![Michael O'Donovan](https://profiles-cardiff.imgix.net/attachments/2529?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Professor Michael O'Donovan
Teams and roles for Michael O'Donovan
Emeritus Professor
Overview
Genetic variation makes important contributions to the aetiology of all major psychiatric disorders. Recent advances in molecular genetic technology offer unprecedented opportunities to identify specific risk genes for these disorders, and to use these findings as the basis for understanding the molecular basis of these hitherto enigmatic disorders. I am interested in identifying genes that contribute to susceptibility to a wide range of psychiatric disorders including schizophrenia, bipolar disorder, ADHD, and Alzheimer’s disease, and exploiting the findings to understanding the pathophysiological processes by which susceptibility is conferred.
Publication
2016
- Bigdeli, T. B. et al., 2016. Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171 (2), pp.276-289. (10.1002/ajmg.b.32402)
- Carroll, L. S. et al., 2016. Mutation screening of SCN2A in schizophrenia and identification of a novel loss-of-function mutation. Psychiatric Genetics 26 (2), pp.60-65. (10.1097/YPG.0000000000000110)
- Corvin, A. and O'Donovan, M. C. 2016. Psychiatric genetics: what's new in 2015?. The Lancet Psychiatry 3 (1), pp.10-12. (10.1016/S2215-0366(15)00571-4)
- Hannon, E. et al., 2016. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nature Neuroscience 19 (1), pp.48-54. (10.1038/nn.4182)
- Hubbard, L. et al. 2016. Evidence of common genetic overlap between schizophrenia and cognition. Schizophrenia Bulletin 42 (3), pp.832-842. (10.1093/schbul/sbv168)
- Jun, G. et al., 2016. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry 21 , pp.108-117. (10.1038/mp.2015.23)
- Lancaster, T. et al. 2016. Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals. Human Brain Mapping 37 (2), pp.491-500. (10.1002/hbm.23044)
- Richards, A. et al. 2016. Exome arrays capture polygenic rare variant contributions to schizophrenia. Human Molecular Genetics 25 (5), pp.1001-1007. (10.1093/hmg/ddv620)
- Tansey, K. E. et al. 2016. Common alleles contribute to schizophrenia in CNV carriers. Molecular Psychiatry 21 , pp.1085-1089. (10.1038/mp.2015.143)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21 , pp.1202-1207. (10.1038/mp.2015.163)
- van Goozen, S. H. M. et al. 2016. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. Journal of Child Psychology and Psychiatry 57 (4), pp.472-480. (10.1111/jcpp.12464)
2015
- Andreassen, O. A. et al., 2015. Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLoS Genetics 11 (11) e1005544. (10.1371/journal.pgen.1005544)
- Arloth, J. et al., 2015. Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders. Neuron 86 (5), pp.1189-1202. (10.1016/j.neuron.2015.05.034)
- Desikan, R. S. et al., 2015. Genetic overlap between Alzheimer's Disease and Parkinson's Disease at the MAPT locus. Molecular Psychiatry 20 (12), pp.1588-1595. (10.1038/mp.2015.6)
- Desikan, R. S. et al., 2015. Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer Disease. Circulation 131 (23), pp.2061-2069. (10.1161/CIRCULATIONAHA.115.015489)
- Escott-Price, V. et al. 2015. No evidence for enrichment in schizophrenia for common allelic associations at imprinted loci. PLoS ONE 10 (12), pp.-. e0144172. (10.1371/journal.pone.0144172)
- Farrell, M. S. et al., 2015. Evaluating historical candidate genes for schizophrenia. Molecular Psychiatry 20 (5), pp.555-562. (10.1038/mp.2015.16)
- Green, E. K. et al., 2015. Copy number variation in bipolar disorder. Molecular Psychiatry 21 (1), pp.89-93. (10.1038/mp.2014.174)
- Hall, J. et al. 2015. Genetic risk for schizophrenia: convergence on synaptic pathways Involved in plasticity. Biological Psychiatry 77 (1), pp.52-68. (10.1016/j.biopsych.2014.07.011)
- Hosp, F. et al., 2015. Quantitative interaction proteomics of neurodegenerative disease proteins. Cell Reports 11 (7), pp.1134-46. (10.1016/j.celrep.2015.04.030)
- Huang, J. et al., 2015. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nature Communications 6 8111. (10.1038/ncomms9111)
- Ingason, A. et al., 2015. Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case?control sample of schizophrenia. Translational Psychiatry 5 (10) e656. (10.1038/tp.2015.151)
- Jones, L. et al. 2015. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's and Dementia 11 (6), pp.658-671. (10.1016/j.jalz.2014.05.1757)
- Kavanagh, D. et al., 2015. Schizophrenia genetics: emerging themes for a complex disorder. Molecular Psychiatry 20 (1), pp.72-76. (10.1038/mp.2014.148)
- Lee, S. H. et al., 2015. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology 44 (5), pp.1706-1721. (10.1093/ije/dyv136)
- Loh, P. et al., 2015. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nature Genetics 47 , pp.1385-1392. (10.1038/ng.3431)
- Maier, R. et al., 2015. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. American Journal of Human Genetics 96 (2), pp.283-294. (10.1016/j.ajhg.2014.12.006)
- Martin, J. et al. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5 e506. (10.1038/tp.2015.5)
- Martin, J. et al. 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 56 (6), pp.648-656. (10.1111/jcpp.12336)
- O'Donovan, M. C. 2015. Novel genetic advances in schizophrenia: an interview with Michael O'Donovan. BMC Medicine 13 181. (10.1186/s12916-015-0417-1)
- O'Donovan, M. C. 2015. What have we learned from the Psychiatric Genomics Consortium. World Psychiatry 14 (3), pp.291-293. (10.1002/wps.20270)
- O'Dushlaine, C. et al., 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 18 (2), pp.199-209. (10.1038/nn.3922)
- Oertel-Knöchel, V. et al., 2015. Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts. NeuroImage: Clinical 7 , pp.764-770. (10.1016/j.nicl.2015.03.005)
- Pocklington, A. et al. 2015. Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia. Neuron 86 (5), pp.1203-1214. (10.1016/j.neuron.2015.04.022)
- Rees, E. et al. 2015. Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia. Translational Psychiatry 5 (7) e607. (10.1038/tp.2015.99)
- Rees, E. , O'Donovan, M. C. and Owen, M. J. 2015. Genetics of schizophrenia. Current Opinion in Behavioral Sciences 2 , pp.8-14. (10.1016/j.cobeha.2014.07.001)
- Schmidts, M. et al., 2015. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications 6 7074. (10.1038/ncomms8074)
- Spiers, H. et al., 2015. Methylomic trajectories across human fetal brain development. Genome Research 25 (3), pp.338-352. (10.1101/gr.180273.114)
- Stergiakouli, E. et al., 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54 (4), pp.322-327. (10.1016/j.jaac.2015.01.010)
- Tansey, K. E. , Owen, M. J. and O'Donovan, M. C. 2015. Schizophrenia genetics: Building the foundations of the future. Schizophrenia Bulletin 41 (1), pp.15-19. (10.1093/schbul/sbu162)
- Taylor, P. N. et al. 2015. Whole-genome sequence-based analysis of thyroid function. Nature Communications 6 5681. (10.1038/ncomms6681)
- Vilhjálmsson, B. et al., 2015. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. American Journal of Human Genetics 97 (4), pp.576-592. (10.1016/j.ajhg.2015.09.001)
- Walter, K. et al., 2015. The UK10K project identifies rare variants in health and disease. Nature 526 , pp.82-90. (10.1038/nature14962)
2014
- Andreassen, O. A. et al., 2014. Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Molecular Psychiatry 20 (2), pp.207. (10.1038/mp.2013.195)
- Bacanu, S. et al., 2014. Functional SNPs are enriched for schizophrenia association signals [Letter]. Molecular Psychiatry 19 (3), pp.276-277. (10.1038/mp.2013.33)
- Craddock, N. J. et al. 2014. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophrenia Bulletin 40 (4), pp.729-736. (10.1093/schbul/sbu069)
- Crawford, A. A. et al., 2014. Adverse effects from antidepressant treatment: randomised controlled trial of 601 depressed individuals. Psychopharmacology 231 (15), pp.2921-2931. (10.1007/s00213-014-3467-8)
- De Rubeis, S. et al., 2014. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515 , pp.209-215. (10.1038/nature13772)
- Escott-Price, V. et al. 2014. Gene-wide analysis detects two new susceptibility genes for Alzheimer's Disease. PLoS ONE 9 (6) e94661. (10.1371/journal.pone.0094661)
- Fromer, M. et al., 2014. De novo mutations in schizophrenia implicate synaptic networks. Nature 506 , pp.179-184. (10.1038/nature12929)
- Georgieva, L. et al. 2014. De novo CNVs in bipolar affective disorder and schizophrenia. Human Molecular Genetics 23 (24), pp.6677-6683. (10.1093/hmg/ddu379)
- Gusev, A. et al., 2014. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. American Journal of Human Genetics 95 (5), pp.535-552. (10.1016/j.ajhg.2014.10.004)
- Hodgson, K. et al., 2014. Genetic predictors of antidepressant side effects: A grouped candidate gene approach in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study. Journal of Psychopharmacology 28 (2), pp.142-150. (10.1177/0269881113517957)
- Kendler, K. S. and O'Donovan, M. C. 2014. A breakthrough in schizophrenia genetics. JAMA Psychiatry 71 (12), pp.1319-1320. (10.1001/jamapsychiatry.2014.1776)
- Liu, G. et al., 2014. Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies. Neurobiology of Aging 35 (4), pp.786-92. (10.1016/j.neurobiolaging.2013.10.084)
- Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53 (7), pp.761-770.e26. (10.1016/j.jaac.2014.03.004)
- Martin, J. et al. 2014. Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders 44 (1), pp.204-215. (10.1007/s10803-013-1865-0)
- Martin, J. et al. 2014. Genetic risk for Attention Deficit/Hyperactivity Disorder contributes to neurodevelopmental traits in the general population. Biological Psychiatry 76 (8), pp.664-671. (10.1016/j.biopsych.2014.02.013)
- Morris, D. W. et al., 2014. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Human Molecular Genetics 23 (12), pp.3316-3326. (10.1093/hmg/ddu025)
- Mulle, J. G. et al., 2014. Reciprocal duplication of the Williams-Beuren Syndrome deletion on chromosome 7q11.23 is associated with schizophrenia. Biological Psychiatry 75 (5), pp.371-7. (10.1016/j.biopsych.2013.05.040)
- Pocklington, A. , O'Donovan, M. C. and Owen, M. J. 2014. The synapse in schizophrenia. European Journal of Neuroscience 39 (7), pp.1059-1067. (10.1111/ejn.12489)
- Rees, E. et al. 2014. CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. Human Molecular Genetics 23 (6), pp.1669-1676. (10.1093/hmg/ddt540)
- Rees, E. et al. 2014. Analysis of copy number variations at 15 schizophrenia-associated loci. British Journal of Psychiatry 204 (2), pp.108-114. (10.1192/bjp.bp.113.131052)
- Robinson, E. B. et al., 2014. Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'. Molecular Psychiatry 19 (8), pp.860-1. (10.1038/mp.2013.125)
- Ruderfer, D. M. et al., 2014. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Molecular Psychiatry 19 (9), pp.1017-1024. (10.1038/mp.2013.138)
- Steinberg, S. et al., 2014. Common variant at 16p11.2 conferring risk of psychosis. Molecular Psychiatry 19 (1), pp.108-114. (10.1038/mp.2012.157)
- Szatkiewicz, J. P. et al., 2014. Copy number variation in schizophrenia in Sweden. Molecular Psychiatry 19 (7), pp.762-773. (10.1038/mp.2014.40)
- Tansey, K. et al. 2014. Genetic susceptibility for bipolar disorder and response to antidepressants in major depressive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 165 (1), pp.77-83. (10.1002/ajmg.b.32210)
- Tansey, K. et al. 2014. Copy number variants and therapeutic response to antidepressant medication in major depressive disorder. The Pharmacogenomics Journal 14 (4), pp.395-399. (10.1038/tpj.2013.51)
- Timpson, N. J. et al., 2014. A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nature Communications 5 4871. (10.1038/ncomms5871)
2013
- Aberg, K. A. et al., 2013. A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry 70 (6), pp.573-581. (10.1001/jamapsychiatry.2013.288)
- Andreassen, O. et al., 2013. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. American Journal of Human Genetics 92 (2), pp.197-209. (10.1016/j.ajhg.2013.01.001)
- Chapman, J. et al., 2013. A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk. Human Molecular Genetics 22 (4), pp.816-824. (10.1093/hmg/dds476)
- Chapuis, J. et al., 2013. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology [Article]. Molecular Psychiatry 18 (11), pp.1225-1234. (10.1038/mp.2013.1)
- de Candia, T. et al., 2013. Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. American Journal of Human Genetics 93 (3), pp.463-470. (10.1016/j.ajhg.2013.07.007)
- Donohoe, G. et al., 2013. Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253. Genes, Brain and Behavior 12 (2), pp.203-209. (10.1111/gbb.12016)
- Gibson, G. et al., 2013. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genetics 9 (4) e1003449. (10.1371/journal.pgen.1003449)
- Green, E. K. et al. 2013. Association at SYNE1 in both bipolar disorder and recurrent major depression. Molecular Psychiatry 18 , pp.614-617. (10.1038/mp.2012.48)
- Green, E. K. et al. 2013. Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. Molecular Psychiatry 18 (12), pp.1302-1307. (10.1038/mp.2012.142)
- Grozeva, D. et al. 2013. Reduced burden of very large and rare CNVs in bipolar affective disorder. Bipolar Disorders 15 (8), pp.893-8. (10.1111/bdi.12125)
- Guha, S. et al., 2013. Implication of a rare deletion at distal 16p11.2 in schizophrenia. JAMA Psychiatry 70 (3), pp.253-260. (10.1001/2013.jamapsychiatry.71)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170 (8), pp.909-916. (10.1176/appi.ajp.2013.12081129)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203 (2), pp.107-111. (10.1192/bjp.bp.112.117432)
- Hamshere, M. L. et al. 2013. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Molecular Psychiatry 18 (6), pp.708-712. (10.1038/mp.2012.67)
- Kavanagh, D. et al., 2013. The ENCODE project: implications for psychiatric genetics. Molecular Psychiatry 18 (5), pp.540-542. (10.1038/mp.2013.13)
- Kim, Y. et al., 2013. Non-random mating, parent-of-origin, and maternal-fetal incompatibility effects in schizophrenia. Schizophrenia Research 143 (1), pp.11-17. (10.1016/j.schres.2012.11.002)
- Kirov, G. et al. 2013. The penetrance of copy number variations for schizophrenia and developmental delay. Biological Psychiatry 75 (5), pp.378-385. (10.1016/j.biopsych.2013.07.022)
- Kronenberg, F. et al., 2013. Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease [Article]. PLoS ONE 8 (4), pp.e59905. (10.1371/journal.pone.0059905)
- Lambert, J. C. et al., 2013. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease [Correction]. Molecular Psychiatry 18 (4), pp.521. (10.1038/mp.2012.75)
- Lambert, J. et al., 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease [Letter]. Nature Genetics 45 (12), pp.1452-1458. (10.1038/ng.2802)
- Landerl, K. et al., 2013. Predictors of developmental dyslexia in European orthographies with varying complexity. Journal of Child Psychology and Psychiatry 54 (6), pp.686-694. (10.1111/jcpp.12029)
- Lee, S. et al., 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45 (9), pp.984-994. (10.1038/ng.2711)
- Majounie, E. et al. 2013. Variation in tau isoform expression in different brain regions and disease states. Neurobiology of Aging 34 (7), pp.1922.e7-1922.e12. (10.1016/j.neurobiolaging.2013.01.017)
- Prata, D. P. et al., 2013. Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity. Human Brain Mapping 34 (9), pp.2025-2031. (10.1002/hbm.22045)
- Rees, E. et al. 2013. Evidence that duplications of 22q11.2 protect against schizophrenia. Molecular Psychiatry n/a (10.1038/mp.2013.156)
- Ripke, S. et al., 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics 45 (10), pp.1150-1159. (10.1038/ng.2742)
- Ripke, S. et al., 2013. A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry 18 (4), pp.497-511. (10.1038/mp.2012.21)
- Ruderfer, D. et al., 2013. Mosaic copy number variation in schizophrenia. European Journal of Human Genetics 21 (9), pp.1007-1011. (10.1038/ejhg.2012.287)
- Smoller, J. W. et al., 2013. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet 381 (9875), pp.1371-1379. (10.1016/S0140-6736(12)62129-1)
- Terwisscha van Scheltinga, A. F. et al., 2013. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry 73 (6), pp.525-531. (10.1016/j.biopsych.2012.08.017)
- van Scheltinga, A. F. T. et al., 2013. Schizophrenia genetic variants are not associated with intelligence. Psychological Medicine 43 (12), pp.2563-2570. (10.1017/S0033291713000196)
- Visscher, P. M. et al., 2013. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genetics 9 (4), pp.e1003455. (10.1371/journal.pgen.1003455)
- Walters, J. T. R. et al. 2013. The role of the major histocompatibility complex region in cognition and brain structure: a schizophrenia GWAS follow-up. American Journal of Psychiatry 170 (8), pp.877-885. (10.1176/appi.ajp.2013.12020226)
- Williams, H. J. et al. 2013. Schizophrenia two-hit hypothesis in velo-cardio facial syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162 (2), pp.177-182. (10.1002/ajmg.b.32129)
- Yang, L. et al., 2013. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162 (5), pp.419-430. (10.1002/ajmg.b.32169)
- Zammit, S. et al. 2013. A population-based study of genetic variation and psychotic experiences in adolescents. Schizophrenia Bulletin 40 (6), pp.1254-1262. (10.1093/schbul/sbt146)
- Zou, F. et al., 2013. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's Disease pathology. PLoS ONE 8 (5) e64802. (10.1371/journal.pone.0064802)
2012
- Ayalew, M. et al., 2012. Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Molecular Psychiatry 17 (9), pp.887-905. (10.1038/mp.2012.37)
- Chapman, R. M. et al., 2012. Inducible over-expression and siRNA mediated knock-down of the schizophrenia susceptibility gene ZNF804A: Detection of altered gene expression and splicing using whole genome exon arrays. International Journal of Developmental Neuroscience 30 (8), pp.673-673. (10.1016/j.ijdevneu.2012.10.011)
- Collins, A. L. et al., 2012. Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. Psychological Medicine 42 (3), pp.607-616. (10.1017/S0033291711001607)
- Cooper, J. D. et al., 2012. Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics 21 (23), pp.5202-5208. (10.1093/hmg/dds357)
- Derks, E. M. et al., 2012. Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis. PLoS ONE 7 (6) e37852. (10.1371/journal.pone.0037852)
- Doherty, J. L. , O'Donovan, M. C. and Owen, M. J. 2012. Recent genomic advances in schizophrenia. Clinical Genetics 81 (2), pp.103-109. (10.1111/j.1399-0004.2011.01773.x)
- Escott-Price, V. et al. 2012. Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis. European Journal of Human Genetics 20 (8), pp.890-896. (10.1038/ejhg.2012.8)
- Eyre, S. et al., 2012. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics 44 (12), pp.1336-1340. (10.1038/ng.2462)
- Fromer, M. et al., 2012. Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth. American Journal of Human Genetics 91 (4), pp.597-607. (10.1016/j.ajhg.2012.08.005)
- Gerrish, A. et al. 2012. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's Disease. Journal of Alzheimer's Disease 28 (2), pp.377-387. (10.3233/JAD-2011-110824)
- Grozeva, D. et al. 2012. Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia. Schizophrenia Research 135 (1-3), pp.1-7. (10.1016/j.schres.2011.11.004)
- Hamilton, G. et al., 2012. The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B (6), pp.696-709. (10.1002/ajmg.b.32073)
- Hamilton, G. et al., 2012. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiology of Aging 33 (8) 1848.e1. (10.1016/j.neurobiolaging.2012.02.005)
- Håvik, B. et al., 2012. DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. PLoS ONE 7 (4), pp.e35424. (10.1371/journal.pone.0035424)
- Hollingworth, P. et al. 2012. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Molecular Psychiatry 17 (12), pp.1316-1327. (10.1038/mp.2011.125)
- Hudson, G. et al., 2012. No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology 78 (14), pp.1038-1042. (10.1212/WNL.0b013e31824e8f1d)
- Jia, P. et al., 2012. A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. Journal of Medical Genetics 49 (2), pp.96-103. (10.1136/jmedgenet-2011-100397)
- Jia, P. et al., 2012. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Computational Biology 8 (7) e1002587. (10.1371/journal.pcbi.1002587)
- Jostins, L. et al., 2012. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491 (7422), pp.119-124. (10.1038/nature11582)
- Keller, M. C. et al., 2012. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. Plos Genetics 8 (4) e1002656. (10.1371/journal.pgen.1002656)
- Kirov, G. et al. 2012. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Molecular Psychiatry 17 (2), pp.142-153. (10.1038/mp.2011.154)
- Lambert, J. C. et al., 2012. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. Molecular Psychiatry 18 , pp.461-470. (10.1038/mp.2012.14)
- Levinson, D. F. et al., 2012. Genome-wide association study of multiplex schizophrenia pedigrees. American Journal of Psychiatry 169 (9), pp.963-973. (10.1176/appi.ajp.2012.11091423)
- O'Donovan, M. C. et al. 2012. Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biological psychiatry 72 (8), pp.620-628. (10.1016/j.biopsych.2012.05.035)
- Rees, E. et al. 2012. De Novo mutation in schizophrenia. Schizophrenia Bulletin 38 (3), pp.377-381. (10.1093/schbul/sbs047)
- Richards, A. et al. 2012. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Molecular Psychiatry 17 (2), pp.193-201. (10.1038/mp.2011.11)
- Shi, H. et al., 2012. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging 33 (8) 1849.e5. (10.1016/j.neurobiolaging.2012.02.014)
- Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169 (2), pp.186-194. (10.1176/appi.ajp.2011.11040551)
- Sullivan, P. et al., 2012. Don't give up on GWAS [Letter]. Molecular Psychiatry 17 (1), pp.2-3. (10.1038/mp.2011.94)
- Sullivan, P. F. , Daly, M. J. and O'Donovan, M. C. 2012. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nature Reviews Genetics 13 (8), pp.537-551. (10.1038/nrg3240)
- Tansey, K. E. et al. 2012. Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. Plos Medicine 9 (10) e1001326. (10.1371/journal.pmed.1001326)
- Williams, H. J. et al. 2012. Absence of de novo point mutations in exons of GRIN2B in a large schizophrenia trio sample [Letter]. Schizophrenia Research 141 (2-3), pp.274-276. (10.1016/j.schres.2012.08.024)
- Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169 (2), pp.195-204. (10.1176/appi.ajp.2011.11060822)
2011
- Bridges, M. et al., 2011. Genetic classification of populations using supervised learning. PLoS ONE 6 (5) e14802. (10.1371/journal.pone.0014802)
- Cardno, A. G. et al., 2011. A genomewide linkage study of age at onset in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B (8), pp.929-940. (10.1002/ajmg.1404)
- Carroll, L. S. et al. 2011. Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (7), pp.844-849. (10.1002/ajmg.b.31231)
- Chen, J. et al., 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131 (1-3), pp.43-51.
