![Marcella Bassetto](https://profiles-cardiff.imgix.net/attachments/2895?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Marcella Bassetto
(she/her)
- Available for postgraduate supervision
Teams and roles for Marcella Bassetto
Senior Lecturer
Overview
I am a medicinal organic chemist working in the drug discovery research field. I hold an MSc degree in Pharmaceutical Chemistry from Padova University, and a PhD in Medicinal Chemistry from Cardiff University, which I completed in 2013, with a thesis on the computer-aided identification and synthesis of novel antiviral agents to inhibit HCV replication. With my post-graduate and early post-doctoral work, I have applied computational methods to design, and then synthesise, novel chemical entities with pharmaceutical activities as antiviral and anticancer agents.
As a research associate, I worked in the group of late Professor Chris McGuigan, the inventor of the phosphoramidate pro-drug technology for antiviral and anticancer nucleosides. After briefly joining a pharmaceutical company in Rome, where I contributed to the development of novel therapeutic agents for a range of human conditions, I returned to Cardiff University as a research associate, and in 2016 was awarded a Sêr Cymru II individual research fellowship, to optimise new small organic molecules as potential antiviral agents for Chikungunya and Zika viruses.
In September 2019, I was awarded a Lectureship in Chemistry at Swansea University Department of Chemistry, becoming Senior Lecturer in February 2022. Starting in January 2023, I have been appointed Senior Lecturer at Cardiff School of Pharmacy and Pharmaceutical Sciences. My current drug discovery research focusses on the computer-aided design and synthesis of new biologically active small molecules to treat a range of human conditions, with a major focus on viral diseases (norovirus, CHIKV, ZIKV, enteroviruses, Ebola virus, coronaviruses, arenaviruses) and inherited blinding conditions.
I have been a STEM Ambassador since 2016.
Publication
2026
- Clarke, R. et al. 2026. Computer-aided drug discovery: historical foundations, practical AI tools, and emerging ethical considerations. Frontiers in Pharmacology 17 1866562. (10.3389/fphar.2026.1866562)
- Wasson, S. R. et al., 2026. Computer-aided discovery of small-molecule inhibitors of pathogenic new world arenavirus entry and replication. ACS Infectious Diseases 12 (6), pp.2046-2059. (10.1021/acsinfecdis.6c00138)
2025
- Palazzo, G. , Ferla, S. and Bassetto, M. 2025. Computer-aided approaches for human norovirus drug discovery: a comprehensive review. Expert Opinion on Drug Discovery 20 (12), pp.1589-1606. (10.1080/17460441.2025.2601118)
- Meades, J. L. et al., 2025. Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABA A receptors. British Journal of Pharmacology 182 (21), pp.5286-5302. (10.1111/bph.70121)
- Queirós-Reis, L. et al., 2025. In silico discovery of a novel antiviral scaffold for SARS-CoV-2 targeting the spike glycoprotein through the fatty acid binding pocket. ACS Omega 10 (23), pp.24117-24132. (10.1021/acsomega.4c10519)
- Felippe, I. S. A. et al., 2025. Vitamin B6 (pyridoxal 5’ phosphate) antagonizes carotid body P2X3 receptors in hypertension. Cardiovascular Research 122 (2), pp.285-296. cvaf195. (10.1093/cvr/cvaf195)
2024
- Ng, M. Y. et al., 2024. Structural investigations on the mitochondrial uncouplers niclosamide and FCCP. FEBS Open Bio 14 (7), pp.1057-1071. (10.1002/2211-5463.13817)
- Ng, M. Y. et al., 2024. Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation. Scientific Reports 14 (1) 4932. (10.1038/s41598-024-54466-2)
2023
- Queirós-Reis, L. et al., 2023. Exploring the fatty acid binding pocket in the SARS-CoV-2 spike protein - confirmed and potential ligands. Journal of Chemical Information and Modeling 63 (23), pp.7282–7298. (10.1021/acs.jcim.3c00803)
- Gushchina, V. et al., 2023. The calcium-sensing receptor modulates the prostaglandin E 2 pathway in intestinal inflammation. Frontiers in Pharmacology 14 1151144. (10.3389/fphar.2023.1151144)
- Salerno, M. et al., 2023. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. European Journal of Medicinal Chemistry 246 114942. (10.1016/j.ejmech.2022.114942)
2022
- Giancotti, G. et al., 2022. Structural investigations on novel non-nucleoside inhibitors of human norovirus polymerase. Viruses 15 (1) 74. (10.3390/v15010074)
