![Andrew Lawrence Msc Sussex, PhD Cantab](https://profiles-cardiff.imgix.net/attachments/3020?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Professor Andrew Lawrence
Msc Sussex, PhD Cantab
- Available for postgraduate supervision
Teams and roles for Andrew Lawrence
Professor
Biomedical & Life Sciences
Honorary Visiting Professor
Overview
I am Dean of Research and Innovation for the College of Biomedical and Life Sciences and Professor of Cognitive Neuroscience in the School of Psychology, Cardiff University. I am also Theme lead for 'Healthy Aging' as part of the Cardiff University/Office for National Statistics (ONS) Strategic Partnership
My research focuses on understanding the role of large-scale networks linking the prefrontal cortex and the limbic system in coordinating and regulating higher-level cognitive-emotional processes, with an emphasis on how inter-individual differences in these circuits confer resilience or vulnerability to psychopathology and late life cognitive decline. I use state-of-the-art scanning facilities at the Cardiff University Brain Research Imaging Centre (CUBRIC) to investigate the functional and structural connectivity that coordinates cortical-limbic interactions.
With Professor Kim Graham, Dr Jiaxiang Zhang, Professor Derek Jones and colleagues and funded by the MRC and the Waterloo Foundation, we are collaborating with the Bristol-based Avon Longitudinal Study of Parents and Children to investigate how genes and early environment are linked with the structure and function of the developing and adult fronto-limbic connectome. With Dr Carl Hodgetts, Prof. Kim Graham, Dr Jiaxiang Zhang and Professor John Aggleton, and funded by the BBSRC, we are using naturalistic stimuli combined with ultra-high field (7T) multi-modal imaging to investigate the role of hippocampal-prefrontal interactions in event cognition and autobiographical memory. In other projects, with Dr Matthias Gruber, I am investigating the role of medial temporal lobe – prefrontal connectivity in the link between motivation and memory, especially forms of curiosity; and with Dr Raluca Petrican, I am investigating how large-scale neurocognitive network interactions mediate adaptive and maladaptive responses relevant to psychopathology.
Publication
2025
- Lucie-Read, M. et al., 2025. Multimodal MEG and microstructure-MRI investigations of the human hippocampal scene network.. The Journal of Neuroscience e1700242025. (10.1523/JNEUROSCI.1700-24.2025)
- McNabb, C. B. et al. 2025. WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis. Scientific Data 12 220. (10.1038/s41597-024-04154-7)
2024
- Read, M. et al. 2024. Scene-selectivity in CA1/subicular complex: Multivoxel pattern analysis at 7T. Neuropsychologia 194 108783. (10.1016/j.neuropsychologia.2023.108783)
2023
- Read, M. et al. 2023. A role for the Fornix in temporal sequence memory. European Journal of Neuroscience 57 (7), pp.1141-1160. (10.1111/ejn.15940)
2022
- Berry, S. C. et al. 2022. Subiculum – BNST structural connectivity in humans and macaques. NeuroImage 253 119096. (10.1016/j.neuroimage.2022.119096)
- Karahan, E. et al. 2022. The interindividual variability of multimodal brain connectivity maintains spatial heterogeneity and relates to tissue microstructure. Communications Biology 5 1007. (10.1038/s42003-022-03974-w)
- Lissaman, R. et al. 2022. Tract-specific differences in white matter microstructure between young adult APOE ε4 carriers and non-carriers: A replication and extension study. NeuroImage 2 (4) 100126. (10.1016/j.ynirp.2022.100126)
- Wiseman, C. et al. 2022. Study development and protocol for a cohort study examining the impact of baseline social cognition on response to treatment for people living with post-traumatic stress disorder. European Journal of Psychotraumatology 13 (1) 2093036. (10.1080/20008198.2022.2093036)
2021
- Berry, S. C. et al. 2021. Extended-amygdala intrinsic functional connectivity networks: a population study. Human Brain Mapping 42 (6), pp.1594-1616. (10.1002/hbm.25314)
- Costigan, A. G. et al. 2021. Evidence against altered excitatory/inhibitory balance in the posteromedial cortex of young adult APOE E4 carriers: a resting state 1H-MRS study. Neuroimage: Reports 1 (4) 100059. (10.1016/j.ynirp.2021.100059)
- Petrican, R. , Graham, K. S. and Lawrence, A. D. 2021. Brain-environment alignment during movie watching predicts fluid intelligence and affective function in adulthood. NeuroImage 238 118177. (10.1016/j.neuroimage.2021.118177)
- Petrican, R. et al. 2021. Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology. Developmental Cognitive Neuroscience 52 101032. (10.1016/j.dcn.2021.101032)
2020
- Coad, B. et al. 2020. Structural connections support emotional connections: uncinate fasciculus microstructure is related to the ability to decode facial emotion expressions. Neuropsychologia 145 (10.1016/j.neuropsychologia.2017.11.006)
- Crawford, B. et al. 2020. Brain structure correlates of expected social threat and reward. Scientific Reports 10 18010. (10.1038/s41598-020-74334-z)
- Crawford, B. et al. 2020. Individual differences in social reward and threat expectancies linked to grey matter volumes in key regions of the social brain. [Online].bioRxiv. (10.1101/2020.02.03.916999)Available at: https://doi.org/10.1101/2020.02.03.916999.
