![Anthony Campbell](https://profiles-cardiff.imgix.net/attachments/2899?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Publication
2017
- Campbell, A. 2017. Fundamentals of Intracellular Calcium. Wiley-Blackwell.
2015
- Campbell, A. and Matthews, S. B. 2015. Darwin diagnosed. Biological Journal of the Linnean Society 116(4), pp. 964-984. (10.1111/bij.12632)
2014
- Campbell, A. K. 2014. Intracellular calcium. Wiley.
- Campbell, A. K. and Matthews, S. B. 2014. Lactose intolerance. In: Lammert, E. and Zeeb, M. eds. Metabolism of Human Diseases: Organ Physiology and Pathophysiology. Springer, pp. 143-148., (10.1007/978-3-7091-0715-7)
2013
- Berrill, J. W., Gallacher, J. E., Hood, K., Green, J., Matthews, S., Campbell, A. K. and Smith, A. P. 2013. An observational study of cognitive function in patients with irritable bowel syndrome and inflammatory bowel disease. Neurogastroenterology and Motility 25(11), pp. 918-e704. (10.1111/nmo.12219)
- Berrill, J. W., Green, J., Hood, K. and Campbell, A. K. 2013. Symptoms of irritable bowel syndrome in patients with inflammatory bowel disease: examining the role of sub-clinical inflammation and the impact on clinical assessment of disease activity. Alimentary Pharmacology and Therapeutics 38(1), pp. 44-51. (10.1111/apt.12335)
- Cox, C. D., Nomura, T., Ziegler, C. S., Campbell, A. K., Wann, K. T. and Martinac, B. 2013. Selectivity mechanism of the mechanosensitive channel MscS revealed by probing channel subconducting states. Nature Communications 4(7), article number: 2137. (10.1038/ncomms3137)
2012
- Vassel, N. et al. 2012. Enzymatic activity of albumin shown by coelenterazine chemiluminescence. Luminescence 27(3), pp. 234-241. (10.1002/bio.2357)
- Campbell, A. K. 2012. Darwin shines light on the evolution of bioluminescence. Luminescence 27(6), pp. 447-449. (10.1002/bio.2429)
2011
- Eadala, P., Matthews, S. B., Waud, J. P., Green, J. T. and Campbell, A. K. 2011. Association of lactose sensitivity with inflammatory bowel disease - demonstrated by analysis of genetic polymorphism, breath gases and symptoms. Alimentary Pharmacology & Therapeutics 34(7), pp. 735-746. (10.1111/j.1365-2036.2011.04799.x)
2010
- Campbell, A. K. et al. 2010. Bacterial metabolic 'toxins': A new mechanism for lactose and food intolerance, and irritable bowel syndrome. Toxicology 278(3), pp. 268-276. (10.1016/j.tox.2010.09.001)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2010. Lactose in drugs: avoided or allowed to lactose maldigesters? Authors' reply. Alimentary Pharmacology & Therapeutics 31(8), pp. 925-926. (10.1111/j.1365-2036.2010.04253.x)
2009
- Henney, N. C., Li, B., Elford, C., Reviriego, P., Campbell, A. K., Wann, K. T. and Evans, B. A. J. 2009. A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts. American Journal of Physiology - Cell Physiology 297(6), pp. C1397-C1408. (10.1152/ajpcell.00311.2009)
- Campbell, A. K., Waud, J. and Matthews, S. B. 2009. The molecular basis of lactose intolerance. Science Progress 92(3-4), pp. 241-287. (10.3184/003685009X12547510332240)
- Naseem, R., Wann, K. T., Holland, I. B. and Campbell, A. K. 2009. ATP regulates calcium efflux and growth in E. coli. Journal of Molecular Biology 391(1), pp. 42-56. (10.1016/j.jmb.2009.05.064)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2009. Lactose content of gastrointestinal drugs; does it matter? authors' reply. Alimentary Pharmacology & Therapeutics 29(11), pp. 1213. (10.1111/j.1365-2036.2009.04006.x)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2009. Quantifying the 'hidden' lactose in drugs used for the treatment of gastrointestinal conditions. Alimentary Pharmacology & Therapeutics 29(6), pp. 677-687. (10.1111/j.1365-2036.2008.03889.x)
2008
- Naseem, R., Holland, I. B., Jacq, A., Wann, K. T. and Campbell, A. K. 2008. pH and monovalent cations regulate cytosolic free Ca2+ in E. coli. BBA - Biochimica et Biophysica Acta 1778(6), pp. 1415-1422. (10.1016/j.bbamem.2008.02.006)
- Waud, J. P., Matthews, S. B. and Campbell, A. K. 2008. Measurement of breath hydrogen and methane, together with lactase genotype, defines the current best practice for investigation of lactose sensitivity. Annals of Clinical Biochemistry 45(1), pp. 50-58. (10.1258/acb.2007.007147)
- Matthews, S. B., Rowlands, W. P., Chang, D. and Campbell, A. K. 2008. Development of educational material for families with FH [Abstract]. Atherosclerosis 199(1), pp. 234. (10.1016/j.atherosclerosis.2008.04.033)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2008. Lactose intolerance and inflammatory bowel disease [Abstract]. Gut 57(S1), pp. A115-A115.
2007
- Li, B., Henney, N. C., Evans, B. A. J., Reviriego, P., Campbell, A. K. and Wann, K. T. 2007. BK channels in human osteoblast-like cells - Properties and function [Abstract]. Journal of Bone and Mineral Research (JBMR) 22(S1), pp. S161., article number: M144. (10.1002/jbmr.5650221405)
- Naseem, R., Rosser-Davies, S. J., Jones, H., Wann, K. T., Holland, B. and Campbell, A. K. 2007. Cytosolic Ca2+ regulates protein expression in E. coli through release from inclusion bodies. Biochemical and Biophysical Research Communications 360(1), pp. 33-39. (10.1016/j.bbrc.2007.05.223)
- Campbell, A. K., Naseem, R., Wann, K. T., Holland, I. B. and Matthews, S. B. 2007. Fermentation product butane 2,3 diol induces Ca2+ transients in E. coli through activation of lanthanum-sensitive Ca2+ channels. Cell Calcium 41(2), pp. 97-106. (10.1016/j.ceca.2006.05.007)
- Naseem, R., Davies, S. R., Jones, H., Wann, K. T., Holland, I. B. and Campbell, A. K. 2007. Cytosolic Ca2+ regulates protein expression in E-coli through release from inclusion bodies. Biochemical and Biophysical Research Communications 360(1), pp. 33-39. (10.1016/j.bbrc.2007.05.223)
- Henney, N. C., Evans, B. A. J., Campbell, A. K. and Wann, K. T. 2007. TRP channels are both present and functional in human osteoblast-like cells [Abstract]. Journal of Bone and Mineral Research (JBMR) 22(S1), pp. S237. (10.1002/jbmr.5650221406)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2007. "Hidden" lactose in drugs may contribute to symptoms in patients with gastrointestinal conditions and coexisting lactose sensitivity [Abstract]. Gut 56(S2), pp. A142.
