![Michael O'Donovan](https://profiles-cardiff.imgix.net/attachments/2529?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Professor Michael O'Donovan
Professor, Division of Psychological Medicine and Clinical Neurosciences
Overview
Genetic variation makes important contributions to the aetiology of all major psychiatric disorders. Recent advances in molecular genetic technology offer unprecedented opportunities to identify specific risk genes for these disorders, and to use these findings as the basis for understanding the molecular basis of these hitherto enigmatic disorders. I am interested in identifying genes that contribute to susceptibility to a wide range of psychiatric disorders including schizophrenia, bipolar disorder, ADHD, and Alzheimer’s disease, and exploiting the findings to understanding the pathophysiological processes by which susceptibility is conferred.
Publication
2024
- Dempster, E. et al. 2024. Methylomic signature of current cannabis use in two first-episode psychosis cohorts. Molecular Psychiatry (10.1038/s41380-024-02689-0)
- Koch, E. et al. 2024. How real-world data can facilitate the development of precision medicine treatment in psychiatry. Biological Psychiatry 96(7), pp. 543-551. (10.1016/j.biopsych.2024.01.001)
- Tume, C. E., Chick, S. L., Holmans, P. A., Rees, E., O'Donovan, M. C., Cameron, D. and Bray, N. J. 2024. Genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. Biological Psychiatry 4(5), article number: 100345. (10.1016/j.bpsgos.2024.100345)
- Cameron, D. et al. 2024. Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia. Schizophrenia Bulletin Open 50(5), pp. 1171-1184. (10.1093/schbul/sbae083)
- González-Peñas, J. et al. 2024. Accelerated cortical thinning in schizophrenia is associated with rare and common predisposing variation to schizophrenia and neurodevelopmental disorders. Biological Psychiatry 96(5), pp. 376-389. (10.1016/j.biopsych.2024.03.011)
- Legge, S. E. et al. 2024. Genetic and phenotypic features of Schizophrenia in the UK Biobank. JAMA Psychiatry 81, pp. 681-690. (10.1001/jamapsychiatry.2024.0200)
- Trastulla, L. et al. 2024. Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications 15, article number: 5534. (10.1038/s41467-024-49338-2)
- Frei, O. et al. 2024. Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets. Nature Genetics 56, pp. 1310-1318. (10.1038/s41588-024-01771-1)
- D'Andrea, G. et al. 2024. Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study. Psychological Medicine 54(8), pp. 1810-1823. (10.1017/S0033291723003781)
- Owen, M. and O'Donovan, M. 2024. The genetics of cognition in schizophrenia.. Brain Medicine
- Stevenson-Hoare, J. et al. 2024. Severe psychiatric disorders are associated with increased risk of dementia. BMJ Mental Health 27(1), article number: e301097. (10.1136/bmjment-2024-301097)
- Clifton, N. E., Lin, J. Q., Holt, C. E., O’Donovan, M. C. and Mill, J. 2024. Enrichment of the local synaptic translatome for genetic risk associated with schizophrenia and autism spectrum disorder. Biological Psychiatry 95(9), pp. 888-895. (10.1016/j.biopsych.2023.12.006)
- van der Meer, D. et al. 2024. Clustering schizophrenia genes by their temporal expression patterns aids functional interpretation. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders 50(2), pp. 327-338. (10.1093/schbul/sbad140)
- Kappel, D. et al. 2024. Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia. European Neuropsychopharmacology 80, pp. 47-54. (10.1016/j.euroneuro.2023.12.007)
- Shakeshaft, A., Martin, J., Dennison, C. A., Riglin, L., Lewis, C. M., O'Donovan, M. and Thapar, A. 2024. Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems. Molecular Psychiatry 29, pp. 238-246. (10.1038/s41380-023-02319-1)
- Dennison, C. et al. 2024. Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry. Journal of Child Psychology and Psychiatry 65(1), pp. 42-51. (10.1111/jcpp.13862)
- Schipper, M., Leeuw, C., Maciel, B., Wightman, H., Boomsma, D., O’Donovan, M. and Posthuma, D. 2024. Gene prioritization in GWAS loci using multimodal evidence. Nature Genetics
- O'Connell, K. et al. 2024. Genomics yields biological and phenotypic insights into bipolar disorder. Biological Psychiatry
- Owen, M. J. and O'Donovan, M. C. 2024. The genetics of cognition in schizophrenia. Genomic Psychiatry (10.61373/gp024i.0040)
2023
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Spinazzola, E. et al. 2023. The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case-control study. Psychological Medicine 53(15), pp. 7418-7427. (10.1017/S0033291723001071)
- Yuan, K. et al. 2023. Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases. European Neuropsychopharmacology 75(Supp 1), pp. S6-S7. (10.1016/j.euroneuro.2023.08.021)
- Lock, S. K. et al. 2023. Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count. Schizophrenia 9, article number: 74. (10.1038/s41537-023-00404-6)
- Toste, C., O'Donovan, M. and Bray, N. 2023. Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits. Human Molecular Genetics 32(20), pp. 2941-2949., article number: ddad118. (10.1093/hmg/ddad118)
- Doherty, A., O'Donovan, M., Hamshere, M., Jones, I., Owen, M. and Walters, J. 2023. Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors. The American Journal of Psychiatry 180(10), pp. 723-738. (10.1176/appi.ajp.21121266)
- Clifton, N., Schulmann, A., Schizophrenia Working Group of the Psychiatric Genomics Consorti, ., Holmans, P., O'Donovan, M. and Vawter, M. 2023. The relationship between case-control differential gene expression from brain tissue and genetic associations in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 192(5-6), pp. 85-92. (10.1002/ajmg.b.32931)
- Owen, M., Legge, S., Rees, E., Walters, J. and O'Donovan, M. 2023. Genomic findings in schizophrenia and their implications. Molecular Psychiatry 28, pp. 3638-3647. (10.1038/s41380-023-02293-8)
- Le Guen, Y. et al. 2023. Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences 120(36), article number: e2302720120. (10.1073/pnas.2302720120)
- Ollà, I. et al. 2023. Pathogenic mis-splicing of CPEB4 in schizophrenia. Biological Psychiatry 94(4), pp. 341-351. (10.1016/j.biopsych.2023.03.010)
- Maury, E. A. et al. 2023. Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions. Cell Genomics 3(8), article number: 100356. (10.1016/j.xgen.2023.100356)
- Allardyce, J. et al. 2023. Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data. The Lancet Psychiatry 10(8), pp. 623-631. (10.1016/S2215-0366(23)00186-4)
- Lewis, K. et al. 2023. The dynamic interplay between sleep and mood: an intensive longitudinal study of individuals with bipolar disorder. Psychological Medicine 53(8), pp. 3345-3354. (10.1017/S0033291721005377)
- Rodriguez, V. et al. 2023. Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study. Psychological Medicine 53(8), pp. 3396-3405. (10.1017/S0033291721005456)
- Demontis, D. et al. 2023. Author Correction: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nature Genetics 55, article number: 730. (10.1038/s41588-023-01350-w)
- Johnson, E. C. et al. 2023. Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder. Psychological Medicine 53(4), pp. 1196-1204. (10.1017/S003329172100266X)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Pardinas, A. F. et al. 2023. Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring data. The Lancet Psychiatry 10(3), pp. 209-219. (10.1016/S2215-0366(23)00002-0)
- Dimitriadis, S. I. et al. 2023. Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk. Cerebral Cortex 33(6), pp. 2997-3011. (10.1093/cercor/bhac256)
- Liu, D. et al. 2023. Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics 55, pp. 369-376. (10.1038/s41588-023-01305-1)
- Demontis, D. et al. 2023. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nature Genetics 55, pp. 198-208. (10.1038/s41588-022-01285-8)
- Ajnakina, O. et al. 2023. Development and validation of predictive model for a diagnosis of first episode psychosis using the multinational EU-GEI case-control study and modern statistical learning methods.. Schizophrenia Bulletin Open 4(1), article number: sgad008. (10.1093/schizbullopen/sgad008)
- Cameron, D. et al. 2023. Single nuclei RNA sequencing of 5 regions of the human prenatal brain implicates developing neuron populations in genetic risk for schizophrenia. Biological Psychiatry 93, pp. 157-166. (10.1016/j.biopsych.2022.06.033)
- Kappel, D. B. et al. 2023. Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores. Biological Psychiatry 93, pp. 149-156. (10.1016/j.biopsych.2022.07.014)
- Martin, J. et al. 2023. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biological Psychiatry 93(1), pp. 37-44. (10.1016/j.biopsych.2022.06.008)
2022
- Crawford, K. et al. 2022. Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing. Molecular Psychiatry (10.1038/s41380-022-01926-8)
- Riglin, L. et al. 2022. Early manifestations of genetic liability for ADHD, autism and schizophrenia at ages 18 and 24 months. JCPP Advances 2(3), article number: e12093. (10.1002/jcv2.12093)
- Bracher-Smith, M. et al. 2022. Machine learning for prediction of schizophrenia using genetic and demographic factors in the UK Biobank. Schizophrenia Research 246, pp. 156-164. (10.1016/j.schres.2022.06.006)
- Richards, A. et al. 2022. Genetic liabilities differentiating bipolar disorder, schizophrenia and major depression and phenotypic heterogeneity in bipolar disorder. JAMA Psychiatry 79(10), pp. 1032-1039. (10.1001/jamapsychiatry.2022.2594)
- Creeth, H. D. J. et al. 2022. Ultrarare coding variants and cognitive function in schizophrenia. JAMA Psychiatry 79(10), pp. 963-970. (10.1001/jamapsychiatry.2022.2289)
- Riglin, L. et al. 2022. “Late-onset” ADHD symptoms in young adulthood: is this the same as child-onset ADHD?. Journal of Attention Disorders 26(10), pp. 1271-1282. (10.1177/10870547211066486)
- Paquin, V. et al. 2022. Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population. Social Psychiatry and Psychiatric Epidemiology (10.1007/s00127-022-02346-3)
- van Os, J. et al. 2022. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway. Psychological Medicine 52(10), pp. 1910-1922. (10.1017/S0033291720003748)
- Henquet, C. et al. 2022. A replication study of JTC bias, genetic liability for psychosis and delusional ideation. Psychological Medicine 52(9), pp. 1777-1783. (10.1017/S0033291720003578)
- Crawford, K. et al. 2022. Analysis of Alzheimer's disease Polygenic Risk Scores using RNA-sequencing provides further novel biological pathways. [Online]. medRxiv: Cold Spring Harbor Laboratory. (10.1101/2022.06.29.22276952) Available at: https://doi.org/10.1101/2022.06.29.22276952
- Morris, E., O'Donovan, M., Virani, A. and Austin, J. 2022. An ethical analysis of divergent clinical approaches to the application of genetic testing for autism and schizophrenia. Human Genetics 141, pp. 1069-1084. (10.1007/s00439-021-02349-1)
- Palmer, D. et al. 2022. Exome sequencing in bipolar disorder reveals AKAP11 as a risk gene shared with schizophrenia. Nature Genetics (10.1038/s41588-022-01034-x)
- Bellenguez, C. et al. 2022. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics 54(4), pp. 412-436. (10.1038/s41588-022-01024-z)
- Trubetskoy, V. et al. 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604, pp. 502-508. (10.1038/s41586-022-04434-5)
- Singh, T., Schizophrenia Exome Meta-Analysis (SCHEMA) Consortium, ., Kirov, G., Rees, E., Walters, J., Owen, M. and O'Donovan, M. 2022. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature 604, pp. 509-516. (10.1038/s41586-022-04556-w)
- Lancaster, T., Dimitriadis, S., Perry, G., Zammit, S., O'Donovan, M. and Linden, D. 2022. Morphometric analysis of structural MRI using schizophrenia meta-analytic priors distinguish patients from controls in two independent samples and in a sample of individuals with high polygenic risk. Schizophrenia Bulletin 48(2), pp. 524-532., article number: sbab125. (10.1093/schbul/sbab125)
- Fusar-Poli, L. et al. 2022. Examining facial emotion recognition as an intermediate phenotype for psychosis: findings from the EUGEI study. Progress in Neuro-Psychopharmacology and Biological Psychiatry 113, article number: 110440. (10.1016/j.pnpbp.2021.110440)
- Mullins, N. et al. 2022. Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors. Biological Psychiatry 91(3), pp. 313-327. (10.1016/j.biopsych.2021.05.029)
- Jones, H. J. et al. 2022. Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence. Psychological Medicine 52(1), pp. 132-139. (10.1017/S0033291720001798)
- Vassos, E. et al. 2022. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin 48(1), pp. 20-26. (10.1093/schbul/sbab052)
- Sanders, B. et al. 2022. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature Communications 13(1), article number: 27. (10.1038/s41467-021-27601-0)
- Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79(3), pp. 260-269. (10.1001/jamapsychiatry.2021.3799)
2021
- Dimitriadis, S. I. et al. 2021. Global brain flexibility during working memory is reduced in a high genetic risk group for schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 6(12), pp. 1176-1184. (10.1016/j.bpsc.2021.01.007)
- Di Florio, A. et al. 2021. Post-partum psychosis and its association with bipolar disorder in the UK: a case-control study using polygenic risk scores. The Lancet Psychiatry 8(12), pp. 1045-1052. (10.1016/S2215-0366(21)00253-4)
- Kalman, J. L. et al. 2021. Characterisation of age and polarity at onset in bipolar disorder. The British Journal of Psychiatry 219(6), pp. 659-669. (10.1192/bjp.2021.102)
- Ajnakina, O. et al. 2021. Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results from the multi-center EU-GEI study. Schizophrenia Bulletin 47(6), pp. 1653-1662. (10.1093/schbul/sbab055)
- Dimitriadis, S. I. et al. 2021. Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk. Translational Psychiatry 11, article number: 592. (10.1038/s41398-021-01678-z)
- Martin, J. et al. 2021. Sex differences in anxiety and depression in children with ADHD investigating genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(7), pp. 412-422. (10.1002/ajmg.b.32842)
- Jia, X. et al. 2021. Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder. Molecular Psychiatry 26, pp. 5239-5250. (10.1038/s41380-020-01006-9)
- Dennison, C. et al. 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47(5), pp. 1375-1384. (10.1093/schbul/sbab036)
- Clifton, N. E. et al. 2021. Developmental profile of psychiatric risk associated with voltage-gated cation channel activity. Biological Psychiatry 90(6) (10.1016/j.biopsych.2021.03.009)
- Rees, E. et al. 2021. Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations. Nature Communications 12, article number: 5353. (10.1038/s41467-021-25532-4)
- Martin, J. et al. 2021. Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression. PLoS ONE 16(9), article number: e0248254. (10.1371/journal.pone.0248254)
- Riglin, L. et al. 2021. ADHD and depression: investigating a causal explanation. Psychological Medicine 51(11), pp. 1890-1897. (10.1017/S0033291720000665)
- Quattrone, D. et al. 2021. The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study. Translational Psychiatry 11(1), article number: 423. (10.1038/s41398-021-01526-0)
- Legge, S. et al. 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78(10), pp. 1143-1151. (10.1001/jamapsychiatry.2021.1961)
- Clifton, N. E. et al. 2021. Genetic association of FMRP targets with psychiatric disorders. Molecular Psychiatry 26, pp. 2977-2990. (10.1038/s41380-020-00912-2)
- Hubbard, L. et al. 2021. Rare copy number variations are associated with poorer cognition in schizophrenia. Biological Psychiatry 90(1), pp. 28-34. (10.1016/j.biopsych.2020.11.025)
- Byrne, E. et al. 2021. Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders. Molecular Psychiatry 26, pp. 2070-2081. (10.1038/s41380-020-0705-9)
- Hall, L. S. et al. 2021. Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders. Molecular Psychiatry 26, pp. 2082-2088. (10.1038/s41380-020-0743-3)
- Amare, A. T. et al. 2021. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry 26, pp. 2457-2470. (10.1038/s41380-020-0689-5)
- Tigaret, C. M. et al. 2021. Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c. Molecular Psychiatry 26, pp. 1748-1760. (10.1038/s41380-020-01001-0)
- Mullins, N. et al. 2021. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics 53, pp. 817-829. (10.1038/s41588-021-00857-4)
- Peterson, R. E. et al. 2021. Genome-wide analyses of smoking behaviors in schizophrenia: findings from the Psychiatric Genomics Consortium. Journal of Psychiatric Research 137, pp. 215-225. (10.1016/j.jpsychires.2021.02.027)
- Riglin, L. et al. 2021. Investigating attention‐deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life?. Journal of Child Psychology and Psychiatry 62(4), pp. 449-457. (10.1111/jcpp.13297)
- Willcocks, I. et al. 2021. Clozapine metabolism is associated with absolute neutrophil count in individuals with treatment-resistant schizophrenia. Frontiers in Pharmacology 12, article number: 658734. (10.3389/fphar.2021.658734)
- Konte, B. et al. 2021. HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry. Translational Psychiatry 11, article number: 214. (10.1038/s41398-021-01322-w)
- Tripoli, G. et al. 2021. Jumping to conclusions, general intelligence, and psychosis liability: findings from the multi-centre EU-GEI case-control study. Psychological Medicine 51(4), pp. 623-633. (10.1017/S003329171900357X)
- Dennison, C. A. et al. 2021. Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank. PLoS ONE 16(3), article number: e0249189. (10.1371/journal.pone.0249189)
- Erzin, G. et al. 2021. Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. European Psychiatry 64(1), article number: e25. (10.1192/j.eurpsy.2021.19)
- Smeland, O. B. et al. 2021. Genome-wide association analysis of Parkinson's disease and schizophrenia reveals shared genetic architecture and identifies novel risk loci. Biological Psychiatry 89(3), pp. 227-235. (10.1016/j.biopsych.2020.01.026)
- Owen, M. J. and O'Donovan, M. C. 2021. Large-scale genomics: a paradigm shift in psychiatry?. Biological Psychiatry 89, pp. 5-7. (10.1016/j.biopsych.2020.01.017)
- Hannon, E. et al. 2021. DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. eLife 10, article number: e58430. (10.7554/eLife.58430)
- Chauquet, S., Zhu, Z., O'Donovan, M., Walters, J., Wray, N. and Shah, S. 2021. Investigating the potential effects of antihypertensive medication on psychiatric disorders: a mendelian randomisation study. JAMA Psychiatry 78(6), pp. 623-631. (10.1001/jamapsychiatry.2021.0005)
- Hasmi, L. et al. 2021. What makes the psychosis 'clinical high risk' state risky: psychosis itself or the co-presence of a non-psychotic disorder?. Epidemiology and Psychiatric Sciences 30, article number: e53. (10.1017/S204579602100041X)
2020
- Pries, L. et al. 2020. Association of recent stressful life events with mental and physical health in the context of genomic and exposomic liability for schizophrenia. JAMA Psychiatry 77(12), pp. 1296-1304. (10.1001/jamapsychiatry.2020.2304)
- Ward, J. et al. 2020. The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry 25, pp. 3091-3099. (10.1038/s41380-019-0439-8)
- Pries, L. et al. 2020. Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum. Epidemiology and Psychiatric Sciences 29, article number: e182. (10.1017/S2045796020000943)
- Kendall, K. M. et al. 2020. Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: a data linkage study. BJPsych Open 6(6), article number: e139. (10.1192/bjo.2020.42)
- Legge, S. E. et al. 2020. The Duffy-null genotype and risk of infection. Human Molecular Genetics 29(20), pp. 3341-3349. (10.1093/hmg/ddaa208)
- Jones, H. J. et al. 2020. A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 183(6), pp. 360-369. (10.1002/ajmg.b.32808)
- van Os, J. et al. 2020. Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study. Psychological Medicine 50(11), pp. 1884-1897. (10.1017/S003329171900196X)
- Wong, H., Wadon, M., Evans, A., Kirov, G., Modi, N., O'Donovan, M. and Thapar, A. 2020. Contribution of de novo and inherited rare copy number variants to very preterm birth. Journal of Medical Genetics 57(8), pp. 552-557. (10.1136/jmedgenet-2019-106619)
- Riglin, L. et al. 2020. Using genetics to examine a general liability to childhood psychopathology. Behavior Genetics 50, pp. 213-220. (10.1007/s10519-019-09985-4)
- Coleman, J. R. I. et al. 2020. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry 25, pp. 1430-1446. (10.1038/s41380-019-0546-6)
- Akingbuwa, W. A. et al. 2020. Genetic associations between childhood psychopathology and adult depression and associated traits in 42 998 individuals. JAMA Psychiatry 77(7), pp. 715-728. (10.1001/jamapsychiatry.2020.0527)
- Wong, H. S., Hopkins, L., O'Donovan, M. C., Thapar, A. and Modi, N. 2020. Pilot study to establish a prospective neonatal cohort: Study of Preterm Infants and Neurodevelopmental Genes (SPRING). Molecular Psychiatry 4(1), article number: e000648. (10.1136/bmjpo-2020-000648)
- Lee, S. C. et al. 2020. Area deprivation, urbanicity, severe mental illness and social drift — a population-based linkage study using routinely collected primary and secondary care data. Schizophrenia Research 220, pp. 130-140. (10.1016/j.schres.2020.03.044)
- Legge, S. et al. 2020. Clinical indicators of treatment-resistant psychosis. British Journal of Psychiatry 216(5), pp. 259-266. (10.1192/bjp.2019.120)
- Wadon, M., Modi, N., Wong, H., Thapar, A. and O'Donovan, M. 2020. Recent advances in the genetics of preterm birth. Annals of Human Genetics 84(3), pp. 205-213. (10.1111/ahg.12373)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
- Foley, C. et al. 2020. Identifying schizophrenia patients who carry pathogenic genetic copy number variants using standard clinical assessment: retrospective cohort study. British Journal of Psychiatry 216(5), pp. 275-279. (10.1192/bjp.2019.262)
- Szatkiewicz, J. P. et al. 2020. Characterization of single gene copy number variants in schizophrenia. Biological Psychiatry 87(8), pp. 736-744. (10.1016/j.biopsych.2019.09.023)
- Sullivan, S. A. et al. 2020. A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder. American Journal of Psychiatry 177(4), pp. 308-317. (10.1176/appi.ajp.2019.19060654)
- Richards, A. et al. 2020. The relationship between polygenic risk scores and cognition in schizophrenia. Schizophrenia Bulletin 46(2), pp. -. (10.1093/schbul/sbz061)
- Lewis, K. J. et al. 2020. Comparison of genetic liability for sleep traits among individuals with Bipolar Disorder I or II and control participants. JAMA Psychiatry 77(3), pp. 303-310. (10.1001/jamapsychiatry.2019.4079)
- Glanville, K. P. et al. 2020. Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated with depression. Biological Psychiatry 87(5), pp. 419-430. (10.1016/j.biopsych.2019.06.031)
- Rees, E. et al. 2020. De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia. Nature Neuroscience 23(2), pp. 179-184. (10.1038/s41593-019-0565-2)
- Hall, L. S. et al. 2020. A transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia. Human Molecular Genetics 29(1), pp. 159-167. (10.1093/hmg/ddz253)
2019
- Legge, S. E. et al. 2019. Association of genetic liability to psychotic experiences with neuropsychotic disorders and traits. JAMA Psychiatry 76(12), pp. 1256-1265. (10.1001/jamapsychiatry.2019.2508)
- Lam, M. et al. 2019. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics 51, pp. 1670-1678. (10.1038/s41588-019-0512-x)
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Escott-Price, V. et al. 2019. Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort. Psychological Medicine 49(15), pp. 2499-2504. (10.1017/S0033291718000454)
- Chapman, R. M. et al. 2019. Convergent evidence that ZNF804A is a regulator of pre-messenger RNA processing and gene expression. Schizophrenia Bulletin 45(6), pp. 1267-1278. (10.1093/schbul/sby183)
- Toste, C. et al. 2019. No effect of genome-wide significant schizophrenia risk variation at the DRD2 locus on the allelic expression of DRD2 in post-mortem striatum. Molecular Neuropsychiatry 5(4), pp. 212-217. (10.1159/000501022)
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45(5), pp. 1024-1032. (10.1093/schbul/sby146)
- Pries, L. et al. 2019. Estimating exposome score for schizophrenia using predictive modeling approach in two independent samples: the results from the EUGEI study. Schizophrenia Bulletin 45(5), pp. 960-965. (10.1093/schbul/sbz054)
- Pain, O. et al. 2019. Novel insight into the etiology of autism spectrum disorder gained by integrating expression data with genome-wide association statistics. Biological Psychiatry 86(4), pp. 265-273. (10.1016/j.biopsych.2019.04.034)
- Mulllins, N. et al. 2019. GWAS of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores. American Journal of Psychiatry 176(8), pp. 651-660. (10.1176/appi.ajp.2019.18080957)
- Riglin, L. et al. 2019. Identifying novel types of irritability using a developmental genetic approach. American Journal of Psychiatry 176(8), pp. 635-642. (10.1176/appi.ajp.2019.18101134)
- Escott-Price, V., Pardinas, A. F., Santiago, E., Walters, J., Kirov, G., Owen, M. J. and O'Donovan, M. C. 2019. The relationship between common variant schizophrenia liability and number of offspring in the UK Biobank. American Journal of Psychiatry 176(8), pp. 661-666. (10.1176/appi.ajp.2018.18020140)
- Romagnoni, A. et al. 2019. Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data. Scientific Reports 9(1), pp. -., article number: 10351. (10.1038/s41598-019-46649-z)
- Czamara, D. et al. 2019. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications 10, article number: 2548. (10.1038/s41467-019-10461-0)
- Quattrone, D. et al. 2019. Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU GEI study. Psychological Medicine 49(8), pp. 1378-1391. (10.1017/S0033291718002131)
- Pardinas, A. F. et al. 2019. Pharmacogenomic variants and drug interactions identified through the genetic analysis of clozapine metabolism. American Journal of Psychiatry 176(6), pp. 477-486. (10.1176/appi.ajp.2019.18050589)
- Guloksuz, S. et al. 2019. Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study. World Psychiatry 18(2), pp. 173-182. (10.1002/wps.20629)
- Stahl, E. A. et al. 2019. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics 51, pp. 793-803. (10.1038/s41588-019-0397-8)
- Kendall, K. M. et al. 2019. Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank. British Journal of Psychiatry 214(5), pp. 297-304. (10.1192/bjp.2018.301)
- Huckins, L. M. et al. 2019. Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics 51, pp. 659-674. (10.1038/s41588-019-0364-4)
- Kendall, K. M. et al. 2019. Association of rare copy number variants with risk of depression. JAMA Psychiatry 76(8), pp. 818-825. (10.1001/jamapsychiatry.2019.0566)
- Gorman, K. M. et al. 2019. Bi-allelic loss-of-function CACNA1B mutations in progressive epilepsy-dyskinesia. American Journal of Human Genetics 104(5), pp. 948-956. (10.1016/j.ajhg.2019.03.005)
- Rees, E. et al. 2019. Targeted sequencing of 10,198 samples confirms abnormalities in neuronal activity and implicates voltage-gated sodium channels in schizophrenia pathogenesis. Biological Psychiatry 85(7), pp. 554-562. (10.1016/j.biopsych.2018.08.022)
- Harold, D. et al. 2019. Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180(3), pp. 223-231. (10.1002/ajmg.b.32716)
- Lancaster, T. M. et al. 2019. Structural and functional neuroimaging of polygenic risk for schizophrenia: a recall-by-genotype-based approach. Schizophrenia Bulletin 45(2), pp. 405-414. (10.1093/schbul/sby037)
- Rice, F., Riglin, L., Thapar, A. K., Heron, J., Anney, R., O'Donovan, M. C. and Thapar, A. 2019. Characterizing developmental trajectories and the role of neuropsychiatric genetic risk variants in early-onset depression. JAMA Psychiatry 76(3), pp. 306-313. (10.1001/jamapsychiatry.2018.3338)
- Legge, S. E. et al. 2019. A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia. Molecular Psychiatry 24, pp. 328-337. (10.1038/s41380-018-0335-7)
- Kunkle, B. W. et al. 2019. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics 51(3), pp. 414-430. (10.1038/s41588-019-0358-2)
- O'Brien, H. et al. 2019. Sex differences in gene expression in the human fetal brain. [Online]. bioRxiv. (10.1101/483636) Available at: https://doi.org/10.1101/483636
- Richards, A. et al. 2019. Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a New Zealand longitudinal population cohort study. British Journal of Psychiatry 214(2), pp. 96-102. (10.1192/bjp.2018.227)
- Crawford, K. et al. 2019. Medical consequences of pathogenic CNVs in adults: Analysis of the UK Biobank. Journal of Medical Genetics 56, pp. 131-138. (10.1136/jmedgenet-2018-105477)
- Clifton, N. E. et al. 2019. Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry 9, article number: 74. (10.1038/s41398-019-0405-x)
- Kopczynska, M. et al. 2019. Complement system biomarkers in first episode psychosis. Schizophrenia Research 204, pp. 16-22. (10.1016/j.schres.2017.12.012)
- Escott-Price, V., Bracher-Smith, M., Menzies, G., Walters, J., Kirov, G., Owen, M. J. and O'Donovan, M. C. 2019. Genetic liability to schizophrenia is negatively associated with educational attainment in UK Biobank. Journal of Molecular Psychiatry, pp. -. (10.1038/s41380-018-0328-6)
- Vivian-Griffiths, T. et al. 2019. Predictive modeling of schizophrenia from genomic data: Comparison of polygenic risk score with kernel support vector machines approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180(1), pp. 80-85. (10.1002/ajmg.b.32705)
- Riglin, L. et al. 2019. Developmental contributions of schizophrenia risk alleles and childhood peer victimization to early-onset mental health trajectories. American Journal of Psychiatry 176(1), pp. 36-43. (10.1176/appi.ajp.2018.18010075)
- Bergen, S. E. et al. 2019. Joint contributions of rare copy number variants and common SNPs to risk for schizophrenia. American Journal of Psychiatry 176(1), pp. 29-35. (10.1176/appi.ajp.2018.17040467)
- Niarchou, M. et al. 2019. Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits. Translational Psychiatry 10, article number: 51. (10.1038/s41398-020-0688-y)
2018
- Arnau-Soler, A. et al. 2018. Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE 13(12), article number: e0209160. (10.1371/journal.pone.0209160)
- Li, M. et al. 2018. Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science 362(6420), article number: eaat7615. (10.1126/science.aat7615)
- Owen, D. et al. 2018. Effects of pathogenic CNVs on physical traits in participants of the UK Biobank. BMC Genomics 19(1), article number: 867. (10.1186/s12864-018-5292-7)
- O'Brien, H. E. et al. 2018. Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome Biology 19, article number: 194. (10.1186/s13059-018-1567-1)
- Riglin, L. et al. 2018. The impact of schizophrenia and mood disorder risk alleles on emotional problems: investigating change from childhood to middle age. Psychological Medicine 48(13), pp. 2153-2158. (10.1017/S0033291717003634)
- Cooper, M. et al. 2018. Investigating late-onset ADHD: a population cohort investigation. Journal of Child Psychology and Psychiatry 59(10), pp. 1105-1113. (10.1111/jcpp.12911)
- Bray, N. J. and O'Donovan, M. C. 2018. The genetics of neuropsychiatric disorders. Brain and Neuroscience Advances 2, pp. 1-6. (10.1177/2398212818799271)
- Strawbridge, R. J. et al. 2018. Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry 8(1), article number: 178. (10.1038/s41398-018-0236-1)
- John, A. et al. 2018. Premature mortality among people with severe mental illness - new evidence from linked primary care data. Schizophrenia Research 199, pp. 154-162. (10.1016/j.schres.2018.04.009)
- Jones, H. J. et al. 2018. Investigating the genetic architecture of general and specific psychopathology in adolescence. Translational Psychiatry 8(1), article number: 145. (10.1038/s41398-018-0204-9)
- Fabbri, C. et al. 2018. Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies. European Neuropsychopharmacology 28(8), pp. 945-954. (10.1016/j.euroneuro.2018.05.009)
- Donohoe, G. et al. 2018. Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation. Psychological Medicine 48(10), pp. 1608-1615. (10.1017/S0033291717002987)
- Guyatt, A. L. et al. 2018. Association of copy number variation across the genome with neuropsychiatric traits in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(5), pp. 489-502. (10.1002/ajmg.b.32637)
- Skene, N. G. et al. 2018. Genetic identification of brain cell types underlying schizophrenia. Nature Genetics 50, pp. 825-833. (10.1038/s41588-018-0129-5)
- Baker, E., Schmidt, K. M., Sims, R., O'Donovan, M. C., Williams, J., Holmans, P. and Escott-Price, V. 2018. POLARIS: polygenic LD-adjusted risk score approach for set-based analysis of GWAS data. Genetic Epidemiology 42(4), pp. 366-377. (10.1002/gepi.22117)
- Martin, J. et al. 2018. A genetic investigation of sex bias in the prevalence of attention-deficit/hyperactivity disorder. Biological Psychiatry 83(12), pp. 1044-1053. (10.1016/j.biopsych.2017.11.026)
- Ruderfer, D. M. et al. 2018. Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. Cell 173(7), pp. 1705-1715.e16. (10.1016/j.cell.2018.05.046)
- Leonenko, G. et al. 2018. A data-driven investigation of relationships between bipolar psychotic symptoms and schizophrenia genome-wide significant genetic loci. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(4), pp. 468-475. (10.1002/ajmg.b.32635)
- Wray, N. R. et al. 2018. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics 50(5), pp. 668-681. (10.1038/s41588-018-0090-3)
- Gusev, A. et al. 2018. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nature Genetics 50, pp. 538-548. (10.1038/s41588-018-0092-1)
- Sims, R. et al. 2018. Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing. [Online]. bioRxiv. (10.1101/294629) Available at: https://doi.org/10.1101/294629
- Cosgrove, D. et al. 2018. Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(3), pp. 369-376. (10.1002/ajmg.b.32620)
- Pardinas, A. F. et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics 50, pp. 381-389. (10.1038/s41588-018-0059-2)
- Strawbridge, R. J. et al. 2018. Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry 8, article number: 39. (10.1038/s41398-017-0079-1)
- Allardyce, J. et al. 2018. Association between schizophrenia-related polygenic liability and the occurrence and level of mood-incongruent psychotic symptoms in bipolar disorder. JAMA Psychiatry 75(1), pp. 28-35. (10.1001/jamapsychiatry.2017.3485)
2017
- Green, E. K. et al. 2017. Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(8), pp. 767-771. (10.1002/ajmg.b.32572)
- Cosgrove, D. et al. 2017. Cognitive characterization of schizophrenia risk variants involved in synaptic transmission: evidence of CACNA1C's role in working memory. Neuropsychopharmacology 42, pp. 2612-2622. (10.1038/npp.2017.123)
- Ward, J. et al. 2017. Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with MDD, anxiety disorder and schizophrenia. Translational Psychiatry 7, article number: 1264. (10.1038/s41398-017-0012-7)
- Li, Z. et al. 2017. Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nature Genetics 49, pp. 1576-1583. (10.1038/ng.3973)
- Leonenko, G. et al. 2017. Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(7), pp. 724-731. (10.1002/ajmg.b.32560)
- Legge, S. E. et al. 2017. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Molecular Psychiatry 22, pp. 1502-1508. (10.1038/mp.2016.97)
- Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
- Sims, R. et al. 2017. Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics 49, pp. 1373-1384. (10.1038/ng.3916)
- Direk, N. et al. 2017. An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype. Biological Psychiatry 82(5), pp. 322-329. (10.1016/j.biopsych.2016.11.013)
- Leonenko, G. et al. 2017. Investigation of relationships between bipolar disorder phenotypes and genome-wide significant loci from PGC2 schizophrenia. European Neuropsychopharmacology 27(S3), pp. S383-S384. (10.1016/j.euroneuro.2016.09.416)
- Singh, T. et al. 2017. The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability. Nature Genetics 49, pp. 1167-1173. (10.1038/ng.3903)
- Kendall, K. M. et al. 2017. Cognitive performance among carriers of pathogenic copy number variants: analysis of 152,000 UK Biobank subjects. Biological Psychiatry 82(2), pp. P103-110. (10.1016/j.biopsych.2016.08.014)
- Hendricks, A. E. et al. 2017. Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity. Scientific Reports 7, article number: 4394. (10.1038/s41598-017-03054-8)
- Witt, S. H. et al. 2017. Genome-wide association study of borderline personality disorder reveals genetic overlap with the bipolar disorder, schizophrenia and major depression. Translational Psychiatry 7, article number: e1155.
