![Xavier Caseras](https://profiles-cardiff.imgix.net/attachments/650?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Xavier Caseras
Reader, Division of Psychological Medicine and Clinical Neurosciences
- CaserasX@cardiff.ac.uk
- +44 29206 88437
- Hadyn Ellis Building, Room 2.21, Maindy Road, Cardiff, CF24 4HQ
- Available for postgraduate supervision
Overview
My main research interest is in vulnerability and resilience to mental disorders. I am particularly interested in investigating the factors that might predispose some people to develop affective and anxiety disorders as well as the factors that might protect at risk populations from developing these disorders. Among those predisposing/protecting factors my research mainly deals with emotion processing and regulation, brain functional and structural neuroanatomy and genetic makeup.
Publication
2023
- Steventon, J. J. et al. 2023. Menopause age, reproductive span and hormone therapy duration predict the volume of medial temporal lobe brain structures in postmenopausal women. Psychoneuroendocrinology 158, article number: 106393. (10.1016/j.psyneuen.2023.106393)
- Caseras, X., Legge, S., Bracher-Smith, M., Anney, R., Owen, M., Escott-Price, V. and Kirov, G. 2023. Copy Number Variants increasing risk for schizophrenia: shared and distinct effects on brain morphometry and cognitive performance. Biological Psychiatry: Global Open Science 3(4), pp. 902-911. (10.1016/j.bpsgos.2022.10.006)
- Harrison, J. R. et al. 2023. Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults. Brain Communications 5(5), article number: fcad229. (10.1093/braincomms/fcad229)
2022
- Mirza-Davies, A. et al. 2022. The impact of genetic risk for Alzheimer’s disease on the structural brain networks of young adults. Frontiers in Neuroscience 16, article number: 987677. (10.3389/fnins.2022.987677)
- Chambers, T. et al. 2022. Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank. Molecular Psychiatry 27, pp. 2282-2290. (10.1038/s41380-022-01443-8)
- Ching, C. R. K. et al. 2022. What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA bipolar disorder working group. Human Brain Mapping 43(1), pp. 56-82. (10.1002/hbm.25098)
- Zwarte, S. M. C. et al. 2022. Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder. Human Brain Mapping 43(1), pp. 414-430. (10.1002/hbm.25206)
- Frangou, S. et al. 2022. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years. Human Brain Mapping 43(1), pp. 431-451. (10.1002/hbm.25364)
- Dima, D. et al. 2022. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping 43(1), pp. 452-469. (10.1002/hbm.25320)
- Wierenga, L. M. et al. 2022. Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping 43(1), pp. 470-499. (10.1002/hbm.25204)
2021
- Silva, A. I. et al. 2021. Analysis of diffusion tensor imaging data from the UK Biobank confirms dosage effect of 15q11.2 copy number variation on white matter and shows association with cognition. Biological Psychiatry 90(5), pp. 307-316. (10.1016/j.biopsych.2021.02.969)
- Chambers, T. et al. 2021. Effects of thyroid status on regional brain volumes: a diagnostic and genetic imaging study in UK Biobank. Journal of Clinical Endocrinology and Metabolism 106(3), pp. 688-696. (10.1210/clinem/dgaa903)
- Caseras, X. et al. 2021. Effects of genomic copy number variants penetrant for schizophrenia on cortical thickness and surface area in healthy individuals: analysis of the UK Biobank. British Journal of Psychiatry 218(2), pp. 104-111. (10.1192/bjp.2020.139)
2020
- Nunes, A. et al. 2020. Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Molecular Psychiatry 25, pp. 2130-2143. (10.1038/s41380-018-0228-9)
- Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57(10), pp. 692-698. (10.1136/jmedgenet-2019-106676)
- Grama, S. et al. 2020. Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort. Translational Psychiatry 10, article number: 309. (10.1038/s41398-020-00940-0)
- Gubb, S., Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29(17), pp. 2872-2881. (10.1093/hmg/ddaa174)
- Chandler, H. L., Hodgetts, C. J., Caseras, X., Murphy, K. and Lancaster, T. M. 2020. Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity. Neuropsychopharmacology 45, pp. 1171-1178. (10.1038/s41386-019-0595-1)
- Han, L. K. M. et al. 2020. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. Molecular Psychiatry 26, pp. 5124-5139. (10.1038/s41380-020-0754-0)
- Warland, A., Kendall, K. M., Rees, E., Kirov, G. and Caseras, X. 2020. Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank. Molecular Psychiatry 25(4), pp. 854-862. (10.1038/s41380-019-0355-y)
- Warne, N., Caseras, X. and Rice, F. 2020. The cross-sectional and longitudinal relationship between overgeneral autobiographical memory and adolescent depression in a UK population-based cohort. Journal of Affective Disorders 266, pp. 621-625. (10.1016/j.jad.2020.02.011)
- Grasby, K. L. et al. 2020. The genetic architecture of the human cerebral cortex. Science 367(6484), article number: eaay6690. (10.1126/science.aay6690)
2019
- Favre, P. et al. 2019. Widespread white matter microstructural abnormalities in bipolar disorder: Evidence from mega- and meta-analyses across 3,033 individuals. Neuropsychopharmacology 44, pp. 2285-2293. (10.1038/s41386-019-0485-6)
- Favre, P. et al. 2019. Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals. Neuropsychopharmacology 44, pp. 2285-2293. (10.1038/s41386-019-0485-6)
- de Zwarte, S. M. C. et al. 2019. The association between familial risk and brain abnormalities is disease-specific: an ENIGMA–Relatives study of schizophrenia and bipolar disorder. Biological Psychiatry 86(7), pp. 545-556. (10.1016/j.biopsych.2019.03.985)
