Professor Nigel Williams
Professor, Division of Psychological Medicine and Clinical Neurosciences
Overview
My primary research interests focus on the molecular genetic analysis of common neuropsychiatric and neurological disorders, including schizophrenia, attention deficit hyperactivity disorder and Parkinson's disease.
Publication
2024
- Trastulla, L. et al. 2024. Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications 15, article number: 5534. (10.1038/s41467-024-49338-2)
- Tan, M. M. X. et al. 2024. Genome-wide determinants of mortality and motor progression in Parkinson’s disease. npj Parkinson's Disease 10(1), article number: 113. (10.1038/s41531-024-00729-8)
- Wu, L. Y. et al. 2024. Investigation of the genetic aetiology of Lewy body diseases with and without dementia. Brain Communications 6(4), article number: fcae190. (10.1093/braincomms/fcae190)
- Menon, P. J. et al. 2024. Genotype–phenotype correlation in PRKN- associated Parkinson’s disease. npj Parkinson's Disease 10, article number: 72. (10.1038/s41531-024-00677-3)
- Kim, J. J. et al. 2024. Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease. Nature Genetics 56(1), pp. 27-36. (10.1038/s41588-023-01584-8)
2023
- Martínez Carrasco, A. et al. 2023. Genome-wide analysis of motor progression in parkinson disease. Neurology Genetics 9(5), article number: e200092. (10.1212/NXG.0000000000200092)
- Hanna, S. J. et al. 2023. Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans. Frontiers in Immunology 14, article number: 1276255. (10.3389/fimmu.2023.1276255)
- Towns, C. et al. 2023. Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2). npj Parkinson's Disease 9(1), article number: 131. (10.1038/s41531-023-00533-w)
- Martinez-Carrasco, A. et al. 2023. Genetic meta-analysis of levodopa induced dyskinesia in Parkinson’s disease. npj Parkinson's Disease 9, article number: 128. (10.1038/s41531-023-00573-2)
- Millrine, D. et al. 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211(2), pp. 274-286. (10.4049/jimmunol.2300114)
- Lin, J. et al. 2023. Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia. Molecular Psychiatry 28, pp. 2071-2080. (10.1038/s41380-023-02009-y)
- Adams, R. L. et al. 2023. Psychopathology in adults with copy number variants. Psychological Medicine 53(7), pp. 3142-3149. (10.1017/S0033291721005201)
- Real, R. et al. 2023. Association between the LRP1B and APOE loci in the development of Parkinson’s disease dementia. Brain 146(5), pp. 1873-1887. (10.1093/brain/awac414)
- Chawner, S. J. R. A., Evans, A., IMAGINE-ID consortium, ., Williams, N., Owen, M. J., Hall, J. and van den Bree, M. B. M. 2023. Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions. Translational Psychiatry 13, article number: 7. (10.1038/s41398-022-02296-z)
- Winchester, L. et al. 2023. Identification of a possible proteomic biomarker in Parkinson’s disease: discovery and replication in blood, brain and cerebrospinal fluid. Brain Communications 5(1), article number: fcac343. (10.1093/braincomms/fcac343)
2022
- Harvey, J. et al. 2022. An epigenome wide association study of sub-phenotypes in Parkinson's disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 18(S4), article number: e069252. (10.1002/alz.069252)
- Sandor, C. et al. 2022. Universal clinical Parkinson’s disease axes identify a major influence of neuroinflammation. Genome Medicine 14, article number: 129. (10.1186/s13073-022-01132-9)
- Lawton, M. et al. 2022. Genetics of validated Parkinson’s disease subtypes in the Oxford Discovery and Tracking Parkinson’s cohorts. Journal of Neurology, Neurosurgery and Psychiatry 93(9), pp. 952-959. (10.1136/jnnp-2021-327376)
- Lobanov, S. et al. 2022. Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1. npj Genomic Medicine 7, article number: 53. (10.1038/s41525-022-00317-w)
