Professor Paul Kemp
Teams and roles for Paul Kemp
Emeritus Professor
School of Biosciences
Publication
2021
- Choompoo, N. et al. 2021. Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington disease. Cytotherapy 23(2), pp. 111-118. (10.1016/j.jcyt.2020.06.001)
2020
- Grimes, L., Griffiths, J., Pasqualetto, G., Brancale, A., Kemp, P. J., Young, M. T. and van der Goes van Naters, W. 2020. Drosophila taste neurons as an agonist-screening platform for P2X receptors. Scientific Reports 10, article number: 8292. (10.1038/s41598-020-65169-9)
- Smith-Geater, C. et al. 2020. Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation. Stem Cell Reports 14(3), pp. 406-419. (10.1016/j.stemcr.2020.01.015)
2019
- Garcia, V. J., Rushton, D. J., Tom, C. M., Allen, N. D., Kemp, P. J., Svendsen, C. N. and Mattis, V. B. 2019. Huntington's disease patient-derived astrocytes display electrophysiological impairments and reduced neuronal support. Frontiers in Neuroscience 13, article number: 669. (10.3389/fnins.2019.00669)
2018
- Telezhkin, V. et al. 2018. Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflügers Archiv European Journal of Physiology 470(9), pp. 1359-1376. (10.1007/s00424-018-2155-7)
2017
- Lim, R. G. et al. 2017. Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nature Neuroscience 20(5), pp. 648-660. (10.1038/nn.4532)
2016
- Kemp, P. J. et al. 2016. Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. The Journal of Physiology 594(22), pp. 6583-6594. (10.1113/JP270655)
- Stephen P., B., Telezhkin, V. and Kemp, P. 2016. Functional interactions between BKCa a-subunit and Annexin A5: implications in apoptosis. Oxidative Medicine and Cellular Longevity 2016, article number: 1607092. (10.1155/2016/1607092)
- Zhang, G., Edmundson, M., Telezhkin, V., Gu, Y., Wei, X., Kemp, P. J. and Song, B. 2016. The role of Kv1.2 channel in electrotaxis cell migration. Journal of Cellular Physiology 231(6), pp. 1375-1384. (10.1002/jcp.25259)
- Young, F. I. et al. 2016. Clonal heterogeneity in the neuronal and glial differentiation of dental pulp stem/progenitor cells. Stem Cells International 2016, article number: 1290561. (10.1155/2016/1290561)
- Telezhkin, V. et al. 2016. Forced cell-cycle exit and modulation of GABAA, CREB and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. American Journal of Physiology - Cell Physiology, article number: ajpcell.00166.2015. (10.1152/ajpcell.00166.2015)
- Yarova, P. L. et al. 2016. Inhaled calcilytics: effects on airway inflammation and remodeling. Respiratory Drug Delivery 1, pp. 1-12.
- Brennan, S. C. et al. 2016. The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR. Scientific Reports 6, article number: 21975. (10.1038/srep21975)
- Schepelmann, M. et al. 2016. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. American Journal of Physiology - Cell Physiology 310(3), pp. C193-C204. (10.1152/ajpcell.00248.2015)
2015
- Straccia, M. et al. 2015. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Molecular Therapy - Methods & Clinical Development 2, article number: 15030. (10.1038/mtm.2015.30)
- Hänggi, P. et al. 2015. Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells. American Journal of Physiology - Cell Physiology 308(12), pp. C993-C1007. (10.1152/ajpcell.00395.2014)
- Yarova, P. L. et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282)
2014
- Kemp, P. J. and Telezhkin, V. 2014. Oxygen sensing by the carotid body: is it all just rotten eggs?. Antioxidants & Redox Signaling 20(5), pp. 794-804. (10.1089/ars.2013.5377)
2013
- Lembrechts, R. et al. 2013. Functional expression of the multimodal extracellular calcium-sensing receptor in pulmonary neuroendocrine cells. Journal of Cell Science 126(19), pp. 4490-4501. (10.1242/jcs.131656)
- Matsa, E. et al. 2013. Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. European Heart Journal 35(16), pp. 1078-1087. (10.1093/eurheartj/eht067)
- Brennan, S. C. et al. 2013. Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels. PLoS ONE 8(11), pp. e80294. (10.1371/journal.pone.0080294)
- Shore, A., Karamitri, A., Kemp, P. J., Speakman, J. R., Graham, N. S. and Lomax, M. A. 2013. Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver. PLoS ONE 8(7), article number: e68933. (10.1371/journal.pone.0068933)
- Shore, A. et al. 2013. A Comparative approach to understanding tissue-specific expression of uncoupling protein 1 expression in adipose tissue. Frontiers in Genetics 3, article number: 304. (10.3389/fgene.2012.00304)
- Rushton, D. J., Mattis, V. B., Svendsen, C. N., Allen, N. D. and Kemp, P. J. 2013. Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons. PLoS ONE 8(11), pp. e81031. (10.1371/journal.pone.0081031)
2012
- Wray, S. et al. 2012. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS ONE 7(8), article number: e43099. (10.1371/journal.pone.0043099)
- Mattis, V. B. et al. 2012. Induced pluripotent stem cells from patients with Huntington's Disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11(2), pp. 264-278. (10.1016/j.stem.2012.04.027)
- Riccardi, D. and Kemp, P. J. 2012. The calcium-sensing receptor beyond extracellular calcium homeostasis: Conception, development, adult physiology, and disease. Annual Review of Physiology 74, pp. 271-297. (10.1146/annurev-physiol-020911-153318)
2011
- Wilkinson, W. J. and Kemp, P. J. 2011. Carbon monoxide: an emerging regulator of ion channels. The Journal of Physiology 589(13), pp. 3055-3062. (10.1113/jphysiol.2011.206706)
- Finney, B., Wilkinson, W. J., Searchfield, L., Cole, M., Bailey, S. L., Kemp, P. J. and Riccardi, D. 2011. An exon 5-less splice variant of the extracellular calcium-sensing receptor rescues absence of the full-length receptor in the developing mouse lung. Experimental Lung Research 37(5), pp. 269-278. (10.3109/01902148.2010.545471)
- Telezhkin, V., Brazier, S. P., Mears, R., Müller, C. T., Riccardi, D. and Kemp, P. J. 2011. Cysteine residue 911 in C-terminal tail of human BKCaα channel subunit is crucial for its activation by carbon monoxide. Pflugers Archiv-European Journal of Physiology 461(6), pp. 665-675. (10.1007/s00424-011-0924-7)