- Cichon, S. et al., 2011. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. American Journal of Human Genetics 88 (3), pp.372-381. (10.1016/j.ajhg.2011.01.017)
- Donohoe, G. et al., 2011. A neuropsychological investigation of the genome wide associated schizophrenia risk variant NRGN rs12807809 [Letter]. Schizophrenia Research 125 (2-3), pp.304-306. (10.1016/j.schres.2010.10.019)
- Dwyer, S. L. et al. 2011. Investigation of rare non-synonymous variants at ABCA13 in schizophrenia and bipolar disorder [letter]. Molecular Psychiatry 16 (8), pp.790-791. (10.1038/mp.2011.2)
- Escott-Price, V. et al. 2011. An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction. Biological Psychiatry 70 (2), pp.198-203. (10.1016/j.biopsych.2011.01.034)
- Escott-Price, V. et al. 2011. Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study. Genetic Epidemiology 35 (8), pp.861-866. (10.1002/gepi.20636)
- Green, E. K. et al. 2011. DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B (4), pp.490-492. (10.1002/ajmg.b.31187)
- Hamshere, M. L. et al. 2011. Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (8), pp.929-940. (10.1002/ajmg.b.31240)
- Hamshere, M. L. et al. 2011. Polygenic dissection of the bipolar phenotype. British Journal of Psychiatry 198 (4), pp.284-288. (10.1192/bjp.bp.110.087866)
- Hansen, T. et al., 2011. At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia. Biological Psychiatry 70 (1), pp.59-63. (10.1016/j.biopsych.2011.01.031)
- Hinney, A. et al., 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (8), pp.888-897. (10.1002/ajmg.b.31246)
- Hollingworth, P. et al. 2011. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics 43 (5), pp.429-435. (10.1038/ng.803)
- Ikeda, M. et al., 2011. Genome-Wide Association Study of Schizophrenia in a Japanese Population. Biological Psychiatry 69 (5), pp.472-478. (10.1016/j.biopsych.2010.07.010)
- Ingason, A. et al., 2011. Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness. American Journal of Psychiatry 168 (4), pp.408-417. (10.1176/appi.ajp.2010.09111660)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199 (5), pp.398-403.
- Lewis, G. et al., 2011. Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial. British Journal of Psychiatry 198 (6), pp.464-471. (10.1192/bjp.bp.110.082727)
- Lips, E. S. et al., 2011. Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Molecular Psychiatry , pp.1-11. (10.1038/mp.2011.117)
- O'Dushlaine, C. et al., 2011. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Molecular Psychiatry 16 (3), pp.286-292. (10.1038/mp.2010.7)
- Owen, M. J. et al. 2011. Neurodevelopmental hypothesis of schizophrenia. British Journal of Psychiatry 198 (3), pp.173-175. (10.1192/bjp.bp.110.084384)
- Rees, E. et al. 2011. De novo rates and selection of schizophrenia-associated copy number variants. Biological Psychiatry 70 (12), pp.1109-1114. (10.1016/j.biopsych.2011.07.011)
- Reilly, M. P. et al., 2011. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. The Lancet 377 (9763), pp.383-392. (10.1016/S0140-6736(10)61996-4)
- Rietschel, M. et al., 2011. Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe. Molecular Psychiatry , pp.1-12. (10.1038/mp.2011.80)
- Ripke, S. et al., 2011. Genome-wide association study identifies five new schizophrenia loci [Letter]. Nature Genetics 43 (10), pp.969-976. (10.1038/ng.940)
- Ruderfer, D. M. et al., 2011. A family-based study of common polygenic variation and risk of schizophrenia [Letter]. Molecular Psychiatry 16 (9), pp.887-888. (10.1038/mp.2011.34)
- Sims, R. et al. 2011. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (7), pp.764-771. (10.1002/ajmg.b.31216)
- Sklar, P. et al., 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 [Letter]. Nature Genetics 43 (10), pp.977-983. (10.1038/ng.943)
- Smith, R. L. et al. 2011. Analysis of neurogranin (NRGN) in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B (5), pp.532-535. (10.1002/ajmg.b.31191)
- Steinberg, S. et al., 2011. Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Human Molecular Genetics 20 (20), pp.4076-4081. (10.1093/hmg/ddr325)
- Stergiakouli, E. et al., 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10 (3), pp.334-344. (10.1111/j.1601-183x.2010.00672.x)
- Tognin, S. et al., 2011. Effects of DTNBP1 genotype on brain development in children. Journal of Child Psychology and Psychiatry 52 (12), pp.1287-1294. (10.1111/j.1469-7610.2011.02427.x)
- Wiles, N. J. et al., 2011. Severity of depression and response to antidepressants: GENPOD randomised controlled trial. British Journal of Psychiatry 200 (2), pp.130-136. (10.1192/bjp.bp.110.091223)
- Williams, H. J. et al. 2011. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Human Molecular Genetics 20 (2), pp.387-391. (10.1093/hmg/ddq471)
- Williams, H. J. et al. 2011. Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (7), pp.781-784. (10.1002/ajmg.b.31219)
- Williams, H. J. et al. 2011. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Molecular Psychiatry 16 (4), pp.429-441. (10.1038/mp.2010.36)
- Williams, N. M. et al. 2011. Structural variations in attention-deficit hyperactivity disorder - Authors' reply [Letter]. The Lancet 377 (9763), pp.378. (10.1016/S0140-6736(11)60121-9)
- Yosifova, A. et al., 2011. Genome-wide association study on bipolar disorder in the Bulgarian population. Genes, Brain and Behavior 10 (7), pp.789-797. (10.1111/j.1601-183X.2011.00721.x)
- Zuliani, R. et al., 2011. Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry Research: Neuroimaging 191 (2), pp.133-137. (10.1016/j.pscychresns.2010.11.001)
2010
- Allison, D. B. et al., 2010. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genetics 6 (9) e1001097. (10.1371/journal.pgen.1001097)
- Blake, D. J. et al., 2010. TCF4, Schizophrenia, and Pitt-Hopkins Syndrome. Schizophrenia Bulletin 36 (3), pp.443-447. (10.1093/schbul/sbq035)
- Breuer, R. et al., 2010. Independent evidence for the selective influence of GABAA receptors on one component of the bipolar disorder phenotype [letter]. Molecular Psychiatry 16 (6), pp.587-589. (10.1038/mp.2010.67)
- Carroll, L. S. et al. 2010. Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha. Molecular Psychiatry 15 (11), pp.1101-1111. (10.1038/mp.2009.96)
- Chen, X. et al., 2010. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Molecular Psychiatry 16 (11), pp.1117-1129. (10.1038/mp.2010.96)
- Craddock, N. J. et al. 2010. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 464 (7289), pp.713-720. (10.1038/nature08979)
- Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Molecular Psychiatry 15 (2), pp.146-153. (10.1038/mp.2008.66)
- Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype [Corrigendum]. Molecular Psychiatry 15 (11), pp.1121-1121. (10.1038/mp.2010.62)
- Dwyer, S. L. et al. 2010. No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (8), pp.1411-1416. (10.1002/ajmg.b.31117)
- Escott-Price, V. et al. 2010. Genetic differences between five European populations. Human Heredity 70 (2), pp.141-149. (10.1159/000313854)
- Green, E. K. et al. 2010. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (7), pp.1347-1349. (10.1002/ajmg.b.31108)
- Green, E. K. et al. 2010. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Molecular Psychiatry 15 (10), pp.1016-1022. (10.1038/mp.2009.49)
- Grozeva, D. et al. 2010. Rare copy number variants: A point of rarity in genetic risk for bipolar disorder and schizophrenia. Archives of General Psychiatry 67 (4), pp.318-327. (10.1001/archgenpsychiatry.2010.25)
- Ikeda, M. et al. 2010. Copy number variation in schizophrenia in the Japanese population. Biological Psychiatry 67 (3), pp.283-286. (10.1016/j.biopsych.2009.08.034)
- Ikeda, M. et al. 2010. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biological psychiatry 67 (3), pp.263-269. (10.1016/j.biopsych.2009.08.030)
- Ikeda, M. et al. 2010. Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (4), pp.980-982. (10.1002/ajmg.b.31060)
- Jones, L. et al. 2010. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS ONE 5 (11) e13950. (10.1371/journal.pone.0013950)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196 (3), pp.235-240. (10.1192/bjp.bp.109.066274)
- Langley, K. et al. 2010. Genotype link with extreme antisocial behavior: The contribution of cognitive pathways. Archives of General Psychiatry 67 (12), pp.1317-1323. (10.1001/archgenpsychiatry.2010.163)
- Liu, Y. et al., 2010. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder [Letter]. Molecular Psychiatry 16 (1), pp.2-4. (10.1038/mp.2009.107)
- Mechelli, A. et al., 2010. Dysbindin modulates brain function during visual processing in children. NeuroImage 49 (1), pp.817-822. (10.1016/j.neuroimage.2009.07.030)
- Neale, B. M. et al., 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49 (9), pp.884-897. (10.1016/j.jaac.2010.06.008)
- Owen, M. J. , Craddock, N. J. and O'Donovan, M. C. 2010. Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia. Archives of General Psychiatry 67 (7), pp.667-673. (10.1001/archgenpsychiatry.2010.69)
- Pagnamenta, A. T. et al., 2010. Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biological psychiatry 68 (4), pp.320-328. (10.1016/j.biopsych.2010.02.002)
- Talkowski, M. E. et al., 2010. Fine-mapping reveals novel alternative splicing of the dopamine transporter. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (8), pp.1434-1447. (10.1002/ajmg.b.31125)
- Walters, J. T. R. et al. 2010. Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Archives of General Psychiatry 67 (7), pp.692-700. (10.1001/archgenpsychiatry.2010.81)
- Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376 (9750), pp.1401-1408. (10.1016/S0140-6736(10)61109-9)
2009
- Abraham, R. A. et al. 2009. An association study of common variation at theMAPTlocus with late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (8), pp.1152-1155. (10.1002/ajmg.b.30951)
- Betcheva, E. T. et al., 2009. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. Journal of Human Genetics 54 (2), pp.98-107. (10.1038/jhg.2008.14)
- Carroll, L. S. et al. 2009. Evidence that putative ADHD low risk alleles atSNAP25may increase the risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (7), pp.893-899. (10.1002/ajmg.b.30915)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2009. Psychosis genetics: modeling the relationship between Schizophrenia, Bipolar Disorder, and Mixed (or "Schizoaffective") Psychoses. Schizophrenia Bulletin 35 (3), pp.482-490. (10.1093/schbul/sbp020)
- Donohoe, G. et al., 2009. Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects. Archives of General Psychiatry 66 (10), pp.1045-1054. (10.1001/archgenpsychiatry.2009.139)
- Dwyer, S. L. et al. 2009. Mutation screening of the DTNBP1 exonic sequence in 669 schizophrenics and 710 controls using high-resolution melting analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (3), pp.766-774. (10.1002/ajmg.b.31045)
- Escott-Price, V. et al. 2009. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Molecular Psychiatry 14 (3), pp.252-260. (10.1038/mp.2008.133)
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19 (6), pp.312-319. (10.1097/YPG.0b013e3283328df4)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194 (1), pp.62-67. (10.1192/bjp.bp.107.046870)
- Gerrish, A. et al. 2009. An examination of MUTED as a schizophrenia susceptibility gene [Letter]. Schizophrenia Research 107 (1), pp.110-111. (10.1016/j.schres.2008.08.011)
- Green, E. K. et al. 2009. P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (8), pp.1063-1069. (10.1002/ajmg.b.30931)
- Hamshere, M. L. et al. 2009. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. British Journal of Psychiatry 195 (1), pp.23-29. (10.1192/bjp.bp.108.061424)
- Harold, D. et al. 2009. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Corrigendum]. Nature Genetics 41 (10), pp.1156. (10.1038/ng1009-1156d)
- Harold, D. et al. 2009. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Letter]. Nature Genetics 41 (10), pp.1088-1093. (10.1038/ng.440)
- Hayesmoore, J. B. G. et al. 2009. The effect of age and the H1c MAPT haplotype on MAPT expression in human brain. Neurobiology of Aging 30 (10), pp.1652-1656. (10.1016/j.neurobiolaging.2007.12.017)
- Holmans, P. A. et al. 2009. Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. American Journal of Human Genetics 85 (1), pp.13-24. (10.1016/j.ajhg.2009.05.011)
- Holmans, P. A. et al. 2009. Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms. Molecular Psychiatry 14 (8), pp.786-795. (10.1038/mp.2009.11)
- Ingason, A. et al., 2009. A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Human Molecular Genetics 19 (7), pp.1379-1386. (10.1093/hmg/ddq009)
- Kirov, G. et al. 2009. Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Human Molecular Genetics 18 (8), pp.1497-1503. (10.1093/hmg/ddp043)
- Kirov, G. et al. 2009. Neurexin 1 (NRXN1) deletions in Schizophrenia. Schizophrenia Bulletin 35 (5), pp.851-854. (10.1093/schbul/sbp079)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18 (1), pp.26-32. (10.1007/s00787-008-0698-4)
- Liu, Y. et al., 2009. Whole genome association study in a homogenous population in Shandong Peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia. Journal of Biomedicine and Biotechnology 536918. (10.1155/2009/536918)
- McCarthy, S. E. et al., 2009. Microduplications of 16p11.2 are associated with schizophrenia. Nature Genetics 41 (11), pp.1223-1227. (10.1038/ng.474)
- Morgan, A. R. et al. 2009. Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (1), pp.61-64. (10.1002/ajmg.b.30768)
- Ng, M. Y. M. et al., 2009. Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Molecular Psychiatry 14 (8), pp.774-785. (10.1038/mp.2008.135)
- O'Donovan, M. C. , Craddock, N. J. and Owen, M. J. 2009. Genetics of psychosis; insights from views across the genome. Human Genetics 126 (1), pp.3-12. (10.1007/s00439-009-0703-0)
- O'Donovan, M. C. , Craddock, N. J. and Owen, M. J. 2009. Strong evidence for multiple psychosis susceptibility genes - a rejoinder to Crow [Letter]. Psychological Medicine 39 (1), pp.170-171. (10.1017/S0033291708004583)
- O'Donovan, M. C. et al. 2009. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry 14 (1), pp.30-36. (10.1038/mp.2008.108)
- O'Donovan, M. C. and Owen, M. J. 2009. Genetics and the brain: many pathways to enlightenment [Editorial]. Human Genetics 126 (1), pp.1-2. (10.1007/s00439-009-0705-y)
- Orozco, G. et al., 2009. Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Human Molecular Genetics 18 (14), pp.2693-2699. (10.1093/hmg/ddp193)
- Owen, M. J. , Williams, H. J. and O'Donovan, M. C. 2009. Schizophrenia genetics: advancing on two fronts. Current Opinion in Genetics & Development 19 (3), pp.266-270. (10.1016/j.gde.2009.02.008)
- Purcell, S. M. et al., 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460 (7256), pp.748-752. (10.1038/nature08185)
- Sims, R. et al. 2009. Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease. Neuroscience Letters 461 (1), pp.54-59. (10.1016/j.neulet.2009.05.051)
- Talkowski, M. E. et al., 2009. Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (4), pp.560-569. (10.1002/ajmg.b.30862)
- Williams, H. , Owen, M. J. and O'Donovan, M. C. 2009. Schizophrenia genetics: new insights from new approaches. British Medical Bulletin 91 (1), pp.61-74. (10.1093/bmb/ldp017)
- Williams, H. J. , Owen, M. J. and O'Donovan, M. C. 2009. New findings from genetic association studies of schizophrenia. Journal of Human Genetics 54 (1), pp.9-14. (10.1038/jhg.2008.7)
- Yosifova, A. et al., 2009. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. Journal of Affective Disorders 117 (1-2), pp.87-97. (10.1016/j.jad.2008.12.021)
2008
- Abraham, R. et al., 2008. A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Medical Genomics 1 (1) 44. (10.1186/1755-8794-1-44)
- Barton, A. et al., 2008. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Human Molecular Genetics 17 (15), pp.2274-2279. (10.1093/hmg/ddn128)
- Barton, A. et al., 2008. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics 40 (10), pp.1156-1159. (10.1038/ng.218)
- Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17 (8), pp.1169-1174. (10.1093/hmg/ddn006)
- Buxbaum, J. D. et al., 2008. Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Molecular psychiatry 13 , pp.162-172. (10.1038/sj.mp.4001991)
- Caspi, A. et al., 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 65 (2), pp.203-210. (10.1001/archgenpsychiatry.2007.24)
- Craddock, N. J. et al. 2008. Authors' reply. The British Journal of Psychiatry 193 (6), pp.517. (10.1192/bjp.193.6.517)
- Craddock, N. J. et al. 2008. Wake-up call for British psychiatry. British Journal of Psychiatry 193 (1), pp.6-9. (10.1192/bjp.bp.108.053561)
- Craddock, N. J. et al. 2008. Wake up call: Response from authors [eLetter]. British Journal of Psychiatry
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2008. Genome-wide association studies in psychiatry: lessons from early studies of non-psychiatric and psychiatric phenotypes [Guest Editorial]. Molecular Psychiatry 13 (7), pp.649-653. (10.1038/mp.2008.45)
- Fekadu, A. et al., 2008. Validity of the concept of minor depression in a developing country setting. Journal of Nervous and Mental Disease 196 (1), pp.22-28. (10.1097/NMD.0b013e31815fa4d4)
- Ferreira, M. A. R. et al., 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 40 (9), pp.1056-1058. (10.1038/ng.209)
- Fisher, S. A. et al., 2008. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics 40 (6), pp.710-712. (10.1038/ng.145)
- Georgieva, L. et al. 2008. Support for Neuregulin 1 as a susceptibility gene for Bipolar disorder and schizophrenia. Biological psychiatry 64 (5), pp.419-427. (10.1016/j.biopsych.2008.03.025)
- Hayesmoore, J. B. et al. 2008. DISC1mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (7), pp.1065-1069. (10.1002/ajmg.b.30715)
- Ikeda, M. et al., 2008. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics 9 (10), pp.1437-1443. (10.2217/14622416.9.10.1437)
- Kirov, G. et al. 2008. Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Human Molecular Genetics 17 (3), pp.458-465. (10.1093/hmg/ddm323)
- Kirov, G. et al. 2008. A genome-wide association study in 574 schizophrenia trios using DNA pooling. Molecular Psychiatry 14 (8), pp.796-803. (10.1038/mp.2008.33)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (1), pp.49-53. (10.1002/ajmg.b.30571)