- Vijiaratnam, N. et al. 2022. Combining biomarkers for prognostic modelling of Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, article number: jnnp-2021-328365. (10.1136/jnnp-2021-328365)
- McAllister, B. et al. 2022. Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset. Nature Neuroscience 25, pp. 446-457. (10.1038/s41593-022-01033-5)
- Trubetskoy, V. et al. 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604, pp. 502-508. (10.1038/s41586-022-04434-5)
2021
- Cleynen, I. et al. 2021. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. Molecular Psychiatry, pp. 4496-4510. (10.1038/s41380-020-0654-3)
- Hrastelj, J. et al. 2021. CSF-resident CD4+ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis. Brain Communications (10.1093/braincomms/fcab155)
- Owen, M. J. and Williams, N. M. 2021. Explaining the missing heritability of psychiatric disorders. World Psychiatry 20(2), pp. 294-295. (10.1002/wps.20870)
- Kia, D. A. et al. 2021. Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets. JAMA Neurology 78(4), pp. 464-472. (10.1001/jamaneurol.2020.5257)
- Chen, Z. et al. 2021. Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage. Nature Communications 12(1), article number: 2076. (10.1038/s41467-021-22262-5)
- McAllister, B. et al. 2021. Timing and impact of psychiatric, cognitive, and motor abnormalities in Huntington disease. Neurology 96(19), pp. e2395-e2406. (10.1212/WNL.0000000000011893)
- Tan, M. M. et al. 2021. Genome-wide association studies of cognitive and motor progression in Parkinson's disease. Movement Disorders 36(2), pp. 424-433. (10.1002/mds.28342)
- Linden, S. C. et al. 2021. The psychiatric phenotypes of 1q21 distal deletion and duplication. Translational Psychiatry 11, article number: 105. (10.1038/s41398-021-01226-9)
- Choompoo, N. et al. 2021. Induced pluripotent stem cells derived from the developing striatum as a potential donor source for cell replacement therapy for Huntington disease. Cytotherapy 23(2), pp. 111-118. (10.1016/j.jcyt.2020.06.001)
- Lubbe, S. J. et al. 2021. Assessing the relationship between monoallelic PRKN mutations and Parkinson’s risk. Human Molecular Genetics 30(1), pp. 78-86. (10.1093/hmg/ddaa273)
2020
- Davies, R. et al. 2020. Using common genetic variation to examine phenotypic expression and risk prediction in 22q11.2 Deletion Syndrome. Nature Medicine 26, pp. 1912-1918. (10.1038/s41591-020-1103-1)
- Dima, D. C. et al. 2020. Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk. Translational Psychiatry 10, article number: 324. (10.1038/s41398-020-00998-w)
- Williams, N. M. et al. 2020. Genome‐wide association study of pain in Parkinson's disease implicates TRPM8 as a risk factor. Movement Disorders 35(4), pp. 705-707. (10.1002/mds.28001)
- Jabbari, E. et al. 2020. Diagnosis across the spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome. JAMA Neurology 77(3), pp. 377-387. (10.1001/jamaneurol.2019.4347)
- McAllister, B. et al. 2020. The onset and prevalence of motor and psychiatric symptoms in Huntington’s disease. [Online]. bioRxiv. (10.1101/2020.05.26.116798)
2019
- Tan, M. M. et al. 2019. Genetic analysis of Mendelian mutations in a large UK population-based Parkinson's disease study. Brain 142(9), pp. 2828-2844. (10.1093/brain/awz191)
- Jabbari, E. et al. 2019. The genetic and clinico-pathological profile of early-onset progressive supranuclear palsy. Movement Disorders 34(9), pp. 1307-1314. (10.1002/mds.27786)
- Malek, N. et al. 2019. L-dopa responsiveness in early Parkinson's disease is associated with the rate of motor progression. Parkinsonism and Related Disorders 65, pp. 55-61. (10.1016/j.parkreldis.2019.05.022)
- Jones, H. J., Hubbard, L., Mitchell, R. E., Jones, S. A., Williams, N. M., Zammit, S. and Hall, J. 2019. Association of genetic risk for rheumatoid arthritis with cognitive and psychiatric phenotypes across childhood and adolescence. JAMA Network Open 2(6), pp. -., article number: e196118. (10.1001/jamanetworkopen.2019.6118)
