![Eamon McGreal BSc (Hons), PhD, PgCUTL](https://profiles-cardiff.imgix.net/attachments/5271?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Eamon McGreal
(he/him)
BSc (Hons), PhD, PgCUTL
Senior Lecturer
Overview
I work in the Centre for Medical Education here at Cardiff University School of Medicine. I have held a variety of roles within medical education and am currently Director for Year 3 of the MBBCh. This is the first year of Phase 2 of the undergraduate medicine curriculum where students spend a large proportion of their time learning whilst on placement in clinical environments.
I am a scientist with a research background and a particular interest in the immune system and its involvment in chronic inflammatory disease. Much of my previous research focused on the role of white blood cells (neutrophils and macrophages) in airway diseases such as Cystic Fibrosis. My passion for immunology and its interface with human disease continues in my various roles within the Centre for Medical Education.
I am lead for the Respiratory Medicine Case for our Year 1 students.
In addition to these roles, I undertake a range of teaching and assessment activity across the 5 year MBBCh curriculum and the BSc in Medical Pharmacology.
Publication
2018
- Griffiths, J. S. et al. 2018. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB Journal 32(6), pp. 3385-3397. (10.1096/fj.201701145R)
2017
- Stott, M., van den Berg, C., Forton, J., Monk, P., Morgan, B. P. and McGreal, E. 2017. Post-translational modification of complement anaphylatoxins during chronic neutrophilic inflammation. Molecular Immunology 89, pp. 167., article number: 103. (10.1016/j.molimm.2017.06.141)
2014
- Chakraborty, M. et al. 2014. Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants. PLoS ONE 9(12), article number: e114524. (10.1371/journal.pone.0114524)
- Prince, L. R. et al. 2014. Macrophage phenotype is associated with disease severity in preterm infants with chronic lung dsease. PLoS ONE 9(8), article number: e103059. (10.1371/journal.pone.0103059)
- Van Den Berg, C., Tambourgi, D. V., Clark, H. W., Hoong, S. J., Spiller, O. and McGreal, E. 2014. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor. The Journal of Immunology 192(4), pp. 1787-1795. (10.4049/jimmunol.1301920)
2013
- Kotecha, S., Doull, I. J. M., Davies, P. L., McKenzie, Z., Madsen, J., Clark, H. W. and McGreal, E. P. 2013. Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1832(12), pp. 2391-2400. (10.1016/j.bbadis.2013.10.002)
- Kotecha, S., Davies, P. L., Clark, H. W. and McGreal, E. P. 2013. Increased prevalence of low oligomeric state surfactant protein D with restricted lectin activity in bronchoalveolar lavage fluid from preterm infants. Thorax 68(5), pp. 460-467. (10.1136/thoraxjnl-2012-202729)
- Chakraborty, M., McGreal, E. P., Davies, P. L., Nowell, M. A., Jones, S. A. and Kotecha, S. 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104(3), pp. 161-167. (10.1159/000351015)
2012
- McGreal, E. P., Hearne, K. and Spiller, O. B. 2012. Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth. Immunobiology 217(2), pp. 176-186. (10.1016/j.imbio.2011.07.027)
2011
- Beeton, M. L. et al. 2011. Role of pulmonary infection in the development of chronic lung disease of prematurity. European Respiratory Journal 37(6), pp. 1424-1430. (10.1183/09031936.00037810)
- Duvoix, A., Mackay, R., Henderson, N., McGreal, E. P., Postle, A., Reid, K. and Clark, H. 2011. Physiological concentration of calcium inhibits elastase-induced cleavage of a functional recombinant fragment of surfactant protein D. Immunobiology 216(1-2), pp. 72-79. (10.1016/j.imbio.2010.03.006)
- McGreal, E. P., Chakraborty, M., Winter, V. T., Jones, S. A., Coalson, J. J. and Kotecha, S. 2011. Dynamic expression of IL-6 trans-signalling molecules in the lungs of preterm baboons undergoing mechanical ventilation. Neonatology 100(2), pp. 130-138. (10.1159/000322148)
2010
- Chakraborty, M., McGreal, E. P. and Kotecha, S. 2010. Acute lung injury in preterm newborn infants: mechanisms and management. Paediatric Respiratory Reviews 11(3), pp. 162-170. (10.1016/j.prrv.2010.03.002)
- McGreal, E. P. et al. 2010. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802(7-8), pp. 649-658. (10.1016/j.bbadis.2010.04.005)
2009
- Jones, H. E., Taylor, P. R., McGreal, E. P., Zamze, S. and Wong, S. Y. C. 2009. The contribution of naturally occurring IgM antibodies, IgM cross-reactivity and complement dependency in murine humoral responses to pneumococcal capsular polysaccharides. Vaccine 27(42), pp. 5806-5815. (10.1016/j.vaccine.2009.07.063)
- McGreal, E. P. 2009. Structural basis of pattern recognition by innate immune molecules. In: Kishore, U. ed. Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology Vol. 653. New York: Springer, pp. 139-161.