- Li, Y. et al., 2008. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human Molecular Genetics 17 (5), pp.759-767. (10.1093/hmg/ddm348)
- Li, Y. et al., 2008. SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiology of Disease 29 (2), pp.293-296. (10.1016/j.nbd.2007.09.001)
- Loos, R. J. F. et al., 2008. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 40 (6), pp.768-775. (10.1038/ng.140)
- O'Donovan, M. C. et al. 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics 40 (9), pp.1053-1055. (10.1038/ng.201)
- O'Donovan, M. C. , Craddock, N. J. and Owen, M. J. 2008. Schizophrenia: complex genetics, not fairy tales. Psychological Medicine 38 (12), pp.1697-1699. (10.1017/S0033291708003802)
- O'Donovan, M. C. , Kirov, G. and Owen, M. J. 2008. Phenotypic variations on the theme of CNVs. Nature Genetics 40 (12), pp.1392-1393. (10.1038/ng1208-1392)
- Richards, A. L. et al. 2008. A comparison of four clustering methods for brain expression microarray data. BMC Bioinformatics 9 490. (10.1186/1471-2105-9-490)
- Shifman, S. et al., 2008. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLOS Genetics 4 (2) e28. (10.1371/journal.pgen.0040028)
- Stone, J. L. et al., 2008. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455 (7210), pp.237-241. (10.1038/nature07239)
- Thomas, L. et al., 2008. GENetic and clinical predictors of treatment response in depression: the GenPod randomised trial protocol. Trials 9 (1), pp.29-29. (10.1186/1745-6215-9-29)
- Williams, N. M. et al. 2008. Strong evidence that GNB1L is associated with schizophrenia. Human Molecular Genetics 17 (4), pp.555-566. (10.1093/hmg/ddm330)
- Williams, N. M. et al. 2008. Analysis of copy number variation using quantitative interspecies competitive PCR. Nucleic Acids Research 36 (17), pp.e112-e112. (10.1093/nar/gkn495)
- Zaharieva, I. et al., 2008. Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping. BMC Psychiatry 8 (1), pp.11-11. (10.1186/1471-244X-8-11)
2007
- Burton, P. R. et al., 2007. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics 39 (11), pp.1329-1337. (10.1038/ng.2007.17)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2007. Phenotypic and genetic complexity of psychosis Invited commentary on ... Schizophrenia: a common disease caused by multiple rare alleles. British Journal of Psychiatry 190 (3), pp.200-203. (10.1192/bjp.bp.106.033761)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2007. Symptom dimensions and the Kraepelinian dichotomy. British Journal of Psychiatry 190 (4), pp.361. (10.1192/bjp.190.4.361)
- Domschke, K. et al., 2007. Meta-analysis of COMT val158met in panic disorder: Ethnic heterogeneity and gender specificity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (5), pp.667-673. (10.1002/ajmg.b.30494)
- Escott-Price, V. and O'Donovan, M. C. 2007. Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation. Human Heredity 64 (1), pp.63-73. (10.1159/000101424)
- Grupe, A. et al., 2007. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics 16 (8), pp.865-873. (10.1093/hmg/ddm031)
- Gunnell, D. et al., 2007. IGF1, growth pathway polymorphisms and schizophrenia: A pooling study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (1), pp.117-120. (10.1002/ajmg.b.30396)
- Hamilton, G. et al., 2007. Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (4), pp.508-516. (10.1002/ajmg.b.30503)
- Hamilton, G. et al., 2007. Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease. Neuromolecular Medicine 9 (4), pp.331-334. (10.1007/s12017-007-8013-y)
- Hamshere, M. L. et al. 2007. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics Advanc , pp.1-34. (10.1093/hmg/ddm224)
- Harold, D. et al. 2007. Interaction between theADAM12 andSH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (4), pp.448-452. (10.1002/ajmg.b.30456)
- Hollingworth, P. et al., 2007. Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (7), pp.841-848. (10.1002/ajmg.b.30515)
- Morgan, A. et al., 2007. Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (6), pp.727-731. (10.1002/ajmg.b.30670)
- Morgan, A. et al., 2007. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (6), pp.762-770. (10.1002/ajmg.b.30509)
- Nejentsev, S. et al., 2007. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450 (7171), pp.887-892. (10.1038/nature06406)
- Norton, N. et al., 2007. Association analysis of AKT1 and schizophrenia in a UK case control sample. Schizophrenia Research 93 (1-3), pp.58-65. (10.1016/j.schres.2007.02.006)
- O'Donovan, M. C. et al. 2007. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia [Conference Abstract]. Schizophrenia bulletin 33 (2), pp.311-312. (10.1093/schbul/sbm004)
- Talkowski, M. E. et al., 2007. A network of dopaminergic gene variations implicated as risk factors for schizophrenia. Human Molecular Genetics 17 (5), pp.747-758. (10.1093/hmg/ddm347)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64 (3), pp.378-379. (10.1001/archpsyc.64.3.378-b)
- Thapar, A. et al. 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19 (04), pp.989-1004. (10.1017/S0954579407000491)
- Thapar, A. et al. 2007. Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine 37 (12), pp.1681-1692. (10.1017/S0033291707000773)
- Thomson, W. et al., 2007. Rheumatoid arthritis association at 6q23. Nature Genetics 39 (12), pp.1431-1433. (10.1038/ng.2007.32)
- Williams, H. et al., 2007. Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia. Schizophrenia Research 97 (1-3), pp.271-276. (10.1016/j.schres.2007.09.004)
- Williams, H. , Owen, M. J. and O'Donovan, M. C. 2007. Is COMT a susceptibility gene for schizophrenia?. Schizophrenia Bulletin 33 (3), pp.635-641. (10.1093/schbul/sbm019)
- Zammit, S. et al. 2007. Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. British Journal of Psychiatry 191 (5), pp.402-407. (10.1192/bjp.bp.107.036129)
2006
- Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B (7), pp.723-724.
- Bray, N. J. and O'Donovan, M. C. 2006. Investigating cis-acting regulatory variation using assays of relative allelic expression. Psychiatric Genetics 16 (4), pp.173-177. (10.1097/01.ypg.0000218612.35139.84)
- Craddock, N. J. , Owen, M. J. and O'Donovan, M. C. 2006. The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons. Molecular Psychiatry 11 (5), pp.446-458. (10.1038/sj.mp.4001808)
- Escott-Price, V. et al. 2006. Effects of differential genotyping error rate on the Type 1 error probability of case-control studies. Human heredity 61 (1), pp.55-64. (10.1159/000092553)
- Georgieva, L. et al. 2006. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 103 (33), pp.12469-12474. (10.1073/pnas.0603029103)
- Glaser, B. et al., 2006. Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility. Schizophrenia Research 87 (1-3), pp.21. (10.1016/j.schres.2006.05.024)
- Green, E. K. et al., 2006. Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation. Molecular Psychiatry 11 (9), pp.798-799. (10.1038/sj.mp.4001853)
- Green, E. K. et al., 2006. Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK. British Journal of Psychiatry 188 (1), pp.21-25. (10.1192/bjp.bp.105.009969)
- Grupe, A. et al., 2006. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. The American Journal of Human Genetics 78 (1), pp.78-88.
- Hamilton, G. et al., 2006. Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Neuroscience Letters 401 (1-2), pp.77-80. (10.1016/j.neulet.2006.03.021)
- Hamshere, M. L. et al. 2006. Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes. Journal of Medical Genetics 43 (7), pp.563-567. (10.1136/jmg.2005.035345)
- Harold, D. et al., 2006. Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. Molecular Psychiatry 11 (12), pp.1085-91. (10.1038/sj.mp.4001904)
- Harold, D. et al. 2006. A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacogenetics and genomics 16 (2), pp.75-77.
- Khan, I. A. et al. 2006. In silico discrimination of single nucleotide polymorphisms and pathological mutations in human gene promoter regions by means of local DNA sequence context and regularity.. In silico Biology 6 (1-2), pp.23-34.
- Kirov, G. et al. 2006. Pooled DNA genotyping on Affymetrix SNP genotyping arrays. BMC Genomics 7 (1), pp.27-37. (10.1186/1471-2164-7-27)
- Li, Y. et al., 2006. DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Human Molecular Genetics 15 (17), pp.2560-2568. (10.1093/hmg/ddl178)
- Norton, N. et al. 2006. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B (1), pp.96-101. (10.1002/ajmg.b.30236)
- O'Donovan, M. et al. 2006. Genetic dissection of behavioural abnormalities in mouse models of DiGeorge/velocardiofacial syndrome. Journal of intellectual disability research 50 (11), pp.781 -781.
- Paylor, R. et al., 2006. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: Implications for 22q11 deletion syndrome. Proceedings of the National Academy of Sciences of the United States of America 103 (20), pp.7729-7734. (10.1073/pnas.0600206103)
- Peirce, T. R. et al. 2006. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of general psychiatry 63 (1), pp.18-24. (10.1001/archpsyc.63.1.18)
- Peirce, T. et al., 2006. Convergent evidence for 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of General Psychiatry 63 (1), pp.18-24.
- Smemo, S. et al., 2006. Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Annals of Neurology 59 (1), pp.21-26. (10.1002/ana.20673)
- Talkowski, M. E. et al., 2006. Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. Biological psychiatry 60 (2), pp.152-162. (10.1016/j.biopsych.2006.02.015)
- Thapar, A. et al. 2006. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 11 (8), pp.714-20. (10.1038/sj.mp.4001831)
- Williams, J. and O'Donovan, M. C. 2006. The genetics of developmental dyslexia. European Journal of Human Genetics 14 (6), pp.681-89. (10.1038/sj.ejhg.5201575)
- Williams, N. M. et al. 2006. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Archives of General Psychiatry 63 (4), pp.366-373. (10.1001/archpsyc.63.4.366)
- Williams, N. M. , O'Donovan, M. C. and Owen, M. J. 2006. Chromosome 22 deletion syndrome and schizophrenia. International Review of Neurobiology 73 , pp.1-27. (10.1016/S0074-7742(06)73001-X)
- Zammit, S. et al. 2006. Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia. Journal of Psychiatric Research 40 (7), pp.622-626. (10.1016/j.jpsychires.2005.05.006)
2005
- Bray, N. J. et al. 2005. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Human Molecular Genetics 14 (14), pp.1947-1954. (10.1093/hmg/ddi199)
- Buckland, P. R. et al. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26 (3), pp.214-223. (10.1002/humu.20207)
- Buckland, P. R. et al. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162 (3), pp.613-615. (10.1176/appi.ajp.162.3.613)
- Cope, N. A. et al., 2005. No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia. Molecular Psychiatry 10 (3), pp.237-238. (10.1038/sj.mp.4001596)
- Cope, N. A. et al., 2005. Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. American Journal of Human Genetics 76 (4), pp.581-591. (10.1086/429131)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2005. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophrenia Bulletin 32 (1), pp.9-16. (10.1093/schbul/sbj033)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2005. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. Journal of Medical Genetics 42 (3), pp.193-204. (10.1136/jmg.2005.030718)
- Escott-Price, V. et al. 2005. Streamlined analysis of pooled genotype data in SNP-based association studies. Genetic Epidemiology 28 (3), pp.273-282. (10.1002/gepi.20062)
- Glaser, B. et al., 2005. Identification of a potential Bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. Molecular Psychiatry 10 (10), pp.920-927. (10.1038/sj.mp.4001689)
- Glaser, B. et al., 2005. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. Biological psychiatry 58 (1), pp.78-80.
- Gough, S. C. and O'Donovan, M. C. 2005. Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?. Journal of Psychopharmacology 19 (6), pp.47-55. (10.1177/0269881105058380)
- Green, E. et al., 2005. Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease. American Journal of Psychiatry 162 (1), pp.35-42. (10.1176/appi.ajp.162.1.35)
- Green, E. K. et al. 2005. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Archives of general psychiatry 62 (6), pp.642-648. (10.1001/archpsyc.62.6.642)
- Hamshere, M. L. et al. 2005. Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Archives of general psychiatry 62 (10), pp.1081-1088. (10.1001/archpsyc.62.10.1081)
- Holmans, P. A. et al. 2005. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B (1), pp.24-32. (10.1002/ajmg.b.30114)
- Kent, L. et al., 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10 (10), pp.939-943. (10.1038/sj.mp.4001696)
- Kirov, G. , O'Donovan, M. C. and Owen, M. J. 2005. Finding schizophrenia genes. The Journal of Clinical Investigation 115 (6), pp.1440-1448. (10.1172/JCI24759)
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B (1), pp.7-10. (10.1002/ajmg.b.30206)
- Li, Y. et al., 2005. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Human Mutation 25 (3), pp.270-277. (10.1002/humu.20138)
- Norton, N. et al., 2005. No evidence for association between polymorphisms in GRM3 and schizophrenia. BMC Psychiatry 5 23. (10.1186/1471-244X-5-23)
- Nowotny, P. et al., 2005. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 136B (1), pp.62-68. (10.1002/ajmg.b.30186)
- O'Donovan, M. C. 2005. An evaluation of chromatin condensation and DNA integrity in the spermatozoa of men with cancer before and after therapy. Andrologia -Berlin- 37 (2-3), pp.83-90. (10.1111/j.1439-0272.2005.00658.x)
- Owen, M. J. , Craddock, N. J. and O'Donovan, M. C. 2005. Schizophrenia: genes at last?. Trends in Genetics 21 (9), pp.518-525. (10.1016/j.tig.2005.06.011)
- Owen, M. J. , O'Donovan, M. C. and Harrison, P. J. 2005. Schizophrenia: a genetic disorder of the synapse?. British Medical Journal (BMJ) 330 (7484), pp.158-159. (10.1136/bmj.330.7484.158)
- Raybould, R. et al. 2005. Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biological psychiatry 57 (7), pp.696-701. (10.1016/j.biopsych.2005.01.018)
- Redfern, A. et al., 2005. Global gene expression profiling in the hippocampus and frontal cortex of Escitalopram-treated Learned Helplessness rats. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 138B (1), pp.107-107.
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62 (11), pp.1275-1278. (10.1001/archpsyc.62.11.1275)
- Thapar, A. , O'Donovan, M. C. and Owen, M. J. 2005. The genetics of attention deficit hyperactivity disorder. Human Molecular Genetics 14 (2), pp.275-282. (10.1093/hmg/ddi263)
- Turic, D. et al., 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57 (11), pp.1461-1466. (10.1016/j.biopsych.2005.03.025)
- Turic, D. et al., 2005. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B (1), pp.64-67. (10.1002/ajmg.b.30123)
- Williams, H. J. et al., 2005. No association between schizophrenia and polymorphisms in COMT in two large samples. American Journal of Psychiatry 162 (9), pp.1736-1738. (10.1176/appi.ajp.162.9.1736)
- Williams, N. M. , O'Donovan, M. C. and Owen, M. J. 2005. Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?. Schizophrenia Bulletin 31 (4), pp.800-805. (10.1093/schbul/sbi061)
2004
- Bray, N. J. et al. 2004. The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Molecular Psychiatry 9 (1), pp.109-114. (10.1038/sj.mp.4001366)
- Bray, N. J. et al. 2004. Allelic expression of APOE in brain [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.61-61.
- Bray, N. J. et al. 2004. P4-101 Allelic expression of APOE in brain [Conference Abstract]. Neurobiology of Aging 25 , pp.S503-S503. (10.1016/S0197-4580(04)81659-2)
- Bray, N. J. et al. 2004. Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes. Human Molecular Genetics 13 (22), pp.2885-2892. (10.1093/hmg/ddh299)
- Bray, N. J. et al. 2004. Allelic variation in the expression of neuropsychiatric candidate genes [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.25-25.
- Buckland, P. R. et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690 (3), pp.238-249.
- Busby, V. et al., 2004. Alpha-T-Catenin Is Expressed in Human Brain and Interacts With the Wnt Signaling Pathway But Is Not Responsible for Linkage to Chromosome 10 in Alzheimer's Disease. Neuromolecular Medicine 5 (2), pp.133-146. (10.1385/NMM:5:2:133)
- Cichon, S. et al., 2004. Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nature Genetics 36 (8), pp.783-784. (10.1038/ng0804-783)
- Fowler, T. A. et al., 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.98-98. (10.1002/ajmg.b.30101)
- Guy, C. et al. 2004. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 14 (1), pp.45-51. (10.1097/00008571-200401000-00005)
- Hoogendoorn, B. et al. 2004. Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation 24 (1), pp.35-42. (10.1002/humu.20061)
- Huezo-Diaz, P. et al., 2004. An association study of the neurotensin receptor gene with schizophrenia and clozapine response. Schizophrenia Research 66 (2-3), pp.193-195. (10.1016/S0920-9964(03)00128-2)
- Kirov, G. et al. 2004. Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biological psychiatry 55 (10), pp.971-975. (10.1016/j.biopsych.2004.01.025)
- Langley, K. et al. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161 (1), pp.133-138. (10.1176/appi.ajp.161.1.133)
- Mills, S. et al., 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4 , pp.15-15. (10.1186/1471-244X-4-15)
- Morris, D. et al., 2004. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. American Journal Of Medical Genetics Part A 129B (1), pp.97-103. (10.1002/ajmg.b.30033)
- Mowry, B. J. et al., 2004. Multicenter linkage study of schizophrenia loci on chromosome 22q. Molecular Psychiatry 9 (8), pp.784-795. (10.1038/sj.mp.4001481)
- Murphy, K. et al., 2004. What can velo-cardio-facial syndrome tell us about the genetics of schizophrenia?. European Psychiatry 19 (Supp1), pp.96S-96S.
- Myers, A. J. et al., 2004. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics 124B (1), pp.29-37. (10.1002/ajmg.b.20036)
- Norton, N. et al., 2004. Interaction between neuregulin 1 and its receptor ERBB4 increases susceptibility to schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.18-18.