- Cayzac, S. H., Rocher, A., Obeso, A., Gonzalez, C., Riccardi, D. and Kemp, P. J. 2011. Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting L-type Ca2+ channels. Respiratory Physiology & Neurobiology 175(1), pp. 80-89. (10.1016/j.resp.2010.09.009)
- Wilkinson, W. J. and Kemp, P. J. 2011. The carbon monoxide donor, CORM-2, is an antagonist of ATP-gated, human P2X4 receptors. Purinergic Signalling 7(1), pp. 57-64. (10.1007/s11302-010-9213-8)
- Kelly, C. et al. 2011. Medical terminations of pregnancy: A viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation 20(4), pp. 503-513. (10.3727/096368910X546580)
- Wilkinson, W. J. et al. 2011. Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption. Pflügers Archiv European Journal of Physiology 462(2), pp. 267-279. (10.1007/s00424-011-0971-0)
2010
- Shore, A., Karamitri, A., Kemp, P. J., Speakman, J. R. and Lomax, M. A. 2010. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. Diabetologia 53(6), pp. 1164-1173. (10.1007/s00125-010-1701-4)
- Warburton, D. et al. 2010. Lung organogenesis. Current Topics in Developmental Biology 90, pp. 73-158. (10.1016/S0070-2153(10)90003-3)
- Telezhkin, V., Brazier, S. P., Cayzac, S. H., Wilkinson, W. J., Riccardi, D. and Kemp, P. J. 2010. Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels. Respiratory Physiology & Neurobiology 172(3), pp. 169-178. (10.1016/j.resp.2010.05.016)
2009
- Wilkinson, W. J., Gadeberg, H., Harrison, A. W. J., Allen, N. D., Riccardi, D. and Kemp, P. J. 2009. Carbon monoxide is a rapid modulator of recombinant and native P2X(2) ligand-gated ion channels. British Journal of Pharmacology 158(3), pp. 862-871. (10.1111/j.1476-5381.2009.00354.x)
- Kemp, P. J. et al. 2009. Enzyme-linked oxygen sensing by potassium channels. Annals of the New York Academy of Sciences 1177, pp. 112-118. (10.1111/j.1749-6632.2009.05025.x)
- Brazier, S. P., Telezhkin, V., Mears, R., Müller, T., Riccardi, D. and Kemp, P. J. 2009. Cysteine residues in the C-terminal tail of the human BKCaα subunit are important for channel sensitivity to carbon monoxide. Presented at: International Society of Arterial Chemoreception. 17th Meeting, Valladolid, Spain, 1-5 July 2008Arterial Chemoreceptors. Advances in Experimental Medicine and Biology Vol. 648. Netherlands: Springer Netherlands pp. 49-56., (10.1007/978-90-481-2259-2_5)
- Telezhin, V., Brazier, S. P., Cayzac, S., Müller, C. T., Riccardi, D. and Kemp, P. J. 2009. Hydrogen Sulfide inhibits human BKCa channels. Advances in Experimental Medicine and Biology 648, pp. 65-72. (10.1007/978-90-481-2259-2_7)
- Riccardi, D., Finney, B. A., Wilkinson, W. J. and Kemp, P. J. 2009. Novel regulatory aspects of the extracellular Ca2+-sensing receptor, CaR. Pflugers Archiv-European Journal of Physiology 458(6), pp. 1007-1022. (10.1007/s00424-009-0681-z)
- De Proost, I. et al. 2009. Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. The FASEB Journal 23(4), pp. 1153-1160. (10.1096/fj.08-109579)
- Cayzac, S., Rocher, A., Obeso, A., Gonzalez, C., Kemp, P. J. and Riccardi, D. 2009. Effects of the polyamine spermine on arterial chemoreception. Presented at: International Society of Arterial Chemoreception. 17th Meeting, Valladolid, Spain, 1-5 July 2008 Presented at Gonzalez, C., Nurse, C. A. and Peers, C. eds.Arterial chemoreceptors. Advances in Experimental Medicine and Biology Vol. 648. Netherlands: Springer Netherlands pp. 97-104., (10.1007/978-90-481-2259-2_11)
- Kemp, P. J. and Peers, C. 2009. Enzyme-linked acute oxygen sensing in airway and arterial chemoreceptors. In: Gonzalez, C., Nurse, C. A. and Peers, C. eds. Arterial Chemoreceptors. Advances in Experimental Medicine and Biology Vol. 648. Netherlands: Springer Netherlands, pp. 39-48., (10.1007/978-90-481-2259-2_4)
2008
- Finney, B. et al. 2008. Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. Journal of Physiology 586(24), pp. 6007-6019. (10.1113/jphysiol.2008.161687)
- De Proost, I. et al. 2008. Functional live cell imaging of the pulmonary neuroepithelial body microenvironment. American Journal of Respiratory Cell and Molecular Biology 39(2), pp. 180-189. (10.1165/rcmb.2008-0011OC)
- Williams, S. E., Brazier, S. P., Baban, N., Telezhkin, V., Muller, C. T., Riccardi, D. and Kemp, P. J. 2008. A structural motif in the C-terminal tail of slo1 confers carbon monoxide sensitivity to human BKCa channels. Pflugers Archiv-European Journal of Physiology 456(3), pp. 561-572. (10.1007/s00424-007-0439-4)
- Timmermans, J. P. et al. 2008. Expression of P2X receptors in LAD-2 cells and human lung mast cells [Abstract]. Purinergic Signalling 4(S1), pp. S159. (10.1007/s11302-008-9116-0)
- Wilkinson, W. J., Hanne, G., Harrison, A. W. J., Allen, N. D., Riccardi, D. and Kemp, P. J. 2008. Carbon monoxide is a rapid modulator of recombinant and native P2X2 ligand-gated ion channels [Abstract]. Purinergic Signalling 4(S1), pp. 26. (10.1007/s11302-008-9116-0)
2007
- Dvorak, M. M. et al. 2007. Thiazide Diuretics Directly Induce Osteoblast Differentiation and Mineralized Nodule Formation by Interacting with a Sodium Chloride Co-Transporter in Bone. Journal of the American Society of Nephrology 18(9), pp. 2509-2516. (10.1681/ASN.2007030348)
- Kemp, P. J. and Peers, C. 2007. Oxygen sensing by ion channels. Essays in Biochemistry 43, pp. 77-90. (10.1042/bse0430077)
- Joannides, A. J. et al. 2007. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain 130(5), pp. 1263-1275. (10.1093/brain/awm070)
2006
- Kemp, P. J., Peers, C., Riccardi, D., Iles, D. E., Mason, H. S., Wootton, P. and Williams, S. E. 2006. In search of the acute oxygen sensor: Functional proteomics and acute regulation of large-conductance, calcium-activated potassium channels by hemeoxygenase-2. In: Hayashida, Y., Gonzalez, C. and Kondo, H. eds. The Arterial Chemoreceptors., Vol. 580. Advances in Experimental Medicine and Biology Springer, pp. 137-146., (10.1007/0-387-31311-7_21)
- Duchen, M. et al. 2006. Discussion. Novartis Foundation Symposium 272, pp. 100-105.