- Hannon, E., Weedon, M., Bray, N., O'Donovan, M. and Mill, J. 2017. Pleiotropic effects of trait-associated genetic variation on DNA methylation: utility for refining GWAS loci. American Journal of Human Genetics 100(6), pp. 954-959. (10.1016/j.ajhg.2017.04.013)
- García-González, J. et al. 2017. Pharmacogenetics of antidepressant response: a polygenic approach. Progress in Neuro-Psychopharmacology and Biological Psychiatry 75, pp. 128-134. (10.1016/j.pnpbp.2017.01.011)
- McLaughlin, R. L. et al. 2017. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications 8, article number: 14774. (10.1038/ncomms14774)
- Riglin, L., Collishaw, S., Richards, A., Thapar, A., Maughan, B., O'Donovan, M. C. and Thapar, A. 2017. Schizophrenia polygenic risk score and psychotic risk detection - authors' reply. The Lancet Psychiatry 4(3), pp. 188-189. (10.1016/S2215-0366(17)30052-4)
- Clifton, N. E. et al. 2017. Schizophrenia copy number variants and associative learning. Molecular Psychiatry 22(2), pp. 178-182. (10.1038/mp.2016.227)
- Marshall, C. R. et al. 2017. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics 49, pp. 27-35. (10.1038/ng.3725)
- Lo, M. et al. 2017. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics 49, pp. 152-156. (10.1038/ng.3736)
- Cosgrove, D. et al. 2017. MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls. Translational Psychiatry 7(1), pp. e1012. (10.1038/tp.2016.286)
- Giegling, I. et al. 2017. Genetics of schizophrenia: A consensus paper of the WFSBP task force on genetics. World Journal of Biological Psychiatry 18(7), pp. 492-505. (10.1080/15622975.2016.1268715)
- Fabbri, C. et al. 2017. Consensus paper of the WFSBP Task Force on Genetics: genetics, epigenetics and gene expression markers of major depressive disorder and antidepressant response. World Journal of Biological Psychiatry 18(1), pp. 5-28. (10.1080/15622975.2016.1208843)
- Fraguas, D., Díaz-Caneja, C. M., State, M. W., O'Donovan, M. C., Gur, R. E. and Arango, C. 2017. Mental disorders of known aetiology and precision medicine in psychiatry: a promising but neglected alliance [Editorial]. Psychological Medicine 47(2), pp. 193-197. (10.1017/S0033291716001355)
- Riglin, L., Collishaw, S., Richards, A., Thapar, A. K., Maughan, B., O'Donovan, M. C. and Thapar, A. 2017. Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study. Lancet Psychiatry 4(1), pp. 57-62. (10.1016/S2215-0366(16)30406-0)
- Sullivan, P. F. et al. 2017. Psychiatric genomics: an update and an agenda. American Journal of Psychiatry 175(1), pp. 15-27. (10.1176/appi.ajp.2017.17030283)
2016
- Riglin, L. et al. 2016. Association of genetic risk variants with attention-deficit/hyperactivity disorder trajectories in the general population. JAMA Psychiatry 73(12), pp. 1285-1292. (10.1001/jamapsychiatry.2016.2817)
- Whitton, L. et al. 2016. Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(8), pp. 1170-1179. (10.1002/ajmg.b.32503)
- Rees, E. et al. 2016. Analysis of intellectual disability copy number variants for association with schizophrenia. JAMA Psychiatry 73(9), pp. 963-969. (10.1001/jamapsychiatry.2016.1831)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Tansey, K. E. et al. 2016. Common alleles contribute to schizophrenia in CNV carriers. Molecular Psychiatry 21, pp. 1085-1089. (10.1038/mp.2015.143)
- Pardinas, A. et al. 2016. Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection. [Online]. bioRxiv. (10.1101/068593) Available at: http://dx.doi.org/10.1101/068593
- Smith, D. J. et al. 2016. Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci. Molecular Psychiatry 21, pp. 749-757. (10.1038/mp.2016.49)
- Martin, J. et al. 2016. Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study. American Journal of Epidemiology 183(12), pp. 1149-1158. (10.1093/aje/kww009)
- Legge, S. et al. 2016. Reasons for discontinuing clozapine: a cohort study of patients commencing treatment. Schizophrenia Research 174, pp. 113-119. (10.1016/j.schres.2016.05.002)
- Han, J. et al. 2016. Gender differences in CNV burden do not confound schizophrenia CNV associations. Scientific Reports 6, article number: 25986. (10.1038/srep25986)
- Isles, A. R. et al. 2016. Parental origin of interstitial duplications at 15q11.2-q13.3 in schizophrenia and neurodevelopmental disorders. PLoS Genetics 12(5), article number: e1005993. (10.1371/journal.pgen.1005993)
- Singh, T. et al. 2016. Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders. Nature Neuroscience 19(4), pp. 571-577. (10.1038/nn.4267)
- van Goozen, S. H. M. et al. 2016. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. Journal of Child Psychology and Psychiatry 57(4), pp. 472-480. (10.1111/jcpp.12464)
- Lawrie, S. M., O'Donovan, M. C., Saks, E., Burns, T. and Lieberman, J. A. 2016. Towards diagnostic markers for the psychoses. The Lancet Psychiatry 3(4), pp. 375-385. (10.1016/S2215-0366(16)00021-3)
- Lawrie, S. M., O'Donovan, M. C., Saks, E., Burns, T. and Lieberman, J. A. 2016. Improving classification of psychoses. The Lancet Psychiatry 3(4), pp. 367-374. (10.1016/S2215-0366(15)00577-5)
- Carroll, L. S. et al. 2016. Mutation screening of SCN2A in schizophrenia and identification of a novel loss-of-function mutation. Psychiatric Genetics 26(2), pp. 60-65. (10.1097/YPG.0000000000000110)
- Franke, B. et al. 2016. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience 19(3), pp. 420-431. (10.1038/nn.4228)
- Singh, T. et al. 2016. Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders. Nature Neuroscience 19, pp. 571-577. (10.1101/036384)
- Jones, H. J. et al. 2016. Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population. JAMA Psychiatry 73(3), pp. 221-228. (10.1001/jamapsychiatry.2015.3058)
- Richards, A. et al. 2016. Exome arrays capture polygenic rare variant contributions to schizophrenia. Human Molecular Genetics 25(5), pp. 1001-1007. (10.1093/hmg/ddv620)
- Bigdeli, T. B. et al. 2016. Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(2), pp. 276-289. (10.1002/ajmg.b.32402)
- Holland, D. et al. 2016. Estimating effect sizes and expected replication probabilities from GWAS summary statistics. Frontiers in Genetics 7, article number: 15. (10.3389/fgene.2016.00015)
- Lancaster, T. et al. 2016. Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals. Human Brain Mapping 37(2), pp. 491-500. (10.1002/hbm.23044)
- Hannon, E. et al. 2016. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nature Neuroscience 19(1), pp. 48-54. (10.1038/nn.4182)
- Jun, G. et al. 2016. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry 21, pp. 108-117. (10.1038/mp.2015.23)
- Wang, Y. et al. 2016. Leveraging genomic annotations and pleiotropic enrichment for improved replication rates in schizophrenia GWAS. PLoS Genetics 12(1), article number: e1005803. (10.1371/journal.pgen.1005803)
- Hubbard, L. et al. 2016. Evidence of common genetic overlap between schizophrenia and cognition. Schizophrenia Bulletin 42(3), pp. 832-842. (10.1093/schbul/sbv168)
- Pers, T. H., Timshel, P., Ripke, S., Sullivan, P. F., O'Donovan, M. C., Franke, L. and Hirschhorn, J. N. 2016. Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes. Human Molecular Genetics 25(6), pp. 1247-1254. (10.1093/hmg/ddw007)
- Corvin, A. and O'Donovan, M. C. 2016. Psychiatric genetics: what's new in 2015?. The Lancet Psychiatry 3(1), pp. 10-12. (10.1016/S2215-0366(15)00571-4)
- O'Donovan, M. C. and Owen, M. J. 2016. The implications of the shared genetics of psychiatric disorders. Nature Medicine 22, pp. 1214-1219. (10.1038/nm.4196)
2015
- Loh, P. et al. 2015. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nature Genetics 47, pp. 1385-1392. (10.1038/ng.3431)
- Tansey, K. E. et al. 2015. Common alleles contribute to schizophrenia in CNV carriers [Erratum]. Molecular Psychiatry 21, article number: 1153. (10.1038/mp.2015.170)
- Escott-Price, V., Kirov, G., Rees, E., Isles, A. R., Owen, M. J. and O'Donovan, M. C. 2015. No evidence for enrichment in schizophrenia for common allelic associations at imprinted loci. PLoS ONE 10(12), pp. -., article number: e0144172. (10.1371/journal.pone.0144172)
- Andreassen, O. A. et al. 2015. Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLoS Genetics 11(11), article number: e1005544. (10.1371/journal.pgen.1005544)
- Ingason, A. et al. 2015. Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case?control sample of schizophrenia. Translational Psychiatry 5(10), article number: e656. (10.1038/tp.2015.151)
- Walter, K. et al. 2015. The UK10K project identifies rare variants in health and disease. Nature 526, pp. 82-90. (10.1038/nature14962)
- Lee, S. H. et al. 2015. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology 44(5), pp. 1706-1721. (10.1093/ije/dyv136)
- O'Donovan, M. C. 2015. What have we learned from the Psychiatric Genomics Consortium. World Psychiatry 14(3), pp. 291-293. (10.1002/wps.20270)
- Vilhjálmsson, B. et al. 2015. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. American Journal of Human Genetics 97(4), pp. 576-592. (10.1016/j.ajhg.2015.09.001)
- Huang, J. et al. 2015. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nature Communications 6, article number: 8111. (10.1038/ncomms9111)
- O'Donovan, M. C. 2015. Novel genetic advances in schizophrenia: an interview with Michael O'Donovan. BMC Medicine 13, article number: 181. (10.1186/s12916-015-0417-1)
- Jones, L. et al. 2015. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's and Dementia 11(6), pp. 658-671. (10.1016/j.jalz.2014.05.1757)
- Østergaard, S. D. et al. 2015. Associations between potentially modifiable risk factors and Alzheimer disease: A mendelian randomization study. PLOS MEDICINE 12(6), pp. e1001841., article number: e1001841. (10.1371/journal.pmed.1001841)
- Desikan, R. S. et al. 2015. Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer Disease. Circulation 131(23), pp. 2061-2069. (10.1161/CIRCULATIONAHA.115.015489)
- Schmidts, M. et al. 2015. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications 6, article number: 7074. (10.1038/ncomms8074)
- Pocklington, A. et al. 2015. Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia. Neuron 86(5), pp. 1203-1214. (10.1016/j.neuron.2015.04.022)
- Arloth, J. et al. 2015. Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders. Neuron 86(5), pp. 1189-1202. (10.1016/j.neuron.2015.05.034)
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 56(6), pp. 648-656. (10.1111/jcpp.12336)
- Hosp, F. et al. 2015. Quantitative interaction proteomics of neurodegenerative disease proteins. Cell Reports 11(7), pp. 1134-46. (10.1016/j.celrep.2015.04.030)
- Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
- Rees, E., O'Donovan, M. C. and Owen, M. J. 2015. Genetics of schizophrenia. Current Opinion in Behavioral Sciences 2, pp. 8-14. (10.1016/j.cobeha.2014.07.001)
- Spiers, H. et al. 2015. Methylomic trajectories across human fetal brain development. Genome Research 25(3), pp. 338-352. (10.1101/gr.180273.114)
- Bulik-Sullivan, B. K. et al. 2015. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nature Genetics 47(3), pp. 291-295. (10.1038/ng.3211)
- Oertel-Knöchel, V. et al. 2015. Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts. NeuroImage: Clinical 7, pp. 764-770. (10.1016/j.nicl.2015.03.005)
- Vivian-Griffiths, T. et al. 2015. Utilising machine-learning algorithms to uncover complex genetic interactions in schizophrenia [Conference Abstract]. Human Heredity 79(1), pp. 48-48., article number: A46. (10.1159/000381109)
- Farrell, M. S. et al. 2015. Evaluating historical candidate genes for schizophrenia. Molecular Psychiatry 20(5), pp. 555-562. (10.1038/mp.2015.16)
- Taylor, P. N. et al. 2015. Whole-genome sequence-based analysis of thyroid function. Nature Communications 6, article number: 5681. (10.1038/ncomms6681)
- O'Dushlaine, C. et al. 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 18(2), pp. 199-209. (10.1038/nn.3922)
- Desikan, R. S. et al. 2015. Genetic overlap between Alzheimer's Disease and Parkinson's Disease at the MAPT locus. Molecular Psychiatry 20(12), pp. 1588-1595. (10.1038/mp.2015.6)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
- Maier, R. et al. 2015. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. American Journal of Human Genetics 96(2), pp. 283-294. (10.1016/j.ajhg.2014.12.006)
- Kavanagh, D., Tansey, K., O'Donovan, M. C. and Owen, M. J. 2015. Schizophrenia genetics: emerging themes for a complex disorder. Molecular Psychiatry 20(1), pp. 72-76. (10.1038/mp.2014.148)
- Green, E. K. et al. 2015. Copy number variation in bipolar disorder. Molecular Psychiatry 21(1), pp. 89-93. (10.1038/mp.2014.174)
- Hall, J., Trent, S., Thomas, K. L., O'Donovan, M. C. and Owen, M. J. 2015. Genetic risk for schizophrenia: convergence on synaptic pathways Involved in plasticity. Biological Psychiatry 77(1), pp. 52-68. (10.1016/j.biopsych.2014.07.011)
- Tansey, K. E., Owen, M. J. and O'Donovan, M. C. 2015. Schizophrenia genetics: Building the foundations of the future. Schizophrenia Bulletin 41(1), pp. 15-19. (10.1093/schbul/sbu162)
- Rees, E. et al. 2015. Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia. Translational Psychiatry 5(7), article number: e607. (10.1038/tp.2015.99)
2014
- Georgieva, L. et al. 2014. De novo CNVs in bipolar affective disorder and schizophrenia. Human Molecular Genetics 23(24), pp. 6677-6683. (10.1093/hmg/ddu379)
- Kendler, K. S. and O'Donovan, M. C. 2014. A breakthrough in schizophrenia genetics. JAMA Psychiatry 71(12), pp. 1319-1320. (10.1001/jamapsychiatry.2014.1776)
- De Rubeis, S. et al. 2014. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515, pp. 209-215. (10.1038/nature13772)
- Gusev, A. et al. 2014. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. American Journal of Human Genetics 95(5), pp. 535-552. (10.1016/j.ajhg.2014.10.004)
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2014. Genetic risk for Attention Deficit/Hyperactivity Disorder contributes to neurodevelopmental traits in the general population. Biological Psychiatry 76(8), pp. 664-671. (10.1016/j.biopsych.2014.02.013)
- Ruderfer, D. M. et al. 2014. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Molecular Psychiatry 19(9), pp. 1017-1024. (10.1038/mp.2013.138)
- Timpson, N. J. et al. 2014. A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nature Communications 5, article number: 4871. (10.1038/ncomms5871)
- Robinson, E. B. et al. 2014. Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'. Molecular Psychiatry 19(8), pp. 860-1. (10.1038/mp.2013.125)
- Crawford, A. A. et al. 2014. Adverse effects from antidepressant treatment: randomised controlled trial of 601 depressed individuals. Psychopharmacology 231(15), pp. 2921-2931. (10.1007/s00213-014-3467-8)
- Tansey, K. et al. 2014. Copy number variants and therapeutic response to antidepressant medication in major depressive disorder. The Pharmacogenomics Journal 14(4), pp. 395-399. (10.1038/tpj.2013.51)
- Szatkiewicz, J. P. et al. 2014. Copy number variation in schizophrenia in Sweden. Molecular Psychiatry 19(7), pp. 762-773. (10.1038/mp.2014.40)
- Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53(7), pp. 761-770.e26. (10.1016/j.jaac.2014.03.004)
- Craddock, N. J. et al. 2014. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophrenia Bulletin 40(4), pp. 729-736. (10.1093/schbul/sbu069)
- Morris, D. W. et al. 2014. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Human Molecular Genetics 23(12), pp. 3316-3326. (10.1093/hmg/ddu025)
- Escott-Price, V. et al. 2014. Gene-wide analysis detects two new susceptibility genes for Alzheimer's Disease. PLoS ONE 9(6), article number: e94661. (10.1371/journal.pone.0094661)
- Liu, G. et al. 2014. Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies. Neurobiology of Aging 35(4), pp. 786-92. (10.1016/j.neurobiolaging.2013.10.084)
- Pocklington, A., O'Donovan, M. C. and Owen, M. J. 2014. The synapse in schizophrenia. European Journal of Neuroscience 39(7), pp. 1059-1067. (10.1111/ejn.12489)
- Rees, E. et al. 2014. CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. Human Molecular Genetics 23(6), pp. 1669-1676. (10.1093/hmg/ddt540)
- Mulle, J. G. et al. 2014. Reciprocal duplication of the Williams-Beuren Syndrome deletion on chromosome 7q11.23 is associated with schizophrenia. Biological Psychiatry 75(5), pp. 371-7. (10.1016/j.biopsych.2013.05.040)
- Rees, E. et al. 2014. Analysis of copy number variations at 15 schizophrenia-associated loci. British Journal of Psychiatry 204(2), pp. 108-114. (10.1192/bjp.bp.113.131052)
- Fromer, M. et al. 2014. De novo mutations in schizophrenia implicate synaptic networks. Nature 506, pp. 179-184. (10.1038/nature12929)
- Steinberg, S. et al. 2014. Common variant at 16p11.2 conferring risk of psychosis. Molecular Psychiatry 19(1), pp. 108-114. (10.1038/mp.2012.157)
- Andreassen, O. A. et al. 2014. Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Molecular Psychiatry 20(2), pp. 207. (10.1038/mp.2013.195)
- Tansey, K. et al. 2014. Genetic susceptibility for bipolar disorder and response to antidepressants in major depressive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 165(1), pp. 77-83. (10.1002/ajmg.b.32210)
- Martin, J., Hamshere, M. L., O'Donovan, M. C., Rutter, M. and Thapar, A. 2014. Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders 44(1), pp. 204-215. (10.1007/s10803-013-1865-0)
- Hodgson, K. et al. 2014. Genetic predictors of antidepressant side effects: A grouped candidate gene approach in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study. Journal of Psychopharmacology 28(2), pp. 142-150. (10.1177/0269881113517957)
- Bacanu, S. et al. 2014. Functional SNPs are enriched for schizophrenia association signals [Letter]. Molecular Psychiatry 19(3), pp. 276-277. (10.1038/mp.2013.33)
2013
- Green, E. K. et al. 2013. Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. Molecular Psychiatry 18(12), pp. 1302-1307. (10.1038/mp.2012.142)
- van Scheltinga, A. F. T. et al. 2013. Schizophrenia genetic variants are not associated with intelligence. Psychological Medicine 43(12), pp. 2563-2570. (10.1017/S0033291713000196)
- Grozeva, D. et al. 2013. Reduced burden of very large and rare CNVs in bipolar affective disorder. Bipolar Disorders 15(8), pp. 893-8. (10.1111/bdi.12125)
- Lambert, J. et al. 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease [Letter]. Nature Genetics 45(12), pp. 1452-1458. (10.1038/ng.2802)
- Rees, E. et al. 2013. Evidence that duplications of 22q11.2 protect against schizophrenia. Molecular Psychiatry n/a (10.1038/mp.2013.156)
- Zammit, S. et al. 2013. A population-based study of genetic variation and psychotic experiences in adolescents. Schizophrenia Bulletin 40(6), pp. 1254-1262. (10.1093/schbul/sbt146)
- de Candia, T. et al. 2013. Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. American Journal of Human Genetics 93(3), pp. 463-470. (10.1016/j.ajhg.2013.07.007)
- Ruderfer, D. et al. 2013. Mosaic copy number variation in schizophrenia. European Journal of Human Genetics 21(9), pp. 1007-1011. (10.1038/ejhg.2012.287)
- Lee, S. et al. 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45(9), pp. 984-994. (10.1038/ng.2711)
- Ripke, S. et al. 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics 45(10), pp. 1150-1159. (10.1038/ng.2742)
- Walters, J. T. R. et al. 2013. The role of the major histocompatibility complex region in cognition and brain structure: a schizophrenia GWAS follow-up. American Journal of Psychiatry 170(8), pp. 877-885. (10.1176/appi.ajp.2013.12020226)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
- Majounie, E. et al. 2013. Variation in tau isoform expression in different brain regions and disease states. Neurobiology of Aging 34(7), pp. 1922.e7-1922.e12. (10.1016/j.neurobiolaging.2013.01.017)
- Yang, L. et al. 2013. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162(5), pp. 419-430. (10.1002/ajmg.b.32169)
- Hamshere, M. L. et al. 2013. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Molecular Psychiatry 18(6), pp. 708-712. (10.1038/mp.2012.67)
- Landerl, K. et al. 2013. Predictors of developmental dyslexia in European orthographies with varying complexity. Journal of Child Psychology and Psychiatry 54(6), pp. 686-694. (10.1111/jcpp.12029)
- Zou, F. et al. 2013. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's Disease pathology. PLoS ONE 8(5), article number: e64802. (10.1371/journal.pone.0064802)
- Kavanagh, D., Dwyer, S., O'Donovan, M. C. and Owen, M. J. 2013. The ENCODE project: implications for psychiatric genetics. Molecular Psychiatry 18(5), pp. 540-542. (10.1038/mp.2013.13)
- Smoller, J. W. et al. 2013. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet 381(9875), pp. 1371-1379. (10.1016/S0140-6736(12)62129-1)
- Lambert, J. C. et al. 2013. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease [Correction]. Molecular Psychiatry 18(4), pp. 521. (10.1038/mp.2012.75)
- Kronenberg, F. et al. 2013. Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease [Article]. PLoS ONE 8(4), pp. e59905. (10.1371/journal.pone.0059905)
- Ripke, S. et al. 2013. A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry 18(4), pp. 497-511. (10.1038/mp.2012.21)
- Gibson, G. et al. 2013. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genetics 9(4), article number: e1003449. (10.1371/journal.pgen.1003449)
- Terwisscha van Scheltinga, A. F. et al. 2013. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry 73(6), pp. 525-531. (10.1016/j.biopsych.2012.08.017)
- Guha, S. et al. 2013. Implication of a rare deletion at distal 16p11.2 in schizophrenia. JAMA Psychiatry 70(3), pp. 253-260. (10.1001/2013.jamapsychiatry.71)
- Williams, H. J., Monks, S., Murphy, K. C., Kirov, G., O'Donovan, M. C. and Owen, M. J. 2013. Schizophrenia two-hit hypothesis in velo-cardio facial syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162(2), pp. 177-182. (10.1002/ajmg.b.32129)
- Donohoe, G. et al. 2013. Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253. Genes, Brain and Behavior 12(2), pp. 203-209. (10.1111/gbb.12016)
- Chapman, J. et al. 2013. A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk. Human Molecular Genetics 22(4), pp. 816-824. (10.1093/hmg/dds476)
- Andreassen, O. et al. 2013. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. American Journal of Human Genetics 92(2), pp. 197-209. (10.1016/j.ajhg.2013.01.001)
- Kim, Y. et al. 2013. Non-random mating, parent-of-origin, and maternal-fetal incompatibility effects in schizophrenia. Schizophrenia Research 143(1), pp. 11-17. (10.1016/j.schres.2012.11.002)
- Visscher, P. M. et al. 2013. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genetics 9(4), pp. e1003455. (10.1371/journal.pgen.1003455)
- Chapuis, J. et al. 2013. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology [Article]. Molecular Psychiatry 18(11), pp. 1225-1234. (10.1038/mp.2013.1)
- Green, E. K. et al. 2013. Association at SYNE1 in both bipolar disorder and recurrent major depression. Molecular Psychiatry 18, pp. 614-617. (10.1038/mp.2012.48)
- Prata, D. P. et al. 2013. Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity. Human Brain Mapping 34(9), pp. 2025-2031. (10.1002/hbm.22045)
- Kirov, G. et al. 2013. The penetrance of copy number variations for schizophrenia and developmental delay. Biological Psychiatry 75(5), pp. 378-385. (10.1016/j.biopsych.2013.07.022)
- Aberg, K. A. et al. 2013. A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry 70(6), pp. 573-581. (10.1001/jamapsychiatry.2013.288)
2012
- Hollingworth, P. et al. 2012. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Molecular Psychiatry 17(12), pp. 1316-1327. (10.1038/mp.2011.125)
- Eyre, S. et al. 2012. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics 44(12), pp. 1336-1340. (10.1038/ng.2462)
- Cooper, J. D. et al. 2012. Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics 21(23), pp. 5202-5208. (10.1093/hmg/dds357)
- Jostins, L. et al. 2012. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491(7422), pp. 119-124. (10.1038/nature11582)
- Williams, H. J., Georgieva, L., Dwyer, S. L., Kirov, G., Owen, M. J. and O'Donovan, M. C. 2012. Absence of de novo point mutations in exons of GRIN2B in a large schizophrenia trio sample [Letter]. Schizophrenia Research 141(2-3), pp. 274-276. (10.1016/j.schres.2012.08.024)
- O'Donovan, M. C., Owen, M. J., Walters, J. T. R., Irish Schizophrenia Genomics Consortium, . and Wellcome Trust Case Control Consortium 2, . 2012. Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biological psychiatry 72(8), pp. 620-628. (10.1016/j.biopsych.2012.05.035)
- Fromer, M. et al. 2012. Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth. American Journal of Human Genetics 91(4), pp. 597-607. (10.1016/j.ajhg.2012.08.005)
- Tansey, K. E. et al. 2012. Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. Plos Medicine 9(10), article number: e1001326. (10.1371/journal.pmed.1001326)
- Levinson, D. F. et al. 2012. Genome-wide association study of multiplex schizophrenia pedigrees. American Journal of Psychiatry 169(9), pp. 963-973. (10.1176/appi.ajp.2012.11091423)
- Hamilton, G. et al. 2012. The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B(6), pp. 696-709. (10.1002/ajmg.b.32073)
- Ayalew, M. et al. 2012. Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Molecular Psychiatry 17(9), pp. 887-905. (10.1038/mp.2012.37)
- Shi, H. et al. 2012. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging 33(8), article number: 1849.e5. (10.1016/j.neurobiolaging.2012.02.014)
- Hamilton, G. et al. 2012. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiology of Aging 33(8), article number: 1848.e1. (10.1016/j.neurobiolaging.2012.02.005)
- Escott-Price, V., Schmidt, K. M., Vedernikov, A., Owen, M. J., Craddock, N. J., Holmans, P. A. and O'Donovan, M. C. 2012. Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis. European Journal of Human Genetics 20(8), pp. 890-896. (10.1038/ejhg.2012.8)
- Sullivan, P. F., Daly, M. J. and O'Donovan, M. C. 2012. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nature Reviews Genetics 13(8), pp. 537-551. (10.1038/nrg3240)
- Jia, P. et al. 2012. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Computational Biology 8(7), article number: e1002587. (10.1371/journal.pcbi.1002587)
- Derks, E. M. et al. 2012. Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis. PLoS ONE 7(6), article number: e37852. (10.1371/journal.pone.0037852)
- Rees, E., Kirov, G., O'Donovan, M. C. and Owen, M. J. 2012. De Novo mutation in schizophrenia. Schizophrenia Bulletin 38(3), pp. 377-381. (10.1093/schbul/sbs047)
- Hudson, G. et al. 2012. No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology 78(14), pp. 1038-1042. (10.1212/WNL.0b013e31824e8f1d)
- Keller, M. C. et al. 2012. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. Plos Genetics 8(4), article number: e1002656. (10.1371/journal.pgen.1002656)
- Håvik, B. et al. 2012. DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. PLoS ONE 7(4), pp. e35424. (10.1371/journal.pone.0035424)
- Grozeva, D. et al. 2012. Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia. Schizophrenia Research 135(1-3), pp. 1-7. (10.1016/j.schres.2011.11.004)
- Lambert, J. C. et al. 2012. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. Molecular Psychiatry 18, pp. 461-470. (10.1038/mp.2012.14)
- Collins, A. L., Kim, Y., Sklar, P., O'Donovan, M. C. and Sullivan, P. F. 2012. Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. Psychological Medicine 42(3), pp. 607-616. (10.1017/S0033291711001607)
- Kirov, G. et al. 2012. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Molecular Psychiatry 17(2), pp. 142-153. (10.1038/mp.2011.154)
- Jia, P. et al. 2012. A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. Journal of Medical Genetics 49(2), pp. 96-103. (10.1136/jmedgenet-2011-100397)
- Richards, A. et al. 2012. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Molecular Psychiatry 17(2), pp. 193-201. (10.1038/mp.2011.11)
- Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
- Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169(2), pp. 195-204. (10.1176/appi.ajp.2011.11060822)
- Gerrish, A. et al. 2012. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's Disease. Journal of Alzheimer's Disease 28(2), pp. 377-387. (10.3233/JAD-2011-110824)
- Sullivan, P., Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2012. Don't give up on GWAS [Letter]. Molecular Psychiatry 17(1), pp. 2-3. (10.1038/mp.2011.94)
- Chapman, R. M., Tinsley, C. L., Doyle, A. M., O'Donovan, M. C. and Blake, D. J. 2012. Inducible over-expression and siRNA mediated knock-down of the schizophrenia susceptibility gene ZNF804A: Detection of altered gene expression and splicing using whole genome exon arrays. International Journal of Developmental Neuroscience 30(8), pp. 673-673. (10.1016/j.ijdevneu.2012.10.011)
- Doherty, J. L., O'Donovan, M. C. and Owen, M. J. 2012. Recent genomic advances in schizophrenia. Clinical Genetics 81(2), pp. 103-109. (10.1111/j.1399-0004.2011.01773.x)
2011
- Hinney, A. et al. 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 888-897. (10.1002/ajmg.b.31246)
- Cardno, A. G. et al. 2011. A genomewide linkage study of age at onset in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(8), pp. 929-940. (10.1002/ajmg.1404)
- Rees, E., Escott-Price, V., Owen, M. J., O'Donovan, M. C. and Kirov, G. 2011. De novo rates and selection of schizophrenia-associated copy number variants. Biological Psychiatry 70(12), pp. 1109-1114. (10.1016/j.biopsych.2011.07.011)
- Tognin, S., Viding, E., McCrory, E. J., Taylor, L., O'Donovan, M. C., McGuire, P. and Mechelli, A. 2011. Effects of DTNBP1 genotype on brain development in children. Journal of Child Psychology and Psychiatry 52(12), pp. 1287-1294. (10.1111/j.1469-7610.2011.02427.x)
- Sklar, P. et al. 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 [Letter]. Nature Genetics 43(10), pp. 977-983. (10.1038/ng.943)
- Ripke, S. et al. 2011. Genome-wide association study identifies five new schizophrenia loci [Letter]. Nature Genetics 43(10), pp. 969-976. (10.1038/ng.940)
- Chen, J. et al. 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131(1-3), pp. 43-51.