- Campbell, A. K., Naseem, R., Wann, K. T., Holland, I. B. and Matthews, S. B. 2007. Fermentation product butane 2,3-diol induces Ca2+ transients in E. coli through activation of lanthanum-sensitive Ca2+ channels. Cell Calcium 41(2), pp. 97-106.
- Campbell, A. K., Naseem, R., Holland, I. B., Matthews, S. B. and Wann, K. T. 2007. Methylglyoxal and other carbohydrate metabolites induce lanthanum-sensitive Ca2+ transients and inhibit growth in E-coli. Archives of Biochemistry and Biophysics 468(1), pp. 107-113. (10.1016/j.abb.2007.09.006)
2006
- Whitaker, S., Herring, P. J., Campbell, A. K., Hill, P. J. and Rees, C. E. D. 2006. Characterization of a fish symbiont of photobacterium phosphoreum with altered spectral properties. In: Szalay, A. A. et al. eds. Bioluminescence and Chemiluminescence: Chemistry, Biology and Applications. San Diego, California: World Scientific Publications, pp. 35-38.
2005
- Campbell, A. K. and Matthews, S. B. 2005. Darwin's illness revealed. Postgraduate Medical Journal 81(954), pp. 248-251. (10.1136/pgmj.2004.025569)
- Matthews, S. B., Waud, J. P., Roberts, A. G. and Campbell, A. K. 2005. Systemic lactose intolerance: a new perspective on an old problem. Postgraduate Medical Journal 81(953), pp. 167-173. (10.1136/pgmj.2004.025551)
2004
- Campbell, A. K., Wann, K. T. and Matthews, S. B. 2004. Lactose causes heart arrhythmia in the water flea Daphnia pulex. Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology 139(2), pp. 225-234. (10.1016/j.cbpc.2004.07.004)
2002
- Campbell, A. K., Holland, I. and Jones, H. 2002. Direct measurement of free Ca(2+) shows different regulation of Ca(2+) between the periplasm and the cytosol of Escherichia coli. Cell Calcium 32(4), pp. 183-192. (10.1016/S0143416002001537)
- Baker, H. L., Errington, R. J., Davies, S. C. and Campbell, A. K. 2002. A mathematical model predicts that calreticulin interacts with the endoplasmic reticulum Ca2+-ATPase. Biophysical journal 82, pp. 582-590.
2001
- Campbell, A. K., Bermudez-Fajardo, A., Sudadhaharan, T. and Waud, J. 2001. Measurement of proteases using chemiluminescence-resonance-energy-transfer chimaeras between green fluorescent protein and aequorin. Biochemical Journal 357(3), pp. 687-697. (10.1042/0264-6021:3570687)
2000
- Baubet, V., Le Mouellic, H., Campbell, A. K., Lucas-Meunier, E., Fossier, P. and Brulet, P. 2000. Chimeric green fluorescent protein-aequorin as bioluminescent Ca2+ reporters at the single-cell level. Proceedings of the National Academy of Sciences of the United States of America 97(13), pp. 7260-7265. (10.1073/pnas.97.13.7260)
- Matthews, S. B. and Campbell, A. K. 2000. When sugar is not so sweet. The Lancet 355(9212), pp. 1330-1330. (10.1016/S0140-6736(00)02116-4)
- Dunstan, S. L., Sala-Newby, G. B., Fajardo, A. B., Taylor, K. M. and Campbell, A. K. 2000. Cloning and expression of the bioluminescent photoprotein pholasin from the bivalve mollusc Pholas dactylus. Journal of Biological Chemistry 275(13), pp. 9403-9409. (10.1074/jbc.275.13.9403)
- Jeffery, J., Kendall, J. M. and Campbell, A. K. 2000. Apoaequorin monitors degradation of endoplasmic reticulum (ER) proteins initiated by loss of ER Ca2+. Biochemical and Biophysical Research Communications 268(3), pp. 711-715. (10.1006/bbrc.2000.2194)
- Sala-Newby, G. B. et al. 2000. Targeted bioluminescent indicators in living cells. In: Ziegler, M. et al. eds. Bioluminescence and Chemiluminescence Part C., Vol. 305. Methods in Enzymology Vol. 305. San Diego, CA: Academic Press, pp. 479-498.
1999
- Holland, I. B., Jones, H. E., Campbell, A. K. and Jacq, A. 1999. An assessment of the role of intracellular free Ca2+ in E-coli. Biochimie 81(8-9), pp. 901-907. (10.1016/S0300-9084(99)00205-9)
- Jones, H. E., Holland, I. B., Baker, H. L. and Campbell, A. K. 1999. Slow changes in cytosolic free Ca2+ in Escherichia coli highlight two putative influx mechanisms in response to changes in extracellular calcium. Cell Calcium 25(3), pp. 265-274. (10.1054/ceca.1999.0028)
1998
- George, C. H., Kendall, J. M., Campbell, A. K. and Evans, W. H. 1998. Connexin-aequorin chimerae report cytoplasmic calcium environments along trafficking pathways leading to gap junction biogenesis in living COS-7 cells. Journal of Biological Chemistry 273(45), pp. 29822-29829. (10.1074/jbc.273.45.29822)
- Roderick, H. L., Llewellyn, D. H., Campbell, A. K. and Kendall, J. M. 1998. Role of calreticulin in regulating intracellular Ca2+ storage and capacitative Ca2+ entry in HeLa cells. Cell Calcium 24(4), pp. 253-262. (10.1016/S0143-4160(98)90049-5)
- Pazzagli, M., Bronstein, I., Campbell, A. K., Pinzani, P., Roda, A. and Wood, K. V. 1998. 2nd meeting of the Italian section of the International Society of Bioluminescence and Chemiluminescence [Preface]. Journal of Bioluminescence and Chemiluminescence 13(5), pp. 285. (10.1002/(SICI)1099-1271(1998090)13:5<285::AID-BIO488>3.0.CO;2-J)
- Sala-Newby, G. B., Taylor, K. M., Badminton, M. N., Rembold, C. M. and Campbell, A. K. 1998. Imaging bioluminescent indicators shows Ca2+ and ATP permeability thresholds in live cells attacked by complement. Immunology 93(4), pp. 601-609. (10.1046/j.1365-2567.1998.00004.x)
- Badminton, M. N., Kendall, J. M., Rembold, C. M. and Campbell, A. K. 1998. Current evidence suggests independent regulation of nuclear calcium. Cell Calcium 23(2-3), pp. 79-86. (10.1016/S0143-4160(98)90105-1)
- Martin, P. E. M. et al. 1998. Assembly of chimeric connexin-aequorin proteins into functional gap junction channels - Reporting intracellular and plasma membrane calcium environments. Journal of Biological Chemistry 273(3), pp. 1719-1726. (10.1074/jbc.273.3.1719)
- George, C. H., Kendall, J. M., Campbell, A. K., Martin, P. E. M. and Evans, W. H. 1998. Reporting the calcium environment in trafficking pathways leading to gap junction biogenesis using connexin-aequorin chimerae. Presented at: 8th International Gap Junction Conference, Key Largo, FL, USA, 12- 17 July 1997 Presented at Werner, R. ed.Gap Junctions: Proceedings of the 8th International Gap Junction Conference, Key Largo, Florida. Amsterdam: IOS Press pp. 140-144.