- Norton, N. et al., 2004. DNA pooling as a tool for large-scale association studies in complex traits. Annals of Medicine 36 (2), pp.146-152. (10.1080/07853890310021724)
- Owen, M. J. , Williams, N. M. and O'Donovan, M. C. 2004. Dysbindin-1 and schizophrenia: from genetics to neuropathology. The Journal of Clinical Investigation 113 (9), pp.1255-1257. (10.1172/JCI200421470)
- Owen, M. J. , Williams, N. M. and O'Donovan, M. C. 2004. The molecular genetics of schizophrenia: new findings promise new insights. Molecular Psychiatry 9 (1), pp.14-27. (10.1038/sj.mp.4001444)
- Peirce, T. R. et al., 2004. Convergent functional genomics, association and linkage analysis suggests 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase (CNP) as a potential susceptibility gene for schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.81-81. (10.1002/ajmg.b.30101)
- Plomin, R. et al., 2004. A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability. Molecular Psychiatry 9 (6), pp.582-586. (10.1038/sj.mp.4001441)
- Turic, D. et al., 2004. Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD. American Journal of Medical Genetics 127B (1), pp.68-72. (10.1002/ajmg.b.20173)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9 (2), pp.169-173. (10.1038/sj.mp.4001387)
- Williams, N. M. et al. 2004. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Archives of General Psychiatry 61 (4), pp.336-344. (10.1001/archpsyc.61.4.336)
- Williams, N. M. et al. 2004. Identification in two independent samples of a novel schizophrenia risk haplotype of the dystobrevin binding protein gene (DTNBP1). Archives of general psychiatry 61 (4), pp.336-344. (10.1001/archpsyc.61.4.336)
- Williams, N. M. et al. 2004. Support for RGS4 as a susceptibility gene for schizophrenia. Biological Psychiatry 55 (2), pp.192-195. (10.1016/j.biopsych.2003.11.002)
- Zammit, S. et al. 2004. Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. American Journal of Medical Genetics 128B (1), pp.19-20. (10.1002/ajmg.b.30021)
2003
- Bray, N. B. et al. 2003. Cis-acting variation in the expression of a high proportion of genes in human brain. Human Genetics 113 (2), pp.149-153. (10.1007/s00439-003-0956-y)
- Bray, N. J. et al. 2003. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. The American Journal of Human Genetics 73 (1), pp.152-161. (10.1086/376578)
- Buckland, P. R. et al. 2003. A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expression 11 (5), pp.233-239. (10.3727/000000003783992225)
- Harold, D. et al. 2003. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Human Genetics 113 (3), pp.258-267. (10.1007/s00439-003-0960-2)
- Hoogendoorn, B. et al. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12 (18), pp.2249-2254. (10.1093/hmg/ddg246)
- Ivanov, D. et al. 2003. Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis: Molecular genetic study. The British Journal of Psychiatry 183 (5), pp.409-413. (10.1192/bjp.183.5.409)
- Kirov, G. et al. 2003. Variation in the protocadherin - A gene cluster?. Genomics 82 (4), pp.433-440. (10.1016/S0888-7543(03)00167-8)
- Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13 (2), pp.107-110. (10.1097/01.ypg.0000056177.32550.a5)
- Lawson, D. C. et al., 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B (1), pp.84-89. (10.1002/ajmg.b.10002)
- Lewis, C. M. et al., 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder, Part II: schizophrenia. American Journal of Human Genetics 73 (1), pp.34-48. (10.1086/376549)
- Norton, N. et al., 2003. Mutation screening of the Homer gene family and association analysis in schizophrenia. American Journal of Medical Genetics 120B (1), pp.18-21. (10.1002/ajmg.b.20032)
- O'Donovan, M. C. , Jones, I. R. and Craddock, N. J. 2003. Anticipation and repeat expansion in bipolar disorder. American Journal of Medical Genetics 123C (1), pp.10-17. (10.1002/ajmg.c.20009)
- O'Donovan, M. C. and Owen, M. J. 2003. Genetic findings in psychotic disorders. In: Soares, J. C. and Gershon, S. eds. Handbook of Medical Psychiatry. New York: Marcel Dekker. , pp.417-432.
- O'Donovan, M. C. , Williams, N. M. and Owen, M. J. 2003. Recent advances in the genetics of schizophrenia. Human Molecular Genetics 12 (suppl), pp.R125-R133. (10.1093/hmg/ddg302)
- Owen, M. J. and O'Donovan, M. C. 2003. Schizophrenia and genetics. In: Plomin, R. et al., Behavioral Genetics in the Postgenomic Era. Washington, DC: APA Books. , pp.463-480. (10.1037/10480-023)
- Payton, A. et al., 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13 (3), pp.183-185.
- Smith, S. K. et al. 2003. Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission. Psychiatric Genetics 13 (4), pp.193-199. (10.1097/00041444-200312000-00001)
- Thapar, A. et al. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33 (6), pp.721-721.
- Turic, D. et al., 2003. Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22. Molecular Psychiatry 8 (2), pp.176-185. (10.1038/sj.mp.4001216)
- Williams, H. J. et al., 2003. Association between PRODH and schizophrenia is not confirmed. Molecular Psychiatry 8 (7), pp.644-645. (10.1038/sj.mp.4001276)
- Williams, H. et al., 2003. Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia. American Journal of Medical Genetics 120B (1), pp.42-46. (10.1002/ajmg.b.20049)
- Williams, N. M. et al. 2003. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. The American journal of human genetics 73 (6), pp.1355-1367. (10.1086/380206)
- Williams, N. M. et al. 2003. Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Molecular Psychiatry 8 (5), pp.485-487. (10.1038/sj.mp.4001348)
2002
- Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7 (5), pp.493-502. (10.1038/sj.mp.4001003)
- Bray, N. J. et al. 2002. Detection of cis-acting polymorphisms and epigenetic modification affecting gene expression [Conference Abstracts]. American Journal of Medical Genetics 114 (7), pp.750-750. (10.1002/ajmg.10971)
- Bray, N. J. et al. 2002. Screening the human protocadherin 8 (PCDH8) gene in schizophrenia. Genes, Brain and Behavior 1 (3), pp.187-191. (10.1034/j.1601-183X.2002.10307.x)
- Bray, N. J. et al. 2002. Screening the protocadherin 8 (PCDH8) gene in schizophrenia [Conference Abstract]. American Journal of Medical Genetics 114 (7), pp.844-844.
- Coleman, S. L. et al. 2002. Experimental analysis of the annotation of promoters in the public database. Human Molecular Genetics 11 (16), pp.1817-1821. (10.1093/hmg/11.16.1817)
- Coleman, S. L. et al. 2002. Streamlined approach to functional analysis of promoter-region polymorphisms. Biotechniques 33 (2), pp.412-418.
- Hawi, Z. et al., 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Molecular Psychiatry 7 (7), pp.718-725. (10.1038/sj.mp.4001048)
- Levinson, D. F. et al., 2002. No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science 296 (5568), pp.739-741. (10.1126/science.1069914)
- Norton, N. et al., 2002. Schizophrenia and functional polymorphisms in the MAOA and COMT genes: No evidence for association or epistasis. American Journal Of Medical Genetics Part A 114 (5), pp.491-496. (10.1002/ajmg.10517)
- Norton, N. et al., 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110 (5), pp.471-478. (10.1007/s00439-002-0706-6)
- Sham, P. et al., 2002. DNA Pooling: a tool for large-scale association studies. Nature Reviews Genetics 3 (11), pp.862-871. (10.1038/nrg930)
- Thapar, A. and O'Donovan, M. C. 2002. Neurogenetics. In: D'haenen, H. , den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley. , pp.167-180. (10.1002/0470854871.chxii)
- West, A. et al., 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7 (9), pp.962-966. (10.1038/sj.mp.4001129)
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7 (5), pp.508-514. (10.1038/sj.mp.4001030)
- Williams, N. M. , O'Donovan, M. C. and Owen, M. J. 2002. Genome scans and microarrays: converging on genes for schizophrenia?. Genome Biology 3 (4), pp.Reviews1011-Reviews1011.5.
- Williams, N. M. et al. 2002. Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach. Molecular Psychiatry 7 (10), pp.1092-1100. (10.1038/sj.mp.4001188)
- Zammit, S. , O'Donovan, M. C. and Owen, M. J. 2002. Neurogenetics of schizophrenia. In: D'haenen, H. , den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley. , pp.663-671. (10.1002/0470854871.chxvii9)
2001
- Abraham, R. et al., 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109 (6), pp.646-652. (10.1007/s00439-001-0614-1)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6 (3), pp.259-260. (10.1038/sj.mp.4000128)
- Jacobsen, N. J. O. et al., 2001. Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder. Molecular Psychiatry 6 (1), pp.92-97. (10.1038/sj.mp.4000774)
- Jacobsen, N. J. O. et al., 2001. CUX2, a potential regulator of NCAM expression: Genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder. American Journal of Medical Genetics 105 (3), pp.295-300. (10.1002/ajmg.1325)
- Jurewicz, I. et al., 2001. Searching for susceptibility genes in schizophrenia. European Neuropsychopharmacology 11 (6), pp.395-398. (10.1016/S0924-977X(01)00116-X)
- Kirov, G. et al. 2001. Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder. Molecular Psychiatry 6 (6), pp.671-677. (10.1038/sj.mp.4000899)
- Payton, A. et al., 2001. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. Neuroscience Letters 105 (5), pp.464-470. (10.1002/ajmg.1407)
2000
- Austin, J. et al., 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5 (5), pp.552-557. (10.1038/sj.mp.4000761)
- Austin, J. et al., 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10 (1), pp.51-54. (10.1097/00041444-200010010-00009)
- Austin, J. et al., 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5 (2), pp.208-212. (10.1038/sj.mp.4000693)
- Bowen, T. et al. 2000. No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder. Bipolar Disorders 2 (4), pp.328-331. (10.1034/j.1399-5618.2000.020406.x)
- Bowen, T. et al. 2000. Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia. Psychiatric Genetics 10 (1), pp.33-37. (10.1097/00041444-200010010-00006)
- Bray, N. J. et al. 2000. No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia. Psychiatric Genetics 10 (2), pp.83-86. (10.1097/00041444-200010020-00005)
- Cardno, A. G. , O'Donovan, M. C. and Owen, M. J. 2000. Genetic risk factors for schizophrenia. International Journal of Mental Health 29 (3), pp.13-38.
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107 (5), pp.488-493. (10.1007/s004390000397)
- Kirov, G. et al. 2000. Automated genotyping of single-nucleotide polymorphisms by extension of fluorescently labelled primers: analysis of individual and pooled DNA samples. Balkan Journal of Medical Genetics 3 , pp.23-28.
- Morris, D. W. et al., 2000. Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q. Human Molecular Genetics 9 (5), pp.843-848. (10.1093/hmg/9.5.843)
- Owen, M. J. , Cardno, A. G. and O'Donovan, M. C. 2000. Psychiatric genetics: back to the future. Molecular Psychiatry 5 (1), pp.22-31. (10.1038/sj.mp.4000702)
- Speight, G. et al., 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5 (3), pp.327-331. (10.1038/sj.mp.4000717)
- Vincent, J. B. et al., 2000. Long repeat tracts at SCA8 in major psychosis. American Journal of Medical Genetics 96 (6), pp.873-876. (10.1002/1096-8628(20001204)96:6<873::AID-AJMG37>3.0.CO;2-9)
1999
- Cardno, A. G. et al., 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45 (12), pp.1592-1596. (10.1016/s0006-3223(99)00033-5)
- Franks, E. et al., 1999. Eleven trinucleotide repeat loci that map to chromosome 12 excluded from involvement in the pathogenesis of bipolar disorder. American Journal of Medical Genetics 88 (1), pp.67-70. (10.1002/(SICI)1096-8628(19990205)88:1<67::AID-AJMG12>3.0.CO;2-#)
- Guy, C. et al. 1999. CTG18.1 and ERDA-1 CAG/CTG repeat size in bipolar disorder. Neurobiology of Disease 6 (4), pp.302-307. (10.1006/nbdi.1999.0249)
- Guy, C. et al. 1999. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88 (1), pp.57-60. (10.1002/(sici)1096-8628(19990205)88:1%3C57::aid-ajmg10%3E3.0.co;2-6)
- Hoogendoorn, B. et al. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104 (1), pp.89-93. (10.1007/s004390050915)
- Jacobsen, N. J. et al., 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8 (9), pp.1631-1636. (10.1093/hmg/8.9.1631)
- Jones, A. C. et al., 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45 (8), pp.1133-1140.
- O'Donovan, M. C. and Owen, M. J. 1999. Candidate-gene association studies of schizophrenia. American Journal of Human Genetics 65 (3), pp.587-592. (10.1086/302560)
- Sakuntabhai, A. et al., 1999. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nature Genetics 21 (3), pp.271-277.
1998
- Bowen, T. et al. 1998. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Molecular Psychiatry 3 (3), pp.266-269. (10.1038/sj.mp.4000400)
- Bowen, T. et al. 1998. Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder. Molecular Psychiatry 3 (1), pp.67-71. (10.1038/sj.mp.4000293)
- Cardno, A. G. et al., 1998. Association between functional psychosis and expanded CAG/CTG repeats is not explained by health stratification [comparative study]. Psychiatric Genetics 8 (1), pp.29-32. (10.1097/00041444-199800810-00005)
- Li, T. et al., 1998. Analysis of CAG/CTG repeat size in Chinese subjects with schizophrenia and bipolar affective disorder using the repeat expansion detection method. Biological psychiatry 44 (11), pp.1160-1165. (10.1016/S0006-3223(97)00492-7)
- O'Donovan, M. C. et al. 1998. Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection. Genomics 52 (1), pp.44-49. (10.1006/geno.1998.5411)
- Oretti, R. G. et al., 1998. Tryptophan pyrrolase gene expression in an alcohol preferring and non-preferring mouse strain. Addiction Biology 3 (1), pp.71-77. (10.1080/13556219872362)
1997
- Craddock, N. J. et al. 1997. Expanded CAG/CTG repeats in bipolar disorder: no correlation with phenotypic measures of illness severity. Biological psychiatry 42 (10), pp.876-881. (10.1016/s0006-3223(96)00516-1)
- Guy, C. et al. 1997. Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder. American Journal of Psychiatry 154 (8), pp.1146-1147.
- Jones, L. et al. 1997. No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia. Molecular Psychiatry 2 (6), pp.478-482. (10.1038/sj.mp.4000297)
- O'Donovan, M. C. and Guy, C. 1997. Bias in the genomic distribution of CAG and CTG trinucleotide repeats. American Journal of Medical Genetics 74 (1), pp.62-64. (10.1002/(SICI)1096-8628(19970221)74:1<62::AID-AJMG14>3.0.CO;2-P)
- Speight, G. et al., 1997. Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia. American Journal of Medical Genetics 74 (2), pp.204-206. (10.1002/(SICI)1096-8628(19970418)74:2<204::AID-AJMG19>3.0.CO;2-M)
1996
- Bowen, T. et al. 1996. Expansion of 50 CAG/CTG repeats excluded in schizophrenia by application of a highly efficient approach using repeat expansion detection and a PCR screening set. American Journal of Human Genetics 59 (4), pp.912-917.
- Cardno, A. G. et al., 1996. Expanded CAG/CTG repeats in schizophrenia. A study of clinical correlates. British Journal of Psychiatry 169 (6), pp.766-771. (10.1192/bjp.169.6.766)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 1996. Introducing Selfcite 2.0--career enhancing software. BMJ 313 (7072), pp.1659-1660. (10.1136/bmj.313.7072.1659)
- O'Donovan, M. C. 1996. Genetics of Mental disorders .1. Theoretical aspects - Mendlewicz,J, Papadimitriou,GN. British Journal of Psychiatry 168 (2), pp.256-256.
- O'Donovan, M. C. et al. 1996. Involvement of expanded trinucleotide repeats in common diseases. The Lancet 348 (9043), pp.1739-1740. (10.1016/s0140-6736(05)65870-9)
- O'Donovan, M. C. et al. 1996. Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychological Medicine -London- 26 (6), pp.1145-1153. (10.1017/s0033291700035868)
- O'Donovan, M. C. and Owen, M. J. 1996. Dynamic mutations and psychiatric genetics. Psychological Medicine 26 (1), pp.1-6. (10.1017/S0033291700033663)
1995
- O'Donovan, M. C. et al. 1995. Expanded CAG repeats in schizophrenia and bipolar disorder [letter]. Nature Genetics 10 (4), pp.380-381. (10.1038/ng0895-380)
1994
- McGuffin, P. et al., 1994. Seminars in psychiatric genetics. Gaskell, Royal College of Psychiatrists.
- Spurlock, G. et al., 1994. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter. Neuropharmacology 33 (3-4), pp.433-440. (10.1016/0028-3908(94)90073-6)
- Thapar, A. et al. 1994. The genetics of mental retardation. The British Journal of Psychiatry 164 (6), pp.747. (10.1192/bjp.164.6.747)
1993
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1993. Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs. Neuroscience Letters 150 (1), pp.25-28. (10.1016/0304-3940(93)90099-7)
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1993. Clozapine and sulpiride up-regulate dopamine D3 receptor mRNA levels. Neuropharmacology 32 (9), pp.901-907. (10.1016/0028-3908(93)90146-T)
- McGuffin, P. and O'Donovan, M. C. 1993. Taking a balanced view on triazolam. British Medical Journal (BMJ) 306 (6893), pp.1690-1691. (10.1136/bmj.306.6893.1690-c)
- O'Donovan, M. C. 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 (6), pp.971-983. (10.1016/0092-8674(93)90585-E)
- O'Donovan, M. C. and McGuffin, P. 1993. Correction: Short acting benzodiazepines. British Medical Journal (BMJ) 306 (6886), pp.1146-1146. (10.1136/bmj.306.6886.1146)
- O'Donovan, M. C. and McGuffin, P. 1993. Short acting benzodiazepines.. British Medical Journal (BMJ) 306 (6883), pp.945-946. (10.1136/bmj.306.6883.945)
1992
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1992. Changes in dopa decarboxylase mRNA but not tyrosine hydroxylase mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 108 (1-2), pp.98-102. (10.1007/BF02245292)
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1992. Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 106 (4), pp.479-483. (10.1007/BF02244818)
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1992. Lack of effect of chronic antipsychotic treatment on dopamine D5 receptor mRNA level. European Neuropsychopharmacology 2 (4), pp.405-409. (10.1016/0924-977X(92)90002-P)
- O'Donovan, M. C. , Buckland, P. R. and McGuffin, P. 1992. The expression of neuroreceptor genes and benzodiazepine tolerance.. Clinical Neuropharmacology 15 (Supp1), pp.218A-219A. (10.1097/00002826-199201001-00114)
- O'Donovan, M. C. , Buckland, P. R. and McGuffin, P. 1992. Levels of GABAa receptor subunit mRNA in rat brain following flurazepam treatment. Journal of Psychopharmacology 6 (3), pp.364-369. (10.1177/026988119200600304)
- O'Donovan, M. C. et al. 1992. Bi-directional changes in the levels of messenger RNAs encoding γ-aminobutyric acidA receptor α subunits after flurazepam treatment. European Journal of Pharmacology: Molecular Pharmacology 226 (4), pp.335-341. (10.1016/0922-4106(92)90051-V)
- O'Donovan, M. C. and Owen, M. J. 1992. Advances and Retreats in the Molecular Genetics of Major Mental Illness. Annals of Medicine 24 (3), pp.171-177. (10.3109/07853899209147816)
1991
- Havard, H. L. et al., 1991. The effects of antidepressant drugs on kainate receptor mRNA levels. Neuropharmacology 30 (6), pp.675-677. (10.1016/0028-3908(91)90090-X)
- O'Donovan, M. C. and Buckland, P. R. 1991. Simultaneous quantification of several mRNA species by solution hybridisation with oligonucleotides. Nucleic Acids Research 19 (12), pp.3466. (10.1093/nar/19.12.3466)
- O'Donovan, M. C. and McGuffin, P. 1991. Growing points in psychiatric genetics. British Journal of Hospital Medicine 46 (6), pp.359-360.
1989
- Espie, C. et al., 1989. The mentally handicapped person with epilepsy: a comparative study investigating psychosocial functioning.. Journal of Mental Health Defiency Research 33 (2), pp.123-135.
