Dr Mari Nowell

2014

• Gilbert, S. J. et al. 2014. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Frontiers in Endocrinology 5, article number: 174. (10.3389/fendo.2014.00174)
• Garbers, C. et al. 2014. The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. Biochimica et Biophysica Acta - Molecular Basis of Disease 1842(9), pp. 1485-1494. (10.1016/j.bbadis.2014.05.018)
• Greenhill, C. J. et al. 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16(4), article number: 419. (10.1186/s13075-014-0419-y)

2013

• Jones, G. W., Greenhill, C. J., Williams, J. O., Nowell, M. A., Williams, A. S., Jenkins, B. J. and Jones, S. A. 2013. Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A. Annals of the Rheumatic Diseases 72(10), pp. 1738-1742. (10.1136/annrheumdis-2013-203771)
• Greenhill, C. J. et al. 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63(3), pp. 267. (10.1016/j.cyto.2013.06.105)
• Hayes, A. J. et al. 2013. Spinal deformity in aged zebrafish Is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis. PLoS ONE 8(9), pp. e75787. (10.1371/journal.pone.0075787)
• Moideen, A. N. et al. 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52(s1), pp. 138-139.
• Chakraborty, M., McGreal, E. P., Davies, P. L., Nowell, M. A., Jones, S. A. and Kotecha, S. 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104(3), pp. 161-167. (10.1159/000351015)

2012

• Greenhill, C. J. et al. 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137, pp. 43-44.
• Bonnet, C., Williams, A. S., Harvey, A., Gilbert, S. J., Moideen, A. N., Nowell, M. A. and Mason, D. J. 2012. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. Osteoporosis International 23, pp. S527-S527.
• Moideen, A. N., Evans, L., Osgood, L. E., Williams, A., Jones, S. A. and Nowell, M. A. 2012. Nicotinamide adenine dinucleotide (NAD plus) biosynthesis enzymes in rheumatoid arthritis [Abstract]. Rhuematology 51(s3), pp. 142-142. (10.1093/rheumatology/kes108)
• Greenhill, C. et al. 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51, pp. 48-48. (10.1093/rheumatology/kes117)
• Jones, G. W., Greenhill, C. J., Williams, A. S., Nowell, M. A., Jenkins, B. J. and Jones, S. A. 2012. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Rhuematology 51(s3), pp. 43-44. (10.1093/rheumatology/kes117)
• Nowell, M. A., Evans, L. C. and Williams, A. S. 2012. PBEF/NAMPT/visfatin: a promising drug target for treating rheumatoid arthritis?. Future Medicinal Chemistry 4(6), pp. 751-769. (10.4155/fmc.12.34)

2011

• Jones, G. W., Greenhill, C. J., Williams, A. S., Nowell, M. A., Jenkins, B. J. and Jones, S. A. 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Immunology 135(S1), pp. 158. (10.1111/j.1365-2567.2011.03534.x)
• Greenhill, C. J. et al. 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135(s1), pp. 158-158. (10.1111/j.1365-2567.2011.03534.x)
• Bonnet, C. S., Williams, A. S., Moideen, A. N., Nowell, M. A. and Mason, D. J. 2011. Intra-articular AMPA/kainate glutamate receptor antagonists alleviate inflammation, pain and pathology in rat antigen induced arthritis [Abstract]. International Journal of Experimental Pathology 92(6), pp. A14-A14. (10.1111/j.1365-2613.2011.00780.x)
• Jones, G. W., Williams, A. S., Nowell, M. A., Jenkins, B. J. and Jones, S. A. 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B- cell responses [Abstract]. Arthritis and Rheumatism 63(s10), pp. S978-S978. (10.1002/art.33310)
• Evans, L. C., Williams, A. S., Hayes, A. J., Jones, S. A. and Nowell, M. A. 2011. Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthritis. Arthritis and Rheumatism 63(7), pp. 1866-1877. (10.1002/art.30338)

2010

• Leggate, M., Nowell, M. A., Jones, S. A. and Nimmo, M. N. 2010. The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones 15(6), pp. 827-833. (10.1007/s12192-010-0192-z)

2009

• Nowell, M. A. et al. 2009. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 182(1), pp. 613-622.

