Mrs Sian Llewellyn-Lacey

2025

• Autaa, G. et al. 2025. Ageing and inflammation limit the induction of SARS-CoV-2-specific CD8+ T cell responses in severe COVID-19. JCI Insight 10(4), article number: e180867. (10.1172/jci.insight.180867)
• Berneman, Z. N. et al. 2025. WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome. Journal of Hematology and Oncology 18(1), article number: 9. (10.1186/s13045-025-01661-x)

2024

• White, E. et al. 2024. Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1. Nature Immunology 25(9), pp. 1555–1564. (10.1038/s41590-024-01931-9)
• Dallan, B. et al. 2024. Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19. Nature Aging 4(8), pp. 1121–1136. (10.1038/s43587-024-00644-w)
• Heim, K. et al. 2024. Attenuated effector T cells are linked to control of chronic HBV infection. Nature Immunology 25(9), pp. 1650-1662. (10.1038/s41590-024-01928-4)
• Simpson, J. et al. 2024. Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV. JCI Insight 9(14) (10.1172/jci.insight.174168)
• Cabral-Piccin, M. P. et al. 2024. CD8+ T cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy. AIDS 38(2), pp. 161-166. (10.1097/QAD.0000000000003746)

2023

• Cai, C. et al. 2023. SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19. Science Immunology 8(90) (10.1126/sciimmunol.adh0687)
• Winkler, F. et al. 2023. Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8 + T cells. Gut 72(10), pp. 1971-1984. (10.1136/gutjnl-2022-328734)
• Adamo, S. et al. 2023. Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox. Cell Host & Microbe 31(6), pp. 928-936. (10.1016/j.chom.2023.04.015)
• Fahad, A. S. et al. 2023. Cell activation-based screening of natively paired human T cell receptor repertoires. Scientific Reports 13, article number: 8011. (10.1038/s41598-023-31858-4)
• Cabral-Piccin, M. P. et al. 2023. Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection. EBioMedicine 91, article number: 104557. (10.1016/j.ebiom.2023.104557)
• Shepherd, F. R. et al. 2023. The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells. Communications Biology 6, article number: 78. (10.1038/s42003-023-04420-1)
• Proietto, D. et al. 2023. Ageing curtails the diversity and functionality of nascent CD8 + T cell responses against SARS-CoV-2. Vaccines 11(1), article number: 154. (10.3390/vaccines11010154)

2022

• Fahad, A. S. et al. 2022. Immortalization and functional screening of natively paired human T cell receptor repertoires. Protein Engineering, Design & Selection 35, article number: gzab034. (10.1093/protein/gzab034)
• Nicoli, F. et al. 2022. Altered basal lipid metabolism underlies the functional impairment of naive CD8+ T cells in elderly humans. The Journal of Immunology 208(3), pp. 562–570. (10.4049/jimmunol.2100194)

2021

• Niessl, J. et al. 2021. Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue. Science Immunology 6(64), article number: eabk0894. (10.1126/sciimmunol.abk0894)
• Man, S. et al. 2021. Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells. The Journal of Immunology 207(4), pp. 1009-1017. (10.4049/jimmunol.2000756)
• Clement, M. et al. 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118(29), article number: e2019639118. (10.1073/pnas.2019639118)
• Heim, K. et al. 2021. TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection. Gut 70, pp. 1550-1560. (10.1136/gutjnl-2020-322404)
• Nicoli, F. et al. 2021. Use of a novel peptide welding technology platform for the development of B- and T-Cell epitope-based vaccines. Vaccines 9(5), article number: 526. (10.3390/vaccines9050526)
• Hensel, N. et al. 2021. Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection. Nature Immunology 22(2), pp. 229–239. (10.1038/s41590-020-00817-w)
• Schulien, I. et al. 2021. Characterization of pre-existing and induced SARS-CoV-2-specific CD8+ T cells. Nature Medicine 27(1) (10.1038/s41591-020-01143-2)

2020

• Galletti, G. et al. 2020. Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans. Nature Immunology 21, pp. 1552-1562. (10.1038/s41590-020-0791-5)
• Buggert, M. et al. 2020. The identity of human tissue-emigrant CD8+ T cells. Cell 183(7), pp. 1946-1961. (10.1016/j.cell.2020.11.019)
• Weinfurter, J. T. et al. 2020. Identifying a minor histocompatibility antigen in mauritian cynomolgus macaques encoded by APOBEC3C. Frontiers in Immunology 11, article number: 586251. (10.3389/fimmu.2020.586251)
• Sekine, T. et al. 2020. Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19. Cell 183(1), pp. 158-168. (10.1016/j.cell.2020.08.017)
• Passaes, C. et al. 2020. Optimal maturation of the SIV-Specific CD8+ T cell response after primary infection is associated with natural control of SIV: ANRS SIC study. Cell Reports 32(12), article number: 108174. (10.1016/j.celrep.2020.108174)
• Sekine, T. et al. 2020. TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells. Science Immunology 5(49), article number: eaba7918. (10.1126/sciimmunol.aba7918)
• Pearson, F. E. et al. 2020. Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells. Clinical and Translational Immunology 9 (10.1002/cti2.1141)

2019

• Tauber, C. et al. 2019. Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma. Oncotarget 10(50), pp. 5194-5206. (10.18632/oncotarget.27146)
• Schuch, A. et al. 2019. Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load. Gut 68, pp. 905-915. (10.1136/gutjnl-2018-316641)
• McLaren, J. et al. 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202(3), pp. 943-955. (10.4049/jimmunol.1701757)

2018

• Martin, M. P. et al. 2018. Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. Journal of Clinical Investigation 128(5), pp. 1903. (10.1172/JCI98463)
• Lissina, A. et al. 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8(1), article number: 2534. (10.1038/s41598-017-18062-x)

2017

• Dockree, T. et al. 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95(1), pp. 68-76. (10.1038/icb.2016.85)

2016

• Clement, M. et al. 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6, article number: 35332. (10.1038/srep35332)
• Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94(6), pp. 573-582. (10.1038/icb.2016.12)

2013

• van den Berg, H. A. et al. 2013. Cellular-level versus receptor-level response threshold hierarchies in T-cell activation. Frontiers in Immunology 4, article number: 250. (10.3389/fimmu.2013.00250)
• Eukeruche-Makinde, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
• Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)

2012

• Wooldridge, L. et al. 2012. A single autoimmune T cell receptor recognizes more than a million different peptides. Journal of Biological Chemistry 287(2), pp. 1168-1177. (10.1074/jbc.M111.289488)

2008

• Chong, L. K., Aicheler, R., Llewellyn-Lacey, S., Tomasec, P., Brennan, P. and Wang, E. C. Y. 2008. Proliferation and interleukin 5 production by CD8hiCD57+ T cells. European Journal of Immunology 38(4), pp. 995-1000. (10.1002/eji.200737687)
• Wilkinson, G. W. G. et al. 2008. Modulation of natural killer cells by human cytomegalovirus. Journal of Clinical Virology 41(3), pp. 206-212. (10.1016/j.jcv.2007.10.027)

2005

• Tomasec, P. et al. 2005. Downregulation of natural killer cell-activating ligand CD155 by human cytomegalovirus UL141. Nature Immunology 6(2), pp. 181-188. (10.1038/ni1156)