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Professor Ian Weeks
- Media commentator
Teams and roles for Ian Weeks
Emeritus Professor
Overview
Research and development of in vitro diagnostic methods based on ligand binding assays such as immunoassay, nucleic acid hybridisation assay and enzymological assay using high sensitivity end-points such as chemiluminescence. Particular emphasis on development of simple, non-invasive methods as alternatives to invasive clinical test procedures. Current research involves the application of the principles outlined above for the development of diagnostic tests for biomarkers of inflammation and cancer.
The overarching strategic model for the research is to target areas where there is an unmet clinical need or where synergy of technologies can enhance clinical diagnosis and management of underlying pathologies. Such a strategy is beneficial to patients and cost-effective for the healthcare provider.
Publication
2023
- Bullock, N. et al. 2023. Perception of urinary biomarker tests among patients referred with suspected urological malignancy. BJUI Compass (10.1002/bco2.234)
2021
- Moat, S. J. et al. 2021. Development of a high throughput SARS-CoV-2 antibody testing pathway using dried blood spot specimens. Annals of Clinical Biochemistry 58 (2)(10.1177/0004563220981106)
2019
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9 (1) 19694. (10.1038/s41598-019-55523-x)
2018
- Cuff, S. et al. 2018. An improved cell-permeable fluorogenic substrate as the basis for a highly sensitive test for NAD(P)H quinone oxidoreductase 1 (NQO1) in living cells. Free Radical Biology and Medicine 116 , pp.141-148. (10.1016/j.freeradbiomed.2018.01.009)
2017
- Moat, S. et al. 2017. Characterization of a blood spot creatine kinase skeletal muscle isoform immunoassay for high-throughput newborn screening of duchenne muscular dystrophy. Clinical Chemistry 63 (4), pp.908-914. (10.1373/clinchem.2016.268425)
- Morris, C. A. et al. 2017. Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicology in Vitro 39 , pp.15-28. (10.1016/j.tiv.2016.11.004)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92 (1), pp.179-191. (10.1016/j.kint.2017.01.017)
2013
- Weeks, I. , Kricka, L. J. and Wild, D. 2013. Signal generation and detection systems (excluding homogeneous assays). In: Wild, D. ed. The Immunoassay Handbook. Elsevier. , pp.267-285. (10.1016/B978-0-08-097037-0.00018-X)
2012
- Browne, K. A. et al., 2012. Spectrally resolved chemiluminescent probes for sensitive multiplex molecular quantification. Analytical Chemistry 84 (21), pp.9222-9229. (10.1021/ac3017423)
- Morris, C. et al. 2012. Utilising chemiluminescent methods for 'animal-free' toxicology tests [Abstract]. Toxicology Letters 211 (Supp.), pp.S104-S105. (10.1016/j.toxlet.2012.03.390)
2011
- Browne, K. A. et al., 2011. Simultaneous quantification of multiple nucleic acid targets using chemiluminescent probes. Journal of the American Chemical Society 133 (37), pp.14637-14648. (10.1021/ja202221h)
2009
- Brown, R. C. et al., 2009. Development and application of a novel acridinium ester for use as a chemiluminescent emitter in nucleic acid hybridisation assays using chemiluminescence quenching. Organic and Biomolecular Chemistry 7 (2), pp.386-394. (10.1039/b811947c)
- Smith, K. et al. 2009. Synthesis and properties of novel chemiluminescent biological probes: 2- and 3-(2-Succinimidyloxycarbonylethyl)phenyl acridinium esters. Journal of Photochemistry and Photobiology A: Chemistry 203 (1), pp.72-79. (10.1016/j.jphotochem.2008.12.020)
2008
- Morris, C. et al. 2008. Comparison of transcription-mediated amplification and growth-based methods for the quantitation of Enterococcus bacteria in environmental waters. Applied and Environmental Microbiology 74 (10), pp.3319-3320. (10.1128/AEM.02623-07)
- Walkley, N. et al. 2008. Investigation of transcription-mediated amplification as a rapid test method for Enterococci in recreational water. Journal of Environmental Monitoring 10 (9), pp.1064-1068. (10.1039/b810284h)
2000
- Smith, K. et al. 2000. Synthesis and properties of novel chemiluminescent biological probes: substituted 4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium-9-carboxylate trifluoromethanesulphonate. Journal of Photochemistry and Photobiology A: Chemistry 132 (3), pp.181-191. (10.1016/S1010-6030(00)00209-4)
1998
- Cheikh, A. B. et al., 1998. Labeled hybridization assay probes useful for the detection and quantification of multiple nucleic acid sequences. US5840873A[Patent]
1996
- Batmanghelich, S. , Weeks, I. and Woodhead, J. S. 1996. Detecting or quantifying multiple analytes using labelling techniques. EP 0478626 B1[Patent]
1992
- Batmanghelich, S. et al., 1992. Preparation of a chemiluminescent imidoester for the non-radioactive labelling of proteins. Journal of photochemistry and photobiology. B, Biology 12 (2), pp.193-201. (10.1016/1011-1344(92)85008-I)
1991
- Batmanghelich, S. et al., 1991. Synthesis and chemiluminescent evaluation of a series of phenyl N-alkylacridinium 9-carboxylates. Journal of Photochemistry and Photobiology A: Chemistry 56 (2-3), pp.249-254. (10.1016/1010-6030(91)80025-D)
