Ewch i’r prif gynnwys
Wioleta Zelek

Dr Wioleta Zelek

(hi/ei)

Cymrawd RAD/ARUK ac Arweinydd sy'n Dod i'r Amlwg yn UK-DRI

Yr Ysgol Meddygaeth

Email
ZelekW@caerdydd.ac.uk
Telephone
+44 29206 87860
Campuses
Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Llawr 4ydd Llawr, Ystafell 4F10, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Users
Ar gael fel goruchwyliwr ôl-raddedig

Trosolwyg

Mae gen i ffocws ymchwil cryf ar y system ategu, ei bioleg, rolau mewn clefydau ac wrth drin y system ar gyfer therapi. Fy niddordeb penodol yw llwybr terfynell y system ategu sy'n cynhyrchu'r moleciwlau llidiol iawn C5a a'r cymhleth ymosod bilen (MAC). Fy ffocws presennol yw datblygu asiantau gwrth-MAC sy'n gallu atal llid, ac ymchwilio i fioleg sylfaenol strwythur a swyddogaeth MAC i nodi targedau y gellir eu cyffur.

Tîm Ymchwil

Dr Robert Byrne (Cydymaith Ymchwil)

Dr Lewis Watkins (Cydymaith Ymchwil)

Miss Ashmee Almeida (Rheolwr Labordy)

Mr Van Dien Nguyen Nguyen (Cynorthwy-ydd Ymchwil)

Miss Rebekah Cooke (Myfyriwr PhD)

Miss Kirsten Baillie (Myfyriwr PhD)

Miss Laura Nicholls (Myfyriwr PhD)

Mr Matt Bright (Myfyriwr PhD)

Mr Zhizhong Yang (Myfyriwr PhD)

Mr Taine Baggott (Myfyriwr PTY)

Miss Suzy Park (Myfyrwraig MedPharm)

 

https://www.raceagainstdementia.com/rad-fellows/dr-wioleta-zelek/

https://ukdri.ac.uk/team/wioleta-zelek

 

 

Cyhoeddiad

2023

2022

2021

2020

2019

2018

Erthyglau

Gosodiad

Ymchwil

My current focus is on generating anti-complement drugs for treatment of common inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, kidneys disorders and dementia. During the pandemic I have re-focussed my work to address relevant issues; I supported a compassionate use study of anti-complement therapy in severe Covid-19, and developed assays for measurement of antibodies against the RBD domain of the SARS-Cov2 virus.

Grants and awards:

Jan 2022 – present: RAD/ARUK Fellow & UK-DRI Emerging Leader.

"Targeting novel anti-complement drugs to the brain for therapy of dementia.” 

https://ukdri.ac.uk/team/wioleta-zelek

https://www.raceagainstdementia.com/about-us/our-research/our-fellows/dr-wioleta-zelek-race-against-dementia-fellow-and-ukdri-emerging-leader-cardiff-university/

Oct 2020 - Dec 2021: HCRW Fellow.

“Drug design for specific inhibition of the Membrane Attack Complex (MAC) in common inflammatory diseases."

Oct 2019 - Sep 2020: ISSF Fellow.

“Structure-function guided drug design for specific inhibition of the Membrane Attack Complex (MAC) in complement driven diseases.”

Oct 2016 - Sep 2019: PhD Student.

"Targeting the terminal pathway in complement – driven disease."

Bywgraffiad

Jan 2022 – present: Cardiff University, School of Medicine, Dementia Research Institute, Research Fellow. Race Against Dementia / Alzheimer's Research UK Fellowship Award & UK-DRI Emerging Leader status. "Targeting novel anti-complement drugs to the brain for therapy of dementia.” 

Oct 2020 – Dec 2021: Cardiff University, School of Medicine, Research Associate. Health and Care Research Fellowship Award.  “Drug design for specific inhibition of the Membrane Attack Complex (MAC) in common inflammatory diseases.”

Oct 2019 – Sep 2020: Cardiff University, School of Medicine, Research Associate. Institutional Strategic Support Fund via Wellcome Trust Consolidator Award.  “Structure-function guided drug design for specific inhibition of the Membrane Attack Complex (MAC) in complement driven diseases.”

 Oct 2016 – Sep 2019: Cardiff University, School of Medicine, PhD Student.  “Targeting the terminal pathway in complement -  driven disease”.

 Jan 2015 – Sep 2016: Cardiff University, School of Medicine, Research Technician in Prof. B. Paul Morgan Group.  “Complement biomarkers in autoimmune diseases.”

Industry:

Jan 2013 – Dec 2014: RSR Limited, Cardiff. Scientist.

Jan 2007 – Dec 2013: BBI Group, Cardiff, Senior Scientist.

Dec 2006 – Dec 2007: Cardiff and Vale NHS Trust, Cardiff, Medical Laboratory Assistant.

Development of new products: ELISAs and LFAs; improvement of immunoassays performance and manufacturing processes, troubleshooting on products stability and sensitivity issues; data analysis of results obtained and generation of customer reports. Training and supervision of staff. Generation and approval of laboratory protocols; SOP’s, EP’s, QCP’s, PP’s. Accustomed to ISO 9001:2008, ISO13485:2003, FDA, GLP, GMP, PPE, SEQOHS, COSHH, H&S, GCP.

 

Meysydd goruchwyliaeth

Goruchwyliaeth gyfredol

Rebekah Cooke

Rebekah Cooke

Myfyriwr ymchwil

Aurora Veteleanu

Aurora Veteleanu

Myfyriwr ymchwil