2018
- Whittaker, J. R., Foley, S. F., Ackling, E., Murphy, K. and Caseras, X. 2018. The functional connectivity between the nucleus accumbens and the ventromedial prefrontal cortex as an endophenotype for bipolar disorder. Biological Psychiatry 84(11), pp. 803-809. (10.1016/j.biopsych.2018.07.023)
- Foley, S. F., Bracher-Smith, M., Tansey, K. E., Harrison, J., Parker, G. D. and Caseras, X. 2018. Fractional anisotropy of the uncinate fasciculus and cingulum in bipolar disorder type I, type II, their unaffected siblings and healthy controls. British Journal of Psychiatry 213(3), pp. 548-554. (10.1192/bjp.2018.101)
- Salavert, J. et al. 2018. Functional imaging changes in the medial prefrontal cortex in adult ADHD. Journal of Attention Disorders 22(7), pp. 679-693. (10.1177/1087054715611492)
2017
- Andreassen, O. A., Hibar, D. P., Westlye, L. T. and Caseras, X. 2017. Cortical abnormalities in bipolar disorder: An MRI analysis of 6,503 individuals from the ENIGMA-Bipolar Disorder Working Group. Molecular Psychiatry 23, pp. 932-942. (10.1038/mp.2017.73)
- Gutierrez, F. et al. 2017. Psychometric properties of the Spanish PID-5 in a clinical and a community sample. Assessment 24(3), pp. 326-336. (10.1177/1073191115606518)
- Foley, S. F. et al. 2017. Multimodal brain imaging reveals structural differences in Alzheimer's disease polygenic risk carriers: A study in healthy young adults. Biological Psychiatry 81(2), pp. 154-161. (10.1016/j.biopsych.2016.02.033)
2016
- Hibar, D. P. et al. 2016. Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry 21(12), pp. 1710-1716. (10.1038/mp.2015.227)
- Lancaster, T., Foley, S., Tansey, K. E., Linden, D. E. J. and Caseras, X. 2016. CACNA1C risk variant is associated with increased amygdala volume. European Archives of Psychiatry and Clinical Neuroscience 266(3), pp. 269-275. (10.1007/s00406-015-0609-x)
2015
- Caseras, X., Tansey, K. E., Foley, S. and Linden, D. 2015. Association between genetic risk scoring for schizophrenia and bipolar disorder with regional subcortical volumes. Translational Psychiatry 5, article number: e692. (10.1038/tp.2015.195)
- Caseras, X., Murphy, K., Lawrence, N. S., Fuentes-Claramonte, P., Watts, J., Jones, D. K. and Phillips, M. L. 2015. Emotion regulation deficits in euthymic bipolar I versus bipolar II disorder: a functional and diffusion-tensor imaging study. Bipolar Disorders 17(5), pp. 461-470. (10.1111/bdi.12292)
- Lipp, I., Murphy, K., Caseras, X. and Wise, R. G. 2015. Agreement and repeatability of vascular reactivity estimates based on a breath-hold task and a resting state scan. NeuroImage 113, pp. 387-396. (10.1016/j.neuroimage.2015.03.004)
- Lipp, I., Evans, C. J., Lewis, C., Murphy, K., Wise, R. G. and Caseras, X. 2015. The relationship between fearfulness, GABA, and fear-related BOLD responses in the insula. Plos One 10(3), article number: e0120101. (10.1371/journal.pone.0120101)
2014
- Olatunji, B. O. et al. 2014. Predicting response to cognitive behavioral therapy in contamination-based obsessive-compulsive disorder from functional magnetic resonance imaging. Psychological Medicine 44(10), pp. 2125-2137. (10.1017/S0033291713002766)
- Torrents-Rodas, D., Fullana, M. A., Bonillo, A., Andión, O., Molinuevo, B., Caseras, X. and Torrubia, R. 2014. Testing the temporal stability of individual differences in the acquisition and generalization of fear. Psychophysiology 51(7), pp. 697-705. (10.1111/psyp.12213)
- Thompson, P. M. et al. 2014. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior, pp. 153-82. (10.1007/s11682-013-9269-5)
- Lipp, I., Murphy, K., Wise, R. G. and Caseras, X. 2014. Understanding the contribution of neural and physiological signal variation to the low repeatability of emotion-induced BOLD responses. NeuroImage 86, pp. 335-342. (10.1016/j.neuroimage.2013.10.015)
2013
- Caseras, X. et al. 2013. Anatomical and functional overlap within the insula and anterior cingulate cortex during interoception and phobic symptom provocation. Human Brain Mapping 34(5), pp. 1220-1229. (10.1002/hbm.21503)
- Caseras, X., Lawrence, N. S., Murphy, K., Wise, R. G. and Phillips, M. L. 2013. Ventral striatum activity in response to reward: differences between bipolar I and II disorders. American Journal of Psychiatry 170(5), pp. 533-541. (10.1176/appi.ajp.2012.12020169)
- Torrents-Rodas, D., Fullana, M. A., Bonillo, A., Caseras, X., Andión, O. and Torrubia, R. 2013. No effect of trait anxiety on differential fear conditioning or fear generalization. Biological Psychology 92(2), pp. 185-190. (10.1016/j.biopsycho.2012.10.006)
2012
- Taberner, J., Fullana, M. A., Caseras, X., Pertusa, A., Bados, A., van den Bree, M. B. and Torrubia, R. 2012. Familial predictors of obsessive-compulsive symptom dimensions (contamination/cleaning and symmetry/ordering) in a nonclinical sample. Journal of Clinical Psychology 68(12), pp. 1266-1275. (10.1002/jclp.21861)
- Gutiérrez, F., Vall, G., Peri, J. M., Baillés, E., Ferraz, L., Gárriz, M. and Caseras, X. 2012. Personality disorder features through the life course. Journal of Personality Disorders 26(5), pp. 763-774. (10.1521/pedi.2012.26.5.763)
- Torrents-Rodas, D. et al. 2012. Acquisition and generalization of fear conditioning are not modulated by the BDNF-val66met polymorphism in humans. Psychophysiology 49(5), pp. 713-719. (10.1111/j.1469-8986.2011.01352.x)
- Calvo, N., Gutierrez, F., Andion, O., Caseras, X., Torrubia, R. and Casas, M. 2012. Psychometric properties of the Spanish version of the self-report Personality Diagnostic Questionnaire -4+ (PDQ-4+) in psychiatric outpatients. Psicothema -Oviedo- 24(1), pp. 156-160.