- Martin, P. E. M. et al. 1998. Targeting connexin-aequorin chimerae to the gap junction. Presented at: 8th International Gap Junction Conference, Key Largo, FL, USA, 12- 17 July 1997 Presented at Werner, R. ed.Gap Junctions: Proceedings of the 8th International Gap Junction Conference, Key Largo, Florida. Amsterdam: IOS Press pp. 107-111.
1997
- Taylor, K. M., Trimby, A. R. and Campbell, A. K. 1997. Mutation of recombinant complement component C9 reveals the significance of the N-terminal region for polymerization. Immunology 91(1), pp. 20-27. (10.1046/j.1365-2567.1997.00225.x)
- Thomson, C. M., Herring, P. J. and Campbell, A. K. 1997. The widespread occurrence and tissue distribution of the imidazolopyrazine luciferins. Journal of Bioluminescence and Chemiluminescence 12(2), pp. 87-91. (10.1002/(SICI)1099-1271(199703/04)12:2<87::AID-BIO438>3.0.CO;2-8)
- Roderick, H. L., Campbell, A. K. and Llewellyn, D. H. 1997. Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors. FEBS Letters 405(2), pp. 181-185. (10.1016/S0014-5793(97)00183-X)
- Rembold, C. M., Kendall, J. M. and Campbell, A. K. 1997. Measurement of changes in sarcoplasmic reticulum [Ca2+] in rat tail artery with targeted apoaequorin delivered by an adenoviral vector. Cell Calcium 21(1), pp. 69-79. (10.1016/S0143-4160(97)90098-1)
1996
- Badminton, M. N., Campbell, A. K. and Rembold, C. M. 1996. Differential regulation of nuclear and cytosolic Ca2+ in HeLa cells. Journal of Biological Chemistry 271(49), pp. 31210-31214. (10.1074/jbc.271.49.31210)
- Trewavas, A., Read, N., Campbell, A. K. and Knight, M. 1996. Transduction of Ca2+ signals in plant cells and compartmentalization of the Ca2+ signal. Biochemical Society Transactions 24(4), pp. 971-974. (10.1042/bst0240971)
- Kendall, J. M., Badminton, M. N., Sala-Newby, G. B., Campbell, A. K. and Rembold, C. M. 1996. Recombinant apoaequorin acting as a pseudo-luciferase reports micromolar changes in the endoplasmic reticulum free Ca2+ of intact cells. Biochemical Journal 318, pp. 383-387.
- Llewellyn, D. H., Kendall, J. M., Sheikh, F. N. and Campbell, A. K. 1996. Induction of calreticulin expression in HeLa cells by depletion of the endoplasmic reticulum Ca2+ store and inhibition of N-linked glycosylation. Biochemical Journal 318, pp. 555-560.
- Campbell, A. K., Trewavas, A. J. and Knight, M. R. 1996. Calcium imaging shows differential sensitivity to cooling and communication in luminous transgenic plants. Cell Calcium 19(3), pp. 211-218. (10.1016/S0143-4160(96)90022-6)
- Sala-Newby, G. B., Thomson, C. M. and Campbell, A. K. 1996. Sequence and biochemical similarities between the luciferases of the glowworm Lampyris noctiluca and the firefly Photinus pyralis. Biochemical Journal 313, pp. 761-767.
- Kendall, J. M., Badminton, M. N., Sala-Newby, G. B., Wilkinson, G. W. G. and Campbell, A. K. 1996. Agonist-stimulated free calcium in subcellular compartments - Delivery of recombinant aequorin to organelles using a replication deficient adenovirus vector. Cell Calcium 19(2), pp. 133-142. (10.1016/S0143-4160(96)90082-2)
- Waud, J. P., Sala-Newby, G. B., Matthews, S. and Campbell, A. K. 1996. Engineering the C-terminus of firefly luciferase as an indicator of covalent modification of proteins. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1292(1), pp. 89-98. (10.1016/0167-4838(95)00199-9)
1995
- Badminton, M. N., Sala-Newby, G. B., Kendall, J. M. and Campbell, A. K. 1995. Differences in stability of recombinant apoaequorin within subcellular compartments. Biochemical and Biophysical Research Communications 217(3), pp. 950-957. (10.1006/bbrc.1995.2862)
- Thomson, C. M., Herring, P. J. and Campbell, A. K. 1995. Coelenterazine distribution and luciferase characteristics in oceanic decapod crustaceans. Marine Biology 124(2), pp. 197-207. (10.1007/BF00347123)
- Campbell, A. K., Badminton, M. N., Kendall, J. M., Sala-Newby, G. B. and Wilkinson, G. W. G. 1995. Free Ca2+ in cellular compartments studied using targeted aequorin [Abstract]. Journal of Physiology 487(P), pp. 7S.
- Kendall, J. M., Badminton, M. N., Sala-Newby, G. B., Wilkinson, G. W. G., Dormer, R. L. and Campbell, A. K. 1995. Changes in free Ca2+ in organelles monitored by targeted recombinant aequorin; use of replication-deficient adenovirus vectors [Communication]. Journal of Physiology 487, pp. 19P.
- Llewellyn, D. H., Sheikh, F. N., Kendall, J. M. and Campbell, A. K. 1995. Upregulation of calreticulin expression in HeLa cells by calcium-stress [Communication]. Biochemical Society Transactions 23(2), pp. S330., article number: 23. (10.1042/bst023330s)
- Haley, A., Russell, A. J., Wood, N., Allan, A. C., Knight, M., Campbell, A. K. and Trewavas, A. J. 1995. Effects of mechanical signaling on plant cell cytosolic calcium. Proceedings of the National Academy of Sciences of the United States of America 92(10), pp. 4124-4128.