- Kummer, W. et al. 2006. Discussion. Novartis Foundation Symposium 272, pp. 114-118.
- Peers, C., Kemp, P. J., Boyle, J. P., Porter, K. E., Pearson, H. A., Smith, I. F. and Kemp, P. J. 2006. Hypoxic regulation of Ca2+ signalling in astrocytes and endothelial cells. In: Chadwick, D. and Goode, J. eds. Signalling Pathways in Acute Oxygen Sensing: Novartis Foundation Symposium 272. Wiley-Blackwell, pp. 119-127., (10.1002/9780470035009.ch10)
- Kemp, P. J., Williams, S. E. J., Mason, H. S., Wootton, P., Iles, D. E., Riccardi, D. and Peers, C. 2006. General discussion II. Novartis Foundation Symposium(272), pp. 131-140.
- Peers, C., Kang, P., Boyle, J. P., Porter, K. E., Pearson, H. A., Smith, I. F. and Kemp, P. J. 2006. General discussion I. Novartis Foundation Symposium(272), pp. 33-36.
- Kemp, P. J. 2006. Detecting acute changes in oxygen: will the real sensor please stand up?. Experimental Physiology 91(5), pp. 829-834. (10.1113/expphysiol.2006.034587)
- Kemp, P. J., Williams, S. E., Mason, H. S., Wootton, P., Iles, D. E., Riccardi, D. and Peers, C. 2006. Functional proteomics of BK potassium channels: Defining the acute oxygen sensor. In: Chadwick, D. J. and Goode, J. eds. Signalling Pathways in Acute Oxygen Sensing: Novartis Foundation Symposium 272. Novartis Foundation Symposia Wiley-Blackwell, pp. 141-151., (10.1002/9780470035009.ch12)
- Buckler, K. J. et al. 2006. Discussion. Novartis Foundation Symposium 272, pp. 228-233.
- Chandel, N. S. et al. 2006. Discussion. Novartis Foundation Symposium 272, pp. 151-156.
- Kemp, P. J. et al. 2006. General discussion III. Novartis Foundation Symposium 272, pp. 214-217.
- Peers, C., Aley, P. K., Boyle, J. P., Porter, K. E., Pearson, H. A., Smith, I. F. and Kemp, P. J. 2006. Hypoxic regulation of Ca2+ signalling in astrocytes and endothelial cells. In: Hayashida, Y., Gonzalez, C. and Konda, H. eds. The Arterial Chemoreceptors., Vol. 580. Advances in Experimental Medicine and Biology Kluwer, pp. 185-190., (10.1007/0-387-31311-7_28)
- Joannides, A. J. et al. 2006. A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Stem Cells 25(3), pp. 731-737. (10.1634/stemcells.2006-0562)
2005
- Aley, P. K., Porter, K. E., Boyle, J. P., Kemp, P. J. and Peers, C. 2005. Hypoxic modulation of Ca2+ signaling in human venous endothelial cells: MULTIPLE ROLES FOR REACTIVE OXYGEN SPECIES. Journal of Biological Chemistry 280(14), pp. 13349-13354. (10.1074/jbc.M413674200)
- Miller, P., Kemp, P. J. and Peers, C. 2005. Structural requirements for O2 sensing by the human tandem-P domain channel, hTREK1. Biochemical and Biophysical Research Communications 331(4), pp. 1253-1256. (10.1016/j.bbrc.2005.04.042)
- Brazier, S. P., Mason, H. S., Bateson, A. N. and Kemp, P. J. 2005. Cloning of the human TASK-2 (KCNK5) promoter and its regulation by chronic hypoxia. Biochemical and Biophysical Research Communications 336(4), pp. 1251-1258. (10.1016/j.bbrc.2005.09.007)
- Kemp, P. J. 2005. Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction. Biochemical and Biophysical Research Communications 338(1), pp. 648-652. (10.1016/j.bbrc.2005.08.110)
- Bourke, S., Mason, H. S., Borok, Z., Kim, K., Crandall, E. D. and Kemp, P. J. 2005. Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells. Respiratory Research 6, article number: 40. (10.1186/1465-9921-6-40)
2004
- Williams, S. E. J. et al. 2004. Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science, pp. 2993-2997. (10.1126/science.1105010)
- Miller, P., Peers, C. and Kemp, P. J. 2004. Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: Physiological impact in acidosis and alkalosis. American Journal of Physiology - Cell Physiology 286(2), pp. C272-C282. (10.1152/ajpcell.00334.2003)
- Kemp, P. J., Peers, C., Lewis, A. and Miller, P. 2004. Regulation of recombinant human brain tandem P domain K+ channels by hypoxia: A role for O2 in the control of neuronal excitability?. Journal of Cellular and Molecular Medicine 8(1), pp. 38-44. (10.1111/j.1582-4934.2004.tb00258.x)
- Mason, H. S., Bourke, S. and Kemp, P. J. 2004. Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species. Molecular Pharmacology 66(6), pp. 1525-1535. (10.1124/mol.104.000851)
- Peers, C. and Kemp, P. J. 2004. Ion channel regulation by chronic hypoxia in models of acute oxygen sensing. Cell Calcium 36(3-4), pp. 341-348. (10.1016/j.ceca.2004.02.005)
- Kemp, P. J. and Kim, K. 2004. Spectrum of ion channels in alveolar epithelial cells: implications for alveolar fluid balance. AJP: Lung Cellular and Molecular Physiology 287(3), pp. L460-L464. (10.1152/ajplung.00191.2004)
- Kemp, P. J. and Peers, C. 2004. Assessment of oxygen sensing by model airway and arterial chemoreceptors. Methods in Enzymology 381, pp. 3-25. (10.1016/S0076-6879(04)81001-2)
- Kemp, P. J., Iles, D. and Peers, C. 2004. Oxygen sensing by human recombinant K+ channels: assessment of the use of stable cell lines. Methods in Enzymology 381, pp. 257-274. (10.1016/S0076-6879(04)81018-8)
- Hammond, L. C., Bonnet, C., Kemp, P. J., Yates, M. S. and Bowmer, C. J. 2004. Chronic hypoxia up-regulates expression of adenosine A1 receptors in DDT1-MF2 cells. Biochemical Pharmacology 67(3), pp. 421-426. (10.1016/j.bcp.2003.09.003)
- Williams, S. E., Wootton, P., Mason, H. S., Iles, D. E., Peers, C. and Kemp, P. J. 2004. siRNA knock-down of γ-glutamyl transpeptidase does not affect hypoxic K+ channel inhibition. Biochemical and Biophysical Research Communications 314(1), pp. 63-68. (10.1016/j.bbrc.2003.12.052)
2003
- Hartness, M. E., Brazier, S. P., Peers, C., Bateson, A. N., Ashford, M. L. and Kemp, P. J. 2003. Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia. Journal of Biological Chemistry, pp. 51422-51432. (10.1074/jbc.M309463200)
- Kemp, P. J. et al. 2003. Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies. Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology 270A(1), pp. 41-50. (10.1002/ar.a.10008)
- Kemp, P. J., Peers, C. and Lewis, A. 2003. Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels. Regulation by acute hypoxia. Advances in Experimental Medicine and Biology 536, pp. 209-215.