Articles
- Aberg, K. A. et al., 2013. A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry 70 (6), pp.573-581. (10.1001/jamapsychiatry.2013.288)
- Abraham, R. et al., 2008. A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Medical Genomics 1 (1) 44. (10.1186/1755-8794-1-44)
- Abraham, R. et al., 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109 (6), pp.646-652. (10.1007/s00439-001-0614-1)
- Abraham, R. A. et al. 2009. An association study of common variation at theMAPTlocus with late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (8), pp.1152-1155. (10.1002/ajmg.b.30951)
- Allison, D. B. et al., 2010. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genetics 6 (9) e1001097. (10.1371/journal.pgen.1001097)
- Andreassen, O. A. et al., 2014. Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Molecular Psychiatry 20 (2), pp.207. (10.1038/mp.2013.195)
- Andreassen, O. A. et al., 2015. Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLoS Genetics 11 (11) e1005544. (10.1371/journal.pgen.1005544)
- Andreassen, O. et al., 2013. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. American Journal of Human Genetics 92 (2), pp.197-209. (10.1016/j.ajhg.2013.01.001)
- Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7 (5), pp.493-502. (10.1038/sj.mp.4001003)
- Arloth, J. et al., 2015. Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders. Neuron 86 (5), pp.1189-1202. (10.1016/j.neuron.2015.05.034)
- Austin, J. et al., 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5 (5), pp.552-557. (10.1038/sj.mp.4000761)
- Austin, J. et al., 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10 (1), pp.51-54. (10.1097/00041444-200010010-00009)
- Austin, J. et al., 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5 (2), pp.208-212. (10.1038/sj.mp.4000693)
- Ayalew, M. et al., 2012. Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Molecular Psychiatry 17 (9), pp.887-905. (10.1038/mp.2012.37)
- Bacanu, S. et al., 2014. Functional SNPs are enriched for schizophrenia association signals [Letter]. Molecular Psychiatry 19 (3), pp.276-277. (10.1038/mp.2013.33)
- Barton, A. et al., 2008. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Human Molecular Genetics 17 (15), pp.2274-2279. (10.1093/hmg/ddn128)
- Barton, A. et al., 2008. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics 40 (10), pp.1156-1159. (10.1038/ng.218)
- Betcheva, E. T. et al., 2009. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. Journal of Human Genetics 54 (2), pp.98-107. (10.1038/jhg.2008.14)
- Bigdeli, T. B. et al., 2016. Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171 (2), pp.276-289. (10.1002/ajmg.b.32402)
- Blake, D. J. et al., 2010. TCF4, Schizophrenia, and Pitt-Hopkins Syndrome. Schizophrenia Bulletin 36 (3), pp.443-447. (10.1093/schbul/sbq035)
- Bowen, T. et al. 2000. No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder. Bipolar Disorders 2 (4), pp.328-331. (10.1034/j.1399-5618.2000.020406.x)
- Bowen, T. et al. 2000. Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia. Psychiatric Genetics 10 (1), pp.33-37. (10.1097/00041444-200010010-00006)
- Bowen, T. et al. 1998. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Molecular Psychiatry 3 (3), pp.266-269. (10.1038/sj.mp.4000400)
- Bowen, T. et al. 1996. Expansion of 50 CAG/CTG repeats excluded in schizophrenia by application of a highly efficient approach using repeat expansion detection and a PCR screening set. American Journal of Human Genetics 59 (4), pp.912-917.
- Bowen, T. et al. 1998. Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder. Molecular Psychiatry 3 (1), pp.67-71. (10.1038/sj.mp.4000293)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6 (3), pp.259-260. (10.1038/sj.mp.4000128)
- Bray, N. B. et al. 2003. Cis-acting variation in the expression of a high proportion of genes in human brain. Human Genetics 113 (2), pp.149-153. (10.1007/s00439-003-0956-y)
- Bray, N. J. et al. 2004. The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Molecular Psychiatry 9 (1), pp.109-114. (10.1038/sj.mp.4001366)
- Bray, N. J. et al. 2002. Detection of cis-acting polymorphisms and epigenetic modification affecting gene expression [Conference Abstracts]. American Journal of Medical Genetics 114 (7), pp.750-750. (10.1002/ajmg.10971)
- Bray, N. J. et al. 2003. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. The American Journal of Human Genetics 73 (1), pp.152-161. (10.1086/376578)
- Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17 (8), pp.1169-1174. (10.1093/hmg/ddn006)
- Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B (7), pp.723-724.
- Bray, N. J. et al. 2004. Allelic expression of APOE in brain [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.61-61.
- Bray, N. J. et al. 2004. P4-101 Allelic expression of APOE in brain [Conference Abstract]. Neurobiology of Aging 25 , pp.S503-S503. (10.1016/S0197-4580(04)81659-2)
- Bray, N. J. et al. 2004. Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes. Human Molecular Genetics 13 (22), pp.2885-2892. (10.1093/hmg/ddh299)
- Bray, N. J. et al. 2002. Screening the human protocadherin 8 (PCDH8) gene in schizophrenia. Genes, Brain and Behavior 1 (3), pp.187-191. (10.1034/j.1601-183X.2002.10307.x)
- Bray, N. J. et al. 2002. Screening the protocadherin 8 (PCDH8) gene in schizophrenia [Conference Abstract]. American Journal of Medical Genetics 114 (7), pp.844-844.
- Bray, N. J. and O'Donovan, M. C. 2006. Investigating cis-acting regulatory variation using assays of relative allelic expression. Psychiatric Genetics 16 (4), pp.173-177. (10.1097/01.ypg.0000218612.35139.84)
- Bray, N. J. et al. 2004. Allelic variation in the expression of neuropsychiatric candidate genes [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.25-25.
- Bray, N. J. et al. 2005. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Human Molecular Genetics 14 (14), pp.1947-1954. (10.1093/hmg/ddi199)
- Bray, N. J. et al. 2000. No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia. Psychiatric Genetics 10 (2), pp.83-86. (10.1097/00041444-200010020-00005)
- Breuer, R. et al., 2010. Independent evidence for the selective influence of GABAA receptors on one component of the bipolar disorder phenotype [letter]. Molecular Psychiatry 16 (6), pp.587-589. (10.1038/mp.2010.67)
- Bridges, M. et al., 2011. Genetic classification of populations using supervised learning. PLoS ONE 6 (5) e14802. (10.1371/journal.pone.0014802)
- Buckland, P. R. et al. 2003. A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expression 11 (5), pp.233-239. (10.3727/000000003783992225)
- Buckland, P. R. et al. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26 (3), pp.214-223. (10.1002/humu.20207)
- Buckland, P. R. et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690 (3), pp.238-249.
- Buckland, P. R. et al. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162 (3), pp.613-615. (10.1176/appi.ajp.162.3.613)
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1993. Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs. Neuroscience Letters 150 (1), pp.25-28. (10.1016/0304-3940(93)90099-7)
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1992. Changes in dopa decarboxylase mRNA but not tyrosine hydroxylase mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 108 (1-2), pp.98-102. (10.1007/BF02245292)
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1992. Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 106 (4), pp.479-483. (10.1007/BF02244818)
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1993. Clozapine and sulpiride up-regulate dopamine D3 receptor mRNA levels. Neuropharmacology 32 (9), pp.901-907. (10.1016/0028-3908(93)90146-T)
- Buckland, P. R. , O'Donovan, M. C. and McGuffin, P. 1992. Lack of effect of chronic antipsychotic treatment on dopamine D5 receptor mRNA level. European Neuropsychopharmacology 2 (4), pp.405-409. (10.1016/0924-977X(92)90002-P)
- Burton, P. R. et al., 2007. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics 39 (11), pp.1329-1337. (10.1038/ng.2007.17)
- Busby, V. et al., 2004. Alpha-T-Catenin Is Expressed in Human Brain and Interacts With the Wnt Signaling Pathway But Is Not Responsible for Linkage to Chromosome 10 in Alzheimer's Disease. Neuromolecular Medicine 5 (2), pp.133-146. (10.1385/NMM:5:2:133)
- Buxbaum, J. D. et al., 2008. Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Molecular psychiatry 13 , pp.162-172. (10.1038/sj.mp.4001991)
- Cardno, A. G. et al., 2011. A genomewide linkage study of age at onset in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B (8), pp.929-940. (10.1002/ajmg.1404)
- Cardno, A. G. et al., 1998. Association between functional psychosis and expanded CAG/CTG repeats is not explained by health stratification [comparative study]. Psychiatric Genetics 8 (1), pp.29-32. (10.1097/00041444-199800810-00005)
- Cardno, A. G. et al., 1996. Expanded CAG/CTG repeats in schizophrenia. A study of clinical correlates. British Journal of Psychiatry 169 (6), pp.766-771. (10.1192/bjp.169.6.766)
- Cardno, A. G. , O'Donovan, M. C. and Owen, M. J. 2000. Genetic risk factors for schizophrenia. International Journal of Mental Health 29 (3), pp.13-38.
- Cardno, A. G. et al., 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45 (12), pp.1592-1596. (10.1016/s0006-3223(99)00033-5)
- Carroll, L. S. et al., 2016. Mutation screening of SCN2A in schizophrenia and identification of a novel loss-of-function mutation. Psychiatric Genetics 26 (2), pp.60-65. (10.1097/YPG.0000000000000110)
- Carroll, L. S. et al. 2009. Evidence that putative ADHD low risk alleles atSNAP25may increase the risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (7), pp.893-899. (10.1002/ajmg.b.30915)
- Carroll, L. S. et al. 2011. Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (7), pp.844-849. (10.1002/ajmg.b.31231)
- Carroll, L. S. et al. 2010. Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha. Molecular Psychiatry 15 (11), pp.1101-1111. (10.1038/mp.2009.96)
- Caspi, A. et al., 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 65 (2), pp.203-210. (10.1001/archgenpsychiatry.2007.24)
- Chapman, J. et al., 2013. A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk. Human Molecular Genetics 22 (4), pp.816-824. (10.1093/hmg/dds476)
- Chapman, R. M. et al., 2012. Inducible over-expression and siRNA mediated knock-down of the schizophrenia susceptibility gene ZNF804A: Detection of altered gene expression and splicing using whole genome exon arrays. International Journal of Developmental Neuroscience 30 (8), pp.673-673. (10.1016/j.ijdevneu.2012.10.011)
- Chapuis, J. et al., 2013. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology [Article]. Molecular Psychiatry 18 (11), pp.1225-1234. (10.1038/mp.2013.1)
- Chen, J. et al., 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131 (1-3), pp.43-51.
- Chen, X. et al., 2010. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Molecular Psychiatry 16 (11), pp.1117-1129. (10.1038/mp.2010.96)
- Cichon, S. et al., 2004. Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nature Genetics 36 (8), pp.783-784. (10.1038/ng0804-783)
- Cichon, S. et al., 2011. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. American Journal of Human Genetics 88 (3), pp.372-381. (10.1016/j.ajhg.2011.01.017)
- Coleman, S. L. et al. 2002. Experimental analysis of the annotation of promoters in the public database. Human Molecular Genetics 11 (16), pp.1817-1821. (10.1093/hmg/11.16.1817)
- Coleman, S. L. et al. 2002. Streamlined approach to functional analysis of promoter-region polymorphisms. Biotechniques 33 (2), pp.412-418.
- Collins, A. L. et al., 2012. Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. Psychological Medicine 42 (3), pp.607-616. (10.1017/S0033291711001607)
- Cooper, J. D. et al., 2012. Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics 21 (23), pp.5202-5208. (10.1093/hmg/dds357)
- Cope, N. A. et al., 2005. No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia. Molecular Psychiatry 10 (3), pp.237-238. (10.1038/sj.mp.4001596)
- Cope, N. A. et al., 2005. Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. American Journal of Human Genetics 76 (4), pp.581-591. (10.1086/429131)
- Corvin, A. and O'Donovan, M. C. 2016. Psychiatric genetics: what's new in 2015?. The Lancet Psychiatry 3 (1), pp.10-12. (10.1016/S2215-0366(15)00571-4)
- Craddock, N. J. et al. 2008. Authors' reply. The British Journal of Psychiatry 193 (6), pp.517. (10.1192/bjp.193.6.517)
- Craddock, N. J. et al. 2008. Wake-up call for British psychiatry. British Journal of Psychiatry 193 (1), pp.6-9. (10.1192/bjp.bp.108.053561)
- Craddock, N. J. et al. 2008. Wake up call: Response from authors [eLetter]. British Journal of Psychiatry
- Craddock, N. J. et al. 2014. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophrenia Bulletin 40 (4), pp.729-736. (10.1093/schbul/sbu069)
- Craddock, N. J. et al. 2010. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 464 (7289), pp.713-720. (10.1038/nature08979)
- Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Molecular Psychiatry 15 (2), pp.146-153. (10.1038/mp.2008.66)
- Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype [Corrigendum]. Molecular Psychiatry 15 (11), pp.1121-1121. (10.1038/mp.2010.62)
- Craddock, N. J. et al. 1997. Expanded CAG/CTG repeats in bipolar disorder: no correlation with phenotypic measures of illness severity. Biological psychiatry 42 (10), pp.876-881. (10.1016/s0006-3223(96)00516-1)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2005. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophrenia Bulletin 32 (1), pp.9-16. (10.1093/schbul/sbj033)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2008. Genome-wide association studies in psychiatry: lessons from early studies of non-psychiatric and psychiatric phenotypes [Guest Editorial]. Molecular Psychiatry 13 (7), pp.649-653. (10.1038/mp.2008.45)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 1996. Introducing Selfcite 2.0--career enhancing software. BMJ 313 (7072), pp.1659-1660. (10.1136/bmj.313.7072.1659)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2007. Phenotypic and genetic complexity of psychosis Invited commentary on ... Schizophrenia: a common disease caused by multiple rare alleles. British Journal of Psychiatry 190 (3), pp.200-203. (10.1192/bjp.bp.106.033761)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2009. Psychosis genetics: modeling the relationship between Schizophrenia, Bipolar Disorder, and Mixed (or "Schizoaffective") Psychoses. Schizophrenia Bulletin 35 (3), pp.482-490. (10.1093/schbul/sbp020)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2007. Symptom dimensions and the Kraepelinian dichotomy. British Journal of Psychiatry 190 (4), pp.361. (10.1192/bjp.190.4.361)
- Craddock, N. J. , O'Donovan, M. C. and Owen, M. J. 2005. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. Journal of Medical Genetics 42 (3), pp.193-204. (10.1136/jmg.2005.030718)
- Craddock, N. J. , Owen, M. J. and O'Donovan, M. C. 2006. The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons. Molecular Psychiatry 11 (5), pp.446-458. (10.1038/sj.mp.4001808)
- Crawford, A. A. et al., 2014. Adverse effects from antidepressant treatment: randomised controlled trial of 601 depressed individuals. Psychopharmacology 231 (15), pp.2921-2931. (10.1007/s00213-014-3467-8)
- De Rubeis, S. et al., 2014. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515 , pp.209-215. (10.1038/nature13772)
- de Candia, T. et al., 2013. Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. American Journal of Human Genetics 93 (3), pp.463-470. (10.1016/j.ajhg.2013.07.007)
- Derks, E. M. et al., 2012. Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis. PLoS ONE 7 (6) e37852. (10.1371/journal.pone.0037852)
- Desikan, R. S. et al., 2015. Genetic overlap between Alzheimer's Disease and Parkinson's Disease at the MAPT locus. Molecular Psychiatry 20 (12), pp.1588-1595. (10.1038/mp.2015.6)
- Desikan, R. S. et al., 2015. Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer Disease. Circulation 131 (23), pp.2061-2069. (10.1161/CIRCULATIONAHA.115.015489)
- Doherty, J. L. , O'Donovan, M. C. and Owen, M. J. 2012. Recent genomic advances in schizophrenia. Clinical Genetics 81 (2), pp.103-109. (10.1111/j.1399-0004.2011.01773.x)
- Domschke, K. et al., 2007. Meta-analysis of COMT val158met in panic disorder: Ethnic heterogeneity and gender specificity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (5), pp.667-673. (10.1002/ajmg.b.30494)
- Donohoe, G. et al., 2013. Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253. Genes, Brain and Behavior 12 (2), pp.203-209. (10.1111/gbb.12016)
- Donohoe, G. et al., 2011. A neuropsychological investigation of the genome wide associated schizophrenia risk variant NRGN rs12807809 [Letter]. Schizophrenia Research 125 (2-3), pp.304-306. (10.1016/j.schres.2010.10.019)
- Donohoe, G. et al., 2009. Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects. Archives of General Psychiatry 66 (10), pp.1045-1054. (10.1001/archgenpsychiatry.2009.139)
- Dwyer, S. L. et al. 2009. Mutation screening of the DTNBP1 exonic sequence in 669 schizophrenics and 710 controls using high-resolution melting analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (3), pp.766-774. (10.1002/ajmg.b.31045)
- Dwyer, S. L. et al. 2010. No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (8), pp.1411-1416. (10.1002/ajmg.b.31117)
- Dwyer, S. L. et al. 2011. Investigation of rare non-synonymous variants at ABCA13 in schizophrenia and bipolar disorder [letter]. Molecular Psychiatry 16 (8), pp.790-791. (10.1038/mp.2011.2)
- Escott-Price, V. et al. 2014. Gene-wide analysis detects two new susceptibility genes for Alzheimer's Disease. PLoS ONE 9 (6) e94661. (10.1371/journal.pone.0094661)
- Escott-Price, V. et al. 2006. Effects of differential genotyping error rate on the Type 1 error probability of case-control studies. Human heredity 61 (1), pp.55-64. (10.1159/000092553)
- Escott-Price, V. et al. 2009. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Molecular Psychiatry 14 (3), pp.252-260. (10.1038/mp.2008.133)
- Escott-Price, V. et al. 2011. An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction. Biological Psychiatry 70 (2), pp.198-203. (10.1016/j.biopsych.2011.01.034)
- Escott-Price, V. et al. 2015. No evidence for enrichment in schizophrenia for common allelic associations at imprinted loci. PLoS ONE 10 (12), pp.-. e0144172. (10.1371/journal.pone.0144172)
- Escott-Price, V. et al. 2005. Streamlined analysis of pooled genotype data in SNP-based association studies. Genetic Epidemiology 28 (3), pp.273-282. (10.1002/gepi.20062)
- Escott-Price, V. and O'Donovan, M. C. 2007. Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation. Human Heredity 64 (1), pp.63-73. (10.1159/000101424)
- Escott-Price, V. et al. 2011. Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study. Genetic Epidemiology 35 (8), pp.861-866. (10.1002/gepi.20636)
- Escott-Price, V. et al. 2012. Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis. European Journal of Human Genetics 20 (8), pp.890-896. (10.1038/ejhg.2012.8)
- Escott-Price, V. et al. 2010. Genetic differences between five European populations. Human Heredity 70 (2), pp.141-149. (10.1159/000313854)
- Espie, C. et al., 1989. The mentally handicapped person with epilepsy: a comparative study investigating psychosocial functioning.. Journal of Mental Health Defiency Research 33 (2), pp.123-135.
