Dr Sarah Lauder

2026

• Marsden, M. et al. 2026. Cytomegalovirus-induced T cell responses accelerate Alzheimer’s disease progression in mice. Brain awag043. (10.1093/brain/awag043)
• Lauder, S. N. et al. 2026. Optimising anti-PI3Kd and anti-LAG-3 immunotherapy dosing regimens in a mouse model of triple negative breast cancer improves outcome by removing treatment-related adverse events. Journal for ImmunoTherapy of Cancer 14 (2) e012157. (10.1136/jitc-2025-012157)

2025

• McGee, K. et al., 2025. Valaciclovir therapy for secondary suppression of immune response to herpesviruses: An exploratory study. PLOS Pathogens 21 e1013803. (10.1371/journal.ppat.1013803)

2024

• Hopkins, G. et al., 2024. Lower humoral and cellular immunity following asymptomatic SARS-CoV-2 infection compared to symptomatic infection in education (the ACE cohort). Journal of Clinical Immunology 44 (6) 147. (10.1007/s10875-024-01739-0)
• Hulin-Curtis, S. et al., 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43 (6) 114259. (10.1016/j.celrep.2024.114259)

2023

• Whiteside, S. K. et al., 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8 (90) eabo5558. (10.1126/sciimmunol.abo5558)

2022

• Milutinovic, S. et al. 2022. Three-dimensional imaging reveals immune-driven tumor-associated high endothelial venules as a key correlate of tumor rejection following depletion of regulatory T cells. Cancer Research Communications 2 (12), pp.1641-1656. (10.1158/2767-9764.CRC-21-0123)
• Lauder, S. N. et al. 2022. Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion. British Journal of Cancer 127 , pp.1595–1602. (10.1038/s41416-022-01917-0)
• Scurr, M. J. et al. 2022. Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity. Nature Communications 13 5422. (10.1038/s41467-022-32985-8)

2021

• Lauder, S. N. , Vanhaesebroeck, B. and Gallimore, A. 2021. Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach. British Journal of Cancer 125 , pp.467-469. (10.1038/s41416-021-01285-1)
• Lauder, S. N. et al. 2021. Using methylcholanthrene-induced fibrosarcomas to study tumor immunology. In: Methods in Cell Biology. Vol. 163, Elsevier. , pp.59-75. (10.1016/bs.mcb.2020.09.007)

2020

• Pires, A. et al. 2020. Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunology Research 8 (12), pp.1520 - 1531. (10.1158/2326-6066.CIR-20-0070)
• Hughes, E. et al. 2020. Primary breast tumours but not lung metastases induce protective anti-tumour immune responses after Treg-depletion. Cancer Immunology, Immunotherapy 69 , pp.2063 - 2073. (10.1007/s00262-020-02603-x)
• Lauder, S. N. et al. 2020. Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3. Journal for ImmunoTherapy of Cancer 8 (2) e000693. (10.1136/jitc-2020-000693)
• Greenshields-Watson, A. et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32 (2) 107885. (10.1016/j.celrep.2020.107885)

2019

• Thomson, A. et al. 2019. The Ussing chamber system for measuring intestinal permeability in health and disease. BMC Gastroenterology 19 98. (10.1186/s12876-019-1002-4)
• Allen-Redpath, K. et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116 (16), pp.8038-8047. (10.1073/pnas.1814409116)

2018

• Slatter, D. A. et al. 2018. Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies. JCI Insight 3 (6) e98459. (10.1172/jci.insight.98459)

2017

• Zhao, J. et al., 2017. Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 57 (6)(10.1165/rcmb.2017-0031OC)
• Lauder, S. N. et al. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10 (507) eaan2787. (10.1126/scisignal.aan2787)
• Aldrovandi, M. et al. 2017. DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression. Redox Biology 11 , pp.663-672. (10.1016/j.redox.2017.01.001)
• Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2 (1)(10.12688/wellcomeopenres.10308.1)

2016

• Hinz, C. et al. 2016. Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil activating eicosanoid. Journal of Biological Chemistry 291 (26), pp.13448-13464. (10.1074/jbc.M115.700609)

2015

• Ondondo, B. et al., 2015. A distinct chemokine axis does not account for enrichment of Foxp3+ CD4+T cells in carcinogen-induced fibrosarcomas. Immunology 145 (1), pp.94-104. (10.1111/imm.12430)

2013

• Lauder, S. N. et al. 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43 (10), pp.2613-2625. (10.1002/eji.201243018)

2012

• Hammond, V. J. et al. 2012. Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ. Journal of Biological Chemistry 287 (50), pp.41651-41666. (10.1074/jbc.M112.405407)
• Hindley, J. P. et al. 2012. T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T cell depletion. Cancer Research 72 (21), pp.5473-5482. (10.1158/0008-5472.CAN-12-1912)

2011

• Clement, M. et al. 2011. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. The Journal of Immunology 187 (2), pp.654-663. (10.4049/jimmunol.1003941)
• Lauder, S. N. et al. 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66 (5), pp.368-374. (10.1136/thx.2010.150318)
• Hindley, J. P. et al. 2011. Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Research 71 (3), pp.736-746. (10.1158/0008-5472.CAN-10-1797)

2010

• Lauder, S. N. et al. 2010. A critical role for interleukin-6 in limiting influenza-induced pathology and generating heterosubtypic immunity [Abstract]. Immunology 131 (S1), pp.186. (10.1111/j.1365-2567.2010.03390.x)
• Page, C. E. et al., 2010. Interferon-gamma inhibits interleukin-1 beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis. Arthritis Research and Therapy 12 (2) R49. (10.1186/ar2960)

2009

• Gallagher, K. M. E. et al. 2009. Type I interferon (IFNα) acts directly on human memory CD4+ T cells altering their response to antigen. The Journal of Immunology 183 (5), pp.2915-2920. (10.4049/jimmunol.0801607)

2008

• Longhi, M. P. et al., 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) e1000006. (10.1371/journal.ppat.1000006)
• Page, C. E. et al., 2008. Ifn gamma protects articular cartilage against IL-1 induced tissue injury in arthritis. C Page, S Smale, S Lauder, S Carty, R Goodfellow, S Jones, N Topley & A Williams. School of medicine, Cardiff University, Cardiff, CF14 4XN [Poster Abstract]. Rhuematology 47 (s2), pp.II177-II177. (10.1093/rheumatology/kem534)

2007

• Bondeson, J. et al. 2007. Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent. The Journal of Rheumatology 34 (3), pp.523-533.
• Carty, S. M. et al. 2007. Combination therapy with etanercept and sgp130 for rheumatoid arthritis is more effective than monotherapy [Abstract]. Rheumatology 46 (s1), pp.I18-I18. (10.1093/rheumatology/kem1007)
• Lauder, S. N. 2007. Investigating the role of NF-kappaB in the pathology of osteoarthritis. PhD Thesis , Cardiff University.
• Page, C. E. et al., 2007. Interferon gamma decreases interleukin 1 beta-mediated cartilage loss in rheumatoid arthritis [Abstract]. Rheumatology 46 , pp.I45-I46.

2006

• Bondeson, J. et al. 2006. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Research and Therapy 8 (6), pp.187-199. (10.1186/ar2099)
• Amos, N. et al. 2006. Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent. Rheumatology 45 (10), pp.1201-1209. (10.1093/rheumatology/kel078)