- Escott-Price, V. et al. 2011. An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction. Biological Psychiatry 70(2), pp. 198-203. (10.1016/j.biopsych.2011.01.034)
- Chen, J. et al. 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131(1-3), pp. 43-51. (10.1016/j.schres.2011.06.023)
- Lewis, G. et al. 2011. Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial. British Journal of Psychiatry 198(6), pp. 464-471. (10.1192/bjp.bp.110.082727)
- Hollingworth, P. et al. 2011. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics 43(5), pp. 429-435. (10.1038/ng.803)
- Williams, H. J. et al. 2011. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Molecular Psychiatry 16(4), pp. 429-441. (10.1038/mp.2010.36)
- Stergiakouli, E. et al. 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10(3), pp. 334-344. (10.1111/j.1601-183x.2010.00672.x)
- Ingason, A. et al. 2011. Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness. American Journal of Psychiatry 168(4), pp. 408-417. (10.1176/appi.ajp.2010.09111660)
- Ikeda, M. et al. 2011. Genome-Wide Association Study of Schizophrenia in a Japanese Population. Biological Psychiatry 69(5), pp. 472-478. (10.1016/j.biopsych.2010.07.010)
- O'Dushlaine, C. et al. 2011. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Molecular Psychiatry 16(3), pp. 286-292. (10.1038/mp.2010.7)
- Zuliani, R. et al. 2011. Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry Research: Neuroimaging 191(2), pp. 133-137. (10.1016/j.pscychresns.2010.11.001)
- Reilly, M. P. et al. 2011. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. The Lancet 377(9763), pp. 383-392. (10.1016/S0140-6736(10)61996-4)
- Williams, H. J. et al. 2011. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Human Molecular Genetics 20(2), pp. 387-391. (10.1093/hmg/ddq471)
- Bridges, M. et al. 2011. Genetic classification of populations using supervised learning. PLoS ONE 6(5), article number: e14802. (10.1371/journal.pone.0014802)
- Hamshere, M. L. et al. 2011. Polygenic dissection of the bipolar phenotype. British Journal of Psychiatry 198(4), pp. 284-288. (10.1192/bjp.bp.110.087866)
- Williams, N. M., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2011. Structural variations in attention-deficit hyperactivity disorder - Authors' reply [Letter]. The Lancet 377(9763), pp. 378. (10.1016/S0140-6736(11)60121-9)
- Green, E. K. et al. 2011. DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(4), pp. 490-492. (10.1002/ajmg.b.31187)
- Smith, R. L. et al. 2011. Analysis of neurogranin (NRGN) in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(5), pp. 532-535. (10.1002/ajmg.b.31191)
- Sims, R. et al. 2011. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(7), pp. 764-771. (10.1002/ajmg.b.31216)
- Williams, H. J., Escott-Price, V., Smith, R. L., Dwyer, S. L., Russo, G., Owen, M. J. and O'Donovan, M. C. 2011. Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(7), pp. 781-784. (10.1002/ajmg.b.31219)
- Carroll, L. S., Williams, H. J., Walters, J. T. R., Kirov, G., O'Donovan, M. C. and Owen, M. J. 2011. Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(7), pp. 844-849. (10.1002/ajmg.b.31231)
- Hamshere, M. L. et al. 2011. Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 929-940. (10.1002/ajmg.b.31240)
- Escott-Price, V., O'Dushlaine, C., Purcell, S., Craddock, N. J., Holmans, P. A. and O'Donovan, M. C. 2011. Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study. Genetic Epidemiology 35(8), pp. 861-866. (10.1002/gepi.20636)
- Cichon, S. et al. 2011. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. American Journal of Human Genetics 88(3), pp. 372-381. (10.1016/j.ajhg.2011.01.017)
- Hansen, T. et al. 2011. At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia. Biological Psychiatry 70(1), pp. 59-63. (10.1016/j.biopsych.2011.01.031)
- Donohoe, G. et al. 2011. A neuropsychological investigation of the genome wide associated schizophrenia risk variant NRGN rs12807809 [Letter]. Schizophrenia Research 125(2-3), pp. 304-306. (10.1016/j.schres.2010.10.019)
- Steinberg, S. et al. 2011. Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Human Molecular Genetics 20(20), pp. 4076-4081. (10.1093/hmg/ddr325)
- Yosifova, A. et al. 2011. Genome-wide association study on bipolar disorder in the Bulgarian population. Genes, Brain and Behavior 10(7), pp. 789-797. (10.1111/j.1601-183X.2011.00721.x)
- Owen, M. J., O'Donovan, M. C., Thapar, A. and Craddock, N. J. 2011. Neurodevelopmental hypothesis of schizophrenia. British Journal of Psychiatry 198(3), pp. 173-175. (10.1192/bjp.bp.110.084384)
- Wiles, N. J. et al. 2011. Severity of depression and response to antidepressants: GENPOD randomised controlled trial. British Journal of Psychiatry 200(2), pp. 130-136. (10.1192/bjp.bp.110.091223)
- Lips, E. S. et al. 2011. Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Molecular Psychiatry, pp. 1-11. (10.1038/mp.2011.117)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
- Dwyer, S. L. et al. 2011. Investigation of rare non-synonymous variants at ABCA13 in schizophrenia and bipolar disorder [letter]. Molecular Psychiatry 16(8), pp. 790-791. (10.1038/mp.2011.2)
- Ruderfer, D. M. et al. 2011. A family-based study of common polygenic variation and risk of schizophrenia [Letter]. Molecular Psychiatry 16(9), pp. 887-888. (10.1038/mp.2011.34)
- Rietschel, M. et al. 2011. Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe. Molecular Psychiatry, pp. 1-12. (10.1038/mp.2011.80)
2010
- Langley, K., Heron, J., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2010. Genotype link with extreme antisocial behavior: The contribution of cognitive pathways. Archives of General Psychiatry 67(12), pp. 1317-1323. (10.1001/archgenpsychiatry.2010.163)
- Carroll, L. S. et al. 2010. Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha. Molecular Psychiatry 15(11), pp. 1101-1111. (10.1038/mp.2009.96)
- Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype [Corrigendum]. Molecular Psychiatry 15(11), pp. 1121-1121. (10.1038/mp.2010.62)
- Jones, L. et al. 2010. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS ONE 5(11), article number: e13950. (10.1371/journal.pone.0013950)
- Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376(9750), pp. 1401-1408. (10.1016/S0140-6736(10)61109-9)
- Green, E. K. et al. 2010. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Molecular Psychiatry 15(10), pp. 1016-1022. (10.1038/mp.2009.49)
- Allison, D. B. et al. 2010. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genetics 6(9), article number: e1001097. (10.1371/journal.pgen.1001097)
- Pagnamenta, A. T. et al. 2010. Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biological psychiatry 68(4), pp. 320-328. (10.1016/j.biopsych.2010.02.002)
- Escott-Price, V. et al. 2010. Genetic differences between five European populations. Human Heredity 70(2), pp. 141-149. (10.1159/000313854)
- Walters, J. T. R. et al. 2010. Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Archives of General Psychiatry 67(7), pp. 692-700. (10.1001/archgenpsychiatry.2010.81)
- Grozeva, D. et al. 2010. Rare copy number variants: A point of rarity in genetic risk for bipolar disorder and schizophrenia. Archives of General Psychiatry 67(4), pp. 318-327. (10.1001/archgenpsychiatry.2010.25)
- Craddock, N. J. et al. 2010. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 464(7289), pp. 713-720. (10.1038/nature08979)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196(3), pp. 235-240. (10.1192/bjp.bp.109.066274)
- Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Molecular Psychiatry 15(2), pp. 146-153. (10.1038/mp.2008.66)
- Ikeda, M. et al. 2010. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biological psychiatry 67(3), pp. 263-269. (10.1016/j.biopsych.2009.08.030)
- Ikeda, M. et al. 2010. Copy number variation in schizophrenia in the Japanese population. Biological Psychiatry 67(3), pp. 283-286. (10.1016/j.biopsych.2009.08.034)
- Mechelli, A. et al. 2010. Dysbindin modulates brain function during visual processing in children. NeuroImage 49(1), pp. 817-822. (10.1016/j.neuroimage.2009.07.030)
- Owen, M. J., Craddock, N. J. and O'Donovan, M. C. 2010. Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia. Archives of General Psychiatry 67(7), pp. 667-673. (10.1001/archgenpsychiatry.2010.69)
- Ikeda, M. et al. 2010. Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(4), pp. 980-982. (10.1002/ajmg.b.31060)
- Green, E. K. et al. 2010. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(7), pp. 1347-1349. (10.1002/ajmg.b.31108)
- Dwyer, S. L., Williams, H., Holmans, P. A., Escott-Price, V., Craddock, N. J., Owen, M. J. and O'Donovan, M. C. 2010. No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(8), pp. 1411-1416. (10.1002/ajmg.b.31117)
- Talkowski, M. E. et al. 2010. Fine-mapping reveals novel alternative splicing of the dopamine transporter. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(8), pp. 1434-1447. (10.1002/ajmg.b.31125)
- Neale, B. M. et al. 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 884-897. (10.1016/j.jaac.2010.06.008)
- Blake, D. J., Forrest, M., Chapman, R. M., Tinsley, C. L., O'Donovan, M. C. and Owen, M. J. 2010. TCF4, Schizophrenia, and Pitt-Hopkins Syndrome. Schizophrenia Bulletin 36(3), pp. 443-447. (10.1093/schbul/sbq035)
- Liu, Y. et al. 2010. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder [Letter]. Molecular Psychiatry 16(1), pp. 2-4. (10.1038/mp.2009.107)
- Breuer, R. et al. 2010. Independent evidence for the selective influence of GABAA receptors on one component of the bipolar disorder phenotype [letter]. Molecular Psychiatry 16(6), pp. 587-589. (10.1038/mp.2010.67)
- Chen, X. et al. 2010. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Molecular Psychiatry 16(11), pp. 1117-1129. (10.1038/mp.2010.96)
2009
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19(6), pp. 312-319. (10.1097/YPG.0b013e3283328df4)
- Hayesmoore, J. B. G., Bray, N. J., Cross, W. C., Owen, M. J., O'Donovan, M. C. and Morris, H. R. 2009. The effect of age and the H1c MAPT haplotype on MAPT expression in human brain. Neurobiology of Aging 30(10), pp. 1652-1656. (10.1016/j.neurobiolaging.2007.12.017)
- Liu, Y. et al. 2009. Whole genome association study in a homogenous population in Shandong Peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia. Journal of Biomedicine and Biotechnology, article number: 536918. (10.1155/2009/536918)
- Harold, D. et al. 2009. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Letter]. Nature Genetics 41(10), pp. 1088-1093. (10.1038/ng.440)
- Donohoe, G. et al. 2009. Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects. Archives of General Psychiatry 66(10), pp. 1045-1054. (10.1001/archgenpsychiatry.2009.139)
- McCarthy, S. E. et al. 2009. Microduplications of 16p11.2 are associated with schizophrenia. Nature Genetics 41(11), pp. 1223-1227. (10.1038/ng.474)
- Ng, M. Y. M. et al. 2009. Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Molecular Psychiatry 14(8), pp. 774-785. (10.1038/mp.2008.135)
- Holmans, P. A. et al. 2009. Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms. Molecular Psychiatry 14(8), pp. 786-795. (10.1038/mp.2009.11)
- Orozco, G. et al. 2009. Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Human Molecular Genetics 18(14), pp. 2693-2699. (10.1093/hmg/ddp193)
- Holmans, P. A. et al. 2009. Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. American Journal of Human Genetics 85(1), pp. 13-24. (10.1016/j.ajhg.2009.05.011)
- O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2009. Genetics of psychosis; insights from views across the genome. Human Genetics 126(1), pp. 3-12. (10.1007/s00439-009-0703-0)
- Raychaudhuri, S. et al. 2009. Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions. Plos Genetics 5(6), pp. -. (10.1371/journal.pgen.1000534)
- Kirov, G. et al. 2009. Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Human Molecular Genetics 18(8), pp. 1497-1503. (10.1093/hmg/ddp043)
- Escott-Price, V. et al. 2009. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Molecular Psychiatry 14(3), pp. 252-260. (10.1038/mp.2008.133)
- O'Donovan, M. C. et al. 2009. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry 14(1), pp. 30-36. (10.1038/mp.2008.108)
- Hamshere, M. L. et al. 2009. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. British Journal of Psychiatry 195(1), pp. 23-29. (10.1192/bjp.bp.108.061424)
- Harold, D. et al. 2009. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Corrigendum]. Nature Genetics 41(10), pp. 1156. (10.1038/ng1009-1156d)
- Purcell, S. M. et al. 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460(7256), pp. 748-752. (10.1038/nature08185)
- Williams, H., Owen, M. J. and O'Donovan, M. C. 2009. Schizophrenia genetics: new insights from new approaches. British Medical Bulletin 91(1), pp. 61-74. (10.1093/bmb/ldp017)
- O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2009. Strong evidence for multiple psychosis susceptibility genes - a rejoinder to Crow [Letter]. Psychological Medicine 39(1), pp. 170-171. (10.1017/S0033291708004583)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
- Morgan, A. R. et al. 2009. Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(1), pp. 61-64. (10.1002/ajmg.b.30768)
- Talkowski, M. E. et al. 2009. Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(4), pp. 560-569. (10.1002/ajmg.b.30862)
- Carroll, L. S., Kendall, K., O'Donovan, M. C., Owen, M. J. and Williams, N. M. 2009. Evidence that putative ADHD low risk alleles atSNAP25may increase the risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(7), pp. 893-899. (10.1002/ajmg.b.30915)
- Green, E. K. et al. 2009. P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(8), pp. 1063-1069. (10.1002/ajmg.b.30931)
- Abraham, R. A., Sims, R., Carroll, L. S., Hollingworth, P., O'Donovan, M. C., Williams, J. and Owen, M. J. 2009. An association study of common variation at theMAPTlocus with late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(8), pp. 1152-1155. (10.1002/ajmg.b.30951)
- Dwyer, S. L., Carroll, L. S., Mantripragada, K. K., Owen, M. J., O'Donovan, M. C. and Williams, N. M. 2009. Mutation screening of the DTNBP1 exonic sequence in 669 schizophrenics and 710 controls using high-resolution melting analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(3), pp. 766-774. (10.1002/ajmg.b.31045)
- O'Donovan, M. C. and Owen, M. J. 2009. Genetics and the brain: many pathways to enlightenment [Editorial]. Human Genetics 126(1), pp. 1-2. (10.1007/s00439-009-0705-y)
- Owen, M. J., Williams, H. J. and O'Donovan, M. C. 2009. Schizophrenia genetics: advancing on two fronts. Current Opinion in Genetics & Development 19(3), pp. 266-270. (10.1016/j.gde.2009.02.008)
- Gerrish, A., Williams, H. J., Escott-Price, V., Owen, M. J., O'Donovan, M. C. and Williams, N. M. 2009. An examination of MUTED as a schizophrenia susceptibility gene [Letter]. Schizophrenia Research 107(1), pp. 110-111. (10.1016/j.schres.2008.08.011)
- Sims, R. et al. 2009. Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease. Neuroscience Letters 461(1), pp. 54-59. (10.1016/j.neulet.2009.05.051)
- Yosifova, A. et al. 2009. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. Journal of Affective Disorders 117(1-2), pp. 87-97. (10.1016/j.jad.2008.12.021)
- Ingason, A. et al. 2009. A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Human Molecular Genetics 19(7), pp. 1379-1386. (10.1093/hmg/ddq009)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2009. Psychosis genetics: modeling the relationship between Schizophrenia, Bipolar Disorder, and Mixed (or "Schizoaffective") Psychoses. Schizophrenia Bulletin 35(3), pp. 482-490. (10.1093/schbul/sbp020)
- Kirov, G., Rujescu, D., Ingason, A., Collier, D. A., O'Donovan, M. C. and Owen, M. J. 2009. Neurexin 1 (NRXN1) deletions in Schizophrenia. Schizophrenia Bulletin 35(5), pp. 851-854. (10.1093/schbul/sbp079)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
- Williams, H. J., Owen, M. J. and O'Donovan, M. C. 2009. New findings from genetic association studies of schizophrenia. Journal of Human Genetics 54(1), pp. 9-14. (10.1038/jhg.2008.7)
- Betcheva, E. T. et al. 2009. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. Journal of Human Genetics 54(2), pp. 98-107. (10.1038/jhg.2008.14)
2008
- Barton, A. et al. 2008. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics 40(10), pp. 1156-1159. (10.1038/ng.218)
- Hayesmoore, J. B., Bray, N. J., Owen, M. J. and O'Donovan, M. C. 2008. DISC1mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(7), pp. 1065-1069. (10.1002/ajmg.b.30715)
- Ikeda, M. et al. 2008. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics 9(10), pp. 1437-1443. (10.2217/14622416.9.10.1437)
- Craddock, N. J. et al. 2008. Wake up call: Response from authors [eLetter]. British Journal of Psychiatry
- Abraham, R. et al. 2008. A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Medical Genomics 1(1), article number: 44. (10.1186/1755-8794-1-44)
- Ferreira, M. A. R. et al. 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 40(9), pp. 1056-1058. (10.1038/ng.209)
- Georgieva, L. et al. 2008. Support for Neuregulin 1 as a susceptibility gene for Bipolar disorder and schizophrenia. Biological psychiatry 64(5), pp. 419-427. (10.1016/j.biopsych.2008.03.025)
- Barton, A. et al. 2008. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Human Molecular Genetics 17(15), pp. 2274-2279. (10.1093/hmg/ddn128)
- Loos, R. J. F. et al. 2008. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 40(6), pp. 768-775. (10.1038/ng.140)
- Fisher, S. A. et al. 2008. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics 40(6), pp. 710-712. (10.1038/ng.145)
- Thomas, L. et al. 2008. GENetic and clinical predictors of treatment response in depression: the GenPod randomised trial protocol. Trials 9(1), pp. 29-29. (10.1186/1745-6215-9-29)
- Zaharieva, I., Georgieva, L., Nikolov, I., Kirov, G., Owen, M. J., O'Donovan, M. C. and Toncheva, D. 2008. Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping. BMC Psychiatry 8(1), pp. 11-11. (10.1186/1471-244X-8-11)
- Williams, N. M. et al. 2008. Strong evidence that GNB1L is associated with schizophrenia. Human Molecular Genetics 17(4), pp. 555-566. (10.1093/hmg/ddm330)
- Kirov, G. et al. 2008. Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Human Molecular Genetics 17(3), pp. 458-465. (10.1093/hmg/ddm323)
- Buxbaum, J. D. et al. 2008. Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Molecular psychiatry 13, pp. 162-172. (10.1038/sj.mp.4001991)
- Williams, N. M. et al. 2008. Analysis of copy number variation using quantitative interspecies competitive PCR. Nucleic Acids Research 36(17), pp. e112-e112. (10.1093/nar/gkn495)
- Kirov, G. et al. 2008. A genome-wide association study in 574 schizophrenia trios using DNA pooling. Molecular Psychiatry 14(8), pp. 796-803. (10.1038/mp.2008.33)
- Stone, J. L. et al. 2008. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455(7210), pp. 237-241. (10.1038/nature07239)
- Caspi, A. et al. 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 65(2), pp. 203-210. (10.1001/archgenpsychiatry.2007.24)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
- Li, Y. et al. 2008. SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiology of Disease 29(2), pp. 293-296. (10.1016/j.nbd.2007.09.001)
- Li, Y. et al. 2008. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human Molecular Genetics 17(5), pp. 759-767. (10.1093/hmg/ddm348)
- Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17(8), pp. 1169-1174. (10.1093/hmg/ddn006)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2008. Genome-wide association studies in psychiatry: lessons from early studies of non-psychiatric and psychiatric phenotypes [Guest Editorial]. Molecular Psychiatry 13(7), pp. 649-653. (10.1038/mp.2008.45)
- Craddock, N. J. et al. 2008. Authors' reply. The British Journal of Psychiatry 193(6), pp. 517. (10.1192/bjp.193.6.517)
- Shifman, S. et al. 2008. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLOS Genetics 4(2), article number: e28. (10.1371/journal.pgen.0040028)
- Craddock, N. J. et al. 2008. Wake-up call for British psychiatry. British Journal of Psychiatry 193(1), pp. 6-9. (10.1192/bjp.bp.108.053561)
- Fekadu, A. et al. 2008. Validity of the concept of minor depression in a developing country setting. Journal of Nervous and Mental Disease 196(1), pp. 22-28. (10.1097/NMD.0b013e31815fa4d4)
- O'Donovan, M. C. et al. 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics 40(9), pp. 1053-1055. (10.1038/ng.201)
- O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2008. Schizophrenia: complex genetics, not fairy tales. Psychological Medicine 38(12), pp. 1697-1699. (10.1017/S0033291708003802)
- O'Donovan, M. C., Kirov, G. and Owen, M. J. 2008. Phenotypic variations on the theme of CNVs. Nature Genetics 40(12), pp. 1392-1393. (10.1038/ng1208-1392)
- Richards, A. L., Holmans, P. A., O'Donovan, M. C., Owen, M. J. and Jones, L. 2008. A comparison of four clustering methods for brain expression microarray data. BMC Bioinformatics 9, article number: 490. (10.1186/1471-2105-9-490)
2007
- Nejentsev, S. et al. 2007. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450(7171), pp. 887-892. (10.1038/nature06406)
- Thomson, W. et al. 2007. Rheumatoid arthritis association at 6q23. Nature Genetics 39(12), pp. 1431-1433. (10.1038/ng.2007.32)
- Williams, H. et al. 2007. Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia. Schizophrenia Research 97(1-3), pp. 271-276. (10.1016/j.schres.2007.09.004)
- Thapar, A., Langley, K., Owen, M. J. and O'Donovan, M. C. 2007. Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine 37(12), pp. 1681-1692. (10.1017/S0033291707000773)
- Zammit, S., Spurlock, G., Williams, H., Norton, N., Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2007. Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. British Journal of Psychiatry 191(5), pp. 402-407. (10.1192/bjp.bp.107.036129)
- Hollingworth, P. et al. 2007. Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(7), pp. 841-848. (10.1002/ajmg.b.30515)
- Morgan, A. et al. 2007. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(6), pp. 762-770. (10.1002/ajmg.b.30509)
- Thapar, A., Harold, G. T., Rice, F., Langley, K. and O'Donovan, M. C. 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19(4), pp. 989-1004. (10.1017/S0954579407000491)
- Hamshere, M. L. et al. 2007. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics Advanc, pp. 1-34. (10.1093/hmg/ddm224)
- Domschke, K., Deckert, J., O'Donovan, M. C. and Glatt, S. J. 2007. Meta-analysis of COMT val158met in panic disorder: Ethnic heterogeneity and gender specificity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(5), pp. 667-673. (10.1002/ajmg.b.30494)
- Norton, N. et al. 2007. Association analysis of AKT1 and schizophrenia in a UK case control sample. Schizophrenia Research 93(1-3), pp. 58-65. (10.1016/j.schres.2007.02.006)
- Burton, P. R. et al. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145), pp. 661-678. (10.1038/nature05911)
- Harold, D. et al. 2007. Interaction between theADAM12 andSH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(4), pp. 448-452. (10.1002/ajmg.b.30456)
- Hamilton, G. et al. 2007. Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(4), pp. 508-516. (10.1002/ajmg.b.30503)
- Williams, H., Owen, M. J. and O'Donovan, M. C. 2007. Is COMT a susceptibility gene for schizophrenia?. Schizophrenia Bulletin 33(3), pp. 635-641. (10.1093/schbul/sbm019)
- Escott-Price, V. and O'Donovan, M. C. 2007. Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation. Human Heredity 64(1), pp. 63-73. (10.1159/000101424)
- O'Donovan, M. C. et al. 2007. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia [Conference Abstract]. Schizophrenia bulletin 33(2), pp. 311-312. (10.1093/schbul/sbm004)
- Grupe, A. et al. 2007. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics 16(8), pp. 865-873. (10.1093/hmg/ddm031)
- Gunnell, D. et al. 2007. IGF1, growth pathway polymorphisms and schizophrenia: A pooling study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(1), pp. 117-120. (10.1002/ajmg.b.30396)
- Hamilton, G., Proitsi, P., Williams, J., O'Donovan, M. C., Owen, M. J., Powell, J. and Lovestone, S. 2007. Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease. Neuromolecular Medicine 9(4), pp. 331-334. (10.1007/s12017-007-8013-y)
- Morgan, A. et al. 2007. Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(6), pp. 727-731. (10.1002/ajmg.b.30670)
- Talkowski, M. E. et al. 2007. A network of dopaminergic gene variations implicated as risk factors for schizophrenia. Human Molecular Genetics 17(5), pp. 747-758. (10.1093/hmg/ddm347)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
- Burton, P. R. et al. 2007. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics 39(11), pp. 1329-1337. (10.1038/ng.2007.17)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2007. Symptom dimensions and the Kraepelinian dichotomy. British Journal of Psychiatry 190(4), pp. 361. (10.1192/bjp.190.4.361)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2007. Phenotypic and genetic complexity of psychosis Invited commentary on .. Schizophrenia: a common disease caused by multiple rare alleles. British Journal of Psychiatry 190(3), pp. 200-203. (10.1192/bjp.bp.106.033761)
2006
- Harold, D. et al. 2006. Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. Molecular Psychiatry 11(12), pp. 1085-91. (10.1038/sj.mp.4001904)
- O'Donovan, M. et al. 2006. Genetic dissection of behavioural abnormalities in mouse models of DiGeorge/velocardiofacial syndrome. Journal of intellectual disability research 50(11), pp. 781 -781.
- Glaser, B. et al. 2006. Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility. Schizophrenia Research 87(1-3), pp. 21. (10.1016/j.schres.2006.05.024)
- Zammit, S. et al. 2006. Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia. Journal of Psychiatric Research 40(7), pp. 622-626. (10.1016/j.jpsychires.2005.05.006)
- Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(7), pp. 723-724.
- Li, Y. et al. 2006. DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Human Molecular Genetics 15(17), pp. 2560-2568. (10.1093/hmg/ddl178)
- Georgieva, L. et al. 2006. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 103(33), pp. 12469-12474. (10.1073/pnas.0603029103)
- Bray, N. J. and O'Donovan, M. C. 2006. Investigating cis-acting regulatory variation using assays of relative allelic expression. Psychiatric Genetics 16(4), pp. 173-177. (10.1097/01.ypg.0000218612.35139.84)
- Thapar, A., Langley, K., O'Donovan, M. C. and Owen, M. J. 2006. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 11(8), pp. 714-20. (10.1038/sj.mp.4001831)
- Talkowski, M. E. et al. 2006. Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. Biological psychiatry 60(2), pp. 152-162. (10.1016/j.biopsych.2006.02.015)
- Williams, J. and O'Donovan, M. C. 2006. The genetics of developmental dyslexia. European Journal of Human Genetics 14(6), pp. 681-89. (10.1038/sj.ejhg.5201575)
- Hamilton, G. et al. 2006. Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Neuroscience Letters 401(1-2), pp. 77-80. (10.1016/j.neulet.2006.03.021)
- Paylor, R. et al. 2006. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: Implications for 22q11 deletion syndrome. Proceedings of the National Academy of Sciences of the United States of America 103(20), pp. 7729-7734. (10.1073/pnas.0600206103)
- Williams, N. M. et al. 2006. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Archives of General Psychiatry 63(4), pp. 366-373. (10.1001/archpsyc.63.4.366)
- Escott-Price, V., Craddock, N. J., Holmans, P. A., Owen, M. J. and O'Donovan, M. C. 2006. Effects of differential genotyping error rate on the Type 1 error probability of case-control studies. Human heredity 61(1), pp. 55-64. (10.1159/000092553)
- Kirov, G., Nikolov, I., Georgieva, L., Escott-Price, V., Owen, M. J. and O'Donovan, M. C. 2006. Pooled DNA genotyping on Affymetrix SNP genotyping arrays. BMC Genomics 7(1), pp. 27-37. (10.1186/1471-2164-7-27)
- Harold, D. et al. 2006. A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacogenetics and genomics 16(2), pp. 75-77.
- Khan, I. A., Mort, M., Buckland, P. R., O'Donovan, M. C., Cooper, D. N. and Chuzhanova, N. A. 2006. In silico discrimination of single nucleotide polymorphisms and pathological mutations in human gene promoter regions by means of local DNA sequence context and regularity.. In silico Biology 6(1-2), pp. 23-34.
- Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2006. Chromosome 22 deletion syndrome and schizophrenia. International Review of Neurobiology 73, pp. 1-27. (10.1016/S0074-7742(06)73001-X)
- Smemo, S. et al. 2006. Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Annals of Neurology 59(1), pp. 21-26. (10.1002/ana.20673)
- Grupe, A. et al. 2006. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. The American Journal of Human Genetics 78(1), pp. 78-88.
- Peirce, T. R. et al. 2006. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of general psychiatry 63(1), pp. 18-24. (10.1001/archpsyc.63.1.18)
- Peirce, T. et al. 2006. Convergent evidence for 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of General Psychiatry 63(1), pp. 18-24.
- Norton, N. et al. 2006. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(1), pp. 96-101. (10.1002/ajmg.b.30236)
- Green, E. K. et al. 2006. Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation. Molecular Psychiatry 11(9), pp. 798-799. (10.1038/sj.mp.4001853)
- Hamshere, M. L. et al. 2006. Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes. Journal of Medical Genetics 43(7), pp. 563-567. (10.1136/jmg.2005.035345)
- Craddock, N. J., Owen, M. J. and O'Donovan, M. C. 2006. The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons. Molecular Psychiatry 11(5), pp. 446-458. (10.1038/sj.mp.4001808)
- Green, E. K. et al. 2006. Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK. British Journal of Psychiatry 188(1), pp. 21-25. (10.1192/bjp.bp.105.009969)
2005
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
- Gough, S. C. and O'Donovan, M. C. 2005. Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?. Journal of Psychopharmacology 19(6), pp. 47-55. (10.1177/0269881105058380)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
- Thapar, A., O'Donovan, M. C. and Owen, M. J. 2005. The genetics of attention deficit hyperactivity disorder. Human Molecular Genetics 14(2), pp. 275-282. (10.1093/hmg/ddi263)
- Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2005. Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?. Schizophrenia Bulletin 31(4), pp. 800-805. (10.1093/schbul/sbi061)
- Hamshere, M. L. et al. 2005. Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Archives of general psychiatry 62(10), pp. 1081-1088. (10.1001/archpsyc.62.10.1081)
- Buckland, P. R., Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K. and O'Donovan, M. C. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26(3), pp. 214-223. (10.1002/humu.20207)
- Williams, H. J. et al. 2005. No association between schizophrenia and polymorphisms in COMT in two large samples. American Journal of Psychiatry 162(9), pp. 1736-1738. (10.1176/appi.ajp.162.9.1736)
- Redfern, A. et al. 2005. Global gene expression profiling in the hippocampus and frontal cortex of Escitalopram-treated Learned Helplessness rats. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 138B(1), pp. 107-107.
- Nowotny, P. et al. 2005. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 136B(1), pp. 62-68. (10.1002/ajmg.b.30186)
- Glaser, B. et al. 2005. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. Biological psychiatry 58(1), pp. 78-80.
