Dr Polina Prokopovich
(she/her)
Teams and roles for Polina Prokopovich
Reader in HealthCare Technologies
Overview
I lead a multidisciplinary research group conducting a range of methodologies in drug and formulation development and scale-up, medical device fabrication through preclinical and early phase clinical testing.
Another arm of my research is focused on real-world evidence (RWE) conducting large dataset analysis and employing machine learning algorithms to answer specific clinically relevant questions through predictive modelling.
My portfolio of research covers infectious, autoimmune, musculoskeletal diseases and cancer.
Publication
2025
- Gambrill, B. et al. 2025. A novel multilayer antimicrobial urinary catheter material with antimicrobial properties. Materials Advances 6 , pp.1020-1030. (10.1039/d4ma01045k)
- Perni, S. , Subburaman, S. and Prokopovich, P. 2025. Early cost-effectiveness analysis of intra-articular delivery of a PBAE-DEX conjugate for osteoarthritis in a UK population. Clinical Drug Investigation (10.1007/s40261-025-01446-7)
2024
- Alghamdi, R. , Pertusati, F. and Prokopovich, P. 2024. Poly-beta-amino-ester licofelone conjugates development for osteoarthritis treatment †. RSC Advances 14 (1), pp.15-28. (10.1039/d3ra04967a)
- Gambrill, B. et al. 2024. Materials-based incidence of urinary catheter associated urinary tract infections and the causative micro-organisms: systematic review and meta-analysis. BMC Urology 24 (1) 186. (10.1186/s12894-024-01565-x)
- Pavanello, L. et al., 2024. Physicochemical and biological properties of dental materials and formulations with silica nanoparticles: A narrative review. Dental Materials 40 (11), pp.1729-1741. (10.1016/j.dental.2024.07.028)
- Perni, S. and Prokopovich, P. 2024. Risk equations for prosthetic joint infections (PJIs) in UK: a retrospective study using the Clinical Practice Research Datalink (CPRD) AURUM and GOLD databases. BMJ Open 14 (5) e082501. (10.1136/bmjopen-2023-082501)
- Saeedi, T. and Prokopovich, P. 2024. Screening of poly-beta amino ester coated emulsion of ketorolac for cartilage delivery †. Journal of Materials Chemistry B: Materials for biology and medicine 12 (24), pp.5930-5939. (10.1039/d4tb00313f)
2023
- Larissa, P. et al., 2023. Development, characterization and antimicrobial activity of multilayer silica nanoparticles with chlorhexidine incorporated into dental composites. Dental Materials 39 (5), pp.469-477. (10.1016/j.dental.2023.03.005)
- Li, Z. et al., 2023. Low‐field actuating magnetic elastomer membranes characterized using fibre‐optic interferometry. Advanced Functional Materials 33 (50) 2301857. (10.1002/adfm.202301857)
- Perni, S. , Bojan, B. and Prokopovich, P. 2023. A retrospective study of risk factors, causative micro-organisms and healthcare resources consumption associated with prosthetic joint infections (PJI) using the Clinical Practice Research Datalink (CPRD) Aurum database. PLoS ONE 18 (3) e0282709. (10.1371/journal.pone.0282709)
- Yang, L. et al. 2023. Nanocomposite orthopaedic bone cement combining long-acting dual antimicrobial drugs. Biomaterials Advances 153 213538. (10.1016/j.bioadv.2023.213538)
2022
- Assylbekova, G. et al., 2022. Sunlight induced synthesis of silver nanoparticles on cellulose for the preparation of antimicrobial textiles. Journal of Photochemistry and Photobiology 11 100134. (10.1016/j.jpap.2022.100134)
- Perni, S. and Prokopovich, P. 2022. Feasibility and application of machine learning enabled fast screening of poly-beta-amino-esters for cartilage therapies. Scientific Reports 12 (1) 14215. (10.1038/s41598-022-18332-3)
2021
- Al Thaher, Y. et al. 2021. PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers. PLoS ONE 16 (9) e0257947. (10.1371/journal.pone.0257947)
- Perni, S. , Preedy, E. C. and Prokopovich, P. 2021. Amplify antimicrobial photo dynamic therapy efficacy with poly-beta-amino esters (PBAEs). Scientific Reports 11 (1) 7275. (10.1038/s41598-021-86773-3)
- Saeedi, T. and Prokopovich, P. 2021. Poly beta amino ester coated emulsions of NSAIDs for cartilage treatment. Journal of Materials Chemistry B: Materials for biology and medicine 9 (29), pp.5837-5847. (10.1039/D1TB01024G)
2020
- Bojan, B. , Perni, S. and Prokopovich, P. 2020. Systematic review and meta-analysis of tobacco use as a risk factor for prosthetic joint infection after total hip replacement. Arthroplasty Today 6 (4), pp.959-971. (10.1016/j.artd.2020.07.011)
- Perni, S. et al. 2020. Long acting anti-infection constructs on titanium. Journal of Controlled Release 326 , pp.91-105. (10.1016/j.jconrel.2020.06.013)
- Perni, S. and Prokopovich, P. 2020. Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage. Journal of Materials Chemistry. B 8 (23), pp.5096-5108. (10.1039/C9TB02778E)
- Perni, S. and Prokopovich, P. 2020. Rheometer enabled study of cartilage frequency-dependent properties. Scientific Reports 10 (1) 20696. (10.1038/s41598-020-77758-9)
