(2), pp. 248-260. (10.1111/imm.12729)
• Fishman, S. et al. 2017. Adoptive transfer of mRNA-Transfected T cells redirected against diabetogenic CD8 T cells can prevent diabetes. Molecular Therapy 25(2), pp. 456-464. (10.1016/j.ymthe.2016.12.007)
• Hu, Y., Wong, F. S. and Wen, L. 2017. Antibiotics, gut microbiota, environment in early life and type 1 diabetes. Pharmacological Research 119, pp. 219-226. (10.1016/j.phrs.2017.01.034)

2016

• Boldison, J. and Wong, F. S. 2016. Immune and pancreatic β cell interactions in type 1 diabetes. Trends in Endocrinology & Metabolism 27(12), pp. 856-867. (10.1016/j.tem.2016.08.007)
• Williams, G. M. et al. 2016. Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes. Diabetologia 59(12), pp. 2722-2726. (10.1007/s00125-016-4087-0)
• Thayer, T. C. et al. 2016. Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T Cells in type 1 diabetes. Diabetes 65(11), pp. 3429-3439. (10.2337/db15-1649)
• Clement, M. et al. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6, article number: 35332. (10.1038/srep35332)
• Tai, N. et al. 2016. Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice. Journal of Experimental Medicine 213(10), pp. 2129. (10.1084/jem.20160526)
• Hu, Y., Jin, P., Peng, J., Zhang, X., Wong, F. S. and Wen, L. 2016. Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice. Journal of Autoimmunity 72, pp. 47-56. (10.1016/j.jaut.2016.05.001)
• Tai, N., Wong, F. S. and Wen, L. 2016. The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes. Journal of Autoimmunity 71, pp. 26-34. (10.1016/j.jaut.2016.03.006)
• Thayer, T. C. and Wong, F. S. 2016. Tracking immunological responses of Islet antigen-specific T cells in the Nonobese Diabetic (NOD) Mouse Model of Type 1 Diabetes. In: Gillespie, K. ed. Type-1 Diabetes: Methods and Protocols., Vol. 1433. Methods in Molecular Biology Humana Press, New York, NY, pp. 127-134., (10.1007/7651_2015_293)
• De Leenheer, E. and Wong, F. S. 2016. Adoptive transfer of autoimmune diabetes using immunodeficient Non Obese Diabetic (NOD) mice. In: Gillespie, K. M. ed. Type-1 Diabetes: Methods and Protocols., Vol. 1433. Methods in Molecular Biology Humana Press, New York, NY, pp. 135-140., (10.1007/7651_2015_294)
• Pearson, J. A. et al. 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65(6), pp. 1679-1689. (10.2337/db15-1498)
• Peng, J., Hu, Y., Wong, F. S. and Wen, L. 2016. The gut microbiome in the NOD mouse. In: Gillespie, K. M. ed. Type-1 Diabetes: Methods and Protocols., Vol. 1433. Methods in Molecular Biology Vol. 1433. Springer, pp. 169-177., (10.1007/7651_2016_331)
• Zhao, X. et al. 2016. Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes. Journal of Controlled Release 223, pp. 178-187. (10.1016/j.jconrel.2015.12.040)
• Pearson, J. A., Wong, F. S. and Wen, L. 2016. The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes. Journal of Autoimmunity 66, pp. 76-88. (10.1016/j.jaut.2015.08.019)
• Barbera Betancourt, A., Emery, J. L., Recino, A., Wong, F. S., Cooke, A., Okkenhaug, K. and Wallberg, M. 2016. Inhibition of phosphoinositide 3-Kinase p110delta does not affect T cell driven development of Type 1 diabetes despite significant effects on cytokine production. PLoS ONE 11(1), article number: e0146516. (10.1371/journal.pone.0146516)