- Hodgetts, C. J. et al. 2020. The role of the fornix in human navigational learning. Cortex 124 , pp.97-110. (10.1016/j.cortex.2019.10.017)
- Lord, S. R. et al., 2020. Freezing of gait in people with Parkinson's disease: nature, occurrence, and risk factors. Journal of Parkinson's Disease 10 (2), pp.631-640. (10.3233/JPD-191813)
- Tzavella, L. et al. 2020. The affective priming paradigm as an indirect measure of food attitudes and related choice behaviour. Psychonomic Bulletin and Review 27 , pp.1397-1415. (10.3758/s13423-020-01764-1)
- Williams, A. N. et al. 2020. The role of the pre-commissural fornix in episodic autobiographical memory and simulation. Neuropsychologia 142 Volume 142, May 2020, 107457. (10.1016/j.neuropsychologia.2020.107457)
2019
- Costigan, A. G. et al. 2019. Neurochemical correlates of scene processing in the precuneus/posterior cingulate cortex: A multimodal fMRI and 1H-MRS study. Human Brain Mapping 40 (10), pp.2884-2898. (10.1002/hbm.24566)
- Hodgetts, C. J. et al. 2019. Increased posterior default mode network activity and structural connectivity in young adult APOE-ε4 carriers: a multi-modal imaging investigation. Neurobiology of Aging 73 , pp.82-91. (10.1016/j.neurobiolaging.2018.08.026)
- Karahan, E. et al. 2019. Cognitive and white-matter compartment models reveal selective relations 1 between corticospinal tract microstructure and simple reaction time. Journal of Neuroscience 39 (30), pp.5910-5921. (10.1523/JNEUROSCI.2954-18.2019)
- Valji, A. et al., 2019. Curious connections: white matter pathways supporting individual differences in epistemic and perceptual curiosity. [Online].bioRxiv. (10.1101/642165)Available at: https://doi.org/10.1101/642165.
- Whone, A. et al., 2019. Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease. Brain 142 (3), pp.512-525. (10.1093/brain/awz023)
- Whone, A. L. et al., 2019. Extended treatment with glial cell line-derived neurotrophic factor in Parkinson's Disease. Journal of Parkinson's Disease 9 (2), pp.301-313. (10.3233/JPD-191576)
2017
- Hodgetts, C. J. et al. 2017. Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory. Cortex 94 , pp.1-14. (10.1016/j.cortex.2017.05.010)
- Hodgetts, C. J. et al. 2017. Ultra-high-field fMRI reveals a role for the subiculum in scene perceptual discrimination. Journal of Neuroscience 37 (12), pp.3150-3159. (10.1523/JNEUROSCI.3225-16.2017)
- Ihssen, N. et al., 2017. Neurofeedback of visual food cue reactivity: a potential avenue to alter incentive sensitization and craving. Brain Imaging and Behavior 11 (3), pp.915-924. (10.1007/s11682-016-9558-x)
2016
- Henderson, E. J. et al., 2016. Rivastigmine for gait stability in patients with Parkinson's disease (ReSPonD): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurology 15 (3), pp.249-258. (10.1016/S1474-4422(15)00389-0)
- Hodgetts, C. J. et al. 2016. Evidencing a place for the hippocampus within the core scene processing network. Human Brain Mapping 37 (11), pp.3779-3794. (10.1002/hbm.23275)
- Keedwell, P. A. et al., 2016. Subgenual cingulum microstructure supports control of emotional conflict. Cerebral Cortex 26 (6), pp.2850-2862. (10.1093/cercor/bhw030)
2015
- Hodgetts, C. J. et al. 2015. Dissociable roles of the inferior longitudinal fasciculus and fornix in face and place perception. eLife 4 e07902. (10.7554/eLife.07902)
- Loane, C. et al., 2015. Psychogenic and neural visual-cue response in PD dopamine dysregulation syndrome. Parkinsonism & Related Disorders 21 (11), pp.1336-1341. (10.1016/j.parkreldis.2015.09.042)
- Muhlert, N. and Lawrence, A. D. 2015. Brain structure correlates of emotion-based rash impulsivity. NeuroImage 115 , pp.138-146. (10.1016/j.neuroimage.2015.04.061)
- Pellicano, C. et al., 2015. Morphometric changes in the reward system of Parkinson's disease patients with impulse control disorders. Journal of Neurology 262 (12), pp.2653-2661. (10.1007/s00415-015-7892-3)
- Shine, J. P. et al. 2015. APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults. Scientific Reports 5 16322. (10.1038/srep16322)
- Wu, K. et al., 2015. Single versus multiple impulse control disorders in Parkinson's disease: an 11C-raclopride positron emission tomography study of reward cue-evoked striatal dopamine release. Journal of Neurology 262 (6), pp.1504-1514. (10.1007/s00415-015-7722-7)