- Saeedi, T. , Alotaibi, H. F. and Prokopovich, P. 2020. Polymer colloids as drug delivery systems for the treatment of arthritis. Advances in Colloid and Interface Science 285 102273. (10.1016/j.cis.2020.102273)
2019
- Alotaibi, H. F. , Perni, S. and Prokopovich, P. 2019. Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention. International Journal of Nanomedicine 2019 (14), pp.7309. (10.2147/IJN.S217112)
- Perni, S. et al. 2019. Prolonged antimicrobial activity of PMMA bone cement with embedded gentamicin-releasing silica nanocarriers. ACS Applied Bio Materials 2 (5), pp.1850-1861. (10.1021/acsabm.8b00752)
- Rivera, M. et al., 2019. Anti-inflammatory drug-eluting implant model system to prevent wear particles induced periprosthetic osteolysis. International Journal of Nanomedicine 14 , pp.1069-1084. (10.2147/IJN.S188193)
2018
- Al Thaher, Y. et al. 2018. Role of poly-beta-amino-esters hydrolysis and electrostatic attraction in Gentamicin release from Layer-by-Layer coatings. Journal of Colloid and Interface Science 526 , pp.35-42. (10.1016/j.jcis.2018.04.042)
- Al Thaher, Y. et al. 2018. LbL-assembled gentamicin delivery system for PMMA bone cements to prolong antimicrobial activity. PLoS ONE 13 (12) e0207753. (10.1371/journal.pone.0207753)
- Alotaibi, H. F. et al., 2018. Role of processing parameters on surface and wetting properties controlling the behaviour of layer-by-layer coated nanoparticles. Current Opinion in Colloid and Interface Science 36 , pp.130-142. (10.1016/j.cocis.2018.02.008)
- Perni, S. , Martini-Gilching, K. and Prokopovich, P. 2018. Controlling release kinetics of gentamicin from silica nano-carriers. Colloids and Surfaces A: Physicochemical and Engineering Aspects 541 , pp.212-221. (10.1016/j.colsurfa.2017.04.063)
- Perni, S. et al. 2018. Cobalt and Titanium nanoparticles influence on human osteoblast mitochondrial activity and biophysical properties of their cytoskeleton. Journal of Colloid and Interface Science 531 , pp.410-420. (10.1016/j.jcis.2018.07.028)
2017
- Abdurazova, P. et al., 2017. Preparation of photochemical coatings of metal films (copper, silver and gold) on dielectric surfaces and studying their antimicrobial properties. Colloids and Surfaces A: Physicochemical and Engineering Aspects 532 , pp.63-69. (10.1016/j.colsurfa.2017.06.070)
- Al Thaher, Y. , Perni, S. and Prokopovich, P. 2017. Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material. Advances in Colloid and Interface Science 249 , pp.234-247. (10.1016/j.cis.2017.04.017)
- Perni, S. and Prokopovich, P. 2017. Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage. Nanomedicine: Nanotechnology, Biology and Medicine 13 (2), pp.539-548. (10.1016/j.nano.2016.10.001)
- Preedy, E. C. , Perni, S. and Prokopovich, P. 2017. Cobalt and titanium nanoparticles influence on mesenchymal stem cell elasticity and turgidity. Colloids and Surfaces B: Biointerfaces 157 , pp.146-156. (10.1016/j.colsurfb.2017.05.019)
- Sataev, M. S. et al., 2017. A low-temperature gold coating of the dielectric surfaces employing phosphine gas as a reducing agent. Colloids and Surfaces A: Physicochemical and Engineering Aspects 521 , pp.86-91. (10.1016/j.colsurfa.2016.11.029)
2016
- Giacomo, T. , Perni, S. and Prokopovich, P. 2016. An injectable hydrogel as bone graft material with added antimicrobial properties. Tissue Engineering: Parts A, B, and C 22 (11-12), pp.862-872. (10.1089/ten.tea.2016.0014)
- Perni, S. et al. 2016. Lethal photosensitisation of bacteria using Silica-TBO nanoconjugates. Colloids and Surfaces A: Physicochemical and Engineering Aspects 510 , pp.293-299. (10.1016/j.colsurfa.2016.06.022)
- Perni, S. et al. 2016. Influence of csgD and ompR on nanomechanics, adhesion forces and curli properties of E. coli. Langmuir 32 (31), pp.7965-7974. (10.1021/acs.langmuir.6b02342)
- Preedy, E. C. , Perni, S. and Prokopovich, P. 2016. Nanomechanical and surface properties of rMSCs post exposure to CAP treated UHMWPE wear particles. Nanomedicine: Nanotechnology, Biology and Medicine 12 (3), pp.723-734. (10.1016/j.nano.2015.10.006)
2015
- González-Sánchez, M. I. et al., 2015. Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications. Materials Science and Engineering C 50 , pp.332-340. (10.1016/j.msec.2015.02.002)
- Gustaite, S. et al., 2015. Characterization of cellulose based sponges for wound dressings. Colloids and Surfaces A: Physicochemical and Engineering Aspects 480 , pp.336-342. (10.1016/j.colsurfa.2014.08.022)
- Perni, S. and Prokopovich, P. 2015. Multi-asperity elliptical JKR model for adhesion of a surface with non-axially symmetric asperities. Tribology International 88 , pp.107-114. (10.1016/j.triboint.2015.03.001)
- Perni, S. et al. 2015. Antimicrobial activity of bone cements embedded with organic nanoparticles. International Journal of Nanomedicine 10 , pp.6317-6329. (10.2147/IJN.S86440)
- Preedy, E. C. , Perni, S. and Prokopovich, P. 2015. Cobalt, titanium and PMMA bone cement debris influence on mouse osteoblast cell elasticity, spring constant and calcium production activity. RSC Advances 5 , pp.83885-83898. (10.1039/C5RA15390E)
