![Mari Nowell MSc, PhD](https://profiles-cardiff.imgix.net/attachments/6840?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Mari Nowell
(she/her)
MSc, PhD
Teams and roles for Mari Nowell
Research Development Manager
Research Development
Research Development Manager
Research Development
Overview
I am a Research Development Manager in The Research Service, facing the College of Physical Sciences and Engineering at Cardiff University.
I have broad experience of working in research, from post-doc, to independent and externally-funded research fellow, to College Research Development Manager.
I support people who are developing their ideas for externally funded research grant proposals and I lead on research grant calls with an institutional limit and also EPSRC funding.
In my previous role as Deputy Business Manager for the PVC-RIE, I was involved with setting up University working groups around Research culture, including the DORA working group (Declaration of Research Assessment) and the Research Culture working group, and helped to draft the initial Research Culture action plan.
I am passionate about promoting Equality, Diversity and Inclusion in research practices.
Publication
2014
- Garbers, C. et al., 2014. The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 (9), pp.1485-1494. (10.1016/j.bbadis.2014.05.018)
- Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5 174. (10.3389/fendo.2014.00174)
- Greenhill, C. J. et al., 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16 (4) 419. (10.1186/s13075-014-0419-y)
2013
- Chakraborty, M. et al. 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104 (3), pp.161-167. (10.1159/000351015)
- Greenhill, C. J. et al. 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63 (3), pp.267. (10.1016/j.cyto.2013.06.105)
- Hayes, A. J. et al. 2013. Spinal deformity in aged zebrafish Is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis. PLoS ONE 8 (9), pp.e75787. (10.1371/journal.pone.0075787)
- Jones, G. W. et al. 2013. Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A. Annals of the Rheumatic Diseases 72 (10), pp.1738-1742. (10.1136/annrheumdis-2013-203771)
- Moideen, A. N. et al. 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52 (s1), pp.138-139.
2012
- Bonnet, C. et al. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23 , pp.S527-S527.
- Greenhill, C. et al. 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51 , pp.48-48. (10.1093/rheumatology/kes117)
- Greenhill, C. J. et al. 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137 , pp.43-44.
- Jones, G. W. et al. 2012. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Rhuematology 51 (s3), pp.43-44. (10.1093/rheumatology/kes117)
- Moideen, A. N. et al. 2012. Nicotinamide adenine dinucleotide (NAD plus) biosynthesis enzymes in rheumatoid arthritis [Abstract]. Rhuematology 51 (s3), pp.142-142. (10.1093/rheumatology/kes108)
- Nowell, M. A. , Evans, L. C. and Williams, A. S. 2012. PBEF/NAMPT/visfatin: a promising drug target for treating rheumatoid arthritis?. Future Medicinal Chemistry 4 (6), pp.751-769. (10.4155/fmc.12.34)
2011
- Bonnet, C. S. et al., 2011. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. International Journal of Experimental Pathology 92 (6), pp.A14-A14. (10.1111/j.1365-2613.2011.00780.x)
- Evans, L. C. et al. 2011. Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthritis. Arthritis and Rheumatism 63 (7), pp.1866-1877. (10.1002/art.30338)
- Greenhill, C. J. et al. 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135 (s1), pp.158-158. (10.1111/j.1365-2567.2011.03534.x)
- Jones, G. W. et al. 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Immunology 135 (S1), pp.158. (10.1111/j.1365-2567.2011.03534.x)
- Jones, G. W. et al. 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B- cell responses [Abstract]. Arthritis and Rheumatism 63 (s10), pp.S978-S978. (10.1002/art.33310)
2010
- Leggate, M. et al., 2010. The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones 15 (6), pp.827-833. (10.1007/s12192-010-0192-z)
2009
- Nowell, M. A. et al. 2009. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 182 (1), pp.613-622.
2008
- Caterson, B. et al. 2008. Chondroitin sulphate motifs as biomarkers for the stem/progenitor cell niche in musculoskeletal tissues. European Cells and Materials 16 (Supp 2), pp.47-47.