- Picarazzi, F. et al., 2022. Identification of small molecular chaperones binding p23h mutant opsin through an in silico structure-based approach. Journal of Chemical Information and Modeling 62 (22), pp.5794-5805. (10.1021/acs.jcim.2c01040)
- Menendez-Gonzalez, J. B. et al., 2022. Ligand-based discovery of a novel GATA2 inhibitor targeting acute myeloid leukemia cells. Frontiers In Drug Discovery 2 1013229. (10.3389/fddsv.2022.1013229)
- Gill, M. R. et al., 2022. A ruthenium(II) polypyridyl complex disrupts actin cytoskeleton assembly and blocks cytokinesis. Angewandte chemie-international edition 61 (27) e202117449. (10.1002/anie.202117449)
- Hucke, F. I. L. et al., 2022. CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251. Virus Genes 58 , pp.188-202. (10.1007/s11262-022-01892-x)
2021
- Padalino, G. et al. 2021. Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. European Journal of Medicinal Chemistry 226 113823. (10.1016/j.ejmech.2021.113823)
- Pasqualetto, G. et al. 2021. Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin. European Journal of Medicinal Chemistry 226 113841. (10.1016/j.ejmech.2021.113841)
- Bassetto, M. and Brancale, A. 2021. The search for antivirals to treat alphavirus infections. In: Annual Reports in Medicinal Chemistry. Vol. 57, Coronaviruses and other Novel Antiviral Targets Elsevier. , pp.133-151. (10.1016/bs.armc.2021.09.002)
- Queirós-Reis, L. et al., 2021. SARS-CoV-2 virus-host interaction: currently available structures and implications of variant emergence on infectivity and immune response. International Journal of Molecular Sciences 22 (19) 10836. (10.3390/ijms221910836)
- Schepelmann, M. et al., 2021. Stereo-specific modulation of the extracellular calcium-sensing receptor in colon cancer cells. International Journal of Molecular Sciences 22 (18) 10124. (10.3390/ijms221810124)
- Ferla, S. et al. 2021. Structure-activity relationship studies on novel antiviral agents for norovirus infections. Microorganisms 9 (9) 1795. (10.3390/microorganisms9091795)
- Flude, B. M. et al., 2021. Targeting the complement serine protease MASP-2 as a therapeutic strategy for coronavirus infections. Viruses 13 (2) 312. (10.3390/v13020312)
2020
- Fernández-García, Y. et al., 2020. Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales. Antiviral Research 183 104947. (10.1016/j.antiviral.2020.104947)
- ter Horst, S. et al., 2020. Enhanced efficacy of endonuclease inhibitor baloxavir acid against orthobunyaviruses when used in combination with ribavirin. Journal of Antimicrobial Chemotherapy 75 (11), pp.3189-3193. (10.1093/jac/dkaa337)
- Thames, J. E. et al., 2020. Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro. Bioorganic and Medicinal Chemistry 28 (22) 115713. (10.1016/j.bmc.2020.115713)
- Bauer, L. et al., 2020. Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C. PLOS Biology 18 (11) e3000904. (10.1371/journal.pbio.3000904)
- Pasqualetto, G. et al. 2020. Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins. Molecules 25 (21) 4904. (10.3390/molecules25214904)
- Bassetto, M. et al. 2020. Novel nucleoside analogues as affective antiviral agents for Zika virus infections. Molecules 25 (20) 4813. (10.3390/molecules25204813)
- Bugert, J. J. et al., 2020. Antivirals in medical biodefense. Virus Genes 56 (2), pp.150-167. (10.1007/s11262-020-01737-5)
- Ferla, S. et al. 2020. Rational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein. Bioorganic and Medicinal Chemistry 28 (8) 115401. (10.1016/j.bmc.2020.115401)
2019
- Elajnaf, T. et al., 2019. Nutritional and pharmacological targeting of the calcium-sensing receptor influences chemically induced colitis in mice. Nutrients 11 (12) 3072. (10.3390/nu11123072)
- Giancotti, G. et al. 2019. A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase. Scientific Reports 9 (1) 18413. (10.1038/s41598-019-54903-7)
- Pertusati, F. et al. 2019. A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer. European Journal of Medicinal Chemistry 180 , pp.1-14. (10.1016/j.ejmech.2019.07.001)
- Pasqualetto, G. et al. 2019. Novel small-molecule chaperones to overcome opsin misfolding, mistrafficking and aggregation in retinal blinding diseases [Abstract]. Investigative Ophthalmology & Visual Science 60 (9)
- Pileggi, E. et al. 2019. Development of novel treatments against inherited blinding diseases Retinitis pigmentosa and Leber's congenital amaurosis [Abstract]. Abstracts of Papers of the American Chemical Society 257 318.