- Kirov, G., O'Donovan, M. C. and Owen, M. J. 2005. Finding schizophrenia genes. The Journal of Clinical Investigation 115(6), pp. 1440-1448. (10.1172/JCI24759)
- Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
- O'Donovan, M. C. 2005. An evaluation of chromatin condensation and DNA integrity in the spermatozoa of men with cancer before and after therapy. Andrologia -Berlin- 37(2-3), pp. 83-90. (10.1111/j.1439-0272.2005.00658.x)
- Green, E. K. et al. 2005. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Archives of general psychiatry 62(6), pp. 642-648. (10.1001/archpsyc.62.6.642)
- Norton, N. et al. 2005. No evidence for association between polymorphisms in GRM3 and schizophrenia. BMC Psychiatry 5, article number: 23. (10.1186/1471-244X-5-23)
- Holmans, P. A. et al. 2005. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B(1), pp. 24-32. (10.1002/ajmg.b.30114)
- Bray, N. J., Preece, A. C., Williams, N. M., Escott-Price, V., Buckland, P. R., Owen, M. J. and O'Donovan, M. C. 2005. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Human Molecular Genetics 14(14), pp. 1947-1954. (10.1093/hmg/ddi199)
- Cope, N. A. et al. 2005. Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. American Journal of Human Genetics 76(4), pp. 581-591. (10.1086/429131)
- Escott-Price, V., Norton, N., Williams, N. M., Holmans, P. A., Owen, M. J. and O'Donovan, M. C. 2005. Streamlined analysis of pooled genotype data in SNP-based association studies. Genetic Epidemiology 28(3), pp. 273-282. (10.1002/gepi.20062)
- Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K., Coleman, S. L. and O'Donovan, M. C. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162(3), pp. 613-615. (10.1176/appi.ajp.162.3.613)
- Li, Y. et al. 2005. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Human Mutation 25(3), pp. 270-277. (10.1002/humu.20138)
- Cope, N. A. et al. 2005. No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia. Molecular Psychiatry 10(3), pp. 237-238. (10.1038/sj.mp.4001596)
- Turic, D., Williams, H., Langley, K., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2005. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B(1), pp. 64-67. (10.1002/ajmg.b.30123)
- Owen, M. J., O'Donovan, M. C. and Harrison, P. J. 2005. Schizophrenia: a genetic disorder of the synapse?. British Medical Journal (BMJ) 330(7484), pp. 158-159. (10.1136/bmj.330.7484.158)
- Owen, M. J., Craddock, N. J. and O'Donovan, M. C. 2005. Schizophrenia: genes at last?. Trends in Genetics 21(9), pp. 518-525. (10.1016/j.tig.2005.06.011)
- Raybould, R. et al. 2005. Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biological psychiatry 57(7), pp. 696-701. (10.1016/j.biopsych.2005.01.018)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2005. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. Journal of Medical Genetics 42(3), pp. 193-204. (10.1136/jmg.2005.030718)
- Green, E. et al. 2005. Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease. American Journal of Psychiatry 162(1), pp. 35-42. (10.1176/appi.ajp.162.1.35)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2005. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophrenia Bulletin 32(1), pp. 9-16. (10.1093/schbul/sbj033)
- Kent, L. et al. 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10(10), pp. 939-943. (10.1038/sj.mp.4001696)
- Glaser, B., Kirov, G., Bray, N. J., Green, E., O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2005. Identification of a potential Bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. Molecular Psychiatry 10(10), pp. 920-927. (10.1038/sj.mp.4001689)
2004
- Buckland, P. R. et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690(3), pp. 238-249.
- Bray, N. J. et al. 2004. Allelic variation in the expression of neuropsychiatric candidate genes [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 25-25.
- Peirce, T. R. et al. 2004. Convergent functional genomics, association and linkage analysis suggests 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase (CNP) as a potential susceptibility gene for schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 81-81. (10.1002/ajmg.b.30101)
- Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
- Bray, N. J., Jehu, L., Escott-Price, V., Buckland, P. R., Williams, J., Owen, M. J. and O'Donovan, M. C. 2004. Allelic expression of APOE in brain [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 61-61.
- Norton, N. et al. 2004. Interaction between neuregulin 1 and its receptor ERBB4 increases susceptibility to schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 18-18.
- Mowry, B. J. et al. 2004. Multicenter linkage study of schizophrenia loci on chromosome 22q. Molecular Psychiatry 9(8), pp. 784-795. (10.1038/sj.mp.4001481)
- Morris, D. et al. 2004. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. American Journal Of Medical Genetics Part A 129B(1), pp. 97-103. (10.1002/ajmg.b.30033)
- Zammit, S. et al. 2004. Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. American Journal of Medical Genetics 128B(1), pp. 19-20. (10.1002/ajmg.b.30021)
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2004. Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation 24(1), pp. 35-42. (10.1002/humu.20061)
- Bray, N. J., Jehu, L., Escott-Price, V., Buckland, P. R., Owen, M. J., Williams, J. and O'Donovan, M. C. 2004. P4-101 Allelic expression of APOE in brain [Conference Abstract]. Neurobiology of Aging 25, pp. S503-S503. (10.1016/S0197-4580(04)81659-2)
- Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
- Plomin, R. et al. 2004. A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability. Molecular Psychiatry 9(6), pp. 582-586. (10.1038/sj.mp.4001441)
- Turic, D., Langley, K., Kirov, G., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2004. Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD. American Journal of Medical Genetics 127B(1), pp. 68-72. (10.1002/ajmg.b.20173)
- Kirov, G. et al. 2004. Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biological psychiatry 55(10), pp. 971-975. (10.1016/j.biopsych.2004.01.025)
- Owen, M. J., Williams, N. M. and O'Donovan, M. C. 2004. Dysbindin-1 and schizophrenia: from genetics to neuropathology. The Journal of Clinical Investigation 113(9), pp. 1255-1257. (10.1172/JCI200421470)
- Murphy, K., Williams, H., Owen, M. J. and O'Donovan, M. C. 2004. What can velo-cardio-facial syndrome tell us about the genetics of schizophrenia?. European Psychiatry 19(Supp1), pp. 96S-96S.
- Williams, N. M. et al. 2004. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Archives of General Psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
- Huezo-Diaz, P. et al. 2004. An association study of the neurotensin receptor gene with schizophrenia and clozapine response. Schizophrenia Research 66(2-3), pp. 193-195. (10.1016/S0920-9964(03)00128-2)
- Williams, N. M. et al. 2004. Support for RGS4 as a susceptibility gene for schizophrenia. Biological Psychiatry 55(2), pp. 192-195. (10.1016/j.biopsych.2003.11.002)
- Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
- Williams, N. M. et al. 2004. Identification in two independent samples of a novel schizophrenia risk haplotype of the dystobrevin binding protein gene (DTNBP1). Archives of general psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
- Guy, C., Hoogendoorn, B., Smith, S. K., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2004. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 14(1), pp. 45-51. (10.1097/00008571-200401000-00005)
- Owen, M. J., Williams, N. M. and O'Donovan, M. C. 2004. The molecular genetics of schizophrenia: new findings promise new insights. Molecular Psychiatry 9(1), pp. 14-27. (10.1038/sj.mp.4001444)
- Myers, A. J. et al. 2004. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics 124B(1), pp. 29-37. (10.1002/ajmg.b.20036)
- Cichon, S. et al. 2004. Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nature Genetics 36(8), pp. 783-784. (10.1038/ng0804-783)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)
- Norton, N., Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2004. DNA pooling as a tool for large-scale association studies in complex traits. Annals of Medicine 36(2), pp. 146-152. (10.1080/07853890310021724)
- Busby, V. et al. 2004. Alpha-T-Catenin Is Expressed in Human Brain and Interacts With the Wnt Signaling Pathway But Is Not Responsible for Linkage to Chromosome 10 in Alzheimer's Disease. Neuromolecular Medicine 5(2), pp. 133-146. (10.1385/NMM:5:2:133)
- Bray, N. J., Buckland, P. R., Hall, H., Owen, M. J. and O'Donovan, M. C. 2004. The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Molecular Psychiatry 9(1), pp. 109-114. (10.1038/sj.mp.4001366)
- Bray, N. J. et al. 2004. Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes. Human Molecular Genetics 13(22), pp. 2885-2892. (10.1093/hmg/ddh299)
2003
- Williams, N. M. et al. 2003. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. The American journal of human genetics 73(6), pp. 1355-1367. (10.1086/380206)
- Smith, S. K., Hoogendoorn, B., Guy, C., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2003. Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission. Psychiatric Genetics 13(4), pp. 193-199. (10.1097/00041444-200312000-00001)
- Ivanov, D. et al. 2003. Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis: Molecular genetic study. The British Journal of Psychiatry 183(5), pp. 409-413. (10.1192/bjp.183.5.409)
- Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
- O'Donovan, M. C., Williams, N. M. and Owen, M. J. 2003. Recent advances in the genetics of schizophrenia. Human Molecular Genetics 12(suppl), pp. R125-R133. (10.1093/hmg/ddg302)
- Kirov, G. et al. 2003. Variation in the protocadherin - A gene cluster?. Genomics 82(4), pp. 433-440. (10.1016/S0888-7543(03)00167-8)
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., Bowen, T., Buckland, P. R. and O'Donovan, M. C. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12(18), pp. 2249-2254. (10.1093/hmg/ddg246)
- Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
- Harold, D. et al. 2003. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Human Genetics 113(3), pp. 258-267. (10.1007/s00439-003-0960-2)
- Norton, N. et al. 2003. Mutation screening of the Homer gene family and association analysis in schizophrenia. American Journal of Medical Genetics 120B(1), pp. 18-21. (10.1002/ajmg.b.20032)
- Williams, H. et al. 2003. Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia. American Journal of Medical Genetics 120B(1), pp. 42-46. (10.1002/ajmg.b.20049)
- Williams, H. J. et al. 2003. Association between PRODH and schizophrenia is not confirmed. Molecular Psychiatry 8(7), pp. 644-645. (10.1038/sj.mp.4001276)
- Lewis, C. M. et al. 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder, Part II: schizophrenia. American Journal of Human Genetics 73(1), pp. 34-48. (10.1086/376549)
- Bray, N. J., Buckland, P. R., Williams, N. M., Williams, H. J., Norton, N., Owen, M. J. and O'Donovan, M. C. 2003. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. The American Journal of Human Genetics 73(1), pp. 152-161. (10.1086/376578)
- Bray, N. B., Buckland, P. R., Owen, M. J. and O'Donovan, M. C. 2003. Cis-acting variation in the expression of a high proportion of genes in human brain. Human Genetics 113(2), pp. 149-153. (10.1007/s00439-003-0956-y)
- Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13(2), pp. 107-110. (10.1097/01.ypg.0000056177.32550.a5)
- Williams, N. M. et al. 2003. Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Molecular Psychiatry 8(5), pp. 485-487. (10.1038/sj.mp.4001348)
- Turic, D. et al. 2003. Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22. Molecular Psychiatry 8(2), pp. 176-185. (10.1038/sj.mp.4001216)
- Lawson, D. C. et al. 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B(1), pp. 84-89. (10.1002/ajmg.b.10002)
- O'Donovan, M. C., Jones, I. R. and Craddock, N. J. 2003. Anticipation and repeat expansion in bipolar disorder. American Journal of Medical Genetics 123C(1), pp. 10-17. (10.1002/ajmg.c.20009)
- O'Donovan, M. C. and Owen, M. J. 2003. Genetic findings in psychotic disorders. In: Soares, J. C. and Gershon, S. eds. Handbook of Medical Psychiatry. New York: Marcel Dekker, pp. 417-432.
- Owen, M. J. and O'Donovan, M. C. 2003. Schizophrenia and genetics. In: Plomin, R. et al. eds. Behavioral Genetics in the Postgenomic Era. Washington, DC: APA Books, pp. 463-480., (10.1037/10480-023)
- Buckland, P. R., Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2003. A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expression 11(5), pp. 233-239. (10.3727/000000003783992225)
2002
- Sham, P., Bader, J. S., Craig, I., O'Donovan, M. C. and Owen, M. J. 2002. DNA Pooling: a tool for large-scale association studies. Nature Reviews Genetics 3(11), pp. 862-871. (10.1038/nrg930)
- Bray, N. J. et al. 2002. Screening the protocadherin 8 (PCDH8) gene in schizophrenia [Conference Abstract]. American Journal of Medical Genetics 114(7), pp. 844-844.
- Bray, N. J., Buckland, P. R., Williams, H., Norton, N., Williams, N. M., Owen, M. J. and O'Donovan, M. C. 2002. Detection of cis-acting polymorphisms and epigenetic modification affecting gene expression [Conference Abstracts]. American Journal of Medical Genetics 114(7), pp. 750-750. (10.1002/ajmg.10971)
- Bray, N. J. et al. 2002. Screening the human protocadherin 8 (PCDH8) gene in schizophrenia. Genes, Brain and Behavior 1(3), pp. 187-191. (10.1034/j.1601-183X.2002.10307.x)
- Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2002. Streamlined approach to functional analysis of promoter-region polymorphisms. Biotechniques 33(2), pp. 412-418.
- Norton, N. et al. 2002. Schizophrenia and functional polymorphisms in the MAOA and COMT genes: No evidence for association or epistasis. American Journal Of Medical Genetics Part A 114(5), pp. 491-496. (10.1002/ajmg.10517)
- Norton, N. et al. 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110(5), pp. 471-478. (10.1007/s00439-002-0706-6)
- Levinson, D. F. et al. 2002. No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science 296(5568), pp. 739-741. (10.1126/science.1069914)
- Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7(5), pp. 493-502. (10.1038/sj.mp.4001003)
- Coleman, S. L., Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2002. Experimental analysis of the annotation of promoters in the public database. Human Molecular Genetics 11(16), pp. 1817-1821. (10.1093/hmg/11.16.1817)
- Williams, N. M. et al. 2002. Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach. Molecular Psychiatry 7(10), pp. 1092-1100. (10.1038/sj.mp.4001188)
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7(5), pp. 508-514. (10.1038/sj.mp.4001030)
- Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2002. Genome scans and microarrays: converging on genes for schizophrenia?. Genome Biology 3(4), pp. Reviews1011-Reviews1011.5.
- West, A. et al. 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7(9), pp. 962-966. (10.1038/sj.mp.4001129)
- Hawi, Z. et al. 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Molecular Psychiatry 7(7), pp. 718-725. (10.1038/sj.mp.4001048)
- Zammit, S., O'Donovan, M. C. and Owen, M. J. 2002. Neurogenetics of schizophrenia. In: D'haenen, H., den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley, pp. 663-671., (10.1002/0470854871.chxvii9)
- Thapar, A. and O'Donovan, M. C. 2002. Neurogenetics. In: D'haenen, H., den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley, pp. 167-180., (10.1002/0470854871.chxii)
2001
- Jurewicz, I., Owen, R., O'Donovan, M. C. and Owen, M. J. 2001. Searching for susceptibility genes in schizophrenia. European Neuropsychopharmacology 11(6), pp. 395-398. (10.1016/S0924-977X(01)00116-X)
- Abraham, R. et al. 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109(6), pp. 646-652. (10.1007/s00439-001-0614-1)
- Kirov, G., Lowry, C. A., Stephens, M., Oldfield, S., O'Donovan, M. C., Lightman, S. L. and Owen, M. J. 2001. Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder. Molecular Psychiatry 6(6), pp. 671-677. (10.1038/sj.mp.4000899)
- Williams, H. et al. 2001. Association analysis of TBX1 and schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 105(7), pp. 561.
- Payton, A. et al. 2001. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. Neuroscience Letters 105(5), pp. 464-470. (10.1002/ajmg.1407)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6(3), pp. 259-260. (10.1038/sj.mp.4000128)
- Jacobsen, N. J. O., Elvidge, G., Franks, E. K. E., O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2001. CUX2, a potential regulator of NCAM expression: Genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder. American Journal of Medical Genetics 105(3), pp. 295-300. (10.1002/ajmg.1325)
- Jacobsen, N. J. O. et al. 2001. Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder. Molecular Psychiatry 6(1), pp. 92-97. (10.1038/sj.mp.4000774)
- Williams, N. et al. 2001. Screening of candidate genes related to myelination for mutations associated with schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 105(7), pp. 589.
2000
- Vincent, J. B. et al. 2000. Long repeat tracts at SCA8 in major psychosis. American Journal of Medical Genetics 96(6), pp. 873-876. (10.1002/1096-8628(20001204)96:6<873::AID-AJMG37>3.0.CO;2-9)
- Bowen, T. et al. 2000. No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder. Bipolar Disorders 2(4), pp. 328-331. (10.1034/j.1399-5618.2000.020406.x)
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Williams, H., Murphy, K., Spurlock, G., O'Donovan, M. and Owen, M. 2000. No association of the -277A variant allele of the UFD1L promoter polymorphism and schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96(4), pp. 533-534.
- Bray, N. J. et al. 2000. No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia. Psychiatric Genetics 10(2), pp. 83-86. (10.1097/00041444-200010020-00005)
- Morris, D. W. et al. 2000. Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q. Human Molecular Genetics 9(5), pp. 843-848. (10.1093/hmg/9.5.843)
- Austin, J. et al. 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10(1), pp. 51-54. (10.1097/00041444-200010010-00009)
- Austin, J. et al. 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5(2), pp. 208-212. (10.1038/sj.mp.4000693)
- Bowen, T. et al. 2000. Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia. Psychiatric Genetics 10(1), pp. 33-37. (10.1097/00041444-200010010-00006)
- Owen, M. J., Cardno, A. G. and O'Donovan, M. C. 2000. Psychiatric genetics: back to the future. Molecular Psychiatry 5(1), pp. 22-31. (10.1038/sj.mp.4000702)
- Kirov, G., Stephens, M., Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2000. Automated genotyping of single-nucleotide polymorphisms by extension of fluorescently labelled primers: analysis of individual and pooled DNA samples. Balkan Journal of Medical Genetics 3, pp. 23-28.
- Cardno, A. G., O'Donovan, M. C. and Owen, M. J. 2000. Genetic risk factors for schizophrenia. International Journal of Mental Health 29(3), pp. 13-38.
- Williams, N. et al. 2000. Identification and characterisation of SNPs in candidate genes for schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96(4), pp. 462.
- Williams, N. et al. 2000. Linkage disequilibrium mapping and candidate gene screening of the VCFS deleted region for mutations associated with schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96(4), pp. 475.
- Speight, G. et al. 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5(3), pp. 327-331. (10.1038/sj.mp.4000717)
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)
1999
- O'Donovan, M. C. and Owen, M. J. 1999. Candidate-gene association studies of schizophrenia. American Journal of Human Genetics 65(3), pp. 587-592. (10.1086/302560)
- Jacobsen, N. J. et al. 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8(9), pp. 1631-1636. (10.1093/hmg/8.9.1631)
- Guy, C., Bowen, T., Jones, I. R., McCandless, F., Owen, M. J., Craddock, N. J. and O'Donovan, M. C. 1999. CTG18.1 and ERDA-1 CAG/CTG repeat size in bipolar disorder. Neurobiology of Disease 6(4), pp. 302-307. (10.1006/nbdi.1999.0249)
- Jones, A. C., Austin, J., Hansen, N., Hoogendoorn, B., Oefner, P. J., Cheadle, J. P. and O'Donovan, M. C. 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45(8), pp. 1133-1140.
- Cardno, A. G. et al. 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45(12), pp. 1592-1596. (10.1016/s0006-3223(99)00033-5)
- Sakuntabhai, A. et al. 1999. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nature Genetics 21(3), pp. 271-277.
- Franks, E., Guy, C., Jacobsen, N., Bowen, T., Owen, M. J., O'Donovan, M. C. and Craddock, N. J. 1999. Eleven trinucleotide repeat loci that map to chromosome 12 excluded from involvement in the pathogenesis of bipolar disorder. American Journal of Medical Genetics 88(1), pp. 67-70. (10.1002/(SICI)1096-8628(19990205)88:1<67::AID-AJMG12>3.0.CO;2-#)
- Guy, C. et al. 1999. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88(1), pp. 57-60. (10.1002/(sici)1096-8628(19990205)88:1%3C57::aid-ajmg10%3E3.0.co;2-6)
- Hoogendoorn, B., Owen, M. J., Oefner, P. J., Williams, N. M., Austin, J. and O'Donovan, M. C. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104(1), pp. 89-93. (10.1007/s004390050915)
1998
- Li, T. et al. 1998. Analysis of CAG/CTG repeat size in Chinese subjects with schizophrenia and bipolar affective disorder using the repeat expansion detection method. Biological psychiatry 44(11), pp. 1160-1165. (10.1016/S0006-3223(97)00492-7)
- O'Donovan, M. C. et al. 1998. Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection. Genomics 52(1), pp. 44-49. (10.1006/geno.1998.5411)
- Bowen, T. et al. 1998. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Molecular Psychiatry 3(3), pp. 266-269. (10.1038/sj.mp.4000400)
- Oretti, R. G., O'Donovan, M. C., McGuffin, P. and Buckland, P. R. 1998. Tryptophan pyrrolase gene expression in an alcohol preferring and non-preferring mouse strain. Addiction Biology 3(1), pp. 71-77. (10.1080/13556219872362)
- Bowen, T. et al. 1998. Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder. Molecular Psychiatry 3(1), pp. 67-71. (10.1038/sj.mp.4000293)
- Cardno, A. G. et al. 1998. Association between functional psychosis and expanded CAG/CTG repeats is not explained by health stratification [comparative study]. Psychiatric Genetics 8(1), pp. 29-32. (10.1097/00041444-199800810-00005)
1997
- Jones, L. et al. 1997. No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia. Molecular Psychiatry 2(6), pp. 478-482. (10.1038/sj.mp.4000297)
- Craddock, N. J. et al. 1997. Expanded CAG/CTG repeats in bipolar disorder: no correlation with phenotypic measures of illness severity. Biological psychiatry 42(10), pp. 876-881. (10.1016/s0006-3223(96)00516-1)
- Guy, C. et al. 1997. Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder. American Journal of Psychiatry 154(8), pp. 1146-1147.
- Speight, G. et al. 1997. Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia. American Journal of Medical Genetics 74(2), pp. 204-206. (10.1002/(SICI)1096-8628(19970418)74:2<204::AID-AJMG19>3.0.CO;2-M)
- O'Donovan, M. C. and Guy, C. 1997. Bias in the genomic distribution of CAG and CTG trinucleotide repeats. American Journal of Medical Genetics 74(1), pp. 62-64. (10.1002/(SICI)1096-8628(19970221)74:1<62::AID-AJMG14>3.0.CO;2-P)
1996
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 1996. Introducing Selfcite 2.0--career enhancing software. BMJ 313(7072), pp. 1659-1660. (10.1136/bmj.313.7072.1659)
- Cardno, A. G. et al. 1996. Expanded CAG/CTG repeats in schizophrenia. A study of clinical correlates. British Journal of Psychiatry 169(6), pp. 766-771. (10.1192/bjp.169.6.766)
- O'Donovan, M. C., Craddock, N. J., Guy, C., McGuffin, P. and Owen, M. J. 1996. Involvement of expanded trinucleotide repeats in common diseases. The Lancet 348(9043), pp. 1739-1740. (10.1016/s0140-6736(05)65870-9)
- O'Donovan, M. C. et al. 1996. Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychological Medicine -London- 26(6), pp. 1145-1153. (10.1017/s0033291700035868)
- Bowen, T. et al. 1996. Expansion of 50 CAG/CTG repeats excluded in schizophrenia by application of a highly efficient approach using repeat expansion detection and a PCR screening set. American Journal of Human Genetics 59(4), pp. 912-917.
- O'Donovan, M. C. 1996. Genetics of Mental disorders .1. Theoretical aspects - Mendlewicz,J, Papadimitriou,GN. British Journal of Psychiatry 168(2), pp. 256-256.
- O'Donovan, M. C. and Owen, M. J. 1996. Dynamic mutations and psychiatric genetics. Psychological Medicine 26(1), pp. 1-6. (10.1017/S0033291700033663)
1995
- O'Donovan, M. C. et al. 1995. Expanded CAG repeats in schizophrenia and bipolar disorder [letter]. Nature Genetics 10(4), pp. 380-381. (10.1038/ng0895-380)
1994
- Thapar, A., Gottesman, I. I., Owen, M. J., O'Donovan, M. C. and McGuffin, P. 1994. The genetics of mental retardation. The British Journal of Psychiatry 164(6), pp. 747. (10.1192/bjp.164.6.747)
- McGuffin, P., Owen, M. J., O'Donovan, M. C., Thapar, A. and Gottesman, I. I. 1994. Seminars in psychiatric genetics. Gaskell, Royal College of Psychiatrists.
- Spurlock, G., Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1994. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter. Neuropharmacology 33(3-4), pp. 433-440. (10.1016/0028-3908(94)90073-6)
1993
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1993. Clozapine and sulpiride up-regulate dopamine D3 receptor mRNA levels. Neuropharmacology 32(9), pp. 901-907. (10.1016/0028-3908(93)90146-T)
- McGuffin, P. and O'Donovan, M. C. 1993. Taking a balanced view on triazolam. British Medical Journal (BMJ) 306(6893), pp. 1690-1691. (10.1136/bmj.306.6893.1690-c)
- O'Donovan, M. C. and McGuffin, P. 1993. Correction: Short acting benzodiazepines. British Medical Journal (BMJ) 306(6886), pp. 1146-1146. (10.1136/bmj.306.6886.1146)
- O'Donovan, M. C. and McGuffin, P. 1993. Short acting benzodiazepines.. British Medical Journal (BMJ) 306(6883), pp. 945-946. (10.1136/bmj.306.6883.945)
- O'Donovan, M. C. 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72(6), pp. 971-983. (10.1016/0092-8674(93)90585-E)
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1993. Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs. Neuroscience Letters 150(1), pp. 25-28. (10.1016/0304-3940(93)90099-7)
1992
- O'Donovan, M. C., Buckland, P. R., Spurlock, G. and McGuffin, P. 1992. Bi-directional changes in the levels of messenger RNAs encoding γ-aminobutyric acidA receptor α subunits after flurazepam treatment. European Journal of Pharmacology: Molecular Pharmacology 226(4), pp. 335-341. (10.1016/0922-4106(92)90051-V)
- O'Donovan, M. C. and Owen, M. J. 1992. Advances and Retreats in the Molecular Genetics of Major Mental Illness. Annals of Medicine 24(3), pp. 171-177. (10.3109/07853899209147816)
- O'Donovan, M. C., Buckland, P. R. and McGuffin, P. 1992. Levels of GABAa receptor subunit mRNA in rat brain following flurazepam treatment. Journal of Psychopharmacology 6(3), pp. 364-369. (10.1177/026988119200600304)
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1992. Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 106(4), pp. 479-483. (10.1007/BF02244818)
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1992. Changes in dopa decarboxylase mRNA but not tyrosine hydroxylase mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 108(1-2), pp. 98-102. (10.1007/BF02245292)
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1992. Lack of effect of chronic antipsychotic treatment on dopamine D5 receptor mRNA level. European Neuropsychopharmacology 2(4), pp. 405-409. (10.1016/0924-977X(92)90002-P)
- O'Donovan, M. C., Buckland, P. R. and McGuffin, P. 1992. The expression of neuroreceptor genes and benzodiazepine tolerance.. Clinical Neuropharmacology 15(Supp1), pp. 218A-219A. (10.1097/00002826-199201001-00114)
1991
- O'Donovan, M. C. and McGuffin, P. 1991. Growing points in psychiatric genetics. British Journal of Hospital Medicine 46(6), pp. 359-360.
- Havard, H. L., Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1991. The effects of antidepressant drugs on kainate receptor mRNA levels. Neuropharmacology 30(6), pp. 675-677. (10.1016/0028-3908(91)90090-X)
- O'Donovan, M. C. and Buckland, P. R. 1991. Simultaneous quantification of several mRNA species by solution hybridisation with oligonucleotides. Nucleic Acids Research 19(12), pp. 3466. (10.1093/nar/19.12.3466)
1989
- Espie, C., Pashley, A., Bonham, K., Sourindhrin, I. and O'Donovan, M. C. 1989. The mentally handicapped person with epilepsy: a comparative study investigating psychosocial functioning.. Journal of Mental Health Defiency Research 33(2), pp. 123-135.