- Prokopovich, P. et al. 2015. Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid. Journal of Biomedical Materials Research: Part B - Applied Biomaterials 103 (2), pp.273-281. (10.1002/jbm.b.33196)
- Sataev, M. S. et al., 2015. A galvanic-chemical method for preparing diamond containing coatings. Colloids and Surfaces A: Physicochemical and Engineering Aspects 480 , pp.384-389. (10.1016/j.colsurfa.2014.09.014)
2014
- Omar, F. et al. 2014. Development and experimental validation of an analytical model to predict the demoulding force in hot embossing. Journal of Micromechanics and Microengineering 24 (5), pp.-. 055007. (10.1088/0960-1317/24/5/055007)
- Pandiyaraj, K. N. et al., 2014. Influence of operating parameters on surface properties of RF glow discharge oxygen plasma treated TiO2/PET film for biomedical application. Materials Science and Engineering C 36 , pp.309-319. (10.1016/j.msec.2013.12.018)
- Perni, S. , Hakala, V. and Prokopovich, P. 2014. Biogenic synthesis of antimicrobial silver nanoparticles capped with L-cysteine. Colloids and Surfaces A: Physicochemical and Engineering Aspects 460 , pp.219-224. (10.1016/j.colsurfa.2013.09.034)
- Perni, S. , Preedy, E. C. and Prokopovich, P. 2014. Success and failure of colloidal approaches in adhesion of microorganisms to surfaces. Advances in Colloid and Interface Science 206 , pp.265-274. (10.1016/j.cis.2013.11.008)
- Perni, S. and Prokopovich, P. 2014. Continuous release of gentamicin from gold nanocarrier. RSC Advances 4 (94), pp.51904-51910. (10.1039/C4RA10023A)
- Preedy, E. C. et al. 2014. Adhesive forces and surface properties of cold gas plasma treated UHMWPE. Colloids and Surfaces A: Physicochemical and Engineering Aspects 460 , pp.83-89. (10.1016/j.colsurfa.2014.03.052)
- Preedy, E. C. et al. 2014. Surface roughness mediated adhesion forces between borosilicate glass and gram-positive bacteria. Langmuir 30 (31), pp.9466-9476. (10.1021/la501711t)
- Prokopovich, P. 2014. Interactions between mammalian cells and nano- or micro-sized wear particles: Physico-chemical views against biological approaches. Advances in Colloid and Interface Science 213 , pp.36-47. (10.1016/j.cis.2014.09.001)
- Ramadan, Y. et al., 2014. Obtaining new composite biomaterials by means of mineralization of methacrylate hydrogels using the reaction-diffusion method. Materials Science and Engineering C 42 , pp.696-704. (10.1016/j.msec.2014.06.017)
- Sataev, M. S. et al., 2014. Novel process for coating textile materials with silver to prepare antimicrobial fabrics. Colloids and Surfaces A: Physicochemical and Engineering Aspects 442 , pp.146-151. (10.1016/j.colsurfa.2013.02.018)
2013
- Khan, I. M. et al. 2013. In vitro growth factor-induced bio engineering of mature articular cartilage. Biomaterials 34 (5), pp.1478-1487. (10.1016/j.biomaterials.2012.09.076)
- Omar, F. et al. 2013. Demoulding forces in hot embossing: Model development and validation. Presented at: 8th International Conference on MicroManufacturing (ICOMM2013) Victoria, Canada 25-28 March 2013. Proceedings of the 8th International Conference on MicroManufacturing (ICOMM2013). , pp.642-649.
- Perni, S. and Prokopovich, P. 2013. Micropatterning with conical features can control bacterial adhesion on silicone. Soft Matter 9 (6), pp.1844-1851. (10.1039/c2sm26828k)
- Prokopovich, P. et al. 2013. A novel bone cement impregnated with silver-tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties. International Journal of Nanomedicine 8 (1), pp.2227-2237. (10.2147/IJN.S42822)
- Prokopovich, P. and Perni, S. 2013. Contact interactions of aorta against PVC catheters. Tribology International 66 , pp.157-164. (10.1016/j.triboint.2013.03.009)
2012
- Noimark, S. et al., 2012. Incorporation of methylene blue and nanogold into polyvinyl chloride catheters; a new approach for light-activated disinfection of surfaces. Journal of Materials Chemistry 22 (30), pp.15388-15396. (10.1039/C2JM31987J)
- Perni, S. , Kong, M. G. and Prokopovich, P. 2012. Cold atmospheric pressure gas plasma enhances the wear performance of ultra-high molecular weight polyethylene. Acta Biomaterialia 8 (3), pp.1357-1365. (10.1016/j.actbio.2011.12.007)
- Prokopovich, P. 2012. A dimensionless analysis of the effect of material and surface properties on adhesion. applications to medical device design. In: Starov, V. and Griffiths, P. eds. Progress in Colloid and Polymer Sceinve. Vol. 139, Springer Verlag. , pp.59-65. (10.1007/978-3-642-28974-3_11)
- Vicars, R. et al., 2012. The Effect of Anterior-Posterior Shear on the Wear of Charité TDR. Spine 37 (9), pp.E528-E534. (10.1097/BRS.0b013e31823cbd6e)
2011
- Perni, S. et al., 2011. Antimicrobial Properties of Light-activated Polyurethane Containing Indocyanine Green. Journal of Biomaterials Applications 25 (5), pp.387-400. (10.1177/0885328209352701)
- Perni, S. et al., 2011. Nanoparticles: their potential use in antibacterial photodynamic therapy. Photochemical and Photobiological Sciences 10 (5), pp.712-720. (10.1039/C0PP00360C)