2014
- Djamshidian, A. et al., 2014. Perceptual decision-making in patients with Parkinson's disease. Journal of Psychopharmacology 28 (12), pp.1149-1154. (10.1177/0269881114548437)
- Lawrence, A. D. and Brooks, D. J. 2014. Ventral striatal dopamine synthesis capacity is associated with individual differences in behavioral disinhibition. Frontiers in Behavioral Neuroscience 8 86. (10.3389/fnbeh.2014.00086)
- Postans, M. et al. 2014. Individual variation in fornix microstructure and macrostructure is related to visual discrimination accuracy for scenes but not faces. Journal of Neuroscience 34 (36), pp.12121-12126. (10.1523/JNEUROSCI.0026-14.2014)
- van der Klaauw, A. A. et al., 2014. Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues. Journal of Clinical Endocrinology & Metabolism 99 (10) E2101. (10.1210/jc.2014-1651)
- Wu, K. et al., 2014. Problematic internet use in Parkinson's disease. Parkinsonism & Related Disorders 20 (5), pp.482-487. (10.1016/j.parkreldis.2014.01.019)
2013
- Henderson, E. J. et al., 2013. The ReSPonD trial - rivastigmine to stabilise gait in Parkinson's disease a phase II, randomised, double blind, placebo controlled trial to evaluate the effect of rivastigmine on gait in patients with Parkinson's disease who have fallen. BMC Neurology 13 (1) 188. (10.1186/1471-2377-13-188)
- Lawrence, A. D. , Brooks, D. J. and Whone, A. L. 2013. Ventral striatal dopamine synthesis capacity predicts financial extravagance in Parkinson's Disease. Frontiers in Psychology 4 90. (10.3389/fpsyg.2013.00090)
- Peers, P. V. , Simons, J. S. and Lawrence, A. D. 2013. Prefrontal control of attention to threat. Frontiers in Human Neuroscience 7 24. (10.3389/fnhum.2013.00024)
- Politis, M. et al., 2013. Neural response to visual sexual cues in dopamine treatment-linked hypersexuality in Parkinson's disease. Brain 136 (2), pp.400-411. (10.1093/brain/aws326)
2012
- Ghosh, B. C. P. et al., 2012. Social cognitive deficits and their neural correlates in progressive supranuclear palsy. Brain 135 (7), pp.2089-2102. (10.1093/brain/aws128)
- Lawrence, A. D. 2012. Affective neuroscience: Food 'wanting' hotspot in dorsal striatum. Current Biology 22 (20), pp.R878-R880. (10.1016/j.cub.2012.08.031)
- Lawrence, N. S. et al. 2012. Nucleus accumbens response to food cues predicts subsequent snack consumption in women and increased body mass index in those with reduced self-control. Neuroimage 63 (1), pp.415-422. (10.1016/j.neuroimage.2012.06.070)
- Smith, J. E. et al., 2012. Storm in a coffee cup: caffeine modifies brain activation to social signals of threat. Social Cognitive and Affective Neuroscience 7 (7), pp.831-840. (10.1093/scan/nsr058)
2011
- Boy, F. et al. 2011. Dorsolateral Prefrontal γ-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity. Biological Psychiatry 70 (9), pp.866-872. (10.1016/j.biopsych.2011.05.030)
- Lawrence, A. D. , Goerendt, I. K. and Brooks, D. J. 2011. Apathy blunts neural response to money in Parkinson's disease. Social Neuroscience 6 (5-6), pp.653-662. (10.1080/17470919.2011.556821)
- O'Sullivan, S. S. et al., 2011. Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours. Brain 134 (4), pp.969-978. (10.1093/brain/awr003)
2010
- Calder, A. J. et al., 2010. The relation between anger and different forms of disgust: Implications for emotion recognition impairments in Huntington's disease. Neuropsychologia 48 (9), pp.2719-2729. (10.1016/j.neuropsychologia.2010.05.019)
- Dunn, B. D. et al., 2010. Listening to your heart: How interoception shapes emotion experience and intuitive decision making. Psychological Science 21 (12), pp.1835-1844. (10.1177/0956797610389191)
- Evans, A. H. et al., 2010. Compulsive use of dopaminergic drug therapy in Parkinson's disease: Reward and anti-reward. Movement Disorders 25 (7), pp.867-876. (10.1002/mds.22898)
- O'Sullivan, S. S. et al., 2010. Sleep disturbance and impulsive-compulsive behaviours in Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry 82 (6), pp.620-622. (10.1136/jnnp.2009.186874)
- O'Sullivan, S. S. et al., 2010. Impulsive-compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy. Movement Disorders 25 (5), pp.638-642. (10.1002/mds.22902)
