Professor Anne Rosser
PhD, FRCP

Professor of Clinical Neuroscience, Division of Psychological Medicine and Clinical Neurosciences

Research overview

Advances in our understanding of mechanisms of cell death, plasticity and regeneration in the central nervous system offer new opportunities for remediation and repair in several of the most distressing neurodegenerative diseases of adulthood, in particular Parkinson's and Huntington's disease. In the Brain Repair Group, we are seeking to develop new strategies for therapy based on a multidisciplinary approach in several converging problems.

2018

Maxan, A. et al. 2018. Outcome of cell suspension allografts in a patient with Huntington's disease. Annals of Neurology 84(6), pp. 950-956. (10.1002/ana.25354)
Newland, H., Eigel, D., Rosser, A. E., Werner, C. and Newland, B. 2018. Oxygen producing microscale spheres affect cell survival in conditions of oxygen-glucose deprivation in a cell specific manner: implications for cell transplantation. Biomaterials Science 6(10), pp. 2571-2577. (10.1039/C8BM00490K)
Furby, H., Yhnell, E., Mazzaschi, F., Mole, J., Busse, M., Rosser, A. E. and Metzler-Baddeley, C. 2018. Using 3T MRI to explore myelin break-down in pre-symptomatic huntington’s disease. Journal of Neurology, Neurosurgery and Psychiatry 89(S1), pp. A37-A38., article number: E06. (10.1136/jnnp-2018-EHDN.100)
Busse, M. et al. 2018. J09 A new trial design for evaluating exercise outcomes in Huntington's Disease. Journal of Neurology, Neurosurgery and Psychiatry 89(Supp 1), pp. A100 - A101. (10.1136/jnnp-2018-EHDN.269)
Bennasar, M., Hicks, Y. A., Clinch, S. P., Jones, P., Holt, C., Rosser, A. and Busse-Morris, M. 2018. Automated assessment of movement impairment in Huntington's disease. IEEE Transactions on Neural Systems and Rehabilitation Engineering 26(10), pp. 2062-2069. (10.1109/TNSRE.2018.2868170)
Steventon, J. et al. 2018. Alterations in the metabolic and cardiorespiratory response to exercise in Huntington's Disease. Parkinsonism and Related Disorders 54, pp. 56-61. (10.1016/j.parkreldis.2018.04.014)
Telezhkin, V. et al. 2018. Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons. Pflügers Archiv European Journal of Physiology 470(9), pp. 1359-1376. (10.1007/s00424-018-2155-7)
Ciarochi, J. et al. 2018. High and low levels of an NTRK2-driven genetic profile affect motor- and cognition-associated frontal gray matter in prodromal Huntington's disease. Brain Sciences 8(7), article number: 116. (10.3390/brainsci8070116)
Massey, T., McAllister, B. and Jones, L. 2018. Methods for assessing DNA repair and repeat expansion in Huntington's Disease. In: Precious, S. V., Rosser, A. E. and Dunnett, S. B. eds. Huntington’s Disease., Vol. 1780. Methods in Molecular Biology Humana Press, pp. 483-495., (10.1007/978-1-4939-7825-0_22)
Holmans, P. and Stone, T. 2018. Using genomic data to find disease-modifying loci in Huntington's Disease (HD). In: Precious, S. V., Rosser, A. E. and Dunnett, S. eds. Huntington’s Disease., Vol. 1780. Methods in Molecular Biology Humana Press, pp. 443-461., (10.1007/978-1-4939-7825-0_20)
Roberton, V., Rosser, A. E., McGorrian, A. and Precious, S. V. 2018. Dissection and preparation of human primary fetal ganglionic eminence tissue for research and clinical applications. In: Precious, S., Rosser, A. and Dunnett, S. eds. Huntington’s Disease., Vol. 1780. Methods in Molecular Biology Humana Press, pp. 573-583., (10.1007/978-1-4939-7825-0_26)
Clinch, S. P., Busse, M., Lelos, M. J. and Rosser, A. E. 2018. Rethinking functional outcome measures: the development of an upper limb test to assess basal ganglia dysfunction. Frontiers in Neuroscience 12, article number: 366. (10.3389/fnins.2018.00366)
Harrison, D., Roberton, V., Vinh, N., Brooks, S., Dunnett, S. and Rosser, A. 2018. The effect of tissue preparation and donor age on striatal graft morphology in the mouse. Cell Transplantation 27(2), pp. 230-244. (10.1177/0963689717744788)
Yhnell, E. et al. 2018. Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study. Pilot and Feasibility Studies 4, article number: 45. (10.1186/s40814-018-0237-0)

2017

Hensman Moss, D. J. et al. 2017. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. Lancet Neurology 16(9), pp. 701-711. (10.1016/S1474-4422(17)30161-8)
van de Zande, N. A. et al. 2017. Clinical characterization of dystonia in adult patients with Huntington's disease. European Journal of Neurology 24(9), pp. 1140-1147. (10.1111/ene.13349)
Busse, M. et al. 2017. Physical activity self-management and coaching compared to social interaction in Huntington’s disease: Results from the ENGAGE-HD randomized, controlled, pilot feasibility trial. Physical Therapy 97(6), pp. 625-639. (10.1093/ptj/pzx031)
Precious, S. V., Zietlow, R., Dunnett, S. B., Kelly, C. and Rosser, A. E. 2017. Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?. Neurochemistry International 106, pp. 114-121. (10.1016/j.neuint.2017.01.016)
Li, M. and Rosser, A. E. 2017. Pluripotent stem cell-derived neurons for transplantation in Huntington's disease. In: Howard, C. J. ed. Functional Neural Transplantation. Progress in Brain Research Elsevier, pp. 263-281., (10.1016/bs.pbr.2017.02.009)
Dunnett, S. and Rosser, A. 2017. Reprogramming the diseased brain. Nature Biotechnology 35(5), pp. 426-428. (10.1038/nbt.3869)
Martín-Ibáñez, R. et al. 2017. Insights in spatio-temporal characterization of human fetal neural stem cells. Experimental Neurology 291, pp. 20-35. (10.1016/j.expneurol.2017.01.011)