1985
- Campbell, A. K. , Hallett, M. B. and Weeks, I. 1985. Chemiluminescence as an analytical tool in cell biology and medicine. In: Glick, D. ed. Methods of Biochemical Analysis. Vol. 31, New York: Wiley. , pp.317-416. (10.1002/9780470110522.ch7)
Articles
- Batmanghelich, S. et al., 1992. Preparation of a chemiluminescent imidoester for the non-radioactive labelling of proteins. Journal of photochemistry and photobiology. B, Biology 12 (2), pp.193-201. (10.1016/1011-1344(92)85008-I)
- Batmanghelich, S. et al., 1991. Synthesis and chemiluminescent evaluation of a series of phenyl N-alkylacridinium 9-carboxylates. Journal of Photochemistry and Photobiology A: Chemistry 56 (2-3), pp.249-254. (10.1016/1010-6030(91)80025-D)
- Brown, R. C. et al., 2009. Development and application of a novel acridinium ester for use as a chemiluminescent emitter in nucleic acid hybridisation assays using chemiluminescence quenching. Organic and Biomolecular Chemistry 7 (2), pp.386-394. (10.1039/b811947c)
- Browne, K. A. et al., 2012. Spectrally resolved chemiluminescent probes for sensitive multiplex molecular quantification. Analytical Chemistry 84 (21), pp.9222-9229. (10.1021/ac3017423)
- Browne, K. A. et al., 2011. Simultaneous quantification of multiple nucleic acid targets using chemiluminescent probes. Journal of the American Chemical Society 133 (37), pp.14637-14648. (10.1021/ja202221h)
- Bullock, N. et al. 2023. Perception of urinary biomarker tests among patients referred with suspected urological malignancy. BJUI Compass (10.1002/bco2.234)
- Cuff, S. et al. 2018. An improved cell-permeable fluorogenic substrate as the basis for a highly sensitive test for NAD(P)H quinone oxidoreductase 1 (NQO1) in living cells. Free Radical Biology and Medicine 116 , pp.141-148. (10.1016/j.freeradbiomed.2018.01.009)
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9 (1) 19694. (10.1038/s41598-019-55523-x)
- Moat, S. et al. 2017. Characterization of a blood spot creatine kinase skeletal muscle isoform immunoassay for high-throughput newborn screening of duchenne muscular dystrophy. Clinical Chemistry 63 (4), pp.908-914. (10.1373/clinchem.2016.268425)
- Moat, S. J. et al. 2021. Development of a high throughput SARS-CoV-2 antibody testing pathway using dried blood spot specimens. Annals of Clinical Biochemistry 58 (2)(10.1177/0004563220981106)
- Morris, C. et al. 2008. Comparison of transcription-mediated amplification and growth-based methods for the quantitation of Enterococcus bacteria in environmental waters. Applied and Environmental Microbiology 74 (10), pp.3319-3320. (10.1128/AEM.02623-07)
- Morris, C. et al. 2012. Utilising chemiluminescent methods for 'animal-free' toxicology tests [Abstract]. Toxicology Letters 211 (Supp.), pp.S104-S105. (10.1016/j.toxlet.2012.03.390)
- Morris, C. A. et al. 2017. Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicology in Vitro 39 , pp.15-28. (10.1016/j.tiv.2016.11.004)
- Smith, K. et al. 2000. Synthesis and properties of novel chemiluminescent biological probes: substituted 4-(2-succinimidyloxycarbonylethyl)phenyl 10-methylacridinium-9-carboxylate trifluoromethanesulphonate. Journal of Photochemistry and Photobiology A: Chemistry 132 (3), pp.181-191. (10.1016/S1010-6030(00)00209-4)
- Smith, K. et al. 2009. Synthesis and properties of novel chemiluminescent biological probes: 2- and 3-(2-Succinimidyloxycarbonylethyl)phenyl acridinium esters. Journal of Photochemistry and Photobiology A: Chemistry 203 (1), pp.72-79. (10.1016/j.jphotochem.2008.12.020)
- Walkley, N. et al. 2008. Investigation of transcription-mediated amplification as a rapid test method for Enterococci in recreational water. Journal of Environmental Monitoring 10 (9), pp.1064-1068. (10.1039/b810284h)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92 (1), pp.179-191. (10.1016/j.kint.2017.01.017)
Book sections
- Campbell, A. K. , Hallett, M. B. and Weeks, I. 1985. Chemiluminescence as an analytical tool in cell biology and medicine. In: Glick, D. ed. Methods of Biochemical Analysis. Vol. 31, New York: Wiley. , pp.317-416. (10.1002/9780470110522.ch7)
- Weeks, I. , Kricka, L. J. and Wild, D. 2013. Signal generation and detection systems (excluding homogeneous assays). In: Wild, D. ed. The Immunoassay Handbook. Elsevier. , pp.267-285. (10.1016/B978-0-08-097037-0.00018-X)
Patents
- Batmanghelich, S. , Weeks, I. and Woodhead, J. S. 1996. Detecting or quantifying multiple analytes using labelling techniques. EP 0478626 B1[Patent]
- Cheikh, A. B. et al., 1998. Labeled hybridization assay probes useful for the detection and quantification of multiple nucleic acid sequences. US5840873A[Patent]
Biography
Honours and awards
- 2009 - DSc Cardiff University
- 1980 - PhD Cardiff University
- 1976 - BSc Cardiff University
Professional memberships
- Fellow of the Royal College of Pathologists
- Fellow of the Royal Society of Medicine
- Fellow of the Royal Society of Chemistry
- Chartered Chemist