2015

• Pearson, J. A. and Wong, F. S. 2015. Identification of islet antigen-specific CD8 T cells using MHCI-peptide tetramer reagents in the non obese diabetic (NOD) mouse model of type 1 diabetes. In: Gillespie, K. M. ed. Type-1 Diabetes., Vol. 1433. Methods in Molecular Biology Springer, pp. 119-125., (10.1007/7651_2015_295)
• Alhadj Ali, M. et al. 2015. Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin. Immunology 146(3), pp. 411-422. (10.1111/imm.12518)
• Hu, Y., Peng, J., Tai, N., Hu, C., Zhang, X., Wong, F. S. and Wen, L. 2015. Maternal antibiotic treatment protects offspring from diabetes development in nonobese diabetic mice by generation of tolerogenic APCs. Journal of Immunology 195(9), pp. 4176-4184. (10.4049/jimmunol.1500884)
• Culina, S. et al. 2015. Materno-Fetal transfer of preproinsulin through the neonatal FC receptor prevents autoimmune diabetes. Diabetes 64(10), pp. 3532-3542. (10.2337/db15-0024)
• Hu, C. et al. 2015. NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets. Proceedings of the National Academy of Sciences 112(36), pp. 11318-11323. (10.1073/pnas.1513509112)
• Gülden, E., Wong, F. S. and Wen, L. 2015. The gut microbiota and Type 1 Diabetes. Clinical Immunology 159(2), pp. 143-153. (10.1016/j.clim.2015.05.013)
• Motozono, C. et al. 2015. Distortion of the major histocompatibility complex class I binding groove to accommodate an insulin-derived 10-Mer peptide. Journal of Biological Chemistry 290(31), pp. 18924-18933. (10.1074/jbc.M114.622522)
• Tatovic, D., Young, P., Kochba, E., Levin, Y., Wong, F. S. and Dayan, C. M. 2015. Fine-needle aspiration biopsy of the lymph node: a novel tool for the monitoring of immune responses after skin antigen delivery. Journal of Immunology 195(1), pp. 386-392. (10.4049/jimmunol.1500364)
• Sayers, A. et al. 2015. Evidence for a persistent, major excess in all cause admissions to hospital in children with type-1 diabetes: results from a large Welsh national matched community cohort study. BMJ Open 5, article number: e005644. (10.1136/bmjopen-2014-005644)
• Tai, N., Wong, F. S. and Wen, L. 2015. The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity. Reviews in Endocrine and Metabolic Disorders 16(1), pp. 55-65. (10.1007/s11154-015-9309-0)
• Lewis, M. D., de Leenheer, E., Fishman, S., Siew, L. K., Gross, G. and Wong, F. S. 2015. A reproducible method for the expansion of mouse CD8+ T lymphocytes. Journal of Immunological Methods 417, pp. 134-138. (10.1016/j.jim.2015.01.004)

2014

• Kleffel, S. et al. 2014. Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+B cells to maintain tolerance to islet autoantigens. Diabetes 64(1), pp. 158-171. (10.2337/db13-1639)
• Pearson, J., Thayer, T. C., McLaren, J. E., Miners, K. L., Ladell, K. I., Price, D. and Wong, F. S. 2014. Analysis of the repertoire of insulin-reactive CD8(+) T cells [Abstract]. Immunology 143(S2), pp. 152-152. (10.1111/imm.12406)
• Perez, S., Fishman, S., Bordowitz, A., Margalit, A., Wong, F. and Gross, G. 2014. Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells. Immunology 143(4), pp. 609-617. (10.1111/imm.12340)
• Yüksel, M. et al. 2014. Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis. International Journal of Experimental Pathology 95(5), pp. 309-320. (10.1111/iep.12090)
• Peng, J., Narasimhan, S., Marchesi, J. R., Benson, A., Wong, F. S. and Wen, L. 2014. Long term effect of gut microbiota transfer on diabetes development. Journal of Autoimmunity 53, pp. 85-94. (10.1016/j.jaut.2014.03.005)
• Tan, Q., Majewska-Szczepanik, M., Zhang, X., Szczepanik, M., Zhou, Z., Wong, F. S. and Wen, L. 2014. IRAK-M deficiency promotes the development of type 1 diabetes in NOD mice. Diabetes 63(8), pp. 2761-2775. (10.2337/db13-1504)
• Hsu, H. et al. 2014. Endoplasmic reticulum targeting alters regulation of expression and antigen presentation of proinsulin. The Journal of Immunology 192(11), pp. 4957-4966. (10.4049/jimmunol.1300631)
• Wong, F. 2014. How does B-Cell tolerance contribute to the protective effects of diabetes following induced mixed chimerism in autoimmune diabetes?. Diabetes 63(6), pp. 1855-1857. (10.2337/db14-0327)