2016

Drew, C. et al. 2016. Integrating technology into complex intervention trial processes: a case study. Trials 17(1), article number: 551. (10.1186/s13063-016-1674-9)
Jones, C. et al. 2016. The societal cost of Huntington’s disease: are we underestimating the burden?. European Journal of Neurology 23(10), pp. 1588-1590. (10.1111/ene.13107)
Quinn, L. et al. 2016. A randomized, controlled trial of a multi-modal exercise intervention in Huntington's disease. Parkinsonism and Related Disorders 31, pp. 46-52. (10.1016/j.parkreldis.2016.06.023)
Straccia, M., Carrere, J., Rosser, A. E. and Canals, J. M. 2016. Human t-DARPP is induced during striatal development. Neuroscience 333, pp. 320-330. (10.1016/j.neuroscience.2016.07.022)
Fritz, N. E., Hamana, K., Kelson, M., Rosser, A., Busse, M. and Quinn, L. 2016. Motor-cognitive dual-task deficits in individuals with early-mid stage Huntington's disease. Gait and Posture 49, pp. 283-289. (10.1016/j.gaitpost.2016.07.014)
Steventon, J. et al. 2016. Longitudinal in vivo MRI in a Huntington's disease mouse model: global atrophy in the absence of white matter microstructural damage. Scientific Reports 6, article number: 32423. (10.1038/srep32423)
Precious, S. V. et al. 2016. FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation. Experimental Neurology 282, pp. 9-18. (10.1016/j.expneurol.2016.05.002)
Jones, U. F., Busse, M., Enright, S. and Rosser, A. E. 2016. Respiratory decline is integral to disease progression in Huntington's disease [Letter]. European Respiratory Journal 48(2), pp. 585-588. (10.1183/13993003.02215-2015)
Steventon, J., Trueman, R. C., Rosser, A. E. and Jones, D. K. 2016. Robust MR-based approaches to quantifying white matter structure and structure/function alterations in Huntington's disease. Journal of Neuroscience Methods 265, pp. 2-12. (10.1016/j.jneumeth.2015.08.027)
Townhill, J. et al. 2016. Using Actiwatch to monitor circadian rhythm disturbance in Huntington' disease: A cautionary note. Journal of Neuroscience Methods 265, pp. 13-18. (10.1016/j.jneumeth.2016.01.009)
Lelos, M. J. et al. 2016. Direct comparison of rat- and human-derived ganglionic eminence tissue grafts on motor function. Cell Transplantation 25, pp. 665-675. (10.3727/096368915X690297)
Lelos, M., Morgan, R. J., Kelly, C., Torres, E. M., Rosser, A. E. and Dunnett, S. B. 2016. Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease. Experimental Neurology 278, pp. 54-61. (10.1016/j.expneurol.2016.02.003)
Quinn, L. et al. 2016. Development and delivery of a physical activity intervention for people with Huntington Disease. Journal of Neurologic Physical Therapy 40(2), pp. 71-80. (10.1097/NPT.0000000000000119)
Newland, B. et al. 2016. Synthesis of ROS scavenging microspheres from a dopamine containing poly(beta-amino ester) for applications for neurodegenerative disorders. Biomaterials Science 4(3), pp. 400-404. (10.1039/C5BM00542F)
Lewis, O. et al. 2016. Chronic, intermittent convection-enhanced delivery devices. Journal of Neuroscience Methods 259, pp. 47-56. (10.1016/j.jneumeth.2015.11.008)
Breydo, L., Newland, B., Zhang, H., Rosser, A. E., Werner, C., Uversky, V. N. and Wang, W. 2016. A hyperbranched dopamine-containing PEG-based polymer for the inhibition of a-synuclein fibrillation. Biochemical and Biophysical Research Communications 469(4), pp. 830-835. (10.1016/j.bbrc.2015.12.060)
Precious, S. V., Kelly, C. M., Allen, N. D. and Rosser, A. E. 2016. Can manipulation of differentiation conditions eliminate proliferative cells from a population of ES cell-derived forebrain cells?. Neurogenesis 3(1), article number: e1127311. (10.1080/23262133.2015.1127311)
Carvalho, J. O. et al. 2016. The impact of oculomotor functioning on neuropsychological performance in Huntington disease. Journal of Clinical and Experimental Neuropsychology 38(2), pp. 217-226. (10.1080/13803395.2015.1101054)
Bennasar, M., Hicks, Y. A., Clinch, S., Jones, P., Rosser, A. E., Busse, M. and Holt, C. A. 2016. Huntington's Disease assessment using tri axis accelerometers. Procedia Computer Science 96, pp. 1193-1201. (10.1016/j.procs.2016.08.163)

2015

Liu, D. et al. 2015. Motor onset and diagnosis in Huntington disease using the diagnostic confidence level. Journal of Neurology 262(12), pp. 2691-2698. (10.1007/s00415-015-7900-7)
Kim, J. et al. 2015. Multivariate clustering of progression profiles reveals different depression patterns in prodromal Huntington disease. Neuropsychology 29(6), pp. 949-960. (10.1037/neu0000199)
Newland, B. et al. 2015. Tackling cell transplantation anoikis: an injectable, shape memory cryogel microcarrier platform material for stem cell and neuronal cell growth. Small 11(38), pp. 5047-5053. (10.1002/smll.201500898)
Long, J. D., Paulsen, J. S., Rosser, A. and Hunt, S. 2015. Multivariate prediction of motor diagnosis in Huntington's disease: 12 years of PREDICT-HD. Movement Disorders 30(12), pp. 1664-1672. (10.1002/mds.26364)
Matsui, J. T. et al. 2015. Prefrontal cortex white matter tracts in prodromal Huntington disease. Human Brain Mapping 36(10), pp. 3717-3732. (10.1002/hbm.22835)
Straccia, M. et al. 2015. Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons. Molecular Therapy - Methods & Clinical Development 2, article number: 15030. (10.1038/mtm.2015.30)
Ferreira, J. J., Rosser, A. E., Craufurd, D., Squitieri, F., Mallard, N. and Landwehrmeyer, B. 2015. Ethyl-eicosapentaenoic acid treatment in Huntington's disease: A placebo-controlled clinical trial. Movement Disorders 30(10), pp. 1426-1429. (10.1002/mds.26308)
Wojtecki, L. et al. 2015. A prospective pilot trial for pallidal deep brain stimulation in Huntington's Disease. Frontiers in Neurology 6, article number: 177. (10.3389/fneur.2015.00177)
Steventon, J., Harrison, D. J., Trueman, R. C., Rosser, A. E., Jones, D. K. and Brooks, S. P. 2015. In Vivo MRI evidence that neuropathology is attenuated by cognitive enrichment in the Yac128 Huntington's Disease mouse model. Journal of Huntington's Disease 4(2), pp. 149-160. (10.3233/JHD-150147)
McCourt, A. C. et al. 2015. Characterization of gastric mucosa biopsies reveals alterations in Huntington's Disease. PLoS Currents 1 (10.1371/currents.hd.858b4cc7f235df068387e9c20c436a79)
Newland, B., Newland, H., Werner, C., Rosser, A. E. and Wang, W. 2015. Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders. Progress in Polymer Science 44, pp. 79-112. (10.1016/j.progpolymsci.2014.12.002)
Roberton, V. H., Rosser, A. E. and Kelly, C. M. 2015. Neonatal desensitization for the study of regenerative medicine. Regenerative Medicine 10(3), pp. 265-274. (10.2217/rme.14.76)
Arber, C. et al. 2015. Activin A directs striatal projection neuron differentiation of human pluripotent stem cells. Development 142(7), pp. 1375-1386. (10.1242/dev.117093)
Reilmann, R. et al. 2015. A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease. Movement Disorders 30(3), pp. 427-431. (10.1002/mds.26174)
Dawes, H. et al. 2015. Exercise testing and training in people with Huntington's diseas. Clinical Rehabilitation 29(2), pp. 196-206. (10.1177/0269215514540921)