- Prokopovich, P. and Perni, S. 2011. Comparison of JKR- and DMT-based multi-asperity adhesion model: Theory and experiment. Colloids and Surfaces A: Physicochemical and Engineering Aspects 383 (1-3), pp.95-101. (10.1016/j.colsurfa.2011.01.011)
- Prokopovich, P. et al. 2011. Spatial variation of wear on Charité lumbar discs. Acta Biomaterialia 7 (11), pp.3914-3926. (10.1016/j.actbio.2011.06.036)
- Prokopovich, P. and Starov, V. 2011. Adhesion models: From single to multiple asperity contacts. Advances in Colloid and Interface Science 168 (1-2), pp.210-222. (10.1016/j.cis.2011.03.004)
2010
- Perni, S. et al., 2010. Prevention of biofilm accumulation on a light-activated antimicrobial catheter material. Journal of Materials Chemistry 20 (39), pp.8668-8673. (10.1039/C0JM01891K)
- Prokopovich, P. and Perni, S. 2010. Prediction of the frictional behavior of mammalian tissues against biomaterials. Acta Biomaterialia 6 (10), pp.4052-4059. (10.1016/j.actbio.2010.05.007)
- Prokopovich, P. et al. 2010. Frictional Properties of Light-activated Silicone and Polyurethane against blood vessels. Journal of Materials Science: Materials in Medicine 21 (2), pp.815-821. (10.1007/s10856-009-3882-2)
- Prokopovich, P. and Perni, S. 2010. Multiasperity contact adhesion model for universal asperity height and radius of curvature distributions. Langmuir 26 (22), pp.17028-17036. (10.1021/la102208y)
- Prokopovich, P. et al. 2010. Friction in ultra-thin conjunction of valve seals of pressurised metered dose inhalers. Wear 268 (5-6), pp.845-852. (10.1016/j.wear.2009.12.003)
- Prokopovich, P. et al. 2010. Nano- and component level friction of rubber seals in dispensing devices. Presented at: ASME International Design Engineering Technical Conferences and Computers and Information in Engineering Conference San Diego, CA, USA 30 August-2 September 2009. ASME Power Transmission and Gearing Conference; 3rd International Conference on Micro- and Nanosystems; 11th International Conference on Advanced Vehicle and Tire Technologies. ASME Conference Proceedings Vol. 6. New York: ASME. , pp.339-344. (10.1115/DETC2009-86035)
2009
- Perni, S. et al., 2009. The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles. Biomaterials 30 (1), pp.89-93. (10.1016/j.biomaterials.2008.09.020)
- Perni, S. et al., 2009. Toluidine blue-containing polymers exhibit potent bactericidal activity when irradiated with red laser light. Journal of Materials Chemistry 19 (18), pp.2715-2723. (10.1039/B820561B)
- Piccirillo, C. et al., 2009. Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface. Journal of Materials Chemistry 19 (34), pp.6167-6171. (10.1039/b905495b)
- Prokopovich, P. and Perni, S. 2009. An investigation of microbial adhesion to natural and synthetic polysaccharide-based films and its relationship with the surface energy components. Journal of Materials Science: Materials in Medicine 20 (1), pp.195-202. (10.1007/s10856-008-3555-6)
2007
- Dmitrieva, I. B. et al., 2007. Investigation of the electrosurface properties of NiO and Fe2O3 in azole solutions. Colloids and Surfaces A: Physicochemical and Engineering Aspects 300 (3), pp.315-320. (10.1016/j.colsurfa.2007.01.046)
2006
- Holdich, R. et al., 2006. Spreading of liquid drops from a liquid source. Colloids and Surfaces A: Physicochemical and Engineering Aspects 282-83 , pp.247-255. (10.1016/j.colsurfa.2005.11.023)
- Prokopovich, P. et al. 2006. Concentration of potassium cations in the permeate solution in the presence of N,N-dimethyl-N-2-propenyl-2-propen-1-aminium chloride homopolymer using dead-end nano-or ultrafiltration. Colloid Journal c/c of Kolloidnyi Zhurnal 68 (2), pp.211-216. (10.1134/S1061933X0602013X)
2005
- Churaev, N. V. et al., 2005. Reversible adsorption inside pores of ultrafiltration membranes. Journal of Colloid and Interface Science 288 (1), pp.205-212. (10.1016/j.jcis.2005.02.072)
- Prokopovich, P. , Starov, V. and Holdich, R. G. 2005. Concentration of inorganic salts in the permeate during nano- or ultrafiltration promoted by water-soluble polyelectrolytes in the feed solution. Industrial & Engineering Chemistry Research 44 (5), pp.1358-1369. (10.1021/ie049696l)
2004
- Dmitrieva, I. B. et al., 2004. Specific adsorption of barbituric acid on ferric(III) and nickel(II) oxides. Colloids and Surfaces A: Physicochemical and Engineering Aspects 239 (1-3), pp.19-24. (10.1016/j.colsurfa.2003.12.033)
Articles
- Abdurazova, P. et al., 2017. Preparation of photochemical coatings of metal films (copper, silver and gold) on dielectric surfaces and studying their antimicrobial properties. Colloids and Surfaces A: Physicochemical and Engineering Aspects 532 , pp.63-69. (10.1016/j.colsurfa.2017.06.070)
- Al Thaher, Y. et al. 2021. PMMA bone cement containing long releasing silica-based chlorhexidine nanocarriers. PLoS ONE 16 (9) e0257947. (10.1371/journal.pone.0257947)
- Al Thaher, Y. et al. 2018. Role of poly-beta-amino-esters hydrolysis and electrostatic attraction in Gentamicin release from Layer-by-Layer coatings. Journal of Colloid and Interface Science 526 , pp.35-42. (10.1016/j.jcis.2018.04.042)
