Dr Barbara Szomolay

2024

• Triantafilou, K., Szomolay, B., Shepherd, M. W., Ramanjulu, J. and Triantafilou, M. 2024. STING orchestrates EV-D68 replication and immunometabolism within viral-induced replication organelles. Viruses 16(10), article number: 1541. (10.3390/v16101541)
• Livkisa, D., Lee, T., Yeh, W., Jaimes, M. S., Szomolay, B., Liao, C. and Lundy, D. J. 2024. Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages. Immunity and Ageing 21, article number: 72. (10.1186/s12979-024-00472-x)
• Dolton, G. et al. 2024. HLA A*24:02-restricted T-cell receptors cross recognise bacterial and preproinsulin peptides in type 1 diabetes. Journal of Clinical Investigation 134(18), article number: e164535. (10.1172/JCI164535)
• Pratt, H. G. et al. 2024. Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma. Clinical and Translational Medicine 14(3), article number: e1595. (10.1002/ctm2.1595)
• Lundy, D. J., Szomolay, B. and Liao, C. 2024. Systems approaches to cell culture-derived extracellular vesicles for acute kidney injury therapy: Prospects and challenges. Function 5(3), article number: zqae012. (10.1093/function/zqae012)

2023

• Tripodi, L. et al. 2023. Bifidobacterium affects antitumor efficacy of oncolytic adenovirus in a mouse model of melanoma. iScience 26(10), article number: 107668. (10.1016/j.isci.2023.107668)
• Dolton, G. et al. 2023. Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy. Cell 186(16), pp. 3333-3349., article number: E27. (10.1016/j.cell.2023.06.020)
• Millrine, D. et al. 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211(2), pp. 274-286. (10.4049/jimmunol.2300114)
• Dewhurst, H., Boktor, J., Szomolay, B. and Lewis, P. 2023. Patient-reported outcomes in 1,079 uncemented total hip arthroplasties: a prospective 10-year case series. Presented at: The Welsh Orthopaedic Society Meeting, Newport, Wales, 26-27 May 2023, Vol. 105-B. Vol. S4. British Editorial Society of Bone and Joint Surgery pp. 12-12., (10.1302/1358-992X.2023.4.012)
• Tripodi, L. et al. 2023. Systems biology approaches for the improvement of oncolytic virus-based immunotherapies. Cancers 15(4), article number: 1297. (10.3390/cancers15041297)

2022

• Guest, K., Whalley, T., Maillard, J., Artemiou, A., Szomolay, B. and Webber, M. A. 2022. Responses of Salmonella biofilms to oxidizing biocides: evidence of spatial clustering. Environmental Microbiology 24(12), pp. 6426-6438. (10.1111/1462-2920.16263)
• Martins dos Santos, V. et al. 2022. Systems Biology in ELIXIR: modelling in the spotlight. F1000Research 11, article number: 1265. (10.12688/f1000research.126734.1)
• Dolton, G. et al. 2022. Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope. Cell 185(16), pp. 2936-2951. (10.1016/j.cell.2022.07.002)
• Czarnewski, P. et al. 2022. Community-driven ELIXIR activities in single-cell omics. F1000Research 11, article number: 869. (10.12688/f1000research.122312.1)
• Chimbola, O. M., Lungu, E. M. and Szomolay, B. 2022. Optimal control application to a Kaposi’s sarcoma treatment model. International Journal of Biomathematics 15(1), article number: 2150081. (10.1142/S1793524521500819)

