Dr Marian Hamshere

2024

• Trastulla, L. et al. 2024. Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications 15, article number: 5534. (10.1038/s41467-024-49338-2)

2023

• Doherty, A., O'Donovan, M., Hamshere, M., Jones, I., Owen, M. and Walters, J. 2023. Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors. The American Journal of Psychiatry 180(10), pp. 723-738. (10.1176/appi.ajp.21121266)

2022

• Hamshere, M. L., Files, C., Davies, W. and Anney, R. 2022. Embedding genomic research into teaching practice: the rewards and potential pitfalls. Genetics Society News 87, pp. 30-31.
• Mullins, N. et al. 2022. Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors. Biological Psychiatry 91(3), pp. 313-327. (10.1016/j.biopsych.2021.05.029)

2020

• Akingbuwa, W. A. et al. 2020. Genetic associations between childhood psychopathology and adult depression and associated traits in 42 998 individuals. JAMA Psychiatry 77(7), pp. 715-728. (10.1001/jamapsychiatry.2020.0527)

2019

• Mulllins, N. et al. 2019. GWAS of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores. American Journal of Psychiatry 176(8), pp. 651-660. (10.1176/appi.ajp.2019.18080957)
• Stahl, E. A. et al. 2019. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics 51, pp. 793-803. (10.1038/s41588-019-0397-8)

2018

• Bakhsh, A. D. et al. 2018. An InDel in Phospholipase-C-B-1 is linked with euthyroid multinodular goiter. Thyroid 28(7), pp. 891-901. (10.1089/thy.2017.0312)
• Ruderfer, D. M. et al. 2018. Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. Cell 173(7), pp. 1705-1715.e16. (10.1016/j.cell.2018.05.046)
• Lynham, A. et al. 2018. Examining cognition across the bipolar / schizophrenia diagnostic spectrum. Journal of Psychiatry and Neuroscience 43(3), article number: 170076. (10.1503/jpn.170076)
• Pardinas, A. F. et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics 50, pp. 381-389. (10.1038/s41588-018-0059-2)
• Allardyce, J. et al. 2018. Association between schizophrenia-related polygenic liability and the occurrence and level of mood-incongruent psychotic symptoms in bipolar disorder. JAMA Psychiatry 75(1), pp. 28-35. (10.1001/jamapsychiatry.2017.3485)

2017

• Legge, S. E. et al. 2017. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Molecular Psychiatry 22, pp. 1502-1508. (10.1038/mp.2016.97)
• Allardyce, J. et al. 2017. Psychosis and the level of mood incongruence in Bipolar Disorder are related to genetic liability for Schizophrenia. [Online]. bioRxiv. Available at: http://dx.doi.org/10.1101/160119
• Witt, S. H. et al. 2017. Genome-wide association study of borderline personality disorder reveals genetic overlap with the bipolar disorder, schizophrenia and major depression. Translational Psychiatry 7, article number: e1155.
• Stergiakouli, E. et al. 2017. Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population. International Journal of Epidemiology 46(2), pp. 421-428. (10.1093/ije/dyw216)
• McLaughlin, R. L. et al. 2017. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications 8, article number: 14774. (10.1038/ncomms14774)

2016

• Pardinas, A. et al. 2016. Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection. [Online]. bioRxiv. (10.1101/068593) Available at: http://dx.doi.org/10.1101/068593
• Legge, S. et al. 2016. Reasons for discontinuing clozapine: a cohort study of patients commencing treatment. Schizophrenia Research 174, pp. 113-119. (10.1016/j.schres.2016.05.002)
• Thompson, J. V. et al. 2016. Antipsychotic polypharmacy and augmentation strategies prior to clozapine initiation: a historical cohort study of 310 adults with treatment-resistant schizophrenic disorders. Journal of Psychopharmacology 30(5), pp. 436-443. (10.1177/0269881116632376)
• Franke, B. et al. 2016. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience 19(3), pp. 420-431. (10.1038/nn.4228)