- Hayes, A. J. et al. 2008. Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. Journal of Histochemistry & Cytochemistry 56 (2), pp.125-38. (10.1369/jhc.7A7320.2007)
- Jones, G. W. et al. 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47 (S2), pp.II20-II20. (10.1093/rheumatology/kem509)
- Jones, S. A. et al. 2008. Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression. Immunology Endocrine & Metabolic Agents in Medicinal Chemistry 8 (3), pp.235-246.
- Longhi, M. P. et al., 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) e1000006. (10.1371/journal.ppat.1000006)
- Nowell, M. A. and Williams, A. S. 2008. Selective inhibition of PBEF activity with a small molecule inhibitor, APO866 ameliorates collagen-induced arthritis [Abstract]. Rheumatology 47 , pp.II58-II59.
2007
- Campinho, M. A. et al., 2007. Troponin T isoform expression is modulated during Atlantic Halibut metamorphosis. BMC Developmental Biology 7 (1) 71. (10.1186/1471-213X-7-71)
- Carty, S. M. et al. 2007. Combination therapy with etanercept and sgp130 for rheumatoid arthritis is more effective than monotherapy [Abstract]. Rheumatology 46 (s1), pp.I18-I18. (10.1093/rheumatology/kem1007)
- Williams, A. S. et al. 2007. Interferon-γ protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints. Arthritis & Rheumatism 56 (7), pp.2244-2254. (10.1002/art.22732)
2006
- Carty, S. M. et al. 2006. TINFa and IL-6/slL-6R interactions regulate the magnitude and the phenotype of synovial Leucocyte infiltration in rheumatoid arthritis [Abstract]. Arthritis and Rheumatism 54 (9), pp.S597-S597.
- Dimitrov, S. et al., 2006. Sleep enhances IL-6 trans-signaling in humans. The FASEB Journal 20 (12), pp.2174-2176. (10.1096/fj.06-5754fje)
- Nowell, M. A. et al. 2006. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Arthritis & Rheumatism 54 (7), pp.2084-2095. (10.1002/art.21942)
- Peake, N. J. et al., 2006. Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor. Rheumatology 45 (12), pp.1485-1489. (10.1093/rheumatology/kel154)
- Richards, P. J. et al., 2006. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis & Rheumatism 54 (5), pp.1662-1672. (10.1002/art.21818)
2005
- Carty, S. M. et al., 2005. Interleukin 6 (IL-6) signalling in rheumatoid arthritis. Rheumatology 44 , pp.I38-I38.
2004
- McLoughlin, R. M. et al. 2004. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. The Journal of Immunology 172 , pp.5676-83.
2003
- Nowell, M. A. et al. 2003. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. The Journal of Immunology 171 (6), pp.3202-3209.
2001
- Coffey, M. J. et al. 2001. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 98 (14), pp.8006-8011. (10.1073/pnas.141136098)
- Power, D. M. et al., 2001. Thyroid hormones in growth and development of fish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 130 (4), pp.447-459. (10.1016/S1532-0456(01)00271-X)
2000
- Nowell, M. A. et al. 2000. Cloning and expression of an elongation factor-1a in sea bream (Sparus aurata) larvae and adult tissue. Marine Biotechnology 2 (2), pp.173-179. (10.1007/s101269900022)
Articles
- Bonnet, C. S. et al., 2011. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. International Journal of Experimental Pathology 92 (6), pp.A14-A14. (10.1111/j.1365-2613.2011.00780.x)
- Bonnet, C. et al. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23 , pp.S527-S527.
- Campinho, M. A. et al., 2007. Troponin T isoform expression is modulated during Atlantic Halibut metamorphosis. BMC Developmental Biology 7 (1) 71. (10.1186/1471-213X-7-71)
- Carty, S. M. et al., 2005. Interleukin 6 (IL-6) signalling in rheumatoid arthritis. Rheumatology 44 , pp.I38-I38.
