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Overview
Prof. Jamie Rossjohn, FAA FLSW FMedSci
My research is centered on an understanding immunity.
I am currently an ARC Australian Laureate Fellow (2017-2021) and previously a NHMRC Australia Fellow (2011-2016) and ARC Federation Fellow (2007-11). I am a Professor of Structural Immunology at Cardiff University and the Head of the Infection and Immunity Program of the Biomedicine Discovery Institute at Monash University.
I am known for my contributions to the understanding the molecular basis underpinning immunity. I have used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. I have unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. I have pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. Recently my team has provided a structural basis of how vitamin B metabolites can be presented and recognised by the immune system, revealing a new class of antigen.
Collectively, I have published > 350 papers and mentored numerous researchers towards obtaining higher degrees and nationally competitive fellowships.
Publication
2024
- Samer, C. et al. 2024. Impaired endocytosis and accumulation in early endosomal compartments defines herpes simplex virus–mediated disruption of the nonclassical MHC class I–related molecule MR1. Journal of Biological Chemistry 300(10), article number: 107748. (10.1016/j.jbc.2024.107748)
- Gully, B. S. et al. 2024. Structure of a fully assembled γδ T cell antigen receptor. Nature 634(8034), pp. 729-736. (10.1038/s41586-024-07920-0)
- Almeida, C. F. et al. 2024. Direct recognition of an intact foreign protein by an αβ T cell receptor. Nature Communications 15, article number: 8816. (10.1038/s41467-024-51897-3)
- Hayday, A., Dechanet-Merville, J., Rossjohn, J. and Silva-Santos, B. 2024. Cancer immunotherapy by γδ T cells. Science 386(6717), article number: eabq7248. (10.1126/science.abq7248)
- Cornforth, T. V. et al. 2024. Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs. Frontiers in Oncology 14, article number: 1419528. (10.3389/fonc.2024.1419528)
- Rowntree, L. C. et al. 2024. SARS-CoV-2-specific CD8+ T cells from people with long COVID establish and maintain effector phenotype and key TCR signatures over 2 years. Proceedings of the National Academy of Sciences 121(39), article number: e2411428121. (10.1073/pnas.2411428121)
- Cao, T., Shahine, A., Cox, L. R., Besra, G. S., Moody, D. B. and Rossjohn, J. 2024. A structural perspective of how T cell receptors recognize the CD1 family of lipid antigen-presenting molecules. Journal of Biological Chemistry 300(8), article number: 107511. (10.1016/j.jbc.2024.107511)
- Braun, A. et al. 2024. Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes. Nature Communications 15(1), article number: 7547. (10.1038/s41467-024-51959-6)
- Jia, X. et al. 2024. High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases. Cell 187(17), pp. 4586-4604. (10.1016/j.cell.2024.07.026)
- Loh, T. J. et al. 2024. The molecular basis underlying T cell specificity towards citrullinated epitopes presented by HLA-DR4. Nature Communications 15(1), article number: 6201. (10.1038/s41467-024-50511-w)
- Tandori, E., Ciacchi, L., Ciacchi, L., Ly‐Huynh, J. D., Favilla, S. and Rossjohn, J. 2024. Access all areas: multisensory science exhibitions tailored toward blind, low‐vision and diverse‐needs communities. Immunology & Cell Biology 102(5), pp. 321-325. (10.1111/imcb.12738)
- MacLachlan, B. J., Sullivan, L. C., Brooks, A. G., Rossjohn, J. and Vivian, J. P. 2024. Structure of the murine CD94–NKG2A receptor in complex with Qa-1b presenting an MHC-I leader peptide. The FEBS Journal 291(7), pp. 1530-1544. (10.1111/febs.17050)
- Menon, T. et al. 2024. CD8 + T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age. Nature Communications 15, article number: 3387. (10.1038/s41467-024-47576-y)
- Samer, C. et al. 2024. Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection. iScience 27(2), article number: 108801. (10.1016/j.isci.2024.108801)
2023
- Zhang, W. et al. 2023. Broad spectrum SARS‐CoV ‐2‐specific immunity in hospitalized First Nations peoples recovering from COVID ‐19. Immunology & Cell Biology 101(10), pp. 964-974. (10.1111/imcb.12691)
- Lameris, R. et al. 2023. Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions. Journal for ImmunoTherapy of Cancer 11, article number: e007631. (10.1136/jitc-2023-007631)