2014

Reddington, A. E., Rosser, A. E. and Dunnett, S. B. 2014. Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient. Frontiers in Cellular Neuroscience 8, article number: 398. (10.3389/fncel.2014.00398)
Quinn, L. et al. 2014. Task-specific training in Huntington disease: a randomized controlled feasibility trial. Physical Therapy 94(11), pp. 1555-1568. (10.2522/ptj.20140123)
Rosser, A. E. and Dunnett, S. B. 2014. Cell therapy for Huntington's Disease. Advances in Clinical Neuroscience and Rehabilitation 14(5), pp. 18-21.
Collett, J. et al. 2014. Insights into gait disorders: walking variability using phase plot analysis, Huntington's Disease. Gait and Posture 40(4), pp. 694-700. (10.1016/j.gaitpost.2014.08.001)
Jones, U. F., Busse, M., Enright, S. and Rosser, A. E. 2014. Respiratory function decreases with progression of Huntington's Disease. Journal of Neurology, Neurosurgery & Psychiatry 85(Suppl), pp. A61-A62. (10.1136/jnnp-2014-309032.173)
Rosser, A. E. and Svendsen, C. N. 2014. Stem cells for cell replacement therapy: A therapeutic strategy for HD?. Movement Disorders 29(11), pp. 1446-1454. (10.1002/mds.26026)
Downing, N. R. et al. 2014. WHODAS 2.0 in prodromal Huntington disease: measures of functioning in neuropsychiatric disease. European Journal of Human Genetics 22(8), pp. 958-63. (10.1038/ejhg.2013.275)
Paulsen, J. S. et al. 2014. Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD study. Frontiers in Aging Neuroscience 6, article number: 78. (10.3389/fnagi.2014.00078)
Younes, L. et al. 2014. Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis. Human Brain Mapping 35(3), pp. 792-809. (10.1002/hbm.22214)
Varma, S. et al. 2014. Grainyheadlike 2 distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis. AJP: Lung Cellular and Molecular Physiology 306(5), pp. L405-L419. (10.1152/ajplung.00143.2013)
Long, J. D. et al. 2014. Tracking motor impairments in the progression of Huntington's disease. Movement Disorders 29(3), pp. 311-319. (10.1002/mds.25657)
Rinaldi, F. et al. 2014. Cross-regulation of Connexin43 and β-catenin influences differentiation of human neural progenitor cells. Cell Death and Disease 5(1), article number: e1017. (10.1038/cddis.2013.546)
Dascher-Nadel, C., Rosser, A. E. and Dunnett, S. B. 2014. Repair-HD: Human pluripotent stem cell differentiation, safety, and preparation for therapeutic transplantation in Huntington disease. HD Insights 8, pp. 9-10.
Dunnett, S. B. and Rosser, A. E. 2014. Challenges for taking primary and stem cells into clinical neurotransplantation trials for neurodegenerative disease. Neurobiology of Disease 61, pp. 79-89. (10.1016/j.nbd.2013.05.004)
Metzler-Baddeley, C., Cantera, J., Coulthard, E., Rosser, A. E., Jones, D. K. and Baddeley, R. J. 2014. Improved executive function and callosal white matter microstructure after rhythmn exercise in Huntington's disease. Journal of Huntington's Disease 3(3), pp. 273-283. (10.3233/JHD-140113)
Jones, K., Hamana, K., Quinn, L., Rosser, A. and Busse, M. 2014. Physiotherapy task orientated approach: A case report. Journal of neurology, neurosurgery and psychiatry 85(1), article number: A68. (10.1136/jnnp-2014-309032.192)
Busse, M. et al. 2014. Supporting physical activity engagement in people with Huntington's disease (ENGAGE-HD): study protocol for a randomized controlled feasibility trial. Trials 15(1), article number: 487. (10.1186/1745-6215-15-487)
Hrastelj, J., McLauchlan, D., Rosser, A. E. and Clenaghan, C. 2014. Hypercalcaemia mimicking Huntington's disease: lessons learned from delayed diagnosis. The Journal of the Royal College of Physicians of Edinburgh 44(4), pp. 286-288. (10.4997/JRCPE.2014.407)

2013

Roberton, V. H., Evans, A. E., Harrison, D. J., Precious, S. V., Dunnett, S. B., Kelly, C. and Rosser, A. E. 2013. Is the adult mouse striatum a hostile host for neural transplant survival?. NeuroReport 24(18), pp. 1010-1015. (10.1097/WNR.0000000000000066)
Busse, M. et al. 2013. A randomized feasibility study of a 12-week community-based exercise program for people with Huntington's Disease. Journal of Neurologic Physical Therapy 37(4), pp. 149-158., article number: 1557-0576/13/3704-0149. (10.1097/NPT.0000000000000016)
Hubers, A. A. et al. 2013. Suicidal ideation in a European Huntington's disease population. Journal of Affective Disorders 151(1), pp. 248-58. (10.1016/j.jad.2013.06.001)
Epping, E. A. et al. 2013. Characterization of depression in prodromal Huntington disease in the neurobiological predictors of HD (PREDICT-HD) study. Journal of Psychiatric Research 47(10), pp. 1423-31. (10.1016/j.jpsychires.2013.05.026)
Khalil, H., Quinn, L., Van Deursen, R. W. M., Dawes, H., Playle, R. A., Rosser, A. E. and Busse, M. 2013. What effect does a structured home-based exercise programme have on people with Huntington's disease? A randomized, controlled pilot study. Clinical Rehabilitation 27(7), pp. 646-658. (10.1177/0269215512473762)
McLauchlan, D. J. and Rosser, A. E. 2013. A systematic review of the behavioural symptoms in Huntington's disease: A cross-sectional and longitudinal approach [Conference Abstract]. Movement Disorders 28(S1), pp. S264-S264. (10.1002/mds.25605)
Barker, R. A. et al. 2013. The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry 84(6), pp. 657-665. (10.1136/jnnp-2012-302441)
Squitieri, F. et al. 2013. One-year safety and tolerability profile of pridopidine in patients with Huntington disease. Neurology 80(12), pp. 1086-1094. (10.1212/WNL.0b013e3182886965)
Brennan, S. C. et al. 2013. Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels. PLoS ONE 8(11), pp. e80294. (10.1371/journal.pone.0080294)
Dalton, A., Khalil, H., Busse, M., Rosser, A. E., Van Deursen, R. W. M. and ÓLaighin, G. 2013. Analysis of gait and balance through a single triaxial accelerometer in presymptomatic and symptomatic Huntington's disease. Gait & Posture 37(1), pp. 49-64. (10.1016/j.gaitpost.2012.05.028)
Harrison, D. J., Busse, M., Openshaw, R., Rosser, A. E., Dunnett, S. B. and Brooks, S. P. 2013. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Experimental Neurology 248, pp. 457-469. (10.1016/j.expneurol.2013.07.014)
Quinn, L., Busse, M. and Rosser, A. E. 2013. Critical features in the development of exercise-based interventions for people with Huntington's disease. European Neurological Review 8(1), pp. 10-13.
Lelos, M. J., Harrison, D. J., Rosser, A. E. and Dunnett, S. B. 2013. The lateral neostriatum is necessary for compensatory ingestive behaviour after intravascular dehydration in female rats. Appetite 71, pp. 287-294. (10.1016/j.appet.2013.09.003)
Kelly, C., Battersby, A. and Rosser, A. E. 2013. Stem cell transplantation for neurodegenerative disease: a distant dream?. Aging Health 9(2), pp. 139-148. (10.2217/ahe.13.16)
Grosset, D., Naveed, M., Aquino, C. C., Fox, S. H., Williams, S., Rosser, A. E. and Hughes, A. 2013. Journal Watch: Our panel of experts highlight the most important research articles across the spectrum of topics relevant to the field of neurodegenerative disease management. Neurodegenerative Disease Management 3(4), pp. 303-305. (10.2217/nmt.13.39)