- Bassetto, M. et al. 2019. Targeting the viral polymerase of diarrhea-causing viruses as a strategy to develop a single broad-spectrum antiviral therapy. Viruses 11 (2) 173. (10.3390/v11020173)
- Bassetto, M. and Slusarczyk, M. 2019. Therapeutic use of fluorinated nucleosides – progress in patents. Pharmaceutical Patent Analyst 7 (6), pp.277. (10.4155/ppa-2018-0028)
2018
- Giancotti, G. et al. 2018. Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus. European Journal of Medicinal Chemistry 149 , pp.56-68. (10.1016/j.ejmech.2018.02.054)
- Ferla, S. et al. 2018. In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase. Scientific Reports 8 (4129) 4129. (10.1038/s41598-018-22303-y)
- Tardugno, R. et al., 2018. Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents. Bioorganic and Medicinal Chemistry 26 (4), pp.869-874. (10.1016/j.bmc.2018.01.002)
2017
- Bassetto, M. et al. 2017. Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents. MedChemComm 8 (7), pp.1414-1420. (10.1039/C7MD00164A)
- Brancale, A. et al. 2017. Therapeutically targeting guanylate cyclase-C: computational modeling of plecanatide, a uroguanylin analog. Pharmacology Research & Perspectives 5 (2) e00295. (10.1002/prp2.295)
- Bassetto, M. et al. 2017. Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV. Bioorganic & Medicinal Chemistry Letters 27 (4), pp.936-940. (10.1016/j.bmcl.2016.12.087)
- Bassetto, M. et al. 2017. In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase. European Journal of Medicinal Chemistry 125 , pp.1115-1131. (10.1016/j.ejmech.2016.10.043)
2016
- Bassetto, M. et al. 2016. Structural biology in antiviral drug discovery. Current Opinion in Pharmacology 30 , pp.116-130. (10.1016/j.coph.2016.08.014)
- Bassetto, M. et al. 2016. Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry 118 , pp.230-243. (10.1016/j.ejmech.2016.04.052)
- Ferla, S. et al. 2016. Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic and Medicinal Chemistry Letters 26 (15), pp.3636-3640. (10.1016/j.bmcl.2016.06.001)
- Bassetto, M. et al. 2016. Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication. European Journal of Medicinal Chemistry (10.1016/j.ejmech.2016.07.035)
2015
- Cancellieri, M. et al. 2015. In silico structure-based design and synthesis of novel anti-RSV compounds. Antiviral Research 122 , pp.46-50. (10.1016/j.antiviral.2015.08.003)
2014
- Wang, X. et al., 2014. Potent, long-acting cyclopentane-1,3-Dione Thromboxane (A2)-receptor antagonists. ACS Medicinal Chemistry Letters 5 (9), pp.1015-1020. (10.1021/ml5002085)
2013
- Bassetto, M. 2013. Computer-aided design, synthesis and evaluation of potential anti-HCV agents. PhD Thesis , Cardiff University.