- van de Sandt, C. E. et al. 2023. Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan. Nature Immunology 24, pp. 1890–1907. (10.1038/s41590-023-01633-8)
- Huang, S. et al. 2023. CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms. Cell 186(21), pp. 4583-4596. (10.1016/j.cell.2023.08.022)
- Shahine, A., Van Rhijn, I., Rossjohn, J. and Moody, D. B. 2023. CD1 displays its own negative regulators. Current Opinion in Immunology 83, article number: 102339. (10.1016/j.coi.2023.102339)
- Zhao, Y. et al. 2023. DeepAIR: A deep learning framework for effective integration of sequence and 3D structure to enable adaptive immune receptor analysis. Science Advances 9(32) (10.1126/sciadv.abo5128)
- Anand, S. et al. 2023. Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02. Journal of Biological Chemistry 299(7), article number: 104930. (10.1016/j.jbc.2023.104930)
- Mifsud, N. A. et al. 2023. The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug‐reactive T cells in resolved hypersensitivity cases and drug‐naïve healthy donors. Allergy (10.1111/all.15814)
- Zhang, W. et al. 2023. Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities. Nature Immunology 24(6), pp. 966-978. (10.1038/s41590-023-01508-y)
- Ciacchi, L. et al. 2023. CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity. Immunity 56(5), pp. 1082-1097. (10.1016/j.immuni.2023.03.020)
- Nguyen, T. H. et al. 2023. Robust SARS-CoV-2 T cell responses with common TCR?? motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells. Cell Reports Medicine 4(4), article number: 101017. (10.1016/j.xcrm.2023.101017)
- Koutsakos, M. et al. 2023. SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses. Immunity 56(4), pp. 879-892. (10.1016/j.immuni.2023.02.017)
- Pan, Y., Chandrashekaran, I. R., Tennant, L., Rossjohn, J. and Littler, D. R. 2023. Inside-out: antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9. PLoS ONE 18(4), article number: e0283194. (10.1371/journal.pone.0283194)
- Farquhar, R., Van Rhijn, I., Moody, D. B., Rossjohn, J. and Shahine, A. 2023. αβ T cell receptor recognition of self-phosphatidylinositol presented by CD1b. Journal of Biological Chemistry 299(2), article number: 102849. (10.1016/j.jbc.2022.102849)
- von Borstel, A. et al. 2023. Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals. Immunology & Cell Biology (10.1111/imcb.12623)
- Ashley, C. L. et al. 2023. Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation. Frontiers in Immunology 14 (10.3389/fimmu.2023.1107497)
- Purohit, S. K. et al. 2023. Varicella zoster virus impairs expression of the nonclassical major histocompatibility complex class I-related gene protein (MR1). The Journal of Infectious Diseases 227(3), pp. 391-401. (10.1093/infdis/jiab526)
- Monnot, G. C. et al. 2023. Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a. Nature Immunology 24(1), pp. 110-122. (10.1038/s41590-022-01375-z)
2022
- Wang, C. J. et al. 2022. Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I–related protein 1 MR1. Journal of Biological Chemistry 298(12), article number: 102714. (10.1016/j.jbc.2022.102714)
- Hardman, C. S. et al. 2022. CD1a promotes systemic manifestations of skin inflammation. Nature Communications 13, article number: 7535. (10.1038/s41467-022-35071-1)
- Sonigra, A. et al. 2022. Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis. JCI Insight 7(20), article number: e160964. (10.1172/jci.insight.160964)
- Rowntree, L. C. et al. 2022. SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection. Immunity 55(7), pp. 1299-1315. (10.1016/j.immuni.2022.06.003)
- Wegrecki, M. et al. 2022. Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors. Nature Communications 13(1), article number: 3872. (10.1038/s41467-022-31443-9)
- Sakari, M., Tran, M. T., Rossjohn, J., Pulliainen, A. T., Beddoe, T. and Littler, D. R. 2022. Crystal structures of pertussis toxin with NAD+ and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. Journal of Biological Chemistry 298(5), article number: 101892. (10.1016/j.jbc.2022.101892)
- McMurray, J. L. et al. 2022. Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program. Cell Reports 39(8), article number: 110858. (10.1016/j.celrep.2022.110858)
- Zhang, W. et al. 2022. Robust and prototypical immune responses towards COVID-19 BNT162b2 vaccines in Indigenous people. The Journal of Immunology 208(1_Supp), article number: 65.13. (10.4049/jimmunol.208.Supp.65.13)