2012

Brossman, B., Williams, J. K., Downing, N., Mills, J. A., Paulsen, J. S., Price, K. and Rosser, A. 2012. Development of the Huntington disease work function scale. Journal of Occupational and Environmental Medicine 54(10), pp. 1300-1308. (10.1097/JOM.0b013e31825f30ab)
Evans, A. E., Kelly, C., Precious, S. V. and Rosser, A. E. 2012. Molecular regulation of striatal development: a review. Anatomy Research International 2012, article number: 106529. (10.1155/2012/106529)
Kelly, C., Roberton, V. H., Dunnett, S. B. and Rosser, A. E. 2012. Reply to "Neonatal desensitization does not universally prevent xenograft rejection". Nature Methods 9(9), pp. 858. (10.1038/nmeth.2144)
Dunnett, S. B., Fuller, A., Rosser, A. E. and Brooks, S. P. 2012. A novel extended sequence learning task (ESLeT) for rodents: validation and the effects of amphetamine, scopolamine and striatal lesions. Brain Research Bulletin 88(2-3), pp. 237-250. (10.1016/j.brainresbull.2010.10.005)
Dunnett, S. B., Heuer, A., Lelos, M. J., Brooks, S. P. and Rosser, A. E. 2012. Bilateral striatal lesions disrupt performance in an operant delayed reinforcement task in rats. Brain Research Bulletin 88(2-3), pp. 251-260. (10.1016/j.brainresbull.2011.04.002)
Harrington, D. L., Smith, M. M., Zhang, Y., Carlozzi, N. E., Paulsen, J. S., Price, K. and Rosser, A. E. 2012. Cognitive domains that predict time to diagnosis in prodromal Huntington disease. Journal of Neurology, Neurosurgery & Psychiatry 83(6), pp. 612-619. (10.1136/jnnp-2011-301732)
Long, J. D., Matson, W. R., Juhl, A. R., Leavitt, B. R., Paulsen, J. S., Price, K. and Rosser, A. E. 2012. 8OHdG as a marker for Huntington disease progression. Neurobiology of Disease 46(3), pp. 625-634. (10.1016/j.nbd.2012.02.012)
Zietlow, R., Precious, S. V., Kelly, C., Dunnett, S. B. and Rosser, A. E. 2012. Long-term expansion of human foetal neural progenitors leads to reduced graft viability in the neonatal rat brain. Experimental Neurology 235(2), pp. 563-573. (10.1016/j.expneurol.2012.03.010)
Aylward, E. H. et al. 2012. Striatal volume contributes to the prediction of onset of Huntington disease in incident cases. Biological psychiatry 71(9), pp. 822-828. (10.1016/j.biopsych.2011.07.030)
Precious, S. V. and Rosser, A. E. 2012. Producing striatal phenotypes for transplantation in Huntington's disease. Experimental Biology and Medicine 237(4), pp. 343-351. (10.1258/ebm.2011.011359)
Busse, M. et al. 2012. A randomised feasibility study of a 12-week exercise programme in Huntington’s disease (HD). Journal of Neurology, Neurosurgery & Psychiatry 83, pp. A58-A59. (10.1136/jnnp-2012-303524.182)
Hamana, K. et al. 2012. Perspectives of participating in a 12-week exercise programme for people with early -mid stage Huntington's disease. Journal of Neurology, Neurosurgery & Psychiatry 83(S. 1), pp. A59. (10.1136/jnnp-2012-303524.183)
Quarrell, O. W. et al. 2012. Discrepancies in reporting the CAG repeat lengths for Huntington's disease. European Journal of Human Genetics 20(1), pp. 20-26. (10.1038/ejhg.2011.136)
Khalil, H., Quinn, L., Van Deursen, R. W. M., Martin, R., Rosser, A. E. and Busse, M. 2012. Adherence to use of a home-based exercise DVD in people with Huntington Disease: participants' perspectives. Physical Therapy 92(1), pp. 69-82. (10.2522/ptj.20100438)
Rosser, A. E. 2012. Why cannot a rodent be more like a man? A clinical perspective. In: Lane, E. L. and Dunnett, S. B. eds. Animal models of movement disorders., Vol. 1. Neuromethods Vol. 61. New York: Humana Press, pp. 3-9., (10.1007/978-1-61779-298-4_1)
Busse, M. et al. 2012. Q12 A randomised feasibility study of a 12-week exercise programme in Huntington's disease (HD) [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 83(S1), pp. A58-A59. (10.1136/jnnp-2012-303524.182)
Hamana, K. et al. 2012. Q13 Perspectives of participating in a 12-week exercise programme for people with early -mid stage Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 83(S1), pp. A59. (10.1136/jnnp-2012-303524.183)
Khalil, H., Quinn, L., Van Deursen, R. W. M., Dawes, H., Playle, R., Rosser, A. E. and Busse, M. 2012. Q15 A pilot study of an exercise intervention to improve motor function in people with Huntington's disease (HD) [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S1), pp. A59. (10.1136/jnnp-2012-303524.185)
Jones, K. et al. 2012. Q14 Sub maximal exercise testing in people with early stage Huntington's disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S1), pp. A59. (10.1136/jnnp-2012-303524.184)
Rosser, A. E. and Bachoud-Lévi, A. 2012. Clinical trials of neural transplantation in Huntington's disease. In: Progress in Brain Research., Vol. 200. Elsevier, pp. 345-371., (10.1016/B978-0-444-59575-1.00016-8)
Busse, M., Khalil, H., Quinn, L., Brooks, S. P. and Rosser, A. E. 2012. Practice, progress and future directions for physical therapies in Huntington's Disease. Journal of Huntington's Disease 1(2), pp. 175-185. (10.3233/JHD-120025)
Jones, K. et al. 2012. Sub maximal exercise testing in people with early stage Huntington’s Disease [Abstract]. Journal of Neurology, Neurosurgery and Psychiatry 83(S. 1), article number: A59. (10.1136/jnnp-2012-303524.184)
Smith, M. M., Mills, J. A., Epping, E. A., Westervelt, H. J., Paulsen, J. S., Price, K. and Rosser, A. 2012. Depressive symptom severity is related to poorer cognitive performance in prodromal Huntington disease. Neuropsychology 26(5), pp. 664-669. (10.1037/a0029218)
Hughes, A., Rosser, A. E. and Jones, L. 2012. E06 Family history curation in Huntington's disease: a survey of the data so far. Journal of Neurology, Neurosurgery & Psychiatry 83(Suppl), pp. A21-A21. (10.1136/jnnp-2012-303524.65)

2011

Orth, M. et al. 2011. Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY [Letter]. Journal of Neurology, Neurosurgery & Psychiatry 82(12), pp. 1409-1412. (10.1136/jnnp.2010.209668)
de Yebenes, J. G. et al. 2011. Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): A phase 3, randomised, double-blind, placebo-controlled trial. The Lancet Neurology 10(12), pp. 1049-1057. (10.1016/S1474-4422(11)70233-2)
Dunnett, S. B. and Rosser, A. E. 2011. Clinical translation of cell transplantation in the brain. Current Opinion in Organ Transplantation 16(6), pp. 632-639. (10.1097/MOT.0b013e32834c2356)
Saft, C. et al. 2011. NMDA receptor gene variations as modifiers in Huntington disease: a replication study. PLoS Currents 3, article number: RRN1247. (10.1371/currents.RRN1247)
Jones, U. F., Busse, M., Enright, S. and Rosser, A. E. 2011. A pilot study of influences on physical activity level and exercise capacity in people with Huntington's disease [Abstract]. Physiotherapy 97(s1), pp. eS570., article number: RR-PL-1276. (10.1016/j.physio.2011.04.002)
Rosser, A. E., Kelly, C. and Dunnett, S. B. 2011. Cell transplantation for Huntington's disease: practical and clinical considerations. Future Neurology 6(1), pp. 45-62. (10.2217/fnl.10.78)
Kelly, C. et al. 2011. Medical terminations of pregnancy: A viable source of tissue for cell replacement therapy for neurodegenerative disorders. Cell Transplantation 20(4), pp. 503-513. (10.3727/096368910X546580)
Dunnett, S. B. and Rosser, A. E. 2011. Cell-based treatments for Huntington's disease. International Review of Neurobiology 98, pp. 483-508. (10.1016/B978-0-12-381328-2.00017-1)
Cordero-Llana, O. et al. 2011. Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells. Cell Death and Differentiation 18(5), pp. 907-913. (10.1038/cdd.2010.169)
Hollins, A. J., Joy, S., Kelly, C. M., Battersby, A. A., Allen, N. D. and Rosser, A. E. 2011. Transplantation of differentiated human embryonic stem cells into a Huntington's Disease model: The challenges of generating neural cells suitable for replacement therapy in neurodegenerative disease. Cell Transplantation 20(4), pp. 563-564.