- Twohig, J. P. et al. 2019. Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. Nature Immunology 20, pp. 458-470. (10.1038/s41590-019-0350-0)
- Drakesmith, M. et al. 2019. Genetic risk for schizophrenia and developmental delay is associated with shape and microstructure of midline white-matter structures. Translational Psychiatry 9(1), article number: 102. (10.1038/s41398-019-0440-7)
2018
- Lawton, M. et al. 2018. Developing and validating Parkinson's disease subtypes and their motor and cognitive progression. Journal of Neurology, Neurosurgery and Psychiatry 89(12), pp. 1279-1287. (10.1136/jnnp-2018-318337)
- Silverdale, M. A. et al. 2018. A detailed clinical study of pain in 1957 participants with early/moderate Parkinson's disease. Parkinsonism & Related Disorders 56, pp. 27-32. (10.1016/j.parkreldis.2018.06.001)
- Bakhsh, A. D. et al. 2018. An InDel in Phospholipase-C-B-1 is linked with euthyroid multinodular goiter. Thyroid 28(7), pp. 891-901. (10.1089/thy.2017.0312)
- Anttila, V. et al. 2018. Analysis of shared heritability in common disorders of the brain. Science 360(6395), article number: eaap8757. (10.1126/science.aap8757)
- Malek, N. et al. 2018. Features of GBA-associated Parkinson's disease at presentation in the UK Tracking Parkinson's study. Journal of Neurology, Neurosurgery and Psychiatry 89(7), pp. 702-709. (10.1136/jnnp-2017-317348)
- Ruderfer, D. M. et al. 2018. Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes. Cell 173(7), pp. 1705-1715.e16. (10.1016/j.cell.2018.05.046)
- Boot, E. et al. 2018. Typical features of Parkinson disease and diagnostic challenges with microdeletion 22q11.2. Neurology 90(23), pp. e2059-e2067. (10.1212/WNL.0000000000005660)
2017
- Jansen, I. E. et al. 2017. Establishing the role of rare coding variants in known Parkinson's disease risk loci. Neurobiology of Aging 59, pp. 220.e11-220.e18. (10.1016/j.neurobiolaging.2017.07.009)
- Greene, C. et al. 2017. Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia. Molecular Psychiatry 23, pp. 2156-2166. (10.1038/mp.2017.156)
- Malek, N. et al. 2017. Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases. Parkinsonism & Related Disorders 40, pp. 40-46. (10.1016/j.parkreldis.2017.04.006)
- Marshall, C. R. et al. 2017. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics 49, pp. 27-35. (10.1038/ng.3725)
2016
- Lubbe, S. J. et al. 2016. Additional rare variant analysis in Parkinson?s disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance. Human Molecular Genetics 25(24), pp. 5483-5489. (10.1093/hmg/ddw348)
- Lawton, M. et al. 2016. Equating scores of the University of Pennsylvania smell identification test and sniffin' sticks test in patients with Parkinson's disease. Parkinsonism & Related Disorders 33, pp. 96-101. (10.1016/j.parkreldis.2016.09.023)
- Malek, N. et al. 2016. Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease. Movement Disorders 31(10), pp. 1518-1526. (10.1002/mds.26698)
- Malek, N. et al. 2016. Olfaction in Parkin single and compound heterozygotes in a cohort of young onset Parkinson's disease patients. Acta Neurologica Scandinavica 134(4), pp. 271-276. (10.1111/ane.12538)
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Swallow, D. M. A. et al. 2016. Statins are underused in recent-onset Parkinson's disease with increased vascular risk: findings from the UK Tracking Parkinson's and Oxford Parkinson's Disease Centre (OPDC) discovery cohorts. Journal of Neurology, Neurosurgery & Psychiatry 87(11), pp. 1183-1190. (10.1136/jnnp-2016-313642)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Mok, K. Y. et al. 2016. Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data. Lancet Neurology 15(6), pp. 585-596. (10.1016/S1474-4422(16)00071-5)