- Meeuwsen, M. H. et al. 2022. Cutting Edge: Unconventional CD8+ T Cell Recognition of a Naturally Occurring HLA-A*02:01?Restricted 20mer Epitope. Journal of Immunology 208(8), pp. 1851-1856. (10.4049/jimmunol.2101208)
- Ciacchi, L., Farenc, C., Dahal-Koirala, S., Petersen, J., Sollid, L. M., Reid, H. H. and Rossjohn, J. 2022. Structural basis of T cell receptor specificity and cross-reactivity of two HLA-DQ2.5-restricted gluten epitopes in celiac disease. Journal of Biological Chemistry 298(3), article number: 101619. (10.1016/j.jbc.2022.101619)
- Suliman, S. et al. 2022. Dual TCR-α expression on mucosal-associated invariant T cells as a potential confounder of TCR interpretation. Journal of Immunology 208(6), pp. 1389-1395. (10.4049/jimmunol.2100275)
- Habel, J. R. et al. 2022. HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people. PLoS Pathogens 18(3), article number: e1010337. (10.1371/journal.ppat.1010337)
2021
- Littler, D. R. et al. 2021. A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein. Journal of Biological Chemistry 297(6), article number: 101362. (10.1016/j.jbc.2021.101362)
- Oh, S. F. et al. 2021. Host immunomodulatory lipids created by symbionts from dietary amino acids. Nature 600(7888), pp. 302–307. (10.1038/s41586-021-04083-0)
- Reijneveld, J. F. et al. 2021. Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. Journal of Biological Chemistry 297(4), article number: 101197. (10.1016/j.jbc.2021.101197)
- Rowntree, L. C. et al. 2021. SARS-CoV-2-specific CD8+ T-cell responses and TCR signatures in the context of a prominent HLA-A*24:02 allomorph. Immunology & Cell Biology 99(9), pp. 990-1000. (10.1111/imcb.12482)
- Littler, D. R. et al. 2021. Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9. Journal of Biological Chemistry 297(3), article number: 101018. (10.1016/j.jbc.2021.101018)
- Chaurasia, P. et al. 2021. Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein. Journal of Biological Chemistry 297(3), article number: 101065. (10.1016/j.jbc.2021.101065)
- Gully, B. S., Rossjohn, J. and Davey, M. S. 2021. Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity. Biochemical Society Transactions (10.1042/BST20200890)
- Mayassi, T., Barreiro, L. B., Rossjohn, J. and Jabri, B. 2021. A multilayered immune system through the lens of unconventional T cells. Nature 595, pp. 501-510. (10.1038/s41586-021-03578-0)
- Zhao, Z. et al. 2021. Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection. Nature Communications 12, article number: 4355. (10.1038/s41467-021-24570-2)
- Hensen, L. et al. 2021. CD8+ T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph. Nature Communications 12(1), article number: 2931. (10.1038/s41467-021-23212-x)
- Nguyen, T. H. et al. 2021. CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity. Immunity 54(5), pp. 1066-1082. (10.1016/j.immuni.2021.04.009)
- Nguyen, T. H. O. et al. 2021. Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients. Nature Communications 12(1), article number: 2691. (10.1038/s41467-021-23018-x)
- Mifsud, N. A. et al. 2021. Carbamazepine induces focused T cell responses in resolved Stevens-Johnson syndrome and toxic epidermal necrolysis cases but does not perturb the immunopeptidome for T cell recognition. Frontiers in Immunology 12, article number: 653710. (10.3389/fimmu.2021.653710)
- Moradi, S. et al. 2021. Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nature Communications 12(1), article number: 2173. (10.1038/s41467-021-22359-x)
- Howson, L. J. et al. 2021. Mucosal-associated invariant T cell effector function is an intrinsic cell property that can be augmented by the metabolic cofactor α-Ketoglutarate. Journal of Immunology 206(7), pp. 1425-1435. (10.4049/jimmunol.2001048)
- Saunders, P. M. et al. 2021. The role of the HLA class I α2 helix in determining ligand hierarchy for the killer cell Ig-like receptor 3DL1. Journal of Immunology 206(4), pp. 849-860. (10.4049/jimmunol.2001109)
- Wirasinha, R. C. et al. 2021. Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility. Journal of Experimental Medicine 218(2), article number: e20200476. (10.1084/jem.20200476)
- Cotton, R. N. et al. 2021. Human skin is colonized by T cells that recognize CD1a independently of lipid. Journal of Clinical Investigation 131(1), article number: e140706. (10.1172/JCI140706)
2020
- McWilliam, H. E. G. et al. 2020. Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens. Proceedings of the National Academy of Sciences 117(40), pp. 24974-24985. (10.1073/pnas.2011260117)