2015

• Lee, S. H. et al. 2015. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology 44(5), pp. 1706-1721. (10.1093/ije/dyv136)
• Vilhjálmsson, B. et al. 2015. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. American Journal of Human Genetics 97(4), pp. 576-592. (10.1016/j.ajhg.2015.09.001)
• Østergaard, S. D. et al. 2015. Associations between potentially modifiable risk factors and Alzheimer disease: A mendelian randomization study. PLOS MEDICINE 12(6), pp. e1001841., article number: e1001841. (10.1371/journal.pmed.1001841)
• Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 56(6), pp. 648-656. (10.1111/jcpp.12336)
• Hosp, F. et al. 2015. Quantitative interaction proteomics of neurodegenerative disease proteins. Cell Reports 11(7), pp. 1134-46. (10.1016/j.celrep.2015.04.030)
• Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
• O'Dushlaine, C. et al. 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 18(2), pp. 199-209. (10.1038/nn.3922)
• Maier, R. et al. 2015. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. American Journal of Human Genetics 96(2), pp. 283-294. (10.1016/j.ajhg.2014.12.006)

2014

• Gusev, A. et al. 2014. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. American Journal of Human Genetics 95(5), pp. 535-552. (10.1016/j.ajhg.2014.10.004)
• Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2014. Genetic risk for Attention Deficit/Hyperactivity Disorder contributes to neurodevelopmental traits in the general population. Biological Psychiatry 76(8), pp. 664-671. (10.1016/j.biopsych.2014.02.013)
• Jamain, S. et al. 2014. Common and rare variant analysis in early-onset bipolar disorder vulnerability. PLoS ONE 9(8), article number: e104326. (10.1371/journal.pone.0104326)
• Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53(7), pp. 761-770.e26. (10.1016/j.jaac.2014.03.004)
• Ripke, S. et al. 2014. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511(7510), pp. 421-427. (10.1038/nature13595)
• Liu, G. et al. 2014. Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies. Neurobiology of Aging 35(4), pp. 786-92. (10.1016/j.neurobiolaging.2013.10.084)
• Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. 2014. Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry 23(1), pp. 23-24. (10.1007/s00787-013-0398-6)
• Martin, J., Hamshere, M. L., O'Donovan, M. C., Rutter, M. and Thapar, A. 2014. Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders 44(1), pp. 204-215. (10.1007/s10803-013-1865-0)

2013

• Green, E. K. et al. 2013. Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. Molecular Psychiatry 18(12), pp. 1302-1307. (10.1038/mp.2012.142)
• van Scheltinga, A. F. T. et al. 2013. Schizophrenia genetic variants are not associated with intelligence. Psychological Medicine 43(12), pp. 2563-2570. (10.1017/S0033291713000196)
• Zammit, S. et al. 2013. A population-based study of genetic variation and psychotic experiences in adolescents. Schizophrenia Bulletin 40(6), pp. 1254-1262. (10.1093/schbul/sbt146)
• Lee, S. et al. 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45(9), pp. 984-994. (10.1038/ng.2711)
• Ripke, S. et al. 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics 45(10), pp. 1150-1159. (10.1038/ng.2742)
• Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
• Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
• Hamshere, M. L. et al. 2013. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Molecular Psychiatry 18(6), pp. 708-712. (10.1038/mp.2012.67)
• Zou, F. et al. 2013. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's Disease pathology. PLoS ONE 8(5), article number: e64802. (10.1371/journal.pone.0064802)
• Terwisscha van Scheltinga, A. F. et al. 2013. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry 73(6), pp. 525-531. (10.1016/j.biopsych.2012.08.017)
• Green, E. K. et al. 2013. Association at SYNE1 in both bipolar disorder and recurrent major depression. Molecular Psychiatry 18, pp. 614-617. (10.1038/mp.2012.48)

2012

• Eyre, S. et al. 2012. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics 44(12), pp. 1336-1340. (10.1038/ng.2462)
• Goes, F. S. et al. 2012. Genome-wide association of mood-incongruent psychotic bipolar disorder. Translational Psychiatry 2(10), article number: e180. (10.1038/tp.2012.106)
• Hamilton, G. et al. 2012. The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B(6), pp. 696-709. (10.1002/ajmg.b.32073)
• Badner, J. A. et al. 2012. Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Molecular Psychiatry 17(8), pp. 818-826. (10.1038/mp.2011.89)
• Shi, H. et al. 2012. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging 33(8), article number: 1849.e5. (10.1016/j.neurobiolaging.2012.02.014)
• Hamilton, G. et al. 2012. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiology of Aging 33(8), article number: 1848.e1. (10.1016/j.neurobiolaging.2012.02.005)
• Derks, E. M. et al. 2012. Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis. PLoS ONE 7(6), article number: e37852. (10.1371/journal.pone.0037852)
• Hudson, G. et al. 2012. No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology 78(14), pp. 1038-1042. (10.1212/WNL.0b013e31824e8f1d)
• Keller, M. C. et al. 2012. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. Plos Genetics 8(4), article number: e1002656. (10.1371/journal.pgen.1002656)
• Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
• Gerrish, A. et al. 2012. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's Disease. Journal of Alzheimer's Disease 28(2), pp. 377-387. (10.3233/JAD-2011-110824)