2006
- McGreal, E. P., Wienke, D., McKenzie, E. J. and Gordon, R. 2006. Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. European Journal of Immunology 36(5), pp. 1074-82. (10.1002/eji.200535685)
- McGreal, E. P. et al. 2006. The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 16(5), pp. 422-30. (10.1093/glycob/cwj077)
2005
- McGreal, E. P., Miller, J. L. and Gordon, S. 2005. Ligand recognition by antigen-presenting cell C-type lectin receptors. Current Opinion in Immunology 17(1), pp. 18-24. (10.1016/j.coi.2004.12.001)
2004
- McGreal, E. P., Martinez-Pomares, L. and Gordon, S. 2004. Divergent roles for C-type lectins expressed by cells of the innate immune system. Molecular Immunology 41(11), pp. 1109-1121. (10.1016/j.molimm.2004.06.013)
2002
- McGreal, E. P., Ikawaki, N., Akatsu, H., Morgan, B. P. and Gasque, P. 2002. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. Journal of Immunology 168, pp. 5222-5232.
- McGreal, E. P. and Gasque, P. 2002. Structure-function studies of the receptors for complement C1q. Biochemical Society Transactions 30(6), pp. 1010-1014. (10.1042/BST0301010)
2001
- McGreal, E. P., Gasque, P. and Dean, Y. D. 2001. Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense. European Journal of Immunology 31(5), pp. 1370-81. (10.1002/1521-4141(200105)31:5<1370::AID-IMMU1370>3.0.CO;2-B)
2000
- Dean, Y., McGreal, E. P., Akatsu, H. and Gasque, P. 2000. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. Journal of Biological Chemistry 275(44), pp. 34382-34392. (10.1074/jbc.M006229200)
- Gasque, P., Dean, Y. D., McGreal, E. P., VanBeek, J. and Morgan, B. P. 2000. Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology 49(1-2), pp. 171-186. (10.1016/S0162-3109(00)80302-1)
Articles
- Griffiths, J. S. et al. 2018. Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB Journal 32(6), pp. 3385-3397. (10.1096/fj.201701145R)
- Stott, M., van den Berg, C., Forton, J., Monk, P., Morgan, B. P. and McGreal, E. 2017. Post-translational modification of complement anaphylatoxins during chronic neutrophilic inflammation. Molecular Immunology 89, pp. 167., article number: 103. (10.1016/j.molimm.2017.06.141)
- Chakraborty, M. et al. 2014. Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants. PLoS ONE 9(12), article number: e114524. (10.1371/journal.pone.0114524)
- Prince, L. R. et al. 2014. Macrophage phenotype is associated with disease severity in preterm infants with chronic lung dsease. PLoS ONE 9(8), article number: e103059. (10.1371/journal.pone.0103059)
- Van Den Berg, C., Tambourgi, D. V., Clark, H. W., Hoong, S. J., Spiller, O. and McGreal, E. 2014. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor. The Journal of Immunology 192(4), pp. 1787-1795. (10.4049/jimmunol.1301920)
- Kotecha, S., Doull, I. J. M., Davies, P. L., McKenzie, Z., Madsen, J., Clark, H. W. and McGreal, E. P. 2013. Functional heterogeneity of pulmonary surfactant protein-D in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1832(12), pp. 2391-2400. (10.1016/j.bbadis.2013.10.002)
- Kotecha, S., Davies, P. L., Clark, H. W. and McGreal, E. P. 2013. Increased prevalence of low oligomeric state surfactant protein D with restricted lectin activity in bronchoalveolar lavage fluid from preterm infants. Thorax 68(5), pp. 460-467. (10.1136/thoraxjnl-2012-202729)
- Chakraborty, M., McGreal, E. P., Davies, P. L., Nowell, M. A., Jones, S. A. and Kotecha, S. 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104(3), pp. 161-167. (10.1159/000351015)
- McGreal, E. P., Hearne, K. and Spiller, O. B. 2012. Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth. Immunobiology 217(2), pp. 176-186. (10.1016/j.imbio.2011.07.027)
- Beeton, M. L. et al. 2011. Role of pulmonary infection in the development of chronic lung disease of prematurity. European Respiratory Journal 37(6), pp. 1424-1430. (10.1183/09031936.00037810)
- Duvoix, A., Mackay, R., Henderson, N., McGreal, E. P., Postle, A., Reid, K. and Clark, H. 2011. Physiological concentration of calcium inhibits elastase-induced cleavage of a functional recombinant fragment of surfactant protein D. Immunobiology 216(1-2), pp. 72-79. (10.1016/j.imbio.2010.03.006)