Articles
- Dempster, E. et al. 2024. Methylomic signature of current cannabis use in two first-episode psychosis cohorts. Molecular Psychiatry (10.1038/s41380-024-02689-0)
- Koch, E. et al. 2024. How real-world data can facilitate the development of precision medicine treatment in psychiatry. Biological Psychiatry 96(7), pp. 543-551. (10.1016/j.biopsych.2024.01.001)
- Tume, C. E., Chick, S. L., Holmans, P. A., Rees, E., O'Donovan, M. C., Cameron, D. and Bray, N. J. 2024. Genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. Biological Psychiatry 4(5), article number: 100345. (10.1016/j.bpsgos.2024.100345)
- Cameron, D. et al. 2024. Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia. Schizophrenia Bulletin Open 50(5), pp. 1171-1184. (10.1093/schbul/sbae083)
- González-Peñas, J. et al. 2024. Accelerated cortical thinning in schizophrenia is associated with rare and common predisposing variation to schizophrenia and neurodevelopmental disorders. Biological Psychiatry 96(5), pp. 376-389. (10.1016/j.biopsych.2024.03.011)
- Legge, S. E. et al. 2024. Genetic and phenotypic features of Schizophrenia in the UK Biobank. JAMA Psychiatry 81, pp. 681-690. (10.1001/jamapsychiatry.2024.0200)
- Trastulla, L. et al. 2024. Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications 15, article number: 5534. (10.1038/s41467-024-49338-2)
- Frei, O. et al. 2024. Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets. Nature Genetics 56, pp. 1310-1318. (10.1038/s41588-024-01771-1)
- D'Andrea, G. et al. 2024. Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study. Psychological Medicine 54(8), pp. 1810-1823. (10.1017/S0033291723003781)
- Owen, M. and O'Donovan, M. 2024. The genetics of cognition in schizophrenia.. Brain Medicine
- Stevenson-Hoare, J. et al. 2024. Severe psychiatric disorders are associated with increased risk of dementia. BMJ Mental Health 27(1), article number: e301097. (10.1136/bmjment-2024-301097)
- Clifton, N. E., Lin, J. Q., Holt, C. E., O’Donovan, M. C. and Mill, J. 2024. Enrichment of the local synaptic translatome for genetic risk associated with schizophrenia and autism spectrum disorder. Biological Psychiatry 95(9), pp. 888-895. (10.1016/j.biopsych.2023.12.006)
- van der Meer, D. et al. 2024. Clustering schizophrenia genes by their temporal expression patterns aids functional interpretation. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders 50(2), pp. 327-338. (10.1093/schbul/sbad140)
- Kappel, D. et al. 2024. Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia. European Neuropsychopharmacology 80, pp. 47-54. (10.1016/j.euroneuro.2023.12.007)
- Shakeshaft, A., Martin, J., Dennison, C. A., Riglin, L., Lewis, C. M., O'Donovan, M. and Thapar, A. 2024. Estimating the impact of transmitted and non-transmitted psychiatric and neurodevelopmental polygenic scores on youth emotional problems. Molecular Psychiatry 29, pp. 238-246. (10.1038/s41380-023-02319-1)
- Dennison, C. et al. 2024. Stratifying early-onset emotional disorders: using genetics to assess persistence in young people of European and South Asian ancestry. Journal of Child Psychology and Psychiatry 65(1), pp. 42-51. (10.1111/jcpp.13862)
- Schipper, M., Leeuw, C., Maciel, B., Wightman, H., Boomsma, D., O’Donovan, M. and Posthuma, D. 2024. Gene prioritization in GWAS loci using multimodal evidence. Nature Genetics
- O'Connell, K. et al. 2024. Genomics yields biological and phenotypic insights into bipolar disorder. Biological Psychiatry
- Owen, M. J. and O'Donovan, M. C. 2024. The genetics of cognition in schizophrenia. Genomic Psychiatry (10.61373/gp024i.0040)
- Wang, S. et al. 2023. Rare X-linked variants carry predominantly male risk in Autism, Tourette Syndrome, and ADHD. Nature Communications 14, article number: 8077. (10.1038/s41467-023-43776-0)
- Spinazzola, E. et al. 2023. The association between reasons for first using cannabis, later pattern of use, and risk of first-episode psychosis: the EU-GEI case-control study. Psychological Medicine 53(15), pp. 7418-7427. (10.1017/S0033291723001071)
- Yuan, K. et al. 2023. Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases. European Neuropsychopharmacology 75(Supp 1), pp. S6-S7. (10.1016/j.euroneuro.2023.08.021)
- Lock, S. K. et al. 2023. Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count. Schizophrenia 9, article number: 74. (10.1038/s41537-023-00404-6)
- Toste, C., O'Donovan, M. and Bray, N. 2023. Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits. Human Molecular Genetics 32(20), pp. 2941-2949., article number: ddad118. (10.1093/hmg/ddad118)
- Doherty, A., O'Donovan, M., Hamshere, M., Jones, I., Owen, M. and Walters, J. 2023. Genome-wide association study meta-analysis of suicide attempt identifies twelve genome-wide significant loci and implicates genetic risks for specific health factors. The American Journal of Psychiatry 180(10), pp. 723-738. (10.1176/appi.ajp.21121266)
- Clifton, N., Schulmann, A., Schizophrenia Working Group of the Psychiatric Genomics Consorti, ., Holmans, P., O'Donovan, M. and Vawter, M. 2023. The relationship between case-control differential gene expression from brain tissue and genetic associations in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 192(5-6), pp. 85-92. (10.1002/ajmg.b.32931)
- Owen, M., Legge, S., Rees, E., Walters, J. and O'Donovan, M. 2023. Genomic findings in schizophrenia and their implications. Molecular Psychiatry 28, pp. 3638-3647. (10.1038/s41380-023-02293-8)
- Le Guen, Y. et al. 2023. Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes. Proceedings of the National Academy of Sciences 120(36), article number: e2302720120. (10.1073/pnas.2302720120)
- Ollà, I. et al. 2023. Pathogenic mis-splicing of CPEB4 in schizophrenia. Biological Psychiatry 94(4), pp. 341-351. (10.1016/j.biopsych.2023.03.010)
- Maury, E. A. et al. 2023. Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions. Cell Genomics 3(8), article number: 100356. (10.1016/j.xgen.2023.100356)
- Allardyce, J. et al. 2023. Specificity of polygenic signatures across symptom dimensions in bipolar disorder: an analysis of UK Bipolar Disorder Research Network data. The Lancet Psychiatry 10(8), pp. 623-631. (10.1016/S2215-0366(23)00186-4)
- Lewis, K. et al. 2023. The dynamic interplay between sleep and mood: an intensive longitudinal study of individuals with bipolar disorder. Psychological Medicine 53(8), pp. 3345-3354. (10.1017/S0033291721005377)
- Rodriguez, V. et al. 2023. Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample; the EU-GEI study. Psychological Medicine 53(8), pp. 3396-3405. (10.1017/S0033291721005456)
- Demontis, D. et al. 2023. Author Correction: Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nature Genetics 55, article number: 730. (10.1038/s41588-023-01350-w)
- Johnson, E. C. et al. 2023. Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder. Psychological Medicine 53(4), pp. 1196-1204. (10.1017/S003329172100266X)
- Lynham, A. J. et al. 2023. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open 9(2), article number: e32. (10.1192/bjo.2022.636)
- Pardinas, A. F. et al. 2023. Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical monitoring data. The Lancet Psychiatry 10(3), pp. 209-219. (10.1016/S2215-0366(23)00002-0)
- Dimitriadis, S. I. et al. 2023. Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk. Cerebral Cortex 33(6), pp. 2997-3011. (10.1093/cercor/bhac256)
- Liu, D. et al. 2023. Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations. Nature Genetics 55, pp. 369-376. (10.1038/s41588-023-01305-1)
- Demontis, D. et al. 2023. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nature Genetics 55, pp. 198-208. (10.1038/s41588-022-01285-8)
- Ajnakina, O. et al. 2023. Development and validation of predictive model for a diagnosis of first episode psychosis using the multinational EU-GEI case-control study and modern statistical learning methods.. Schizophrenia Bulletin Open 4(1), article number: sgad008. (10.1093/schizbullopen/sgad008)
- Cameron, D. et al. 2023. Single nuclei RNA sequencing of 5 regions of the human prenatal brain implicates developing neuron populations in genetic risk for schizophrenia. Biological Psychiatry 93, pp. 157-166. (10.1016/j.biopsych.2022.06.033)
- Kappel, D. B. et al. 2023. Genomic stratification of clozapine prescription patterns using schizophrenia polygenic scores. Biological Psychiatry 93, pp. 149-156. (10.1016/j.biopsych.2022.07.014)
- Martin, J. et al. 2023. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biological Psychiatry 93(1), pp. 37-44. (10.1016/j.biopsych.2022.06.008)
- Crawford, K. et al. 2022. Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing. Molecular Psychiatry (10.1038/s41380-022-01926-8)
- Riglin, L. et al. 2022. Early manifestations of genetic liability for ADHD, autism and schizophrenia at ages 18 and 24 months. JCPP Advances 2(3), article number: e12093. (10.1002/jcv2.12093)
- Bracher-Smith, M. et al. 2022. Machine learning for prediction of schizophrenia using genetic and demographic factors in the UK Biobank. Schizophrenia Research 246, pp. 156-164. (10.1016/j.schres.2022.06.006)
- Richards, A. et al. 2022. Genetic liabilities differentiating bipolar disorder, schizophrenia and major depression and phenotypic heterogeneity in bipolar disorder. JAMA Psychiatry 79(10), pp. 1032-1039. (10.1001/jamapsychiatry.2022.2594)
- Creeth, H. D. J. et al. 2022. Ultrarare coding variants and cognitive function in schizophrenia. JAMA Psychiatry 79(10), pp. 963-970. (10.1001/jamapsychiatry.2022.2289)
- Riglin, L. et al. 2022. “Late-onset” ADHD symptoms in young adulthood: is this the same as child-onset ADHD?. Journal of Attention Disorders 26(10), pp. 1271-1282. (10.1177/10870547211066486)
- Paquin, V. et al. 2022. Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population. Social Psychiatry and Psychiatric Epidemiology (10.1007/s00127-022-02346-3)
- van Os, J. et al. 2022. Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway. Psychological Medicine 52(10), pp. 1910-1922. (10.1017/S0033291720003748)
- Henquet, C. et al. 2022. A replication study of JTC bias, genetic liability for psychosis and delusional ideation. Psychological Medicine 52(9), pp. 1777-1783. (10.1017/S0033291720003578)
- Morris, E., O'Donovan, M., Virani, A. and Austin, J. 2022. An ethical analysis of divergent clinical approaches to the application of genetic testing for autism and schizophrenia. Human Genetics 141, pp. 1069-1084. (10.1007/s00439-021-02349-1)
- Palmer, D. et al. 2022. Exome sequencing in bipolar disorder reveals AKAP11 as a risk gene shared with schizophrenia. Nature Genetics (10.1038/s41588-022-01034-x)
- Bellenguez, C. et al. 2022. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics 54(4), pp. 412-436. (10.1038/s41588-022-01024-z)
- Trubetskoy, V. et al. 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604, pp. 502-508. (10.1038/s41586-022-04434-5)
- Singh, T., Schizophrenia Exome Meta-Analysis (SCHEMA) Consortium, ., Kirov, G., Rees, E., Walters, J., Owen, M. and O'Donovan, M. 2022. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature 604, pp. 509-516. (10.1038/s41586-022-04556-w)
- Lancaster, T., Dimitriadis, S., Perry, G., Zammit, S., O'Donovan, M. and Linden, D. 2022. Morphometric analysis of structural MRI using schizophrenia meta-analytic priors distinguish patients from controls in two independent samples and in a sample of individuals with high polygenic risk. Schizophrenia Bulletin 48(2), pp. 524-532., article number: sbab125. (10.1093/schbul/sbab125)
- Fusar-Poli, L. et al. 2022. Examining facial emotion recognition as an intermediate phenotype for psychosis: findings from the EUGEI study. Progress in Neuro-Psychopharmacology and Biological Psychiatry 113, article number: 110440. (10.1016/j.pnpbp.2021.110440)
- Mullins, N. et al. 2022. Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors. Biological Psychiatry 91(3), pp. 313-327. (10.1016/j.biopsych.2021.05.029)
- Jones, H. J. et al. 2022. Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence. Psychological Medicine 52(1), pp. 132-139. (10.1017/S0033291720001798)
- Vassos, E. et al. 2022. Lack of support for the genes by early environment interaction hypothesis in the pathogenesis of schizophrenia. Schizophrenia Bulletin 48(1), pp. 20-26. (10.1093/schbul/sbab052)
- Sanders, B. et al. 2022. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature Communications 13(1), article number: 27. (10.1038/s41467-021-27601-0)
- Pardinas, A. et al. 2022. Interaction testing and polygenic risk scoring to estimate the contribution of common genetic variants to treatment resistance in schizophrenia. JAMA Psychiatry 79(3), pp. 260-269. (10.1001/jamapsychiatry.2021.3799)
- Dimitriadis, S. I. et al. 2021. Global brain flexibility during working memory is reduced in a high genetic risk group for schizophrenia. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 6(12), pp. 1176-1184. (10.1016/j.bpsc.2021.01.007)
- Di Florio, A. et al. 2021. Post-partum psychosis and its association with bipolar disorder in the UK: a case-control study using polygenic risk scores. The Lancet Psychiatry 8(12), pp. 1045-1052. (10.1016/S2215-0366(21)00253-4)
- Kalman, J. L. et al. 2021. Characterisation of age and polarity at onset in bipolar disorder. The British Journal of Psychiatry 219(6), pp. 659-669. (10.1192/bjp.2021.102)
- Ajnakina, O. et al. 2021. Duration of untreated psychosis in first-episode psychosis is not associated with common genetic variants for major psychiatric conditions: results from the multi-center EU-GEI study. Schizophrenia Bulletin 47(6), pp. 1653-1662. (10.1093/schbul/sbab055)
- Dimitriadis, S. I. et al. 2021. Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk. Translational Psychiatry 11, article number: 592. (10.1038/s41398-021-01678-z)
- Martin, J. et al. 2021. Sex differences in anxiety and depression in children with ADHD investigating genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(7), pp. 412-422. (10.1002/ajmg.b.32842)
- Jia, X. et al. 2021. Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder. Molecular Psychiatry 26, pp. 5239-5250. (10.1038/s41380-020-01006-9)
- Dennison, C. et al. 2021. Risk factors, clinical features, and polygenic risk scores in schizophrenia and schizoaffective disorder depressive-type. Schizophrenia Bulletin 47(5), pp. 1375-1384. (10.1093/schbul/sbab036)
- Clifton, N. E. et al. 2021. Developmental profile of psychiatric risk associated with voltage-gated cation channel activity. Biological Psychiatry 90(6) (10.1016/j.biopsych.2021.03.009)
- Rees, E. et al. 2021. Schizophrenia, autism spectrum disorders and developmental disorders share specific disruptive coding mutations. Nature Communications 12, article number: 5353. (10.1038/s41467-021-25532-4)
- Martin, J. et al. 2021. Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression. PLoS ONE 16(9), article number: e0248254. (10.1371/journal.pone.0248254)
- Riglin, L. et al. 2021. ADHD and depression: investigating a causal explanation. Psychological Medicine 51(11), pp. 1890-1897. (10.1017/S0033291720000665)
- Quattrone, D. et al. 2021. The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study. Translational Psychiatry 11(1), article number: 423. (10.1038/s41398-021-01526-0)
- Legge, S. et al. 2021. Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia. JAMA Psychiatry 78(10), pp. 1143-1151. (10.1001/jamapsychiatry.2021.1961)
- Clifton, N. E. et al. 2021. Genetic association of FMRP targets with psychiatric disorders. Molecular Psychiatry 26, pp. 2977-2990. (10.1038/s41380-020-00912-2)
- Hubbard, L. et al. 2021. Rare copy number variations are associated with poorer cognition in schizophrenia. Biological Psychiatry 90(1), pp. 28-34. (10.1016/j.biopsych.2020.11.025)
- Byrne, E. et al. 2021. Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders. Molecular Psychiatry 26, pp. 2070-2081. (10.1038/s41380-020-0705-9)
- Hall, L. S. et al. 2021. Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders. Molecular Psychiatry 26, pp. 2082-2088. (10.1038/s41380-020-0743-3)
- Amare, A. T. et al. 2021. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry 26, pp. 2457-2470. (10.1038/s41380-020-0689-5)
- Tigaret, C. M. et al. 2021. Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c. Molecular Psychiatry 26, pp. 1748-1760. (10.1038/s41380-020-01001-0)
- Mullins, N. et al. 2021. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics 53, pp. 817-829. (10.1038/s41588-021-00857-4)
- Peterson, R. E. et al. 2021. Genome-wide analyses of smoking behaviors in schizophrenia: findings from the Psychiatric Genomics Consortium. Journal of Psychiatric Research 137, pp. 215-225. (10.1016/j.jpsychires.2021.02.027)
- Riglin, L. et al. 2021. Investigating attention‐deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life?. Journal of Child Psychology and Psychiatry 62(4), pp. 449-457. (10.1111/jcpp.13297)
- Willcocks, I. et al. 2021. Clozapine metabolism is associated with absolute neutrophil count in individuals with treatment-resistant schizophrenia. Frontiers in Pharmacology 12, article number: 658734. (10.3389/fphar.2021.658734)
- Konte, B. et al. 2021. HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry. Translational Psychiatry 11, article number: 214. (10.1038/s41398-021-01322-w)
- Tripoli, G. et al. 2021. Jumping to conclusions, general intelligence, and psychosis liability: findings from the multi-centre EU-GEI case-control study. Psychological Medicine 51(4), pp. 623-633. (10.1017/S003329171900357X)
- Dennison, C. A. et al. 2021. Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank. PLoS ONE 16(3), article number: e0249189. (10.1371/journal.pone.0249189)
- Erzin, G. et al. 2021. Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. European Psychiatry 64(1), article number: e25. (10.1192/j.eurpsy.2021.19)
- Smeland, O. B. et al. 2021. Genome-wide association analysis of Parkinson's disease and schizophrenia reveals shared genetic architecture and identifies novel risk loci. Biological Psychiatry 89(3), pp. 227-235. (10.1016/j.biopsych.2020.01.026)
- Owen, M. J. and O'Donovan, M. C. 2021. Large-scale genomics: a paradigm shift in psychiatry?. Biological Psychiatry 89, pp. 5-7. (10.1016/j.biopsych.2020.01.017)
- Hannon, E. et al. 2021. DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. eLife 10, article number: e58430. (10.7554/eLife.58430)
- Chauquet, S., Zhu, Z., O'Donovan, M., Walters, J., Wray, N. and Shah, S. 2021. Investigating the potential effects of antihypertensive medication on psychiatric disorders: a mendelian randomisation study. JAMA Psychiatry 78(6), pp. 623-631. (10.1001/jamapsychiatry.2021.0005)
- Hasmi, L. et al. 2021. What makes the psychosis 'clinical high risk' state risky: psychosis itself or the co-presence of a non-psychotic disorder?. Epidemiology and Psychiatric Sciences 30, article number: e53. (10.1017/S204579602100041X)
- Pries, L. et al. 2020. Association of recent stressful life events with mental and physical health in the context of genomic and exposomic liability for schizophrenia. JAMA Psychiatry 77(12), pp. 1296-1304. (10.1001/jamapsychiatry.2020.2304)
- Ward, J. et al. 2020. The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function. Molecular Psychiatry 25, pp. 3091-3099. (10.1038/s41380-019-0439-8)
- Pries, L. et al. 2020. Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum. Epidemiology and Psychiatric Sciences 29, article number: e182. (10.1017/S2045796020000943)
- Kendall, K. M. et al. 2020. Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: a data linkage study. BJPsych Open 6(6), article number: e139. (10.1192/bjo.2020.42)
- Legge, S. E. et al. 2020. The Duffy-null genotype and risk of infection. Human Molecular Genetics 29(20), pp. 3341-3349. (10.1093/hmg/ddaa208)
- Jones, H. J. et al. 2020. A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 183(6), pp. 360-369. (10.1002/ajmg.b.32808)
- van Os, J. et al. 2020. Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study. Psychological Medicine 50(11), pp. 1884-1897. (10.1017/S003329171900196X)
- Wong, H., Wadon, M., Evans, A., Kirov, G., Modi, N., O'Donovan, M. and Thapar, A. 2020. Contribution of de novo and inherited rare copy number variants to very preterm birth. Journal of Medical Genetics 57(8), pp. 552-557. (10.1136/jmedgenet-2019-106619)
- Riglin, L. et al. 2020. Using genetics to examine a general liability to childhood psychopathology. Behavior Genetics 50, pp. 213-220. (10.1007/s10519-019-09985-4)
- Coleman, J. R. I. et al. 2020. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry 25, pp. 1430-1446. (10.1038/s41380-019-0546-6)
- Akingbuwa, W. A. et al. 2020. Genetic associations between childhood psychopathology and adult depression and associated traits in 42 998 individuals. JAMA Psychiatry 77(7), pp. 715-728. (10.1001/jamapsychiatry.2020.0527)
- Wong, H. S., Hopkins, L., O'Donovan, M. C., Thapar, A. and Modi, N. 2020. Pilot study to establish a prospective neonatal cohort: Study of Preterm Infants and Neurodevelopmental Genes (SPRING). Molecular Psychiatry 4(1), article number: e000648. (10.1136/bmjpo-2020-000648)
- Lee, S. C. et al. 2020. Area deprivation, urbanicity, severe mental illness and social drift — a population-based linkage study using routinely collected primary and secondary care data. Schizophrenia Research 220, pp. 130-140. (10.1016/j.schres.2020.03.044)
- Legge, S. et al. 2020. Clinical indicators of treatment-resistant psychosis. British Journal of Psychiatry 216(5), pp. 259-266. (10.1192/bjp.2019.120)
- Wadon, M., Modi, N., Wong, H., Thapar, A. and O'Donovan, M. 2020. Recent advances in the genetics of preterm birth. Annals of Human Genetics 84(3), pp. 205-213. (10.1111/ahg.12373)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
- Foley, C. et al. 2020. Identifying schizophrenia patients who carry pathogenic genetic copy number variants using standard clinical assessment: retrospective cohort study. British Journal of Psychiatry 216(5), pp. 275-279. (10.1192/bjp.2019.262)
- Szatkiewicz, J. P. et al. 2020. Characterization of single gene copy number variants in schizophrenia. Biological Psychiatry 87(8), pp. 736-744. (10.1016/j.biopsych.2019.09.023)
- Sullivan, S. A. et al. 2020. A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder. American Journal of Psychiatry 177(4), pp. 308-317. (10.1176/appi.ajp.2019.19060654)
- Richards, A. et al. 2020. The relationship between polygenic risk scores and cognition in schizophrenia. Schizophrenia Bulletin 46(2), pp. -. (10.1093/schbul/sbz061)
- Lewis, K. J. et al. 2020. Comparison of genetic liability for sleep traits among individuals with Bipolar Disorder I or II and control participants. JAMA Psychiatry 77(3), pp. 303-310. (10.1001/jamapsychiatry.2019.4079)
- Glanville, K. P. et al. 2020. Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated with depression. Biological Psychiatry 87(5), pp. 419-430. (10.1016/j.biopsych.2019.06.031)
- Rees, E. et al. 2020. De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia. Nature Neuroscience 23(2), pp. 179-184. (10.1038/s41593-019-0565-2)
- Hall, L. S. et al. 2020. A transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia. Human Molecular Genetics 29(1), pp. 159-167. (10.1093/hmg/ddz253)
- Legge, S. E. et al. 2019. Association of genetic liability to psychotic experiences with neuropsychotic disorders and traits. JAMA Psychiatry 76(12), pp. 1256-1265. (10.1001/jamapsychiatry.2019.2508)
- Lam, M. et al. 2019. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics 51, pp. 1670-1678. (10.1038/s41588-019-0512-x)
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Escott-Price, V. et al. 2019. Polygenic risk for schizophrenia and season of birth within the UK Biobank cohort. Psychological Medicine 49(15), pp. 2499-2504. (10.1017/S0033291718000454)
- Chapman, R. M. et al. 2019. Convergent evidence that ZNF804A is a regulator of pre-messenger RNA processing and gene expression. Schizophrenia Bulletin 45(6), pp. 1267-1278. (10.1093/schbul/sby183)
- Toste, C. et al. 2019. No effect of genome-wide significant schizophrenia risk variation at the DRD2 locus on the allelic expression of DRD2 in post-mortem striatum. Molecular Neuropsychiatry 5(4), pp. 212-217. (10.1159/000501022)
- Sykes, L. et al. 2019. Genetic variation in the psychiatric risk gene CACNA1C modulates reversal learning across species. Schizophrenia Bulletin 45(5), pp. 1024-1032. (10.1093/schbul/sby146)
- Pries, L. et al. 2019. Estimating exposome score for schizophrenia using predictive modeling approach in two independent samples: the results from the EUGEI study. Schizophrenia Bulletin 45(5), pp. 960-965. (10.1093/schbul/sbz054)
- Pain, O. et al. 2019. Novel insight into the etiology of autism spectrum disorder gained by integrating expression data with genome-wide association statistics. Biological Psychiatry 86(4), pp. 265-273. (10.1016/j.biopsych.2019.04.034)
- Mulllins, N. et al. 2019. GWAS of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores. American Journal of Psychiatry 176(8), pp. 651-660. (10.1176/appi.ajp.2019.18080957)
- Riglin, L. et al. 2019. Identifying novel types of irritability using a developmental genetic approach. American Journal of Psychiatry 176(8), pp. 635-642. (10.1176/appi.ajp.2019.18101134)
- Escott-Price, V., Pardinas, A. F., Santiago, E., Walters, J., Kirov, G., Owen, M. J. and O'Donovan, M. C. 2019. The relationship between common variant schizophrenia liability and number of offspring in the UK Biobank. American Journal of Psychiatry 176(8), pp. 661-666. (10.1176/appi.ajp.2018.18020140)
- Romagnoni, A. et al. 2019. Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data. Scientific Reports 9(1), pp. -., article number: 10351. (10.1038/s41598-019-46649-z)
- Czamara, D. et al. 2019. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications 10, article number: 2548. (10.1038/s41467-019-10461-0)
- Quattrone, D. et al. 2019. Transdiagnostic dimensions of psychopathology at first episode psychosis: findings from the multinational EU GEI study. Psychological Medicine 49(8), pp. 1378-1391. (10.1017/S0033291718002131)
- Pardinas, A. F. et al. 2019. Pharmacogenomic variants and drug interactions identified through the genetic analysis of clozapine metabolism. American Journal of Psychiatry 176(6), pp. 477-486. (10.1176/appi.ajp.2019.18050589)
- Guloksuz, S. et al. 2019. Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study. World Psychiatry 18(2), pp. 173-182. (10.1002/wps.20629)
- Stahl, E. A. et al. 2019. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics 51, pp. 793-803. (10.1038/s41588-019-0397-8)
- Kendall, K. M. et al. 2019. Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank. British Journal of Psychiatry 214(5), pp. 297-304. (10.1192/bjp.2018.301)
- Huckins, L. M. et al. 2019. Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics 51, pp. 659-674. (10.1038/s41588-019-0364-4)
- Kendall, K. M. et al. 2019. Association of rare copy number variants with risk of depression. JAMA Psychiatry 76(8), pp. 818-825. (10.1001/jamapsychiatry.2019.0566)
- Gorman, K. M. et al. 2019. Bi-allelic loss-of-function CACNA1B mutations in progressive epilepsy-dyskinesia. American Journal of Human Genetics 104(5), pp. 948-956. (10.1016/j.ajhg.2019.03.005)
- Rees, E. et al. 2019. Targeted sequencing of 10,198 samples confirms abnormalities in neuronal activity and implicates voltage-gated sodium channels in schizophrenia pathogenesis. Biological Psychiatry 85(7), pp. 554-562. (10.1016/j.biopsych.2018.08.022)
- Harold, D. et al. 2019. Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180(3), pp. 223-231. (10.1002/ajmg.b.32716)
- Lancaster, T. M. et al. 2019. Structural and functional neuroimaging of polygenic risk for schizophrenia: a recall-by-genotype-based approach. Schizophrenia Bulletin 45(2), pp. 405-414. (10.1093/schbul/sby037)
- Rice, F., Riglin, L., Thapar, A. K., Heron, J., Anney, R., O'Donovan, M. C. and Thapar, A. 2019. Characterizing developmental trajectories and the role of neuropsychiatric genetic risk variants in early-onset depression. JAMA Psychiatry 76(3), pp. 306-313. (10.1001/jamapsychiatry.2018.3338)
- Legge, S. E. et al. 2019. A genome-wide association study in individuals of African ancestry reveals the importance of the Duffy-null genotype in the assessment of clozapine-related neutropenia. Molecular Psychiatry 24, pp. 328-337. (10.1038/s41380-018-0335-7)
- Kunkle, B. W. et al. 2019. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics 51(3), pp. 414-430. (10.1038/s41588-019-0358-2)
- Richards, A. et al. 2019. Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a New Zealand longitudinal population cohort study. British Journal of Psychiatry 214(2), pp. 96-102. (10.1192/bjp.2018.227)
- Crawford, K. et al. 2019. Medical consequences of pathogenic CNVs in adults: Analysis of the UK Biobank. Journal of Medical Genetics 56, pp. 131-138. (10.1136/jmedgenet-2018-105477)
- Clifton, N. E. et al. 2019. Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry 9, article number: 74. (10.1038/s41398-019-0405-x)
- Kopczynska, M. et al. 2019. Complement system biomarkers in first episode psychosis. Schizophrenia Research 204, pp. 16-22. (10.1016/j.schres.2017.12.012)
- Escott-Price, V., Bracher-Smith, M., Menzies, G., Walters, J., Kirov, G., Owen, M. J. and O'Donovan, M. C. 2019. Genetic liability to schizophrenia is negatively associated with educational attainment in UK Biobank. Journal of Molecular Psychiatry, pp. -. (10.1038/s41380-018-0328-6)
- Vivian-Griffiths, T. et al. 2019. Predictive modeling of schizophrenia from genomic data: Comparison of polygenic risk score with kernel support vector machines approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180(1), pp. 80-85. (10.1002/ajmg.b.32705)
- Riglin, L. et al. 2019. Developmental contributions of schizophrenia risk alleles and childhood peer victimization to early-onset mental health trajectories. American Journal of Psychiatry 176(1), pp. 36-43. (10.1176/appi.ajp.2018.18010075)
- Bergen, S. E. et al. 2019. Joint contributions of rare copy number variants and common SNPs to risk for schizophrenia. American Journal of Psychiatry 176(1), pp. 29-35. (10.1176/appi.ajp.2018.17040467)
- Niarchou, M. et al. 2019. Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits. Translational Psychiatry 10, article number: 51. (10.1038/s41398-020-0688-y)
- Arnau-Soler, A. et al. 2018. Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE 13(12), article number: e0209160. (10.1371/journal.pone.0209160)
- Li, M. et al. 2018. Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science 362(6420), article number: eaat7615. (10.1126/science.aat7615)
- Owen, D. et al. 2018. Effects of pathogenic CNVs on physical traits in participants of the UK Biobank. BMC Genomics 19(1), article number: 867. (10.1186/s12864-018-5292-7)
- O'Brien, H. E. et al. 2018. Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome Biology 19, article number: 194. (10.1186/s13059-018-1567-1)
- Riglin, L. et al. 2018. The impact of schizophrenia and mood disorder risk alleles on emotional problems: investigating change from childhood to middle age. Psychological Medicine 48(13), pp. 2153-2158. (10.1017/S0033291717003634)
- Cooper, M. et al. 2018. Investigating late-onset ADHD: a population cohort investigation. Journal of Child Psychology and Psychiatry 59(10), pp. 1105-1113. (10.1111/jcpp.12911)
- Bray, N. J. and O'Donovan, M. C. 2018. The genetics of neuropsychiatric disorders. Brain and Neuroscience Advances 2, pp. 1-6. (10.1177/2398212818799271)
- Strawbridge, R. J. et al. 2018. Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry 8(1), article number: 178. (10.1038/s41398-018-0236-1)
- John, A. et al. 2018. Premature mortality among people with severe mental illness - new evidence from linked primary care data. Schizophrenia Research 199, pp. 154-162. (10.1016/j.schres.2018.04.009)
- Jones, H. J. et al. 2018. Investigating the genetic architecture of general and specific psychopathology in adolescence. Translational Psychiatry 8(1), article number: 145. (10.1038/s41398-018-0204-9)
- Fabbri, C. et al. 2018. Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies. European Neuropsychopharmacology 28(8), pp. 945-954. (10.1016/j.euroneuro.2018.05.009)
- Donohoe, G. et al. 2018. Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation. Psychological Medicine 48(10), pp. 1608-1615. (10.1017/S0033291717002987)
- Guyatt, A. L. et al. 2018. Association of copy number variation across the genome with neuropsychiatric traits in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(5), pp. 489-502. (10.1002/ajmg.b.32637)
- Skene, N. G. et al. 2018. Genetic identification of brain cell types underlying schizophrenia. Nature Genetics 50, pp. 825-833. (10.1038/s41588-018-0129-5)
- Baker, E., Schmidt, K. M., Sims, R., O'Donovan, M. C., Williams, J., Holmans, P. and Escott-Price, V. 2018. POLARIS: polygenic LD-adjusted risk score approach for set-based analysis of GWAS data. Genetic Epidemiology 42(4), pp. 366-377. (10.1002/gepi.22117)
- Martin, J. et al. 2018. A genetic investigation of sex bias in the prevalence of attention-deficit/hyperactivity disorder. Biological Psychiatry 83(12), pp. 1044-1053. (10.1016/j.biopsych.2017.11.026)
- Ruderfer, D. M. et al. 2018. Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. Cell 173(7), pp. 1705-1715.e16. (10.1016/j.cell.2018.05.046)
- Leonenko, G. et al. 2018. A data-driven investigation of relationships between bipolar psychotic symptoms and schizophrenia genome-wide significant genetic loci. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(4), pp. 468-475. (10.1002/ajmg.b.32635)
- Wray, N. R. et al. 2018. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics 50(5), pp. 668-681. (10.1038/s41588-018-0090-3)
- Gusev, A. et al. 2018. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nature Genetics 50, pp. 538-548. (10.1038/s41588-018-0092-1)
- Cosgrove, D. et al. 2018. Effects of MiR-137 genetic risk score on brain volume and cortical measures in patients with schizophrenia and controls. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(3), pp. 369-376. (10.1002/ajmg.b.32620)
- Pardinas, A. F. et al. 2018. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics 50, pp. 381-389. (10.1038/s41588-018-0059-2)
- Strawbridge, R. J. et al. 2018. Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry 8, article number: 39. (10.1038/s41398-017-0079-1)
- Allardyce, J. et al. 2018. Association between schizophrenia-related polygenic liability and the occurrence and level of mood-incongruent psychotic symptoms in bipolar disorder. JAMA Psychiatry 75(1), pp. 28-35. (10.1001/jamapsychiatry.2017.3485)
- Green, E. K. et al. 2017. Genome-wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar type. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(8), pp. 767-771. (10.1002/ajmg.b.32572)
- Cosgrove, D. et al. 2017. Cognitive characterization of schizophrenia risk variants involved in synaptic transmission: evidence of CACNA1C's role in working memory. Neuropsychopharmacology 42, pp. 2612-2622. (10.1038/npp.2017.123)
- Ward, J. et al. 2017. Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with MDD, anxiety disorder and schizophrenia. Translational Psychiatry 7, article number: 1264. (10.1038/s41398-017-0012-7)
- Li, Z. et al. 2017. Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nature Genetics 49, pp. 1576-1583. (10.1038/ng.3973)
- Leonenko, G. et al. 2017. Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(7), pp. 724-731. (10.1002/ajmg.b.32560)
- Legge, S. E. et al. 2017. Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia. Molecular Psychiatry 22, pp. 1502-1508. (10.1038/mp.2016.97)
- Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
- Sims, R. et al. 2017. Rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics 49, pp. 1373-1384. (10.1038/ng.3916)
- Direk, N. et al. 2017. An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype. Biological Psychiatry 82(5), pp. 322-329. (10.1016/j.biopsych.2016.11.013)
- Leonenko, G. et al. 2017. Investigation of relationships between bipolar disorder phenotypes and genome-wide significant loci from PGC2 schizophrenia. European Neuropsychopharmacology 27(S3), pp. S383-S384. (10.1016/j.euroneuro.2016.09.416)
- Singh, T. et al. 2017. The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability. Nature Genetics 49, pp. 1167-1173. (10.1038/ng.3903)
- Kendall, K. M. et al. 2017. Cognitive performance among carriers of pathogenic copy number variants: analysis of 152,000 UK Biobank subjects. Biological Psychiatry 82(2), pp. P103-110. (10.1016/j.biopsych.2016.08.014)
- Hendricks, A. E. et al. 2017. Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity. Scientific Reports 7, article number: 4394. (10.1038/s41598-017-03054-8)
- Witt, S. H. et al. 2017. Genome-wide association study of borderline personality disorder reveals genetic overlap with the bipolar disorder, schizophrenia and major depression. Translational Psychiatry 7, article number: e1155.