- Laffafian, I., Davies, E. V., Campbell, A. K. and Hallett, M. B. 1995. Complement component C9-dependent cytosolic free Ca2+ rise and recovery in neutrophils. Cell Calcium 17(4), pp. 279-286. (10.1016/0143-4160(95)90074-8)
- Watkins, N. J., Knight, M. R., Trewavas, A. J. and Campbell, A. K. 1995. Free calcium transients in chemotactic and non-chemotactic strains of Escherichia coli determined by using recombinant aequorin. Biochemical Journal 306, pp. 865-869.
- Thomson, C. M., Herring, P. J. and Campbell, A. K. 1995. Evidence For De Novo Biosynthesis of Coelenterazine in the Bioluminescent Midwater Shrimp, Systellaspis Debilis C. Journal of the Marine Biological Association of the United Kingdom 75(1), pp. 165-171. (10.1017/S0025315400015277)
- Badminton, M. N., Kendall, J. M., Sala-Newby, G. B. and Campbell, A. K. 1995. Nucleoplasmin-targeted aequorin provides evidence for a nuclear calcium barrier. Experimental Cell Research 216(1), pp. 236-243. (10.1006/excr.1995.1030)
1994
- Taylor, K. M., Morgan, B. P. and Campbell, A. K. 1994. Altered glycosylation and selected mutation in recombinant human complement component C9: effects on haemolytic activity. Immunology 83(3), pp. 501-506.
- Kendall, J. M., Badminton, M. N., Dormer, R. L. and Campbell, A. K. 1994. Changes in free calcium in the endoplasmic reticulum of living cells detected using targeted aequorin. Analytical Biochemistry 221(1), pp. 173-181. (10.1006/abio.1994.1394)
- Davies, E. V., Williams, B. D., Whiston, R. J., Cooper, A. M., Campbell, A. K. and Hallett, M. B. 1994. Altered Ca2+ signalling in human neutrophils from inflammatory sites. Annals of the Rheumatic Diseases 53(7), pp. 446-449. (10.1136/ard.53.7.446)
- Sala-Newby, G. B. and Campbell, A. K. 1994. Stepwise removal of the C-terminal 12 amino acids of firefly luciferase results in graded loss of activity. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1206(1), pp. 155-160. (10.1016/0167-4838(94)90084-1)
- Davies, E. V., Campbell, A. K. and Hallett, M. B. 1994. Ca2+ oscillations in neutrophils triggered by immune complexes result from Ca2+ influx. Immunology 82(1), pp. 57-62.
- Taylor, K. M., Luzio, J. P. and Campbell, A. K. 1994. A method for in vitro synthesis of unglycosylated recombinant complement component C9. Journal of Immunological Methods 167(1-2), pp. 129-137. (10.1016/0022-1759(94)90082-5)
1993
- Watkins, N. J. and Campbell, A. K. 1993. Requirement of the C-terminal proline residue for stability of the Ca(2+)-activated photoprotein aequorin. Biochemical Journal 293(1), pp. 181-185.
- Knight, M. R., Read, N. D., Campbell, A. K. and Trewavas, A. J. 1993. Imaging calcium dynamics in living plants using semi-synthetic recombinant aequorins. Journal of Cell Biology 121(1), pp. 83-90. (10.1083/jcb.121.1.83)
1990
- Hallett, M. B., Dormer, R. L. and Campbell, A. K. 1990. Cytoplasmic free calcium: measurement and manipulation in living cells. In: Siddle, K. and Hutton, J. C. eds. Peptide hormones: a practical approach. Practical Approach Series Vol. 71. Oxford: IRL Press, pp. 115-150.
1983
- Hallett, M. B. and Campbell, A. K. 1983. Direct measurement of intracellular free Ca2+ in rat peritoneal macrophages: correlation with oxygen-radical production. Immunology 50(3), pp. 487-495.
- Hallett, M. B. and Campbell, A. K. 1983. Two distinct mechanisms for stimulation of oxygen-radical production by polymorphonuclear leucocytes. Biochemical Journal 216(2), pp. 459-465.
- Campbell, A. K. and Hallett, M. B. 1983. Measurement of intracellular calcium ions and oxygen radicals in polymorphonuclear leucocyte-erythrocyte ‘ghost’ hybrids. The Journal of Physiology 338(1), pp. 537-550. (10.1113/jphysiol.1983.sp014688)
1979
- Campbell, A. K. and Hallett, M. B. 1979. Luminescence in cells and vesicles isolated from the hydroid Obelia geniculata [proceedings]. The Journal of Physiology 287, pp. 4P-5P.
1978
- Dormer, R. L., Hallett, M. B. and Campbell, A. K. 1978. The incorporation of the calcium-activated photoprotein into isolated rat fat-cells by liposome-cell fusion [proceedings]. Biochemical Society Transactions 6(3), pp. 570-572.
Articles
- Campbell, A. and Matthews, S. B. 2015. Darwin diagnosed. Biological Journal of the Linnean Society 116(4), pp. 964-984. (10.1111/bij.12632)
- Berrill, J. W., Gallacher, J. E., Hood, K., Green, J., Matthews, S., Campbell, A. K. and Smith, A. P. 2013. An observational study of cognitive function in patients with irritable bowel syndrome and inflammatory bowel disease. Neurogastroenterology and Motility 25(11), pp. 918-e704. (10.1111/nmo.12219)
- Berrill, J. W., Green, J., Hood, K. and Campbell, A. K. 2013. Symptoms of irritable bowel syndrome in patients with inflammatory bowel disease: examining the role of sub-clinical inflammation and the impact on clinical assessment of disease activity. Alimentary Pharmacology and Therapeutics 38(1), pp. 44-51. (10.1111/apt.12335)
- Cox, C. D., Nomura, T., Ziegler, C. S., Campbell, A. K., Wann, K. T. and Martinac, B. 2013. Selectivity mechanism of the mechanosensitive channel MscS revealed by probing channel subconducting states. Nature Communications 4(7), article number: 2137. (10.1038/ncomms3137)
- Vassel, N. et al. 2012. Enzymatic activity of albumin shown by coelenterazine chemiluminescence. Luminescence 27(3), pp. 234-241. (10.1002/bio.2357)
- Campbell, A. K. 2012. Darwin shines light on the evolution of bioluminescence. Luminescence 27(6), pp. 447-449. (10.1002/bio.2429)
- Eadala, P., Matthews, S. B., Waud, J. P., Green, J. T. and Campbell, A. K. 2011. Association of lactose sensitivity with inflammatory bowel disease - demonstrated by analysis of genetic polymorphism, breath gases and symptoms. Alimentary Pharmacology & Therapeutics 34(7), pp. 735-746. (10.1111/j.1365-2036.2011.04799.x)