2021

• Pratt, H. G. et al. 2021. Macrophage and neutrophil interactions in the pancreatic tumor microenvironment drive the pathogenesis of pancreatic cancer. Cancers 14(1), article number: 194. (10.3390/cancers14010194)
• Lu, Y. et al. 2021. Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis. Journal of the American Society of Nephrology 32(10), pp. 2501-2516. (10.1681/ASN.2020081143)
• Chiaro, J. et al. 2021. Viral molecular mimicry influences the antitumor immune response in murine and human melanoma. Cancer Immunology Research 9(8), pp. 981-983. (10.1158/2326-6066.CIR-20-0814)
• Chimbola, O. M., Lungu, E. M. and Szomolay, B. 2021. Effect of innate and adaptive immune mechanisms on treatment regimens in an AIDS-related Kaposi's Sarcoma model. Journal of Biological Dynamics 15(1), pp. 213-249. (10.1080/17513758.2021.1912420)
• Kaondera-Shava, R. F., Lungu, E. and Szomolay, B. 2021. A novel mathematical model of AIDS-associated Kaposi's sarcoma: Analysis and optimal control. BioSystems 200, article number: 104318. (10.1016/j.biosystems.2020.104318)

2020

• Crowther, M. D. et al. 2020. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1. Nature Immunology 21, pp. 178 - 185. (10.1038/s41590-019-0578-8)
• Whalley, T. et al. 2020. GPU-accelerated discovery of pathogen-derived molecular mimics of a T-cell insulin epitope. Frontiers in Immunology 11, article number: 296. (10.3389/fimmu.2020.00296)

2019

• MacLachlan, B. J. et al. 2019. Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope. Journal of Biological Chemistry 294(52), pp. 20246-20258. (10.1074/jbc.RA119.009437)
• Twohig, J. P. et al. 2019. Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. Nature Immunology 20, pp. 458-470. (10.1038/s41590-019-0350-0)
• Galloway, S. A. E. et al. 2019. Peptide super-agonist enhances T-cell responses to melanoma. Frontiers in Immunology 10, article number: 319. (10.3389/fimmu.2019.00319)

2018

• Tungatt, K. et al. 2018. Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig. PLoS Pathogens 14(5), article number: e1007017. (10.1371/journal.ppat.1007017)
• Rius, C. et al. 2018. Peptide-MHC class 1 tetramers can fail to detect relevant functional T cell clonotypes and underestimate antigen-reactive T cell populations. Journal of Immunology 200(7), pp. 2263-2279. (10.4049/jimmunol.1700242)

2017

• Donia, M. et al. 2017. PD-1+ polyfunctional T cells dominate the periphery after tumour-infiltrating lymphocyte therapy for cancer. Clinical Cancer Research 23(19), pp. 5779-5788. (10.1158/1078-0432.CCR-16-1692)

2016

• Szomolay, B. et al. 2016. Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors. Immunology and Cell Biology 94(6), pp. 573-582. (10.1038/icb.2016.12)
• Cole, D. K. et al. 2016. Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity. Journal of Clinical Investigation 126(6), pp. 2191-2204. (10.1172/JCI85679)

2015

• Szomolay, B. and Cogan, N. G. 2015. Modelling mechanical and chemical treatment of biofilms with two phenotypic resistance mechanisms. Environmental Microbiology 17(6), pp. 1870-1883. (10.1111/1462-2920.12710)

2014

• Szomolay, B. and van den Berg, H. A. 2014. Modulation of T-cell receptor functional sensitivity via the opposing actions of protein tyrosine kinases and phosphatases: a mathematical model. Integrative Biology 6(12), pp. 1183-1195. (10.1039/C4IB00190G)
• Szomolay, B., Dockree, T., Wooldridge, L. and van den Berg, H. A. 2014. Corrigendum: co-Receptor CD8-mediated modulation of T-Cell receptor functional sensitivity and epitope recognition degeneracy. Frontiers in Immunology 5, pp. 1-3., article number: 443. (10.3389/fimmu.2014.00443)
• Szomolay, B. and Lungu, E. M. 2014. A mathematical model for the treatment of AIDS-related Kaposi's sarcoma. Journal of Biological Systems 22(3), pp. 495-522. (10.1142/S0218339014500247)

2013

• Szomolay, B., Dockree, T., Wooldridge, L. and Van Den Berg, H. A. 2013. Co-receptor CD8-mediated modulation of T-cell receptor functional sensitivity and epitope recognition degeneracy. Frontiers in Immunology 4, pp. 1-11. (10.3389/fimmu.2013.00329)