Overview
Schizophrenia is a psychiatric disorder which affects around 1% of the population. There is no one single cause of schizophrenia, but genetics is known to play a substantial role. Mutations thought to be linked to schizophrenia are often seen in individuals without a schizophrenia diagnosis, and my research investigates the impact these mutations have on an individual’s characteristics using large-scale next-generation sequencing data. I am particularly interested in investigating the association of schizophrenia-associated rare, damaging mutations and neuropsychiatric phenotypes.
Undergraduate Education
BSc (Hons) Natural Sciences Specialising in Neuroscience, University of York
Postgraduate Education
PhD Integrative Neuroscience (current), Cardiff University
Awards/External Committees
Wellcome Trust 4-year PhD Integrative Neuroscience
Laidlaw Undergraduate Research and Leadership Scholarship
Publication
2024
- Kappel, D. et al. 2024. Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia. European Neuropsychopharmacology 80, pp. 47-54. (10.1016/j.euroneuro.2023.12.007)
2023
- Fenner, E. 2023. Discovery and impact of schizophrenia rare genetic variation using next generation sequencing. PhD Thesis, Cardiff University.
2022
- Wadon, M., Fenner, E., Kendall, K., Bailey, G., Sandor, C., Rees, E. and Peall, K. J. 2022. Clinical and genotypic analysis in determining dystonia non-motor phenotypic heterogeneity: a UK Biobank study. Journal of Neurology 269, pp. 6436-6451. (10.1007/s00415-022-11307-4)
Erthyglau
- Kappel, D. et al. 2024. Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia. European Neuropsychopharmacology 80, pp. 47-54. (10.1016/j.euroneuro.2023.12.007)
- Wadon, M., Fenner, E., Kendall, K., Bailey, G., Sandor, C., Rees, E. and Peall, K. J. 2022. Clinical and genotypic analysis in determining dystonia non-motor phenotypic heterogeneity: a UK Biobank study. Journal of Neurology 269, pp. 6436-6451. (10.1007/s00415-022-11307-4)
Gosodiad
- Fenner, E. 2023. Discovery and impact of schizophrenia rare genetic variation using next generation sequencing. PhD Thesis, Cardiff University.