2010
- Caseras, X. et al. 2010. The functional neuroanatomy of blood-injection-injury phobia: a comparison with spider phobics and healthy controls. Psychological Medicine 40(1), pp. 125-134. (10.1017/S0033291709005972)
- Caseras, X. et al. 2010. Dynamics of brain responses to phobic-related stimulation in specific phobia subtypes. European Journal of Neuroscience 32(8), pp. 1414-1422. (10.1111/j.1460-9568.2010.07424.x)
2009
- Taberner, J. et al. 2009. Are obsessive-compulsive symptom dimensions familial in nonclinical individuals?. Depression and Anxiety 26(10), pp. 902-908. (10.1002/da.20606)
- Pinto-Meza, A., Suárez, D., Caseras, X., Haro, J. M., Serrano-Blanco, A. and Torrubia, R. 2009. Evaluación telefónica de los sistemas de activación e inhibición conductual. Revista de Psiquiatria y Salud Mental 2(2), pp. 66-71. (10.1016/S1888-9891(09)72247-5)
- Carrillo-de-la-Peña, M., Baillès, E., Caseras, X., Martínez, ?., Ortet, G. and Pérez, J. 2009. Formative assessment and academic achievement in pre-graduate students of health sciences. Advances in Health Sciences Education 14(1), pp. 61-67. (10.1007/s10459-007-9086-y)
- Pinto-Meza, A., Suárez, D., Caseras, X., Haro, J. M., Serrano-Blanco, A. and Torrubia, R. 2009. Evaluation of behavioural activation and inhibition systems by telephone. Revista de Psiquiatría y Salud Mental 2(2), pp. 66-71.
2008
- Caseras, X. et al. 2008. The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome. Psychological Medicine 38(7), pp. 941-951. (10.1017/S0033291708003450)
- Calvo, N., Andion, O., Ferrer, M., Caseras, X. and Torrubia, R. 2008. Screening of personality disorders for gender among Spanish college students by personality diagnostic questionnaire-4+ (Pdq-4+) [Abstract]. European Psychiatry 23(S2), pp. S92-S93. (10.1016/j.eurpsy.2008.01.708)
- Mataix-Cols, D. et al. 2008. Individual differences in disgust sensitivity modulate neural responses to aversive/disgusting stimuli. European Journal of Neuroscience 27(11), pp. 3050-3058. (10.1111/j.1460-9568.2008.06311.x)
2007
- Fullana, M. A., Tortella-Feliu, M., Caseras, X., Taberner, J., Torrubia, R. and Mataix-Cols, D. 2007. Temporal stability of obsessive-compulsive symptom dimensions in an undergraduate sample: a prospective 2-year follow-up study. Behavior Modification 31(6), pp. 815-824. (10.1177/0145445507301649)
- Gutiérrez, F., Peri, J. M., Torres, X., Caseras, X. and Valdés, M. 2007. Three dimensions of coping and a look at their evolutionary origin. Journal of Research in Personality 41(5), pp. 1032-1053. (10.1016/j.jrp.2007.01.006)
- Caseras, X. et al. 2007. Sex differences in neural responses to disgusting visual stimuli: implications for disgust-related psychiatric disorders. Biological Psychiatry 62(5), pp. 464-471. (10.1016/j.biopsych.2006.10.030)
- Caseras, X., Garner, M., Bradley, B. P. and Mogg, K. 2007. Biases in visual orienting to negative and positive scenes in dysphoria: An eye movement study. Journal of Abnormal Psychology 116(3), pp. 491-497. (10.1037/0021-843X.116.3.491)
- Salavert, J., Caseras, X., Torrubia, R., Furest, S., Arranz, B., Dueñas, R. and San, L. 2007. The functioning of the Behavioral Activation and Inhibition Systems in bipolar I euthymic patients and its influence in subsequent episodes over an eighteen-month period. Personality and Individual Differences 42(7), pp. 1323-1331. (10.1016/j.paid.2006.10.010)
- Salavert, J., Caseras, X., Torrubia, R., Ramírez, N., Del Moral, E., Arranz, B. and San, L. 2007. Behavioral activation and inhibition systems in bipolar i euthymic patients and its influence in subsequent episodes. European Psychiatry 22(Supp1), pp. S258-S258. (10.1016/j.eurpsy.2007.01.867)
2006
- Caseras, X. et al. 2006. Probing the working memory system in Chronic Fatigue Syndrome: a functional magnetic resonance imaging study using the n-back task. Psychosomatic Medicine 68(6), pp. 947-955. (10.1097/01.psy.0000242770.50979.5f)
- Caseras, X., Fullana, M. A., Riba, J., Barbanoj, M. J., Aluja, A. and Torrubia, R. 2006. Influence of individual differences in the Behavioral Inhibition System and stimulus content (fear versus blood-disgust) on affective startle reflex modulation. Biological Psychology 72(3), pp. 251-256. (10.1016/j.biopsycho.2005.10.009)
- Fullana, M., Caseras, X., Riba, J., Barbanoj, M. and Torrubia, R. 2006. Influence of individual differences in Behavioral Inhibition System on the magnitude and time course of the fear-potentiated startle. International Journal of Psychophysiology 60(3), pp. 323-329. (10.1016/j.ijpsycho.2005.07.008)
- Pinto-Meza, A., Caseras, X., Soler, J., Puigdemont, D., Pérez, V. and Torrubia, R. 2006. Behavioural Inhibition and Behavioural Activation Systems in current and recovered major depression participants. Personality and Individual Differences 40(2), pp. 215-226. (10.1016/j.paid.2005.06.021)