- Al Thaher, Y. , Perni, S. and Prokopovich, P. 2017. Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material. Advances in Colloid and Interface Science 249 , pp.234-247. (10.1016/j.cis.2017.04.017)
- Al Thaher, Y. et al. 2018. LbL-assembled gentamicin delivery system for PMMA bone cements to prolong antimicrobial activity. PLoS ONE 13 (12) e0207753. (10.1371/journal.pone.0207753)
- Alghamdi, R. , Pertusati, F. and Prokopovich, P. 2024. Poly-beta-amino-ester licofelone conjugates development for osteoarthritis treatment †. RSC Advances 14 (1), pp.15-28. (10.1039/d3ra04967a)
- Alotaibi, H. F. et al., 2018. Role of processing parameters on surface and wetting properties controlling the behaviour of layer-by-layer coated nanoparticles. Current Opinion in Colloid and Interface Science 36 , pp.130-142. (10.1016/j.cocis.2018.02.008)
- Alotaibi, H. F. , Perni, S. and Prokopovich, P. 2019. Nanoparticle-based model of anti-inflammatory drug releasing LbL coatings for uncemented prosthesis aseptic loosening prevention. International Journal of Nanomedicine 2019 (14), pp.7309. (10.2147/IJN.S217112)
- Assylbekova, G. et al., 2022. Sunlight induced synthesis of silver nanoparticles on cellulose for the preparation of antimicrobial textiles. Journal of Photochemistry and Photobiology 11 100134. (10.1016/j.jpap.2022.100134)
- Bojan, B. , Perni, S. and Prokopovich, P. 2020. Systematic review and meta-analysis of tobacco use as a risk factor for prosthetic joint infection after total hip replacement. Arthroplasty Today 6 (4), pp.959-971. (10.1016/j.artd.2020.07.011)
- Churaev, N. V. et al., 2005. Reversible adsorption inside pores of ultrafiltration membranes. Journal of Colloid and Interface Science 288 (1), pp.205-212. (10.1016/j.jcis.2005.02.072)
- Dmitrieva, I. B. et al., 2004. Specific adsorption of barbituric acid on ferric(III) and nickel(II) oxides. Colloids and Surfaces A: Physicochemical and Engineering Aspects 239 (1-3), pp.19-24. (10.1016/j.colsurfa.2003.12.033)
- Dmitrieva, I. B. et al., 2007. Investigation of the electrosurface properties of NiO and Fe2O3 in azole solutions. Colloids and Surfaces A: Physicochemical and Engineering Aspects 300 (3), pp.315-320. (10.1016/j.colsurfa.2007.01.046)
- Gambrill, B. et al. 2024. Materials-based incidence of urinary catheter associated urinary tract infections and the causative micro-organisms: systematic review and meta-analysis. BMC Urology 24 (1) 186. (10.1186/s12894-024-01565-x)
- Gambrill, B. et al. 2025. A novel multilayer antimicrobial urinary catheter material with antimicrobial properties. Materials Advances 6 , pp.1020-1030. (10.1039/d4ma01045k)
- Giacomo, T. , Perni, S. and Prokopovich, P. 2016. An injectable hydrogel as bone graft material with added antimicrobial properties. Tissue Engineering: Parts A, B, and C 22 (11-12), pp.862-872. (10.1089/ten.tea.2016.0014)
- González-Sánchez, M. I. et al., 2015. Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications. Materials Science and Engineering C 50 , pp.332-340. (10.1016/j.msec.2015.02.002)
- Gustaite, S. et al., 2015. Characterization of cellulose based sponges for wound dressings. Colloids and Surfaces A: Physicochemical and Engineering Aspects 480 , pp.336-342. (10.1016/j.colsurfa.2014.08.022)
- Holdich, R. et al., 2006. Spreading of liquid drops from a liquid source. Colloids and Surfaces A: Physicochemical and Engineering Aspects 282-83 , pp.247-255. (10.1016/j.colsurfa.2005.11.023)
- Khan, I. M. et al. 2013. In vitro growth factor-induced bio engineering of mature articular cartilage. Biomaterials 34 (5), pp.1478-1487. (10.1016/j.biomaterials.2012.09.076)
- Larissa, P. et al., 2023. Development, characterization and antimicrobial activity of multilayer silica nanoparticles with chlorhexidine incorporated into dental composites. Dental Materials 39 (5), pp.469-477. (10.1016/j.dental.2023.03.005)
- Li, Z. et al., 2023. Low‐field actuating magnetic elastomer membranes characterized using fibre‐optic interferometry. Advanced Functional Materials 33 (50) 2301857. (10.1002/adfm.202301857)
- Noimark, S. et al., 2012. Incorporation of methylene blue and nanogold into polyvinyl chloride catheters; a new approach for light-activated disinfection of surfaces. Journal of Materials Chemistry 22 (30), pp.15388-15396. (10.1039/C2JM31987J)
- Omar, F. et al. 2014. Development and experimental validation of an analytical model to predict the demoulding force in hot embossing. Journal of Micromechanics and Microengineering 24 (5), pp.-. 055007. (10.1088/0960-1317/24/5/055007)
- Pandiyaraj, K. N. et al., 2014. Influence of operating parameters on surface properties of RF glow discharge oxygen plasma treated TiO2/PET film for biomedical application. Materials Science and Engineering C 36 , pp.309-319. (10.1016/j.msec.2013.12.018)
- Pavanello, L. et al., 2024. Physicochemical and biological properties of dental materials and formulations with silica nanoparticles: A narrative review. Dental Materials 40 (11), pp.1729-1741. (10.1016/j.dental.2024.07.028)