- Carty, S. M. et al. 2006. TINFa and IL-6/slL-6R interactions regulate the magnitude and the phenotype of synovial Leucocyte infiltration in rheumatoid arthritis [Abstract]. Arthritis and Rheumatism 54 (9), pp.S597-S597.
- Carty, S. M. et al. 2007. Combination therapy with etanercept and sgp130 for rheumatoid arthritis is more effective than monotherapy [Abstract]. Rheumatology 46 (s1), pp.I18-I18. (10.1093/rheumatology/kem1007)
- Caterson, B. et al. 2008. Chondroitin sulphate motifs as biomarkers for the stem/progenitor cell niche in musculoskeletal tissues. European Cells and Materials 16 (Supp 2), pp.47-47.
- Chakraborty, M. et al. 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104 (3), pp.161-167. (10.1159/000351015)
- Coffey, M. J. et al. 2001. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 98 (14), pp.8006-8011. (10.1073/pnas.141136098)
- Dimitrov, S. et al., 2006. Sleep enhances IL-6 trans-signaling in humans. The FASEB Journal 20 (12), pp.2174-2176. (10.1096/fj.06-5754fje)
- Evans, L. C. et al. 2011. Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthritis. Arthritis and Rheumatism 63 (7), pp.1866-1877. (10.1002/art.30338)
- Garbers, C. et al., 2014. The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 (9), pp.1485-1494. (10.1016/j.bbadis.2014.05.018)
- Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5 174. (10.3389/fendo.2014.00174)
- Greenhill, C. et al. 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51 , pp.48-48. (10.1093/rheumatology/kes117)
- Greenhill, C. J. et al. 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137 , pp.43-44.
- Greenhill, C. J. et al. 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63 (3), pp.267. (10.1016/j.cyto.2013.06.105)
- Greenhill, C. J. et al., 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16 (4) 419. (10.1186/s13075-014-0419-y)
- Greenhill, C. J. et al. 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135 (s1), pp.158-158. (10.1111/j.1365-2567.2011.03534.x)
- Hayes, A. J. et al. 2013. Spinal deformity in aged zebrafish Is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis. PLoS ONE 8 (9), pp.e75787. (10.1371/journal.pone.0075787)
- Hayes, A. J. et al. 2008. Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. Journal of Histochemistry & Cytochemistry 56 (2), pp.125-38. (10.1369/jhc.7A7320.2007)
- Jones, G. W. et al. 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Immunology 135 (S1), pp.158. (10.1111/j.1365-2567.2011.03534.x)
- Jones, G. W. et al. 2013. Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A. Annals of the Rheumatic Diseases 72 (10), pp.1738-1742. (10.1136/annrheumdis-2013-203771)
- Jones, G. W. et al. 2012. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Rhuematology 51 (s3), pp.43-44. (10.1093/rheumatology/kes117)
- Jones, G. W. et al. 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47 (S2), pp.II20-II20. (10.1093/rheumatology/kem509)
- Jones, G. W. et al. 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B- cell responses [Abstract]. Arthritis and Rheumatism 63 (s10), pp.S978-S978. (10.1002/art.33310)
- Jones, S. A. et al. 2008. Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression. Immunology Endocrine & Metabolic Agents in Medicinal Chemistry 8 (3), pp.235-246.
- Leggate, M. et al., 2010. The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones 15 (6), pp.827-833. (10.1007/s12192-010-0192-z)
- Longhi, M. P. et al., 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) e1000006. (10.1371/journal.ppat.1000006)
- McLoughlin, R. M. et al. 2004. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. The Journal of Immunology 172 , pp.5676-83.
- Moideen, A. N. et al. 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52 (s1), pp.138-139.