- O'Sullivan, S. S. et al., 2010. Excessive hoarding in Parkinson's disease. Movement Disorders 25 (8), pp.1026-1033. (10.1002/mds.23016)
- O'Sullivan, S. S. et al., 2010. Reckless generosity in Parkinson's disease. Movement Disorders 25 (2), pp.221-223. (10.1002/mds.22687)
- Tapper, K. , Pothos, E. M. and Lawrence, A. D. 2010. Feast your eyes: Hunger and trait reward drive predict attentional bias for food cues. Emotion 10 (6), pp.949-954. (10.1037/a0020305)
- Tavares, P. , Barnard, P. J. and Lawrence, A. D. 2010. Emotional complexity and the neural representation of emotion in motion. Social Cognitive and Affective Neuroscience 6 (1), pp.98-108. (10.1093/scan/nsq021)
2009
- Dunn, B. D. et al., 2009. A reduction in positive self-judgment bias is uniquely related to the anhedonic symptoms of depression. Behaviour Research and Therapy 47 (5), pp.374-381. (10.1016/j.brat.2009.01.016)
- Evans, A. H. , Lawrence, A. D. and Lees, A. J. 2009. Changes in psychomotor effects of L-dopa and methylphenidate after sustained dopaminergic therapy in Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry 80 (3), pp.267-272. (10.1136/jnnp.2006.108993)
- Ewbank, M. P. et al., 2009. Anxiety predicts a differential neural response to attended and unattended facial signals of anger and fear. NeuroImage 44 (3), pp.1144-1151. (10.1016/j.neuroimage.2008.09.056)
- Koepp, M. et al., 2009. Evidence for endogenous opioid release in the amygdala during positive emotion. NeuroImage 44 (1), pp.252-256. (10.1016/j.neuroimage.2008.08.032)
- Lawrence, A. D. 2009. Apathy. In: Sander, D. and Scherer, K. eds. Oxford Companion to Emotion and the Affective Sciences. Series in Affective Science Oxford: Oxford University Press. , pp.44.
- Lim, S. et al., 2009. Dopamine dysregulation syndrome, impulse control disorders and punding after deep brain stimulation surgery for Parkinson's disease. Journal of Clinical Neuroscience 16 (9), pp.1148-1152. (10.1016/j.jocn.2008.12.010)
- Peers, P. V. and Lawrence, A. D. 2009. Attentional control of emotional distraction in rapid serial visual presentation. Emotion 9 (1), pp.140-145. (10.1037/a0014507)
- Von Dem Hagen, E. et al. 2009. Leaving a bad taste in your mouth but not in my insula. Social Cognitive and Affective Neuroscience 4 (4), pp.379-386. (10.1093/scan/nsp018)
2008
- Beaver, J. D. et al., 2008. Appetitive motivation predicts the neural response to facial signals of aggression. Journal of Neuroscience 28 (11), pp.2719-2725. (10.1523/JNEUROSCI.0033-08.2008)
- Tavares, P. , Lawrence, A. D. and Barnard, P. J. 2008. Paying attention to social meaning: An fMRI study. Cerebral Cortex 18 (8), pp.1876-1885. (10.1093/cercor/bhm212)
2007
- Bishop, S. J. , Jenkins, R. and Lawrence, A. D. 2007. Neural Processing of Fearful Faces: Effects of Anxiety are Gated by Perceptual Capacity Limitations. Cerebral Cortex 17 (7), pp.1595-1603. (10.1093/cercor/bhl070)
- Calder, A. J. et al., 2007. Disgust sensitivity predicts the insula and pallidal response to pictures of disgusting foods. European Journal of Neuroscience 25 (11), pp.3422-3428. (10.1111/j.1460-9568.2007.05604.x)
- Dunn, B. D. et al., 2007. The accuracy of self-monitoring and its relationship to self-focused attention in dysphoria and clinical depression. Journal of Abnormal Psychology 116 (1), pp.1-15. (10.1037/0021-843X.116.1.1)
- Dunn, B. D. et al., 2007. Heartbeat perception in depression. Behaviour Research and Therapy 45 (8), pp.1921-1930. (10.1016/j.brat.2006.09.008)
- Lawrence, A. D. , Goerendt, I. K. and Brooks, D. J. 2007. Impaired recognition of facial expressions of anger in Parkinson's disease patients acutely withdrawn from dopamine replacement therapy. Neuropsychologia 45 (1), pp.65-74. (10.1016/j.neuropsychologia.2006.04.016)
2006
- Beaver, J. D. et al., 2006. Individual differences in reward drive predict neural responses to images of food. Journal of Neuroscience 26 (19), pp.5160-5166. (10.1523/JNEUROSCI.0350-06.2006)
- Dunn, B. D. , Dalgleish, T. and Lawrence, A. D. 2006. The somatic marker hypothesis: a critical evaluation. Neuroscience & Biobehavioral Reviews 30 (2), pp.239-271. (10.1016/j.neubiorev.2005.07.001)