- Eyre, S. et al., 2012. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics 44 (12), pp.1336-1340. (10.1038/ng.2462)
- Farrell, M. S. et al., 2015. Evaluating historical candidate genes for schizophrenia. Molecular Psychiatry 20 (5), pp.555-562. (10.1038/mp.2015.16)
- Fekadu, A. et al., 2008. Validity of the concept of minor depression in a developing country setting. Journal of Nervous and Mental Disease 196 (1), pp.22-28. (10.1097/NMD.0b013e31815fa4d4)
- Ferreira, M. A. R. et al., 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 40 (9), pp.1056-1058. (10.1038/ng.209)
- Fisher, S. A. et al., 2008. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics 40 (6), pp.710-712. (10.1038/ng.145)
- Fowler, T. A. et al., 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.98-98. (10.1002/ajmg.b.30101)
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19 (6), pp.312-319. (10.1097/YPG.0b013e3283328df4)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194 (1), pp.62-67. (10.1192/bjp.bp.107.046870)
- Franks, E. et al., 1999. Eleven trinucleotide repeat loci that map to chromosome 12 excluded from involvement in the pathogenesis of bipolar disorder. American Journal of Medical Genetics 88 (1), pp.67-70. (10.1002/(SICI)1096-8628(19990205)88:1<67::AID-AJMG12>3.0.CO;2-#)
- Fromer, M. et al., 2012. Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth. American Journal of Human Genetics 91 (4), pp.597-607. (10.1016/j.ajhg.2012.08.005)
- Fromer, M. et al., 2014. De novo mutations in schizophrenia implicate synaptic networks. Nature 506 , pp.179-184. (10.1038/nature12929)
- Georgieva, L. et al. 2008. Support for Neuregulin 1 as a susceptibility gene for Bipolar disorder and schizophrenia. Biological psychiatry 64 (5), pp.419-427. (10.1016/j.biopsych.2008.03.025)
- Georgieva, L. et al. 2006. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 103 (33), pp.12469-12474. (10.1073/pnas.0603029103)
- Georgieva, L. et al. 2014. De novo CNVs in bipolar affective disorder and schizophrenia. Human Molecular Genetics 23 (24), pp.6677-6683. (10.1093/hmg/ddu379)
- Gerrish, A. et al. 2012. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's Disease. Journal of Alzheimer's Disease 28 (2), pp.377-387. (10.3233/JAD-2011-110824)
- Gerrish, A. et al. 2009. An examination of MUTED as a schizophrenia susceptibility gene [Letter]. Schizophrenia Research 107 (1), pp.110-111. (10.1016/j.schres.2008.08.011)
- Gibson, G. et al., 2013. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genetics 9 (4) e1003449. (10.1371/journal.pgen.1003449)
- Glaser, B. et al., 2005. Identification of a potential Bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. Molecular Psychiatry 10 (10), pp.920-927. (10.1038/sj.mp.4001689)
- Glaser, B. et al., 2005. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. Biological psychiatry 58 (1), pp.78-80.
- Glaser, B. et al., 2006. Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility. Schizophrenia Research 87 (1-3), pp.21. (10.1016/j.schres.2006.05.024)
- Gough, S. C. and O'Donovan, M. C. 2005. Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?. Journal of Psychopharmacology 19 (6), pp.47-55. (10.1177/0269881105058380)
- Green, E. et al., 2005. Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease. American Journal of Psychiatry 162 (1), pp.35-42. (10.1176/appi.ajp.162.1.35)
- Green, E. K. et al., 2006. Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation. Molecular Psychiatry 11 (9), pp.798-799. (10.1038/sj.mp.4001853)
- Green, E. K. et al., 2015. Copy number variation in bipolar disorder. Molecular Psychiatry 21 (1), pp.89-93. (10.1038/mp.2014.174)
- Green, E. K. et al., 2006. Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK. British Journal of Psychiatry 188 (1), pp.21-25. (10.1192/bjp.bp.105.009969)
- Green, E. K. et al. 2010. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (7), pp.1347-1349. (10.1002/ajmg.b.31108)
- Green, E. K. et al. 2013. Association at SYNE1 in both bipolar disorder and recurrent major depression. Molecular Psychiatry 18 , pp.614-617. (10.1038/mp.2012.48)
- Green, E. K. et al. 2010. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Molecular Psychiatry 15 (10), pp.1016-1022. (10.1038/mp.2009.49)
- Green, E. K. et al. 2009. P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (8), pp.1063-1069. (10.1002/ajmg.b.30931)
- Green, E. K. et al. 2011. DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B (4), pp.490-492. (10.1002/ajmg.b.31187)
- Green, E. K. et al. 2013. Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. Molecular Psychiatry 18 (12), pp.1302-1307. (10.1038/mp.2012.142)
- Green, E. K. et al. 2005. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Archives of general psychiatry 62 (6), pp.642-648. (10.1001/archpsyc.62.6.642)
- Grozeva, D. et al. 2012. Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia. Schizophrenia Research 135 (1-3), pp.1-7. (10.1016/j.schres.2011.11.004)
- Grozeva, D. et al. 2013. Reduced burden of very large and rare CNVs in bipolar affective disorder. Bipolar Disorders 15 (8), pp.893-8. (10.1111/bdi.12125)
- Grozeva, D. et al. 2010. Rare copy number variants: A point of rarity in genetic risk for bipolar disorder and schizophrenia. Archives of General Psychiatry 67 (4), pp.318-327. (10.1001/archgenpsychiatry.2010.25)
- Grupe, A. et al., 2007. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics 16 (8), pp.865-873. (10.1093/hmg/ddm031)
- Grupe, A. et al., 2006. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. The American Journal of Human Genetics 78 (1), pp.78-88.
- Guha, S. et al., 2013. Implication of a rare deletion at distal 16p11.2 in schizophrenia. JAMA Psychiatry 70 (3), pp.253-260. (10.1001/2013.jamapsychiatry.71)
- Gunnell, D. et al., 2007. IGF1, growth pathway polymorphisms and schizophrenia: A pooling study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (1), pp.117-120. (10.1002/ajmg.b.30396)
- Gusev, A. et al., 2014. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. American Journal of Human Genetics 95 (5), pp.535-552. (10.1016/j.ajhg.2014.10.004)
- Guy, C. et al. 1997. Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder. American Journal of Psychiatry 154 (8), pp.1146-1147.
- Guy, C. et al. 1999. CTG18.1 and ERDA-1 CAG/CTG repeat size in bipolar disorder. Neurobiology of Disease 6 (4), pp.302-307. (10.1006/nbdi.1999.0249)
- Guy, C. et al. 1999. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88 (1), pp.57-60. (10.1002/(sici)1096-8628(19990205)88:1%3C57::aid-ajmg10%3E3.0.co;2-6)
- Guy, C. et al. 2004. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 14 (1), pp.45-51. (10.1097/00008571-200401000-00005)
- Hall, J. et al. 2015. Genetic risk for schizophrenia: convergence on synaptic pathways Involved in plasticity. Biological Psychiatry 77 (1), pp.52-68. (10.1016/j.biopsych.2014.07.011)
- Hamilton, G. et al., 2012. The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B (6), pp.696-709. (10.1002/ajmg.b.32073)
- Hamilton, G. et al., 2012. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiology of Aging 33 (8) 1848.e1. (10.1016/j.neurobiolaging.2012.02.005)
- Hamilton, G. et al., 2007. Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (4), pp.508-516. (10.1002/ajmg.b.30503)
- Hamilton, G. et al., 2007. Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease. Neuromolecular Medicine 9 (4), pp.331-334. (10.1007/s12017-007-8013-y)
- Hamilton, G. et al., 2006. Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Neuroscience Letters 401 (1-2), pp.77-80. (10.1016/j.neulet.2006.03.021)
- Hamshere, M. L. et al. 2005. Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Archives of general psychiatry 62 (10), pp.1081-1088. (10.1001/archpsyc.62.10.1081)
- Hamshere, M. L. et al. 2009. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. British Journal of Psychiatry 195 (1), pp.23-29. (10.1192/bjp.bp.108.061424)
- Hamshere, M. L. et al. 2007. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics Advanc , pp.1-34. (10.1093/hmg/ddm224)
- Hamshere, M. L. et al. 2011. Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (8), pp.929-940. (10.1002/ajmg.b.31240)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170 (8), pp.909-916. (10.1176/appi.ajp.2013.12081129)
- Hamshere, M. L. et al. 2011. Polygenic dissection of the bipolar phenotype. British Journal of Psychiatry 198 (4), pp.284-288. (10.1192/bjp.bp.110.087866)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203 (2), pp.107-111. (10.1192/bjp.bp.112.117432)
- Hamshere, M. L. et al. 2013. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Molecular Psychiatry 18 (6), pp.708-712. (10.1038/mp.2012.67)
- Hamshere, M. L. et al. 2006. Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes. Journal of Medical Genetics 43 (7), pp.563-567. (10.1136/jmg.2005.035345)
- Hannon, E. et al., 2016. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nature Neuroscience 19 (1), pp.48-54. (10.1038/nn.4182)
- Hansen, T. et al., 2011. At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia. Biological Psychiatry 70 (1), pp.59-63. (10.1016/j.biopsych.2011.01.031)
- Harold, D. et al., 2006. Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. Molecular Psychiatry 11 (12), pp.1085-91. (10.1038/sj.mp.4001904)
- Harold, D. et al. 2009. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Corrigendum]. Nature Genetics 41 (10), pp.1156. (10.1038/ng1009-1156d)
- Harold, D. et al. 2009. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Letter]. Nature Genetics 41 (10), pp.1088-1093. (10.1038/ng.440)
- Harold, D. et al. 2007. Interaction between theADAM12 andSH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (4), pp.448-452. (10.1002/ajmg.b.30456)
- Harold, D. et al. 2006. A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacogenetics and genomics 16 (2), pp.75-77.
- Harold, D. et al. 2003. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Human Genetics 113 (3), pp.258-267. (10.1007/s00439-003-0960-2)
- Havard, H. L. et al., 1991. The effects of antidepressant drugs on kainate receptor mRNA levels. Neuropharmacology 30 (6), pp.675-677. (10.1016/0028-3908(91)90090-X)
- Håvik, B. et al., 2012. DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. PLoS ONE 7 (4), pp.e35424. (10.1371/journal.pone.0035424)
- Hawi, Z. et al., 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Molecular Psychiatry 7 (7), pp.718-725. (10.1038/sj.mp.4001048)
- Hayesmoore, J. B. G. et al. 2009. The effect of age and the H1c MAPT haplotype on MAPT expression in human brain. Neurobiology of Aging 30 (10), pp.1652-1656. (10.1016/j.neurobiolaging.2007.12.017)
- Hayesmoore, J. B. et al. 2008. DISC1mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (7), pp.1065-1069. (10.1002/ajmg.b.30715)
- Hinney, A. et al., 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (8), pp.888-897. (10.1002/ajmg.b.31246)
- Hodgson, K. et al., 2014. Genetic predictors of antidepressant side effects: A grouped candidate gene approach in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study. Journal of Psychopharmacology 28 (2), pp.142-150. (10.1177/0269881113517957)
- Hollingworth, P. et al., 2007. Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (7), pp.841-848. (10.1002/ajmg.b.30515)
- Hollingworth, P. et al. 2011. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics 43 (5), pp.429-435. (10.1038/ng.803)
- Hollingworth, P. et al. 2012. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Molecular Psychiatry 17 (12), pp.1316-1327. (10.1038/mp.2011.125)
- Holmans, P. A. et al. 2009. Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. American Journal of Human Genetics 85 (1), pp.13-24. (10.1016/j.ajhg.2009.05.011)
- Holmans, P. A. et al. 2005. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B (1), pp.24-32. (10.1002/ajmg.b.30114)
- Holmans, P. A. et al. 2009. Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms. Molecular Psychiatry 14 (8), pp.786-795. (10.1038/mp.2009.11)
- Hoogendoorn, B. et al. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12 (18), pp.2249-2254. (10.1093/hmg/ddg246)
- Hoogendoorn, B. et al. 2004. Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation 24 (1), pp.35-42. (10.1002/humu.20061)
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107 (5), pp.488-493. (10.1007/s004390000397)
- Hoogendoorn, B. et al. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104 (1), pp.89-93. (10.1007/s004390050915)
- Hosp, F. et al., 2015. Quantitative interaction proteomics of neurodegenerative disease proteins. Cell Reports 11 (7), pp.1134-46. (10.1016/j.celrep.2015.04.030)
- Huang, J. et al., 2015. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nature Communications 6 8111. (10.1038/ncomms9111)
- Hubbard, L. et al. 2016. Evidence of common genetic overlap between schizophrenia and cognition. Schizophrenia Bulletin 42 (3), pp.832-842. (10.1093/schbul/sbv168)
- Hudson, G. et al., 2012. No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology 78 (14), pp.1038-1042. (10.1212/WNL.0b013e31824e8f1d)
- Huezo-Diaz, P. et al., 2004. An association study of the neurotensin receptor gene with schizophrenia and clozapine response. Schizophrenia Research 66 (2-3), pp.193-195. (10.1016/S0920-9964(03)00128-2)
- Ikeda, M. et al., 2011. Genome-Wide Association Study of Schizophrenia in a Japanese Population. Biological Psychiatry 69 (5), pp.472-478. (10.1016/j.biopsych.2010.07.010)
- Ikeda, M. et al. 2010. Copy number variation in schizophrenia in the Japanese population. Biological Psychiatry 67 (3), pp.283-286. (10.1016/j.biopsych.2009.08.034)
- Ikeda, M. et al. 2010. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biological psychiatry 67 (3), pp.263-269. (10.1016/j.biopsych.2009.08.030)
- Ikeda, M. et al. 2010. Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (4), pp.980-982. (10.1002/ajmg.b.31060)
- Ikeda, M. et al., 2008. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics 9 (10), pp.1437-1443. (10.2217/14622416.9.10.1437)
- Ingason, A. et al., 2009. A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Human Molecular Genetics 19 (7), pp.1379-1386. (10.1093/hmg/ddq009)
- Ingason, A. et al., 2015. Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case?control sample of schizophrenia. Translational Psychiatry 5 (10) e656. (10.1038/tp.2015.151)
- Ingason, A. et al., 2011. Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness. American Journal of Psychiatry 168 (4), pp.408-417. (10.1176/appi.ajp.2010.09111660)
- Ivanov, D. et al. 2003. Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis: Molecular genetic study. The British Journal of Psychiatry 183 (5), pp.409-413. (10.1192/bjp.183.5.409)
- Jacobsen, N. J. et al., 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8 (9), pp.1631-1636. (10.1093/hmg/8.9.1631)
- Jacobsen, N. J. O. et al., 2001. Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder. Molecular Psychiatry 6 (1), pp.92-97. (10.1038/sj.mp.4000774)
- Jacobsen, N. J. O. et al., 2001. CUX2, a potential regulator of NCAM expression: Genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder. American Journal of Medical Genetics 105 (3), pp.295-300. (10.1002/ajmg.1325)
- Jia, P. et al., 2012. A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. Journal of Medical Genetics 49 (2), pp.96-103. (10.1136/jmedgenet-2011-100397)
- Jia, P. et al., 2012. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Computational Biology 8 (7) e1002587. (10.1371/journal.pcbi.1002587)
- Jones, A. C. et al., 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45 (8), pp.1133-1140.
- Jones, L. et al. 2010. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS ONE 5 (11) e13950. (10.1371/journal.pone.0013950)
- Jones, L. et al. 2015. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's and Dementia 11 (6), pp.658-671. (10.1016/j.jalz.2014.05.1757)
- Jones, L. et al. 1997. No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia. Molecular Psychiatry 2 (6), pp.478-482. (10.1038/sj.mp.4000297)
- Jostins, L. et al., 2012. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491 (7422), pp.119-124. (10.1038/nature11582)
- Jun, G. et al., 2016. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry 21 , pp.108-117. (10.1038/mp.2015.23)
- Jurewicz, I. et al., 2001. Searching for susceptibility genes in schizophrenia. European Neuropsychopharmacology 11 (6), pp.395-398. (10.1016/S0924-977X(01)00116-X)
- Kavanagh, D. et al., 2015. Schizophrenia genetics: emerging themes for a complex disorder. Molecular Psychiatry 20 (1), pp.72-76. (10.1038/mp.2014.148)
- Kavanagh, D. et al., 2013. The ENCODE project: implications for psychiatric genetics. Molecular Psychiatry 18 (5), pp.540-542. (10.1038/mp.2013.13)
- Keller, M. C. et al., 2012. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. Plos Genetics 8 (4) e1002656. (10.1371/journal.pgen.1002656)
- Kendler, K. S. and O'Donovan, M. C. 2014. A breakthrough in schizophrenia genetics. JAMA Psychiatry 71 (12), pp.1319-1320. (10.1001/jamapsychiatry.2014.1776)
- Kent, L. et al., 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10 (10), pp.939-943. (10.1038/sj.mp.4001696)
- Khan, I. A. et al. 2006. In silico discrimination of single nucleotide polymorphisms and pathological mutations in human gene promoter regions by means of local DNA sequence context and regularity.. In silico Biology 6 (1-2), pp.23-34.
- Kim, Y. et al., 2013. Non-random mating, parent-of-origin, and maternal-fetal incompatibility effects in schizophrenia. Schizophrenia Research 143 (1), pp.11-17. (10.1016/j.schres.2012.11.002)
- Kirov, G. et al. 2003. Variation in the protocadherin - A gene cluster?. Genomics 82 (4), pp.433-440. (10.1016/S0888-7543(03)00167-8)
- Kirov, G. et al. 2009. Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Human Molecular Genetics 18 (8), pp.1497-1503. (10.1093/hmg/ddp043)
- Kirov, G. et al. 2008. Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Human Molecular Genetics 17 (3), pp.458-465. (10.1093/hmg/ddm323)
- Kirov, G. et al. 2004. Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biological psychiatry 55 (10), pp.971-975. (10.1016/j.biopsych.2004.01.025)
- Kirov, G. et al. 2001. Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder. Molecular Psychiatry 6 (6), pp.671-677. (10.1038/sj.mp.4000899)
- Kirov, G. et al. 2006. Pooled DNA genotyping on Affymetrix SNP genotyping arrays. BMC Genomics 7 (1), pp.27-37. (10.1186/1471-2164-7-27)
- Kirov, G. , O'Donovan, M. C. and Owen, M. J. 2005. Finding schizophrenia genes. The Journal of Clinical Investigation 115 (6), pp.1440-1448. (10.1172/JCI24759)
- Kirov, G. et al. 2012. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Molecular Psychiatry 17 (2), pp.142-153. (10.1038/mp.2011.154)
- Kirov, G. et al. 2013. The penetrance of copy number variations for schizophrenia and developmental delay. Biological Psychiatry 75 (5), pp.378-385. (10.1016/j.biopsych.2013.07.022)
- Kirov, G. et al. 2009. Neurexin 1 (NRXN1) deletions in Schizophrenia. Schizophrenia Bulletin 35 (5), pp.851-854. (10.1093/schbul/sbp079)
- Kirov, G. et al. 2000. Automated genotyping of single-nucleotide polymorphisms by extension of fluorescently labelled primers: analysis of individual and pooled DNA samples. Balkan Journal of Medical Genetics 3 , pp.23-28.
- Kirov, G. et al. 2008. A genome-wide association study in 574 schizophrenia trios using DNA pooling. Molecular Psychiatry 14 (8), pp.796-803. (10.1038/mp.2008.33)
- Kronenberg, F. et al., 2013. Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease [Article]. PLoS ONE 8 (4), pp.e59905. (10.1371/journal.pone.0059905)
- Lambert, J. C. et al., 2012. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. Molecular Psychiatry 18 , pp.461-470. (10.1038/mp.2012.14)
- Lambert, J. C. et al., 2013. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease [Correction]. Molecular Psychiatry 18 (4), pp.521. (10.1038/mp.2012.75)
- Lambert, J. et al., 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease [Letter]. Nature Genetics 45 (12), pp.1452-1458. (10.1038/ng.2802)
- Lancaster, T. et al. 2016. Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals. Human Brain Mapping 37 (2), pp.491-500. (10.1002/hbm.23044)
- Landerl, K. et al., 2013. Predictors of developmental dyslexia in European orthographies with varying complexity. Journal of Child Psychology and Psychiatry 54 (6), pp.686-694. (10.1111/jcpp.12029)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18 (1), pp.26-32. (10.1007/s00787-008-0698-4)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196 (3), pp.235-240. (10.1192/bjp.bp.109.066274)
- Langley, K. et al. 2010. Genotype link with extreme antisocial behavior: The contribution of cognitive pathways. Archives of General Psychiatry 67 (12), pp.1317-1323. (10.1001/archgenpsychiatry.2010.163)
- Langley, K. et al. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161 (1), pp.133-138. (10.1176/appi.ajp.161.1.133)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199 (5), pp.398-403.
- Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13 (2), pp.107-110. (10.1097/01.ypg.0000056177.32550.a5)
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B (1), pp.7-10. (10.1002/ajmg.b.30206)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (1), pp.49-53. (10.1002/ajmg.b.30571)
- Lawson, D. C. et al., 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B (1), pp.84-89. (10.1002/ajmg.b.10002)
- Lee, S. et al., 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45 (9), pp.984-994. (10.1038/ng.2711)
- Lee, S. H. et al., 2015. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology 44 (5), pp.1706-1721. (10.1093/ije/dyv136)
- Levinson, D. F. et al., 2002. No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science 296 (5568), pp.739-741. (10.1126/science.1069914)
- Levinson, D. F. et al., 2012. Genome-wide association study of multiplex schizophrenia pedigrees. American Journal of Psychiatry 169 (9), pp.963-973. (10.1176/appi.ajp.2012.11091423)
- Lewis, C. M. et al., 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder, Part II: schizophrenia. American Journal of Human Genetics 73 (1), pp.34-48. (10.1086/376549)
- Lewis, G. et al., 2011. Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial. British Journal of Psychiatry 198 (6), pp.464-471. (10.1192/bjp.bp.110.082727)
- Li, T. et al., 1998. Analysis of CAG/CTG repeat size in Chinese subjects with schizophrenia and bipolar affective disorder using the repeat expansion detection method. Biological psychiatry 44 (11), pp.1160-1165. (10.1016/S0006-3223(97)00492-7)
- Li, Y. et al., 2008. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human Molecular Genetics 17 (5), pp.759-767. (10.1093/hmg/ddm348)
- Li, Y. et al., 2005. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Human Mutation 25 (3), pp.270-277. (10.1002/humu.20138)
- Li, Y. et al., 2006. DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Human Molecular Genetics 15 (17), pp.2560-2568. (10.1093/hmg/ddl178)
- Li, Y. et al., 2008. SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiology of Disease 29 (2), pp.293-296. (10.1016/j.nbd.2007.09.001)
- Lips, E. S. et al., 2011. Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Molecular Psychiatry , pp.1-11. (10.1038/mp.2011.117)
- Liu, G. et al., 2014. Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies. Neurobiology of Aging 35 (4), pp.786-92. (10.1016/j.neurobiolaging.2013.10.084)
- Liu, Y. et al., 2010. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder [Letter]. Molecular Psychiatry 16 (1), pp.2-4. (10.1038/mp.2009.107)
- Liu, Y. et al., 2009. Whole genome association study in a homogenous population in Shandong Peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia. Journal of Biomedicine and Biotechnology 536918. (10.1155/2009/536918)
- Loh, P. et al., 2015. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nature Genetics 47 , pp.1385-1392. (10.1038/ng.3431)
- Loos, R. J. F. et al., 2008. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 40 (6), pp.768-775. (10.1038/ng.140)
- Maier, R. et al., 2015. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. American Journal of Human Genetics 96 (2), pp.283-294. (10.1016/j.ajhg.2014.12.006)
- Majounie, E. et al. 2013. Variation in tau isoform expression in different brain regions and disease states. Neurobiology of Aging 34 (7), pp.1922.e7-1922.e12. (10.1016/j.neurobiolaging.2013.01.017)
- Martin, J. et al. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5 e506. (10.1038/tp.2015.5)
- Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53 (7), pp.761-770.e26. (10.1016/j.jaac.2014.03.004)
- Martin, J. et al. 2014. Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders 44 (1), pp.204-215. (10.1007/s10803-013-1865-0)
- Martin, J. et al. 2014. Genetic risk for Attention Deficit/Hyperactivity Disorder contributes to neurodevelopmental traits in the general population. Biological Psychiatry 76 (8), pp.664-671. (10.1016/j.biopsych.2014.02.013)
- Martin, J. et al. 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 56 (6), pp.648-656. (10.1111/jcpp.12336)
- McCarthy, S. E. et al., 2009. Microduplications of 16p11.2 are associated with schizophrenia. Nature Genetics 41 (11), pp.1223-1227. (10.1038/ng.474)
- McGuffin, P. and O'Donovan, M. C. 1993. Taking a balanced view on triazolam. British Medical Journal (BMJ) 306 (6893), pp.1690-1691. (10.1136/bmj.306.6893.1690-c)
- Mechelli, A. et al., 2010. Dysbindin modulates brain function during visual processing in children. NeuroImage 49 (1), pp.817-822. (10.1016/j.neuroimage.2009.07.030)
- Mills, S. et al., 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4 , pp.15-15. (10.1186/1471-244X-4-15)
- Morgan, A. R. et al. 2009. Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (1), pp.61-64. (10.1002/ajmg.b.30768)
- Morgan, A. et al., 2007. Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (6), pp.727-731. (10.1002/ajmg.b.30670)
- Morgan, A. et al., 2007. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B (6), pp.762-770. (10.1002/ajmg.b.30509)
- Morris, D. W. et al., 2014. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Human Molecular Genetics 23 (12), pp.3316-3326. (10.1093/hmg/ddu025)
- Morris, D. W. et al., 2000. Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q. Human Molecular Genetics 9 (5), pp.843-848. (10.1093/hmg/9.5.843)
- Morris, D. et al., 2004. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. American Journal Of Medical Genetics Part A 129B (1), pp.97-103. (10.1002/ajmg.b.30033)
- Mowry, B. J. et al., 2004. Multicenter linkage study of schizophrenia loci on chromosome 22q. Molecular Psychiatry 9 (8), pp.784-795. (10.1038/sj.mp.4001481)
- Mulle, J. G. et al., 2014. Reciprocal duplication of the Williams-Beuren Syndrome deletion on chromosome 7q11.23 is associated with schizophrenia. Biological Psychiatry 75 (5), pp.371-7. (10.1016/j.biopsych.2013.05.040)
- Murphy, K. et al., 2004. What can velo-cardio-facial syndrome tell us about the genetics of schizophrenia?. European Psychiatry 19 (Supp1), pp.96S-96S.
- Myers, A. J. et al., 2004. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics 124B (1), pp.29-37. (10.1002/ajmg.b.20036)
- Neale, B. M. et al., 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49 (9), pp.884-897. (10.1016/j.jaac.2010.06.008)
- Nejentsev, S. et al., 2007. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450 (7171), pp.887-892. (10.1038/nature06406)
- Ng, M. Y. M. et al., 2009. Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Molecular Psychiatry 14 (8), pp.774-785. (10.1038/mp.2008.135)
- Norton, N. et al., 2004. Interaction between neuregulin 1 and its receptor ERBB4 increases susceptibility to schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.18-18.
- Norton, N. et al., 2003. Mutation screening of the Homer gene family and association analysis in schizophrenia. American Journal of Medical Genetics 120B (1), pp.18-21. (10.1002/ajmg.b.20032)
- Norton, N. et al. 2006. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B (1), pp.96-101. (10.1002/ajmg.b.30236)
- Norton, N. et al., 2002. Schizophrenia and functional polymorphisms in the MAOA and COMT genes: No evidence for association or epistasis. American Journal Of Medical Genetics Part A 114 (5), pp.491-496. (10.1002/ajmg.10517)
- Norton, N. et al., 2005. No evidence for association between polymorphisms in GRM3 and schizophrenia. BMC Psychiatry 5 23. (10.1186/1471-244X-5-23)
- Norton, N. et al., 2007. Association analysis of AKT1 and schizophrenia in a UK case control sample. Schizophrenia Research 93 (1-3), pp.58-65. (10.1016/j.schres.2007.02.006)
- Norton, N. et al., 2004. DNA pooling as a tool for large-scale association studies in complex traits. Annals of Medicine 36 (2), pp.146-152. (10.1080/07853890310021724)
- Norton, N. et al., 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110 (5), pp.471-478. (10.1007/s00439-002-0706-6)
- Nowotny, P. et al., 2005. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 136B (1), pp.62-68. (10.1002/ajmg.b.30186)
- O'Donovan, M. et al. 2006. Genetic dissection of behavioural abnormalities in mouse models of DiGeorge/velocardiofacial syndrome. Journal of intellectual disability research 50 (11), pp.781 -781.
- O'Donovan, M. C. 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 (6), pp.971-983. (10.1016/0092-8674(93)90585-E)
- O'Donovan, M. C. 2005. An evaluation of chromatin condensation and DNA integrity in the spermatozoa of men with cancer before and after therapy. Andrologia -Berlin- 37 (2-3), pp.83-90. (10.1111/j.1439-0272.2005.00658.x)
- O'Donovan, M. C. 1996. Genetics of Mental disorders .1. Theoretical aspects - Mendlewicz,J, Papadimitriou,GN. British Journal of Psychiatry 168 (2), pp.256-256.
- O'Donovan, M. C. 2015. Novel genetic advances in schizophrenia: an interview with Michael O'Donovan. BMC Medicine 13 181. (10.1186/s12916-015-0417-1)
- O'Donovan, M. C. 2015. What have we learned from the Psychiatric Genomics Consortium. World Psychiatry 14 (3), pp.291-293. (10.1002/wps.20270)
- O'Donovan, M. C. and Buckland, P. R. 1991. Simultaneous quantification of several mRNA species by solution hybridisation with oligonucleotides. Nucleic Acids Research 19 (12), pp.3466. (10.1093/nar/19.12.3466)
- O'Donovan, M. C. , Buckland, P. R. and McGuffin, P. 1992. The expression of neuroreceptor genes and benzodiazepine tolerance.. Clinical Neuropharmacology 15 (Supp1), pp.218A-219A. (10.1097/00002826-199201001-00114)
- O'Donovan, M. C. , Buckland, P. R. and McGuffin, P. 1992. Levels of GABAa receptor subunit mRNA in rat brain following flurazepam treatment. Journal of Psychopharmacology 6 (3), pp.364-369. (10.1177/026988119200600304)
- O'Donovan, M. C. et al. 1992. Bi-directional changes in the levels of messenger RNAs encoding γ-aminobutyric acidA receptor α subunits after flurazepam treatment. European Journal of Pharmacology: Molecular Pharmacology 226 (4), pp.335-341. (10.1016/0922-4106(92)90051-V)
- O'Donovan, M. C. et al. 1996. Involvement of expanded trinucleotide repeats in common diseases. The Lancet 348 (9043), pp.1739-1740. (10.1016/s0140-6736(05)65870-9)
- O'Donovan, M. C. et al. 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics 40 (9), pp.1053-1055. (10.1038/ng.201)
- O'Donovan, M. C. , Craddock, N. J. and Owen, M. J. 2009. Genetics of psychosis; insights from views across the genome. Human Genetics 126 (1), pp.3-12. (10.1007/s00439-009-0703-0)
- O'Donovan, M. C. , Craddock, N. J. and Owen, M. J. 2008. Schizophrenia: complex genetics, not fairy tales. Psychological Medicine 38 (12), pp.1697-1699. (10.1017/S0033291708003802)
- O'Donovan, M. C. , Craddock, N. J. and Owen, M. J. 2009. Strong evidence for multiple psychosis susceptibility genes - a rejoinder to Crow [Letter]. Psychological Medicine 39 (1), pp.170-171. (10.1017/S0033291708004583)
- O'Donovan, M. C. and Guy, C. 1997. Bias in the genomic distribution of CAG and CTG trinucleotide repeats. American Journal of Medical Genetics 74 (1), pp.62-64. (10.1002/(SICI)1096-8628(19970221)74:1<62::AID-AJMG14>3.0.CO;2-P)
- O'Donovan, M. C. et al. 1996. Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychological Medicine -London- 26 (6), pp.1145-1153. (10.1017/s0033291700035868)
- O'Donovan, M. C. et al. 1995. Expanded CAG repeats in schizophrenia and bipolar disorder [letter]. Nature Genetics 10 (4), pp.380-381. (10.1038/ng0895-380)
- O'Donovan, M. C. et al. 2007. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia [Conference Abstract]. Schizophrenia bulletin 33 (2), pp.311-312. (10.1093/schbul/sbm004)
- O'Donovan, M. C. , Jones, I. R. and Craddock, N. J. 2003. Anticipation and repeat expansion in bipolar disorder. American Journal of Medical Genetics 123C (1), pp.10-17. (10.1002/ajmg.c.20009)
- O'Donovan, M. C. , Kirov, G. and Owen, M. J. 2008. Phenotypic variations on the theme of CNVs. Nature Genetics 40 (12), pp.1392-1393. (10.1038/ng1208-1392)
- O'Donovan, M. C. and McGuffin, P. 1993. Correction: Short acting benzodiazepines. British Medical Journal (BMJ) 306 (6886), pp.1146-1146. (10.1136/bmj.306.6886.1146)
- O'Donovan, M. C. and McGuffin, P. 1991. Growing points in psychiatric genetics. British Journal of Hospital Medicine 46 (6), pp.359-360.
- O'Donovan, M. C. and McGuffin, P. 1993. Short acting benzodiazepines.. British Medical Journal (BMJ) 306 (6883), pp.945-946. (10.1136/bmj.306.6883.945)
- O'Donovan, M. C. et al. 2009. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry 14 (1), pp.30-36. (10.1038/mp.2008.108)
- O'Donovan, M. C. et al. 1998. Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection. Genomics 52 (1), pp.44-49. (10.1006/geno.1998.5411)
- O'Donovan, M. C. and Owen, M. J. 1992. Advances and Retreats in the Molecular Genetics of Major Mental Illness. Annals of Medicine 24 (3), pp.171-177. (10.3109/07853899209147816)
- O'Donovan, M. C. and Owen, M. J. 1999. Candidate-gene association studies of schizophrenia. American Journal of Human Genetics 65 (3), pp.587-592. (10.1086/302560)
- O'Donovan, M. C. and Owen, M. J. 1996. Dynamic mutations and psychiatric genetics. Psychological Medicine 26 (1), pp.1-6. (10.1017/S0033291700033663)
- O'Donovan, M. C. and Owen, M. J. 2009. Genetics and the brain: many pathways to enlightenment [Editorial]. Human Genetics 126 (1), pp.1-2. (10.1007/s00439-009-0705-y)
- O'Donovan, M. C. et al. 2012. Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biological psychiatry 72 (8), pp.620-628. (10.1016/j.biopsych.2012.05.035)
- O'Donovan, M. C. , Williams, N. M. and Owen, M. J. 2003. Recent advances in the genetics of schizophrenia. Human Molecular Genetics 12 (suppl), pp.R125-R133. (10.1093/hmg/ddg302)
- O'Dushlaine, C. et al., 2011. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Molecular Psychiatry 16 (3), pp.286-292. (10.1038/mp.2010.7)
- O'Dushlaine, C. et al., 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 18 (2), pp.199-209. (10.1038/nn.3922)
- Oertel-Knöchel, V. et al., 2015. Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts. NeuroImage: Clinical 7 , pp.764-770. (10.1016/j.nicl.2015.03.005)
- Oretti, R. G. et al., 1998. Tryptophan pyrrolase gene expression in an alcohol preferring and non-preferring mouse strain. Addiction Biology 3 (1), pp.71-77. (10.1080/13556219872362)
- Orozco, G. et al., 2009. Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Human Molecular Genetics 18 (14), pp.2693-2699. (10.1093/hmg/ddp193)
- Owen, M. J. , Cardno, A. G. and O'Donovan, M. C. 2000. Psychiatric genetics: back to the future. Molecular Psychiatry 5 (1), pp.22-31. (10.1038/sj.mp.4000702)
- Owen, M. J. , Craddock, N. J. and O'Donovan, M. C. 2005. Schizophrenia: genes at last?. Trends in Genetics 21 (9), pp.518-525. (10.1016/j.tig.2005.06.011)
- Owen, M. J. , Craddock, N. J. and O'Donovan, M. C. 2010. Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia. Archives of General Psychiatry 67 (7), pp.667-673. (10.1001/archgenpsychiatry.2010.69)
- Owen, M. J. , O'Donovan, M. C. and Harrison, P. J. 2005. Schizophrenia: a genetic disorder of the synapse?. British Medical Journal (BMJ) 330 (7484), pp.158-159. (10.1136/bmj.330.7484.158)
- Owen, M. J. et al. 2011. Neurodevelopmental hypothesis of schizophrenia. British Journal of Psychiatry 198 (3), pp.173-175. (10.1192/bjp.bp.110.084384)
- Owen, M. J. , Williams, H. J. and O'Donovan, M. C. 2009. Schizophrenia genetics: advancing on two fronts. Current Opinion in Genetics & Development 19 (3), pp.266-270. (10.1016/j.gde.2009.02.008)
- Owen, M. J. , Williams, N. M. and O'Donovan, M. C. 2004. Dysbindin-1 and schizophrenia: from genetics to neuropathology. The Journal of Clinical Investigation 113 (9), pp.1255-1257. (10.1172/JCI200421470)
- Owen, M. J. , Williams, N. M. and O'Donovan, M. C. 2004. The molecular genetics of schizophrenia: new findings promise new insights. Molecular Psychiatry 9 (1), pp.14-27. (10.1038/sj.mp.4001444)
- Pagnamenta, A. T. et al., 2010. Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biological psychiatry 68 (4), pp.320-328. (10.1016/j.biopsych.2010.02.002)
- Paylor, R. et al., 2006. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: Implications for 22q11 deletion syndrome. Proceedings of the National Academy of Sciences of the United States of America 103 (20), pp.7729-7734. (10.1073/pnas.0600206103)
- Payton, A. et al., 2001. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. Neuroscience Letters 105 (5), pp.464-470. (10.1002/ajmg.1407)
- Payton, A. et al., 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13 (3), pp.183-185.
- Peirce, T. R. et al., 2004. Convergent functional genomics, association and linkage analysis suggests 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase (CNP) as a potential susceptibility gene for schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B (1), pp.81-81. (10.1002/ajmg.b.30101)
- Peirce, T. R. et al. 2006. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of general psychiatry 63 (1), pp.18-24. (10.1001/archpsyc.63.1.18)
- Peirce, T. et al., 2006. Convergent evidence for 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of General Psychiatry 63 (1), pp.18-24.
- Plomin, R. et al., 2004. A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability. Molecular Psychiatry 9 (6), pp.582-586. (10.1038/sj.mp.4001441)
- Pocklington, A. , O'Donovan, M. C. and Owen, M. J. 2014. The synapse in schizophrenia. European Journal of Neuroscience 39 (7), pp.1059-1067. (10.1111/ejn.12489)
- Pocklington, A. et al. 2015. Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia. Neuron 86 (5), pp.1203-1214. (10.1016/j.neuron.2015.04.022)
- Prata, D. P. et al., 2013. Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity. Human Brain Mapping 34 (9), pp.2025-2031. (10.1002/hbm.22045)
- Purcell, S. M. et al., 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460 (7256), pp.748-752. (10.1038/nature08185)
- Raybould, R. et al. 2005. Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biological psychiatry 57 (7), pp.696-701. (10.1016/j.biopsych.2005.01.018)
- Redfern, A. et al., 2005. Global gene expression profiling in the hippocampus and frontal cortex of Escitalopram-treated Learned Helplessness rats. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 138B (1), pp.107-107.
- Rees, E. et al. 2011. De novo rates and selection of schizophrenia-associated copy number variants. Biological Psychiatry 70 (12), pp.1109-1114. (10.1016/j.biopsych.2011.07.011)
- Rees, E. et al. 2012. De Novo mutation in schizophrenia. Schizophrenia Bulletin 38 (3), pp.377-381. (10.1093/schbul/sbs047)
- Rees, E. et al. 2013. Evidence that duplications of 22q11.2 protect against schizophrenia. Molecular Psychiatry n/a (10.1038/mp.2013.156)
- Rees, E. et al. 2015. Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia. Translational Psychiatry 5 (7) e607. (10.1038/tp.2015.99)
- Rees, E. , O'Donovan, M. C. and Owen, M. J. 2015. Genetics of schizophrenia. Current Opinion in Behavioral Sciences 2 , pp.8-14. (10.1016/j.cobeha.2014.07.001)
- Rees, E. et al. 2014. CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. Human Molecular Genetics 23 (6), pp.1669-1676. (10.1093/hmg/ddt540)
- Rees, E. et al. 2014. Analysis of copy number variations at 15 schizophrenia-associated loci. British Journal of Psychiatry 204 (2), pp.108-114. (10.1192/bjp.bp.113.131052)
- Reilly, M. P. et al., 2011. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. The Lancet 377 (9763), pp.383-392. (10.1016/S0140-6736(10)61996-4)
- Richards, A. et al. 2012. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Molecular Psychiatry 17 (2), pp.193-201. (10.1038/mp.2011.11)
- Richards, A. et al. 2016. Exome arrays capture polygenic rare variant contributions to schizophrenia. Human Molecular Genetics 25 (5), pp.1001-1007. (10.1093/hmg/ddv620)
- Richards, A. L. et al. 2008. A comparison of four clustering methods for brain expression microarray data. BMC Bioinformatics 9 490. (10.1186/1471-2105-9-490)
- Rietschel, M. et al., 2011. Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe. Molecular Psychiatry , pp.1-12. (10.1038/mp.2011.80)
- Ripke, S. et al., 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics 45 (10), pp.1150-1159. (10.1038/ng.2742)
- Ripke, S. et al., 2011. Genome-wide association study identifies five new schizophrenia loci [Letter]. Nature Genetics 43 (10), pp.969-976. (10.1038/ng.940)
- Ripke, S. et al., 2013. A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry 18 (4), pp.497-511. (10.1038/mp.2012.21)
- Robinson, E. B. et al., 2014. Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'. Molecular Psychiatry 19 (8), pp.860-1. (10.1038/mp.2013.125)
- Ruderfer, D. et al., 2013. Mosaic copy number variation in schizophrenia. European Journal of Human Genetics 21 (9), pp.1007-1011. (10.1038/ejhg.2012.287)
- Ruderfer, D. M. et al., 2014. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Molecular Psychiatry 19 (9), pp.1017-1024. (10.1038/mp.2013.138)
- Ruderfer, D. M. et al., 2011. A family-based study of common polygenic variation and risk of schizophrenia [Letter]. Molecular Psychiatry 16 (9), pp.887-888. (10.1038/mp.2011.34)
- Sakuntabhai, A. et al., 1999. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nature Genetics 21 (3), pp.271-277.