- Hannon, E., Weedon, M., Bray, N., O'Donovan, M. and Mill, J. 2017. Pleiotropic effects of trait-associated genetic variation on DNA methylation: utility for refining GWAS loci. American Journal of Human Genetics 100(6), pp. 954-959. (10.1016/j.ajhg.2017.04.013)
- García-González, J. et al. 2017. Pharmacogenetics of antidepressant response: a polygenic approach. Progress in Neuro-Psychopharmacology and Biological Psychiatry 75, pp. 128-134. (10.1016/j.pnpbp.2017.01.011)
- McLaughlin, R. L. et al. 2017. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications 8, article number: 14774. (10.1038/ncomms14774)
- Riglin, L., Collishaw, S., Richards, A., Thapar, A., Maughan, B., O'Donovan, M. C. and Thapar, A. 2017. Schizophrenia polygenic risk score and psychotic risk detection - authors' reply. The Lancet Psychiatry 4(3), pp. 188-189. (10.1016/S2215-0366(17)30052-4)
- Clifton, N. E. et al. 2017. Schizophrenia copy number variants and associative learning. Molecular Psychiatry 22(2), pp. 178-182. (10.1038/mp.2016.227)
- Marshall, C. R. et al. 2017. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics 49, pp. 27-35. (10.1038/ng.3725)
- Lo, M. et al. 2017. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics 49, pp. 152-156. (10.1038/ng.3736)
- Cosgrove, D. et al. 2017. MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls. Translational Psychiatry 7(1), pp. e1012. (10.1038/tp.2016.286)
- Giegling, I. et al. 2017. Genetics of schizophrenia: A consensus paper of the WFSBP task force on genetics. World Journal of Biological Psychiatry 18(7), pp. 492-505. (10.1080/15622975.2016.1268715)
- Fabbri, C. et al. 2017. Consensus paper of the WFSBP Task Force on Genetics: genetics, epigenetics and gene expression markers of major depressive disorder and antidepressant response. World Journal of Biological Psychiatry 18(1), pp. 5-28. (10.1080/15622975.2016.1208843)
- Fraguas, D., Díaz-Caneja, C. M., State, M. W., O'Donovan, M. C., Gur, R. E. and Arango, C. 2017. Mental disorders of known aetiology and precision medicine in psychiatry: a promising but neglected alliance [Editorial]. Psychological Medicine 47(2), pp. 193-197. (10.1017/S0033291716001355)
- Riglin, L., Collishaw, S., Richards, A., Thapar, A. K., Maughan, B., O'Donovan, M. C. and Thapar, A. 2017. Schizophrenia risk alleles and neurodevelopmental outcomes in childhood: a population-based cohort study. Lancet Psychiatry 4(1), pp. 57-62. (10.1016/S2215-0366(16)30406-0)
- Sullivan, P. F. et al. 2017. Psychiatric genomics: an update and an agenda. American Journal of Psychiatry 175(1), pp. 15-27. (10.1176/appi.ajp.2017.17030283)
- Riglin, L. et al. 2016. Association of genetic risk variants with attention-deficit/hyperactivity disorder trajectories in the general population. JAMA Psychiatry 73(12), pp. 1285-1292. (10.1001/jamapsychiatry.2016.2817)
- Whitton, L. et al. 2016. Cognitive analysis of schizophrenia risk genes that function as epigenetic regulators of gene expression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(8), pp. 1170-1179. (10.1002/ajmg.b.32503)
- Rees, E. et al. 2016. Analysis of intellectual disability copy number variants for association with schizophrenia. JAMA Psychiatry 73(9), pp. 963-969. (10.1001/jamapsychiatry.2016.1831)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Tansey, K. E. et al. 2016. Common alleles contribute to schizophrenia in CNV carriers. Molecular Psychiatry 21, pp. 1085-1089. (10.1038/mp.2015.143)
- Smith, D. J. et al. 2016. Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci. Molecular Psychiatry 21, pp. 749-757. (10.1038/mp.2016.49)
- Martin, J. et al. 2016. Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study. American Journal of Epidemiology 183(12), pp. 1149-1158. (10.1093/aje/kww009)
- Legge, S. et al. 2016. Reasons for discontinuing clozapine: a cohort study of patients commencing treatment. Schizophrenia Research 174, pp. 113-119. (10.1016/j.schres.2016.05.002)
- Han, J. et al. 2016. Gender differences in CNV burden do not confound schizophrenia CNV associations. Scientific Reports 6, article number: 25986. (10.1038/srep25986)
- Isles, A. R. et al. 2016. Parental origin of interstitial duplications at 15q11.2-q13.3 in schizophrenia and neurodevelopmental disorders. PLoS Genetics 12(5), article number: e1005993. (10.1371/journal.pgen.1005993)
- Singh, T. et al. 2016. Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders. Nature Neuroscience 19(4), pp. 571-577. (10.1038/nn.4267)
- van Goozen, S. H. M. et al. 2016. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. Journal of Child Psychology and Psychiatry 57(4), pp. 472-480. (10.1111/jcpp.12464)
- Lawrie, S. M., O'Donovan, M. C., Saks, E., Burns, T. and Lieberman, J. A. 2016. Towards diagnostic markers for the psychoses. The Lancet Psychiatry 3(4), pp. 375-385. (10.1016/S2215-0366(16)00021-3)
- Lawrie, S. M., O'Donovan, M. C., Saks, E., Burns, T. and Lieberman, J. A. 2016. Improving classification of psychoses. The Lancet Psychiatry 3(4), pp. 367-374. (10.1016/S2215-0366(15)00577-5)
- Carroll, L. S. et al. 2016. Mutation screening of SCN2A in schizophrenia and identification of a novel loss-of-function mutation. Psychiatric Genetics 26(2), pp. 60-65. (10.1097/YPG.0000000000000110)
- Franke, B. et al. 2016. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience 19(3), pp. 420-431. (10.1038/nn.4228)
- Singh, T. et al. 2016. Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders. Nature Neuroscience 19, pp. 571-577. (10.1101/036384)
- Jones, H. J. et al. 2016. Phenotypic manifestation of genetic risk for schizophrenia during adolescence in the general population. JAMA Psychiatry 73(3), pp. 221-228. (10.1001/jamapsychiatry.2015.3058)
- Richards, A. et al. 2016. Exome arrays capture polygenic rare variant contributions to schizophrenia. Human Molecular Genetics 25(5), pp. 1001-1007. (10.1093/hmg/ddv620)
- Bigdeli, T. B. et al. 2016. Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(2), pp. 276-289. (10.1002/ajmg.b.32402)
- Holland, D. et al. 2016. Estimating effect sizes and expected replication probabilities from GWAS summary statistics. Frontiers in Genetics 7, article number: 15. (10.3389/fgene.2016.00015)
- Lancaster, T. et al. 2016. Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals. Human Brain Mapping 37(2), pp. 491-500. (10.1002/hbm.23044)
- Hannon, E. et al. 2016. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nature Neuroscience 19(1), pp. 48-54. (10.1038/nn.4182)
- Jun, G. et al. 2016. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry 21, pp. 108-117. (10.1038/mp.2015.23)
- Wang, Y. et al. 2016. Leveraging genomic annotations and pleiotropic enrichment for improved replication rates in schizophrenia GWAS. PLoS Genetics 12(1), article number: e1005803. (10.1371/journal.pgen.1005803)
- Hubbard, L. et al. 2016. Evidence of common genetic overlap between schizophrenia and cognition. Schizophrenia Bulletin 42(3), pp. 832-842. (10.1093/schbul/sbv168)
- Pers, T. H., Timshel, P., Ripke, S., Sullivan, P. F., O'Donovan, M. C., Franke, L. and Hirschhorn, J. N. 2016. Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes. Human Molecular Genetics 25(6), pp. 1247-1254. (10.1093/hmg/ddw007)
- Corvin, A. and O'Donovan, M. C. 2016. Psychiatric genetics: what's new in 2015?. The Lancet Psychiatry 3(1), pp. 10-12. (10.1016/S2215-0366(15)00571-4)
- O'Donovan, M. C. and Owen, M. J. 2016. The implications of the shared genetics of psychiatric disorders. Nature Medicine 22, pp. 1214-1219. (10.1038/nm.4196)
- Loh, P. et al. 2015. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nature Genetics 47, pp. 1385-1392. (10.1038/ng.3431)
- Tansey, K. E. et al. 2015. Common alleles contribute to schizophrenia in CNV carriers [Erratum]. Molecular Psychiatry 21, article number: 1153. (10.1038/mp.2015.170)
- Escott-Price, V., Kirov, G., Rees, E., Isles, A. R., Owen, M. J. and O'Donovan, M. C. 2015. No evidence for enrichment in schizophrenia for common allelic associations at imprinted loci. PLoS ONE 10(12), pp. -., article number: e0144172. (10.1371/journal.pone.0144172)
- Andreassen, O. A. et al. 2015. Correction: Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate. PLoS Genetics 11(11), article number: e1005544. (10.1371/journal.pgen.1005544)
- Ingason, A. et al. 2015. Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case?control sample of schizophrenia. Translational Psychiatry 5(10), article number: e656. (10.1038/tp.2015.151)
- Walter, K. et al. 2015. The UK10K project identifies rare variants in health and disease. Nature 526, pp. 82-90. (10.1038/nature14962)
- Lee, S. H. et al. 2015. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology 44(5), pp. 1706-1721. (10.1093/ije/dyv136)
- O'Donovan, M. C. 2015. What have we learned from the Psychiatric Genomics Consortium. World Psychiatry 14(3), pp. 291-293. (10.1002/wps.20270)
- Vilhjálmsson, B. et al. 2015. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. American Journal of Human Genetics 97(4), pp. 576-592. (10.1016/j.ajhg.2015.09.001)
- Huang, J. et al. 2015. Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel. Nature Communications 6, article number: 8111. (10.1038/ncomms9111)
- O'Donovan, M. C. 2015. Novel genetic advances in schizophrenia: an interview with Michael O'Donovan. BMC Medicine 13, article number: 181. (10.1186/s12916-015-0417-1)
- Jones, L. et al. 2015. Convergent genetic and expression data implicate immunity in Alzheimer's disease. Alzheimer's and Dementia 11(6), pp. 658-671. (10.1016/j.jalz.2014.05.1757)
- Østergaard, S. D. et al. 2015. Associations between potentially modifiable risk factors and Alzheimer disease: A mendelian randomization study. PLOS MEDICINE 12(6), pp. e1001841., article number: e1001841. (10.1371/journal.pmed.1001841)
- Desikan, R. S. et al. 2015. Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer Disease. Circulation 131(23), pp. 2061-2069. (10.1161/CIRCULATIONAHA.115.015489)
- Schmidts, M. et al. 2015. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications 6, article number: 7074. (10.1038/ncomms8074)
- Pocklington, A. et al. 2015. Novel findings from CNVs implicate inhibitory and excitatory signaling complexes in schizophrenia. Neuron 86(5), pp. 1203-1214. (10.1016/j.neuron.2015.04.022)
- Arloth, J. et al. 2015. Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders. Neuron 86(5), pp. 1189-1202. (10.1016/j.neuron.2015.05.034)
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 56(6), pp. 648-656. (10.1111/jcpp.12336)
- Hosp, F. et al. 2015. Quantitative interaction proteomics of neurodegenerative disease proteins. Cell Reports 11(7), pp. 1134-46. (10.1016/j.celrep.2015.04.030)
- Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
- Rees, E., O'Donovan, M. C. and Owen, M. J. 2015. Genetics of schizophrenia. Current Opinion in Behavioral Sciences 2, pp. 8-14. (10.1016/j.cobeha.2014.07.001)
- Spiers, H. et al. 2015. Methylomic trajectories across human fetal brain development. Genome Research 25(3), pp. 338-352. (10.1101/gr.180273.114)
- Bulik-Sullivan, B. K. et al. 2015. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nature Genetics 47(3), pp. 291-295. (10.1038/ng.3211)
- Oertel-Knöchel, V. et al. 2015. Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: Evidence from two independent cohorts. NeuroImage: Clinical 7, pp. 764-770. (10.1016/j.nicl.2015.03.005)
- Vivian-Griffiths, T. et al. 2015. Utilising machine-learning algorithms to uncover complex genetic interactions in schizophrenia [Conference Abstract]. Human Heredity 79(1), pp. 48-48., article number: A46. (10.1159/000381109)
- Farrell, M. S. et al. 2015. Evaluating historical candidate genes for schizophrenia. Molecular Psychiatry 20(5), pp. 555-562. (10.1038/mp.2015.16)
- Taylor, P. N. et al. 2015. Whole-genome sequence-based analysis of thyroid function. Nature Communications 6, article number: 5681. (10.1038/ncomms6681)
- O'Dushlaine, C. et al. 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 18(2), pp. 199-209. (10.1038/nn.3922)
- Desikan, R. S. et al. 2015. Genetic overlap between Alzheimer's Disease and Parkinson's Disease at the MAPT locus. Molecular Psychiatry 20(12), pp. 1588-1595. (10.1038/mp.2015.6)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
- Maier, R. et al. 2015. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. American Journal of Human Genetics 96(2), pp. 283-294. (10.1016/j.ajhg.2014.12.006)
- Kavanagh, D., Tansey, K., O'Donovan, M. C. and Owen, M. J. 2015. Schizophrenia genetics: emerging themes for a complex disorder. Molecular Psychiatry 20(1), pp. 72-76. (10.1038/mp.2014.148)
- Green, E. K. et al. 2015. Copy number variation in bipolar disorder. Molecular Psychiatry 21(1), pp. 89-93. (10.1038/mp.2014.174)
- Hall, J., Trent, S., Thomas, K. L., O'Donovan, M. C. and Owen, M. J. 2015. Genetic risk for schizophrenia: convergence on synaptic pathways Involved in plasticity. Biological Psychiatry 77(1), pp. 52-68. (10.1016/j.biopsych.2014.07.011)
- Tansey, K. E., Owen, M. J. and O'Donovan, M. C. 2015. Schizophrenia genetics: Building the foundations of the future. Schizophrenia Bulletin 41(1), pp. 15-19. (10.1093/schbul/sbu162)
- Rees, E. et al. 2015. Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia. Translational Psychiatry 5(7), article number: e607. (10.1038/tp.2015.99)
- Georgieva, L. et al. 2014. De novo CNVs in bipolar affective disorder and schizophrenia. Human Molecular Genetics 23(24), pp. 6677-6683. (10.1093/hmg/ddu379)
- Kendler, K. S. and O'Donovan, M. C. 2014. A breakthrough in schizophrenia genetics. JAMA Psychiatry 71(12), pp. 1319-1320. (10.1001/jamapsychiatry.2014.1776)
- De Rubeis, S. et al. 2014. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515, pp. 209-215. (10.1038/nature13772)
- Gusev, A. et al. 2014. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. American Journal of Human Genetics 95(5), pp. 535-552. (10.1016/j.ajhg.2014.10.004)
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2014. Genetic risk for Attention Deficit/Hyperactivity Disorder contributes to neurodevelopmental traits in the general population. Biological Psychiatry 76(8), pp. 664-671. (10.1016/j.biopsych.2014.02.013)
- Ruderfer, D. M. et al. 2014. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Molecular Psychiatry 19(9), pp. 1017-1024. (10.1038/mp.2013.138)
- Timpson, N. J. et al. 2014. A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans. Nature Communications 5, article number: 4871. (10.1038/ncomms5871)
- Robinson, E. B. et al. 2014. Response to 'Predicting the diagnosis of autism spectrum disorder using gene pathway analysis'. Molecular Psychiatry 19(8), pp. 860-1. (10.1038/mp.2013.125)
- Crawford, A. A. et al. 2014. Adverse effects from antidepressant treatment: randomised controlled trial of 601 depressed individuals. Psychopharmacology 231(15), pp. 2921-2931. (10.1007/s00213-014-3467-8)
- Tansey, K. et al. 2014. Copy number variants and therapeutic response to antidepressant medication in major depressive disorder. The Pharmacogenomics Journal 14(4), pp. 395-399. (10.1038/tpj.2013.51)
- Szatkiewicz, J. P. et al. 2014. Copy number variation in schizophrenia in Sweden. Molecular Psychiatry 19(7), pp. 762-773. (10.1038/mp.2014.40)
- Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53(7), pp. 761-770.e26. (10.1016/j.jaac.2014.03.004)
- Craddock, N. J. et al. 2014. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophrenia Bulletin 40(4), pp. 729-736. (10.1093/schbul/sbu069)
- Morris, D. W. et al. 2014. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Human Molecular Genetics 23(12), pp. 3316-3326. (10.1093/hmg/ddu025)
- Escott-Price, V. et al. 2014. Gene-wide analysis detects two new susceptibility genes for Alzheimer's Disease. PLoS ONE 9(6), article number: e94661. (10.1371/journal.pone.0094661)
- Liu, G. et al. 2014. Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies. Neurobiology of Aging 35(4), pp. 786-92. (10.1016/j.neurobiolaging.2013.10.084)
- Pocklington, A., O'Donovan, M. C. and Owen, M. J. 2014. The synapse in schizophrenia. European Journal of Neuroscience 39(7), pp. 1059-1067. (10.1111/ejn.12489)
- Rees, E. et al. 2014. CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. Human Molecular Genetics 23(6), pp. 1669-1676. (10.1093/hmg/ddt540)
- Mulle, J. G. et al. 2014. Reciprocal duplication of the Williams-Beuren Syndrome deletion on chromosome 7q11.23 is associated with schizophrenia. Biological Psychiatry 75(5), pp. 371-7. (10.1016/j.biopsych.2013.05.040)
- Rees, E. et al. 2014. Analysis of copy number variations at 15 schizophrenia-associated loci. British Journal of Psychiatry 204(2), pp. 108-114. (10.1192/bjp.bp.113.131052)
- Fromer, M. et al. 2014. De novo mutations in schizophrenia implicate synaptic networks. Nature 506, pp. 179-184. (10.1038/nature12929)
- Steinberg, S. et al. 2014. Common variant at 16p11.2 conferring risk of psychosis. Molecular Psychiatry 19(1), pp. 108-114. (10.1038/mp.2012.157)
- Andreassen, O. A. et al. 2014. Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Molecular Psychiatry 20(2), pp. 207. (10.1038/mp.2013.195)
- Tansey, K. et al. 2014. Genetic susceptibility for bipolar disorder and response to antidepressants in major depressive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 165(1), pp. 77-83. (10.1002/ajmg.b.32210)
- Martin, J., Hamshere, M. L., O'Donovan, M. C., Rutter, M. and Thapar, A. 2014. Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders 44(1), pp. 204-215. (10.1007/s10803-013-1865-0)
- Hodgson, K. et al. 2014. Genetic predictors of antidepressant side effects: A grouped candidate gene approach in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study. Journal of Psychopharmacology 28(2), pp. 142-150. (10.1177/0269881113517957)
- Bacanu, S. et al. 2014. Functional SNPs are enriched for schizophrenia association signals [Letter]. Molecular Psychiatry 19(3), pp. 276-277. (10.1038/mp.2013.33)
- Green, E. K. et al. 2013. Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. Molecular Psychiatry 18(12), pp. 1302-1307. (10.1038/mp.2012.142)
- van Scheltinga, A. F. T. et al. 2013. Schizophrenia genetic variants are not associated with intelligence. Psychological Medicine 43(12), pp. 2563-2570. (10.1017/S0033291713000196)
- Grozeva, D. et al. 2013. Reduced burden of very large and rare CNVs in bipolar affective disorder. Bipolar Disorders 15(8), pp. 893-8. (10.1111/bdi.12125)
- Lambert, J. et al. 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease [Letter]. Nature Genetics 45(12), pp. 1452-1458. (10.1038/ng.2802)
- Rees, E. et al. 2013. Evidence that duplications of 22q11.2 protect against schizophrenia. Molecular Psychiatry n/a (10.1038/mp.2013.156)
- Zammit, S. et al. 2013. A population-based study of genetic variation and psychotic experiences in adolescents. Schizophrenia Bulletin 40(6), pp. 1254-1262. (10.1093/schbul/sbt146)
- de Candia, T. et al. 2013. Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. American Journal of Human Genetics 93(3), pp. 463-470. (10.1016/j.ajhg.2013.07.007)
- Ruderfer, D. et al. 2013. Mosaic copy number variation in schizophrenia. European Journal of Human Genetics 21(9), pp. 1007-1011. (10.1038/ejhg.2012.287)
- Lee, S. et al. 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45(9), pp. 984-994. (10.1038/ng.2711)
- Ripke, S. et al. 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics 45(10), pp. 1150-1159. (10.1038/ng.2742)
- Walters, J. T. R. et al. 2013. The role of the major histocompatibility complex region in cognition and brain structure: a schizophrenia GWAS follow-up. American Journal of Psychiatry 170(8), pp. 877-885. (10.1176/appi.ajp.2013.12020226)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
- Majounie, E. et al. 2013. Variation in tau isoform expression in different brain regions and disease states. Neurobiology of Aging 34(7), pp. 1922.e7-1922.e12. (10.1016/j.neurobiolaging.2013.01.017)
- Yang, L. et al. 2013. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162(5), pp. 419-430. (10.1002/ajmg.b.32169)
- Hamshere, M. L. et al. 2013. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Molecular Psychiatry 18(6), pp. 708-712. (10.1038/mp.2012.67)
- Landerl, K. et al. 2013. Predictors of developmental dyslexia in European orthographies with varying complexity. Journal of Child Psychology and Psychiatry 54(6), pp. 686-694. (10.1111/jcpp.12029)
- Zou, F. et al. 2013. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's Disease pathology. PLoS ONE 8(5), article number: e64802. (10.1371/journal.pone.0064802)
- Kavanagh, D., Dwyer, S., O'Donovan, M. C. and Owen, M. J. 2013. The ENCODE project: implications for psychiatric genetics. Molecular Psychiatry 18(5), pp. 540-542. (10.1038/mp.2013.13)
- Smoller, J. W. et al. 2013. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. The Lancet 381(9875), pp. 1371-1379. (10.1016/S0140-6736(12)62129-1)
- Lambert, J. C. et al. 2013. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease [Correction]. Molecular Psychiatry 18(4), pp. 521. (10.1038/mp.2012.75)
- Kronenberg, F. et al. 2013. Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease [Article]. PLoS ONE 8(4), pp. e59905. (10.1371/journal.pone.0059905)
- Ripke, S. et al. 2013. A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry 18(4), pp. 497-511. (10.1038/mp.2012.21)
- Gibson, G. et al. 2013. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genetics 9(4), article number: e1003449. (10.1371/journal.pgen.1003449)
- Terwisscha van Scheltinga, A. F. et al. 2013. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry 73(6), pp. 525-531. (10.1016/j.biopsych.2012.08.017)
- Guha, S. et al. 2013. Implication of a rare deletion at distal 16p11.2 in schizophrenia. JAMA Psychiatry 70(3), pp. 253-260. (10.1001/2013.jamapsychiatry.71)
- Williams, H. J., Monks, S., Murphy, K. C., Kirov, G., O'Donovan, M. C. and Owen, M. J. 2013. Schizophrenia two-hit hypothesis in velo-cardio facial syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162(2), pp. 177-182. (10.1002/ajmg.b.32129)
- Donohoe, G. et al. 2013. Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253. Genes, Brain and Behavior 12(2), pp. 203-209. (10.1111/gbb.12016)
- Chapman, J. et al. 2013. A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk. Human Molecular Genetics 22(4), pp. 816-824. (10.1093/hmg/dds476)
- Andreassen, O. et al. 2013. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. American Journal of Human Genetics 92(2), pp. 197-209. (10.1016/j.ajhg.2013.01.001)
- Kim, Y. et al. 2013. Non-random mating, parent-of-origin, and maternal-fetal incompatibility effects in schizophrenia. Schizophrenia Research 143(1), pp. 11-17. (10.1016/j.schres.2012.11.002)
- Visscher, P. M. et al. 2013. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS Genetics 9(4), pp. e1003455. (10.1371/journal.pgen.1003455)
- Chapuis, J. et al. 2013. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology [Article]. Molecular Psychiatry 18(11), pp. 1225-1234. (10.1038/mp.2013.1)
- Green, E. K. et al. 2013. Association at SYNE1 in both bipolar disorder and recurrent major depression. Molecular Psychiatry 18, pp. 614-617. (10.1038/mp.2012.48)
- Prata, D. P. et al. 2013. Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity. Human Brain Mapping 34(9), pp. 2025-2031. (10.1002/hbm.22045)
- Kirov, G. et al. 2013. The penetrance of copy number variations for schizophrenia and developmental delay. Biological Psychiatry 75(5), pp. 378-385. (10.1016/j.biopsych.2013.07.022)
- Aberg, K. A. et al. 2013. A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry 70(6), pp. 573-581. (10.1001/jamapsychiatry.2013.288)
- Hollingworth, P. et al. 2012. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Molecular Psychiatry 17(12), pp. 1316-1327. (10.1038/mp.2011.125)
- Eyre, S. et al. 2012. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics 44(12), pp. 1336-1340. (10.1038/ng.2462)
- Cooper, J. D. et al. 2012. Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics 21(23), pp. 5202-5208. (10.1093/hmg/dds357)
- Jostins, L. et al. 2012. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491(7422), pp. 119-124. (10.1038/nature11582)
- Williams, H. J., Georgieva, L., Dwyer, S. L., Kirov, G., Owen, M. J. and O'Donovan, M. C. 2012. Absence of de novo point mutations in exons of GRIN2B in a large schizophrenia trio sample [Letter]. Schizophrenia Research 141(2-3), pp. 274-276. (10.1016/j.schres.2012.08.024)
- O'Donovan, M. C., Owen, M. J., Walters, J. T. R., Irish Schizophrenia Genomics Consortium, . and Wellcome Trust Case Control Consortium 2, . 2012. Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia. Biological psychiatry 72(8), pp. 620-628. (10.1016/j.biopsych.2012.05.035)
- Fromer, M. et al. 2012. Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth. American Journal of Human Genetics 91(4), pp. 597-607. (10.1016/j.ajhg.2012.08.005)
- Tansey, K. E. et al. 2012. Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis. Plos Medicine 9(10), article number: e1001326. (10.1371/journal.pmed.1001326)
- Levinson, D. F. et al. 2012. Genome-wide association study of multiplex schizophrenia pedigrees. American Journal of Psychiatry 169(9), pp. 963-973. (10.1176/appi.ajp.2012.11091423)
- Hamilton, G. et al. 2012. The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B(6), pp. 696-709. (10.1002/ajmg.b.32073)
- Ayalew, M. et al. 2012. Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Molecular Psychiatry 17(9), pp. 887-905. (10.1038/mp.2012.37)
- Shi, H. et al. 2012. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging 33(8), article number: 1849.e5. (10.1016/j.neurobiolaging.2012.02.014)
- Hamilton, G. et al. 2012. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiology of Aging 33(8), article number: 1848.e1. (10.1016/j.neurobiolaging.2012.02.005)
- Escott-Price, V., Schmidt, K. M., Vedernikov, A., Owen, M. J., Craddock, N. J., Holmans, P. A. and O'Donovan, M. C. 2012. Permutation-based approaches do not adequately allow for linkage disequilibrium in gene-wide multi-locus association analysis. European Journal of Human Genetics 20(8), pp. 890-896. (10.1038/ejhg.2012.8)
- Sullivan, P. F., Daly, M. J. and O'Donovan, M. C. 2012. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nature Reviews Genetics 13(8), pp. 537-551. (10.1038/nrg3240)
- Jia, P. et al. 2012. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Computational Biology 8(7), article number: e1002587. (10.1371/journal.pcbi.1002587)
- Derks, E. M. et al. 2012. Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis. PLoS ONE 7(6), article number: e37852. (10.1371/journal.pone.0037852)
- Rees, E., Kirov, G., O'Donovan, M. C. and Owen, M. J. 2012. De Novo mutation in schizophrenia. Schizophrenia Bulletin 38(3), pp. 377-381. (10.1093/schbul/sbs047)
- Hudson, G. et al. 2012. No consistent evidence for association between mtDNA variants and Alzheimer disease. Neurology 78(14), pp. 1038-1042. (10.1212/WNL.0b013e31824e8f1d)
- Keller, M. C. et al. 2012. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. Plos Genetics 8(4), article number: e1002656. (10.1371/journal.pgen.1002656)
- Håvik, B. et al. 2012. DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. PLoS ONE 7(4), pp. e35424. (10.1371/journal.pone.0035424)
- Grozeva, D. et al. 2012. Independent estimation of the frequency of rare CNVs in the UK population confirms their role in schizophrenia. Schizophrenia Research 135(1-3), pp. 1-7. (10.1016/j.schres.2011.11.004)
- Lambert, J. C. et al. 2012. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. Molecular Psychiatry 18, pp. 461-470. (10.1038/mp.2012.14)
- Collins, A. L., Kim, Y., Sklar, P., O'Donovan, M. C. and Sullivan, P. F. 2012. Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. Psychological Medicine 42(3), pp. 607-616. (10.1017/S0033291711001607)
- Kirov, G. et al. 2012. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Molecular Psychiatry 17(2), pp. 142-153. (10.1038/mp.2011.154)
- Jia, P. et al. 2012. A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. Journal of Medical Genetics 49(2), pp. 96-103. (10.1136/jmedgenet-2011-100397)
- Richards, A. et al. 2012. Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Molecular Psychiatry 17(2), pp. 193-201. (10.1038/mp.2011.11)
- Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
- Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169(2), pp. 195-204. (10.1176/appi.ajp.2011.11060822)
- Gerrish, A. et al. 2012. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's Disease. Journal of Alzheimer's Disease 28(2), pp. 377-387. (10.3233/JAD-2011-110824)
- Sullivan, P., Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2012. Don't give up on GWAS [Letter]. Molecular Psychiatry 17(1), pp. 2-3. (10.1038/mp.2011.94)
- Chapman, R. M., Tinsley, C. L., Doyle, A. M., O'Donovan, M. C. and Blake, D. J. 2012. Inducible over-expression and siRNA mediated knock-down of the schizophrenia susceptibility gene ZNF804A: Detection of altered gene expression and splicing using whole genome exon arrays. International Journal of Developmental Neuroscience 30(8), pp. 673-673. (10.1016/j.ijdevneu.2012.10.011)
- Doherty, J. L., O'Donovan, M. C. and Owen, M. J. 2012. Recent genomic advances in schizophrenia. Clinical Genetics 81(2), pp. 103-109. (10.1111/j.1399-0004.2011.01773.x)
- Hinney, A. et al. 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 888-897. (10.1002/ajmg.b.31246)
- Cardno, A. G. et al. 2011. A genomewide linkage study of age at onset in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(8), pp. 929-940. (10.1002/ajmg.1404)
- Rees, E., Escott-Price, V., Owen, M. J., O'Donovan, M. C. and Kirov, G. 2011. De novo rates and selection of schizophrenia-associated copy number variants. Biological Psychiatry 70(12), pp. 1109-1114. (10.1016/j.biopsych.2011.07.011)
- Tognin, S., Viding, E., McCrory, E. J., Taylor, L., O'Donovan, M. C., McGuire, P. and Mechelli, A. 2011. Effects of DTNBP1 genotype on brain development in children. Journal of Child Psychology and Psychiatry 52(12), pp. 1287-1294. (10.1111/j.1469-7610.2011.02427.x)
- Sklar, P. et al. 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 [Letter]. Nature Genetics 43(10), pp. 977-983. (10.1038/ng.943)
- Ripke, S. et al. 2011. Genome-wide association study identifies five new schizophrenia loci [Letter]. Nature Genetics 43(10), pp. 969-976. (10.1038/ng.940)
- Chen, J. et al. 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131(1-3), pp. 43-51.