2011

• Cardno, A. G. et al. 2011. A genomewide linkage study of age at onset in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(8), pp. 929-940. (10.1002/ajmg.1404)
• Sklar, P. et al. 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 [Letter]. Nature Genetics 43(10), pp. 977-983. (10.1038/ng.943)
• Ripke, S. et al. 2011. Genome-wide association study identifies five new schizophrenia loci [Letter]. Nature Genetics 43(10), pp. 969-976. (10.1038/ng.940)
• Hollingworth, P. et al. 2011. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics 43(5), pp. 429-435. (10.1038/ng.803)
• Ikeda, M. et al. 2011. Genome-Wide Association Study of Schizophrenia in a Japanese Population. Biological Psychiatry 69(5), pp. 472-478. (10.1016/j.biopsych.2010.07.010)
• Reilly, M. P. et al. 2011. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. The Lancet 377(9763), pp. 383-392. (10.1016/S0140-6736(10)61996-4)
• Williams, H. J. et al. 2011. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Human Molecular Genetics 20(2), pp. 387-391. (10.1093/hmg/ddq471)
• Hamshere, M. L. et al. 2011. Polygenic dissection of the bipolar phenotype. British Journal of Psychiatry 198(4), pp. 284-288. (10.1192/bjp.bp.110.087866)
• Belmonte Mahon, P. et al. 2011. Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(3), pp. 370-378. (10.1002/ajmg.b.31172)
• Hamshere, M. L. et al. 2011. Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 929-940. (10.1002/ajmg.b.31240)
• Cichon, S. et al. 2011. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. American Journal of Human Genetics 88(3), pp. 372-381. (10.1016/j.ajhg.2011.01.017)

2010

• Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype [Corrigendum]. Molecular Psychiatry 15(11), pp. 1121-1121. (10.1038/mp.2010.62)
• Jones, L. et al. 2010. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS ONE 5(11), article number: e13950. (10.1371/journal.pone.0013950)
• Green, E. K. et al. 2010. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Molecular Psychiatry 15(10), pp. 1016-1022. (10.1038/mp.2009.49)
• Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Molecular Psychiatry 15(2), pp. 146-153. (10.1038/mp.2008.66)
• Green, E. K. et al. 2010. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(7), pp. 1347-1349. (10.1002/ajmg.b.31108)
• Di Florio, A. et al. 2010. Affective temperaments across the bipolar-unipolar spectrum: examination of the TEMPS-A in 927 patients and controls. Journal of affective disorders 123(1-3), pp. 42-51. (10.1016/j.jad.2009.09.020)
• Liu, Y. et al. 2010. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder [Letter]. Molecular Psychiatry 16(1), pp. 2-4. (10.1038/mp.2009.107)
• Breuer, R. et al. 2010. Independent evidence for the selective influence of GABAA receptors on one component of the bipolar disorder phenotype [letter]. Molecular Psychiatry 16(6), pp. 587-589. (10.1038/mp.2010.67)
• Perlis, R. H. et al. 2010. Genome-wide association study of suicide attempts in mood disorder patients. American Journal of Psychiatry 167(12), pp. 1499-1507. (10.1176/appi.ajp.2010.10040541)