- Evans, A. H. et al., 2006. Compulsive drug use linked to sensitized ventral striatal dopamine transmission. Annals of Neurology 59 (5), pp.852-858. (10.1002/ana.20822)
- Goerendt, I. K. et al., 2006. Distributed neural actions of anti-parkinsonian therapies as revealed by PET. Journal of Neural Transmission 113 (1), pp.75-86. (10.1007/s00702-005-0305-5)
2005
- Cools, R. et al., 2005. Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces. Psychopharmacology 180 (4), pp.670-679. (10.1007/s00213-005-2215-5)
- Evans, A. H. et al., 2005. Factors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease. Neurology 65 (10), pp.1570-1574. (10.1212/01.wnl.0000184487.72289.f0)
- Evans, A. H. et al., 2005. Relationship between impulsive sensation seeking traits, smoking, alcohol and caffeine intake, and Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry 77 (3), pp.317-321. (10.1136/jnnp.2005.065417)
2004
- Bishop, S. J. , Duncan, J. and Lawrence, A. D. 2004. State anxiety modulation of the amygdala response to unattended threat-related stimuli. The Journal of Neuroscience 24 (46), pp.10364-10368. (10.1523/JNEUROSCI.2550-04.2004)
- Bishop, S. et al., 2004. Prefrontal cortical function and anxiety: exterting control over threat-related stimuli. Nature Neuroscience 7 (2), pp.184-188. (10.1038/nn1173)
- Calder, A. J. et al., 2004. Impaired recognition of anger following damage to the ventral striatum. Brain 127 (9), pp.1958-1969. (10.1093/brain/awh214)
- Dunn, B. D. et al., 2004. Categorical and dimensional reports of experienced affect to emotion-inducing pictures in depression. Journal of Abnormal Psychology 113 (4), pp.654-660. (10.1037/0021-843X.113.4.654)
- Evans, A. H. et al., 2004. Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome. Movement Disorders 19 (4), pp.397-405. (10.1002/mds.20045)
- Goerendt, I. K. , Lawrence, A. D. and Brooks, D. J. 2004. Reward processing in health and Parkinson's disease: Neural organization and reorganization. Cerebral Cortex 14 (1), pp.73-80. (10.1093/cercor/bhg105)
- Lawrence, A. D. and Calder, A. J. 2004. Homologizing human emotions. In: Evans, D. and Cruse, P. eds. Emotion, Evolution and Rationality. Oxford: Oxford University Press. , pp.15-47. (10.1093/acprof:oso/9780198528975.003.0002)
- Lawrence, A. D. , Murphy, F. C. and Calder, A. J. 2004. Dissociating fear and disgust: implications for the structure of emotions. In: Yiend, J. ed. Cognition, Emotion and Psychopathology: Theoretical, Empirical, and Clinical Approaches. Cambridge: Cambridge University Press. , pp.149-171. (10.1017/CBO9780511521263.009)
- Mathews, A. , Yiend, J. and Lawrence, A. D. 2004. Individual differences in the modulation of fear-related brain activation by attentional control. Journal of Cognitive Neuroscience 16 (10), pp.1683-1694. (10.1162/0898929042947810)
- McGowan, S. et al., 2004. Presynaptic dopaminergic function in schizophrenia: a Positron Emission Tomographic [18F]Fluorodopa study. Archives of General Psychiatry 61 (2), pp.134-142. (10.1001/archpsyc.61.2.134)
2003
- Goerendt, I. K. et al., 2003. Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study. Brain 126 (2), pp.312-325. (10.1093/brain/awg035)
- Lawrence, A. D. et al. 2003. Impaired visual discrimination learning in anorexia nervosa. Appetite 40 (1), pp.85-89. (10.1016/S0195-6663(02)00138-1)
- Lawrence, A. D. , Evans, A. H. and Lees, A. J. 2003. Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry?. The Lancet Neurology 2 (10), pp.595-604. (10.1016/S1474-4422(03)00529-5)
- Mehta, M. A. et al., 2003. Systemic sulpiride modulates striatal blood flow: relationships to spatial working memory and planning. NeuroImage 20 (4), pp.1982-1994. (10.1016/j.neuroimage.2003.08.007)
- Murphy, F. C. , Nimmo-Smith, I. and Lawrence, A. D. 2003. Functional neuroanatomy of emotions: A meta-analysis. Cognitive, Affective, & Behavioral Neuroscience 3 (3), pp.207-233. (10.3758/CABN.3.3.207)
2002
- Calder, A. J. et al., 2002. Reading the mind from eye gaze. Neuropsychologia 40 (8), pp.1129-1138. (10.1016/S0028-3932(02)00008-8)
- Lawrence, A. D. 2002. Huntington's disease. In: Harrison, J. and Owen, A. M. eds. Cognitive Deficits in Neurological Disorders. London: Dunitz. , pp.169-196.