- Campbell, A. K. et al. 2010. Bacterial metabolic 'toxins': A new mechanism for lactose and food intolerance, and irritable bowel syndrome. Toxicology 278(3), pp. 268-276. (10.1016/j.tox.2010.09.001)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2010. Lactose in drugs: avoided or allowed to lactose maldigesters? Authors' reply. Alimentary Pharmacology & Therapeutics 31(8), pp. 925-926. (10.1111/j.1365-2036.2010.04253.x)
- Henney, N. C., Li, B., Elford, C., Reviriego, P., Campbell, A. K., Wann, K. T. and Evans, B. A. J. 2009. A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts. American Journal of Physiology - Cell Physiology 297(6), pp. C1397-C1408. (10.1152/ajpcell.00311.2009)
- Campbell, A. K., Waud, J. and Matthews, S. B. 2009. The molecular basis of lactose intolerance. Science Progress 92(3-4), pp. 241-287. (10.3184/003685009X12547510332240)
- Naseem, R., Wann, K. T., Holland, I. B. and Campbell, A. K. 2009. ATP regulates calcium efflux and growth in E. coli. Journal of Molecular Biology 391(1), pp. 42-56. (10.1016/j.jmb.2009.05.064)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2009. Lactose content of gastrointestinal drugs; does it matter? authors' reply. Alimentary Pharmacology & Therapeutics 29(11), pp. 1213. (10.1111/j.1365-2036.2009.04006.x)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2009. Quantifying the 'hidden' lactose in drugs used for the treatment of gastrointestinal conditions. Alimentary Pharmacology & Therapeutics 29(6), pp. 677-687. (10.1111/j.1365-2036.2008.03889.x)
- Naseem, R., Holland, I. B., Jacq, A., Wann, K. T. and Campbell, A. K. 2008. pH and monovalent cations regulate cytosolic free Ca2+ in E. coli. BBA - Biochimica et Biophysica Acta 1778(6), pp. 1415-1422. (10.1016/j.bbamem.2008.02.006)
- Waud, J. P., Matthews, S. B. and Campbell, A. K. 2008. Measurement of breath hydrogen and methane, together with lactase genotype, defines the current best practice for investigation of lactose sensitivity. Annals of Clinical Biochemistry 45(1), pp. 50-58. (10.1258/acb.2007.007147)
- Matthews, S. B., Rowlands, W. P., Chang, D. and Campbell, A. K. 2008. Development of educational material for families with FH [Abstract]. Atherosclerosis 199(1), pp. 234. (10.1016/j.atherosclerosis.2008.04.033)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2008. Lactose intolerance and inflammatory bowel disease [Abstract]. Gut 57(S1), pp. A115-A115.
- Li, B., Henney, N. C., Evans, B. A. J., Reviriego, P., Campbell, A. K. and Wann, K. T. 2007. BK channels in human osteoblast-like cells - Properties and function [Abstract]. Journal of Bone and Mineral Research (JBMR) 22(S1), pp. S161., article number: M144. (10.1002/jbmr.5650221405)
- Naseem, R., Rosser-Davies, S. J., Jones, H., Wann, K. T., Holland, B. and Campbell, A. K. 2007. Cytosolic Ca2+ regulates protein expression in E. coli through release from inclusion bodies. Biochemical and Biophysical Research Communications 360(1), pp. 33-39. (10.1016/j.bbrc.2007.05.223)
- Campbell, A. K., Naseem, R., Wann, K. T., Holland, I. B. and Matthews, S. B. 2007. Fermentation product butane 2,3 diol induces Ca2+ transients in E. coli through activation of lanthanum-sensitive Ca2+ channels. Cell Calcium 41(2), pp. 97-106. (10.1016/j.ceca.2006.05.007)
- Naseem, R., Davies, S. R., Jones, H., Wann, K. T., Holland, I. B. and Campbell, A. K. 2007. Cytosolic Ca2+ regulates protein expression in E-coli through release from inclusion bodies. Biochemical and Biophysical Research Communications 360(1), pp. 33-39. (10.1016/j.bbrc.2007.05.223)
- Henney, N. C., Evans, B. A. J., Campbell, A. K. and Wann, K. T. 2007. TRP channels are both present and functional in human osteoblast-like cells [Abstract]. Journal of Bone and Mineral Research (JBMR) 22(S1), pp. S237. (10.1002/jbmr.5650221406)
- Eadala, P., Waud, J. P., Matthews, S. B., Green, J. T. and Campbell, A. K. 2007. "Hidden" lactose in drugs may contribute to symptoms in patients with gastrointestinal conditions and coexisting lactose sensitivity [Abstract]. Gut 56(S2), pp. A142.
- Campbell, A. K., Naseem, R., Wann, K. T., Holland, I. B. and Matthews, S. B. 2007. Fermentation product butane 2,3-diol induces Ca2+ transients in E. coli through activation of lanthanum-sensitive Ca2+ channels. Cell Calcium 41(2), pp. 97-106.
- Campbell, A. K., Naseem, R., Holland, I. B., Matthews, S. B. and Wann, K. T. 2007. Methylglyoxal and other carbohydrate metabolites induce lanthanum-sensitive Ca2+ transients and inhibit growth in E-coli. Archives of Biochemistry and Biophysics 468(1), pp. 107-113. (10.1016/j.abb.2007.09.006)
- Campbell, A. K. and Matthews, S. B. 2005. Darwin's illness revealed. Postgraduate Medical Journal 81(954), pp. 248-251. (10.1136/pgmj.2004.025569)
- Matthews, S. B., Waud, J. P., Roberts, A. G. and Campbell, A. K. 2005. Systemic lactose intolerance: a new perspective on an old problem. Postgraduate Medical Journal 81(953), pp. 167-173. (10.1136/pgmj.2004.025551)
- Campbell, A. K., Wann, K. T. and Matthews, S. B. 2004. Lactose causes heart arrhythmia in the water flea Daphnia pulex. Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology 139(2), pp. 225-234. (10.1016/j.cbpc.2004.07.004)
- Campbell, A. K., Holland, I. and Jones, H. 2002. Direct measurement of free Ca(2+) shows different regulation of Ca(2+) between the periplasm and the cytosol of Escherichia coli. Cell Calcium 32(4), pp. 183-192. (10.1016/S0143416002001537)
- Baker, H. L., Errington, R. J., Davies, S. C. and Campbell, A. K. 2002. A mathematical model predicts that calreticulin interacts with the endoplasmic reticulum Ca2+-ATPase. Biophysical journal 82, pp. 582-590.
