Overview
I am a Senior Clinical Lecturer and an Associate Specialist and my interest in medical research stems from translating research into improved patient care.
I am an experienced Chief Investigator of clinical trials and experimental medicine studies in the field of infection, immunity and vaccine strategy.
My research at the Division of Infection and Immunity includes studies examining differential immune responses to vaccines, T cell responses to viruses and vaccines, bacterial infection, anti-microbial resistance and evaluation of novel antimicrobial agents and rapid diagnostics for detecting infection.
I work closely with the Spiller lab and T Cell research lab at Cardiff University and the R&D team at Cardiff and the Vale University health board, Cwm Taf Morgannwg University health board and have an Honorary contract with Public Health Wales. I am supported by Health and Care Research Wales.
As a clinician I work in the field of Sexual health and HIV, at Cwm Taf Morgannwg University health board.
Publication
2024
- Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134(18), article number: e164535. (10.1172/JCI164535)
- Sampson, O. L. et al. 2024. Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents. Frontiers in Immunology 15, article number: 1329805. (10.3389/fimmu.2024.1329805)
2023
- Lee, I. T. et al. 2023. Omicron BA.1-containing mRNA-1273 boosters compared with the original COVID-19 vaccine in the UK: a randomised, observer-blind, active-controlled trial. The Lancet Infectious Diseases 23(9), pp. 1007-1019. (10.1016/S1473-3099(23)00295-5)
- Jay, C. et al. 2023. Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members. Frontiers in Immunology 14, article number: 1248658. (10.3389/fimmu.2023.1248658)
- Sampson, O. et al. 2023. Gonadal androgens are associated with decreased type I interferon production by pDCs and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents. [Online]. bioRxiv: Cold Spring Harbor Laboratory. (10.1101/2023.08.01.551423) Available at: http://dx.doi.org/10.1101/2023.08.01.551423
2022
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
- Sampson, O. et al. 2022. A simple, robust flow cytometry-based whole blood assay for investigating sex differential interferon alpha production by plasmacytoid dendritic cells. Journal of Immunological Methods 504, article number: 113263. (10.1016/j.jim.2022.113263)
2021
- Boostrom, I. et al. 2021. Evaluation of the MYCOPLASMA IST3 urogenital mycoplasma assay in an international multicentre trial. Journal of Antimicrobial Chemotherapy 76(12), pp. 3175-3182. (10.1093/jac/dkab320)
- Sharratt, M. et al. 2021. Defining fluoroquinolone resistance-mediating mutations from non-resistance polymorphisms in Mycoplasma hominis Topoisomerases. Antibiotics 10(11), article number: 1379. (10.3390/antibiotics10111379)
- Chalker, V. J. et al. 2021. Tetracycline resistance mediated by tet(M) has variable integrative conjugative element composition in Mycoplasma hominis isolated in the United Kingdom from 2005-2015.. Antimicrobial Agents and Chemotherapy 65, article number: e02513-20. (10.1128/AAC.02513-20)
2020
- Morris, D. J., Jones, L. C., Davies, R. L., Sands, K., Portal, E. and Spiller, O. B. 2020. MYCO WELL D-ONE detection of Ureaplasma spp. and Mycoplasma hominis in sexual health patients in Wales. European Journal of Clinical Microbiology and Infectious Diseases 39, pp. 2427-2440. (10.1007/s10096-020-03993-7)
- Spiller, O. B., Rees, C. L., Morris, D. J., Davies, R. L. and Jones, L. C. 2020. Mycoplasma genitalium prevalence in Welsh sexual health patients: low antimicrobial resistance markers and no association of symptoms to bacterial load. Microbial Pathogenesis 139, article number: 103872. (10.1016/j.micpath.2019.103872)
2019
- Beeton, M. L., Payne, M. S. and Jones, L. 2019. The role of Ureaplasma spp. in the development of Nongonococcal Urethritis and infertility among Men. Clinical Microbiology Reviews 32(4) (10.1128/cmr.00137-18)
2016
- Beeton, M. L., Chalker, V. J., Jones, L. C., Maxwell, N. C. and Spiller, O. B. 2016. Antibiotic resistance among clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013. Antimicrobial Agents and Chemotherapy 60(1), pp. 52-56. (10.1128/AAC.00889-15)
2002
- Jones, L., Lopez-Bendito, G., Gruss, P., Stoykova, A. and Molnar, Z. 2002. Pax6 is required for the normal development of the forebrain axonal connections. Development 129(21), pp. 5041–5052. (10.1242/dev.129.21.5041)
2001
- Clark, A. and Jones, L. C. 2001. Decreased insulin secretion in Type 2 diabetes a problem of cellular mass or function?. Presented at: Diabetes, Nice, February 2001, Vol. 50. Vol. Supp 1. American Diabetes Association, (10.2337/diabetes.50.2007.S169)