- Perni, S. et al., 2009. The antimicrobial properties of light-activated polymers containing methylene blue and gold nanoparticles. Biomaterials 30 (1), pp.89-93. (10.1016/j.biomaterials.2008.09.020)
- Perni, S. et al., 2011. Antimicrobial Properties of Light-activated Polyurethane Containing Indocyanine Green. Journal of Biomaterials Applications 25 (5), pp.387-400. (10.1177/0885328209352701)
- Perni, S. et al., 2011. Nanoparticles: their potential use in antibacterial photodynamic therapy. Photochemical and Photobiological Sciences 10 (5), pp.712-720. (10.1039/C0PP00360C)
- Perni, S. et al. 2020. Long acting anti-infection constructs on titanium. Journal of Controlled Release 326 , pp.91-105. (10.1016/j.jconrel.2020.06.013)
- Perni, S. , Bojan, B. and Prokopovich, P. 2023. A retrospective study of risk factors, causative micro-organisms and healthcare resources consumption associated with prosthetic joint infections (PJI) using the Clinical Practice Research Datalink (CPRD) Aurum database. PLoS ONE 18 (3) e0282709. (10.1371/journal.pone.0282709)
- Perni, S. et al. 2019. Prolonged antimicrobial activity of PMMA bone cement with embedded gentamicin-releasing silica nanocarriers. ACS Applied Bio Materials 2 (5), pp.1850-1861. (10.1021/acsabm.8b00752)
- Perni, S. et al. 2016. Lethal photosensitisation of bacteria using Silica-TBO nanoconjugates. Colloids and Surfaces A: Physicochemical and Engineering Aspects 510 , pp.293-299. (10.1016/j.colsurfa.2016.06.022)
- Perni, S. , Hakala, V. and Prokopovich, P. 2014. Biogenic synthesis of antimicrobial silver nanoparticles capped with L-cysteine. Colloids and Surfaces A: Physicochemical and Engineering Aspects 460 , pp.219-224. (10.1016/j.colsurfa.2013.09.034)
- Perni, S. , Kong, M. G. and Prokopovich, P. 2012. Cold atmospheric pressure gas plasma enhances the wear performance of ultra-high molecular weight polyethylene. Acta Biomaterialia 8 (3), pp.1357-1365. (10.1016/j.actbio.2011.12.007)
- Perni, S. , Martini-Gilching, K. and Prokopovich, P. 2018. Controlling release kinetics of gentamicin from silica nano-carriers. Colloids and Surfaces A: Physicochemical and Engineering Aspects 541 , pp.212-221. (10.1016/j.colsurfa.2017.04.063)
- Perni, S. , Preedy, E. C. and Prokopovich, P. 2021. Amplify antimicrobial photo dynamic therapy efficacy with poly-beta-amino esters (PBAEs). Scientific Reports 11 (1) 7275. (10.1038/s41598-021-86773-3)
- Perni, S. et al. 2016. Influence of csgD and ompR on nanomechanics, adhesion forces and curli properties of E. coli. Langmuir 32 (31), pp.7965-7974. (10.1021/acs.langmuir.6b02342)
- Perni, S. , Preedy, E. C. and Prokopovich, P. 2014. Success and failure of colloidal approaches in adhesion of microorganisms to surfaces. Advances in Colloid and Interface Science 206 , pp.265-274. (10.1016/j.cis.2013.11.008)
- Perni, S. and Prokopovich, P. 2014. Continuous release of gentamicin from gold nanocarrier. RSC Advances 4 (94), pp.51904-51910. (10.1039/C4RA10023A)
- Perni, S. and Prokopovich, P. 2022. Feasibility and application of machine learning enabled fast screening of poly-beta-amino-esters for cartilage therapies. Scientific Reports 12 (1) 14215. (10.1038/s41598-022-18332-3)
- Perni, S. and Prokopovich, P. 2013. Micropatterning with conical features can control bacterial adhesion on silicone. Soft Matter 9 (6), pp.1844-1851. (10.1039/c2sm26828k)
- Perni, S. and Prokopovich, P. 2015. Multi-asperity elliptical JKR model for adhesion of a surface with non-axially symmetric asperities. Tribology International 88 , pp.107-114. (10.1016/j.triboint.2015.03.001)
- Perni, S. and Prokopovich, P. 2020. Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage. Journal of Materials Chemistry. B 8 (23), pp.5096-5108. (10.1039/C9TB02778E)
- Perni, S. and Prokopovich, P. 2017. Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage. Nanomedicine: Nanotechnology, Biology and Medicine 13 (2), pp.539-548. (10.1016/j.nano.2016.10.001)
- Perni, S. and Prokopovich, P. 2020. Rheometer enabled study of cartilage frequency-dependent properties. Scientific Reports 10 (1) 20696. (10.1038/s41598-020-77758-9)
- Perni, S. and Prokopovich, P. 2024. Risk equations for prosthetic joint infections (PJIs) in UK: a retrospective study using the Clinical Practice Research Datalink (CPRD) AURUM and GOLD databases. BMJ Open 14 (5) e082501. (10.1136/bmjopen-2023-082501)
- Perni, S. et al., 2010. Prevention of biofilm accumulation on a light-activated antimicrobial catheter material. Journal of Materials Chemistry 20 (39), pp.8668-8673. (10.1039/C0JM01891K)
- Perni, S. et al., 2009. Toluidine blue-containing polymers exhibit potent bactericidal activity when irradiated with red laser light. Journal of Materials Chemistry 19 (18), pp.2715-2723. (10.1039/B820561B)
- Perni, S. , Subburaman, S. and Prokopovich, P. 2025. Early cost-effectiveness analysis of intra-articular delivery of a PBAE-DEX conjugate for osteoarthritis in a UK population. Clinical Drug Investigation (10.1007/s40261-025-01446-7)