- Tortella-Feliu, M., Fullana, M. A., Caseras, X., Andion, O., Torrubia, R. and Mataix-Cols, D. 2006. Spanish version of the savings inventory-revised adaptation, psychometric properties, and relationship to personality variables. Behavior Modification 30(5), pp. 693-712. (10.1177/0145445505278326)
2005
- Fullana, M. A., Tortella-Feliu, M., Caseras, X., Andión, ?., Torrubia, R. and Mataix-Cols, D. 2005. Psychometric properties of the Spanish version of the Obsessive-Compulsive Inventory - revised in a non-clinical sample. Journal of Anxiety Disorders 19(8), pp. 893-903. (10.1016/j.janxdis.2004.10.004)
2004
- Fullana, M. A., Mataix-Cols, D., Caseras, X., Alonso, P., Manuel Menchón, J., Vallejo, J. and Torrubia, R. 2004. High sensitivity to punishment and low impulsivity in obsessive-compulsive patients with hoarding symptoms. Psychiatry Research 129(1), pp. 21-27. (10.1016/j.psychres.2004.02.017)
- Fullana, M. ?. et al. 2004. Personality characteristics in obsessive-compulsive disorder and individuals with subclinical obsessive-compulsive problems. British journal of clinical psychology 43(4), pp. 387-398. (10.1348/0144665042388937)
2003
- Lazaro, C., Caseras, X., Torrubia, R. and Banos, J. E. 2003. [Measurement of postoperative pain: analysis of the sensitivity of various self-evaluation instruments]. Revista Espanola Anestesiologia y reanimacion 50(5), pp. 230-236.
- Lazaro, C., Caseras, X., Torrubia, R. and Banos, J. 2003. [Measurement of postoperative pain: analysis of the sensitivity of various self-evaluation instruments].. Revista espanola de anestesiologia y reanimacion 50(5), pp. 230-236.
- Fullana, M. A., Servera, M., Weems, C. F., Tortella-Feliu, M. and Caseras, X. 2003. Psychometric properties of the Childhood Anxiety Sensitivity Index in a sample of Catalan school children. Anxiety, Stress & Coping 16(1), pp. 99-107. (10.1080/1061580021000009647)
- Lazaro, C., Caseras, X. and Banos, J. E. 2003. Postherpetic neuralgia: a descriptive analysis of patients seen in pain clinics. Regional Anesthesia and Pain Medicine 28(4), pp. 315-320. (10.1016/S1098-7339(03)00178-0)
- Caseras, X., Àvila, C. and Torrubia, R. 2003. The measurement of individual differences in Behavioural Inhibition and Behavioural Activation systems: a comparison of personality scales. Personality and Individual Differences 34(6), pp. 999-1013. (10.1016/S0191-8869(02)00084-3)
- Fullana, M. A., Caseras, X. and Torrubia, R. 2003. Psychometric properties of the personal state questionnaire in a Catalan sample. Personality and Individual Differences 34(4), pp. 605-611. (10.1016/S0191-8869(02)00033-8)
2001
- Lázaro, C. et al. 2001. Psychometric properties of a Spanish version of the McGill pain questionnaire in several Spanish-speaking countries. The Clinical Journal of Pain 17(4), pp. 365-374. (10.1097/00002508-200112000-00012)
- Torrubia, R., Ávila, C., Moltó, J. and Caseras, X. 2001. The sensitivity to punishment and sensitivity to reward questionnaire (SPSRQ) as a measure of Gray's anxiety and impulsivity dimensions. Personality and Individual Differences 31(6), pp. 837-862. (10.1016/S0191-8869(00)00183-5)
- Caseras, X., Torrubia, R. and Farré, J. M. 2001. Is the Behavioural Inhibition System the core vulnerability for cluster C personality disorders?. Personality and Individual Differences 31(3), pp. 349-359. (10.1016/S0191-8869(00)00141-0)
Articles
- Steventon, J. J. et al. 2023. Menopause age, reproductive span and hormone therapy duration predict the volume of medial temporal lobe brain structures in postmenopausal women. Psychoneuroendocrinology 158, article number: 106393. (10.1016/j.psyneuen.2023.106393)
- Caseras, X., Legge, S., Bracher-Smith, M., Anney, R., Owen, M., Escott-Price, V. and Kirov, G. 2023. Copy Number Variants increasing risk for schizophrenia: shared and distinct effects on brain morphometry and cognitive performance. Biological Psychiatry: Global Open Science 3(4), pp. 902-911. (10.1016/j.bpsgos.2022.10.006)
- Harrison, J. R. et al. 2023. Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults. Brain Communications 5(5), article number: fcad229. (10.1093/braincomms/fcad229)
- Mirza-Davies, A. et al. 2022. The impact of genetic risk for Alzheimer’s disease on the structural brain networks of young adults. Frontiers in Neuroscience 16, article number: 987677. (10.3389/fnins.2022.987677)
- Chambers, T. et al. 2022. Genetic common variants associated with cerebellar volume and their overlap with mental disorders: a study on 33,265 individuals from the UK-Biobank. Molecular Psychiatry 27, pp. 2282-2290. (10.1038/s41380-022-01443-8)