- Miller, P., Kemp, P. J., Lewis, A., Chapman, C. G., Meadows, H. J. and Peers, C. 2003. Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K+ channels in central neuroprotection. The Journal of Physiology 548(1), pp. 31-37. (10.1113/jphysiol.2003.040048)
2002
- Lewis, A., Peers, C., Ashford, M. L. J. and Kemp, P. J. 2002. Hypoxia inhibits human recombinant large conductance, Ca2+-activated K+ (maxi-K) channels by a mechanism which is membrane delimited and Ca2+ sensitive. The Journal of Physiology 540(3), pp. 771-780. (10.1113/jphysiol.2001.013888)
- Colebrooke, R. L., Smith, I. F., Kemp, P. J. and Peers, C. 2002. Chronic hypoxia remodels voltage-gated Ca2+ entry in a human airway chemoreceptor cell line. Neuroscience Letters 318(2), pp. 69-72. (10.1016/S0304-3940(01)02479-X)
- Plant, L. D., Kemp, P. J., Peers, C., Henderson, Z. and Pearson, H. A. 2002. Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1. Stroke 33(9), pp. 2324-2328. (10.1161/01.STR.0000027440.68031.B0)
- Searle, G. J., Hartness, M. E., Hoareau, R., Peers, C. and Kemp, P. J. 2002. Lack of contribution of mitochondrial electron transport to acute O2 sensing in model airway chemoreceptors. Biochemical and Biophysical Research Communications 291(2), pp. 332-337. (10.1006/bbrc.2002.6428)
- Kemp, P. J., Peers, C., Miller, P. and Lewis, A. 2002. Oxygen sensing by human recombinant tandem-P domain potassium channels. In: Pequinot, J. et al. eds. Chemoreception: From Cellular Signaling to Functional Plasticity. Advances in Experimental Medicine and Biology Springer, pp. 201-208., (10.1007/978-1-4419-9280-2_26)
- Kemp, P. J., Hartness, M. E. and Peers, C. 2002. Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels:regulation by chronic hypoxia. In: Pequignot, J. et al. eds. Chemoreception: From Cellular Signaling to Functional Plasticity. Advances in Experimental Medicine and Biology Springer, pp. 573-581.
- Kemp, P. J., Lewis, A., Hartness, M. E., Searle, G. J., Miller, P., O'Kelly, I. and Peers, C. 2002. Airway chemotransduction: from oxygen sensor to cellular effector. American Journal of Respiratory and Critical Care Medicine 166, pp. S17-S24. (10.1164/rccm.2206009)
2001
- Hartness, M. E., Lewis, A., Searle, G. J., O'Kelly, I., Peers, C. and Kemp, P. J. 2001. Combined antisense and pharmacological approaches implicate hTASK as an airway O2-sensing K+ channel. Journal of Biological Chemistry, pp. 26499-26508. (10.1074/jbc.M010357200)
- Baines, D. L., MacGregor, G. G. and Kemp, P. J. 2001. Fatty acid modulation and sequence identity of fetal guinea pig alveolar type II cell amiloride-sensitive Na+ channel. Biochemical and Biophysical Research Communications 288(3), pp. 727-735. (10.1006/bbrc.2001.5828)
- Kemp, P. J., Kim, K., Borok, Z. and Crandall, E. D. 2001. Re-evaluating the Na+ conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels. The Journal of Physiology 536(3), pp. 693-701. (10.1111/j.1469-7793.2001.t01-1-00693.x)
- O'Kelly, I., Peers, C. and Kemp, P. J. 2001. NADPH oxidase does not account fully for O2-Sensing in model airway chemoreceptor cells. Biochemical and Biophysical Research Communications 283(5), pp. 1131-1134. (10.1006/bbrc.2001.4919)
- Lewis, A., Hartness, M. E., Chapman, C. G., Fearon, I. M., Meadows, H. J., Peers, C. and Kemp, P. J. 2001. Recombinant hTASK1 Is an O2-sensitive K+ channel. Biochemical and Biophysical Research Communications 285(5), pp. 1290-1294. (10.1006/bbrc.2001.5310)
- Peers, C. and Kemp, P. J. 2001. Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors. Respiratory Research 2, pp. 145-149. (10.1186/rr51)
2000
- O'Kelly, I., Lewis, A. and Kemp, P. J. 2000. O2 Sensing by Airway Chemoreceptor-derived cells protein kinase C activation reveals functional evidence for involvement of NADPH oxidase. Journal of Biological Chemistry 275(11), pp. 7684-7692. (10.1074/jbc.275.11.7684)
- Kemp, P. J., Peers, C., Miller, P. and Lewis, A. 2000. O2-sensing by model airway chemoreceptors: hypoxic inhibition of K+ channels in H146 cells. In: Pequignot, J. et al. eds. Chemoreception: From Cellular Signaling to Functional Plasticity. Advances in Experimental Medicine and Biology Springer, pp. 611-622., (10.1007/978-1-4419-9280-2_26)
Articles
- Choompoo, N. et al. 2021. Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington disease. Cytotherapy 23(2), pp. 111-118. (10.1016/j.jcyt.2020.06.001)
- Grimes, L., Griffiths, J., Pasqualetto, G., Brancale, A., Kemp, P. J., Young, M. T. and van der Goes van Naters, W. 2020. Drosophila taste neurons as an agonist-screening platform for P2X receptors. Scientific Reports 10, article number: 8292. (10.1038/s41598-020-65169-9)
- Smith-Geater, C. et al. 2020. Aberrant development corrected in adult-onset Huntington's disease iPSC-derived neuronal cultures via WNT signaling modulation. Stem Cell Reports 14(3), pp. 406-419. (10.1016/j.stemcr.2020.01.015)
- Garcia, V. J., Rushton, D. J., Tom, C. M., Allen, N. D., Kemp, P. J., Svendsen, C. N. and Mattis, V. B. 2019. Huntington's disease patient-derived astrocytes display electrophysiological impairments and reduced neuronal support. Frontiers in Neuroscience 13, article number: 669. (10.3389/fnins.2019.00669)