- Clark, A., Jones, L., de Koning, E., Hansen, B. C. and Matthews, D. R. 2001. Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?. Diabetes 50(1), article number: S169. (10.2337/diabetes.50.2007.S169)
- Jones, L. C. and Clark, A. 2001. beta-cell neogenesis in type 2 diabetes.. Diabetes 50(1), article number: S186. (10.2337/diabetes.50.2007.S186)
Articles
- Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134(18), article number: e164535. (10.1172/JCI164535)
- Sampson, O. L. et al. 2024. Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents. Frontiers in Immunology 15, article number: 1329805. (10.3389/fimmu.2024.1329805)
- Lee, I. T. et al. 2023. Omicron BA.1-containing mRNA-1273 boosters compared with the original COVID-19 vaccine in the UK: a randomised, observer-blind, active-controlled trial. The Lancet Infectious Diseases 23(9), pp. 1007-1019. (10.1016/S1473-3099(23)00295-5)
- Jay, C. et al. 2023. Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members. Frontiers in Immunology 14, article number: 1248658. (10.3389/fimmu.2023.1248658)
- Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
- Sampson, O. et al. 2022. A simple, robust flow cytometry-based whole blood assay for investigating sex differential interferon alpha production by plasmacytoid dendritic cells. Journal of Immunological Methods 504, article number: 113263. (10.1016/j.jim.2022.113263)
- Boostrom, I. et al. 2021. Evaluation of the MYCOPLASMA IST3 urogenital mycoplasma assay in an international multicentre trial. Journal of Antimicrobial Chemotherapy 76(12), pp. 3175-3182. (10.1093/jac/dkab320)
- Sharratt, M. et al. 2021. Defining fluoroquinolone resistance-mediating mutations from non-resistance polymorphisms in Mycoplasma hominis Topoisomerases. Antibiotics 10(11), article number: 1379. (10.3390/antibiotics10111379)
- Chalker, V. J. et al. 2021. Tetracycline resistance mediated by tet(M) has variable integrative conjugative element composition in Mycoplasma hominis isolated in the United Kingdom from 2005-2015.. Antimicrobial Agents and Chemotherapy 65, article number: e02513-20. (10.1128/AAC.02513-20)
- Morris, D. J., Jones, L. C., Davies, R. L., Sands, K., Portal, E. and Spiller, O. B. 2020. MYCO WELL D-ONE detection of Ureaplasma spp. and Mycoplasma hominis in sexual health patients in Wales. European Journal of Clinical Microbiology and Infectious Diseases 39, pp. 2427-2440. (10.1007/s10096-020-03993-7)
- Spiller, O. B., Rees, C. L., Morris, D. J., Davies, R. L. and Jones, L. C. 2020. Mycoplasma genitalium prevalence in Welsh sexual health patients: low antimicrobial resistance markers and no association of symptoms to bacterial load. Microbial Pathogenesis 139, article number: 103872. (10.1016/j.micpath.2019.103872)
- Beeton, M. L., Payne, M. S. and Jones, L. 2019. The role of Ureaplasma spp. in the development of Nongonococcal Urethritis and infertility among Men. Clinical Microbiology Reviews 32(4) (10.1128/cmr.00137-18)
- Beeton, M. L., Chalker, V. J., Jones, L. C., Maxwell, N. C. and Spiller, O. B. 2016. Antibiotic resistance among clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013. Antimicrobial Agents and Chemotherapy 60(1), pp. 52-56. (10.1128/AAC.00889-15)
- Jones, L., Lopez-Bendito, G., Gruss, P., Stoykova, A. and Molnar, Z. 2002. Pax6 is required for the normal development of the forebrain axonal connections. Development 129(21), pp. 5041–5052. (10.1242/dev.129.21.5041)
- Clark, A., Jones, L., de Koning, E., Hansen, B. C. and Matthews, D. R. 2001. Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?. Diabetes 50(1), article number: S169. (10.2337/diabetes.50.2007.S169)
- Jones, L. C. and Clark, A. 2001. beta-cell neogenesis in type 2 diabetes.. Diabetes 50(1), article number: S186. (10.2337/diabetes.50.2007.S186)
Conferences
- Clark, A. and Jones, L. C. 2001. Decreased insulin secretion in Type 2 diabetes a problem of cellular mass or function?. Presented at: Diabetes, Nice, February 2001, Vol. 50. Vol. Supp 1. American Diabetes Association, (10.2337/diabetes.50.2007.S169)
Websites
- Sampson, O. et al. 2023. Gonadal androgens are associated with decreased type I interferon production by pDCs and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents. [Online]. bioRxiv: Cold Spring Harbor Laboratory. (10.1101/2023.08.01.551423) Available at: http://dx.doi.org/10.1101/2023.08.01.551423
Research
Current CI research projects include:
'IRFLUVA - Improving the long term immune response to the flu vaccine in older people' ( Dr Lucy Jones, Professor Katja Simon, Dr Ghada Alsaleh, Professor Paul Klenerman, Professor Teresa Lambe, Professor Andrew Sewell and Dr Brad Spiller) University of Oxford and Cardiff University. A randomised controlled, double blinded pilot study to determine the safety of daily nutritional supplements following vaccination for influenza - Portfolio study. 2023 - ongoing.