- Campbell, A. K., Bermudez-Fajardo, A., Sudadhaharan, T. and Waud, J. 2001. Measurement of proteases using chemiluminescence-resonance-energy-transfer chimaeras between green fluorescent protein and aequorin. Biochemical Journal 357(3), pp. 687-697. (10.1042/0264-6021:3570687)
- Baubet, V., Le Mouellic, H., Campbell, A. K., Lucas-Meunier, E., Fossier, P. and Brulet, P. 2000. Chimeric green fluorescent protein-aequorin as bioluminescent Ca2+ reporters at the single-cell level. Proceedings of the National Academy of Sciences of the United States of America 97(13), pp. 7260-7265. (10.1073/pnas.97.13.7260)
- Matthews, S. B. and Campbell, A. K. 2000. When sugar is not so sweet. The Lancet 355(9212), pp. 1330-1330. (10.1016/S0140-6736(00)02116-4)
- Dunstan, S. L., Sala-Newby, G. B., Fajardo, A. B., Taylor, K. M. and Campbell, A. K. 2000. Cloning and expression of the bioluminescent photoprotein pholasin from the bivalve mollusc Pholas dactylus. Journal of Biological Chemistry 275(13), pp. 9403-9409. (10.1074/jbc.275.13.9403)
- Jeffery, J., Kendall, J. M. and Campbell, A. K. 2000. Apoaequorin monitors degradation of endoplasmic reticulum (ER) proteins initiated by loss of ER Ca2+. Biochemical and Biophysical Research Communications 268(3), pp. 711-715. (10.1006/bbrc.2000.2194)
- Holland, I. B., Jones, H. E., Campbell, A. K. and Jacq, A. 1999. An assessment of the role of intracellular free Ca2+ in E-coli. Biochimie 81(8-9), pp. 901-907. (10.1016/S0300-9084(99)00205-9)
- Jones, H. E., Holland, I. B., Baker, H. L. and Campbell, A. K. 1999. Slow changes in cytosolic free Ca2+ in Escherichia coli highlight two putative influx mechanisms in response to changes in extracellular calcium. Cell Calcium 25(3), pp. 265-274. (10.1054/ceca.1999.0028)
- George, C. H., Kendall, J. M., Campbell, A. K. and Evans, W. H. 1998. Connexin-aequorin chimerae report cytoplasmic calcium environments along trafficking pathways leading to gap junction biogenesis in living COS-7 cells. Journal of Biological Chemistry 273(45), pp. 29822-29829. (10.1074/jbc.273.45.29822)
- Roderick, H. L., Llewellyn, D. H., Campbell, A. K. and Kendall, J. M. 1998. Role of calreticulin in regulating intracellular Ca2+ storage and capacitative Ca2+ entry in HeLa cells. Cell Calcium 24(4), pp. 253-262. (10.1016/S0143-4160(98)90049-5)
- Pazzagli, M., Bronstein, I., Campbell, A. K., Pinzani, P., Roda, A. and Wood, K. V. 1998. 2nd meeting of the Italian section of the International Society of Bioluminescence and Chemiluminescence [Preface]. Journal of Bioluminescence and Chemiluminescence 13(5), pp. 285. (10.1002/(SICI)1099-1271(1998090)13:5<285::AID-BIO488>3.0.CO;2-J)
- Sala-Newby, G. B., Taylor, K. M., Badminton, M. N., Rembold, C. M. and Campbell, A. K. 1998. Imaging bioluminescent indicators shows Ca2+ and ATP permeability thresholds in live cells attacked by complement. Immunology 93(4), pp. 601-609. (10.1046/j.1365-2567.1998.00004.x)
- Badminton, M. N., Kendall, J. M., Rembold, C. M. and Campbell, A. K. 1998. Current evidence suggests independent regulation of nuclear calcium. Cell Calcium 23(2-3), pp. 79-86. (10.1016/S0143-4160(98)90105-1)
- Martin, P. E. M. et al. 1998. Assembly of chimeric connexin-aequorin proteins into functional gap junction channels - Reporting intracellular and plasma membrane calcium environments. Journal of Biological Chemistry 273(3), pp. 1719-1726. (10.1074/jbc.273.3.1719)
- Taylor, K. M., Trimby, A. R. and Campbell, A. K. 1997. Mutation of recombinant complement component C9 reveals the significance of the N-terminal region for polymerization. Immunology 91(1), pp. 20-27. (10.1046/j.1365-2567.1997.00225.x)
- Thomson, C. M., Herring, P. J. and Campbell, A. K. 1997. The widespread occurrence and tissue distribution of the imidazolopyrazine luciferins. Journal of Bioluminescence and Chemiluminescence 12(2), pp. 87-91. (10.1002/(SICI)1099-1271(199703/04)12:2<87::AID-BIO438>3.0.CO;2-8)
- Roderick, H. L., Campbell, A. K. and Llewellyn, D. H. 1997. Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors. FEBS Letters 405(2), pp. 181-185. (10.1016/S0014-5793(97)00183-X)
- Rembold, C. M., Kendall, J. M. and Campbell, A. K. 1997. Measurement of changes in sarcoplasmic reticulum [Ca2+] in rat tail artery with targeted apoaequorin delivered by an adenoviral vector. Cell Calcium 21(1), pp. 69-79. (10.1016/S0143-4160(97)90098-1)
- Badminton, M. N., Campbell, A. K. and Rembold, C. M. 1996. Differential regulation of nuclear and cytosolic Ca2+ in HeLa cells. Journal of Biological Chemistry 271(49), pp. 31210-31214. (10.1074/jbc.271.49.31210)
- Trewavas, A., Read, N., Campbell, A. K. and Knight, M. 1996. Transduction of Ca2+ signals in plant cells and compartmentalization of the Ca2+ signal. Biochemical Society Transactions 24(4), pp. 971-974. (10.1042/bst0240971)
- Kendall, J. M., Badminton, M. N., Sala-Newby, G. B., Campbell, A. K. and Rembold, C. M. 1996. Recombinant apoaequorin acting as a pseudo-luciferase reports micromolar changes in the endoplasmic reticulum free Ca2+ of intact cells. Biochemical Journal 318, pp. 383-387.
- Llewellyn, D. H., Kendall, J. M., Sheikh, F. N. and Campbell, A. K. 1996. Induction of calreticulin expression in HeLa cells by depletion of the endoplasmic reticulum Ca2+ store and inhibition of N-linked glycosylation. Biochemical Journal 318, pp. 555-560.
- Campbell, A. K., Trewavas, A. J. and Knight, M. R. 1996. Calcium imaging shows differential sensitivity to cooling and communication in luminous transgenic plants. Cell Calcium 19(3), pp. 211-218. (10.1016/S0143-4160(96)90022-6)
- Sala-Newby, G. B., Thomson, C. M. and Campbell, A. K. 1996. Sequence and biochemical similarities between the luciferases of the glowworm Lampyris noctiluca and the firefly Photinus pyralis. Biochemical Journal 313, pp. 761-767.