- Bassetto, M. et al. 2013. Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus. Antiviral Research 98 (1), pp.12-18. (10.1016/j.antiviral.2013.01.002)
- Romagnoli, R. et al., 2013. Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents. Journal of Medicinal Chemistry 56 (6), pp.2606-2618. (10.1021/jm400043d)
- Romagnoli, R. et al., 2013. Concise synthesis and biological evaluation of 2-aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents. Journal of Medicinal Chemistry 56 (22), pp.9296-9309. (10.1021/jm4013938)
2012
- Romagnoli, R. et al., 2012. Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents. Bioorganic & Medicinal Chemistry 20 (24), pp.7083-7094. (10.1016/j.bmc.2012.10.001)
Articles
- Clarke, R. et al. 2026. Computer-aided drug discovery: historical foundations, practical AI tools, and emerging ethical considerations. Frontiers in Pharmacology 17 1866562. (10.3389/fphar.2026.1866562)
- Wasson, S. R. et al., 2026. Computer-aided discovery of small-molecule inhibitors of pathogenic new world arenavirus entry and replication. ACS Infectious Diseases 12 (6), pp.2046-2059. (10.1021/acsinfecdis.6c00138)
- Palazzo, G. , Ferla, S. and Bassetto, M. 2025. Computer-aided approaches for human norovirus drug discovery: a comprehensive review. Expert Opinion on Drug Discovery 20 (12), pp.1589-1606. (10.1080/17460441.2025.2601118)
- Meades, J. L. et al., 2025. Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABA A receptors. British Journal of Pharmacology 182 (21), pp.5286-5302. (10.1111/bph.70121)
- Queirós-Reis, L. et al., 2025. In silico discovery of a novel antiviral scaffold for SARS-CoV-2 targeting the spike glycoprotein through the fatty acid binding pocket. ACS Omega 10 (23), pp.24117-24132. (10.1021/acsomega.4c10519)
- Felippe, I. S. A. et al., 2025. Vitamin B6 (pyridoxal 5’ phosphate) antagonizes carotid body P2X3 receptors in hypertension. Cardiovascular Research 122 (2), pp.285-296. cvaf195. (10.1093/cvr/cvaf195)
- Ng, M. Y. et al., 2024. Structural investigations on the mitochondrial uncouplers niclosamide and FCCP. FEBS Open Bio 14 (7), pp.1057-1071. (10.1002/2211-5463.13817)
- Ng, M. Y. et al., 2024. Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation. Scientific Reports 14 (1) 4932. (10.1038/s41598-024-54466-2)
- Queirós-Reis, L. et al., 2023. Exploring the fatty acid binding pocket in the SARS-CoV-2 spike protein - confirmed and potential ligands. Journal of Chemical Information and Modeling 63 (23), pp.7282–7298. (10.1021/acs.jcim.3c00803)
- Gushchina, V. et al., 2023. The calcium-sensing receptor modulates the prostaglandin E 2 pathway in intestinal inflammation. Frontiers in Pharmacology 14 1151144. (10.3389/fphar.2023.1151144)
- Salerno, M. et al., 2023. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. European Journal of Medicinal Chemistry 246 114942. (10.1016/j.ejmech.2022.114942)
- Giancotti, G. et al., 2022. Structural investigations on novel non-nucleoside inhibitors of human norovirus polymerase. Viruses 15 (1) 74. (10.3390/v15010074)
- Picarazzi, F. et al., 2022. Identification of small molecular chaperones binding p23h mutant opsin through an in silico structure-based approach. Journal of Chemical Information and Modeling 62 (22), pp.5794-5805. (10.1021/acs.jcim.2c01040)
- Menendez-Gonzalez, J. B. et al., 2022. Ligand-based discovery of a novel GATA2 inhibitor targeting acute myeloid leukemia cells. Frontiers In Drug Discovery 2 1013229. (10.3389/fddsv.2022.1013229)
- Gill, M. R. et al., 2022. A ruthenium(II) polypyridyl complex disrupts actin cytoskeleton assembly and blocks cytokinesis. Angewandte chemie-international edition 61 (27) e202117449. (10.1002/anie.202117449)