2013

• Thomas, D. C., Wong, F. S., Zaccone, P., Green, E. A. and Wallberg, M. 2013. Protection of Islet Grafts through transforming growth factor-β–induced Tolerogenic Dendritic cells. Diabetes 62(9), pp. 3132-3142. (10.2337/db12-1740)
• Tai, N., Wong, F. S. and Wen, L. 2013. TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice. The Journal of Immunology 191(6), pp. 2926-2937. (10.4049/jimmunol.1300547)
• Hu, C., Ding, H., Zhang, X., Wong, F. and Wen, L. 2013. Combination treatment with Anti-CD20 and oral Anti-CD3 prevents and reverses autoimmune diabetes. Diabetes 62(8), pp. 2849-2858. (10.2337/db12-1175)
• Wong, F. S. and Wen, L. 2013. Therapy: Immunotherapy for T1DM—targeting innate immunity. Nature Reviews Endocrinology 9(7), pp. 384-385. (10.1038/nrendo.2013.103)

2012

• Alhadj Ali, M., Hanna, S., Wong, S. and Dayan, C. 2012. Functional modulation of epidermal dendritic cells by topical steroid treatment to optimise the tolerogenic potential of immunotherapy for type 1 diabetes [Abstract]. Diabetologia 55(S1), pp. S192. (10.1007/s00125-012-2688-9)
• Dong, B. et al. 2012. TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes. American Journal of Physiology - Heart and Circulatory Physiology 303(6), pp. H732-H742. (10.1152/ajpheart.00948.2011)
• Xiang, Y., Peng, J., Tai, N., Hu, C., Zhou, Z., Wong, F. S. and Wen, L. 2012. The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice. The Journal of Immunology 188(10), pp. 4747-4758. (10.4049/jimmunol.1103055)
• Hu, C., Du, W., Zhang, X., Wong, F. S. and Wen, L. 2012. The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic mice. The Journal of Immunology 188(1), pp. 294-301. (10.4049/jimmunol.1101590)
• Wong, F. S. and Wen, L. 2012. Type 1 diabetes therapy beyond T cell targeting: Monocytes, B cells, and innate lymphocytes. The Review of Diabetic Studies 9(4), pp. 289-304. (10.1900/RDS.2012.9.289)