- Ching, C. R. K. et al. 2022. What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA bipolar disorder working group. Human Brain Mapping 43(1), pp. 56-82. (10.1002/hbm.25098)
- Zwarte, S. M. C. et al. 2022. Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder. Human Brain Mapping 43(1), pp. 414-430. (10.1002/hbm.25206)
- Frangou, S. et al. 2022. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years. Human Brain Mapping 43(1), pp. 431-451. (10.1002/hbm.25364)
- Dima, D. et al. 2022. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping 43(1), pp. 452-469. (10.1002/hbm.25320)
- Wierenga, L. M. et al. 2022. Greater male than female variability in regional brain structure across the lifespan. Human Brain Mapping 43(1), pp. 470-499. (10.1002/hbm.25204)
- Silva, A. I. et al. 2021. Analysis of diffusion tensor imaging data from the UK Biobank confirms dosage effect of 15q11.2 copy number variation on white matter and shows association with cognition. Biological Psychiatry 90(5), pp. 307-316. (10.1016/j.biopsych.2021.02.969)
- Chambers, T. et al. 2021. Effects of thyroid status on regional brain volumes: a diagnostic and genetic imaging study in UK Biobank. Journal of Clinical Endocrinology and Metabolism 106(3), pp. 688-696. (10.1210/clinem/dgaa903)
- Caseras, X. et al. 2021. Effects of genomic copy number variants penetrant for schizophrenia on cortical thickness and surface area in healthy individuals: analysis of the UK Biobank. British Journal of Psychiatry 218(2), pp. 104-111. (10.1192/bjp.2020.139)
- Nunes, A. et al. 2020. Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Molecular Psychiatry 25, pp. 2130-2143. (10.1038/s41380-018-0228-9)
- Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in carriers of X-linked ichthyosis-associated genetic deletions in the UK Biobank. Journal of Medical Genetics 57(10), pp. 692-698. (10.1136/jmedgenet-2019-106676)
- Grama, S. et al. 2020. Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort. Translational Psychiatry 10, article number: 309. (10.1038/s41398-020-00940-0)
- Gubb, S., Brcic, L., Underwood, J., Kendall, K., Caseras, X., Kirov, G. and Davies, W. 2020. Medical and neurobehavioural phenotypes in male and female carriers of Xp22.31 duplications in the UK Biobank. Human Molecular Genetics 29(17), pp. 2872-2881. (10.1093/hmg/ddaa174)
- Chandler, H. L., Hodgetts, C. J., Caseras, X., Murphy, K. and Lancaster, T. M. 2020. Polygenic risk for Alzheimer's disease shapes hippocampal scene-selectivity. Neuropsychopharmacology 45, pp. 1171-1178. (10.1038/s41386-019-0595-1)
- Han, L. K. M. et al. 2020. Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. Molecular Psychiatry 26, pp. 5124-5139. (10.1038/s41380-020-0754-0)
- Warland, A., Kendall, K. M., Rees, E., Kirov, G. and Caseras, X. 2020. Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank. Molecular Psychiatry 25(4), pp. 854-862. (10.1038/s41380-019-0355-y)
- Warne, N., Caseras, X. and Rice, F. 2020. The cross-sectional and longitudinal relationship between overgeneral autobiographical memory and adolescent depression in a UK population-based cohort. Journal of Affective Disorders 266, pp. 621-625. (10.1016/j.jad.2020.02.011)
- Grasby, K. L. et al. 2020. The genetic architecture of the human cerebral cortex. Science 367(6484), article number: eaay6690. (10.1126/science.aay6690)
- Favre, P. et al. 2019. Widespread white matter microstructural abnormalities in bipolar disorder: Evidence from mega- and meta-analyses across 3,033 individuals. Neuropsychopharmacology 44, pp. 2285-2293. (10.1038/s41386-019-0485-6)
- Favre, P. et al. 2019. Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals. Neuropsychopharmacology 44, pp. 2285-2293. (10.1038/s41386-019-0485-6)
- de Zwarte, S. M. C. et al. 2019. The association between familial risk and brain abnormalities is disease-specific: an ENIGMA–Relatives study of schizophrenia and bipolar disorder. Biological Psychiatry 86(7), pp. 545-556. (10.1016/j.biopsych.2019.03.985)
- Whittaker, J. R., Foley, S. F., Ackling, E., Murphy, K. and Caseras, X. 2018. The functional connectivity between the nucleus accumbens and the ventromedial prefrontal cortex as an endophenotype for bipolar disorder. Biological Psychiatry 84(11), pp. 803-809. (10.1016/j.biopsych.2018.07.023)
- Foley, S. F., Bracher-Smith, M., Tansey, K. E., Harrison, J., Parker, G. D. and Caseras, X. 2018. Fractional anisotropy of the uncinate fasciculus and cingulum in bipolar disorder type I, type II, their unaffected siblings and healthy controls. British Journal of Psychiatry 213(3), pp. 548-554. (10.1192/bjp.2018.101)
- Salavert, J. et al. 2018. Functional imaging changes in the medial prefrontal cortex in adult ADHD. Journal of Attention Disorders 22(7), pp. 679-693. (10.1177/1087054715611492)