- Swallow, D. M. et al. 2016. Variation in recent onset Parkinson's disease: implications for prodromal detection. Journal of Parkinson's Disease 6(2), pp. 289-300. (10.3233/JPD-150741)
- Franke, B. et al. 2016. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience 19(3), pp. 420-431. (10.1038/nn.4228)
- Lubbe, S. J. et al. 2016. Is the MC1R variant p.R160W associated with Parkinson's?. Annals of Neurology 79(1), pp. 159-161. (10.1002/ana.24527)
2015
- Nalls, M. A. et al. 2015. Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study. The Lancet Neurology 14(10), pp. 1002-1009. (10.1016/S1474-4422(15)00178-7)
- Nalls, M. A., Escott-Price, V., Williams, N. M., Lubbe, S., Keller, M. F., Morris, H. R. and Singleton, A. B. 2015. Genetic risk and age in Parkinson's disease: Continuum not stratum. Movement Disorders 30(6), pp. 850-854. (10.1002/mds.26192)
- Escott-Price, V. et al. 2015. Polygenic risk of Parkinson disease is correlated with disease age at onset. Annals of Neurology 77(4), pp. 582-591. (10.1002/ana.24335)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
- Malek, N. et al. 2015. Tracking Parkinson's: study design and baseline patient data. Journal of Parkinson's Disease 5(4), pp. 947-959. (10.3233/JPD-150662)
2014
- Gusev, A. et al. 2014. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. American Journal of Human Genetics 95(5), pp. 535-552. (10.1016/j.ajhg.2014.10.004)
- Nalls, M. A. et al. 2014. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics 46(9), pp. 989-993. (10.1038/ng.3043)
- Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53(7), pp. 761-770.e26. (10.1016/j.jaac.2014.03.004)
- Ripke, S. et al. 2014. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511(7510), pp. 421-427. (10.1038/nature13595)
- Craddock, N. J. et al. 2014. Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophrenia Bulletin 40(4), pp. 729-736. (10.1093/schbul/sbu069)
- Dong, J. et al. 2014. Susceptibility loci for pigmentation and melanoma in relation to Parkinson's disease. Neurobiology of Aging 35(6), pp. 1512.e5-10. (10.1016/j.neurobiolaging.2013.12.020)
- Hart, A. B. et al. 2014. Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder. Proceedings of the National Academy of Sciences 111(16), pp. 5968-5973. (10.1073/pnas.1318810111)
- Monks, S. et al. 2014. Further evidence for high rates of schizophrenia in 22q11.2 deletion syndrome. Schizophrenia Research 153(1-3), pp. 231-236. (10.1016/j.schres.2014.01.020)
- Beilina, A. et al. 2014. Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America 111(7), pp. 2626-2631. (10.1073/pnas.1318306111)
2013
- van Scheltinga, A. F. T. et al. 2013. Schizophrenia genetic variants are not associated with intelligence. Psychological Medicine 43(12), pp. 2563-2570. (10.1017/S0033291713000196)
- Nalls, M. A. et al. 2013. Genetic comorbidities in Parkinson's disease. Human Molecular Genetics 23(3), pp. 831-41. (10.1093/hmg/ddt465)
- Lee, S. et al. 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics 45(9), pp. 984-994. (10.1038/ng.2711)
- Ripke, S. et al. 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics 45(10), pp. 1150-1159. (10.1038/ng.2742)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
- Yang, L. et al. 2013. Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: Genome-wide association study of both common and rare variants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162(5), pp. 419-430. (10.1002/ajmg.b.32169)
- Klebe, S. et al. 2013. The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism. Journal of Neurology, Neurosurgery & Psychiatry 84(6), pp. 666-673. (10.1136/jnnp-2012-304475)
- Terwisscha van Scheltinga, A. F. et al. 2013. Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biological Psychiatry 73(6), pp. 525-531. (10.1016/j.biopsych.2012.08.017)
