Professor Vic Duance

2021

• Stadnik, P. S. et al. 2021. Regulation of microRNA‐221, ‐222, ‐21 and ‐27 in articular cartilage subjected to abnormal compressive forces. Journal of Physiology 599(1), pp. 143-155., article number: V. (10.1113/JP279810)

2018

• Gilbert, S. J., Bonnet, C. S., Stadnik, P., Duance, V. C., Mason, D. J. and Blain, E. J. 2018. Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non-invasive murine model of post-traumatic osteoarthritis. Journal of Orthopaedic Research 36(8), pp. 2118-2127. (10.1002/jor.23872)
• Blain, E. and Duance, V. 2018. Meniscus. In: Hutson, M. and Speed, C. eds. Sports Injuries. Oxford UK: Oxford University Press, pp. 45-53.

2016

• Al-Sabah, A., Stadnik, P., Gilbert, S., Duance, V. and Blain, E. 2016. Importance of reference gene selection for articular cartilage mechanobiology studies. Osteoarthritis and Cartilage 24(4), pp. 719-730. (10.1016/j.joca.2015.11.007)

2015

• Fu, Q. et al. 2015. Radiographic features of hand osteoarthritis in adult Kashin-Beck Disease (KBD): the Yongshou KBD study. Osteoarthritis and Cartilage 23(6), pp. 868-873. (10.1016/j.joca.2015.01.009)
• Chen, J. et al. 2015. Altered proteolytic activity and expression of mmps and aggrecanases and their inhibitors in Kashin-Beck disease. Journal of Orthopaedic Research 33(1), pp. 47-55. (10.1002/jor.22708)

2014

• Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5, article number: 174. (10.3389/fendo.2014.00174)
• Li, S., Blain, E. J., Cao, J., Caterson, B. and Duance, V. C. 2014. Effects of the mycotoxin nivalenol on bovine articular chondrocyte metabolism in vitro. PLoS ONE 9(10), article number: e109536. (10.1371/journal.pone.0109536)
• Gilbert, S. J., Meakin, L. B., Mason, D. J., Duance, V. C. and Blain, E. J. 2014. The use of a non-invasive murine knee joint loading model to identify mechano-regulated genes in vivo. International Journal of Experimental Pathology 95(3), pp. A11-A12. (10.1111/iep.12078)

2012

• Blain, E. J., Thomas, R. S. and Duance, V. C. 2012. Effect of Wnt3A on load-induced markers of chondrocyte matrix metabolism. International Journal of Experimental Pathology 93(4), pp. A13-A14. (10.1111/j.1365-2613.2012.00822.x)
• Gilbert, S. J., Blain, E. J., Al-Sabah, A., Zhang, Y., Duance, V. C. and Mason, D. J. 2012. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials 23, pp. 41-57.

2011

• Parsons, P. et al. 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
• Li, S., Jia, X., Duance, V. C. and Blain, E. J. 2011. The effects of cyclic tensile strain on the organisation and expression of cytoskeletal elements in bovine intervertebral disc cells: an in vitro study. European Cells and Materials 21, pp. 508-522.
• Khan, I. M. et al. 2011. Interleukin-1β enhances cartilage-to-cartilage integration. European Cells and Materials 22, pp. 190-201.
• Thomas, R. S., Clarke, A. R., Duance, V. C. and Blain, E. J. 2011. Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Research and Therapy 13(6), article number: R203. (10.1186/ar3536)
• Parsons, P. et al. 2011. Identification of a type IX collagen interaction with fibronectin: a molecular bridge in articular cartilage?. The Journal of Biological Chemistry 286(40), pp. 34986-34997. (10.1074/jbc.M111.238188)
• Blain, E. J. and Duance, V. C. 2011. Tissue injury and repair : meniscus. In: Hutson, M. and Speed, C. eds. Sports Injuries. Oxford: Oxford, pp. 45-53.

2010

• Blain, E. J., Ali, A. Y. and Duance, V. C. 2010. Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytotherapy Research 24(6), pp. 905-912. (10.1002/ptr.3055)
• Gilbert, S. J., Patel, M., Toumi, H., Duance, V. C. and Mason, D. J. 2010. Knockout of P58(IPK), a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint. International Journal of Experimental Pathology 91(2), pp. A34-A34. (10.1111/j.1365-2613.2009.00690.x)

