Dr Gui Feng

Articles

• Baldwin, A. G. et al. 2025. Discovery of MDI-114215: A potent and selective LIMK inhibitor to treat fragile X syndrome. Journal of Medicinal Chemistry 68(1), pp. 719-752. (10.1021/acs.jmedchem.4c02694)
• Carotenuto, P. et al. 2017. Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut 66(7), pp. 1268-1277. (10.1136/gutjnl-2016-312278)
• De Paoli, M. et al. 2015. Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic. Biomarkers 20(5), pp. 328-337. (10.3109/1354750X.2015.1068867)
• Rada, P. et al. 2015. WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Antioxidants & Redox Signaling 22(7), pp. 555-571. (10.1089/ars.2014.6040)
• Zheng, X. F. et al. 2013. Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression. PLoS ONE 8(5), article number: e63967. (10.1371/journal.pone.0063967)
• Jarde, T. et al. 2013. In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. Oncogene 32(7), pp. 883-893. (10.1038/onc.2012.103)
• Rogers, H., Williams, D. W., Feng, G. J., Lewis, M. A. O. and Wei, X. 2013. Role of bacterial lipopolysaccharide in enhancing host immune response to Candida albicans. Clinical and Developmental Immunology 2013, article number: 320168. (10.1155/2013/320168)
• Feng, G. J. et al. 2012. Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology 143(6), pp. 1650-1659. (10.1053/j.gastro.2012.08.047)
• Murdoch, H., Feng, G. J., Bachner, D., Ormiston, L., White, J. H., Richter, D. and Milligan, G. 2004. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail. Journal of Biological Chemistry 280(9), pp. 8208-8220. (10.1074/jbc.M405215200)
• Murdoch, H., Milligan, G., Kellett, E., White, J. H. and Feng, G. J. 2004. Interactions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation. Biochemical Society Transactions 32(5), pp. 878-880. (10.1042/BST0320878)
• Milligan, G., Feng, G. J., Ward, R., Sartania, N., Ramsay, D., McLean, A. and Carrillo, J. 2004. G protein-coupled receptor fusion proteins in drug discovery. Current Pharmaceutical Design 10(17), pp. 1989-2001. (10.2174/1381612043384295)
• Feng, G., Kellett, E., Scorer, C. A., Wilde, J., White, J. H. and Milligan, G. 2003. Selective interactions between helix VIII of the human μ-opioid receptors and the C terminus of periplakin disrupt G protein activation. Journal of Biological Chemistry 278(35), pp. 33400-33407. (10.1074/jbc.M305866200)
• Feng, G. J., Cavalli, A. and Milligan, G. 2002. Engineering a V2 vasopressin receptor agonist- and regulator of G-protein-signaling-sensitive G protein. Analytical Biochemistry 300(2), pp. 212-220. (10.1006/abio.2001.5448)
• Feng, G., Goodridge, H. S., Harnett, M. M., Wei, X. Q., Nikolaev, A. V., Higson, A. P. and Liew, F. -. 1999. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. Journal of Immunolgy 163(12), pp. 6403-6412.
• Piedrafita, D. et al. 1999. Regulation of macrophage IL-12 synthesis by leishmania phosphoglycans. European Journal of Immunology 29(1), pp. 235-244.
• McInnes, I. B., Leung, B. P., Feng, G., Sturrock, R. D., Field, M. and Foo, Y. L. 1998. Reply to - a role for IL-15 in rheumatoid arthritis?. Nature Medicine 4, pp. 643-643. (10.1038/nm0698-643b)
• Proudfoot, L., Nikolaev, A. V., Feng, G. J., Wei, X., Ferguson, M. A. J., Brimacombe, J. S. and Liew, F. Y. 1996. Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proceedings Of The National Academy Of Sciences Of The United States Of America 93(20), pp. 10984-10989.
• Huang, F. P., Feng, G. J., Lindop, G., Stott, D. I. and Liew, F. W. 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLMP-lprlpr mice. Journal of Experimental Medicine 183(4), pp. 1447-1459. (10.1084/jem.183.4.1447)
• Wei, X. et al. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase [Letter]. Nature 375(6530), pp. 408-411. (10.1038/375408a0)
• Zhao, D., Feng, G., Wu, X. and Zuo, Q. 1985. Seizures induced by intraventricular microinjection of ionised cobalt in the rat -- a new experimental model of epilepsy. Brain Research 342(2), pp. 323-329. (10.1016/0006-8993(85)91132-1)

Book sections

• Menendez-Gonzalez, J. B., Saleh, L., Feng, G. J. and Rodrigues, N. P. 2019. Isolation of murine hematopoietic stem cells. In: Boyd, A. S. ed. Immunological Tolerance: Methods and Protocols., Vol. 1899. Methods in Molecular Biology New York: Humana Press, pp. 15-23., (10.1007/978-1-4939-8938-6_2)
• Milligan, G., Ward, R. J., Feng, G., Carrillo, J. J. and McLean, A. J. 2003. Using receptor-G-Protein chimeras to screen for drugs. In: Bradshaw, R. A. and Dennis, E. A. eds. Handbook of Cell Signaling., Vol. 1. San Diego: Academic Press, pp. 619-621.