- Escott-Price, V. et al. 2011. An examination of single nucleotide polymorphism selection prioritization strategies for tests of gene-gene interaction. Biological Psychiatry 70(2), pp. 198-203. (10.1016/j.biopsych.2011.01.034)
- Chen, J. et al. 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131(1-3), pp. 43-51. (10.1016/j.schres.2011.06.023)
- Lewis, G. et al. 2011. Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial. British Journal of Psychiatry 198(6), pp. 464-471. (10.1192/bjp.bp.110.082727)
- Hollingworth, P. et al. 2011. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics 43(5), pp. 429-435. (10.1038/ng.803)
- Williams, H. J. et al. 2011. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Molecular Psychiatry 16(4), pp. 429-441. (10.1038/mp.2010.36)
- Stergiakouli, E. et al. 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10(3), pp. 334-344. (10.1111/j.1601-183x.2010.00672.x)
- Ingason, A. et al. 2011. Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness. American Journal of Psychiatry 168(4), pp. 408-417. (10.1176/appi.ajp.2010.09111660)
- Ikeda, M. et al. 2011. Genome-Wide Association Study of Schizophrenia in a Japanese Population. Biological Psychiatry 69(5), pp. 472-478. (10.1016/j.biopsych.2010.07.010)
- O'Dushlaine, C. et al. 2011. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Molecular Psychiatry 16(3), pp. 286-292. (10.1038/mp.2010.7)
- Zuliani, R. et al. 2011. Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry Research: Neuroimaging 191(2), pp. 133-137. (10.1016/j.pscychresns.2010.11.001)
- Reilly, M. P. et al. 2011. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. The Lancet 377(9763), pp. 383-392. (10.1016/S0140-6736(10)61996-4)
- Williams, H. J. et al. 2011. Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries. Human Molecular Genetics 20(2), pp. 387-391. (10.1093/hmg/ddq471)
- Bridges, M. et al. 2011. Genetic classification of populations using supervised learning. PLoS ONE 6(5), article number: e14802. (10.1371/journal.pone.0014802)
- Hamshere, M. L. et al. 2011. Polygenic dissection of the bipolar phenotype. British Journal of Psychiatry 198(4), pp. 284-288. (10.1192/bjp.bp.110.087866)
- Williams, N. M., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2011. Structural variations in attention-deficit hyperactivity disorder - Authors' reply [Letter]. The Lancet 377(9763), pp. 378. (10.1016/S0140-6736(11)60121-9)
- Green, E. K. et al. 2011. DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(4), pp. 490-492. (10.1002/ajmg.b.31187)
- Smith, R. L. et al. 2011. Analysis of neurogranin (NRGN) in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(5), pp. 532-535. (10.1002/ajmg.b.31191)
- Sims, R. et al. 2011. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(7), pp. 764-771. (10.1002/ajmg.b.31216)
- Williams, H. J., Escott-Price, V., Smith, R. L., Dwyer, S. L., Russo, G., Owen, M. J. and O'Donovan, M. C. 2011. Association between TCF4 and schizophrenia does not exert its effect by common nonsynonymous variation or by influencing cis-acting regulation of mRNA expression in adult human brain. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(7), pp. 781-784. (10.1002/ajmg.b.31219)
- Carroll, L. S., Williams, H. J., Walters, J. T. R., Kirov, G., O'Donovan, M. C. and Owen, M. J. 2011. Mutation screening of the 3q29 microdeletion syndrome candidate genes DLG1 and PAK2 in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(7), pp. 844-849. (10.1002/ajmg.b.31231)
- Hamshere, M. L. et al. 2011. Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 929-940. (10.1002/ajmg.b.31240)
- Escott-Price, V., O'Dushlaine, C., Purcell, S., Craddock, N. J., Holmans, P. A. and O'Donovan, M. C. 2011. Evaluation of an approximation method for assessment of overall significance of multiple-dependent tests in a genomewide association study. Genetic Epidemiology 35(8), pp. 861-866. (10.1002/gepi.20636)
- Cichon, S. et al. 2011. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. American Journal of Human Genetics 88(3), pp. 372-381. (10.1016/j.ajhg.2011.01.017)
- Hansen, T. et al. 2011. At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia. Biological Psychiatry 70(1), pp. 59-63. (10.1016/j.biopsych.2011.01.031)
- Donohoe, G. et al. 2011. A neuropsychological investigation of the genome wide associated schizophrenia risk variant NRGN rs12807809 [Letter]. Schizophrenia Research 125(2-3), pp. 304-306. (10.1016/j.schres.2010.10.019)
- Steinberg, S. et al. 2011. Common variants at VRK2 and TCF4 conferring risk of schizophrenia. Human Molecular Genetics 20(20), pp. 4076-4081. (10.1093/hmg/ddr325)
- Yosifova, A. et al. 2011. Genome-wide association study on bipolar disorder in the Bulgarian population. Genes, Brain and Behavior 10(7), pp. 789-797. (10.1111/j.1601-183X.2011.00721.x)
- Owen, M. J., O'Donovan, M. C., Thapar, A. and Craddock, N. J. 2011. Neurodevelopmental hypothesis of schizophrenia. British Journal of Psychiatry 198(3), pp. 173-175. (10.1192/bjp.bp.110.084384)
- Wiles, N. J. et al. 2011. Severity of depression and response to antidepressants: GENPOD randomised controlled trial. British Journal of Psychiatry 200(2), pp. 130-136. (10.1192/bjp.bp.110.091223)
- Lips, E. S. et al. 2011. Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia. Molecular Psychiatry, pp. 1-11. (10.1038/mp.2011.117)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
- Dwyer, S. L. et al. 2011. Investigation of rare non-synonymous variants at ABCA13 in schizophrenia and bipolar disorder [letter]. Molecular Psychiatry 16(8), pp. 790-791. (10.1038/mp.2011.2)
- Ruderfer, D. M. et al. 2011. A family-based study of common polygenic variation and risk of schizophrenia [Letter]. Molecular Psychiatry 16(9), pp. 887-888. (10.1038/mp.2011.34)
- Rietschel, M. et al. 2011. Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe. Molecular Psychiatry, pp. 1-12. (10.1038/mp.2011.80)
- Langley, K., Heron, J., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2010. Genotype link with extreme antisocial behavior: The contribution of cognitive pathways. Archives of General Psychiatry 67(12), pp. 1317-1323. (10.1001/archgenpsychiatry.2010.163)
- Carroll, L. S. et al. 2010. Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha. Molecular Psychiatry 15(11), pp. 1101-1111. (10.1038/mp.2009.96)
- Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype [Corrigendum]. Molecular Psychiatry 15(11), pp. 1121-1121. (10.1038/mp.2010.62)
- Jones, L. et al. 2010. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS ONE 5(11), article number: e13950. (10.1371/journal.pone.0013950)
- Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376(9750), pp. 1401-1408. (10.1016/S0140-6736(10)61109-9)
- Green, E. K. et al. 2010. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Molecular Psychiatry 15(10), pp. 1016-1022. (10.1038/mp.2009.49)
- Allison, D. B. et al. 2010. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genetics 6(9), article number: e1001097. (10.1371/journal.pgen.1001097)
- Pagnamenta, A. T. et al. 2010. Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biological psychiatry 68(4), pp. 320-328. (10.1016/j.biopsych.2010.02.002)
- Escott-Price, V. et al. 2010. Genetic differences between five European populations. Human Heredity 70(2), pp. 141-149. (10.1159/000313854)
- Walters, J. T. R. et al. 2010. Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Archives of General Psychiatry 67(7), pp. 692-700. (10.1001/archgenpsychiatry.2010.81)
- Grozeva, D. et al. 2010. Rare copy number variants: A point of rarity in genetic risk for bipolar disorder and schizophrenia. Archives of General Psychiatry 67(4), pp. 318-327. (10.1001/archgenpsychiatry.2010.25)
- Craddock, N. J. et al. 2010. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 464(7289), pp. 713-720. (10.1038/nature08979)
- Langley, K. et al. 2010. Adolescent clinical outcomes for young people with attention-deficit hyperactivity disorder. British Journal of Psychiatry 196(3), pp. 235-240. (10.1192/bjp.bp.109.066274)
- Craddock, N. J. et al. 2010. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Molecular Psychiatry 15(2), pp. 146-153. (10.1038/mp.2008.66)
- Ikeda, M. et al. 2010. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. Biological psychiatry 67(3), pp. 263-269. (10.1016/j.biopsych.2009.08.030)
- Ikeda, M. et al. 2010. Copy number variation in schizophrenia in the Japanese population. Biological Psychiatry 67(3), pp. 283-286. (10.1016/j.biopsych.2009.08.034)
- Mechelli, A. et al. 2010. Dysbindin modulates brain function during visual processing in children. NeuroImage 49(1), pp. 817-822. (10.1016/j.neuroimage.2009.07.030)
- Owen, M. J., Craddock, N. J. and O'Donovan, M. C. 2010. Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia. Archives of General Psychiatry 67(7), pp. 667-673. (10.1001/archgenpsychiatry.2010.69)
- Ikeda, M. et al. 2010. Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(4), pp. 980-982. (10.1002/ajmg.b.31060)
- Green, E. K. et al. 2010. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(7), pp. 1347-1349. (10.1002/ajmg.b.31108)
- Dwyer, S. L., Williams, H., Holmans, P. A., Escott-Price, V., Craddock, N. J., Owen, M. J. and O'Donovan, M. C. 2010. No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(8), pp. 1411-1416. (10.1002/ajmg.b.31117)
- Talkowski, M. E. et al. 2010. Fine-mapping reveals novel alternative splicing of the dopamine transporter. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(8), pp. 1434-1447. (10.1002/ajmg.b.31125)
- Neale, B. M. et al. 2010. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry 49(9), pp. 884-897. (10.1016/j.jaac.2010.06.008)
- Blake, D. J., Forrest, M., Chapman, R. M., Tinsley, C. L., O'Donovan, M. C. and Owen, M. J. 2010. TCF4, Schizophrenia, and Pitt-Hopkins Syndrome. Schizophrenia Bulletin 36(3), pp. 443-447. (10.1093/schbul/sbq035)
- Liu, Y. et al. 2010. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder [Letter]. Molecular Psychiatry 16(1), pp. 2-4. (10.1038/mp.2009.107)
- Breuer, R. et al. 2010. Independent evidence for the selective influence of GABAA receptors on one component of the bipolar disorder phenotype [letter]. Molecular Psychiatry 16(6), pp. 587-589. (10.1038/mp.2010.67)
- Chen, X. et al. 2010. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Molecular Psychiatry 16(11), pp. 1117-1129. (10.1038/mp.2010.96)
- Fowler, T. A. et al. 2009. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatric Genetics 19(6), pp. 312-319. (10.1097/YPG.0b013e3283328df4)
- Hayesmoore, J. B. G., Bray, N. J., Cross, W. C., Owen, M. J., O'Donovan, M. C. and Morris, H. R. 2009. The effect of age and the H1c MAPT haplotype on MAPT expression in human brain. Neurobiology of Aging 30(10), pp. 1652-1656. (10.1016/j.neurobiolaging.2007.12.017)
- Liu, Y. et al. 2009. Whole genome association study in a homogenous population in Shandong Peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia. Journal of Biomedicine and Biotechnology, article number: 536918. (10.1155/2009/536918)
- Harold, D. et al. 2009. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Letter]. Nature Genetics 41(10), pp. 1088-1093. (10.1038/ng.440)
- Donohoe, G. et al. 2009. Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects. Archives of General Psychiatry 66(10), pp. 1045-1054. (10.1001/archgenpsychiatry.2009.139)
- McCarthy, S. E. et al. 2009. Microduplications of 16p11.2 are associated with schizophrenia. Nature Genetics 41(11), pp. 1223-1227. (10.1038/ng.474)
- Ng, M. Y. M. et al. 2009. Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Molecular Psychiatry 14(8), pp. 774-785. (10.1038/mp.2008.135)
- Holmans, P. A. et al. 2009. Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms. Molecular Psychiatry 14(8), pp. 786-795. (10.1038/mp.2009.11)
- Orozco, G. et al. 2009. Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Human Molecular Genetics 18(14), pp. 2693-2699. (10.1093/hmg/ddp193)
- Holmans, P. A. et al. 2009. Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. American Journal of Human Genetics 85(1), pp. 13-24. (10.1016/j.ajhg.2009.05.011)
- O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2009. Genetics of psychosis; insights from views across the genome. Human Genetics 126(1), pp. 3-12. (10.1007/s00439-009-0703-0)
- Raychaudhuri, S. et al. 2009. Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions. Plos Genetics 5(6), pp. -. (10.1371/journal.pgen.1000534)
- Kirov, G. et al. 2009. Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Human Molecular Genetics 18(8), pp. 1497-1503. (10.1093/hmg/ddp043)
- Escott-Price, V. et al. 2009. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Molecular Psychiatry 14(3), pp. 252-260. (10.1038/mp.2008.133)
- O'Donovan, M. C. et al. 2009. Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry 14(1), pp. 30-36. (10.1038/mp.2008.108)
- Hamshere, M. L. et al. 2009. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. British Journal of Psychiatry 195(1), pp. 23-29. (10.1192/bjp.bp.108.061424)
- Harold, D. et al. 2009. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [Corrigendum]. Nature Genetics 41(10), pp. 1156. (10.1038/ng1009-1156d)
- Purcell, S. M. et al. 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460(7256), pp. 748-752. (10.1038/nature08185)
- Williams, H., Owen, M. J. and O'Donovan, M. C. 2009. Schizophrenia genetics: new insights from new approaches. British Medical Bulletin 91(1), pp. 61-74. (10.1093/bmb/ldp017)
- O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2009. Strong evidence for multiple psychosis susceptibility genes - a rejoinder to Crow [Letter]. Psychological Medicine 39(1), pp. 170-171. (10.1017/S0033291708004583)
- Langley, K. et al. 2009. Molecular genetic contribution to the developmental course of attention-deficit hyperactivity disorder. European Child & Adolescent Psychiatry 18(1), pp. 26-32. (10.1007/s00787-008-0698-4)
- Morgan, A. R. et al. 2009. Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(1), pp. 61-64. (10.1002/ajmg.b.30768)
- Talkowski, M. E. et al. 2009. Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samples. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(4), pp. 560-569. (10.1002/ajmg.b.30862)
- Carroll, L. S., Kendall, K., O'Donovan, M. C., Owen, M. J. and Williams, N. M. 2009. Evidence that putative ADHD low risk alleles atSNAP25may increase the risk of schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(7), pp. 893-899. (10.1002/ajmg.b.30915)
- Green, E. K. et al. 2009. P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(8), pp. 1063-1069. (10.1002/ajmg.b.30931)
- Abraham, R. A., Sims, R., Carroll, L. S., Hollingworth, P., O'Donovan, M. C., Williams, J. and Owen, M. J. 2009. An association study of common variation at theMAPTlocus with late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B(8), pp. 1152-1155. (10.1002/ajmg.b.30951)
- Dwyer, S. L., Carroll, L. S., Mantripragada, K. K., Owen, M. J., O'Donovan, M. C. and Williams, N. M. 2009. Mutation screening of the DTNBP1 exonic sequence in 669 schizophrenics and 710 controls using high-resolution melting analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(3), pp. 766-774. (10.1002/ajmg.b.31045)
- O'Donovan, M. C. and Owen, M. J. 2009. Genetics and the brain: many pathways to enlightenment [Editorial]. Human Genetics 126(1), pp. 1-2. (10.1007/s00439-009-0705-y)
- Owen, M. J., Williams, H. J. and O'Donovan, M. C. 2009. Schizophrenia genetics: advancing on two fronts. Current Opinion in Genetics & Development 19(3), pp. 266-270. (10.1016/j.gde.2009.02.008)
- Gerrish, A., Williams, H. J., Escott-Price, V., Owen, M. J., O'Donovan, M. C. and Williams, N. M. 2009. An examination of MUTED as a schizophrenia susceptibility gene [Letter]. Schizophrenia Research 107(1), pp. 110-111. (10.1016/j.schres.2008.08.011)
- Sims, R. et al. 2009. Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease. Neuroscience Letters 461(1), pp. 54-59. (10.1016/j.neulet.2009.05.051)
- Yosifova, A. et al. 2009. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. Journal of Affective Disorders 117(1-2), pp. 87-97. (10.1016/j.jad.2008.12.021)
- Ingason, A. et al. 2009. A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Human Molecular Genetics 19(7), pp. 1379-1386. (10.1093/hmg/ddq009)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2009. Psychosis genetics: modeling the relationship between Schizophrenia, Bipolar Disorder, and Mixed (or "Schizoaffective") Psychoses. Schizophrenia Bulletin 35(3), pp. 482-490. (10.1093/schbul/sbp020)
- Kirov, G., Rujescu, D., Ingason, A., Collier, D. A., O'Donovan, M. C. and Owen, M. J. 2009. Neurexin 1 (NRXN1) deletions in Schizophrenia. Schizophrenia Bulletin 35(5), pp. 851-854. (10.1093/schbul/sbp079)
- Fowler, T. A. et al. 2009. Psychopathy traits in adolescents with childhood attention-deficit hyperactivity disorder. British Journal of Psychiatry 194(1), pp. 62-67. (10.1192/bjp.bp.107.046870)
- Williams, H. J., Owen, M. J. and O'Donovan, M. C. 2009. New findings from genetic association studies of schizophrenia. Journal of Human Genetics 54(1), pp. 9-14. (10.1038/jhg.2008.7)
- Betcheva, E. T. et al. 2009. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. Journal of Human Genetics 54(2), pp. 98-107. (10.1038/jhg.2008.14)
- Barton, A. et al. 2008. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics 40(10), pp. 1156-1159. (10.1038/ng.218)
- Hayesmoore, J. B., Bray, N. J., Owen, M. J. and O'Donovan, M. C. 2008. DISC1mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(7), pp. 1065-1069. (10.1002/ajmg.b.30715)
- Ikeda, M. et al. 2008. Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia. Pharmacogenomics 9(10), pp. 1437-1443. (10.2217/14622416.9.10.1437)
- Craddock, N. J. et al. 2008. Wake up call: Response from authors [eLetter]. British Journal of Psychiatry
- Abraham, R. et al. 2008. A genome-wide association study for late-onset Alzheimer's disease using DNA pooling. BMC Medical Genomics 1(1), article number: 44. (10.1186/1755-8794-1-44)
- Ferreira, M. A. R. et al. 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genetics 40(9), pp. 1056-1058. (10.1038/ng.209)
- Georgieva, L. et al. 2008. Support for Neuregulin 1 as a susceptibility gene for Bipolar disorder and schizophrenia. Biological psychiatry 64(5), pp. 419-427. (10.1016/j.biopsych.2008.03.025)
- Barton, A. et al. 2008. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Human Molecular Genetics 17(15), pp. 2274-2279. (10.1093/hmg/ddn128)
- Loos, R. J. F. et al. 2008. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 40(6), pp. 768-775. (10.1038/ng.140)
- Fisher, S. A. et al. 2008. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics 40(6), pp. 710-712. (10.1038/ng.145)
- Thomas, L. et al. 2008. GENetic and clinical predictors of treatment response in depression: the GenPod randomised trial protocol. Trials 9(1), pp. 29-29. (10.1186/1745-6215-9-29)
- Zaharieva, I., Georgieva, L., Nikolov, I., Kirov, G., Owen, M. J., O'Donovan, M. C. and Toncheva, D. 2008. Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping. BMC Psychiatry 8(1), pp. 11-11. (10.1186/1471-244X-8-11)
- Williams, N. M. et al. 2008. Strong evidence that GNB1L is associated with schizophrenia. Human Molecular Genetics 17(4), pp. 555-566. (10.1093/hmg/ddm330)
- Kirov, G. et al. 2008. Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. Human Molecular Genetics 17(3), pp. 458-465. (10.1093/hmg/ddm323)
- Buxbaum, J. D. et al. 2008. Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Molecular psychiatry 13, pp. 162-172. (10.1038/sj.mp.4001991)
- Williams, N. M. et al. 2008. Analysis of copy number variation using quantitative interspecies competitive PCR. Nucleic Acids Research 36(17), pp. e112-e112. (10.1093/nar/gkn495)
- Kirov, G. et al. 2008. A genome-wide association study in 574 schizophrenia trios using DNA pooling. Molecular Psychiatry 14(8), pp. 796-803. (10.1038/mp.2008.33)
- Stone, J. L. et al. 2008. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455(7210), pp. 237-241. (10.1038/nature07239)
- Caspi, A. et al. 2008. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 65(2), pp. 203-210. (10.1001/archgenpsychiatry.2007.24)
- Langley, K. et al. 2008. Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(1), pp. 49-53. (10.1002/ajmg.b.30571)
- Li, Y. et al. 2008. SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiology of Disease 29(2), pp. 293-296. (10.1016/j.nbd.2007.09.001)
- Li, Y. et al. 2008. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human Molecular Genetics 17(5), pp. 759-767. (10.1093/hmg/ddm348)
- Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17(8), pp. 1169-1174. (10.1093/hmg/ddn006)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2008. Genome-wide association studies in psychiatry: lessons from early studies of non-psychiatric and psychiatric phenotypes [Guest Editorial]. Molecular Psychiatry 13(7), pp. 649-653. (10.1038/mp.2008.45)
- Craddock, N. J. et al. 2008. Authors' reply. The British Journal of Psychiatry 193(6), pp. 517. (10.1192/bjp.193.6.517)
- Shifman, S. et al. 2008. Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLOS Genetics 4(2), article number: e28. (10.1371/journal.pgen.0040028)
- Craddock, N. J. et al. 2008. Wake-up call for British psychiatry. British Journal of Psychiatry 193(1), pp. 6-9. (10.1192/bjp.bp.108.053561)
- Fekadu, A. et al. 2008. Validity of the concept of minor depression in a developing country setting. Journal of Nervous and Mental Disease 196(1), pp. 22-28. (10.1097/NMD.0b013e31815fa4d4)
- O'Donovan, M. C. et al. 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nature Genetics 40(9), pp. 1053-1055. (10.1038/ng.201)
- O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2008. Schizophrenia: complex genetics, not fairy tales. Psychological Medicine 38(12), pp. 1697-1699. (10.1017/S0033291708003802)
- O'Donovan, M. C., Kirov, G. and Owen, M. J. 2008. Phenotypic variations on the theme of CNVs. Nature Genetics 40(12), pp. 1392-1393. (10.1038/ng1208-1392)
- Richards, A. L., Holmans, P. A., O'Donovan, M. C., Owen, M. J. and Jones, L. 2008. A comparison of four clustering methods for brain expression microarray data. BMC Bioinformatics 9, article number: 490. (10.1186/1471-2105-9-490)
- Nejentsev, S. et al. 2007. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 450(7171), pp. 887-892. (10.1038/nature06406)
- Thomson, W. et al. 2007. Rheumatoid arthritis association at 6q23. Nature Genetics 39(12), pp. 1431-1433. (10.1038/ng.2007.32)
- Williams, H. et al. 2007. Association analysis of the glial cell line-derived neurotrophic factor (GDNF) gene in schizophrenia. Schizophrenia Research 97(1-3), pp. 271-276. (10.1016/j.schres.2007.09.004)
- Thapar, A., Langley, K., Owen, M. J. and O'Donovan, M. C. 2007. Advances in genetic findings on attention deficit hyperactivity disorder. Psychological Medicine 37(12), pp. 1681-1692. (10.1017/S0033291707000773)
- Zammit, S., Spurlock, G., Williams, H., Norton, N., Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2007. Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. British Journal of Psychiatry 191(5), pp. 402-407. (10.1192/bjp.bp.107.036129)
- Hollingworth, P. et al. 2007. Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(7), pp. 841-848. (10.1002/ajmg.b.30515)
- Morgan, A. et al. 2007. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(6), pp. 762-770. (10.1002/ajmg.b.30509)
- Thapar, A., Harold, G. T., Rice, F., Langley, K. and O'Donovan, M. C. 2007. The contribution of gene-environment interaction to psychopathology. Development and Psychopathology 19(4), pp. 989-1004. (10.1017/S0954579407000491)
- Hamshere, M. L. et al. 2007. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics Advanc, pp. 1-34. (10.1093/hmg/ddm224)
- Domschke, K., Deckert, J., O'Donovan, M. C. and Glatt, S. J. 2007. Meta-analysis of COMT val158met in panic disorder: Ethnic heterogeneity and gender specificity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(5), pp. 667-673. (10.1002/ajmg.b.30494)
- Norton, N. et al. 2007. Association analysis of AKT1 and schizophrenia in a UK case control sample. Schizophrenia Research 93(1-3), pp. 58-65. (10.1016/j.schres.2007.02.006)
- Burton, P. R. et al. 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145), pp. 661-678. (10.1038/nature05911)
- Harold, D. et al. 2007. Interaction between theADAM12 andSH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(4), pp. 448-452. (10.1002/ajmg.b.30456)
- Hamilton, G. et al. 2007. Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(4), pp. 508-516. (10.1002/ajmg.b.30503)
- Williams, H., Owen, M. J. and O'Donovan, M. C. 2007. Is COMT a susceptibility gene for schizophrenia?. Schizophrenia Bulletin 33(3), pp. 635-641. (10.1093/schbul/sbm019)
- Escott-Price, V. and O'Donovan, M. C. 2007. Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation. Human Heredity 64(1), pp. 63-73. (10.1159/000101424)
- O'Donovan, M. C. et al. 2007. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia [Conference Abstract]. Schizophrenia bulletin 33(2), pp. 311-312. (10.1093/schbul/sbm004)
- Grupe, A. et al. 2007. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics 16(8), pp. 865-873. (10.1093/hmg/ddm031)
- Gunnell, D. et al. 2007. IGF1, growth pathway polymorphisms and schizophrenia: A pooling study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B(1), pp. 117-120. (10.1002/ajmg.b.30396)
- Hamilton, G., Proitsi, P., Williams, J., O'Donovan, M. C., Owen, M. J., Powell, J. and Lovestone, S. 2007. Complement factor H Y402H polymorphism is not associated with late-onset Alzheimer's disease. Neuromolecular Medicine 9(4), pp. 331-334. (10.1007/s12017-007-8013-y)
- Morgan, A. et al. 2007. Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(6), pp. 727-731. (10.1002/ajmg.b.30670)
- Talkowski, M. E. et al. 2007. A network of dopaminergic gene variations implicated as risk factors for schizophrenia. Human Molecular Genetics 17(5), pp. 747-758. (10.1093/hmg/ddm347)
- Thapar, A. et al. 2007. Promoting Measured Genes and Measured Environments: On the Importance of Careful Statistical Analyses and Biological Relevance—Reply [Letter]. Archives of General Psychiatry 64(3), pp. 378-379. (10.1001/archpsyc.64.3.378-b)
- Burton, P. R. et al. 2007. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics 39(11), pp. 1329-1337. (10.1038/ng.2007.17)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2007. Symptom dimensions and the Kraepelinian dichotomy. British Journal of Psychiatry 190(4), pp. 361. (10.1192/bjp.190.4.361)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2007. Phenotypic and genetic complexity of psychosis Invited commentary on .. Schizophrenia: a common disease caused by multiple rare alleles. British Journal of Psychiatry 190(3), pp. 200-203. (10.1192/bjp.bp.106.033761)
- Harold, D. et al. 2006. Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. Molecular Psychiatry 11(12), pp. 1085-91. (10.1038/sj.mp.4001904)
- O'Donovan, M. et al. 2006. Genetic dissection of behavioural abnormalities in mouse models of DiGeorge/velocardiofacial syndrome. Journal of intellectual disability research 50(11), pp. 781 -781.
- Glaser, B. et al. 2006. Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility. Schizophrenia Research 87(1-3), pp. 21. (10.1016/j.schres.2006.05.024)
- Zammit, S. et al. 2006. Phenotypic variation between parent-offspring trios and non-trios in genetic studies of schizophrenia. Journal of Psychiatric Research 40(7), pp. 622-626. (10.1016/j.jpsychires.2005.05.006)
- Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(7), pp. 723-724.
- Li, Y. et al. 2006. DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Human Molecular Genetics 15(17), pp. 2560-2568. (10.1093/hmg/ddl178)
- Georgieva, L. et al. 2006. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 103(33), pp. 12469-12474. (10.1073/pnas.0603029103)
- Bray, N. J. and O'Donovan, M. C. 2006. Investigating cis-acting regulatory variation using assays of relative allelic expression. Psychiatric Genetics 16(4), pp. 173-177. (10.1097/01.ypg.0000218612.35139.84)
- Thapar, A., Langley, K., O'Donovan, M. C. and Owen, M. J. 2006. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 11(8), pp. 714-20. (10.1038/sj.mp.4001831)
- Talkowski, M. E. et al. 2006. Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. Biological psychiatry 60(2), pp. 152-162. (10.1016/j.biopsych.2006.02.015)
- Williams, J. and O'Donovan, M. C. 2006. The genetics of developmental dyslexia. European Journal of Human Genetics 14(6), pp. 681-89. (10.1038/sj.ejhg.5201575)
- Hamilton, G. et al. 2006. Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease. Neuroscience Letters 401(1-2), pp. 77-80. (10.1016/j.neulet.2006.03.021)
- Paylor, R. et al. 2006. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: Implications for 22q11 deletion syndrome. Proceedings of the National Academy of Sciences of the United States of America 103(20), pp. 7729-7734. (10.1073/pnas.0600206103)
- Williams, N. M. et al. 2006. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Archives of General Psychiatry 63(4), pp. 366-373. (10.1001/archpsyc.63.4.366)
- Escott-Price, V., Craddock, N. J., Holmans, P. A., Owen, M. J. and O'Donovan, M. C. 2006. Effects of differential genotyping error rate on the Type 1 error probability of case-control studies. Human heredity 61(1), pp. 55-64. (10.1159/000092553)
- Kirov, G., Nikolov, I., Georgieva, L., Escott-Price, V., Owen, M. J. and O'Donovan, M. C. 2006. Pooled DNA genotyping on Affymetrix SNP genotyping arrays. BMC Genomics 7(1), pp. 27-37. (10.1186/1471-2164-7-27)
- Harold, D. et al. 2006. A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease. Pharmacogenetics and genomics 16(2), pp. 75-77.
- Khan, I. A., Mort, M., Buckland, P. R., O'Donovan, M. C., Cooper, D. N. and Chuzhanova, N. A. 2006. In silico discrimination of single nucleotide polymorphisms and pathological mutations in human gene promoter regions by means of local DNA sequence context and regularity.. In silico Biology 6(1-2), pp. 23-34.
- Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2006. Chromosome 22 deletion syndrome and schizophrenia. International Review of Neurobiology 73, pp. 1-27. (10.1016/S0074-7742(06)73001-X)
- Smemo, S. et al. 2006. Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Annals of Neurology 59(1), pp. 21-26. (10.1002/ana.20673)
- Grupe, A. et al. 2006. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. The American Journal of Human Genetics 78(1), pp. 78-88.
- Peirce, T. R. et al. 2006. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of general psychiatry 63(1), pp. 18-24. (10.1001/archpsyc.63.1.18)
- Peirce, T. et al. 2006. Convergent evidence for 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of General Psychiatry 63(1), pp. 18-24.
- Norton, N. et al. 2006. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(1), pp. 96-101. (10.1002/ajmg.b.30236)
- Green, E. K. et al. 2006. Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation. Molecular Psychiatry 11(9), pp. 798-799. (10.1038/sj.mp.4001853)
- Hamshere, M. L. et al. 2006. Genome wide significant linkage in schizophrenia conditioning on occurrence of depressive episodes. Journal of Medical Genetics 43(7), pp. 563-567. (10.1136/jmg.2005.035345)
- Craddock, N. J., Owen, M. J. and O'Donovan, M. C. 2006. The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons. Molecular Psychiatry 11(5), pp. 446-458. (10.1038/sj.mp.4001808)
- Green, E. K. et al. 2006. Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK. British Journal of Psychiatry 188(1), pp. 21-25. (10.1192/bjp.bp.105.009969)
- Langley, K. et al. 2005. No support for association between the dopamine transporter (DAT1) gene and ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 139B(1), pp. 7-10. (10.1002/ajmg.b.30206)
- Gough, S. C. and O'Donovan, M. C. 2005. Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?. Journal of Psychopharmacology 19(6), pp. 47-55. (10.1177/0269881105058380)
- Thapar, A. et al. 2005. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder. Archives of General Psychiatry 62(11), pp. 1275-1278. (10.1001/archpsyc.62.11.1275)
- Thapar, A., O'Donovan, M. C. and Owen, M. J. 2005. The genetics of attention deficit hyperactivity disorder. Human Molecular Genetics 14(2), pp. 275-282. (10.1093/hmg/ddi263)
- Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2005. Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?. Schizophrenia Bulletin 31(4), pp. 800-805. (10.1093/schbul/sbi061)
- Hamshere, M. L. et al. 2005. Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Archives of general psychiatry 62(10), pp. 1081-1088. (10.1001/archpsyc.62.10.1081)
- Buckland, P. R., Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K. and O'Donovan, M. C. 2005. Strong bias in the location of functional promoter polymorphisms. Human Mutation 26(3), pp. 214-223. (10.1002/humu.20207)
- Williams, H. J. et al. 2005. No association between schizophrenia and polymorphisms in COMT in two large samples. American Journal of Psychiatry 162(9), pp. 1736-1738. (10.1176/appi.ajp.162.9.1736)
- Redfern, A. et al. 2005. Global gene expression profiling in the hippocampus and frontal cortex of Escitalopram-treated Learned Helplessness rats. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 138B(1), pp. 107-107.
- Nowotny, P. et al. 2005. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 136B(1), pp. 62-68. (10.1002/ajmg.b.30186)
- Glaser, B. et al. 2005. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. Biological psychiatry 58(1), pp. 78-80.
- Kirov, G., O'Donovan, M. C. and Owen, M. J. 2005. Finding schizophrenia genes. The Journal of Clinical Investigation 115(6), pp. 1440-1448. (10.1172/JCI24759)
- Turic, D. et al. 2005. A family based study implicates solute carrier family 1-member 3 (SLC1A3) gene in attention-deficit/hyperactivity disorder. Biological psychiatry 57(11), pp. 1461-1466. (10.1016/j.biopsych.2005.03.025)
- O'Donovan, M. C. 2005. An evaluation of chromatin condensation and DNA integrity in the spermatozoa of men with cancer before and after therapy. Andrologia -Berlin- 37(2-3), pp. 83-90. (10.1111/j.1439-0272.2005.00658.x)
- Green, E. K. et al. 2005. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Archives of general psychiatry 62(6), pp. 642-648. (10.1001/archpsyc.62.6.642)
- Norton, N. et al. 2005. No evidence for association between polymorphisms in GRM3 and schizophrenia. BMC Psychiatry 5, article number: 23. (10.1186/1471-244X-5-23)
- Holmans, P. A. et al. 2005. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 135B(1), pp. 24-32. (10.1002/ajmg.b.30114)
- Bray, N. J., Preece, A. C., Williams, N. M., Escott-Price, V., Buckland, P. R., Owen, M. J. and O'Donovan, M. C. 2005. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Human Molecular Genetics 14(14), pp. 1947-1954. (10.1093/hmg/ddi199)
- Cope, N. A. et al. 2005. Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia. American Journal of Human Genetics 76(4), pp. 581-591. (10.1086/429131)
- Escott-Price, V., Norton, N., Williams, N. M., Holmans, P. A., Owen, M. J. and O'Donovan, M. C. 2005. Streamlined analysis of pooled genotype data in SNP-based association studies. Genetic Epidemiology 28(3), pp. 273-282. (10.1002/gepi.20062)
- Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K., Coleman, S. L. and O'Donovan, M. C. 2005. Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. American Journal of Psychiatry 162(3), pp. 613-615. (10.1176/appi.ajp.162.3.613)
- Li, Y. et al. 2005. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Human Mutation 25(3), pp. 270-277. (10.1002/humu.20138)
- Cope, N. A. et al. 2005. No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia. Molecular Psychiatry 10(3), pp. 237-238. (10.1038/sj.mp.4001596)
- Turic, D., Williams, H., Langley, K., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2005. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 133B(1), pp. 64-67. (10.1002/ajmg.b.30123)
- Owen, M. J., O'Donovan, M. C. and Harrison, P. J. 2005. Schizophrenia: a genetic disorder of the synapse?. British Medical Journal (BMJ) 330(7484), pp. 158-159. (10.1136/bmj.330.7484.158)
- Owen, M. J., Craddock, N. J. and O'Donovan, M. C. 2005. Schizophrenia: genes at last?. Trends in Genetics 21(9), pp. 518-525. (10.1016/j.tig.2005.06.011)
- Raybould, R. et al. 2005. Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biological psychiatry 57(7), pp. 696-701. (10.1016/j.biopsych.2005.01.018)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2005. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. Journal of Medical Genetics 42(3), pp. 193-204. (10.1136/jmg.2005.030718)
- Green, E. et al. 2005. Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease. American Journal of Psychiatry 162(1), pp. 35-42. (10.1176/appi.ajp.162.1.35)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 2005. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophrenia Bulletin 32(1), pp. 9-16. (10.1093/schbul/sbj033)
- Kent, L. et al. 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10(10), pp. 939-943. (10.1038/sj.mp.4001696)
- Glaser, B., Kirov, G., Bray, N. J., Green, E., O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2005. Identification of a potential Bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. Molecular Psychiatry 10(10), pp. 920-927. (10.1038/sj.mp.4001689)
- Buckland, P. R. et al. 2004. A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity. Acta Biochimica et Biophysica 1690(3), pp. 238-249.