'COVID MEMORY' Study ( Dr Lucy Jones, Professor Katja Simon, Dr Ghada Alsaleh, Professor Paul Klenerman, Professor Teresa Lambe and Dr Brad Spiller) University of Oxford and Cardiff University. A randomised controlled, double blinded pilot study to determine the safety of daily nutritional supplements following vaccination for Coronavirus - 2022 and ongoing.
The CROWN Study – 'Characterisation of the Immune Response to SARS-CoV2 Infection'. (Dr Lucy Jones, Professor Andrew Sewell, Professor Paul Klenerman, Professor Mary Carrington, Dr Brad Spiller) 2020 – 2023. Cwm Taf Morgannwg, University of Oxford, Cardiff University and NIH (USA).
'Characterisation of the Immune Response to SARS-CoV2 Infection in Type 1 diabetes'. (Professor Andrew Sewell, Dr Lucy Jones, Professor John Geen, Professor Philip Goulder, Dr Brad Spiller and Dr Karen Logan) Cwm Taf Morgannwg University health board, Cardiff University, University of Oxford and Imperial College - ongoing.
A Phase 2/3 RCT of reactogenicity of MODERNA COVID OMICRON booster vaccine
Principal Investigator for the All Wales Vaccine Research Taskforce and Public Health Wales (April 2022 – 2023).
The 'Antibiotic Guardian Study' (Dr Lucy Jones, Dr Brad Spiller and Dr Sarah Maddocks) Cwm Taf Morgannwg, Cardiff University, Cardiff Metropolitan University research study (2019-2023).
'The STRAVINSKY Study' Stratification of Clinically Vulnerable People for COVID-19 Risk Using Antibody Testing (2023-ongoing). Principal Investigator - a portfolio study with University of Oxford, University of Birmingham, Cardiff University and University of Southampton.
Past studies:
SARS-CoV-2 Immunity of Family/Household Members (Dr Lucy Jones, Professor Paul Klenerman, Professor Philip Goulder) University of Oxford. Characterisation of the differential immune responses to SARS-CoV-2 and COVID vaccines in people aged 8 years to 90 years.
The UROGEN WELL D-ONE Study (Dr Lucy Jones and Dr Brad Spiller). Portfolio clinical research study with Cardiff University/Cwm Taf Morgannwg health board.
The MYCOWELL D-ONE Study (Dr Lucy Jones and Dr Brad Spiller) (2019). Portfolio clinical research study Cardiff University/Cwm Taf Morgannwg health board.
Do genitourinary Mycoplasma species cause disease? (Dr Lucy Jones and Ms Rebecca Davies) Portfolio clinical research study Cwm Taf Morgannwg health board. 2019-2020
The role of Pax6 in the development of the forebrain (Dr Lucy Jones and Professor Zoltan Molnar) Pre-clinical laboratory research study at University of Oxford.
Teaching
I teach undergraduate medical students and doctors in training in the field of HIV medicine and sexual health.
I supervise and teach undergraduate students completing a placement training year in Bioscience/Biomedical Sciences during their research modules in the field of infectious disease.
I supervise and teach medical students who decide to study for an intercalated degree in the field of infection and immunity.
Biography
I have a translational and experimental medicine research portfolio which focuses on improving our understanding of infections, vaccination and the corresponding immune response. I also have an interest in developing novel, rapid diagnostics for infection. This includes studies in Cardiff University, University of Oxford, Imperial College, Cardiff and the Vale University health board, Cwm Taf Morgannwg University health board and NIH.
I was born in Wales and raised in the Valleys of South Wales, before studying Medicine and Physiological Sciences at the University of Oxford. Following my medical qualification and training, I went on to complete a doctorate in the Department of Human Anatomy and Genetics, University of Oxford in the field of development and genetics with Dr Zoltan Molnar and Professor Colin Blakemore.
I have worked in Cwm Taf Morgannwg University health board for 19 years and I am an Associate Specialist and the departmental lead for research. I was made an Honorary lecturer at Cardiff University, School of Medicine in 2012 with a teaching role primarily and have now moved to a research focused role and work closely with a clinical research team at the Clinical Research Facility, Cardiff and the Vale University health board and collaborators at Cardiff University, University of Oxford, Imperial College, Cardiff Metropolitan University, University of Birmingham and NIH.
I also have an interest in working with industry to deliver research trials with benefits to patients in Wales and was Principal Investigator for the OMICRON vaccine trial in Wales in my role as an Honorary Associate Specialist with Public Health Wales. I co-supervise post-graduate students and play a role in teaching in the field of infection. I enjoy leading outreach activities in the field of infection and immunity.
Academic positions
Honorary Clinical Lecturer, Cardiff University, 2012-2023.
Supervisions
Infectious diease
Immunology
Microbiology
Clinical trials
Current supervision
Martin Sharratt
Research student
Contact Details
Main Hospital Building, Floor 6th, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
Research themes
Specialisms
- Immunology
- Infectious diseases
- clinical trials
- vaccines
- experimental medicine