- Schmidts, M. et al., 2015. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications 6 7074. (10.1038/ncomms8074)
- Sham, P. et al., 2002. DNA Pooling: a tool for large-scale association studies. Nature Reviews Genetics 3 (11), pp.862-871. (10.1038/nrg930)
- Shi, H. et al., 2012. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging 33 (8) 1849.e5. (10.1016/j.neurobiolaging.2012.02.014)
- Shifman, S. et al., 2008. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLOS Genetics 4 (2) e28. (10.1371/journal.pgen.0040028)
- Sims, R. et al. 2011. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (7), pp.764-771. (10.1002/ajmg.b.31216)
- Sims, R. et al. 2009. Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease. Neuroscience Letters 461 (1), pp.54-59. (10.1016/j.neulet.2009.05.051)
- Sklar, P. et al., 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 [Letter]. Nature Genetics 43 (10), pp.977-983. (10.1038/ng.943)
- Smemo, S. et al., 2006. Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Annals of Neurology 59 (1), pp.21-26. (10.1002/ana.20673)
- Smith, R. L. et al. 2011. Analysis of neurogranin (NRGN) in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B (5), pp.532-535. (10.1002/ajmg.b.31191)
- Smith, S. K. et al. 2003. Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission. Psychiatric Genetics 13 (4), pp.193-199. (10.1097/00041444-200312000-00001)
- Smoller, J. W. et al., 2013. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet 381 (9875), pp.1371-1379. (10.1016/S0140-6736(12)62129-1)
- Speight, G. et al., 1997. Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia. American Journal of Medical Genetics 74 (2), pp.204-206. (10.1002/(SICI)1096-8628(19970418)74:2<204::AID-AJMG19>3.0.CO;2-M)
- Speight, G. et al., 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5 (3), pp.327-331. (10.1038/sj.mp.4000717)
- Spiers, H. et al., 2015. Methylomic trajectories across human fetal brain development. Genome Research 25 (3), pp.338-352. (10.1101/gr.180273.114)
- Spurlock, G. et al., 1994. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter. Neuropharmacology 33 (3-4), pp.433-440. (10.1016/0028-3908(94)90073-6)
- Steinberg, S. et al., 2011. Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Human Molecular Genetics 20 (20), pp.4076-4081. (10.1093/hmg/ddr325)
- Steinberg, S. et al., 2014. Common variant at 16p11.2 conferring risk of psychosis. Molecular Psychiatry 19 (1), pp.108-114. (10.1038/mp.2012.157)
- Stergiakouli, E. et al., 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54 (4), pp.322-327. (10.1016/j.jaac.2015.01.010)
- Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169 (2), pp.186-194. (10.1176/appi.ajp.2011.11040551)
- Stergiakouli, E. et al., 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10 (3), pp.334-344. (10.1111/j.1601-183x.2010.00672.x)
- Stone, J. L. et al., 2008. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455 (7210), pp.237-241. (10.1038/nature07239)
- Sullivan, P. et al., 2012. Don't give up on GWAS [Letter]. Molecular Psychiatry 17 (1), pp.2-3. (10.1038/mp.2011.94)
- Sullivan, P. F. , Daly, M. J. and O'Donovan, M. C. 2012. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nature Reviews Genetics 13 (8), pp.537-551. (10.1038/nrg3240)
- Szatkiewicz, J. P. et al., 2014. Copy number variation in schizophrenia in Sweden. Molecular Psychiatry 19 (7), pp.762-773. (10.1038/mp.2014.40)
- Talkowski, M. E. et al., 2007. A network of dopaminergic gene variations implicated as risk factors for schizophrenia. Human Molecular Genetics 17 (5), pp.747-758. (10.1093/hmg/ddm347)
- Talkowski, M. E. et al., 2010. Fine-mapping reveals novel alternative splicing of the dopamine transporter. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B (8), pp.1434-1447. (10.1002/ajmg.b.31125)
- Talkowski, M. E. et al., 2009. Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B (4), pp.560-569. (10.1002/ajmg.b.30862)
- Talkowski, M. E. et al., 2006. Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. Biological psychiatry 60 (2), pp.152-162. (10.1016/j.biopsych.2006.02.015)
- Tansey, K. E. et al. 2016. Common alleles contribute to schizophrenia in CNV carriers. Molecular Psychiatry 21 , pp.1085-1089. (10.1038/mp.2015.143)
- Tansey, K. et al. 2014. Genetic susceptibility for bipolar disorder and response to antidepressants in major depressive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 165 (1), pp.77-83. (10.1002/ajmg.b.32210)
- Tansey, K. et al. 2014. Copy number variants and therapeutic response to antidepressant medication in major depressive disorder. The Pharmacogenomics Journal 14 (4), pp.395-399. (10.1038/tpj.2013.51)
- Tansey, K. E. et al. 2012. Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. Plos Medicine 9 (10) e1001326. (10.1371/journal.pmed.1001326)
- Tansey, K. E. , Owen, M. J. and O'Donovan, M. C. 2015. Schizophrenia genetics: Building the foundations of the future. Schizophrenia Bulletin 41 (1), pp.15-19. (10.1093/schbul/sbu162)
- Taylor, P. N. et al. 2015. Whole-genome sequence-based analysis of thyroid function. Nature Communications 6 5681. (10.1038/ncomms6681)
- Terwisscha van Scheltinga, A. F. et al., 2013. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry 73 (6), pp.525-531. (10.1016/j.biopsych.2012.08.017)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21 , pp.1202-1207. (10.1038/mp.2015.163)
- Thapar, A. et al. 1994. The genetics of mental retardation. The British Journal of Psychiatry 164 (6), pp.747. (10.1192/bjp.164.6.747)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64 (3), pp.378-379. (10.1001/archpsyc.64.3.378-b)
- Thapar, A. et al. 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19 (04), pp.989-1004. (10.1017/S0954579407000491)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62 (11), pp.1275-1278. (10.1001/archpsyc.62.11.1275)
- Thapar, A. et al. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33 (6), pp.721-721.
- Thapar, A. et al. 2006. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 11 (8), pp.714-20. (10.1038/sj.mp.4001831)
- Thapar, A. et al. 2007. Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine 37 (12), pp.1681-1692. (10.1017/S0033291707000773)
- Thapar, A. , O'Donovan, M. C. and Owen, M. J. 2005. The genetics of attention deficit hyperactivity disorder. Human Molecular Genetics 14 (2), pp.275-282. (10.1093/hmg/ddi263)
- Thomas, L. et al., 2008. GENetic and clinical predictors of treatment response in depression: the GenPod randomised trial protocol. Trials 9 (1), pp.29-29. (10.1186/1745-6215-9-29)
- Thomson, W. et al., 2007. Rheumatoid arthritis association at 6q23. Nature Genetics 39 (12), pp.1431-1433. (10.1038/ng.2007.32)
- Timpson, N. J. et al., 2014. A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nature Communications 5 4871. (10.1038/ncomms5871)
- Tognin, S. et al., 2011. Effects of DTNBP1 genotype on brain development in children. Journal of Child Psychology and Psychiatry 52 (12), pp.1287-1294. (10.1111/j.1469-7610.2011.02427.x)
- Turic, D. et al., 2004. Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD. American Journal of Medical Genetics 127B (1), pp.68-72. (10.1002/ajmg.b.20173)
- Turic, D. et al., 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57 (11), pp.1461-1466. (10.1016/j.biopsych.2005.03.025)
- Turic, D. et al., 2003. Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22. Molecular Psychiatry 8 (2), pp.176-185. (10.1038/sj.mp.4001216)
- Turic, D. et al., 2005. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B (1), pp.64-67. (10.1002/ajmg.b.30123)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9 (2), pp.169-173. (10.1038/sj.mp.4001387)
- van Goozen, S. H. M. et al. 2016. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. Journal of Child Psychology and Psychiatry 57 (4), pp.472-480. (10.1111/jcpp.12464)
- van Scheltinga, A. F. T. et al., 2013. Schizophrenia genetic variants are not associated with intelligence. Psychological Medicine 43 (12), pp.2563-2570. (10.1017/S0033291713000196)
- Vilhjálmsson, B. et al., 2015. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. American Journal of Human Genetics 97 (4), pp.576-592. (10.1016/j.ajhg.2015.09.001)
- Vincent, J. B. et al., 2000. Long repeat tracts at SCA8 in major psychosis. American Journal of Medical Genetics 96 (6), pp.873-876. (10.1002/1096-8628(20001204)96:6<873::AID-AJMG37>3.0.CO;2-9)
- Visscher, P. M. et al., 2013. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genetics 9 (4), pp.e1003455. (10.1371/journal.pgen.1003455)
- Walter, K. et al., 2015. The UK10K project identifies rare variants in health and disease. Nature 526 , pp.82-90. (10.1038/nature14962)
- Walters, J. T. R. et al. 2010. Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Archives of General Psychiatry 67 (7), pp.692-700. (10.1001/archgenpsychiatry.2010.81)
- Walters, J. T. R. et al. 2013. The role of the major histocompatibility complex region in cognition and brain structure: a schizophrenia GWAS follow-up. American Journal of Psychiatry 170 (8), pp.877-885. (10.1176/appi.ajp.2013.12020226)
- West, A. et al., 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7 (9), pp.962-966. (10.1038/sj.mp.4001129)
- Wiles, N. J. et al., 2011. Severity of depression and response to antidepressants: GENPOD randomised controlled trial. British Journal of Psychiatry 200 (2), pp.130-136. (10.1192/bjp.bp.110.091223)
- Williams, H. J. et al., 2005. No association between schizophrenia and polymorphisms in COMT in two large samples. American Journal of Psychiatry 162 (9), pp.1736-1738. (10.1176/appi.ajp.162.9.1736)
- Williams, H. J. et al., 2003. Association between PRODH and schizophrenia is not confirmed. Molecular Psychiatry 8 (7), pp.644-645. (10.1038/sj.mp.4001276)
- Williams, H. et al., 2003. Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia. American Journal of Medical Genetics 120B (1), pp.42-46. (10.1002/ajmg.b.20049)
- Williams, H. et al., 2007. Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia. Schizophrenia Research 97 (1-3), pp.271-276. (10.1016/j.schres.2007.09.004)
- Williams, H. , Owen, M. J. and O'Donovan, M. C. 2007. Is COMT a susceptibility gene for schizophrenia?. Schizophrenia Bulletin 33 (3), pp.635-641. (10.1093/schbul/sbm019)
- Williams, H. , Owen, M. J. and O'Donovan, M. C. 2009. Schizophrenia genetics: new insights from new approaches. British Medical Bulletin 91 (1), pp.61-74. (10.1093/bmb/ldp017)
- Williams, H. J. et al. 2011. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Human Molecular Genetics 20 (2), pp.387-391. (10.1093/hmg/ddq471)
- Williams, H. J. et al. 2011. Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156 (7), pp.781-784. (10.1002/ajmg.b.31219)
- Williams, H. J. et al. 2012. Absence of de novo point mutations in exons of GRIN2B in a large schizophrenia trio sample [Letter]. Schizophrenia Research 141 (2-3), pp.274-276. (10.1016/j.schres.2012.08.024)
- Williams, H. J. et al. 2013. Schizophrenia two-hit hypothesis in velo-cardio facial syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162 (2), pp.177-182. (10.1002/ajmg.b.32129)
- Williams, H. J. et al. 2011. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Molecular Psychiatry 16 (4), pp.429-441. (10.1038/mp.2010.36)
- Williams, H. J. , Owen, M. J. and O'Donovan, M. C. 2009. New findings from genetic association studies of schizophrenia. Journal of Human Genetics 54 (1), pp.9-14. (10.1038/jhg.2008.7)
- Williams, J. and O'Donovan, M. C. 2006. The genetics of developmental dyslexia. European Journal of Human Genetics 14 (6), pp.681-89. (10.1038/sj.ejhg.5201575)
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7 (5), pp.508-514. (10.1038/sj.mp.4001030)
- Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169 (2), pp.195-204. (10.1176/appi.ajp.2011.11060822)
- Williams, N. M. et al. 2008. Strong evidence that GNB1L is associated with schizophrenia. Human Molecular Genetics 17 (4), pp.555-566. (10.1093/hmg/ddm330)
- Williams, N. M. et al. 2006. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Archives of General Psychiatry 63 (4), pp.366-373. (10.1001/archpsyc.63.4.366)
- Williams, N. M. et al. 2003. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. The American journal of human genetics 73 (6), pp.1355-1367. (10.1086/380206)
- Williams, N. M. , O'Donovan, M. C. and Owen, M. J. 2006. Chromosome 22 deletion syndrome and schizophrenia. International Review of Neurobiology 73 , pp.1-27. (10.1016/S0074-7742(06)73001-X)
- Williams, N. M. , O'Donovan, M. C. and Owen, M. J. 2002. Genome scans and microarrays: converging on genes for schizophrenia?. Genome Biology 3 (4), pp.Reviews1011-Reviews1011.5.
- Williams, N. M. , O'Donovan, M. C. and Owen, M. J. 2005. Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?. Schizophrenia Bulletin 31 (4), pp.800-805. (10.1093/schbul/sbi061)
- Williams, N. M. et al. 2011. Structural variations in attention-deficit hyperactivity disorder - Authors' reply [Letter]. The Lancet 377 (9763), pp.378. (10.1016/S0140-6736(11)60121-9)
- Williams, N. M. et al. 2003. Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Molecular Psychiatry 8 (5), pp.485-487. (10.1038/sj.mp.4001348)
- Williams, N. M. et al. 2004. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Archives of General Psychiatry 61 (4), pp.336-344. (10.1001/archpsyc.61.4.336)
- Williams, N. M. et al. 2004. Identification in two independent samples of a novel schizophrenia risk haplotype of the dystobrevin binding protein gene (DTNBP1). Archives of general psychiatry 61 (4), pp.336-344. (10.1001/archpsyc.61.4.336)
- Williams, N. M. et al. 2004. Support for RGS4 as a susceptibility gene for schizophrenia. Biological Psychiatry 55 (2), pp.192-195. (10.1016/j.biopsych.2003.11.002)
- Williams, N. M. et al. 2002. Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach. Molecular Psychiatry 7 (10), pp.1092-1100. (10.1038/sj.mp.4001188)
- Williams, N. M. et al. 2008. Analysis of copy number variation using quantitative interspecies competitive PCR. Nucleic Acids Research 36 (17), pp.e112-e112. (10.1093/nar/gkn495)
- Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376 (9750), pp.1401-1408. (10.1016/S0140-6736(10)61109-9)
- Yang, L. et al., 2013. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162 (5), pp.419-430. (10.1002/ajmg.b.32169)
- Yosifova, A. et al., 2011. Genome-wide association study on bipolar disorder in the Bulgarian population. Genes, Brain and Behavior 10 (7), pp.789-797. (10.1111/j.1601-183X.2011.00721.x)
- Yosifova, A. et al., 2009. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. Journal of Affective Disorders 117 (1-2), pp.87-97. (10.1016/j.jad.2008.12.021)
- Zaharieva, I. et al., 2008. Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping. BMC Psychiatry 8 (1), pp.11-11. (10.1186/1471-244X-8-11)
- Zammit, S. et al. 2013. A population-based study of genetic variation and psychotic experiences in adolescents. Schizophrenia Bulletin 40 (6), pp.1254-1262. (10.1093/schbul/sbt146)
- Zammit, S. et al. 2004. Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. American Journal of Medical Genetics 128B (1), pp.19-20. (10.1002/ajmg.b.30021)
- Zammit, S. et al. 2006. Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia. Journal of Psychiatric Research 40 (7), pp.622-626. (10.1016/j.jpsychires.2005.05.006)
- Zammit, S. et al. 2007. Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. British Journal of Psychiatry 191 (5), pp.402-407. (10.1192/bjp.bp.107.036129)
- Zou, F. et al., 2013. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's Disease pathology. PLoS ONE 8 (5) e64802. (10.1371/journal.pone.0064802)
- Zuliani, R. et al., 2011. Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry Research: Neuroimaging 191 (2), pp.133-137. (10.1016/j.pscychresns.2010.11.001)
Book sections
- O'Donovan, M. C. and Owen, M. J. 2003. Genetic findings in psychotic disorders. In: Soares, J. C. and Gershon, S. eds. Handbook of Medical Psychiatry. New York: Marcel Dekker. , pp.417-432.
- Owen, M. J. and O'Donovan, M. C. 2003. Schizophrenia and genetics. In: Plomin, R. et al., Behavioral Genetics in the Postgenomic Era. Washington, DC: APA Books. , pp.463-480. (10.1037/10480-023)
- Thapar, A. and O'Donovan, M. C. 2002. Neurogenetics. In: D'haenen, H. , den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley. , pp.167-180. (10.1002/0470854871.chxii)
- Zammit, S. , O'Donovan, M. C. and Owen, M. J. 2002. Neurogenetics of schizophrenia. In: D'haenen, H. , den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley. , pp.663-671. (10.1002/0470854871.chxvii9)
Books
- McGuffin, P. et al., 1994. Seminars in psychiatric genetics. Gaskell, Royal College of Psychiatrists.
Research
After obtaining my undergraduate qualifications in Physiology (BSc) and Medicine (MBChB) at the University of Glasgow, I specialized in psychiatry. I began my research career in 1989 as an MRC Training Fellow when I developed novel methods for quantitating mRNA, used these to show alterations in the relative expression of genes encoding subunits of GABAA receptors was a mechanism that contributes the biology of benzodiazepine tolerance, and obtained a PhD in Molecular Pharmacology.
1992-1993, I was an MRC Travelling Fellow at the laboratory of David Housman at MIT where I was a member of The Huntington's Disease Collaborative Research Group.
In 1993, I was appointed Senior Lecturer in the Department of Psychological Medicine, University of Wales College of Medicine, and was awarded a personal chair in Psychiatric Genetics in 1999. I have a broad interest in the molecular genetics and neurobiology of mental disorders and have held grants from many major funding bodies (MRC, Wellcome Trust, National Institute of Mental Health (USA), European Union) for molecular genetic studies of schizophrenia, bipolar disorder, dyslexia, ADHD, and Alzheimer's disease. I am currently the Chair of the Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Biography
- Professor of Psychiatric Genetics, MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
- Senior Lecturer in Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales; (Sept 1993-April 1999)
- Medical Research Council Travelling Fellow, Center for Cancer Research, Building E17/536, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge 02139-4307, USA; (September 1992 - August 1993)
- Medical Research Council Training Fellow, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales; (September 1989 - August 1992)
- Lecturer in Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales; (March 1988 - August 1989).