2009

• Singhrao, S., Müller, C. T., Gilbert, S. J., Duance, V. C. and Archer, C. W. 2009. An immunofluorescence method for postembedded tissue in the acrylic resin Technovit 9100 New(R) using fluorescein isothiocyanate secondary detection. Microscopy Research and Technique 72(7), pp. 501-506. (10.1002/jemt.20705)
• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncostatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112. (10.1111/j.1365-2613.2008.00644.x)
• Singhrao, S. K., Müller, C. T., Gilbert, S. J., Duance, V. C. and Archer, C. W. 2009. An immunofluorescence method for post-embedded tissue in acrylic resin Technovit 9100 New(R) using fluorescein isothiocyanate secondary detection marker [Abstract]. International Journal of Experimental Pathology 90(2), pp. A129.
• Harrison, R. J., Blain, E. J., Wardale, R. J. and Duance, V. C. 2009. Involvement of the cytoskeleton in the regulation of articular chondrocyte phenotype in 3D-culture [Abstract]. International Journal of Experimental Pathology 90(2), pp. A112-A113. (10.1111/j.1365-2613.2008.00644.x)
• Li, S., Jia, X., Duance, V. C. and Blain, E. J. 2009. The effects of cyclic tensile strain on cytoskeleton in intervertebral disc cell: a preliminary study in vitro [Abstract]. International Journal of Experimental Pathology 90(2), pp. A120. (10.1111/j.1365-2613.2008.00644.x)
• Harrison, R. J., Blain, E. J., Wardale, R. J. and Duance, V. C. 2009. Comparison of gene expression of human chondrocytes in monolayer and 3D-culture [Abstract]. International Journal of Experimental Pathology 90(1), pp. A66. (10.1111/j.1365-2613.2008.00612.x)
• Gilbert, S. J. et al. 2009. Enhanced Tissue Integration During Cartilage Repair In Vitro Can Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge. Tissue Engineering :Part A 15(7), pp. 1739-1749. (10.1089/ten.tea.2008.0361)
• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2009. A pivotal role for protein kinase R in the oncastatin m and interleukin-1 induced catabolic phenotype in bovine articular cartilage chondrocytes. International Journal of Experimental Pathology 90(2), pp. A112-A112.
• Singhrao, S. ., Khan, I. M., Duance, V. C. and Archer, C. W. 2009. Biological responses of chondrocytes to poly(ethylene terephthalate)/polycaprolactone, (PET/PCL) co-polymer flat scaffolds as a potential biomaterial for matrix-induced autologous chondrocyte implantation (MACI) [Abstract]. International Journal of Experimental Pathology 90(1), pp. A68-A69. (10.1111/j.1365-2613.2008.00612.x)

2008

• Gilbert, S. J., Singhrao, S. K., Khan, I., Duance, V. C. and Archer, C. 2008. Inhibition of chondrocyte death at the wound edge enhances integrative cartilage repair. European Cells and Materials 16, pp. 26-39.
• Davies, L. C., Blain, E. J., Caterson, B. and Duance, V. C. 2008. Chondroitin sulphate impedes the migration of a sub-population of articular cartilage chondrocytes. Osteoarthritis and Cartilage 16(8), pp. 855-864. (10.1016/j.joca.2007.12.005)
• Gilbert, S. J., Blain, E. J., Duance, V. C. and Mason, D. J. 2008. Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58(1), pp. 209-220. (10.1002/art.23172)
• Gilbert, S. J., Singhrao, S. K., Khan, I. M., Duance, V. C. and Archer, C. W. 2008. Inhibiting chondrocyte death at the wound edge results in successful integrative cartilage repair in vitro. European Cells and Materials 16(Supp 3), pp. 55-55.
• Davies, L. C., Blain, E., Gilbert, S. J., Caterson, B. and Duance, V. 2008. The potential of IGF-1 and TGFβ1 for promoting “adult” articular cartilage repair: An in vitro study. Tissue Engineering Part A 14(7), pp. 1251-1261. (10.1089/ten.tea.2007.0211)
• Khan, I. M., Gilbert, S. J., Singhrao, S., Duance, V. C. and Archer, C. W. 2008. Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. (A review). European Cells & Materials 16, pp. 26-39.
• Li, S., Duance, V. C. and Blain, E. J. 2008. Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc. Journal of Anatomy 213(6), pp. 725-732. (10.1111/j.1469-7580.2008.00998.x)
• Vaughan-Thomas, A., Dudhia, J., Bayliss, M. T., Kadler, K. E. and Duance, V. C. 2008. Modification of the composition of articular cartilage collagen fibrils with increasing age. Connective Tissue Research 49(5), pp. 374-82. (10.1080/03008200802325417)

2007

• Blain, E. J., Li, S. and Duance, V. C. 2007. F-actin cytoskeletal organization in intervertebral disc health and disease. Biochemical Society Transactions 35(4), pp. 683-685. (10.1042/BST0350683)
• Fang, S. C., Coathup, M. J., Blunn, G. W., Caterson, B., Duance, V. C. and Freeman, M. A. 2007. Fracture healing and its potential as a bioreactor for skeletal tissue engineering. European Cells and Materials 13(Supp 2), pp. 28-29.