2011

• Alhadj Ali, M., Thrower, S., Harris, S., Wong, S. and Dayan, C. 2011. Optimizing the tolerogenic potential of a 'vaccine' for type 1 diabetes by topical betamethasone therapy [Abstract]. Diabetologia 54(S1), pp. S88-S89. (10.1007/s00125-011-2276-4)
• Tai, N. et al. 2011. IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice. Clinical Immunology 139(3), pp. 336-349. (10.1016/j.clim.2011.03.003)
• Alhadj Ali, M., Thrower, S., Harris, S., Wong, S. and Dayan, C. 2011. Effects of topical steroid and vitamin D therapy in optimizing the tolerogenic potential of a 'vaccine' for type 1 diabetes. Diabetic Medicine 28(S1), pp. 80. (10.1111/j.1464-5491.2011.03233_1.x)
• Wallberg, M., Wong, F. S. and Green, E. A. 2011. An islet-specific pulse of TGF-abrogates CTL function and promotes cell survival independent of Foxp3+ T cells. Journal of Immunology 186(4), pp. 2543-2551. (10.4049/jimmunol.1002098)
• Wong, F. S. 2011. Stimulating IL-13 receptors on T cells: a new pathway for tolerance induction in diabetes?. Diabetes 60(6), pp. 1657-1659. (10.2337/db11-0353)
• Oresic, M. et al. 2011. T cells recognizing a peptide contaminant undetectable by mass spectrometry. PLoS ONE 6(12), article number: e28866. (10.1371/journal.pone.0028866)
• Mallone, R. et al. 2011. Immunology of diabetes society T-Cell workshop: HLA class I tetramer-directed epitope validation initiative T-Cell workshop report-HLA class I tetramer validation initiative. Diabetes/Metabolism Research and Reviews 27(8), pp. 720-726. (10.1002/dmrr.1243)
• Mehers, K. L. et al. 2011. An increased frequency of NK cell receptor and HLA-C group 1 combinations in early-onset type 1 diabetes. Diabetologia 54(12), pp. 3062-3070. (10.1007/s00125-011-2299-x)
• Mallone, R., Mannering, S. I., Brooks-Worrell, B. M., Durinovic-Belló, I., Cilio, C. M., Wong, F. S. and Schloot, N. C. 2011. Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society. Clinical and Experimental Immunology 163(1), pp. 33-49. (10.1111/j.1365-2249.2010.04272.x)

2010

• Scott, G. S. et al. 2010. Immunotargeting of insulin reactive CD8 T cells to prevent diabetes. Journal of Autoimmunity 35(4), pp. 390-397. (10.1016/j.jaut.2010.08.005)
• Petrich de Marquesini, L. G. et al. 2010. IFN-γ and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes. Diabetologia 53(7), pp. 1451-1460. (10.1007/s00125-010-1739-3)
• Wong, F. S., Hu, C., Xiang, Y. and Wen, L. 2010. To B or not to B - pathogenic and regulatory B cells in autoimmune diabetes. Current Opinion in Immunology 22(6), pp. 723-731. (10.1016/j.coi.2010.10.002)
• Mannering, S. I. et al. 2010. Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes. Clinical and Experimental Immunology 162(2), pp. 197-209. (10.1111/j.1365-2249.2010.04237.x)
• Sequeiros, I. M. et al. 2010. MRI appearance of the pancreas in patients with cystic fibrosis: A comparison of pancreas volume in diabetic and non-diabetic patients. British Journal of Radiology 83(995), pp. 921-926. (10.1259/bjr/24009651)
• Colonna, L. et al. 2010. Therapeutic targeting of syk in autoimmune diabetes. The Journal of Immunology 185(3), pp. 1532-1543. (10.4049/jimmunol.1000983)
• Jarad, N. A. et al. 2010. The size of the spleen by magnetic resonance imaging in patients with cystic fibrosis; with and without diabetes--a novel observational study. QJM: An International Journal of Medicine 103(4), pp. 237-242. (10.1093/qjmed/hcp193)

2009

• Wong, F. S., Siew, L. K., Scott, G., Thomas, I. J., Chapman, S., Viret, C. and Wen, L. 2009. Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes. Diabetes 58(5), pp. 1156-1164. (10.2337/db08-0800)
• Wong, F. S. and Wen, L. 2009. Innate immunity and autoimmune disease [Editorial]. Current Molecular Medicine 9(1), pp. 1-3. (10.2174/156652409787314462)
• Ferreira, C., Singh, Y., Furmanski, A. L., Wong, F. S., Garden, O. A. and Dyson, J. 2009. Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America 106(20), pp. 8320-8325. (10.1073/pnas.0808493106)
• Xiao, X. et al. 2009. Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. Journal of Autoimmunity 32(2), pp. 85-93. (10.1016/j.jaut.2008.12.003)
• Thrower, S. L. et al. 2009. Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study. Clinical and Experimental Immunology 155(2), pp. 156-165. (10.1111/j.1365-2249.2008.03814.x)
• Hu, C., Wong, F. S. and Wen, L. 2009. Translational Mini-Review Series on B Cell-Directed Therapies: B cell-directed therapy for autoimmune diseases. Clinical and Experimental Immunology 157(2), pp. 181-190. (10.1111/j.1365-2249.2009.03977.x)
• Xiao, X. et al. 2009. Inflammatory regulation by TLR3 in acute hepatitis. The Journal of Immunology 183(6), pp. 3712-3719. (10.4049/jimmunol.0901221)