- Andreassen, O. A., Hibar, D. P., Westlye, L. T. and Caseras, X. 2017. Cortical abnormalities in bipolar disorder: An MRI analysis of 6,503 individuals from the ENIGMA-Bipolar Disorder Working Group. Molecular Psychiatry 23, pp. 932-942. (10.1038/mp.2017.73)
- Gutierrez, F. et al. 2017. Psychometric properties of the Spanish PID-5 in a clinical and a community sample. Assessment 24(3), pp. 326-336. (10.1177/1073191115606518)
- Foley, S. F. et al. 2017. Multimodal brain imaging reveals structural differences in Alzheimer's disease polygenic risk carriers: A study in healthy young adults. Biological Psychiatry 81(2), pp. 154-161. (10.1016/j.biopsych.2016.02.033)
- Hibar, D. P. et al. 2016. Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry 21(12), pp. 1710-1716. (10.1038/mp.2015.227)
- Lancaster, T., Foley, S., Tansey, K. E., Linden, D. E. J. and Caseras, X. 2016. CACNA1C risk variant is associated with increased amygdala volume. European Archives of Psychiatry and Clinical Neuroscience 266(3), pp. 269-275. (10.1007/s00406-015-0609-x)
- Caseras, X., Tansey, K. E., Foley, S. and Linden, D. 2015. Association between genetic risk scoring for schizophrenia and bipolar disorder with regional subcortical volumes. Translational Psychiatry 5, article number: e692. (10.1038/tp.2015.195)
- Caseras, X., Murphy, K., Lawrence, N. S., Fuentes-Claramonte, P., Watts, J., Jones, D. K. and Phillips, M. L. 2015. Emotion regulation deficits in euthymic bipolar I versus bipolar II disorder: a functional and diffusion-tensor imaging study. Bipolar Disorders 17(5), pp. 461-470. (10.1111/bdi.12292)
- Lipp, I., Murphy, K., Caseras, X. and Wise, R. G. 2015. Agreement and repeatability of vascular reactivity estimates based on a breath-hold task and a resting state scan. NeuroImage 113, pp. 387-396. (10.1016/j.neuroimage.2015.03.004)
- Lipp, I., Evans, C. J., Lewis, C., Murphy, K., Wise, R. G. and Caseras, X. 2015. The relationship between fearfulness, GABA, and fear-related BOLD responses in the insula. Plos One 10(3), article number: e0120101. (10.1371/journal.pone.0120101)
- Olatunji, B. O. et al. 2014. Predicting response to cognitive behavioral therapy in contamination-based obsessive-compulsive disorder from functional magnetic resonance imaging. Psychological Medicine 44(10), pp. 2125-2137. (10.1017/S0033291713002766)
- Torrents-Rodas, D., Fullana, M. A., Bonillo, A., Andión, O., Molinuevo, B., Caseras, X. and Torrubia, R. 2014. Testing the temporal stability of individual differences in the acquisition and generalization of fear. Psychophysiology 51(7), pp. 697-705. (10.1111/psyp.12213)
- Thompson, P. M. et al. 2014. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior, pp. 153-82. (10.1007/s11682-013-9269-5)
- Lipp, I., Murphy, K., Wise, R. G. and Caseras, X. 2014. Understanding the contribution of neural and physiological signal variation to the low repeatability of emotion-induced BOLD responses. NeuroImage 86, pp. 335-342. (10.1016/j.neuroimage.2013.10.015)
- Caseras, X. et al. 2013. Anatomical and functional overlap within the insula and anterior cingulate cortex during interoception and phobic symptom provocation. Human Brain Mapping 34(5), pp. 1220-1229. (10.1002/hbm.21503)
- Caseras, X., Lawrence, N. S., Murphy, K., Wise, R. G. and Phillips, M. L. 2013. Ventral striatum activity in response to reward: differences between bipolar I and II disorders. American Journal of Psychiatry 170(5), pp. 533-541. (10.1176/appi.ajp.2012.12020169)
- Torrents-Rodas, D., Fullana, M. A., Bonillo, A., Caseras, X., Andión, O. and Torrubia, R. 2013. No effect of trait anxiety on differential fear conditioning or fear generalization. Biological Psychology 92(2), pp. 185-190. (10.1016/j.biopsycho.2012.10.006)
- Taberner, J., Fullana, M. A., Caseras, X., Pertusa, A., Bados, A., van den Bree, M. B. and Torrubia, R. 2012. Familial predictors of obsessive-compulsive symptom dimensions (contamination/cleaning and symmetry/ordering) in a nonclinical sample. Journal of Clinical Psychology 68(12), pp. 1266-1275. (10.1002/jclp.21861)
- Gutiérrez, F., Vall, G., Peri, J. M., Baillés, E., Ferraz, L., Gárriz, M. and Caseras, X. 2012. Personality disorder features through the life course. Journal of Personality Disorders 26(5), pp. 763-774. (10.1521/pedi.2012.26.5.763)
- Torrents-Rodas, D. et al. 2012. Acquisition and generalization of fear conditioning are not modulated by the BDNF-val66met polymorphism in humans. Psychophysiology 49(5), pp. 713-719. (10.1111/j.1469-8986.2011.01352.x)
- Calvo, N., Gutierrez, F., Andion, O., Caseras, X., Torrubia, R. and Casas, M. 2012. Psychometric properties of the Spanish version of the self-report Personality Diagnostic Questionnaire -4+ (PDQ-4+) in psychiatric outpatients. Psicothema -Oviedo- 24(1), pp. 156-160.