- Telezhkin, V. et al. 2018. Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflügers Archiv European Journal of Physiology 470(9), pp. 1359-1376. (10.1007/s00424-018-2155-7)
- Lim, R. G. et al. 2017. Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice. Nature Neuroscience 20(5), pp. 648-660. (10.1038/nn.4532)
- Kemp, P. J. et al. 2016. Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. The Journal of Physiology 594(22), pp. 6583-6594. (10.1113/JP270655)
- Stephen P., B., Telezhkin, V. and Kemp, P. 2016. Functional interactions between BKCa a-subunit and Annexin A5: implications in apoptosis. Oxidative Medicine and Cellular Longevity 2016, article number: 1607092. (10.1155/2016/1607092)
- Zhang, G., Edmundson, M., Telezhkin, V., Gu, Y., Wei, X., Kemp, P. J. and Song, B. 2016. The role of Kv1.2 channel in electrotaxis cell migration. Journal of Cellular Physiology 231(6), pp. 1375-1384. (10.1002/jcp.25259)
- Young, F. I. et al. 2016. Clonal heterogeneity in the neuronal and glial differentiation of dental pulp stem/progenitor cells. Stem Cells International 2016, article number: 1290561. (10.1155/2016/1290561)
- Telezhkin, V. et al. 2016. Forced cell-cycle exit and modulation of GABAA, CREB and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons. American Journal of Physiology - Cell Physiology, article number: ajpcell.00166.2015. (10.1152/ajpcell.00166.2015)
- Yarova, P. L. et al. 2016. Inhaled calcilytics: effects on airway inflammation and remodeling. Respiratory Drug Delivery 1, pp. 1-12.
- Brennan, S. C. et al. 2016. The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR. Scientific Reports 6, article number: 21975. (10.1038/srep21975)
- Schepelmann, M. et al. 2016. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. American Journal of Physiology - Cell Physiology 310(3), pp. C193-C204. (10.1152/ajpcell.00248.2015)
- Straccia, M. et al. 2015. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Molecular Therapy - Methods & Clinical Development 2, article number: 15030. (10.1038/mtm.2015.30)
- Hänggi, P. et al. 2015. Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells. American Journal of Physiology - Cell Physiology 308(12), pp. C993-C1007. (10.1152/ajpcell.00395.2014)
- Yarova, P. L. et al. 2015. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine 7(284), article number: 284ra60. (10.1126/scitranslmed.aaa0282)
- Kemp, P. J. and Telezhkin, V. 2014. Oxygen sensing by the carotid body: is it all just rotten eggs?. Antioxidants & Redox Signaling 20(5), pp. 794-804. (10.1089/ars.2013.5377)
- Lembrechts, R. et al. 2013. Functional expression of the multimodal extracellular calcium-sensing receptor in pulmonary neuroendocrine cells. Journal of Cell Science 126(19), pp. 4490-4501. (10.1242/jcs.131656)
- Matsa, E. et al. 2013. Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. European Heart Journal 35(16), pp. 1078-1087. (10.1093/eurheartj/eht067)
- Brennan, S. C. et al. 2013. Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels. PLoS ONE 8(11), pp. e80294. (10.1371/journal.pone.0080294)
- Shore, A., Karamitri, A., Kemp, P. J., Speakman, J. R., Graham, N. S. and Lomax, M. A. 2013. Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver. PLoS ONE 8(7), article number: e68933. (10.1371/journal.pone.0068933)
- Shore, A. et al. 2013. A Comparative approach to understanding tissue-specific expression of uncoupling protein 1 expression in adipose tissue. Frontiers in Genetics 3, article number: 304. (10.3389/fgene.2012.00304)
- Rushton, D. J., Mattis, V. B., Svendsen, C. N., Allen, N. D. and Kemp, P. J. 2013. Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons. PLoS ONE 8(11), pp. e81031. (10.1371/journal.pone.0081031)
- Wray, S. et al. 2012. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS ONE 7(8), article number: e43099. (10.1371/journal.pone.0043099)
- Mattis, V. B. et al. 2012. Induced pluripotent stem cells from patients with Huntington's Disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11(2), pp. 264-278. (10.1016/j.stem.2012.04.027)
- Riccardi, D. and Kemp, P. J. 2012. The calcium-sensing receptor beyond extracellular calcium homeostasis: Conception, development, adult physiology, and disease. Annual Review of Physiology 74, pp. 271-297. (10.1146/annurev-physiol-020911-153318)
- Wilkinson, W. J. and Kemp, P. J. 2011. Carbon monoxide: an emerging regulator of ion channels. The Journal of Physiology 589(13), pp. 3055-3062. (10.1113/jphysiol.2011.206706)
- Finney, B., Wilkinson, W. J., Searchfield, L., Cole, M., Bailey, S. L., Kemp, P. J. and Riccardi, D. 2011. An exon 5-less splice variant of the extracellular calcium-sensing receptor rescues absence of the full-length receptor in the developing mouse lung. Experimental Lung Research 37(5), pp. 269-278. (10.3109/01902148.2010.545471)
- Telezhkin, V., Brazier, S. P., Mears, R., Müller, C. T., Riccardi, D. and Kemp, P. J. 2011. Cysteine residue 911 in C-terminal tail of human BKCaα channel subunit is crucial for its activation by carbon monoxide. Pflugers Archiv-European Journal of Physiology 461(6), pp. 665-675. (10.1007/s00424-011-0924-7)