- McGreal, E. P., Chakraborty, M., Winter, V. T., Jones, S. A., Coalson, J. J. and Kotecha, S. 2011. Dynamic expression of IL-6 trans-signalling molecules in the lungs of preterm baboons undergoing mechanical ventilation. Neonatology 100(2), pp. 130-138. (10.1159/000322148)
- Chakraborty, M., McGreal, E. P. and Kotecha, S. 2010. Acute lung injury in preterm newborn infants: mechanisms and management. Paediatric Respiratory Reviews 11(3), pp. 162-170. (10.1016/j.prrv.2010.03.002)
- McGreal, E. P. et al. 2010. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802(7-8), pp. 649-658. (10.1016/j.bbadis.2010.04.005)
- Jones, H. E., Taylor, P. R., McGreal, E. P., Zamze, S. and Wong, S. Y. C. 2009. The contribution of naturally occurring IgM antibodies, IgM cross-reactivity and complement dependency in murine humoral responses to pneumococcal capsular polysaccharides. Vaccine 27(42), pp. 5806-5815. (10.1016/j.vaccine.2009.07.063)
- McGreal, E. P., Wienke, D., McKenzie, E. J. and Gordon, R. 2006. Carbohydrate-independent recognition of collagens by the macrophage mannose receptor. European Journal of Immunology 36(5), pp. 1074-82. (10.1002/eji.200535685)
- McGreal, E. P. et al. 2006. The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 16(5), pp. 422-30. (10.1093/glycob/cwj077)
- McGreal, E. P., Miller, J. L. and Gordon, S. 2005. Ligand recognition by antigen-presenting cell C-type lectin receptors. Current Opinion in Immunology 17(1), pp. 18-24. (10.1016/j.coi.2004.12.001)
- McGreal, E. P., Martinez-Pomares, L. and Gordon, S. 2004. Divergent roles for C-type lectins expressed by cells of the innate immune system. Molecular Immunology 41(11), pp. 1109-1121. (10.1016/j.molimm.2004.06.013)
- McGreal, E. P., Ikawaki, N., Akatsu, H., Morgan, B. P. and Gasque, P. 2002. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. Journal of Immunology 168, pp. 5222-5232.
- McGreal, E. P. and Gasque, P. 2002. Structure-function studies of the receptors for complement C1q. Biochemical Society Transactions 30(6), pp. 1010-1014. (10.1042/BST0301010)
- McGreal, E. P., Gasque, P. and Dean, Y. D. 2001. Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense. European Journal of Immunology 31(5), pp. 1370-81. (10.1002/1521-4141(200105)31:5<1370::AID-IMMU1370>3.0.CO;2-B)
- Dean, Y., McGreal, E. P., Akatsu, H. and Gasque, P. 2000. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. Journal of Biological Chemistry 275(44), pp. 34382-34392. (10.1074/jbc.M006229200)
- Gasque, P., Dean, Y. D., McGreal, E. P., VanBeek, J. and Morgan, B. P. 2000. Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology 49(1-2), pp. 171-186. (10.1016/S0162-3109(00)80302-1)
Book sections
- McGreal, E. P. 2009. Structural basis of pattern recognition by innate immune molecules. In: Kishore, U. ed. Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology Vol. 653. New York: Springer, pp. 139-161.
Biography
2023-Present: Director Year 3, Centre for Medical Education, Cardiff University School of Medicine.
2016-2023: Deputy Director Year 3, Deputy Director SSCs, Centre for Medical Education, Cardiff University School of Medicine.
Oct 2005-2016: Lecturer in Paediatric Respiratory Biology, Cardiff University School of Medicine.
2008: Fellow of the Higher Education Academy.
2008: Postgraduate Certificate in University Teaching and Learning, Cardiff University.
Jan 2005-Oct 2005: Wellcome Trust Value in People Award Postdoctoral Research Fellow, Dept. Medical Biochemistry & Immunology, Cardiff University School of Medicine.
April 2002- December 2004: Postdoctoral Researcher, Sir William Dunn School of Pathology, University of Oxford.
1998-2002: PhD studentship, Dept. Medical Biochemistry, University of Wales College of Medicine, Cardiff.
1998-1999: Diploma in Biomedical Methods, University of Wales College of Medicine, Cardiff.
1993-1997: BSc (Hons) 1st Class, Biochemistry, National University of Ireland, Galway.
Honours and awards
Specialisms
- Cellular immunology
- Innate immunity
- Respiratory diseases
- medical education