- Lawrence, A. D. et al. 2002. Selective disruption of the recognition of facial expressions of anger. Neuroreport 13 (6), pp.881-884.
- Rabiner, E. A. et al., 2002. A database of [C-11]WAY-100635 binding to 5-HT1A receptors in normal male volunteers: Normative data and relationship to methodological, demographic, physiological, and behavioral variables. NeuroImage 15 (3), pp.620-632. (10.1006/nimg.2001.0984)
2001
- Cagnin, A. et al., 2001. In vivo visualization of activated glia by [C-11] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. Brain 124 (10), pp.2014-2027. (10.1093/brain/124.10.2014)
- Calder, A. J. , Lawrence, A. D. and Young, A. W. 2001. Neuropsychology of fear and loathing. Nature Reviews Neuroscience 2 , pp.352-363. (10.1028/35072584)
- Lawrence, A. D. and Grasby, P. M. 2001. The functional neuroanatomy of emotional disorders. In: Boller, F. and Grafman, J. eds. Emotional Behaviour and its Disorders. Vol. 5, Handbook of Neuropsychology, 2nd Edition Vol. 5.Amsterdam: Elsevier. , pp.235-262.
- Lawrence, A. D. , Rosser, A. E. and Sahakian, B. J. 2001. Cognition. In: Fawcett, J. W. , Rosser, A. E. and Dunnett, S. B. eds. Brain Damage, Brain Repair. Oxford: Oxford University Press. , pp.243-254. (10.1093/acprof:oso/9780198523376.003.0018)
- Lawrence, A. D. and Sahakian, B. J. 2001. Outcome variables in dementia trials: conceptual and practical issues. In: Guiloff, R. J. ed. Clinical Trials in Neurology. Berlin: Springer-Verlag. , pp.171-182.
2000
- Lawrence, A. D. 2000. Error correction and the basal ganglia: similar computations for action, cognition and emotion?. Trends in Cognitive Sciences 4 (10), pp.365-367. (10.1016/S1364-6613(00)01535-7)
- Lawrence, A. D. et al. 2000. Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits. Brain 123 (7), pp.1349-1364. (10.1093/brain/123.7.1349)
- Watkins, L. H. A. et al., 2000. Impaired planning but intact decision making in early Huntington's disease: implications for specific fronto-striatal pathology. Neuropsychologia 38 (8), pp.1112-1125. (10.1016/S0028-3932(00)00028-2)
1999
- Lawrence, A. D. et al. 1999. Steps to a neurochemistry of personality [Letter]. Behavioral and Brain Sciences 22 (3), pp.528-529. (10.1017/S0140525X99332040)
- Lawrence, A. D. et al. 1999. Discrimination, reversal, and shift learning in Huntington's disease: mechanisms of impaired response selection. Neuropsychologia 37 (12), pp.1359-1374. (10.1016/S0028-3932(99)00035-4)
1998
- Koepp, M. J. et al., 1998. Evidence for striatal dopamine release during a video game [Letter]. Nature 393 (6682), pp.266-268. (10.1038/30498)
- Lawrence, A. D. et al. 1998. Evidence for specific cognitive deficits in preclinical Huntington's disease. Brain 121 (7), pp.1329-1341. (10.1093/brain/121.7.1329)
- Lawrence, A. D. and Sahakian, B. J. 1998. The cognitive psychopharmacology of Alzheimer's disease: Focus on cholinergic systems. Neurochemical Research 23 (5), pp.787-794. (10.1023/A:1022419712453)
- Lawrence, A. D. , Sahakian, B. J. and Robbins, T. W. 1998. Cognitive functions and corticostriatal circuits: insights from Huntington's disease. Trends in Cognitive Sciences 2 (10), pp.379-388. (10.1016/S1364-6613(98)01231-5)
- Lawrence, A. D. et al. 1998. The relationship between striatal dopamine receptor binding and cognitive performance in Huntington's disease. Brain 121 (7), pp.1343-1355. (10.1093/brain/121.7.1343)
- Robbins, T. W. et al., 1998. A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: Implications for theories of executive functioning and cognitive aging. Journal of the International Neuropsychological Society 4 (5), pp.474-490.