2010

Soneson, C. et al. 2010. Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis. Neurobiology of Disease 40(3), pp. 531-543. (10.1016/j.nbd.2010.07.013)
Nopoulos, P. C. et al. 2010. Cerebral cortex structure in prodromal Huntington disease. Neurobiology of Disease 40(3), pp. 544-554. (10.1016/j.nbd.2010.07.014)
Paulsen, J. S. et al. 2010. Challenges assessing clinical endpoints in early Huntington disease. Movement Disorders 25(15), pp. 2595-2603. (10.1002/mds.23337)
Dobrossy, M., Busse, M., Piroth, T., Rosser, A. E., Dunnett, S. B. and Nikkhah, G. 2010. Review: Neurorehabilitation With Neural Transplantation. Neurorehabilitation and Neural Repair 24(8), pp. 692-701. (10.1177/1545968310363586)
Orth, M. et al. 2010. Observing Huntington's Disease: the European Huntington's Disease Network's REGISTRY. PLoS Currents 2, pp. RRN1184. (10.1371/currents.RRN1184)
Duff, K. et al. 2010. Mild cognitive impairment in prediagnosed Huntington disease. Neurology 75(6), pp. 500-507. (10.1212/WNL.0b013e3181eccfa2)
Langbehn, D. R., Hayden, M. R., Paulsen, J. S., PREDICT-HD Investigators of the Huntington Study Group, . and Rosser, A. E. 2010. CAG-repeat length and the age of onset in Huntington disease (HD): A review and validation study of statistical approaches. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B(2), pp. 397-408. (10.1002/ajmg.b.30992)
Quinn, L., Busse, M., Khalil, H., Richardson, S., Rosser, A. E. and Morris, H. R. 2010. Client and therapist views on exercise programmes for early-mid stage Parkinson's disease and Huntington's disease. Disability & Rehabilitation 32(11), pp. 917-928. (10.3109/09638280903362712)
Jones, U. F., Enright, S., Busse, M. and Rosser, A. E. 2010. A pilot study on respiratory function in people with Huntington’s disease [J11 Abstract]. Journal of neurology, neurosurgery and psychiatry 81(Supp 1), pp. A42-A43.
Döbrössy, M., Busse, M., Piroth, T., Rosser, A. E., Dunnett, S. B. and Nikkhah, G. 2010. Neurorehabilitation and neural transplantation. Neurorehabilitation and Neural Repair 24(8), pp. 692-701. (10.1177/1545968310377604)
Madete, J. K., Klein, A., Fuller, A., Trueman, R., Rosser, A. E., Dunnett, S. B. and Holt, C. A. 2010. Challenges facing quantification of rat locomotion along beams of varying widths. Proceedings of the Institution of Mechanical Engineers Part H-Journal of Engineering in Medicine 224(11), pp. 1257-1265. (10.1243/09544119JEIM779)
Madete, J., Fuller, A., Klein, A., Trueman, R., Dunnett, S. B., Rosser, A. E. and Holt, C. A. 2010. Quantification of rat locomotion along beams of varying widths. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
Madete, J. K., Fuller, A., Klein, A., Trueman, R., Dunnett, S. B., Rosser, A. E. and Holt, C. A. 2010. Postural adjustments of an animal model of Parkinson's disease during over-ground locomotion. Presented at: 9th International Conference on Computer Methods in Biomechanics and Biomedical Engineering, Valencia, Spain.
Busse, M., Al-Madfai, H., Kenkre, J., Landwehrmeyer, G. B., Bentivoglio, A. and Rosser, A. E. 2010. Utilisation of Healthcare and Associated Services in Huntington's disease: a data mining study. PLoS Currents 3, article number: RRN1206. (10.1371/currents.RRN1206)
Hughes, A., Price, K., Mason, D., Evans, B., Pettit, R., Evans, W. and Rosser, A. E. 2010. F21 Is bone density altered in early stage huntington's disease patients? - a pilot study [Conference Abstract]. Journal of Neurology, Neurosurgery & Psychiatry 81(Suppl), pp. A29-A29. (10.1136/jnnp.2010.222620.21)

2009

Aziz, N. A. et al. 2009. Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease. Neurology 73(16), pp. 1280-1285. (10.1212/WNL.0b013e3181bd1121)
Biglan, K. M. et al. 2009. Motor abnormalities in premanifest persons with Huntington's disease: The PREDICT-HD study. Movement Disorders 24(12), pp. 1763-1772. (10.1002/mds.22601)
Kelly, C., Handley, O. J. and Rosser, A. 2009. Human trials for neurodegenerative disease. In: Scolding, N. J. and Gordon, D. eds. Neural Cell Transplantation: Methods and Protocols. Methods in Molecular Biology Vol. 549. New York: Humana Press, pp. 33-47., (10.1007/978-1-60327-931-4_3)
Kelly, C. M. et al. 2009. Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression. Nature Methods 6(4), pp. 271-273. (10.1038/nmeth.1308)
Jones, U. F., Jones, L., Enright, S., Busse, M. and Rosser, A. E. 2009. Measuring inspiratory muscle strength using sniff nasal inspiratory pressure in Huntington’s Disease. [Abstract C08]. Clinical Genetics 76(Supp 1), pp. 56-56. (10.1111/j.1399-0004.2009.01221.x)
Busse, M., Wiles, C. M. and Rosser, A. E. 2009. Mobility and falls in people with Huntington's disease. Journal of Neurology Neurosurgery and Psychiatry 80(1), pp. 88-90. (10.1136/jnnp.2008.147793)
Davies, D., Rosser, A. E. and Sarangi, S. 2009. Carers' Participation in Decision Making in a Huntingdon's disease management clinic. Journal of Medical Genetics 46, pp. S107-S107.
Bisson, J. I., Hampton, V. L., Rosser, A. E. and Holm, S. 2009. Developing a care pathway for advance decisions and powers of attorney: qualitative study. British Journal of Psychiatry 194(1), pp. 55-61. (10.1192/bjp.bp.107.048900)
Kelly, C., Dunnett, S. B. and Rosser, A. E. 2009. Medium spiny neurons for transplantation in Huntington's disease. Biochemical Society Transactions 37(1), pp. 323-328. (10.1042/BST0370323)
Paynter, S. J., Andrews, K., Vinh, N., Kelly, C., Rosser, A. E., Amso, N. N. J. and Dunnett, S. B. 2009. Membrane permeability coefficients of murine primary neural brain cells in the presence of cryoprotectant. Cryobiology 58(3), pp. 308-314. (10.1016/j.cryobiol.2009.02.008)
Paynter, S. J., Andrews, K. J., Vinh, N., Kelly, C., Rosser, A. E., Amso, N. N. and Dunnett, S. B. 2009. Membrane permeability coefficients of murine primary neural brain cells in the presence of cryoprotectant. Cryoletters 29(1), pp. 84.
Madete, J., Holt, C. A., Lawrence, A., Ben-Hammada, A., Dunnett, S. B. and Rosser, A. E. 2009. Quantifying voluntary imitation of facial expressions. Presented at: Proceedings of the ISB Congress (ISB2009), Cape Town, South Africa.