- Kendall, J. M., Badminton, M. N., Sala-Newby, G. B., Wilkinson, G. W. G. and Campbell, A. K. 1996. Agonist-stimulated free calcium in subcellular compartments - Delivery of recombinant aequorin to organelles using a replication deficient adenovirus vector. Cell Calcium 19(2), pp. 133-142. (10.1016/S0143-4160(96)90082-2)
- Waud, J. P., Sala-Newby, G. B., Matthews, S. and Campbell, A. K. 1996. Engineering the C-terminus of firefly luciferase as an indicator of covalent modification of proteins. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1292(1), pp. 89-98. (10.1016/0167-4838(95)00199-9)
- Badminton, M. N., Sala-Newby, G. B., Kendall, J. M. and Campbell, A. K. 1995. Differences in stability of recombinant apoaequorin within subcellular compartments. Biochemical and Biophysical Research Communications 217(3), pp. 950-957. (10.1006/bbrc.1995.2862)
- Thomson, C. M., Herring, P. J. and Campbell, A. K. 1995. Coelenterazine distribution and luciferase characteristics in oceanic decapod crustaceans. Marine Biology 124(2), pp. 197-207. (10.1007/BF00347123)
- Campbell, A. K., Badminton, M. N., Kendall, J. M., Sala-Newby, G. B. and Wilkinson, G. W. G. 1995. Free Ca2+ in cellular compartments studied using targeted aequorin [Abstract]. Journal of Physiology 487(P), pp. 7S.
- Kendall, J. M., Badminton, M. N., Sala-Newby, G. B., Wilkinson, G. W. G., Dormer, R. L. and Campbell, A. K. 1995. Changes in free Ca2+ in organelles monitored by targeted recombinant aequorin; use of replication-deficient adenovirus vectors [Communication]. Journal of Physiology 487, pp. 19P.
- Llewellyn, D. H., Sheikh, F. N., Kendall, J. M. and Campbell, A. K. 1995. Upregulation of calreticulin expression in HeLa cells by calcium-stress [Communication]. Biochemical Society Transactions 23(2), pp. S330., article number: 23. (10.1042/bst023330s)
- Haley, A., Russell, A. J., Wood, N., Allan, A. C., Knight, M., Campbell, A. K. and Trewavas, A. J. 1995. Effects of mechanical signaling on plant cell cytosolic calcium. Proceedings of the National Academy of Sciences of the United States of America 92(10), pp. 4124-4128.
- Laffafian, I., Davies, E. V., Campbell, A. K. and Hallett, M. B. 1995. Complement component C9-dependent cytosolic free Ca2+ rise and recovery in neutrophils. Cell Calcium 17(4), pp. 279-286. (10.1016/0143-4160(95)90074-8)
- Watkins, N. J., Knight, M. R., Trewavas, A. J. and Campbell, A. K. 1995. Free calcium transients in chemotactic and non-chemotactic strains of Escherichia coli determined by using recombinant aequorin. Biochemical Journal 306, pp. 865-869.
- Thomson, C. M., Herring, P. J. and Campbell, A. K. 1995. Evidence For De Novo Biosynthesis of Coelenterazine in the Bioluminescent Midwater Shrimp, Systellaspis Debilis C. Journal of the Marine Biological Association of the United Kingdom 75(1), pp. 165-171. (10.1017/S0025315400015277)
- Badminton, M. N., Kendall, J. M., Sala-Newby, G. B. and Campbell, A. K. 1995. Nucleoplasmin-targeted aequorin provides evidence for a nuclear calcium barrier. Experimental Cell Research 216(1), pp. 236-243. (10.1006/excr.1995.1030)
- Taylor, K. M., Morgan, B. P. and Campbell, A. K. 1994. Altered glycosylation and selected mutation in recombinant human complement component C9: effects on haemolytic activity. Immunology 83(3), pp. 501-506.
- Kendall, J. M., Badminton, M. N., Dormer, R. L. and Campbell, A. K. 1994. Changes in free calcium in the endoplasmic reticulum of living cells detected using targeted aequorin. Analytical Biochemistry 221(1), pp. 173-181. (10.1006/abio.1994.1394)
- Davies, E. V., Williams, B. D., Whiston, R. J., Cooper, A. M., Campbell, A. K. and Hallett, M. B. 1994. Altered Ca2+ signalling in human neutrophils from inflammatory sites. Annals of the Rheumatic Diseases 53(7), pp. 446-449. (10.1136/ard.53.7.446)
- Sala-Newby, G. B. and Campbell, A. K. 1994. Stepwise removal of the C-terminal 12 amino acids of firefly luciferase results in graded loss of activity. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1206(1), pp. 155-160. (10.1016/0167-4838(94)90084-1)
- Davies, E. V., Campbell, A. K. and Hallett, M. B. 1994. Ca2+ oscillations in neutrophils triggered by immune complexes result from Ca2+ influx. Immunology 82(1), pp. 57-62.
- Taylor, K. M., Luzio, J. P. and Campbell, A. K. 1994. A method for in vitro synthesis of unglycosylated recombinant complement component C9. Journal of Immunological Methods 167(1-2), pp. 129-137. (10.1016/0022-1759(94)90082-5)
- Watkins, N. J. and Campbell, A. K. 1993. Requirement of the C-terminal proline residue for stability of the Ca(2+)-activated photoprotein aequorin. Biochemical Journal 293(1), pp. 181-185.
- Knight, M. R., Read, N. D., Campbell, A. K. and Trewavas, A. J. 1993. Imaging calcium dynamics in living plants using semi-synthetic recombinant aequorins. Journal of Cell Biology 121(1), pp. 83-90. (10.1083/jcb.121.1.83)
- Hallett, M. B. and Campbell, A. K. 1983. Direct measurement of intracellular free Ca2+ in rat peritoneal macrophages: correlation with oxygen-radical production. Immunology 50(3), pp. 487-495.
- Hallett, M. B. and Campbell, A. K. 1983. Two distinct mechanisms for stimulation of oxygen-radical production by polymorphonuclear leucocytes. Biochemical Journal 216(2), pp. 459-465.
- Campbell, A. K. and Hallett, M. B. 1983. Measurement of intracellular calcium ions and oxygen radicals in polymorphonuclear leucocyte-erythrocyte ‘ghost’ hybrids. The Journal of Physiology 338(1), pp. 537-550. (10.1113/jphysiol.1983.sp014688)
- Campbell, A. K. and Hallett, M. B. 1979. Luminescence in cells and vesicles isolated from the hydroid Obelia geniculata [proceedings]. The Journal of Physiology 287, pp. 4P-5P.
- Dormer, R. L., Hallett, M. B. and Campbell, A. K. 1978. The incorporation of the calcium-activated photoprotein into isolated rat fat-cells by liposome-cell fusion [proceedings]. Biochemical Society Transactions 6(3), pp. 570-572.