2008

• Hu, C., Deng, S., Wong, F. S. and Wen, L. 2008. Anti-CD20 treatment prolongs syngeneic Islet graft survival and delays the onset of recurrent autoimmune diabetes. Annals of the New York Academy of Sciences 1150(1), pp. 217-219. (10.1196/annals.1447.032)
• Wong, F. S. and Wen, L. 2008. IFN-α can both protect against and promote the development of Type 1 diabetes. Annals of the New York Academy of Sciences 1150(1), pp. 187-189. (10.1196/annals.1447.031)
• Wong, F. S., Hu, C., Zhang, L., Du, W., Alexopoulou, L., Flavell, R. A. and Wen, L. 2008. The role of toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice. Annals of the New York Academy of Sciences 1150(1), pp. 146-148. (10.1196/annals.1447.039)
• Wong, F. S. and Wen, L. 2008. Toll-like receptors and diabetes. Annals of the New York Academy of Sciences 1150(1), pp. 123-132. (10.1196/annals.1447.063)
• Scott, G. S. et al. 2008. Developing a novel model system to target insulin-reactive CD8 T cells. Annals of the New York Academy of Sciences 1150(1), pp. 54-58. (10.1196/annals.1447.040)
• Wong, F. S. and Dayan, C. M. 2008. Regulatory T cells in autoimmune endocrine diseases. Trends in Endocrinology & Metabolism 19(8), pp. 292-299. (10.1016/j.tem.2008.07.007)
• Wong, F. S., Siew, L. and Wen, L. 2008. CD8+ T-cells and their interaction with other cells in damage to islet β-cells. Biochemical Society Transactions 36(3), pp. 316-320. (10.1042/BST0360316)
• Rutter, G. and Wong, F. S. 2008. The pancreatic β-cell: birth, life and death. Biochemical Society Transactions 36(3), pp. 267-271. (10.1042/BST0360267)
• Riboulet-Chavey, A., Diraison, F., Siew, L. K., Wong, F. S. and Rutter, G. A. 2008. Inhibition of AMP-activated protein kinase protects pancreatic β-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity. Diabetes 57(2), pp. 415-423. (10.2337/db07-0993)
• Brodie, G. M., Wallberg, M., Santamaria, P., Wong, F. S. and Green, E. A. 2008. B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes. Diabetes 57(4), pp. 909-917. (10.2337/db07-1256)
• Petrich de Marquesini, L. G., Moustakas, A. K., Thomas, I. J., Wen, L., Papadopoulos, G. K. and Wong, F. S. 2008. Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands. European Journal of Immunology 38(1), pp. 240-249. (10.1002/eji.200737762)
• Baker, C., Petrich de Marquesini, L. G., Bishop, A. J., Hedges, A. J., Dayan, C. M. and Wong, F. S. 2008. Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery. Journal of Clinical Immunology 28(4), pp. 350-360. (10.1007/s10875-008-9177-4)
• Wong, F. S. and Dayan, C. M. 2008. Regulatory T cells in autoimmune endocrine diseases. Trends in Endocrinology & Metabolism 19(8), pp. 292-299. (10.1016/j.tem.2008.07.007)
• Wen, L. et al. 2008. Innate immunity and intestinal microbiota in the development of Type 1 diabetes [Letter]. Nature 455(7216), pp. 1109-1113. (10.1038/nature07336)