- Bray, N. J. et al. 2004. Allelic variation in the expression of neuropsychiatric candidate genes [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 25-25.
- Peirce, T. R. et al. 2004. Convergent functional genomics, association and linkage analysis suggests 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase (CNP) as a potential susceptibility gene for schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 81-81. (10.1002/ajmg.b.30101)
- Fowler, T. A. et al. 2004. Early onset antisocial behaviour in children with ADHD is associated with a functional variant in the catechol-O-methyltransferase (COMT) gene [Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 98-98. (10.1002/ajmg.b.30101)
- Bray, N. J., Jehu, L., Escott-Price, V., Buckland, P. R., Williams, J., Owen, M. J. and O'Donovan, M. C. 2004. Allelic expression of APOE in brain [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 61-61.
- Norton, N. et al. 2004. Interaction between neuregulin 1 and its receptor ERBB4 increases susceptibility to schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 18-18.
- Mowry, B. J. et al. 2004. Multicenter linkage study of schizophrenia loci on chromosome 22q. Molecular Psychiatry 9(8), pp. 784-795. (10.1038/sj.mp.4001481)
- Morris, D. et al. 2004. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. American Journal Of Medical Genetics Part A 129B(1), pp. 97-103. (10.1002/ajmg.b.30033)
- Zammit, S. et al. 2004. Polymorphisms in the MAOA, MAOB, and COMT genes and aggressive behavior in schizophrenia. American Journal of Medical Genetics 128B(1), pp. 19-20. (10.1002/ajmg.b.30021)
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2004. Functional analysis of polymorphisms in the promoter regions of genes on 22q11. Human Mutation 24(1), pp. 35-42. (10.1002/humu.20061)
- Bray, N. J., Jehu, L., Escott-Price, V., Buckland, P. R., Owen, M. J., Williams, J. and O'Donovan, M. C. 2004. P4-101 Allelic expression of APOE in brain [Conference Abstract]. Neurobiology of Aging 25, pp. S503-S503. (10.1016/S0197-4580(04)81659-2)
- Mills, S. et al. 2004. No evidence of association between Catechol-O-Methyltransferase (COMT) Val(158)Met genotype and performance on neuropsychological tasks in children with ADHD: A case-control study. BMC Psychiatry 4, pp. 15-15. (10.1186/1471-244X-4-15)
- Plomin, R. et al. 2004. A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability. Molecular Psychiatry 9(6), pp. 582-586. (10.1038/sj.mp.4001441)
- Turic, D., Langley, K., Kirov, G., Owen, M. J., Thapar, A. and O'Donovan, M. C. 2004. Direct analysis of the genes encoding G proteins G alpha T2, G alpha o, G alpha Z in ADHD. American Journal of Medical Genetics 127B(1), pp. 68-72. (10.1002/ajmg.b.20173)
- Kirov, G. et al. 2004. Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biological psychiatry 55(10), pp. 971-975. (10.1016/j.biopsych.2004.01.025)
- Owen, M. J., Williams, N. M. and O'Donovan, M. C. 2004. Dysbindin-1 and schizophrenia: from genetics to neuropathology. The Journal of Clinical Investigation 113(9), pp. 1255-1257. (10.1172/JCI200421470)
- Murphy, K., Williams, H., Owen, M. J. and O'Donovan, M. C. 2004. What can velo-cardio-facial syndrome tell us about the genetics of schizophrenia?. European Psychiatry 19(Supp1), pp. 96S-96S.
- Williams, N. M. et al. 2004. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Archives of General Psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
- Huezo-Diaz, P. et al. 2004. An association study of the neurotensin receptor gene with schizophrenia and clozapine response. Schizophrenia Research 66(2-3), pp. 193-195. (10.1016/S0920-9964(03)00128-2)
- Williams, N. M. et al. 2004. Support for RGS4 as a susceptibility gene for schizophrenia. Biological Psychiatry 55(2), pp. 192-195. (10.1016/j.biopsych.2003.11.002)
- Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J., O'Donovan, M. C. and Thapar, A. 2004. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. American Journal of Psychiatry 161(1), pp. 133-138. (10.1176/appi.ajp.161.1.133)
- Williams, N. M. et al. 2004. Identification in two independent samples of a novel schizophrenia risk haplotype of the dystobrevin binding protein gene (DTNBP1). Archives of general psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
- Guy, C., Hoogendoorn, B., Smith, S. K., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2004. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 14(1), pp. 45-51. (10.1097/00008571-200401000-00005)
- Owen, M. J., Williams, N. M. and O'Donovan, M. C. 2004. The molecular genetics of schizophrenia: new findings promise new insights. Molecular Psychiatry 9(1), pp. 14-27. (10.1038/sj.mp.4001444)
- Myers, A. J. et al. 2004. Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. American Journal of Medical Genetics 124B(1), pp. 29-37. (10.1002/ajmg.b.20036)
- Cichon, S. et al. 2004. Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin. Nature Genetics 36(8), pp. 783-784. (10.1038/ng0804-783)
- Turic, D. et al. 2004. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D aspartate glutamate receptor 2A gene polymorphism with ADHD. Molecular Psychiatry 9(2), pp. 169-173. (10.1038/sj.mp.4001387)
- Norton, N., Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2004. DNA pooling as a tool for large-scale association studies in complex traits. Annals of Medicine 36(2), pp. 146-152. (10.1080/07853890310021724)
- Busby, V. et al. 2004. Alpha-T-Catenin Is Expressed in Human Brain and Interacts With the Wnt Signaling Pathway But Is Not Responsible for Linkage to Chromosome 10 in Alzheimer's Disease. Neuromolecular Medicine 5(2), pp. 133-146. (10.1385/NMM:5:2:133)
- Bray, N. J., Buckland, P. R., Hall, H., Owen, M. J. and O'Donovan, M. C. 2004. The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Molecular Psychiatry 9(1), pp. 109-114. (10.1038/sj.mp.4001366)
- Bray, N. J. et al. 2004. Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes. Human Molecular Genetics 13(22), pp. 2885-2892. (10.1093/hmg/ddh299)
- Williams, N. M. et al. 2003. A systematic genomewide linkage study in 353 sib pairs with schizophrenia. The American journal of human genetics 73(6), pp. 1355-1367. (10.1086/380206)
- Smith, S. K., Hoogendoorn, B., Guy, C., Coleman, S. L., O'Donovan, M. C. and Buckland, P. R. 2003. Lack of functional promoter polymorphisms in genes involved in glutamate neurotransmission. Psychiatric Genetics 13(4), pp. 193-199. (10.1097/00041444-200312000-00001)
- Ivanov, D. et al. 2003. Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis: Molecular genetic study. The British Journal of Psychiatry 183(5), pp. 409-413. (10.1192/bjp.183.5.409)
- Thapar, A., Langley, K., Marshall, L., van den Bree, M. B., Thomas, H. V., Owen, M. J. and O'Donovan, M. C. 2003. ADHD children with and without the dopamine D4 receptor 7-repeat allele: Evidence of differences in performance on neuropsychological tests. Behavior Genetics 33(6), pp. 721-721.
- O'Donovan, M. C., Williams, N. M. and Owen, M. J. 2003. Recent advances in the genetics of schizophrenia. Human Molecular Genetics 12(suppl), pp. R125-R133. (10.1093/hmg/ddg302)
- Kirov, G. et al. 2003. Variation in the protocadherin - A gene cluster?. Genomics 82(4), pp. 433-440. (10.1016/S0888-7543(03)00167-8)
- Hoogendoorn, B., Coleman, S. L., Guy, C., Smith, S. K., Bowen, T., Buckland, P. R. and O'Donovan, M. C. 2003. Functional analysis of human promoter polymorphisms. Human Molecular Genetics 12(18), pp. 2249-2254. (10.1093/hmg/ddg246)
- Payton, A. et al. 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.. Psychiatric Genetics 13(3), pp. 183-185.
- Harold, D. et al. 2003. Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Human Genetics 113(3), pp. 258-267. (10.1007/s00439-003-0960-2)
- Norton, N. et al. 2003. Mutation screening of the Homer gene family and association analysis in schizophrenia. American Journal of Medical Genetics 120B(1), pp. 18-21. (10.1002/ajmg.b.20032)
- Williams, H. et al. 2003. Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia. American Journal of Medical Genetics 120B(1), pp. 42-46. (10.1002/ajmg.b.20049)
- Williams, H. J. et al. 2003. Association between PRODH and schizophrenia is not confirmed. Molecular Psychiatry 8(7), pp. 644-645. (10.1038/sj.mp.4001276)
- Lewis, C. M. et al. 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder, Part II: schizophrenia. American Journal of Human Genetics 73(1), pp. 34-48. (10.1086/376549)
- Bray, N. J., Buckland, P. R., Williams, N. M., Williams, H. J., Norton, N., Owen, M. J. and O'Donovan, M. C. 2003. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. The American Journal of Human Genetics 73(1), pp. 152-161. (10.1086/376578)
- Bray, N. B., Buckland, P. R., Owen, M. J. and O'Donovan, M. C. 2003. Cis-acting variation in the expression of a high proportion of genes in human brain. Human Genetics 113(2), pp. 149-153. (10.1007/s00439-003-0956-y)
- Langley, K. et al. 2003. No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics 13(2), pp. 107-110. (10.1097/01.ypg.0000056177.32550.a5)
- Williams, N. M. et al. 2003. Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Molecular Psychiatry 8(5), pp. 485-487. (10.1038/sj.mp.4001348)
- Turic, D. et al. 2003. Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22. Molecular Psychiatry 8(2), pp. 176-185. (10.1038/sj.mp.4001216)
- Lawson, D. C. et al. 2003. Association analysis of monoamine oxidase a and attention deficit hyperactivity disorder. American Journal of Medical Genetics 116B(1), pp. 84-89. (10.1002/ajmg.b.10002)
- O'Donovan, M. C., Jones, I. R. and Craddock, N. J. 2003. Anticipation and repeat expansion in bipolar disorder. American Journal of Medical Genetics 123C(1), pp. 10-17. (10.1002/ajmg.c.20009)
- Buckland, P. R., Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2003. A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity. Gene Expression 11(5), pp. 233-239. (10.3727/000000003783992225)
- Sham, P., Bader, J. S., Craig, I., O'Donovan, M. C. and Owen, M. J. 2002. DNA Pooling: a tool for large-scale association studies. Nature Reviews Genetics 3(11), pp. 862-871. (10.1038/nrg930)
- Bray, N. J. et al. 2002. Screening the protocadherin 8 (PCDH8) gene in schizophrenia [Conference Abstract]. American Journal of Medical Genetics 114(7), pp. 844-844.
- Bray, N. J., Buckland, P. R., Williams, H., Norton, N., Williams, N. M., Owen, M. J. and O'Donovan, M. C. 2002. Detection of cis-acting polymorphisms and epigenetic modification affecting gene expression [Conference Abstracts]. American Journal of Medical Genetics 114(7), pp. 750-750. (10.1002/ajmg.10971)
- Bray, N. J. et al. 2002. Screening the human protocadherin 8 (PCDH8) gene in schizophrenia. Genes, Brain and Behavior 1(3), pp. 187-191. (10.1034/j.1601-183X.2002.10307.x)
- Coleman, S. L., Hoogendoorn, B., Guy, C., Smith, S. K., O'Donovan, M. C. and Buckland, P. R. 2002. Streamlined approach to functional analysis of promoter-region polymorphisms. Biotechniques 33(2), pp. 412-418.
- Norton, N. et al. 2002. Schizophrenia and functional polymorphisms in the MAOA and COMT genes: No evidence for association or epistasis. American Journal Of Medical Genetics Part A 114(5), pp. 491-496. (10.1002/ajmg.10517)
- Norton, N. et al. 2002. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Human Genetics 110(5), pp. 471-478. (10.1007/s00439-002-0706-6)
- Levinson, D. F. et al. 2002. No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science 296(5568), pp. 739-741. (10.1126/science.1069914)
- Anney, R. et al. 2002. Characterisation, mutation detection, and association analysis of alternative promoters and 5' UTRs of the human dopamine D3 receptor gene in schizophrenia. Molecular psychiatry 7(5), pp. 493-502. (10.1038/sj.mp.4001003)
- Coleman, S. L., Buckland, P. R., Hoogendoorn, B., Guy, C., Smith, S. K. and O'Donovan, M. C. 2002. Experimental analysis of the annotation of promoters in the public database. Human Molecular Genetics 11(16), pp. 1817-1821. (10.1093/hmg/11.16.1817)
- Williams, N. M. et al. 2002. Mutation screening and LD mapping in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach. Molecular Psychiatry 7(10), pp. 1092-1100. (10.1038/sj.mp.4001188)
- Williams, N. M. et al. 2002. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor. Molecular Psychiatry 7(5), pp. 508-514. (10.1038/sj.mp.4001030)
- Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2002. Genome scans and microarrays: converging on genes for schizophrenia?. Genome Biology 3(4), pp. Reviews1011-Reviews1011.5.
- West, A. et al. 2002. Evidence to suggest biased phenotypes in children with Attention Deficit Hyperactivity Disorder from completely ascertained trios. Molecular Psychiatry 7(9), pp. 962-966. (10.1038/sj.mp.4001129)
- Hawi, Z. et al. 2002. Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. Molecular Psychiatry 7(7), pp. 718-725. (10.1038/sj.mp.4001048)
- Jurewicz, I., Owen, R., O'Donovan, M. C. and Owen, M. J. 2001. Searching for susceptibility genes in schizophrenia. European Neuropsychopharmacology 11(6), pp. 395-398. (10.1016/S0924-977X(01)00116-X)
- Abraham, R. et al. 2001. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease. Human Genetics 109(6), pp. 646-652. (10.1007/s00439-001-0614-1)
- Kirov, G., Lowry, C. A., Stephens, M., Oldfield, S., O'Donovan, M. C., Lightman, S. L. and Owen, M. J. 2001. Screening ABCG1, the human homologue of the Drosophila white gene, for polymorphisms and association with bipolar affective disorder. Molecular Psychiatry 6(6), pp. 671-677. (10.1038/sj.mp.4000899)
- Williams, H. et al. 2001. Association analysis of TBX1 and schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 105(7), pp. 561.
- Payton, A. et al. 2001. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. Neuroscience Letters 105(5), pp. 464-470. (10.1002/ajmg.1407)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6(3), pp. 259-260. (10.1038/sj.mp.4000128)
- Jacobsen, N. J. O., Elvidge, G., Franks, E. K. E., O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2001. CUX2, a potential regulator of NCAM expression: Genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder. American Journal of Medical Genetics 105(3), pp. 295-300. (10.1002/ajmg.1325)
- Jacobsen, N. J. O. et al. 2001. Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder. Molecular Psychiatry 6(1), pp. 92-97. (10.1038/sj.mp.4000774)
- Williams, N. et al. 2001. Screening of candidate genes related to myelination for mutations associated with schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 105(7), pp. 589.
- Vincent, J. B. et al. 2000. Long repeat tracts at SCA8 in major psychosis. American Journal of Medical Genetics 96(6), pp. 873-876. (10.1002/1096-8628(20001204)96:6<873::AID-AJMG37>3.0.CO;2-9)
- Bowen, T. et al. 2000. No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder. Bipolar Disorders 2(4), pp. 328-331. (10.1034/j.1399-5618.2000.020406.x)
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Williams, H., Murphy, K., Spurlock, G., O'Donovan, M. and Owen, M. 2000. No association of the -277A variant allele of the UFD1L promoter polymorphism and schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96(4), pp. 533-534.
- Bray, N. J. et al. 2000. No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia. Psychiatric Genetics 10(2), pp. 83-86. (10.1097/00041444-200010020-00005)
- Morris, D. W. et al. 2000. Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q. Human Molecular Genetics 9(5), pp. 843-848. (10.1093/hmg/9.5.843)
- Austin, J. et al. 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10(1), pp. 51-54. (10.1097/00041444-200010010-00009)
- Austin, J. et al. 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5(2), pp. 208-212. (10.1038/sj.mp.4000693)
- Bowen, T. et al. 2000. Repeat sizes at CAG/CTG loci CTG18.1, ERDA1 and TGC13-7a in schizophrenia. Psychiatric Genetics 10(1), pp. 33-37. (10.1097/00041444-200010010-00006)
- Owen, M. J., Cardno, A. G. and O'Donovan, M. C. 2000. Psychiatric genetics: back to the future. Molecular Psychiatry 5(1), pp. 22-31. (10.1038/sj.mp.4000702)
- Kirov, G., Stephens, M., Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2000. Automated genotyping of single-nucleotide polymorphisms by extension of fluorescently labelled primers: analysis of individual and pooled DNA samples. Balkan Journal of Medical Genetics 3, pp. 23-28.
- Cardno, A. G., O'Donovan, M. C. and Owen, M. J. 2000. Genetic risk factors for schizophrenia. International Journal of Mental Health 29(3), pp. 13-38.
- Williams, N. et al. 2000. Identification and characterisation of SNPs in candidate genes for schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96(4), pp. 462.
- Williams, N. et al. 2000. Linkage disequilibrium mapping and candidate gene screening of the VCFS deleted region for mutations associated with schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics 96(4), pp. 475.
- Speight, G. et al. 2000. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Molecular Psychiatry 5(3), pp. 327-331. (10.1038/sj.mp.4000717)
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)
- O'Donovan, M. C. and Owen, M. J. 1999. Candidate-gene association studies of schizophrenia. American Journal of Human Genetics 65(3), pp. 587-592. (10.1086/302560)
- Jacobsen, N. J. et al. 1999. ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes. Human Molecular Genetics 8(9), pp. 1631-1636. (10.1093/hmg/8.9.1631)
- Guy, C., Bowen, T., Jones, I. R., McCandless, F., Owen, M. J., Craddock, N. J. and O'Donovan, M. C. 1999. CTG18.1 and ERDA-1 CAG/CTG repeat size in bipolar disorder. Neurobiology of Disease 6(4), pp. 302-307. (10.1006/nbdi.1999.0249)
- Jones, A. C., Austin, J., Hansen, N., Hoogendoorn, B., Oefner, P. J., Cheadle, J. P. and O'Donovan, M. C. 1999. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis. Clinical Chemistry 45(8), pp. 1133-1140.
- Cardno, A. G. et al. 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45(12), pp. 1592-1596. (10.1016/s0006-3223(99)00033-5)
- Sakuntabhai, A. et al. 1999. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nature Genetics 21(3), pp. 271-277.
- Franks, E., Guy, C., Jacobsen, N., Bowen, T., Owen, M. J., O'Donovan, M. C. and Craddock, N. J. 1999. Eleven trinucleotide repeat loci that map to chromosome 12 excluded from involvement in the pathogenesis of bipolar disorder. American Journal of Medical Genetics 88(1), pp. 67-70. (10.1002/(SICI)1096-8628(19990205)88:1<67::AID-AJMG12>3.0.CO;2-#)
- Guy, C. et al. 1999. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88(1), pp. 57-60. (10.1002/(sici)1096-8628(19990205)88:1%3C57::aid-ajmg10%3E3.0.co;2-6)
- Hoogendoorn, B., Owen, M. J., Oefner, P. J., Williams, N. M., Austin, J. and O'Donovan, M. C. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104(1), pp. 89-93. (10.1007/s004390050915)
- Li, T. et al. 1998. Analysis of CAG/CTG repeat size in Chinese subjects with schizophrenia and bipolar affective disorder using the repeat expansion detection method. Biological psychiatry 44(11), pp. 1160-1165. (10.1016/S0006-3223(97)00492-7)
- O'Donovan, M. C. et al. 1998. Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection. Genomics 52(1), pp. 44-49. (10.1006/geno.1998.5411)
- Bowen, T. et al. 1998. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Molecular Psychiatry 3(3), pp. 266-269. (10.1038/sj.mp.4000400)
- Oretti, R. G., O'Donovan, M. C., McGuffin, P. and Buckland, P. R. 1998. Tryptophan pyrrolase gene expression in an alcohol preferring and non-preferring mouse strain. Addiction Biology 3(1), pp. 71-77. (10.1080/13556219872362)
- Bowen, T. et al. 1998. Linked polymorphisms upstream of exons 1 and 2 of the human cholecystokinin gene are not associated with schizophrenia or bipolar disorder. Molecular Psychiatry 3(1), pp. 67-71. (10.1038/sj.mp.4000293)
- Cardno, A. G. et al. 1998. Association between functional psychosis and expanded CAG/CTG repeats is not explained by health stratification [comparative study]. Psychiatric Genetics 8(1), pp. 29-32. (10.1097/00041444-199800810-00005)
- Jones, L. et al. 1997. No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia. Molecular Psychiatry 2(6), pp. 478-482. (10.1038/sj.mp.4000297)
- Craddock, N. J. et al. 1997. Expanded CAG/CTG repeats in bipolar disorder: no correlation with phenotypic measures of illness severity. Biological psychiatry 42(10), pp. 876-881. (10.1016/s0006-3223(96)00516-1)
- Guy, C. et al. 1997. Exclusion of expansion of 50 CAG/CTG trinucleotide repeats in bipolar disorder. American Journal of Psychiatry 154(8), pp. 1146-1147.
- Speight, G. et al. 1997. Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia. American Journal of Medical Genetics 74(2), pp. 204-206. (10.1002/(SICI)1096-8628(19970418)74:2<204::AID-AJMG19>3.0.CO;2-M)
- O'Donovan, M. C. and Guy, C. 1997. Bias in the genomic distribution of CAG and CTG trinucleotide repeats. American Journal of Medical Genetics 74(1), pp. 62-64. (10.1002/(SICI)1096-8628(19970221)74:1<62::AID-AJMG14>3.0.CO;2-P)
- Craddock, N. J., O'Donovan, M. C. and Owen, M. J. 1996. Introducing Selfcite 2.0--career enhancing software. BMJ 313(7072), pp. 1659-1660. (10.1136/bmj.313.7072.1659)
- Cardno, A. G. et al. 1996. Expanded CAG/CTG repeats in schizophrenia. A study of clinical correlates. British Journal of Psychiatry 169(6), pp. 766-771. (10.1192/bjp.169.6.766)
- O'Donovan, M. C., Craddock, N. J., Guy, C., McGuffin, P. and Owen, M. J. 1996. Involvement of expanded trinucleotide repeats in common diseases. The Lancet 348(9043), pp. 1739-1740. (10.1016/s0140-6736(05)65870-9)
- O'Donovan, M. C. et al. 1996. Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychological Medicine -London- 26(6), pp. 1145-1153. (10.1017/s0033291700035868)
- Bowen, T. et al. 1996. Expansion of 50 CAG/CTG repeats excluded in schizophrenia by application of a highly efficient approach using repeat expansion detection and a PCR screening set. American Journal of Human Genetics 59(4), pp. 912-917.
- O'Donovan, M. C. 1996. Genetics of Mental disorders .1. Theoretical aspects - Mendlewicz,J, Papadimitriou,GN. British Journal of Psychiatry 168(2), pp. 256-256.
- O'Donovan, M. C. and Owen, M. J. 1996. Dynamic mutations and psychiatric genetics. Psychological Medicine 26(1), pp. 1-6. (10.1017/S0033291700033663)
- O'Donovan, M. C. et al. 1995. Expanded CAG repeats in schizophrenia and bipolar disorder [letter]. Nature Genetics 10(4), pp. 380-381. (10.1038/ng0895-380)
- Thapar, A., Gottesman, I. I., Owen, M. J., O'Donovan, M. C. and McGuffin, P. 1994. The genetics of mental retardation. The British Journal of Psychiatry 164(6), pp. 747. (10.1192/bjp.164.6.747)
- Spurlock, G., Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1994. Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter. Neuropharmacology 33(3-4), pp. 433-440. (10.1016/0028-3908(94)90073-6)
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1993. Clozapine and sulpiride up-regulate dopamine D3 receptor mRNA levels. Neuropharmacology 32(9), pp. 901-907. (10.1016/0028-3908(93)90146-T)
- McGuffin, P. and O'Donovan, M. C. 1993. Taking a balanced view on triazolam. British Medical Journal (BMJ) 306(6893), pp. 1690-1691. (10.1136/bmj.306.6893.1690-c)
- O'Donovan, M. C. and McGuffin, P. 1993. Correction: Short acting benzodiazepines. British Medical Journal (BMJ) 306(6886), pp. 1146-1146. (10.1136/bmj.306.6886.1146)
- O'Donovan, M. C. and McGuffin, P. 1993. Short acting benzodiazepines.. British Medical Journal (BMJ) 306(6883), pp. 945-946. (10.1136/bmj.306.6883.945)
- O'Donovan, M. C. 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72(6), pp. 971-983. (10.1016/0092-8674(93)90585-E)
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1993. Both splicing variants of the dopamine D2 receptor mRNA are up-regulated by antipsychotic drugs. Neuroscience Letters 150(1), pp. 25-28. (10.1016/0304-3940(93)90099-7)
- O'Donovan, M. C., Buckland, P. R., Spurlock, G. and McGuffin, P. 1992. Bi-directional changes in the levels of messenger RNAs encoding γ-aminobutyric acidA receptor α subunits after flurazepam treatment. European Journal of Pharmacology: Molecular Pharmacology 226(4), pp. 335-341. (10.1016/0922-4106(92)90051-V)
- O'Donovan, M. C. and Owen, M. J. 1992. Advances and Retreats in the Molecular Genetics of Major Mental Illness. Annals of Medicine 24(3), pp. 171-177. (10.3109/07853899209147816)
- O'Donovan, M. C., Buckland, P. R. and McGuffin, P. 1992. Levels of GABAa receptor subunit mRNA in rat brain following flurazepam treatment. Journal of Psychopharmacology 6(3), pp. 364-369. (10.1177/026988119200600304)
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1992. Changes in dopamine D1, D2 and D3 receptor mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 106(4), pp. 479-483. (10.1007/BF02244818)
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1992. Changes in dopa decarboxylase mRNA but not tyrosine hydroxylase mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology 108(1-2), pp. 98-102. (10.1007/BF02245292)
- Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1992. Lack of effect of chronic antipsychotic treatment on dopamine D5 receptor mRNA level. European Neuropsychopharmacology 2(4), pp. 405-409. (10.1016/0924-977X(92)90002-P)
- O'Donovan, M. C., Buckland, P. R. and McGuffin, P. 1992. The expression of neuroreceptor genes and benzodiazepine tolerance.. Clinical Neuropharmacology 15(Supp1), pp. 218A-219A. (10.1097/00002826-199201001-00114)
- O'Donovan, M. C. and McGuffin, P. 1991. Growing points in psychiatric genetics. British Journal of Hospital Medicine 46(6), pp. 359-360.
- Havard, H. L., Buckland, P. R., O'Donovan, M. C. and McGuffin, P. 1991. The effects of antidepressant drugs on kainate receptor mRNA levels. Neuropharmacology 30(6), pp. 675-677. (10.1016/0028-3908(91)90090-X)
- O'Donovan, M. C. and Buckland, P. R. 1991. Simultaneous quantification of several mRNA species by solution hybridisation with oligonucleotides. Nucleic Acids Research 19(12), pp. 3466. (10.1093/nar/19.12.3466)
- Espie, C., Pashley, A., Bonham, K., Sourindhrin, I. and O'Donovan, M. C. 1989. The mentally handicapped person with epilepsy: a comparative study investigating psychosocial functioning.. Journal of Mental Health Defiency Research 33(2), pp. 123-135.
Book sections
- O'Donovan, M. C. and Owen, M. J. 2003. Genetic findings in psychotic disorders. In: Soares, J. C. and Gershon, S. eds. Handbook of Medical Psychiatry. New York: Marcel Dekker, pp. 417-432.
- Owen, M. J. and O'Donovan, M. C. 2003. Schizophrenia and genetics. In: Plomin, R. et al. eds. Behavioral Genetics in the Postgenomic Era. Washington, DC: APA Books, pp. 463-480., (10.1037/10480-023)
- Zammit, S., O'Donovan, M. C. and Owen, M. J. 2002. Neurogenetics of schizophrenia. In: D'haenen, H., den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley, pp. 663-671., (10.1002/0470854871.chxvii9)
- Thapar, A. and O'Donovan, M. C. 2002. Neurogenetics. In: D'haenen, H., den Boer, J. A. and Willner, P. eds. Biological Psychiatry. Chichester: Wiley, pp. 167-180., (10.1002/0470854871.chxii)
Books
- McGuffin, P., Owen, M. J., O'Donovan, M. C., Thapar, A. and Gottesman, I. I. 1994. Seminars in psychiatric genetics. Gaskell, Royal College of Psychiatrists.
Websites
- Crawford, K. et al. 2022. Analysis of Alzheimer's disease Polygenic Risk Scores using RNA-sequencing provides further novel biological pathways. [Online]. medRxiv: Cold Spring Harbor Laboratory. (10.1101/2022.06.29.22276952) Available at: https://doi.org/10.1101/2022.06.29.22276952
- O'Brien, H. et al. 2019. Sex differences in gene expression in the human fetal brain. [Online]. bioRxiv. (10.1101/483636) Available at: https://doi.org/10.1101/483636
- Sims, R. et al. 2018. Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing. [Online]. bioRxiv. (10.1101/294629) Available at: https://doi.org/10.1101/294629
- Pardinas, A. et al. 2016. Common schizophrenia alleles are enriched in mutation-intolerant genes and maintained by background selection. [Online]. bioRxiv. (10.1101/068593) Available at: http://dx.doi.org/10.1101/068593
Research
After obtaining my undergraduate qualifications in Physiology (BSc) and Medicine (MBChB) at the University of Glasgow, I specialized in psychiatry. I began my research career in 1989 as an MRC Training Fellow when I developed novel methods for quantitating mRNA, used these to show alterations in the relative expression of genes encoding subunits of GABAA receptors was a mechanism that contributes the biology of benzodiazepine tolerance, and obtained a PhD in Molecular Pharmacology.
1992-1993, I was an MRC Travelling Fellow at the laboratory of David Housman at MIT where I was a member of The Huntington's Disease Collaborative Research Group.
In 1993, I was appointed Senior Lecturer in the Department of Psychological Medicine, University of Wales College of Medicine, and was awarded a personal chair in Psychiatric Genetics in 1999. I have a broad interest in the molecular genetics and neurobiology of mental disorders and have held grants from many major funding bodies (MRC, Wellcome Trust, National Institute of Mental Health (USA), European Union) for molecular genetic studies of schizophrenia, bipolar disorder, dyslexia, ADHD, and Alzheimer's disease. I am currently the Chair of the Schizophrenia Working Group of the Psychiatric Genomics Consortium.
Biography
- Professor of Psychiatric Genetics, MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK
- Senior Lecturer in Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales; (Sept 1993-April 1999)
- Medical Research Council Travelling Fellow, Center for Cancer Research, Building E17/536, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge 02139-4307, USA; (September 1992 - August 1993)
- Medical Research Council Training Fellow, Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales; (September 1989 - August 1992)
- Lecturer in Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales; (March 1988 - August 1989).
Contact Details
ODonovanMC@cardiff.ac.uk
+44 29206 88323
Hadyn Ellis Building, Room 3.02, Maindy Road, Cardiff, CF24 4HQ
+44 29206 88323
Hadyn Ellis Building, Room 3.02, Maindy Road, Cardiff, CF24 4HQ