- Holmans, P. A. et al. 2013. A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease. Human Molecular Genetics 22(5), pp. 1039-1049. (10.1093/hmg/dds492)
- Escott-Price, V. et al. 2013. Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk. JAMA Neurology 70(10), pp. 1268-1276. (10.1001/jamaneurol.2013.448)
2012
- Keller, M. F. et al. 2012. Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Human Molecular Genetics 21(22), pp. 4996-5009. (10.1093/hmg/dds335)
- Kilarski, L. et al. 2012. Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1)andLRRK2in early-onset Parkinson's disease. Movement Disorders 27(12), pp. 1522-1529. (10.1002/mds.25132)
- Levinson, D. F. et al. 2012. Genome-wide association study of multiplex schizophrenia pedigrees. American Journal of Psychiatry 169(9), pp. 963-973. (10.1176/appi.ajp.2012.11091423)
- Mittag, F. et al. 2012. Use of support vector machines for disease risk prediction in genome-wide association studies: Concerns and opportunities. Human Mutation 33(12), pp. 1708-1718. (10.1002/humu.22161)
- Jia, P. et al. 2012. Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Computational Biology 8(7), article number: e1002587. (10.1371/journal.pcbi.1002587)
- O'Dowd, S. et al. 2012. C9ORF72 expansion in amyotrophic lateral sclerosis/frontotemporal dementia also causes parkinsonism. Movement Disorders 27(8), pp. 1072-1074. (10.1002/mds.25022)
- Majounie, E. et al. 2012. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. The Lancet Neurology 11(4), pp. 323-330. (10.1016/S1474-4422(12)70043-1)
- Simón-Sánchez, J. et al. 2012. Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's Disease. PLoS ONE 7(3), article number: e28787. (10.1371/journal.pone.0028787)
- Jia, P. et al. 2012. A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia. Journal of Medical Genetics 49(2), pp. 96-103. (10.1136/jmedgenet-2011-100397)
- Stergiakouli, E. et al. 2012. Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD. American Journal of Psychiatry 169(2), pp. 186-194. (10.1176/appi.ajp.2011.11040551)
- Williams, N. M. et al. 2012. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. American Journal of Psychiatry 169(2), pp. 195-204. (10.1176/appi.ajp.2011.11060822)
- Elia, J. et al. 2012. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nature Genetics 44(1), pp. 78-84. (10.1038/ng.1013)
- Mok, K. et al. 2012. The chromosome 9 ALS and FTD locus is probably derived from a single founder. Neurobiology of Aging 33(1), pp. 209.e3-209.e8. (10.1016/j.neurobiolaging.2011.08.005)
- Charlesworth, G. et al. 2012. Tau acts as an independent genetic risk factor in pathologically proven PD. Neurobiology of Aging 33(4), pp. 838.e7-838.e11. (10.1016/j.neurobiolaging.2011.11.001)
- Morris, H. R., Waite, A. J., Williams, N. M., Neal, J. W. and Blake, D. J. 2012. Recent advances in the genetics of the ALS-FTLD complex. Current Neurology and Neuroscience Reports 12(3), pp. 243-250. (10.1007/s11910-012-0268-5)
2011
- Hinney, A. et al. 2011. Genome-wide association study in German patients with attention deficit/hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 888-897. (10.1002/ajmg.b.31246)
- Cardno, A. G. et al. 2011. A genomewide linkage study of age at onset in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B(8), pp. 929-940. (10.1002/ajmg.1404)
- Renton, A. et al. 2011. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 72(2), pp. 257-268. (10.1016/j.neuron.2011.09.010)
- Ripke, S. et al. 2011. Genome-wide association study identifies five new schizophrenia loci [Letter]. Nature Genetics 43(10), pp. 969-976. (10.1038/ng.940)
- Williams, N. M. 2011. Molecular mechanisms in 22q11 deletion syndrome. Schizophrenia Bulletin 37(5), pp. 882-889. (10.1093/schbul/sbr095)
- Chen, J. et al. 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131(1-3), pp. 43-51.