- Caseras, X. et al. 2010. The functional neuroanatomy of blood-injection-injury phobia: a comparison with spider phobics and healthy controls. Psychological Medicine 40(1), pp. 125-134. (10.1017/S0033291709005972)
- Caseras, X. et al. 2010. Dynamics of brain responses to phobic-related stimulation in specific phobia subtypes. European Journal of Neuroscience 32(8), pp. 1414-1422. (10.1111/j.1460-9568.2010.07424.x)
- Taberner, J. et al. 2009. Are obsessive-compulsive symptom dimensions familial in nonclinical individuals?. Depression and Anxiety 26(10), pp. 902-908. (10.1002/da.20606)
- Pinto-Meza, A., Suárez, D., Caseras, X., Haro, J. M., Serrano-Blanco, A. and Torrubia, R. 2009. Evaluación telefónica de los sistemas de activación e inhibición conductual. Revista de Psiquiatria y Salud Mental 2(2), pp. 66-71. (10.1016/S1888-9891(09)72247-5)
- Carrillo-de-la-Peña, M., Baillès, E., Caseras, X., Martínez, ?., Ortet, G. and Pérez, J. 2009. Formative assessment and academic achievement in pre-graduate students of health sciences. Advances in Health Sciences Education 14(1), pp. 61-67. (10.1007/s10459-007-9086-y)
- Pinto-Meza, A., Suárez, D., Caseras, X., Haro, J. M., Serrano-Blanco, A. and Torrubia, R. 2009. Evaluation of behavioural activation and inhibition systems by telephone. Revista de Psiquiatría y Salud Mental 2(2), pp. 66-71.
- Caseras, X. et al. 2008. The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome. Psychological Medicine 38(7), pp. 941-951. (10.1017/S0033291708003450)
- Calvo, N., Andion, O., Ferrer, M., Caseras, X. and Torrubia, R. 2008. Screening of personality disorders for gender among Spanish college students by personality diagnostic questionnaire-4+ (Pdq-4+) [Abstract]. European Psychiatry 23(S2), pp. S92-S93. (10.1016/j.eurpsy.2008.01.708)
- Mataix-Cols, D. et al. 2008. Individual differences in disgust sensitivity modulate neural responses to aversive/disgusting stimuli. European Journal of Neuroscience 27(11), pp. 3050-3058. (10.1111/j.1460-9568.2008.06311.x)
- Fullana, M. A., Tortella-Feliu, M., Caseras, X., Taberner, J., Torrubia, R. and Mataix-Cols, D. 2007. Temporal stability of obsessive-compulsive symptom dimensions in an undergraduate sample: a prospective 2-year follow-up study. Behavior Modification 31(6), pp. 815-824. (10.1177/0145445507301649)
- Gutiérrez, F., Peri, J. M., Torres, X., Caseras, X. and Valdés, M. 2007. Three dimensions of coping and a look at their evolutionary origin. Journal of Research in Personality 41(5), pp. 1032-1053. (10.1016/j.jrp.2007.01.006)
- Caseras, X. et al. 2007. Sex differences in neural responses to disgusting visual stimuli: implications for disgust-related psychiatric disorders. Biological Psychiatry 62(5), pp. 464-471. (10.1016/j.biopsych.2006.10.030)
- Caseras, X., Garner, M., Bradley, B. P. and Mogg, K. 2007. Biases in visual orienting to negative and positive scenes in dysphoria: An eye movement study. Journal of Abnormal Psychology 116(3), pp. 491-497. (10.1037/0021-843X.116.3.491)
- Salavert, J., Caseras, X., Torrubia, R., Furest, S., Arranz, B., Dueñas, R. and San, L. 2007. The functioning of the Behavioral Activation and Inhibition Systems in bipolar I euthymic patients and its influence in subsequent episodes over an eighteen-month period. Personality and Individual Differences 42(7), pp. 1323-1331. (10.1016/j.paid.2006.10.010)
- Salavert, J., Caseras, X., Torrubia, R., Ramírez, N., Del Moral, E., Arranz, B. and San, L. 2007. Behavioral activation and inhibition systems in bipolar i euthymic patients and its influence in subsequent episodes. European Psychiatry 22(Supp1), pp. S258-S258. (10.1016/j.eurpsy.2007.01.867)
- Caseras, X. et al. 2006. Probing the working memory system in Chronic Fatigue Syndrome: a functional magnetic resonance imaging study using the n-back task. Psychosomatic Medicine 68(6), pp. 947-955. (10.1097/01.psy.0000242770.50979.5f)
- Caseras, X., Fullana, M. A., Riba, J., Barbanoj, M. J., Aluja, A. and Torrubia, R. 2006. Influence of individual differences in the Behavioral Inhibition System and stimulus content (fear versus blood-disgust) on affective startle reflex modulation. Biological Psychology 72(3), pp. 251-256. (10.1016/j.biopsycho.2005.10.009)
- Fullana, M., Caseras, X., Riba, J., Barbanoj, M. and Torrubia, R. 2006. Influence of individual differences in Behavioral Inhibition System on the magnitude and time course of the fear-potentiated startle. International Journal of Psychophysiology 60(3), pp. 323-329. (10.1016/j.ijpsycho.2005.07.008)
- Pinto-Meza, A., Caseras, X., Soler, J., Puigdemont, D., Pérez, V. and Torrubia, R. 2006. Behavioural Inhibition and Behavioural Activation Systems in current and recovered major depression participants. Personality and Individual Differences 40(2), pp. 215-226. (10.1016/j.paid.2005.06.021)
- Tortella-Feliu, M., Fullana, M. A., Caseras, X., Andion, O., Torrubia, R. and Mataix-Cols, D. 2006. Spanish version of the savings inventory-revised adaptation, psychometric properties, and relationship to personality variables. Behavior Modification 30(5), pp. 693-712. (10.1177/0145445505278326)
- Fullana, M. A., Tortella-Feliu, M., Caseras, X., Andión, ?., Torrubia, R. and Mataix-Cols, D. 2005. Psychometric properties of the Spanish version of the Obsessive-Compulsive Inventory - revised in a non-clinical sample. Journal of Anxiety Disorders 19(8), pp. 893-903. (10.1016/j.janxdis.2004.10.004)
- Fullana, M. A., Mataix-Cols, D., Caseras, X., Alonso, P., Manuel Menchón, J., Vallejo, J. and Torrubia, R. 2004. High sensitivity to punishment and low impulsivity in obsessive-compulsive patients with hoarding symptoms. Psychiatry Research 129(1), pp. 21-27. (10.1016/j.psychres.2004.02.017)
- Fullana, M. ?. et al. 2004. Personality characteristics in obsessive-compulsive disorder and individuals with subclinical obsessive-compulsive problems. British journal of clinical psychology 43(4), pp. 387-398. (10.1348/0144665042388937)
- Lazaro, C., Caseras, X., Torrubia, R. and Banos, J. E. 2003. [Measurement of postoperative pain: analysis of the sensitivity of various self-evaluation instruments]. Revista Espanola Anestesiologia y reanimacion 50(5), pp. 230-236.