- Assmus, L. M. et al. 2020. Overlapping peptides elicit distinct CD8+ T cell responses following Influenza A virus infection. Journal of Immunology 205(7), pp. 1731-1742. (10.4049/jimmunol.2000689)
- Habel, J. R. et al. 2020. Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype. Proceedings of the National Academy of Sciences 117(39), pp. 24384-24391. (10.1073/pnas.2015486117)
- Suliman, S. et al. 2020. Peripheral blood mucosal-associated invariant T Cells in tuberculosis patients and healthy mycobacterium tuberculosis-exposed controls. Journal of Infectious Diseases 222(6), pp. 995-1007. (10.1093/infdis/jiaa173)
- Rowntree, L. C. et al. 2020. A shared TCR bias toward an immunogenic EBV epitope dominates in HLA-B*07:02–expressing individuals. Journal of Immunology 205(6), pp. 1524-1534. (10.4049/jimmunol.2000249)
- Aguilar, O. A., Tanaka, M., Balaji, G. R., Berry, R., Rossjohn, J., Lanier, L. L. and Carlyle, J. R. 2020. Tetramer immunization and selection followed by CELLISA screening to generate monoclonal antibodies against the mouse cytomegalovirus m12 immunoevasin. Journal of Immunology 205(6), pp. 1709-1717. (10.4049/jimmunol.2000687)
- Reijneveld, J. F. et al. 2020. Human γδ T cells recognize CD1b by two distinct mechanisms. Proceedings of the National Academy of Sciences 117(37), pp. 22933-22952. (10.1073/pnas.2010545117)
- Lameris, R. et al. 2020. A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response. Nature Cancer 1(11), pp. 1054-1065. (10.1038/s43018-020-00111-6)
- Schultz-Cherry, S. et al. 2020. HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells. PLoS Pathogens 16(8), article number: e1008714. (10.1371/journal.ppat.1008714)
- Junghans, V. et al. 2020. Effects of a local auxiliary protein on the two-dimensional affinity of a TCR–peptide MHC interaction. Journal of Cell Science 133(15), article number: jcs245985. (10.1242/jcs.245985)
- Littler, D. R., Gully, B. S., Colson, R. N. and Rossjohn, J. 2020. Crystal structure of the SARS-CoV-2 non-structural protein 9, Nsp9. iScience 23(7), article number: 101258. (10.1016/j.isci.2020.101258)
- Toubal, A. et al. 2020. Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity. Nature Communications 11(1), article number: 3755. (10.1038/s41467-020-17307-0)
- Howson, L. J. et al. 2020. Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1. Science Immunology 5(49), article number: eabc9492. (10.1126/sciimmunol.abc9492)
- Saunders, P. M. et al. 2020. The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function. Proceedings of the National Academy of Sciences 117(21), pp. 11636-11647. (10.1073/pnas.1920570117)
- Awad, W. et al. 2020. The molecular basis underpinning the potency and specificity of MAIT cell antigens. Nature Immunology 21(4), pp. 400-411. (10.1038/s41590-020-0616-6)
- Salio, M. et al. 2020. Ligand-dependent downregulation of MR1 cell surface expression. Proceedings of the National Academy of Sciences 117(19), pp. 10465-10475. (10.1073/pnas.2003136117)
- Fugger, L., Jensen, L. T. and Rossjohn, J. 2020. Challenges, progress, and prospects of developing therapies to treat autoimmune diseases. Cell 181(1), pp. 63-80. (10.1016/j.cell.2020.03.007)
- McSharry, B. P. et al. 2020. Virus-mediated suppression of the antigen presentation Molecule MR1. Cell Reports 30(9), pp. 2948-2962e4. (10.1016/j.celrep.2020.02.017)
- Loh, L. et al. 2020. Human mucosal-associated invariant T cells in older individuals display expanded TCRαβ clonotypes with potent antimicrobial responses. Journal of Immunology 204(5), pp. 1119-1133. (10.4049/jimmunol.1900774)
- Crowther, M. D. et al. 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21, pp. 178 - 185. (10.1038/s41590-019-0578-8)
- Berry, R., Watson, G. M., Jonjic, S., Degli-Esposti, M. A. and Rossjohn, J. 2020. Modulation of innate and adaptive immunity by cytomegaloviruses. Nature Reviews Immunology 20, pp. 113-127. (10.1038/s41577-019-0225-5)
- Rowntree, L. C. et al. 2020. Preferential HLA-B27 allorecognition displayed by multiple cross-reactive antiviral CD8+ T cell receptors. Frontiers in Immunology 11, article number: 248. (10.3389/fimmu.2020.00248)
- Ting, Y. T. et al. 2020. A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease. Proceedings of the National Academy of Sciences 117(6), pp. 3063-3073. (10.1073/pnas.1914308117)