2009

• Harold, D. et al. 2009. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Letter]. Nature Genetics 41(10), pp. 1088-1093. (10.1038/ng.440)
• Orozco, G. et al. 2009. Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Human Molecular Genetics 18(14), pp. 2693-2699. (10.1093/hmg/ddp193)
• Butler, A. W. et al. 2009. Meta-analysis of linkage studies for Alzheimer's disease-A web resource. Neurobiology of Aging 30(7), pp. 1037-1047. (10.1016/j.neurobiolaging.2009.03.013)
• O'Donovan, M. C. et al. 2009. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry 14(1), pp. 30-36. (10.1038/mp.2008.108)
• Hamshere, M. L. et al. 2009. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. British Journal of Psychiatry 195(1), pp. 23-29. (10.1192/bjp.bp.108.061424)
• Harold, D. et al. 2009. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Corrigendum]. Nature Genetics 41(10), pp. 1156. (10.1038/ng1009-1156d)
• Hamshere, M. L. et al. 2009. Age-at-onset in bipolar-I disorder: mixture analysis of 1369 cases identifies three distinct clinical sub-groups. Journal of affective disorders 116(1-2), pp. 23-29. (10.1016/j.jad.2008.10.021)
• Hamshere, M. L. et al. 2009. Mood-incongruent psychosis in bipolar disorder: conditional linkage analysis shows genome-wide suggestive linkage at 1q32.3, 7p13 and 20q13.31. Bipolar Disorders 11(6), pp. 610-620. (10.1111/j.1399-5618.2009.00736.x)
• Blom, E. S. et al. 2009. Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs. BMC Medical Genetics 10, pp. 1-6., article number: 122. (10.1186/1471-2350-10-122)

2008

• Barton, A. et al. 2008. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics 40(10), pp. 1156-1159. (10.1038/ng.218)
• Ferreira, M. A. R. et al. 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 40(9), pp. 1056-1058. (10.1038/ng.209)
• Barton, A. et al. 2008. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Human Molecular Genetics 17(15), pp. 2274-2279. (10.1093/hmg/ddn128)
• Loos, R. J. F. et al. 2008. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 40(6), pp. 768-775. (10.1038/ng.140)
• Fisher, S. A. et al. 2008. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics 40(6), pp. 710-712. (10.1038/ng.145)
• Blom, E. S. et al. 2008. Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(6), pp. 778-783. (10.1002/ajmg.b.30681)
• Baum, A. E. et al. 2008. Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement [Letter]. Molecular Psychiatry 13(5), pp. 466-467. (10.1038/mp.2008.16)
• O'Donovan, M. C. et al. 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics 40(9), pp. 1053-1055. (10.1038/ng.201)

2007

• Glaser, B., Nikolov, I., Chubb, D., Hamshere, M. L., Segurado, R., Escott-Price, V. and Holmans, P. A. 2007. Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests [Conference Proceedings]. BMC Proceedings 1(S1), pp. S54-S54.
• Segurado, R., Hamshere, M. L., Glaser, B., Nikolov, I., Escott-Price, V. and Holmans, P. A. 2007. Combining linkage data sets for meta-analysis and mega-analysis: the GAW15 rheumatoid arthritis data set [Conference Proceedings]. BMC Proceedings 1(S1), pp. S104-S104.
• Hamshere, M. L., Segurado, R., Escott-Price, V., Nikolov, I., Glaser, B. and Holmans, P. A. 2007. Large-scale linkage analysis of 1302 affected relative pairs with rheumatoid arthritis [Conference Proceedings]. BMC Proceedings 1(S1), pp. S100-S100.
• Nejentsev, S. et al. 2007. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450(7171), pp. 887-892. (10.1038/nature06406)
• Thomson, W. et al. 2007. Rheumatoid arthritis association at 6q23. Nature Genetics 39(12), pp. 1431-1433. (10.1038/ng.2007.32)
• Hollingworth, P. et al. 2007. Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(7), pp. 841-848. (10.1002/ajmg.b.30515)
• Hamshere, M. L. et al. 2007. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics Advanc, pp. 1-34. (10.1093/hmg/ddm224)
• Jones, I. R. et al. 2007. Bipolar affective puerperal psychosis: genome-wide significant evidence for linkage to chromosome 16. American journal of psychiatry 164(7), pp. 1099-1104. (10.1176/appi.ajp.164.7.1099)
• Burton, P. R. et al. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145), pp. 661-678. (10.1038/nature05911)
• Kaleem, M., Zhao, A., Hamshere, M. L. and Myers, A. 2007. Identification of a novel valosin-containing protein polymorphism in late-onset Alzheimer's disease. Neurodegenerative Diseases 4(5), pp. 376-381. (10.1159/000105158)
• Ghosh, S., Babron, M., Group 10, ., Hamshere, M. L. and Holmans, P. A. 2007. Linkage analyses of rheumatoid arthritis and related quantitative phenotypes: the GAW15 experience. Genetic Epidemiology 31(S1), pp. S86-S95. (10.1002/gepi.20284)
• Burton, P. R. et al. 2007. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics 39(11), pp. 1329-1337. (10.1038/ng.2007.17)