- Lazaro, C., Caseras, X., Torrubia, R. and Banos, J. 2003. [Measurement of postoperative pain: analysis of the sensitivity of various self-evaluation instruments].. Revista espanola de anestesiologia y reanimacion 50(5), pp. 230-236.
- Fullana, M. A., Servera, M., Weems, C. F., Tortella-Feliu, M. and Caseras, X. 2003. Psychometric properties of the Childhood Anxiety Sensitivity Index in a sample of Catalan school children. Anxiety, Stress & Coping 16(1), pp. 99-107. (10.1080/1061580021000009647)
- Lazaro, C., Caseras, X. and Banos, J. E. 2003. Postherpetic neuralgia: a descriptive analysis of patients seen in pain clinics. Regional Anesthesia and Pain Medicine 28(4), pp. 315-320. (10.1016/S1098-7339(03)00178-0)
- Caseras, X., Àvila, C. and Torrubia, R. 2003. The measurement of individual differences in Behavioural Inhibition and Behavioural Activation systems: a comparison of personality scales. Personality and Individual Differences 34(6), pp. 999-1013. (10.1016/S0191-8869(02)00084-3)
- Fullana, M. A., Caseras, X. and Torrubia, R. 2003. Psychometric properties of the personal state questionnaire in a Catalan sample. Personality and Individual Differences 34(4), pp. 605-611. (10.1016/S0191-8869(02)00033-8)
- Lázaro, C. et al. 2001. Psychometric properties of a Spanish version of the McGill pain questionnaire in several Spanish-speaking countries. The Clinical Journal of Pain 17(4), pp. 365-374. (10.1097/00002508-200112000-00012)
- Torrubia, R., Ávila, C., Moltó, J. and Caseras, X. 2001. The sensitivity to punishment and sensitivity to reward questionnaire (SPSRQ) as a measure of Gray's anxiety and impulsivity dimensions. Personality and Individual Differences 31(6), pp. 837-862. (10.1016/S0191-8869(00)00183-5)
- Caseras, X., Torrubia, R. and Farré, J. M. 2001. Is the Behavioural Inhibition System the core vulnerability for cluster C personality disorders?. Personality and Individual Differences 31(3), pp. 349-359. (10.1016/S0191-8869(00)00141-0)
Research
My research aims to investigate how learning and emotion processing and regulation might predispose some people to suffer from mental disorders or make others resilient to the same conditions. My research focuses mainly on anxiety and affective disorders and uses functional and structural neuroimaging, psychophysiological (mainly startle reflex) and neuropsychological techniques. We conduct our research in healthy participants in order to better understand basic processes associated with learning and emotion processing and regulation that might be associated with mental illnesses, in clinical populations in order to investigate what makes them different from healthy controls and therefore is potentially associated whit their psychiatric condition, and in at risk populations (eg. young people with specific personality traits associated with vulnerability to anxiety, or first degree relatives of psychiatric patients and therefore at a major genetic risk for the disorder) in order to explore potential vulnerability, but also resilience, factors.
I am also interested in investigating how genetic factors are expressed in the brain and in cognitive/affective processes. To this aim I investigate for example how participants carrying different allelic variations differ in their brain functional responses or in their ability to process or regulate emotions. My research mainly focus on those genes that have shown association with anxiety disorders, depression or bipolar disorder.
Teaching
I am the lead for the BSc Intercalated in Psychology and Medicine. Other than overseeing the delivery of our intercalated route, I do also supervise research projects within the course and deliver lectures on different topics, from practicals on how to prepare a manuscript submission, to theoretical lectrures on anxiety and mood disorders.
I do also regularly supervise PhD and MSc students, and undergraduate and graduate students on placement or short rotations.
Biography
I graduated in Psychology and subsequently obtained a PhD at the Autonomous University of Barcelona. I then enrolled and completed an International MSc in Neurosciences by the Universities of Maastricht and Florence, while training as a Clinical Psychologist.
For a few years I combined my clinical work at the Institute Dexeus Clinic in Barcelona with a part-time associated lectureship at the School of Medicine in the Autonomous University of Barcelona. In 2003 I was awarded a grant to train in experimental psychology in the University of Southampton, which followed with a 2-year postdoc research position at the Institute of Psychiatry/Kings College London to train in brain imaging methods. After a short comeback to my hometown (Barcelona), I was appointed at Cardiff University.
In Cardiff I have mainly focused in my academic/research role, but I still maintain a small clinical dedication (1 session a week) through and honorary contract with the Cardiff and Vale University Health Board.