- Hucke, F. I. L. et al., 2022. CHIKV strains Brazil (wt) and Ross (lab-adapted) differ with regard to cell host range and antiviral sensitivity and show CPE in human glioblastoma cell lines U138 and U251. Virus Genes 58 , pp.188-202. (10.1007/s11262-022-01892-x)
- Padalino, G. et al. 2021. Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. European Journal of Medicinal Chemistry 226 113823. (10.1016/j.ejmech.2021.113823)
- Pasqualetto, G. et al. 2021. Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin. European Journal of Medicinal Chemistry 226 113841. (10.1016/j.ejmech.2021.113841)
- Queirós-Reis, L. et al., 2021. SARS-CoV-2 virus-host interaction: currently available structures and implications of variant emergence on infectivity and immune response. International Journal of Molecular Sciences 22 (19) 10836. (10.3390/ijms221910836)
- Schepelmann, M. et al., 2021. Stereo-specific modulation of the extracellular calcium-sensing receptor in colon cancer cells. International Journal of Molecular Sciences 22 (18) 10124. (10.3390/ijms221810124)
- Ferla, S. et al. 2021. Structure-activity relationship studies on novel antiviral agents for norovirus infections. Microorganisms 9 (9) 1795. (10.3390/microorganisms9091795)
- Flude, B. M. et al., 2021. Targeting the complement serine protease MASP-2 as a therapeutic strategy for coronavirus infections. Viruses 13 (2) 312. (10.3390/v13020312)
- Fernández-García, Y. et al., 2020. Diketo acids inhibit the cap-snatching endonuclease of several Bunyavirales. Antiviral Research 183 104947. (10.1016/j.antiviral.2020.104947)
- ter Horst, S. et al., 2020. Enhanced efficacy of endonuclease inhibitor baloxavir acid against orthobunyaviruses when used in combination with ribavirin. Journal of Antimicrobial Chemotherapy 75 (11), pp.3189-3193. (10.1093/jac/dkaa337)
- Thames, J. E. et al., 2020. Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro. Bioorganic and Medicinal Chemistry 28 (22) 115713. (10.1016/j.bmc.2020.115713)
- Bauer, L. et al., 2020. Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C. PLOS Biology 18 (11) e3000904. (10.1371/journal.pbio.3000904)
- Pasqualetto, G. et al. 2020. Computational studies towards the identification of novel rhodopsin-binding compounds as chemical chaperones for misfolded opsins. Molecules 25 (21) 4904. (10.3390/molecules25214904)
- Bassetto, M. et al. 2020. Novel nucleoside analogues as affective antiviral agents for Zika virus infections. Molecules 25 (20) 4813. (10.3390/molecules25204813)
- Bugert, J. J. et al., 2020. Antivirals in medical biodefense. Virus Genes 56 (2), pp.150-167. (10.1007/s11262-020-01737-5)
- Ferla, S. et al. 2020. Rational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein. Bioorganic and Medicinal Chemistry 28 (8) 115401. (10.1016/j.bmc.2020.115401)
- Elajnaf, T. et al., 2019. Nutritional and pharmacological targeting of the calcium-sensing receptor influences chemically induced colitis in mice. Nutrients 11 (12) 3072. (10.3390/nu11123072)
- Giancotti, G. et al. 2019. A new antiviral scaffold for human norovirus identified with computer-aided approaches on the viral polymerase. Scientific Reports 9 (1) 18413. (10.1038/s41598-019-54903-7)
- Pertusati, F. et al. 2019. A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer. European Journal of Medicinal Chemistry 180 , pp.1-14. (10.1016/j.ejmech.2019.07.001)
- Pasqualetto, G. et al. 2019. Novel small-molecule chaperones to overcome opsin misfolding, mistrafficking and aggregation in retinal blinding diseases [Abstract]. Investigative Ophthalmology & Visual Science 60 (9)
- Pileggi, E. et al. 2019. Development of novel treatments against inherited blinding diseases Retinitis pigmentosa and Leber's congenital amaurosis [Abstract]. Abstracts of Papers of the American Chemical Society 257 318.