- Moideen, A. N. et al. 2012. Nicotinamide adenine dinucleotide (NAD plus) biosynthesis enzymes in rheumatoid arthritis [Abstract]. Rhuematology 51 (s3), pp.142-142. (10.1093/rheumatology/kes108)
- Nowell, M. A. et al. 2000. Cloning and expression of an elongation factor-1a in sea bream (Sparus aurata) larvae and adult tissue. Marine Biotechnology 2 (2), pp.173-179. (10.1007/s101269900022)
- Nowell, M. A. , Evans, L. C. and Williams, A. S. 2012. PBEF/NAMPT/visfatin: a promising drug target for treating rheumatoid arthritis?. Future Medicinal Chemistry 4 (6), pp.751-769. (10.4155/fmc.12.34)
- Nowell, M. A. et al. 2006. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Arthritis & Rheumatism 54 (7), pp.2084-2095. (10.1002/art.21942)
- Nowell, M. A. et al. 2003. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. The Journal of Immunology 171 (6), pp.3202-3209.
- Nowell, M. A. and Williams, A. S. 2008. Selective inhibition of PBEF activity with a small molecule inhibitor, APO866 ameliorates collagen-induced arthritis [Abstract]. Rheumatology 47 , pp.II58-II59.
- Nowell, M. A. et al. 2009. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 182 (1), pp.613-622.
- Peake, N. J. et al., 2006. Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor. Rheumatology 45 (12), pp.1485-1489. (10.1093/rheumatology/kel154)
- Power, D. M. et al., 2001. Thyroid hormones in growth and development of fish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 130 (4), pp.447-459. (10.1016/S1532-0456(01)00271-X)
- Richards, P. J. et al., 2006. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis & Rheumatism 54 (5), pp.1662-1672. (10.1002/art.21818)
- Williams, A. S. et al. 2007. Interferon-γ protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints. Arthritis & Rheumatism 56 (7), pp.2244-2254. (10.1002/art.22732)
Biography
Research Development Manager (The Research Service) – College PSE facing
Cardiff University / Prifysgol Caerdydd
Sep 2022 - Present
- Research Development Manager for the College of Physical Sciences and Engineering at Cardiff University. Working in Research and Innovation Services
Skills: Research Strategy, Research Development, Funding advice, Grant Support and Grant Advice, Management
Deputy Business Manager (Interim)
Cardiff University / Prifysgol Caerdydd
Jan 2021 - Oct 2022
- Supporting the Pro Vice-Chancellor (PVC) Research, Innovation and Enterprise and their Business Manager / REF Manager to deliver across the remit of the research portfolio, through co-ordination, liaison, advice and strategic business management
Skills: Research Strategy, Business Case Writing, Collaboration, Network-building , Interpersonal skills, Management
Research Development Officer (Research and Innovation Services) – College BLS facing
Cardiff University / Prifysgol Caerdydd
Jul 2014 - Oct 2022
- Working across Cardiff University developing research and project managing strategic University projects.
Skills: Research Development, Funding advice, Grant Support, Fellowship advice and training, Collaboration, Network-building, Management
Ser Cymru Research analyst - Office of the Chief Scientific Advisor for Wales
Llywodraeth Cymru / Welsh Government
Apr 2013 - May 2014
- Advice and scientific expertise to the Welsh Government Science department regarding projects are affiliated with the Sêr Cymru Research Programme.
- Written briefings, reports and updates, engagement with interested parties e.g. Higher Education Funding Council for Wales (HEFCW) and Higher Education Institutions (HEIs)
- Training in Prince2®
Skills: Project Management, Data analysis
Arthritis Research UK Non-Clinical Career Development Fellow - School of Medicine
Cardiff University / Prifysgol Caerdydd
Jan 2007 - Mar 2012
- Competitively won Career Development Fellowship (Arthritis Research UK)
- Carried out research to better understand the mode of action of a novel protein NAMPT (NicotinAMide Phosphoribosyl Transferase), in arthritis, with a view of controlling its activities
- Successfully managed research projects from undergraduate to PhD level
- Taught module for intercalated BSc students
- Published original research articles, review articles and international meeting abstracts.
- Awarded >£450K in external grant funding
- Academic lead for two biotechnology facilities.
Skills: Project/research management, PGR supervision, Research, biochemistry, Molecular Biology, Bioimaging, Data analysis, University teaching