2006

• Blain, E. J., Gilbert, S. J., Hayes, A. J. and Duance, V. C. 2006. Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis.. Matrix biology 25(7), pp. 398-408. (10.1016/j.matbio.2006.06.002)
• Gilbert, S. J., Blain, E. J., Jones, P., Duance, V. C. and Mason, D. J. 2006. Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis research & therapy 8(4), article number: R89. (10.1186/ar1961)
• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2006. Protein kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2(1), pp. 9-21. (10.2174/157339706775697026)
• Blain, E. J. and Duance, V. C. 2006. Maintenance of chondrocyte phenotype by the vimentin intermediate filaments [Abstract]. European Cells and Materials 12(S. 1), pp. 53.
• Davies, L., Blain, E. J., Caterson, B. and Duance, V. C. 2006. Comparing the responsiveness of chondrocytes isolated from young and mature articular cartilage to IGF-1 and TGFβ1. European Cells and Materials 12(Supp 1), pp. 54-54.

2005

• Blain, E. J., Gilbert, S. J. and Duance, V. C. 2005. An intact cytoskeleton is essential to maintain articular cartilage chondrocyte metabolism. International Journal of Experimental Pathology 86(3), pp. A10-A11. (10.1111/j.0959-9673.2005.00426.x)

2004

• Davies, L. C., Caterson, B. and Duance, V. C. 2004. Novel strategies for enhancing tissue integration in cartilage repair. International Journal of Experimental Pathology 85(1), pp. A21-A22. (10.1111/j.0959-9673.2004.369aa.x)

2003

• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2003. Does protein kinase R mediate TNF-α- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism?. Arthritis Research & Therapy 6(1), pp. R46-R55. (10.1186/ar1024)
• Blain, E. J., Mason, D. J. and Duance, V. C. 2003. The effect of cyclical compressive loading on gene expression in articular cartilage. Biorheology 40(1-3), pp. 111-117.

2002

• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocytes. Biochemical Society Transactions 30(6), pp. 886-889. (10.1042/BST0300886)
• Blain, E. J., Mason, D. J. and Duance, V. C. 2002. The effect of thymosin β4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions 30(6), pp. 879-882. (10.1042/BST0300879)
• Young, R. D., Vaughan-Thomas, A., Wardale, R. J. and Duance, V. C. 2002. Type II collagen deposition in cruciate ligament precedes osteoarthritis in the guinea pig knee. Osteoarthritis and Cartilage 10(5), pp. 420-8. (10.1053/joca.2002.0530)
• Gilbert, S. J., Duance, V. C. and Mason, D. J. 2002. Tumour necrosis factor α up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-α in articular chondrocyte. Biochemical Society Transactions 30, pp. 886-889. (10.1042/bst0300886)

2001

• Blain, E. J., Gilbert, S. J., Wardale, R. J., Capper, S. J., Mason, D. J. and Duance, V. C. 2001. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Archives of biochemistry and biophysics 396(1), pp. 49-55. (10.1006/abbi.2001.2575)
• Vaughan-Thomas, A., Young, R. D., Phillips, A. C. and Duance, V. C. 2001. Characterization of type XI collagen-glycosaminoglycan interactions. The Journal of Biological Chemistry 276(7), pp. 5303-5309. (10.1074/jbc.M008764200)

2000

• Albon, J., Karwatowski, W. S., Easty, D. L., Sims, T. J. and Duance, V. C. 2000. Age related changes in the non-collagenous components of the extracellular matrix of the human lamina cribrosa. British Journal of Ophthalmology 84(3), pp. 311-317. (10.1136/bjo.84.3.311)
• Young, R. D., Lawrence, P. A., Duance, V. C., Aigner, T. and Monaghan, P. 2000. Immunolocalization of collagen Types II and III in single fibrils of human articular cartilage. Journal of Histochemistry and Cytochemistry 48(3), pp. 423-432. (10.1177/002215540004800312)
• Vaughan-Thomas, A., Gilbert, S. J. and Duance, V. 2000. Elevated levels of proteolytic enzymes in the aging human vitreous. Investigative Ophthalmology & Visual Science 41(11), pp. 3299-32304.
• Gilbert, S. J., Wotton, P. R., Bailey, A. J., Sims, T. J. and Duance, V. C. 2000. Alterations in the organisation, ultrastructure and biochemistry of the myocardial collagen matrix in Doberman pinschers with dilated cardiomyopathy. Research in Veterinary Science 69(3), pp. 267-274. (10.1053/rvsc.2000.0423)

1997

• Gilbert, S. J., Wotton, P. R., Tarlton, J. F., Duance, V. C. and Bailey, A. J. 1997. Increased expression of promatrix metalloproteinase-9 and neutrophil elastase in canine dilated cardiomyopathy. Cardiovascular Research 34(2), pp. 377-383. (10.1016/S0008-6363(97)00011-4)

1994

• Albon, J., Purslow, P. P., Duance, V. C., Easty, D. L. and Karwatowski, W. 1994. Mechanical compliance of the aging human lamina-cribrosa [Abstract]. Investigative Ophthalmology & Visual Science 35(4), pp. 1645-1645.