- Petersen, J. et al. 2020. T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease. Nature Structural and Molecular Biology 27(1), pp. 49-61. (10.1038/s41594-019-0353-4)
- Nicolai, S. et al. 2020. Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products. Science Immunology 5(43), article number: eaax5430. (10.1126/sciimmunol.aax5430)
2019
- Chen, Z. et al. 2019. Characterization and purification of mouse mucosal-associated invariant T (MAIT) cells. Current Protocols in Immunology 127(1), article number: e89. (10.1002/cpim.89)
- Souter, M. N. et al. 2019. Characterization of Human Mucosal-associated Invariant T (MAIT) cells. Current Protocols in Immunology 127(1), article number: e90. (10.1002/cpim.90)
- Picarda, E. et al. 2019. Cross-reactive donor-specific CD8+ Tregs efficiently prevent transplant rejection. Cell Reports 29(13), pp. 4245-4255.e6. (10.1016/j.celrep.2019.11.106)
- Le Nours, J. et al. 2019. A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1. Science 366(6472), pp. 1522-1527. (10.1126/science.aav3900)
- Reinink, P. et al. 2019. A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins. Journal of Immunology 203(12), pp. 3395-3046. (10.4049/jimmunol.1900872)
- van de Sandt, C. E. et al. 2019. Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph. Nature Communications 10(1), article number: 5579. (10.1038/s41467-019-13346-4)
- Almeida, C. F. et al. 2019. Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors. Nature Communications 10(1), article number: 5242. (10.1038/s41467-019-12941-9)
- Lim Kam Sian, T. C. C. et al. 2019. Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation. Journal of Biological Chemistry 294(52), pp. 20185-20195. (10.1074/jbc.RA119.010257)
- Wang, H. et al. 2019. IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection. Science Immunology 4(41), article number: eaaw0402. (10.1126/sciimmunol.aaw0402)
- Deuss, F. A. et al. 2019. Structural basis for the recognition of nectin-like protein-5 by the human-activating immune receptor, DNAM-1. Journal of Biological Chemistry 294(33), pp. 12534-12546. (10.1074/jbc.RA119.009261)
- Niehrs, A. et al. 2019. A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44. Nature Immunology 20(9), pp. 1129-1137. (10.1038/s41590-019-0448-4)
- Schinkelshoek, M. et al. 2019. H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls. Journal of Neuroimmunology 332, pp. 167-175. (10.1016/j.jneuroim.2019.04.009)
- Koutsakos, M. et al. 2019. Downregulation of MHC class I expression by influenza A and B viruses. Frontiers in Immunology 10, pp. -., article number: 1158. (10.3389/fimmu.2019.01158)
- Koutsakos, M. et al. 2019. Human CD8+ T cell cross-reactivity across influenza A, B and C viruses. Nature Immunology 20, pp. 613-625. (10.1038/s41590-019-0320-6)
- Dey, S. et al. 2019. A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells. Sensors and Actuators B: Chemical 284, pp. 281-288. (10.1016/j.snb.2018.12.099)
- Mayassi, T. et al. 2019. Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease. Cell 176(5), pp. 967-981.e19. (10.1016/j.cell.2018.12.039)
- Neier, S. C. et al. 2019. The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network. Science Immunology 4(32), article number: eaal2201. (10.1126/sciimmunol.aal2201)
- Dahal-Koirala, S. et al. 2019. Discriminative T-cell receptor recognition of highly homologous HLA-DQ2–bound gluten epitopes. Journal of Biological Chemistry 294(3), pp. 941-952. (10.1074/jbc.RA118.005736)
- Shahine, A. et al. 2019. A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids. Nature Communications 10(1), pp. -., article number: 56. (10.1038/s41467-018-07898-0)
- Ooi, J. D. et al. 2019. A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity. Nature Communications 10(1), article number: 3392. (10.1038/s41467-019-11255-0)
2018
- Grant, E. J. et al. 2018. Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans. Nature Communications 9(1), pp. -., article number: 5427. (10.1038/s41467-018-07815-5)
- Gherardin, N. A., McCluskey, J., Rossjohn, J. and Godfrey, D. I. 2018. The diverse family of MR1-restricted T cells. The Journal of Immunology 201(10), pp. 2862-2871. (10.4049/jimmunol.1801091)
- Illing, P. T. et al. 2018. HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome. Nature Communications 9(1), article number: 4693. (10.1038/s41467-018-07109-w)