- Perni, S. et al. 2015. Antimicrobial activity of bone cements embedded with organic nanoparticles. International Journal of Nanomedicine 10 , pp.6317-6329. (10.2147/IJN.S86440)
- Perni, S. et al. 2018. Cobalt and Titanium nanoparticles influence on human osteoblast mitochondrial activity and biophysical properties of their cytoskeleton. Journal of Colloid and Interface Science 531 , pp.410-420. (10.1016/j.jcis.2018.07.028)
- Piccirillo, C. et al., 2009. Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface. Journal of Materials Chemistry 19 (34), pp.6167-6171. (10.1039/b905495b)
- Preedy, E. C. et al. 2014. Adhesive forces and surface properties of cold gas plasma treated UHMWPE. Colloids and Surfaces A: Physicochemical and Engineering Aspects 460 , pp.83-89. (10.1016/j.colsurfa.2014.03.052)
- Preedy, E. C. et al. 2014. Surface roughness mediated adhesion forces between borosilicate glass and gram-positive bacteria. Langmuir 30 (31), pp.9466-9476. (10.1021/la501711t)
- Preedy, E. C. , Perni, S. and Prokopovich, P. 2017. Cobalt and titanium nanoparticles influence on mesenchymal stem cell elasticity and turgidity. Colloids and Surfaces B: Biointerfaces 157 , pp.146-156. (10.1016/j.colsurfb.2017.05.019)
- Preedy, E. C. , Perni, S. and Prokopovich, P. 2015. Cobalt, titanium and PMMA bone cement debris influence on mouse osteoblast cell elasticity, spring constant and calcium production activity. RSC Advances 5 , pp.83885-83898. (10.1039/C5RA15390E)
- Preedy, E. C. , Perni, S. and Prokopovich, P. 2016. Nanomechanical and surface properties of rMSCs post exposure to CAP treated UHMWPE wear particles. Nanomedicine: Nanotechnology, Biology and Medicine 12 (3), pp.723-734. (10.1016/j.nano.2015.10.006)
- Prokopovich, P. 2014. Interactions between mammalian cells and nano- or micro-sized wear particles: Physico-chemical views against biological approaches. Advances in Colloid and Interface Science 213 , pp.36-47. (10.1016/j.cis.2014.09.001)
- Prokopovich, P. et al. 2015. Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid. Journal of Biomedical Materials Research: Part B - Applied Biomaterials 103 (2), pp.273-281. (10.1002/jbm.b.33196)
- Prokopovich, P. et al. 2013. A novel bone cement impregnated with silver-tiopronin nanoparticles: its antimicrobial, cytotoxic, and mechanical properties. International Journal of Nanomedicine 8 (1), pp.2227-2237. (10.2147/IJN.S42822)
- Prokopovich, P. and Perni, S. 2009. An investigation of microbial adhesion to natural and synthetic polysaccharide-based films and its relationship with the surface energy components. Journal of Materials Science: Materials in Medicine 20 (1), pp.195-202. (10.1007/s10856-008-3555-6)
- Prokopovich, P. and Perni, S. 2011. Comparison of JKR- and DMT-based multi-asperity adhesion model: Theory and experiment. Colloids and Surfaces A: Physicochemical and Engineering Aspects 383 (1-3), pp.95-101. (10.1016/j.colsurfa.2011.01.011)
- Prokopovich, P. and Perni, S. 2010. Prediction of the frictional behavior of mammalian tissues against biomaterials. Acta Biomaterialia 6 (10), pp.4052-4059. (10.1016/j.actbio.2010.05.007)
- Prokopovich, P. et al. 2011. Spatial variation of wear on Charité lumbar discs. Acta Biomaterialia 7 (11), pp.3914-3926. (10.1016/j.actbio.2011.06.036)
- Prokopovich, P. et al. 2010. Frictional Properties of Light-activated Silicone and Polyurethane against blood vessels. Journal of Materials Science: Materials in Medicine 21 (2), pp.815-821. (10.1007/s10856-009-3882-2)
- Prokopovich, P. and Perni, S. 2013. Contact interactions of aorta against PVC catheters. Tribology International 66 , pp.157-164. (10.1016/j.triboint.2013.03.009)
- Prokopovich, P. and Perni, S. 2010. Multiasperity contact adhesion model for universal asperity height and radius of curvature distributions. Langmuir 26 (22), pp.17028-17036. (10.1021/la102208y)
- Prokopovich, P. and Starov, V. 2011. Adhesion models: From single to multiple asperity contacts. Advances in Colloid and Interface Science 168 (1-2), pp.210-222. (10.1016/j.cis.2011.03.004)
- Prokopovich, P. , Starov, V. and Holdich, R. G. 2005. Concentration of inorganic salts in the permeate during nano- or ultrafiltration promoted by water-soluble polyelectrolytes in the feed solution. Industrial & Engineering Chemistry Research 44 (5), pp.1358-1369. (10.1021/ie049696l)
- Prokopovich, P. et al. 2006. Concentration of potassium cations in the permeate solution in the presence of N,N-dimethyl-N-2-propenyl-2-propen-1-aminium chloride homopolymer using dead-end nano-or ultrafiltration. Colloid Journal c/c of Kolloidnyi Zhurnal 68 (2), pp.211-216. (10.1134/S1061933X0602013X)
- Prokopovich, P. et al. 2010. Friction in ultra-thin conjunction of valve seals of pressurised metered dose inhalers. Wear 268 (5-6), pp.845-852. (10.1016/j.wear.2009.12.003)
- Ramadan, Y. et al., 2014. Obtaining new composite biomaterials by means of mineralization of methacrylate hydrogels using the reaction-diffusion method. Materials Science and Engineering C 42 , pp.696-704. (10.1016/j.msec.2014.06.017)