- Cayzac, S. H., Rocher, A., Obeso, A., Gonzalez, C., Riccardi, D. and Kemp, P. J. 2011. Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting L-type Ca2+ channels. Respiratory Physiology & Neurobiology 175(1), pp. 80-89. (10.1016/j.resp.2010.09.009)
- Wilkinson, W. J. and Kemp, P. J. 2011. The carbon monoxide donor, CORM-2, is an antagonist of ATP-gated, human P2X4 receptors. Purinergic Signalling 7(1), pp. 57-64. (10.1007/s11302-010-9213-8)
- Kelly, C. et al. 2011. Medical terminations of pregnancy: A viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation 20(4), pp. 503-513. (10.3727/096368910X546580)
- Wilkinson, W. J. et al. 2011. Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption. Pflügers Archiv European Journal of Physiology 462(2), pp. 267-279. (10.1007/s00424-011-0971-0)
- Shore, A., Karamitri, A., Kemp, P. J., Speakman, J. R. and Lomax, M. A. 2010. Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. Diabetologia 53(6), pp. 1164-1173. (10.1007/s00125-010-1701-4)
- Warburton, D. et al. 2010. Lung organogenesis. Current Topics in Developmental Biology 90, pp. 73-158. (10.1016/S0070-2153(10)90003-3)
- Telezhkin, V., Brazier, S. P., Cayzac, S. H., Wilkinson, W. J., Riccardi, D. and Kemp, P. J. 2010. Mechanism of inhibition by hydrogen sulfide of native and recombinant BKCa channels. Respiratory Physiology & Neurobiology 172(3), pp. 169-178. (10.1016/j.resp.2010.05.016)
- Wilkinson, W. J., Gadeberg, H., Harrison, A. W. J., Allen, N. D., Riccardi, D. and Kemp, P. J. 2009. Carbon monoxide is a rapid modulator of recombinant and native P2X(2) ligand-gated ion channels. British Journal of Pharmacology 158(3), pp. 862-871. (10.1111/j.1476-5381.2009.00354.x)
- Kemp, P. J. et al. 2009. Enzyme-linked oxygen sensing by potassium channels. Annals of the New York Academy of Sciences 1177, pp. 112-118. (10.1111/j.1749-6632.2009.05025.x)
- Telezhin, V., Brazier, S. P., Cayzac, S., Müller, C. T., Riccardi, D. and Kemp, P. J. 2009. Hydrogen Sulfide inhibits human BKCa channels. Advances in Experimental Medicine and Biology 648, pp. 65-72. (10.1007/978-90-481-2259-2_7)
- Riccardi, D., Finney, B. A., Wilkinson, W. J. and Kemp, P. J. 2009. Novel regulatory aspects of the extracellular Ca2+-sensing receptor, CaR. Pflugers Archiv-European Journal of Physiology 458(6), pp. 1007-1022. (10.1007/s00424-009-0681-z)
- De Proost, I. et al. 2009. Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. The FASEB Journal 23(4), pp. 1153-1160. (10.1096/fj.08-109579)
- Finney, B. et al. 2008. Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. Journal of Physiology 586(24), pp. 6007-6019. (10.1113/jphysiol.2008.161687)
- De Proost, I. et al. 2008. Functional live cell imaging of the pulmonary neuroepithelial body microenvironment. American Journal of Respiratory Cell and Molecular Biology 39(2), pp. 180-189. (10.1165/rcmb.2008-0011OC)
- Williams, S. E., Brazier, S. P., Baban, N., Telezhkin, V., Muller, C. T., Riccardi, D. and Kemp, P. J. 2008. A structural motif in the C-terminal tail of slo1 confers carbon monoxide sensitivity to human BKCa channels. Pflugers Archiv-European Journal of Physiology 456(3), pp. 561-572. (10.1007/s00424-007-0439-4)
- Timmermans, J. P. et al. 2008. Expression of P2X receptors in LAD-2 cells and human lung mast cells [Abstract]. Purinergic Signalling 4(S1), pp. S159. (10.1007/s11302-008-9116-0)
- Wilkinson, W. J., Hanne, G., Harrison, A. W. J., Allen, N. D., Riccardi, D. and Kemp, P. J. 2008. Carbon monoxide is a rapid modulator of recombinant and native P2X2 ligand-gated ion channels [Abstract]. Purinergic Signalling 4(S1), pp. 26. (10.1007/s11302-008-9116-0)
- Dvorak, M. M. et al. 2007. Thiazide Diuretics Directly Induce Osteoblast Differentiation and Mineralized Nodule Formation by Interacting with a Sodium Chloride Co-Transporter in Bone. Journal of the American Society of Nephrology 18(9), pp. 2509-2516. (10.1681/ASN.2007030348)
- Kemp, P. J. and Peers, C. 2007. Oxygen sensing by ion channels. Essays in Biochemistry 43, pp. 77-90. (10.1042/bse0430077)
- Joannides, A. J. et al. 2007. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain 130(5), pp. 1263-1275. (10.1093/brain/awm070)
- Duchen, M. et al. 2006. Discussion. Novartis Foundation Symposium 272, pp. 100-105.
- Kummer, W. et al. 2006. Discussion. Novartis Foundation Symposium 272, pp. 114-118.
- Kemp, P. J., Williams, S. E. J., Mason, H. S., Wootton, P., Iles, D. E., Riccardi, D. and Peers, C. 2006. General discussion II. Novartis Foundation Symposium(272), pp. 131-140.
- Peers, C., Kang, P., Boyle, J. P., Porter, K. E., Pearson, H. A., Smith, I. F. and Kemp, P. J. 2006. General discussion I. Novartis Foundation Symposium(272), pp. 33-36.
- Kemp, P. J. 2006. Detecting acute changes in oxygen: will the real sensor please stand up?. Experimental Physiology 91(5), pp. 829-834. (10.1113/expphysiol.2006.034587)
- Buckler, K. J. et al. 2006. Discussion. Novartis Foundation Symposium 272, pp. 228-233.
- Chandel, N. S. et al. 2006. Discussion. Novartis Foundation Symposium 272, pp. 151-156.
- Kemp, P. J. et al. 2006. General discussion III. Novartis Foundation Symposium 272, pp. 214-217.