Book sections
- Campbell, A. K. and Matthews, S. B. 2014. Lactose intolerance. In: Lammert, E. and Zeeb, M. eds. Metabolism of Human Diseases: Organ Physiology and Pathophysiology. Springer, pp. 143-148., (10.1007/978-3-7091-0715-7)
- Whitaker, S., Herring, P. J., Campbell, A. K., Hill, P. J. and Rees, C. E. D. 2006. Characterization of a fish symbiont of photobacterium phosphoreum with altered spectral properties. In: Szalay, A. A. et al. eds. Bioluminescence and Chemiluminescence: Chemistry, Biology and Applications. San Diego, California: World Scientific Publications, pp. 35-38.
- Sala-Newby, G. B. et al. 2000. Targeted bioluminescent indicators in living cells. In: Ziegler, M. et al. eds. Bioluminescence and Chemiluminescence Part C., Vol. 305. Methods in Enzymology Vol. 305. San Diego, CA: Academic Press, pp. 479-498.
- Hallett, M. B., Dormer, R. L. and Campbell, A. K. 1990. Cytoplasmic free calcium: measurement and manipulation in living cells. In: Siddle, K. and Hutton, J. C. eds. Peptide hormones: a practical approach. Practical Approach Series Vol. 71. Oxford: IRL Press, pp. 115-150.
Books
- Campbell, A. 2017. Fundamentals of Intracellular Calcium. Wiley-Blackwell.
- Campbell, A. K. 2014. Intracellular calcium. Wiley.
Conferences
- George, C. H., Kendall, J. M., Campbell, A. K., Martin, P. E. M. and Evans, W. H. 1998. Reporting the calcium environment in trafficking pathways leading to gap junction biogenesis using connexin-aequorin chimerae. Presented at: 8th International Gap Junction Conference, Key Largo, FL, USA, 12- 17 July 1997 Presented at Werner, R. ed.Gap Junctions: Proceedings of the 8th International Gap Junction Conference, Key Largo, Florida. Amsterdam: IOS Press pp. 140-144.
- Martin, P. E. M. et al. 1998. Targeting connexin-aequorin chimerae to the gap junction. Presented at: 8th International Gap Junction Conference, Key Largo, FL, USA, 12- 17 July 1997 Presented at Werner, R. ed.Gap Junctions: Proceedings of the 8th International Gap Junction Conference, Key Largo, Florida. Amsterdam: IOS Press pp. 107-111.
Research
My researchers have taken me from the biochemistry of deep-sea bioluminescence to the molecular basis of disease and food intolerance. I am international authority on intracellular signalling, particularly intracellular calcium, and in chemi- and bio-luminescence, discovering the most common bioluminescent chemistry in the sea, and pioneered genetic engineering of bioluminescent proteins to measure chemical events in living cells, including a way to target these to specific sites within the living cells. I have published 8 books, over 200 peer-reviewed papers, and several world-wide patents. I discovered a new mechanism, explaining the symptoms of food intolerance, based on metabolic toxins from gut bacteria, which is important in diabetes and cancer, and has shown this explains the illness that afflicted Charles Darwin for 50 years.
The Public Understanding of Science in Health (PUSH) group that I founded in this University in 1993 involves some 150 staff at all levels across five academic Schools. This group runs events throughout the year, including Science in Health Open Day, regularly now with over 550 students and teachers (voted one of the top 3 events in National Science Week by the British Science Association in 2009), a public lecture programme, the Nuffield and other student research schemes. In 1994, I founded The Darwin Centre for Biology and Medicine (www.darwincentre.com), and founded the Welston Court Science Centre in Pembrokeshire in 1996. This led, to me founding the Pembrokeshire Darwin Science Festival, now in its twelfth year. The Darwin Centre is now a leading focus for outreach and public engagement in Wales, organising over 150 events each year, having received financial support from public and private sources, including the Millennium Festival, COPUS, EU, Dragon LNG, The Waterloo Foundation, and other organisations in Pembrokeshire. Staff at Cardiff University contribute regularly to the Darwin Centre events, which have impact nationally and internationally.
I am also the founder of The Young Darwinian, a journal for school students to publish their projects and experiences - www.theyoungdarwinian.com
Research interests
I am an expertise in chemi- and bio-luminescence, and proposed a revolutionary mechanism: 'The bacterial metabolic toxin hypothesis', which provides a new mechanism to explain some of the most common disorders seen by GPs, including irritable gut syndrome, lactose and food intolerance, diabetes and some cancers.
A member of the School's Pharmacology & Physiology Research Discipline.
Current areas of interest
- Calcium signalling and the measurement of free calcium in live cells, particularly bacteria
- Lactose and food intolerance, with other gut disorders such as irritable bowel syndrome and inflammatory bowel disease
- Bioluminescence and its evolutionary origin
- Charles and Erasmus Darwin
- Public engagement of science
See also:
Biography
I am one of life's genuine enthusiasts. polymath, having extraordinary abilities as an original scientific thinker, inspiring communicator, musician, networker, and cook. As a result of my work on the bioluminescent jelly fish Obelia, I had the idea of replacing radioactivity in immunoassay and DNA technology by a chemical reaction that makes light - chemiluminescence. This invention has now transformed clinical diagnosis, and is a world leading technology, now used in several 100 million clinical tests per year, world-wide. It has brought substantial income into Cardiff University, and Wales, and has received several accolades for this University, including the Queen's Anniversary Prize for Higher Education in 1998. 'It all started with me being curious about how a luminous jelly fish produced its flash'. The technology was selected in 2006 by the Eureka project from Universities UK as one of the 100 most important inventions and discoveries from UK Universities in the last 50 years. In 2010, a report from the Russell group of Universities on the impact of basic research on the economy selected my work on bioluminescence as the only case study from Wales.
I was born in 1945 in Bangor, North Wales, but grew up in London, and educated at The City of London School, obtaining an exhibition, and then a first-class degree and PhD in Natural Sciences at Pembroke College, Cambridge. In 1970, I was appointed Lecturer at the Welsh National School of Medicine, where I worked for 40 years. I am now Professor here.
I am a Fellow of the Linnean Society and have been a member of the Marine Biological Association since 1975, and The Biochemical Society since 1968. I am also a member of The History of Natural History Society, and The British Science Association, and a founder member of the Erasmus Darwin Foundation. In 2000, I was elected a foreign member of the Royal Swedish Academy of Sciences, Uppsala.
In 2020 I published a mystery novel entitled, Mirror Image: What Darwin Missed. The novel is a piece of science communication for lay readers to help explain some of the gaps in the theory of evolution by natural selection, and is set on the beautiful island of Anglesey off the coast of North Wales.
I was honoured to receive a CBE in the 2021 New years honours from Her Majesty the Queen. I was also a cofounder of The young Darwinian. And founded The Darwin Centre in 1994 where it has been a huge success in Pembrokeshire.
Honours and awards
- Inspire Wales Award for Science and Technology (2011)
- Fellow of the Linnean Society
- Fellow of the Learned Society of Wales