- Balaji, G. R. et al. 2018. Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition. Nature Communications 9(1), article number: 4623. (10.1038/s41467-018-06989-2)
- Faridi, P. et al. 2018. A subset of HLA-I peptides are not genomically templated: evidence for cis- and trans-spliced peptide ligands. Science Immunology 3(28), article number: eaar3947. (10.1126/sciimmunol.aar3947)
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2016
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2014
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2013
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- Liu, Y. et al. 2013. Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule. Journal of Biological Chemistry 288(22), pp. 15442-15454. (10.1074/jbc.M112.447185)
- Berry, R. et al. 2013. Targeting of a natural killer cell receptor family by a viral immunoevasin. Nature Immunology 14(7), pp. 699-705. (10.1038/ni.2605)
- Valkenburg, S. et al. 2013. Preemptive priming readily overcomes structure-based mechanisms of virus escape. Proceedings of the National Academy of Sciences of the United States of America 110(14), pp. 5570-5575. (10.1073/pnas.1302935110)
- Ladell, K. I. et al. 2013. A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38(3), pp. 425-436. (10.1016/j.immuni.2012.11.021)
- Eukeruche-Makinde, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood -New York- 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Ekeruche, J. et al. 2013. Peptide length determines the outcome of TCR/peptide-MHCI engagement. Blood 121(7), pp. 1112-1123. (10.1182/blood-2012-06-437202)
- Illing, P. T., Vivan, J. P., Rossjohn, J. and McCluskey, J. 2013. Human leukocyte antigen-associated drug hypersensitivity [review]. Current Opinion in Immunology 25(1), pp. 81-89. (10.1016/j.coi.2012.10.002)
- Vavassori, S. et al. 2013. Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. Nature Immunology 14(9), pp. 908-916. (10.1038/ni.2665)
- Uldrich, A. et al. 2013. CD1d-lipid antigen recognition by the γδTCR. Nature Immunology 14(11), pp. 1137-1145. (10.1038/ni.2713)
- Patel, O. et al. 2012. Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nature Immunology 13(9), pp. 857-863. (10.1038/ni.2372)
- Bulek, A. et al. 2012. Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes. Nature Immunology 13(3), pp. 283-289. (10.1038/ni.2206)
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Book sections
- Eckle, S. B. G., Rossjohn, J. and McCluskey, J. 2013. Alloreactivity. In: Zachary, A. A. and Leffell, M. S. eds. Transplantation Immunology., Vol. 1034. Methods in Molecular Biology Springer, pp. 3-39., (10.1007/978-1-62703-493-7_1)
- Brennan, P. J. et al. 2017. Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface. Proceedings of the National Academy of Sciences of the United States of America 114(31), pp. 8348-8353. (10.1073/pnas.1705882114)
Research
Current projects:
The academic research program within this laboratory is focused on defining the key molecular interactions underlying receptor recognition events that are the primary determinants of immunity.
1) Investigating lipid-based immunity in the context of Mycobacterium tuberculosis infection.
2) Investigating the role of lipids in skin-based allergies (e.g. contact hypersensitivities).
3) A chemical/biochemical study into vitamin B metabolite recognition.
4) Investigating T cell mediated autoimmunity (e.g. Celiac Disease).
Our research program uses numerous biochemical and biophysical techniques including protein expression and purification, surface plasmon resonance and three-dimensional structure determination with the use of the Australian Synchrotron. Further, cellular immunology techniques are taught within the laboratories of the collaborators of the Rossjohn laboratory. The industrial research program of the laboratory includes a close collaboration with Janssen, for the development of new therapies to treat psoriasis and rheumatoid arthritis.
Successful funding applications:
The laboratory is funded by the National Health & Medical Research Council (NHMRC), the Australian Research Council (ARC), the ARC Centre of Excellence in Advanced Molecular Imaging, Cancer Council Victoria, National Institutes of Health, Worldwide Cancer Research and Janssen.
Recent research impacts:
http://faobmb.com/2017/07/26/winner-of-faobmb-award-for-research-excellence-2017/
http://www.afr.com/news/janssen-biotech-funds-monash-rheumatoid-arthritis-research-20170601-gwibpz