2008

Busse, M., Hughes, G., Wiles, C. M. and Rosser, A. E. 2008. Use of hand-held dynamometry in the evaluation of lower limb muscle strength in people with Huntington's disease. Journal of Neurology 255(10), pp. 1534-1540. (10.1007/s00415-008-0964-x)
Lane, E. L., Handley, O. J., Rosser, A. E. and Dunnett, S. B. 2008. Potential cellular and regenerative approaches for the treatment of Parkinson's disease. Neuropsychiatric Disease and Treatment 4(5), pp. 835-845. (10.2147/NDT.S2013)
Zietlow, R., Lane, E. L., Dunnett, S. B. and Rosser, A. E. 2008. Human stem cells for CNS repair. Cell and Tissue Research 331(1), pp. 301-322. (10.1007/s00441-007-0488-1)
Wardle, M., Majounie, E., Williams, N. M., Rosser, A. E., Morris, H. R. and Robertson, N. 2008. Dentatorubral pallidoluysian atrophy in South Wales. Journal of Neurology, Neurosurgery and Psychiatry 79(7), pp. 804-807. (10.1136/jnnp.2007.128074)
Busse, M., Khalil, H., Quinn, L. and Rosser, A. E. 2008. Physical therapy intervention for people with Huntington disease. Physical Therapy 88(7), pp. 820-31. (10.2522/ptj.20070346)
Madete, J. K., Holt, C. A., Ben-Hammada, A., Lawrence, A. D., Dunnett, S. B. and Rosser, A. E. 2008. Quantifying voluntary imitation of facial expressions. Presented at: Proceedings of the International Society of Biomechanics, 3D Motion Analysis Meeting (3DMA2008), Santpoort-Amsterdam, Netherlands.
Madete, J. K., Holt, C. A., White, A., Sprinz, P., Bruce., D. S. and Rosser, A. E. 2008. 3D motion capture of Parkinson's and Huntington's disease rat models. Presented at: Proceedings of the International Society of Biomechanics, 3D Motion Analysis Meeting (3DMA2008), Santpoort-Amsterdam, Netherlands.
Meaney, A., Busse, M., Dawes, H. and Rosser, A. E. 2008. Response to a structured exercise programme for Huntington's Disease [Abstract]. Journal of Sport Science 26(S2), pp. 125-126. (10.1080/02640410802306202)

2007

Varani, K. et al. 2007. Biological abnormalities of peripheral A2A receptors in a large representation of polyglutamine disorders and Huntington's disease stages. Neurobiology of Disease 27(1), pp. 36-43. (10.1016/j.nbd.2007.03.011)
Dunnett, S. B. and Rosser, A. E. 2007. Cell transplantation for Huntington's disease: Should we continue?. Brain Research Bulletin 72(2-3), pp. 132-147. (10.1016/j.brainresbull.2006.10.019)
Kelly, C., Precious, S. V., Penketh, R., Amso, N. N., Dunnett, S. B. and Rosser, A. E. 2007. Striatal graft projections are influencd by donor cell type and not the immunogenic background. Brain 130, pp. 1317-1329. (10.1093/brain/awm053)
Busse, M. and Rosser, A. E. 2007. Can directed activity improve mobility in Huntington's disease?. Brain Research Bulletin 72(2-3), pp. 172-174. (10.1016/j.brainresbull.2006.10.021)
Kelly, C., Precious, S. V., Penketh, R., Amso, N. N., Dunnett, S. B. and Rosser, A. E. 2007. Striatal graft projections are influenced by donor cell type and not the immunogenic background. Brain 130(5), pp. 1317-1329. (10.1093/brain/awm053)
Joannides, A. J. et al. 2007. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain 130(5), pp. 1263-1275. (10.1093/brain/awm070)
Dunnett, S. B. and Rosser, A. E. 2007. Neural transplantation in Parkinson's Disease. In: Halberstadt, C. and Emerich, D. eds. Cellular Transplantation: From Laboratory to Clinic. Amsterdam ; Boston: Elsevier Academic Press, pp. 439-454., (10.1016/B978-012369415-7/50026-0)
Rosser, A. E. and Dunnett, S. B. 2007. Neural transplantation in Huntington's disease. In: Halberstadt, C. and Emerich, D. eds. Cellular Transplantation: From Laboratory to Clinic. Amsterdam; Boston: Elsevier Academic Press, pp. 417-437., (10.1016/B978-012369415-7/50025-9)
Rosser, A. E., Zietlow, R. and Dunnett, S. B. 2007. Stem cell transplantation for neurodegenerative diseases. Current Opinion in Neurology 20(6), pp. 688-692. (10.1097/WCO.0b013e3282f132fc)
Dunnett, S. B. and Rosser, A. E. 2007. Stem cell transplantation for Huntington's disease. Experimental Neurology 203(2), pp. 279-292. (10.1016/j.expneurol.2006.11.007)

2006

Farrington, M., Wreghitt, T. G., Lever, A. M. L., Dunnett, S. B., Rosser, A. E. and Barker, R. A. 2006. Neural transplantation in Huntington's disease: the NEST-UK Donor Tissue Microbiological Screening Program and review of the literature. Cell Transplantation 15(4), pp. 279-294. (10.3727/000000006783981927)
Rosser, A. E. and Dunnett, S. B. 2006. Cell transplantation for Huntington's disease. The Lancet Neurology 5(4), pp. 284-285. (10.1016/S1474-4422(06)70385-4)
Handley, O. J., Naji, J. J., Dunnett, S. B. and Rosser, A. E. 2006. Pharmaceutical, cellular and genetic therapies for Huntington's disease. Clinical Science 110(1), pp. 73-88. (10.1042/CS20050148)
Rosser, A. E. and Allen, N. D. 2006. Help for huntington's: stem cells for neurodegenerative disease. The Biochemist 28, pp. 19-24.
Hughes, A., Evans, B. A. J., Rosser, A. E. and Mason, D. J. 2006. Do polyglutamine tracts in huntingtin influence glutamate signalling in bone? [Conference Abstract]. Calcified Tissue International 78(S1), pp. S58-S58.

2005

Kelly, C., Tyers, P., Borg, M. t., Svendsen, C. N., Dunnett, S. B. and Rosser, A. E. 2005. EGF and FGF-2 responsiveness of rat and mouse neural precursors derived from the embryonic CNS. Brain Research Bulletin 68(1-2), pp. 83-94. (10.1016/j.brainresbull.2005.08.020)
Rosser, A. E. 2005. Brain repair: Moving along. Brain Research Bulletin 68(1-2), pp. 1-3. (10.1016/j.brainresbull.2005.09.006)
Zietlow, R., Pekarik, V., Armstrong, R. J. E., Tyers, P., Dunnett, S. B. and Rosser, A. E. 2005. The survival of neural precursor cell grafts is influenced by in vitro expansion. Journal of Anatomy 207(3), pp. 227-240. (10.1111/j.1469-7580.2005.00449.x)

2004

Dunnett, S. B. and Rosser, A. E. 2004. Cell therapy in Huntington's disease. NeuroRX 1(4), pp. 394-405. (10.1602/neurorx.1.4.394)

2003

Jain, M., Armstrong, R. J. E., Tyers, P., Barker, R. A. and Rosser, A. E. 2003. GABAergic immunoreactivity is predominant in neurons derived from expanded human neural precursor cells in vitro. Experimental Neurology 182(1), pp. 113-123. (10.1016/S0014-4886(03)00055-4)
Jain, M., Armstrong, R., Elneil, S., Rosser, A. E. and Barker, R. 2003. Migration and differentiation of transplanted human neural precursor cells.. NeuroReport 14(9), pp. 1257-1262.
Armstrong, R. J. E., Tyers, P., Jain, M., Richards, A., Dunnett, S. B., Rosser, A. E. and Barker, R. A. 2003. Transplantation of expanded neural precursor cells from the developing pig ventral mesencephalon in a rat model of Parkinson's disease. Experimental Brain Research 151(2), pp. 204-217. (10.1007/s00221-003-1491-8)
Ho, A. K. et al. 2003. A case of unilateral neglect in Huntington's Disease. Neurocase 9(3), pp. 261-273. (10.1076/neur.9.3.261.15559)
Pavese, N. et al. 2003. Progressive striatal and cortical dopamine receptor dysfunction in Huntington's disease: a PET study. Brain 126(5), pp. 1127-1135. (10.1093/brain/awg119)
Rosser, A. E. and Dunnett, S. B. 2003. Neural transplantation in patients with Huntington's disease. CNS Drugs 17(12), pp. 853-867. (10.2165/00023210-200317120-00001)
Rosser, A. E. et al. 2003. Staging and preparation of human fetal striatal tissue for neural transplantation in huntington's disease. Cell Transplantation 12(7), pp. 679-686. (10.3727/000000003108747299)
Hurelbrink, C. B., Tyers, P., Armstrong, R. J., Dunnett, S. B., Barker, R. A. and Rosser, A. E. 2003. Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival:implications for clinical trials in huntington's disease. Cell Transplantation 12(7), pp. 687-695. (10.3727/000000003108747307)
Kelly, C. M., Zietlow, R., Dunnett, S. B. and Rosser, A. E. 2003. The Effects of Various Concentrations of FGF-2 on the Proliferation and Neuronal Yield of Murine Embryonic Neural Precursor Cells In Vitro. Cell Transplantation 12(3), pp. 215-223. (10.3727/000000003108746777)