1996
- Lawrence, A. D. and Sahakian, B. J. 1996. The neuropsychology of fronto-striatal dementias. In: Woods, R. T. ed. Handbook of the Clinical Psychology of Aging. Chichester: Wiley. , pp.243-265.
- Lawrence, A. D. et al. 1996. Executive and mnemonic functions in early Huntington's disease. Brain 119 (5), pp.1633-1645. (10.1093/brain/119.5.1633)
1995
- Lawrence, A. D. and Sahakian, B. J. 1995. Alzheimer Disease, Attention, and the Cholinergic System. Alzheimer Disease & Associated Disorders 9 (S2), pp.37-49.
Articles
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Book sections
- Lawrence, A. D. 2009. Apathy. In: Sander, D. and Scherer, K. eds. Oxford Companion to Emotion and the Affective Sciences. Series in Affective Science Oxford: Oxford University Press. , pp.44.
- Lawrence, A. D. 2002. Huntington's disease. In: Harrison, J. and Owen, A. M. eds. Cognitive Deficits in Neurological Disorders. London: Dunitz. , pp.169-196.
- Lawrence, A. D. and Calder, A. J. 2004. Homologizing human emotions. In: Evans, D. and Cruse, P. eds. Emotion, Evolution and Rationality. Oxford: Oxford University Press. , pp.15-47. (10.1093/acprof:oso/9780198528975.003.0002)
- Lawrence, A. D. and Grasby, P. M. 2001. The functional neuroanatomy of emotional disorders. In: Boller, F. and Grafman, J. eds. Emotional Behaviour and its Disorders. Vol. 5, Handbook of Neuropsychology, 2nd Edition Vol. 5.Amsterdam: Elsevier. , pp.235-262.
- Lawrence, A. D. , Murphy, F. C. and Calder, A. J. 2004. Dissociating fear and disgust: implications for the structure of emotions. In: Yiend, J. ed. Cognition, Emotion and Psychopathology: Theoretical, Empirical, and Clinical Approaches. Cambridge: Cambridge University Press. , pp.149-171. (10.1017/CBO9780511521263.009)
- Lawrence, A. D. , Rosser, A. E. and Sahakian, B. J. 2001. Cognition. In: Fawcett, J. W. , Rosser, A. E. and Dunnett, S. B. eds. Brain Damage, Brain Repair. Oxford: Oxford University Press. , pp.243-254. (10.1093/acprof:oso/9780198523376.003.0018)
- Lawrence, A. D. and Sahakian, B. J. 2001. Outcome variables in dementia trials: conceptual and practical issues. In: Guiloff, R. J. ed. Clinical Trials in Neurology. Berlin: Springer-Verlag. , pp.171-182.
- Lawrence, A. D. and Sahakian, B. J. 1996. The neuropsychology of fronto-striatal dementias. In: Woods, R. T. ed. Handbook of the Clinical Psychology of Aging. Chichester: Wiley. , pp.243-265.
Websites
- Crawford, B. et al. 2020. Individual differences in social reward and threat expectancies linked to grey matter volumes in key regions of the social brain. [Online].bioRxiv. (10.1101/2020.02.03.916999)Available at: https://doi.org/10.1101/2020.02.03.916999.
- Valji, A. et al., 2019. Curious connections: white matter pathways supporting individual differences in epistemic and perceptual curiosity. [Online].bioRxiv. (10.1101/642165)Available at: https://doi.org/10.1101/642165.
Research
Summary
My research uses converging cognitive neuroscience methods to study the role of large-scale networks linking the prefrontal cortex and the limbic system in coordinating and regulating higher-level cognitive-emotional processes, with an emphasis on how inter-individual differences in the structure and function of these circuits confer resilience or vulnerability to psychopathology and late life cognitive decline.
Currently, my lab, which is run jointly with Professor Kim Graham, is working on the following research projects:
The role of PFC-Amygdala interactions in adaptive socio-affective behaviour
In this line of research, we study how Individual differences in affective and social processes may arise from variability in amygdala-prefrontal (PFC) circuitry and related genetic and environmental heterogeneity. A particular focus has been on investigating the role of white matter tracts, including the uncinate fasciculus, that carry neuronal fibres connecting the PFC with the MTL and other regions of the cortex. We use several cognitive neuroscience methods (structural MRI, diffusion MRI, task-based and task-free functional MRI, MR Spectroscopy and more recently computational modelling) to explore how amygdala-PFC interactions mediate core cognitive-affective processes underpinning the detection/expression/interpretation of socially relevant signals and that guide adaptive social approach and avoidance motivation, particularly in the context of the social- evaluative threats (and rewards) that are anticipation unique to complex human social life.