2008

• Jones, G. W. et al. 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47(S2), pp. II20-II20. (10.1093/rheumatology/kem509)
• Nowell, M. A. and Williams, A. S. 2008. Selective inhibition of PBEF activity with a small molecule inhibitor, APO866 ameliorates collagen-induced arthritis [Abstract]. Rheumatology 47, pp. II58-II59.
• Longhi, M. P. et al. 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4(2), article number: e1000006. (10.1371/journal.ppat.1000006)
• Jones, S. A., Jones, G. W., Williams, A. S. and Nowell, M. A. 2008. Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression. Immunology Endocrine & Metabolic Agents in Medicinal Chemistry 8(3), pp. 235-246.
• Hayes, A. J., Tudor, D., Nowell, M. A., Caterson, B. and Hughes, C. E. 2008. Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. Journal of Histochemistry & Cytochemistry 56(2), pp. 125-38. (10.1369/jhc.7A7320.2007)
• Caterson, B., Hayes, A. J., Tudor, D., Nowell, M. A. and Hughes, C. E. 2008. Chondroitin sulphate motifs as biomarkers for the stem/progenitor cell niche in musculoskeletal tissues. European Cells and Materials 16(Supp 2), pp. 47-47.

2007

• Williams, A. S. et al. 2007. Interferon-γ protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints. Arthritis & Rheumatism 56(7), pp. 2244-2254. (10.1002/art.22732)
• Carty, S. M., Nowell, M. A., Lauder, S. N., Goodfellow, R. M., Jones, S. A., Williams, B. D. and Williams, A. S. 2007. Combination therapy with etanercept and sgp130 for rheumatoid arthritis is more effective than monotherapy [Abstract]. Rheumatology 46(s1), pp. I18-I18. (10.1093/rheumatology/kem1007)
• Campinho, M. A., Silva, N., Nowell, M. A., Llewellyn, L., Sweeney, G. E. and Power, D. M. 2007. Troponin T isoform expression is modulated during Atlantic Halibut metamorphosis. BMC Developmental Biology 7(1), article number: 71. (10.1186/1471-213X-7-71)

2006

• Dimitrov, S. et al. 2006. Sleep enhances IL-6 trans-signaling in humans. The FASEB Journal 20(12), pp. 2174-2176. (10.1096/fj.06-5754fje)
• Carty, S. M., Nowell, M. A., Goodfellow, R. M., Jones, S. A., Williams, B. D. and Williams, A. S. 2006. TINFa and IL-6/slL-6R interactions regulate the magnitude and the phenotype of synovial Leucocyte infiltration in rheumatoid arthritis [Abstract]. Arthritis and Rheumatism 54(9), pp. S597-S597.
• Nowell, M. A. et al. 2006. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Arthritis & Rheumatism 54(7), pp. 2084-2095. (10.1002/art.21942)
• Peake, N. J. et al. 2006. Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor. Rheumatology 45(12), pp. 1485-1489. (10.1093/rheumatology/kel154)
• Richards, P. J. et al. 2006. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis & Rheumatism 54(5), pp. 1662-1672. (10.1002/art.21818)

2005

• Carty, S. M., Nowell, M. A., Goodfellow, R. M., Topley, N., Jones, S. A., Williams, B. D. and Williams, A. S. 2005. Interleukin 6 (IL-6) signalling in rheumatoid arthritis. Rheumatology 44, pp. I38-I38.

2004

• McLoughlin, R. M. et al. 2004. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. The Journal of Immunology 172, pp. 5676-83.

2003

• Nowell, M. A. et al. 2003. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. The Journal of Immunology 171(6), pp. 3202-3209.

2001

• Coffey, M. J. et al. 2001. Catalytic consumption of nitric oxide by 12/15- lipoxygenase: inhibition of monocyte soluble guanylate cyclase activation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 98(14), pp. 8006-8011. (10.1073/pnas.141136098)
• Power, D. M. et al. 2001. Thyroid hormones in growth and development of fish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 130(4), pp. 447-459. (10.1016/S1532-0456(01)00271-X)

2000

• Nowell, M. A., DM, P., PM, G., L, L., V, R., T, W. and Sweeney, G. E. 2000. Cloning and expression of an elongation factor-1a in sea bream (Sparus aurata) larvae and adult tissue. Marine Biotechnology 2(2), pp. 173-179. (10.1007/s101269900022)