2002

Rosser, A. E. et al. 2002. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475. Journal of neurology neurosurgery and psychiatry 73(6), pp. 678-685. (10.1136/jnnp.73.6.678)
Rosser, A. E. et al. 2002. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report (ISRCTN no 36485475). Journal of neurology neurosurgery and psychiatry, pp. 678-685. (10.1136/JNNP.73.6.678)
Kelly, C. M., Zietlow, R. and Rosser, A. 2002. Stem cell proliferation and differentiation.. Experimental Neurology 175(2), pp. 432-432.
Jain, M., Hurelbrink, C. B., Armstrong, R. J. E., Rosser, A. and Barker, R. A. 2002. Widespread migration of human expanded neural precursors in the 6-OHDA model of Parkinson's disease.. Experimental Neurology 175(2), pp. 431-432.
Hurelbrink, C. B., Armstrong, R. J. E., Dunnett, S. B., Rosser, A. and Barker, R. A. 2002. Extensive migration of neural cells from primary striatal xenografts. Experimental Neurology 175(2), pp. 426-427.
Armstrong, R. J. E. et al. 2002. The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease. Experimental neurology 175(1), pp. 98-111. (10.1006/exnr.2002.7889)
Hurelbrink, C. B., Armstrong, R. J. E., Dunnett, S. B., Rosser, A. and Barker, R. A. 2002. Neural cells from primary human striatal xenografts migrate extensively in the adult rat CNS. European Journal of Neuroscience 15(7), pp. 1255-1266. (10.1046/j.1460-9568.2002.01959.x)
Berrios, G. E., Wagle, A. C., Markova, I. S., Wagle, S. A., Rosser, A. and Hodges, J. R. 2002. Psychiatric symptoms in neurologically asymptomatic Huntington's disease gene carriers: a comparison with gene negative at risk subjects. Acta Psychiatrica Scandinavica 105(3), pp. 224-230. (10.1034/j.1600-0447.2002.0o456.x)
Rosser, A. and Dunnett, S. 2002. New drugs for Huntington's disease. NeuroReport 13(2), pp. A21-A22.
Ho, A. K., Sahakian, B. J., Robbins, T. W., Barker, R. A., Rosser, A. E. and Hodges, J. R. 2002. Verbal fluency in Huntington's disease: a longitudinal analysis of phonemic and semantic clustering and switching. Neuropsychologia 40(8), pp. 1277-1284. (10.1016/S0028-3932(01)00217-2)

2001

Armstrong, R. J. et al. 2001. Porcine neural xenografts in the immunocompetent rat: immune response following grafting of expanded neural precursor cells. Neuroscience 106(1), pp. 201-216. (10.1016/S0306-4522(01)00273-1)
Hurelbrink, C. B., Armstrong, R. J., Luheshi, L. M., Dunnett, S., Rosser, A. E. and Barker, R. A. 2001. Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activation. Exp Neurol 171(1), pp. 46-58., article number: 11520120.
Berrios, G. E. et al. 2001. Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington's disease gene carriers. Psychiatry Research 102(3), pp. 217-215.
Jain, M., Armstrong, R. J., Barker, R. A. and Rosser, A. E. 2001. Cellular and molecular aspects of striatal development. Brain Research Bulletin 55(4), pp. 553-540.
Barker, R. A. and Rosser, A. E. 2001. Neural transplantation therapies for Parkinson's and Huntington's diseases. Drug Discovery Today 6(11), pp. 575-582. (10.1073/pnas.0904239106)
Pavese, N. et al. 2001. Huntington's disease progression measured with serial [11C]-raclopride PET and the UHDRS. Neurology 56(8), pp. A385-A385.
Armstrong, R. J., Rosser, A. E., Dunnett, S. B. and Barker, R. A. 2001. Neural stem cell technology as a novel treatment for Parkinson's disease. Methods in molecular medicine 62, pp. 289-307. (10.1385/1-59259-142-6:289)
Lawrence, A. D., Rosser, A. E. and Sahakian, B. J. 2001. Cognition. In: Fawcett, J. W., Rosser, A. E. and Dunnett, S. B. eds. Brain Damage, Brain Repair. Oxford: Oxford University Press, pp. 243-254., (10.1093/acprof:oso/9780198523376.003.0018)

2000

Rosser, A. E. 2000. Stem cell research--will further work be permitted?. NeuroReport 11(18), pp. A15.
Hurelbrink, C. B., Armstrong, R. J., Barker, R. A., Dunnett, S. B. and Rosser, A. E. 2000. Hibernated human fetal striatal tissue: successful transplantation in a rat model of Huntington's disease. Cell Transplantation 9(6), pp. 743-749.
Rosser, A. E., Tyers, P. and Dunnett, S. B. 2000. The morphological development of neurons derived from EGF- and FGF-2-driven human CNS precursors depends on their site of integration in the neonatal rat brain. European Journal of Neuroscience 12(7), pp. 2405-2413. (10.1046/j.1460-9568.2000.00135.x)
Armstrong, R. J., Watts, C., Svendsen, C. N., Dunnett, S. B. and Rosser, A. E. 2000. Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease. Cell Transplantation 9(1), pp. 55-64.
Rosser, A. E., Ostendeld, T. and Svendsen, C. N. 2000. Invited commentary: treatment of diseases of the central nervous system using encapsulated cells, by A. F. Hottinger and P. Aebischer (Advances and Technical Standards in Neurosurgery vol. 25).. Advances and technical standards in neurosurgery 26, pp. 125-128.
Watkins, L. H. A., Rogers, R. D., Lawrence, A. D., Sahakian, B. J., Rosser, A. E. and Robbins, T. W. 2000. Impaired planning but intact decision making in early Huntington's disease: implications for specific fronto-striatal pathology. Neuropsychologia 38(8), pp. 1112-1125. (10.1016/S0028-3932(00)00028-2)

1999

Andrews, T. C. et al. 1999. Huntington's disease progression. PET and clinical observations. Brain 122(12), pp. 2353-2363. (10.1093/brain/122.12.2353)
Rosser, A. E. 1999. Cell transplantation for neurological disorders. Journal of Neurology, Neurosurgery & Psychiatry 67(6), pp. 833C. (10.1136/jnnp.67.6.833c)

1998

Svendsen, C. N., ter Borg, M. G., Armstrong, R. J., Rosser, A. E., Chandran, S., Ostenfeld, T. and Caldwell, M. A. 1998. A new method for the rapid and long term growth of human neural precursor cells. Journal of Neuroscience Methods 85(2), pp. 141-152. (10.1016/S0165-0270(98)00126-5)
Rosenblatt, A. et al. 1998. Patients with features similar to Huntington's disease, without CAG expansion in huntingtin. Neurology 51(1), pp. 215-220. (10.1212/WNL.51.1.215)
Lawrence, A. D. et al. 1998. Evidence for specific cognitive deficits in preclinical Huntington's disease. Brain 121(7), pp. 1329-1341. (10.1093/brain/121.7.1329)