- Joannides, A. J. et al. 2006. A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Stem Cells 25(3), pp. 731-737. (10.1634/stemcells.2006-0562)
- Aley, P. K., Porter, K. E., Boyle, J. P., Kemp, P. J. and Peers, C. 2005. Hypoxic modulation of Ca2+ signaling in human venous endothelial cells: MULTIPLE ROLES FOR REACTIVE OXYGEN SPECIES. Journal of Biological Chemistry 280(14), pp. 13349-13354. (10.1074/jbc.M413674200)
- Miller, P., Kemp, P. J. and Peers, C. 2005. Structural requirements for O2 sensing by the human tandem-P domain channel, hTREK1. Biochemical and Biophysical Research Communications 331(4), pp. 1253-1256. (10.1016/j.bbrc.2005.04.042)
- Brazier, S. P., Mason, H. S., Bateson, A. N. and Kemp, P. J. 2005. Cloning of the human TASK-2 (KCNK5) promoter and its regulation by chronic hypoxia. Biochemical and Biophysical Research Communications 336(4), pp. 1251-1258. (10.1016/j.bbrc.2005.09.007)
- Kemp, P. J. 2005. Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction. Biochemical and Biophysical Research Communications 338(1), pp. 648-652. (10.1016/j.bbrc.2005.08.110)
- Bourke, S., Mason, H. S., Borok, Z., Kim, K., Crandall, E. D. and Kemp, P. J. 2005. Development of a lung slice preparation for recording ion channel activity in alveolar epithelial type I cells. Respiratory Research 6, article number: 40. (10.1186/1465-9921-6-40)
- Williams, S. E. J. et al. 2004. Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science, pp. 2993-2997. (10.1126/science.1105010)
- Miller, P., Peers, C. and Kemp, P. J. 2004. Polymodal regulation of hTREK1 by pH, arachidonic acid, and hypoxia: Physiological impact in acidosis and alkalosis. American Journal of Physiology - Cell Physiology 286(2), pp. C272-C282. (10.1152/ajpcell.00334.2003)
- Kemp, P. J., Peers, C., Lewis, A. and Miller, P. 2004. Regulation of recombinant human brain tandem P domain K+ channels by hypoxia: A role for O2 in the control of neuronal excitability?. Journal of Cellular and Molecular Medicine 8(1), pp. 38-44. (10.1111/j.1582-4934.2004.tb00258.x)
- Mason, H. S., Bourke, S. and Kemp, P. J. 2004. Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species. Molecular Pharmacology 66(6), pp. 1525-1535. (10.1124/mol.104.000851)
- Peers, C. and Kemp, P. J. 2004. Ion channel regulation by chronic hypoxia in models of acute oxygen sensing. Cell Calcium 36(3-4), pp. 341-348. (10.1016/j.ceca.2004.02.005)
- Kemp, P. J. and Kim, K. 2004. Spectrum of ion channels in alveolar epithelial cells: implications for alveolar fluid balance. AJP: Lung Cellular and Molecular Physiology 287(3), pp. L460-L464. (10.1152/ajplung.00191.2004)
- Kemp, P. J. and Peers, C. 2004. Assessment of oxygen sensing by model airway and arterial chemoreceptors. Methods in Enzymology 381, pp. 3-25. (10.1016/S0076-6879(04)81001-2)
- Kemp, P. J., Iles, D. and Peers, C. 2004. Oxygen sensing by human recombinant K+ channels: assessment of the use of stable cell lines. Methods in Enzymology 381, pp. 257-274. (10.1016/S0076-6879(04)81018-8)
- Hammond, L. C., Bonnet, C., Kemp, P. J., Yates, M. S. and Bowmer, C. J. 2004. Chronic hypoxia up-regulates expression of adenosine A1 receptors in DDT1-MF2 cells. Biochemical Pharmacology 67(3), pp. 421-426. (10.1016/j.bcp.2003.09.003)
- Williams, S. E., Wootton, P., Mason, H. S., Iles, D. E., Peers, C. and Kemp, P. J. 2004. siRNA knock-down of γ-glutamyl transpeptidase does not affect hypoxic K+ channel inhibition. Biochemical and Biophysical Research Communications 314(1), pp. 63-68. (10.1016/j.bbrc.2003.12.052)
- Hartness, M. E., Brazier, S. P., Peers, C., Bateson, A. N., Ashford, M. L. and Kemp, P. J. 2003. Post-transcriptional control of human maxiK potassium channel activity and acute oxygen sensitivity by chronic hypoxia. Journal of Biological Chemistry, pp. 51422-51432. (10.1074/jbc.M309463200)
- Kemp, P. J. et al. 2003. Acute oxygen sensing in cellular models: relevance to the physiology of pulmonary neuroepithelial and carotid bodies. Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology 270A(1), pp. 41-50. (10.1002/ar.a.10008)
- Kemp, P. J., Peers, C. and Lewis, A. 2003. Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels. Regulation by acute hypoxia. Advances in Experimental Medicine and Biology 536, pp. 209-215.
- Miller, P., Kemp, P. J., Lewis, A., Chapman, C. G., Meadows, H. J. and Peers, C. 2003. Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K+ channels in central neuroprotection. The Journal of Physiology 548(1), pp. 31-37. (10.1113/jphysiol.2003.040048)
- Lewis, A., Peers, C., Ashford, M. L. J. and Kemp, P. J. 2002. Hypoxia inhibits human recombinant large conductance, Ca2+-activated K+ (maxi-K) channels by a mechanism which is membrane delimited and Ca2+ sensitive. The Journal of Physiology 540(3), pp. 771-780. (10.1113/jphysiol.2001.013888)
- Colebrooke, R. L., Smith, I. F., Kemp, P. J. and Peers, C. 2002. Chronic hypoxia remodels voltage-gated Ca2+ entry in a human airway chemoreceptor cell line. Neuroscience Letters 318(2), pp. 69-72. (10.1016/S0304-3940(01)02479-X)
- Plant, L. D., Kemp, P. J., Peers, C., Henderson, Z. and Pearson, H. A. 2002. Hypoxic depolarization of cerebellar granule neurons by specific inhibition of TASK-1. Stroke 33(9), pp. 2324-2328. (10.1161/01.STR.0000027440.68031.B0)
- Searle, G. J., Hartness, M. E., Hoareau, R., Peers, C. and Kemp, P. J. 2002. Lack of contribution of mitochondrial electron transport to acute O2 sensing in model airway chemoreceptors. Biochemical and Biophysical Research Communications 291(2), pp. 332-337. (10.1006/bbrc.2002.6428)