- Rivera, M. et al., 2019. Anti-inflammatory drug-eluting implant model system to prevent wear particles induced periprosthetic osteolysis. International Journal of Nanomedicine 14 , pp.1069-1084. (10.2147/IJN.S188193)
- Saeedi, T. , Alotaibi, H. F. and Prokopovich, P. 2020. Polymer colloids as drug delivery systems for the treatment of arthritis. Advances in Colloid and Interface Science 285 102273. (10.1016/j.cis.2020.102273)
- Saeedi, T. and Prokopovich, P. 2021. Poly beta amino ester coated emulsions of NSAIDs for cartilage treatment. Journal of Materials Chemistry B: Materials for biology and medicine 9 (29), pp.5837-5847. (10.1039/D1TB01024G)
- Saeedi, T. and Prokopovich, P. 2024. Screening of poly-beta amino ester coated emulsion of ketorolac for cartilage delivery †. Journal of Materials Chemistry B: Materials for biology and medicine 12 (24), pp.5930-5939. (10.1039/d4tb00313f)
- Sataev, M. S. et al., 2017. A low-temperature gold coating of the dielectric surfaces employing phosphine gas as a reducing agent. Colloids and Surfaces A: Physicochemical and Engineering Aspects 521 , pp.86-91. (10.1016/j.colsurfa.2016.11.029)
- Sataev, M. S. et al., 2015. A galvanic-chemical method for preparing diamond containing coatings. Colloids and Surfaces A: Physicochemical and Engineering Aspects 480 , pp.384-389. (10.1016/j.colsurfa.2014.09.014)
- Sataev, M. S. et al., 2014. Novel process for coating textile materials with silver to prepare antimicrobial fabrics. Colloids and Surfaces A: Physicochemical and Engineering Aspects 442 , pp.146-151. (10.1016/j.colsurfa.2013.02.018)
- Vicars, R. et al., 2012. The Effect of Anterior-Posterior Shear on the Wear of Charité TDR. Spine 37 (9), pp.E528-E534. (10.1097/BRS.0b013e31823cbd6e)
- Yang, L. et al. 2023. Nanocomposite orthopaedic bone cement combining long-acting dual antimicrobial drugs. Biomaterials Advances 153 213538. (10.1016/j.bioadv.2023.213538)
Book sections
- Prokopovich, P. 2012. A dimensionless analysis of the effect of material and surface properties on adhesion. applications to medical device design. In: Starov, V. and Griffiths, P. eds. Progress in Colloid and Polymer Sceinve. Vol. 139, Springer Verlag. , pp.59-65. (10.1007/978-3-642-28974-3_11)
Conferences
- Omar, F. et al. 2013. Demoulding forces in hot embossing: Model development and validation. Presented at: 8th International Conference on MicroManufacturing (ICOMM2013) Victoria, Canada 25-28 March 2013. Proceedings of the 8th International Conference on MicroManufacturing (ICOMM2013). , pp.642-649.
- Prokopovich, P. et al. 2010. Nano- and component level friction of rubber seals in dispensing devices. Presented at: ASME International Design Engineering Technical Conferences and Computers and Information in Engineering Conference San Diego, CA, USA 30 August-2 September 2009. ASME Power Transmission and Gearing Conference; 3rd International Conference on Micro- and Nanosystems; 11th International Conference on Advanced Vehicle and Tire Technologies. ASME Conference Proceedings Vol. 6. New York: ASME. , pp.339-344. (10.1115/DETC2009-86035)
Research
Current research projects:
-“Risk factors in prosthetic hip/knee joint replacement infections incidence and patient outcomes”
The aim is to explore the relationship between the risk of developing PJI and fixation types, intra-articular steroid injections, anticoagulants, smoking and other risk factors associated using the Clinical Practice Research Datalink (CPRD) datasets.
-“The Risk Factors Associated with Treatment Failure among Rheumatoid Arthritis Patients and the Use of Machine Learning Models to Predict the Treatment Response Based on Routinely Collected Data”
The aim is using CPRD data from UK clinical practice to evaluate the sociodemographic and clinical characteristics associated with the initiation of different rheumatoid arthritis treatments, compare the safety and effectiveness of different types of treatments and predict the treatment response using machine learning techniques.
- NHS
- Wellcome Trust
- Welsh Government
- Innovate UK
- EU funds
- Industries
Teaching
Undergraduate
Presentation assessment lead of PH1121 (Molecule to Patient)
Personal Tutor
Contribution to MPharm modules:
- PH1122 The role of the pharmacist in professional practice
- PH1123 Structure and function of cells and microbes
- PH1124 Human body systems
- PH1000 Professional development
- PH2107 Formulation Science I
- PH2113 Diseases and Drugs 1
- PH2000 Professional development
- PH2110 Clinical and Professional Pharmacy (OSCEs)
- PH3114 Design, formulation and quality assurance of medicinal products
- PH3202 Research methodology
- PH3000 Professional development
- PH4116 Pharmacy research or scholarship project
- EN3060 Biomaterials and Tissue Engineering
Postgraduate
- MSc course - Cancer and Experimental Therapeutics
- MSc and PhD student supervision
Contact Details
Research themes
Specialisms
- Big data
- Biofabrication
- Infectious diseases
- Medical devices
- Rheumatology and arthritis