• Carotenuto, P. et al. 2017. Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Gut 66(7), pp. 1268-1277. (10.1136/gutjnl-2016-312278)
• Rada, P. et al. 2015. WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes. Antioxidants & Redox Signaling 22(7), pp. 555-571. (10.1089/ars.2014.6040)
• Zheng, X. F. et al. 2013. Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression. PLoS ONE 8(5), article number: e63967. (10.1371/journal.pone.0063967)
• Jarde, T. et al. 2013. In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. Oncogene 32(7), pp. 883-893. (10.1038/onc.2012.103)
• Rogers, H., Williams, D. W., Feng, G. J., Lewis, M. A. O. and Wei, X. 2013. Role of bacterial lipopolysaccharide in enhancing host immune response to Candida albicans. Clinical and Developmental Immunology 2013, article number: 320168. (10.1155/2013/320168)
• Feng, G. J. et al. 2012. Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology 143(6), pp. 1650-1659. (10.1053/j.gastro.2012.08.047)
• Murdoch, H., Feng, G. J., Bachner, D., Ormiston, L., White, J. H., Richter, D. and Milligan, G. 2004. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail. Journal of Biological Chemistry 280(9), pp. 8208-8220. (10.1074/jbc.M405215200)
• Murdoch, H., Milligan, G., Kellett, E., White, J. H. and Feng, G. J. 2004. Interactions between G-protein-coupled receptors and periplakin: a selective means to regulate G-protein activation. Biochemical Society Transactions 32(5), pp. 878-880. (10.1042/BST0320878)
• Milligan, G., Feng, G. J., Ward, R., Sartania, N., Ramsay, D., McLean, A. and Carrillo, J. 2004. G protein-coupled receptor fusion proteins in drug discovery. Current Pharmaceutical Design 10(17), pp. 1989-2001. (10.2174/1381612043384295)
• Feng, G., Kellett, E., Scorer, C. A., Wilde, J., White, J. H. and Milligan, G. 2003. Selective interactions between helix VIII of the human μ-opioid receptors and the C terminus of periplakin disrupt G protein activation. Journal of Biological Chemistry 278(35), pp. 33400-33407. (10.1074/jbc.M305866200)
• Milligan, G., Ward, R. J., Feng, G., Carrillo, J. J. and McLean, A. J. 2003. Using receptor-G-Protein chimeras to screen for drugs. In: Bradshaw, R. A. and Dennis, E. A. eds. Handbook of Cell Signaling., Vol. 1. San Diego: Academic Press, pp. 619-621.
• Feng, G. J., Cavalli, A. and Milligan, G. 2002. Engineering a V2 vasopressin receptor agonist- and regulator of G-protein-signaling-sensitive G protein. Analytical Biochemistry 300(2), pp. 212-220. (10.1006/abio.2001.5448)
• Feng, G., Goodridge, H. S., Harnett, M. M., Wei, X. Q., Nikolaev, A. V., Higson, A. P. and Liew, F. -. 1999. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. Journal of Immunolgy 163(12), pp. 6403-6412.
• Piedrafita, D. et al. 1999. Regulation of macrophage IL-12 synthesis by leishmania phosphoglycans. European Journal of Immunology 29(1), pp. 235-244.
• McInnes, I. B., Leung, B. P., Feng, G., Sturrock, R. D., Field, M. and Foo, Y. L. 1998. Reply to - a role for IL-15 in rheumatoid arthritis?. Nature Medicine 4, pp. 643-643. (10.1038/nm0698-643b)
• Proudfoot, L., Nikolaev, A. V., Feng, G. J., Wei, X., Ferguson, M. A. J., Brimacombe, J. S. and Liew, F. Y. 1996. Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proceedings Of The National Academy Of Sciences Of The United States Of America 93(20), pp. 10984-10989.
• Huang, F. P., Feng, G. J., Lindop, G., Stott, D. I. and Liew, F. W. 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRLMP-lprlpr mice. Journal of Experimental Medicine 183(4), pp. 1447-1459. (10.1084/jem.183.4.1447)
• Wei, X. et al. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase [Letter]. Nature 375(6530), pp. 408-411. (10.1038/375408a0)
• Zhao, D., Feng, G., Wu, X. and Zuo, Q. 1985. Seizures induced by intraventricular microinjection of ionised cobalt in the rat -- a new experimental model of epilepsy. Brain Research 342(2), pp. 323-329. (10.1016/0006-8993(85)91132-1)