- Kemp, P. J., Lewis, A., Hartness, M. E., Searle, G. J., Miller, P., O'Kelly, I. and Peers, C. 2002. Airway chemotransduction: from oxygen sensor to cellular effector. American Journal of Respiratory and Critical Care Medicine 166, pp. S17-S24. (10.1164/rccm.2206009)
- Hartness, M. E., Lewis, A., Searle, G. J., O'Kelly, I., Peers, C. and Kemp, P. J. 2001. Combined antisense and pharmacological approaches implicate hTASK as an airway O2-sensing K+ channel. Journal of Biological Chemistry, pp. 26499-26508. (10.1074/jbc.M010357200)
- Baines, D. L., MacGregor, G. G. and Kemp, P. J. 2001. Fatty acid modulation and sequence identity of fetal guinea pig alveolar type II cell amiloride-sensitive Na+ channel. Biochemical and Biophysical Research Communications 288(3), pp. 727-735. (10.1006/bbrc.2001.5828)
- Kemp, P. J., Kim, K., Borok, Z. and Crandall, E. D. 2001. Re-evaluating the Na+ conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels. The Journal of Physiology 536(3), pp. 693-701. (10.1111/j.1469-7793.2001.t01-1-00693.x)
- O'Kelly, I., Peers, C. and Kemp, P. J. 2001. NADPH oxidase does not account fully for O2-Sensing in model airway chemoreceptor cells. Biochemical and Biophysical Research Communications 283(5), pp. 1131-1134. (10.1006/bbrc.2001.4919)
- Lewis, A., Hartness, M. E., Chapman, C. G., Fearon, I. M., Meadows, H. J., Peers, C. and Kemp, P. J. 2001. Recombinant hTASK1 Is an O2-sensitive K+ channel. Biochemical and Biophysical Research Communications 285(5), pp. 1290-1294. (10.1006/bbrc.2001.5310)
- Peers, C. and Kemp, P. J. 2001. Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors. Respiratory Research 2, pp. 145-149. (10.1186/rr51)
- O'Kelly, I., Lewis, A. and Kemp, P. J. 2000. O2 Sensing by Airway Chemoreceptor-derived cells protein kinase C activation reveals functional evidence for involvement of NADPH oxidase. Journal of Biological Chemistry 275(11), pp. 7684-7692. (10.1074/jbc.275.11.7684)
Book sections
- Kemp, P. J. and Peers, C. 2009. Enzyme-linked acute oxygen sensing in airway and arterial chemoreceptors. In: Gonzalez, C., Nurse, C. A. and Peers, C. eds. Arterial Chemoreceptors. Advances in Experimental Medicine and Biology Vol. 648. Netherlands: Springer Netherlands, pp. 39-48., (10.1007/978-90-481-2259-2_4)
- Kemp, P. J., Peers, C., Riccardi, D., Iles, D. E., Mason, H. S., Wootton, P. and Williams, S. E. 2006. In search of the acute oxygen sensor: Functional proteomics and acute regulation of large-conductance, calcium-activated potassium channels by hemeoxygenase-2. In: Hayashida, Y., Gonzalez, C. and Kondo, H. eds. The Arterial Chemoreceptors., Vol. 580. Advances in Experimental Medicine and Biology Springer, pp. 137-146., (10.1007/0-387-31311-7_21)
- Peers, C., Kemp, P. J., Boyle, J. P., Porter, K. E., Pearson, H. A., Smith, I. F. and Kemp, P. J. 2006. Hypoxic regulation of Ca2+ signalling in astrocytes and endothelial cells. In: Chadwick, D. and Goode, J. eds. Signalling Pathways in Acute Oxygen Sensing: Novartis Foundation Symposium 272. Wiley-Blackwell, pp. 119-127., (10.1002/9780470035009.ch10)
- Kemp, P. J., Williams, S. E., Mason, H. S., Wootton, P., Iles, D. E., Riccardi, D. and Peers, C. 2006. Functional proteomics of BK potassium channels: Defining the acute oxygen sensor. In: Chadwick, D. J. and Goode, J. eds. Signalling Pathways in Acute Oxygen Sensing: Novartis Foundation Symposium 272. Novartis Foundation Symposia Wiley-Blackwell, pp. 141-151., (10.1002/9780470035009.ch12)
- Peers, C., Aley, P. K., Boyle, J. P., Porter, K. E., Pearson, H. A., Smith, I. F. and Kemp, P. J. 2006. Hypoxic regulation of Ca2+ signalling in astrocytes and endothelial cells. In: Hayashida, Y., Gonzalez, C. and Konda, H. eds. The Arterial Chemoreceptors., Vol. 580. Advances in Experimental Medicine and Biology Kluwer, pp. 185-190., (10.1007/0-387-31311-7_28)
- Kemp, P. J., Peers, C., Miller, P. and Lewis, A. 2002. Oxygen sensing by human recombinant tandem-P domain potassium channels. In: Pequinot, J. et al. eds. Chemoreception: From Cellular Signaling to Functional Plasticity. Advances in Experimental Medicine and Biology Springer, pp. 201-208., (10.1007/978-1-4419-9280-2_26)
- Kemp, P. J., Hartness, M. E. and Peers, C. 2002. Oxygen sensing by human recombinant large conductance, calcium-activated potassium channels:regulation by chronic hypoxia. In: Pequignot, J. et al. eds. Chemoreception: From Cellular Signaling to Functional Plasticity. Advances in Experimental Medicine and Biology Springer, pp. 573-581.
- Kemp, P. J., Peers, C., Miller, P. and Lewis, A. 2000. O2-sensing by model airway chemoreceptors: hypoxic inhibition of K+ channels in H146 cells. In: Pequignot, J. et al. eds. Chemoreception: From Cellular Signaling to Functional Plasticity. Advances in Experimental Medicine and Biology Springer, pp. 611-622., (10.1007/978-1-4419-9280-2_26)
Conferences
- Brazier, S. P., Telezhkin, V., Mears, R., Müller, T., Riccardi, D. and Kemp, P. J. 2009. Cysteine residues in the C-terminal tail of the human BKCaα subunit are important for channel sensitivity to carbon monoxide. Presented at: International Society of Arterial Chemoreception. 17th Meeting, Valladolid, Spain, 1-5 July 2008Arterial Chemoreceptors. Advances in Experimental Medicine and Biology Vol. 648. Netherlands: Springer Netherlands pp. 49-56., (10.1007/978-90-481-2259-2_5)
- Cayzac, S., Rocher, A., Obeso, A., Gonzalez, C., Kemp, P. J. and Riccardi, D. 2009. Effects of the polyamine spermine on arterial chemoreception. Presented at: International Society of Arterial Chemoreception. 17th Meeting, Valladolid, Spain, 1-5 July 2008 Presented at Gonzalez, C., Nurse, C. A. and Peers, C. eds.Arterial chemoreceptors. Advances in Experimental Medicine and Biology Vol. 648. Netherlands: Springer Netherlands pp. 97-104., (10.1007/978-90-481-2259-2_11)