1997

Svendsen, C. N. et al. 1997. Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Experimental Neurology 148(1), pp. 135-146. (10.1006/exnr.1997.6634)
Watts, C., Dunnett, S. B. and Rosser, A. E. 1997. Effect of embryonic donor age and dissection on the DARPP-32 content of cell suspensions used for intrastriatal transplantation. Experimental Neurology 148(1), pp. 271-280. (10.1006/exnr.1997.6646)
Svendsen, C. N., Skepper, J., Rosser, A. E., ter Borg, M. G., Tyres, P. and Ryken, T. 1997. Restricted growth potential of rat neural precursors as compared to mouse. Brain research. Developmental brain research 99(2), pp. 253-258. (10.1016/S0165-3806(97)00002-3)
Rosser, A. E., Tyers, P., ter Borg, M., Dunnett, S. B. and Svendsen, C. N. 1997. Co-expression of MAP-2 and GFAP in cells developing from rat EGF responsive precursor cells. Brain research. Developmental brain research 98(2), pp. 291-295. (10.1016/S0165-3806(96)00189-7)

1996

Lawrence, A. D., Sahakian, B. J., Hodges, J. R., Rosser, A. E., Lange, K. W. and Robbins, T. W. 1996. Executive and mnemonic functions in early Huntington's disease. Brain 119(5), pp. 1633-1645. (10.1093/brain/119.5.1633)
Svendsen, C., Clarke, D., Rosser, A. E. and Dunnett, S. 1996. Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Experimental Neurology 137(2), pp. 376-388. (10.1006/exnr.1996.0039)
Dunnett, S. B., Annett, L. E., Svendsen, C. N. and Rosser, A. E. 1996. Sources of cells for transplantation and gene therapy in Parkinson's disease. Journal of Neurochemistry 66(2), pp. S52-S52.

1995

Svendsen, C. N. and Rosser, A. E. 1995. Neurones from stem cells?. Trends in Neurosciences 18(11), pp. 465-467. (10.1016/0166-2236(95)90045-4)

1994

Rosser, A. E. and Hodges, J. R. 1994. Initial letter and semantic category fluency in Alzheimer's disease, Huntington's disease, and progressive supranuclear palsy. Journal of Neurology, Neurosurgery & Psychiatry 57(11), pp. 1389-1394. (10.1136/jnnp.57.11.1389)
Rosser, A. E. and Hodges, J. R. 1994. The Dementia Rating Scale in Alzheimer's disease, Huntington's disease and progressive supranuclear palsy. Journal of Neurology 241(9), pp. 531-536. (10.1007/BF00873515)

1991

Dickinson, R. and Rosser, A. E. 1991. Low back pain associated with streptokinase. British Medical Journal (BMJ) 302(6768), pp. 111-112.

1989

Rosser, A. E., Remfry, C. J. and Keverne, E. B. 1989. Restricted exposure of mice to primer pheromones coincident with prolactin surges blocks pregnancy by changing hypothalamic dopamine release. Reproduction 87(2), pp. 553-559. (10.1530/jrf.0.0870553)
Kaba, H., Rosser, A. E. and Keverne, B. 1989. Neural basis of olfactory memory in the context of pregnancy block. Neuroscience 32(3), pp. 657-662. (10.1016/0306-4522(89)90287-X)

1988

Kaba, H., Rosser, A. E. and Keverne, E. 1988. Hormonal enhancement of neurogenesis and its relationship to the duration of olfactory memory. Neuroscience 24(1), pp. 93-98. (10.1016/0306-4522(88)90314-4)

1986

Rosser, A. E., Hokfelt, T. and Goldstein, M. 1986. LHRH and catecholamine neuronal systems in the olfactory bulb of the mouse. The Journal of Comparative Neurology 250(3), pp. 352-363. (10.1002/cne.902500308)

1985

Rosser, A. E. and Keverne, E. 1985. The importance of central noradrenergic neurones in the formation of an olfactory memory in the prevention of pregnancy block. Neuroscience 15(4), pp. 1141-1147. (10.1016/0306-4522(85)90258-1)

1984

Rosser, A. E. and Hokfelt, T. 1984. Luteinizing-hormone-releasing hormone (LHRH) in the mouse olfactory-bulb including some comparisons with distribution of tyrosine-hydroxylase (TH) and dopamine beta-hydroxylase (DBH). Journal of Anatomy 139(DEC), pp. 732-732.
Rosser, A. E. and Keverne, E. 1984. Noradrenergic mechanisms in the olfactory block to pregnancy. Journal of Anatomy 139(DEC), pp. 720-720.

Models of disease

We require valid models of disease in order to evaluate novel treatments. We compare neurochemical, excitotoxic, metabolic and transgenic strategies, both in vitro and in vivo, for their accuracy in reproducing the specific patterns of neuropathology and mechanisms of cell death observed in human disease, and for their reliability in providing stable models within which to compare different treatments strategies.

Neural transplantation

Improving the yield of surviving cells has turned out to be a key factor in viability of neural transplantation in Parkinson's disease, and this is likely to be of equal importance when applied to other neurodegenerative diseases such as Huntington's disease or multiple sclerosis. We are working to refine the methods for neural transplantation into the nervous system to yield optimal survival and growth of the implanted cells. Critical factors involve identification, dissection and handling of embryonic donor cells, and the surgical implantation protocols that maximise accuracy of placement and minimise trauma both to the host and to the implants.

Alternative cells for therapy

The successful clinical trials of transplantation have to date all used embryonic donor tissues. However, whereas surgeries based on using human embryonic tissues can provide a 'proof of principle' the long term development and wider availability of neural transplantation is critically dependent on the identification of more readily available alternative sources of cells. We are actively exploring expanded populations of human stem cells, xenografts, and genetically manipulated cells and cell lines for their ability to provide safer and more readily available alternative to primary embryonic neurones for transplantation.

Neuroprotection

A complementary approach to cell transplantation (which involves replacing cells once already lost) is to protect damaged or traumatised neurones of the host brain from the assault of injury or disease. A wide number of compounds have been identified which have the potential to block processes of cell death and to promote regrowth of damaged cells, including growth factors, antiapoptotic agents, antioxidants and transcription factors. However a common problem for their use is that they don't get into the brain when injected or ingested peripherally. We are developing ways to deliver neuroprotective agents into precise sites in the brain both by engineering cells for transplantation ('ex vivo gene therapy') and by using viral vectors for direct intracerebral delivery ('in vivo gene therapy').

Neurological assessment

The viability of each strategy needs to be evaluated in functional models of the disease. This requires development of behavioural and other functional models of assessment that are both sensitive to the neuroanatomical systems under investigation and relevant to the specific diseases targeted. A key component of our programme is to refine methods of functional analysis according to these dual goals, with a particular focus on objective operant tests of motor and cognitive function.

Grants

MRC (ND Allen, AE Rosser & SB Dunnett
Development of a platform to generate clinical grade neural progenitors for transplantation in Huntington's disease
Newly awarded

UKSCF/MRC Project grant (SB Dunnett & AE Rosser)
Validity, specificity and yields of clinical grade primary and expanded human fetal cells for neural transplantation
£811,379
Feb 2008 – Feb 2011

MRC 5 year project grant (SB Dunnett & AE Rosser)
Development and validation of functional cell therapies for Huntington's and Parkinson's diseases
£1,600,653
Feb 2006 - 2011

Framework 6 EU (Coordinator Dr Marc Peschanski (France), UK partners ND Allen, AE Rosser and AL Jones, Cardiff University)
Stem cells for therapeutics and exploration of mechanisms in Huntington's disease
Nov 2006 – Nov 09

Aland Culture Foundation
Grant to support Huntington's disease research in Cardiff.
£23,935
October 2004 – October 2009

Collaborations

International

Dr Marc Peschanski, INSERM, Creteil, France
Members of NECTAR

Contact Details

RosserAE@cardiff.ac.uk
+44 29208 76654
Sir Martin Evans Building, Room 3.02, Museum Avenue, Cardiff, CF10 3AX

Landmark research in Huntington’s disease

09 January 2018

External profiles

ORCID

Professor Anne Rosser PhD, FRCP

Overview