2006

• Hollingworth, P. et al. 2006. Four Components Describe Behavioral Symptoms in 1,120 Individuals with Late-Onset Alzheimer's Disease. Journal of the American Geriatrics Society 54(9), pp. 1348-1354. (10.1111/j.1532-5415.2006.00854.x)
• Williams, N. M. et al. 2006. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Archives of General Psychiatry 63(4), pp. 366-373. (10.1001/archpsyc.63.4.366)
• Lambert, D. et al. 2006. Stage 2 of the Wellcome Trust UK–Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16–q21, 4q12–q21, 9p21, 10p14–p12 and 18q22 - Corrigendum. Molecular Psychiatry 11(12), pp. 1140-1143. (10.1038/sj.mp.4001917)
• Hamshere, M. L. et al. 2006. Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes. Journal of Medical Genetics 43(7), pp. 563-567. (10.1136/jmg.2005.035345)

2005

• Hamshere, M. L., MacGregor, S., Escott-Price, V., Nikolov, I. N. and Holmans, P. A. 2005. Covariate linkage analysis of GAW14 simulated data incorporating subclinical phenotype, sex, population, parent-of-origin, and interaction. BMC Genetics 6(1), pp. S45. (10.1186/1471-2156-6-S1-S45)
• Hamshere, M. L. et al. 2005. Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Archives of general psychiatry 62(10), pp. 1081-1088. (10.1001/archpsyc.62.10.1081)
• Nowotny, P. et al. 2005. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 136B(1), pp. 62-68. (10.1002/ajmg.b.30186)
• Green, E. K. et al. 2005. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Archives of general psychiatry 62(6), pp. 642-648. (10.1001/archpsyc.62.6.642)
• Holmans, P. A. et al. 2005. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B(1), pp. 24-32. (10.1002/ajmg.b.30114)
• Lambert, D. et al. 2005. Stage 2 of the Wellcome Trust UK-Irish bipolar affective disorder sibling-pair genome screen: evidence for linkage on chromosomes 6q16-q21, 4q12-q21, 9p21, 10p14-p12 and 18q22. Molecular psychiatry 10(9), pp. 831-841. (10.1038/sj.mp.4001684)
• McQueen, M. B. et al. 2005. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. American Journal of Human Genetics 77(4), pp. 582-595. (10.1086/491603)

2004

• Myers, A. J. et al. 2004. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics 124B(1), pp. 29-37. (10.1002/ajmg.b.20036)
• Cichon, S. et al. 2004. Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nature Genetics 36(8), pp. 783-784. (10.1038/ng0804-783)

2003

• Williams, N. M. et al. 2003. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. The American journal of human genetics 73(6), pp. 1355-1367. (10.1086/380206)
• Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13(2), pp. 107-110. (10.1097/01.ypg.0000056177.32550.a5)
• Turic, D. et al. 2003. Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22. Molecular Psychiatry 8(2), pp. 176-185. (10.1038/sj.mp.4001216)
• Lawson, D. C. et al. 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B(1), pp. 84-89. (10.1002/ajmg.b.10002)

2002

• Myers, A. et al. 2002. Full genome screen for Alzheimer disease: Stage II analysis. American Journal Of Medical Genetics Part A 114(2), pp. 235-244. (10.1002/ajmg.10183)
• Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7(5), pp. 493-502. (10.1038/sj.mp.4001003)
• Williams, N. M. et al. 2002. Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach. Molecular Psychiatry 7(10), pp. 1092-1100. (10.1038/sj.mp.4001188)
• West, A. et al. 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7(9), pp. 962-966. (10.1038/sj.mp.4001129)

2001

• Abraham, R. et al. 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109(6), pp. 646-652. (10.1007/s00439-001-0614-1)
• Hamshere, M. L., Giles, P., Krawczak, M. and Owen, M. J. 2001. Statistical analysis of genotypic association data with HAPMAXII. AMERICAN JOURNAL OF HUMAN GENETICS 69(4), pp. 390-390.
• Jones, G. et al. 2001. Aggressive behaviour in patients with schizophrenia is associated with catechol-O-methyltransferase genotype. British Journal of Psychiatry 179(4), pp. 351-355. (10.1192/bjp.179.4.351)

2000

• Myers, A. et al. 2000. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290(5500), pp. 2304-2305. (10.1126/science.290.5500.2304)
• Morris, D. W. et al. 2000. Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q. Human Molecular Genetics 9(5), pp. 843-848. (10.1093/hmg/9.5.843)
• Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)