The role of PFC-hippocampal interactions in autobiographical memory and event cognition
In this line of research, we study how individual differences in autobiographical and event memory (including forms of imagination and deliberation) may arise from variability in hippocampal-prefrontal and related circuitry and related genetic and environmental/cultural heterogeneity. A particular focus has been on investigating the role of white matter tracts, including the fornix and cingulum bundle , that carry neuronal fibres connecting the PFC with the MTL and other regions of the cortex (as part of a wider 'core' or 'default mode' network). We use several cognitive neuroscience methods (structural MRI, diffusion MRI, task-based and task-free functional MRI, eye-tracking, MEG, and MR Spectroscopy) to explore how MTL-PFC interactions mediate core representations and processes underpinning the uniquely human capacity for "mental time travel" or "self-projection" and self-regulation.
Key current funding
2021-2024 BBSRC: The subiculum: a key interface between scene representation and event memory? Lead PIs: Hodgetts and Lawrence. Co-PIs: Aggleton, Zhang, Graham £1.2M
2021-23 The Waterloo Foundation: How does hippocampal maturation support the development of human memory? PI: Graham, Co-PIs: Lawrence, Zhang, Hodgetts, Adlam & Langley £300k
2017-21 MRC: Characterising brain network differences during scene perception and memory in APOE-e4 carriers: multi-modal imaging in ALSPAC. Lead PIs: Graham & Lawrence. Co-PIs Saksida, Jones, Wise, Filippini, Mackay, Kordas £1.75M
Teaching
I am coordinator (and sole lecturer) on the final year module PS3416 "Emotion: social and neuroscience perspectives"
This course aims to provide students with an understanding of social and neuroscience perspectives on emotion, and how they might be integrated. The first half of the course focuses on the social (including cultural) functions of emotions. The second half focuses on the neuroscience of emotion and communication of emotions, including brain imaging (fMRI, EEG) and patient-based neuropsychological approaches to understanding the neural underpinnings of emotions and their intra-individual and social functions. The aim is to provide an integrated overview and understanding of contemporary debates and techniques in affective science and their relevance to 'the real world'
In addition, I give lectures (on the role of large-scale neurocognitive networks in emotion) , workshops (on neuroimaging meta analysis) and journal clubs on the module PST516: Topics in Cognitive Neuroscience as part of the MSc in Neuroimaging methods and applications
I supervise final year and MSc students on their research projects. These are usually on some aspect of the social functions of emotion and mental time travel/self-projection. I am a Personal Tutor to students at all levels of the Undergraduate degree.
Biography
Postgraduate education
1994: MSc Experimental Psychology (University of Sussex)
1997: PhD Experimental Psychology (University of Cambridge). Supervised by TW Robbins & BJ Sahakian
Employment
Mar 2007-present: Professor of Cognitive Neuroscience, School of Psychology, Cardiff University, UK
2004-2007: MRC Programme Leader (track), MRC Cognition and Brain Sciences Unit, Cambridge, UK (Emotion group)
2000-2004: Postdoctoral scientist, MRC Cognition and Brain Sciences Unit, Cambridge, UK
1997-2000: Postdoctoral training fellowship (neuroimaging), MRC Clinical Sciences Centre, London, UK
Honours and awards
Awards
2005-present: Lifetime fellowship, Clare Hall, Cambridge University, UK
Professional memberships
Internation Society for Research on Emotion (ISRE)
Supervisions
I have successfully supervised over a dozen PhD and MD students all of whom have successfully completed their PhD and passed with only minor corrections.
Students wishing to work in the group should be interested in studying the role of large-scale networks linking the prefrontal cortex and the limbic system in coordinating and regulating higher-level cognitive-emotional processes, with a particular focus on autobiographical memory/event cognition and/or adaptive social behaviour, including social emotions, from a functional perspective.
Skills in neuroimaging, (multivariate) statistics and data science are likely to be required, as much of our research involves application of multi-modal imaging approaches to test the functionality of these neural circuits. Our translational work involves research with young and older individuals at varying levels of risk for psychopathology and/or later life cognitive decline, but also cross-cultural investigations with researchers working in low-to-middle income countries (e.g. India). We are also engaging in a new line of work on the development of fronto-limbic circuitry, which involves brain imaging and cognitive phenotyping studies in children. We also have an increasing interest in the application of natural language processing tools in the study of autobiographical memory and emotional language coding.
If you are interested in applying for a PhD, or for further information regarding my postgraduate research, please contact me directly (contact details available on the 'Overview' page), or submit a formal application.
Current PhD students
Aminette D'Souza (jointly with Professor Kim Graham, Cardiff University)
Dr Chantelle Wiseman (jointly with Professor Stan Zammit, Cardiff/Bristol Universities)
Rikki Lissaman (jointly with Dr Carl Hodgetts, RHUL and Professor Kim Graham, Cardiff)
Samuel Berry (jointly with Dr Tom Lancaster, Bath)
Contact Details
[email protected]
+44 29208 70712
Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ
+44 29208 70712
Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, CF24 4HQ