- Bassetto, M. et al. 2019. Targeting the viral polymerase of diarrhea-causing viruses as a strategy to develop a single broad-spectrum antiviral therapy. Viruses 11 (2) 173. (10.3390/v11020173)
- Bassetto, M. and Slusarczyk, M. 2019. Therapeutic use of fluorinated nucleosides – progress in patents. Pharmaceutical Patent Analyst 7 (6), pp.277. (10.4155/ppa-2018-0028)
- Giancotti, G. et al. 2018. Rational modifications on a benzylidene-acrylohydrazide antiviral scaffold, synthesis and evaluation of bioactivity against Chikungunya virus. European Journal of Medicinal Chemistry 149 , pp.56-68. (10.1016/j.ejmech.2018.02.054)
- Ferla, S. et al. 2018. In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase. Scientific Reports 8 (4129) 4129. (10.1038/s41598-018-22303-y)
- Tardugno, R. et al., 2018. Design, synthesis and evaluation against Chikungunya virus of novel small-molecule antiviral agents. Bioorganic and Medicinal Chemistry 26 (4), pp.869-874. (10.1016/j.bmc.2018.01.002)
- Bassetto, M. et al. 2017. Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents. MedChemComm 8 (7), pp.1414-1420. (10.1039/C7MD00164A)
- Brancale, A. et al. 2017. Therapeutically targeting guanylate cyclase-C: computational modeling of plecanatide, a uroguanylin analog. Pharmacology Research & Perspectives 5 (2) e00295. (10.1002/prp2.295)
- Bassetto, M. et al. 2017. Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV. Bioorganic & Medicinal Chemistry Letters 27 (4), pp.936-940. (10.1016/j.bmcl.2016.12.087)
- Bassetto, M. et al. 2017. In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase. European Journal of Medicinal Chemistry 125 , pp.1115-1131. (10.1016/j.ejmech.2016.10.043)
- Bassetto, M. et al. 2016. Structural biology in antiviral drug discovery. Current Opinion in Pharmacology 30 , pp.116-130. (10.1016/j.coph.2016.08.014)
- Bassetto, M. et al. 2016. Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer. European Journal of Medicinal Chemistry 118 , pp.230-243. (10.1016/j.ejmech.2016.04.052)
- Ferla, S. et al. 2016. Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety. Bioorganic and Medicinal Chemistry Letters 26 (15), pp.3636-3640. (10.1016/j.bmcl.2016.06.001)
- Bassetto, M. et al. 2016. Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication. European Journal of Medicinal Chemistry (10.1016/j.ejmech.2016.07.035)
- Cancellieri, M. et al. 2015. In silico structure-based design and synthesis of novel anti-RSV compounds. Antiviral Research 122 , pp.46-50. (10.1016/j.antiviral.2015.08.003)
- Wang, X. et al., 2014. Potent, long-acting cyclopentane-1,3-Dione Thromboxane (A2)-receptor antagonists. ACS Medicinal Chemistry Letters 5 (9), pp.1015-1020. (10.1021/ml5002085)
- Bassetto, M. et al. 2013. Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus. Antiviral Research 98 (1), pp.12-18. (10.1016/j.antiviral.2013.01.002)
- Romagnoli, R. et al., 2013. Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents. Journal of Medicinal Chemistry 56 (6), pp.2606-2618. (10.1021/jm400043d)
- Romagnoli, R. et al., 2013. Concise synthesis and biological evaluation of 2-aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents. Journal of Medicinal Chemistry 56 (22), pp.9296-9309. (10.1021/jm4013938)
- Romagnoli, R. et al., 2012. Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents. Bioorganic & Medicinal Chemistry 20 (24), pp.7083-7094. (10.1016/j.bmc.2012.10.001)
Book sections
- Bassetto, M. and Brancale, A. 2021. The search for antivirals to treat alphavirus infections. In: Annual Reports in Medicinal Chemistry. Vol. 57, Coronaviruses and other Novel Antiviral Targets Elsevier. , pp.133-151. (10.1016/bs.armc.2021.09.002)
Thesis
- Bassetto, M. 2013. Computer-aided design, synthesis and evaluation of potential anti-HCV agents. PhD Thesis , Cardiff University.
Research
Areas of expertise:
- Molecular modelling
- Computer-aided drug design
- Medicinal Chemistry
- Synthetic organic chemistry
- Antiviral research