- Chen, J. et al. 2011. Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia. Schizophrenia Research 131(1-3), pp. 43-51. (10.1016/j.schres.2011.06.023)
- Williams, H. J. et al. 2011. Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Molecular Psychiatry 16(4), pp. 429-441. (10.1038/mp.2010.36)
- Stergiakouli, E. et al. 2011. Steroid sulfatase is a potential modifier of cognition in attention deficit hyperactivity disorder. Genes Brain and Behavior 10(3), pp. 334-344. (10.1111/j.1601-183x.2010.00672.x)
- Pearson, J. P. et al. 2011. Familial frontotemporal dementia with amyotrophic lateral sclerosis and a shared haplotype on chromosome 9p. Journal of Neurology 258(4), pp. 647-655. (10.1007/s00415-010-5815-x)
- O'Dushlaine, C. et al. 2011. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Molecular Psychiatry 16(3), pp. 286-292. (10.1038/mp.2010.7)
- Nalls, M. A. et al. 2011. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. The Lancet 377(9766), pp. 641-649. (10.1016/S0140-6736(10)62345-8)
- Morris, H. R., Pearson, J. P., Williams, N. M., Wickremaratchi, M., International Parkinson's Disease Genomics Consortium (IPDGC), . and Wellcome Trust Case Control Consortium (WTCCC), . 2011. A two-stage meta-analysis identifies several new loci for Parkinson's Disease. PLoS Genetics 7(6), article number: e1002142. (10.1371/journal.pgen.1002142)
- Bridges, M. et al. 2011. Genetic classification of populations using supervised learning. PLoS ONE 6(5), article number: e14802. (10.1371/journal.pone.0014802)
- Williams, N. M., O'Donovan, M. C., Owen, M. J. and Thapar, A. 2011. Structural variations in attention-deficit hyperactivity disorder - Authors' reply [Letter]. The Lancet 377(9763), pp. 378. (10.1016/S0140-6736(11)60121-9)
- Hamshere, M. L. et al. 2011. Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156(8), pp. 929-940. (10.1002/ajmg.b.31240)
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
2010
- Carroll, L. S. et al. 2010. Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha. Molecular Psychiatry 15(11), pp. 1101-1111. (10.1038/mp.2009.96)
- Williams, N. M. et al. 2010. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. The Lancet 376(9750), pp. 1401-1408. (10.1016/S0140-6736(10)61109-9)
- Pearson, J. P. et al. 2010. Prevalence of mutations in Parkin, PINK1, and DJ-1 in early onset Parkinson's Disease - a community based and regional study [Conference Abstract]. Movement Disorders 25(3), pp. S610-S610.
- Allison, D. B. et al. 2010. Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function. PLoS Genetics 6(9), article number: e1001097. (10.1371/journal.pgen.1001097)
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2009
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2008
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2007
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2005
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2004
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2003
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2002
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2001
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2000
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1999
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1998
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1997
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1996
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1995
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1994
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- Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2002. Genome scans and microarrays: converging on genes for schizophrenia?. Genome Biology 3(4), pp. Reviews1011-Reviews1011.5.
- Bennett, P. et al. 2002. The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report. Molecular Psychiatry 7(2), pp. 189-200. (10.1038/sj.mp.4000957)
- Sklar, P. et al. 2001. Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nature Genetics 28(2), pp. 126-128. (10.1038/88836)
- Bowen, T. et al. 2001. Mutation screening of the KCNN3 gene reveals a rare frameshift mutation [Letter]. Molecular Psychiatry 6(3), pp. 259-260. (10.1038/sj.mp.4000128)
- McEntagart, M. et al. 2001. Localization of the gene for distal hereditary motor neuronopathy VII (dHMN-VII) to chromosome 2q14. American Journal of Human Genetics 68(5), pp. 1270-1276. (10.1086/320122)
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Levinson, D. F. et al. 2000. Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III. American Journal of Human Genetics 67(3), pp. 652-663. (10.1086/303041)
- Murphy, K. C. et al. 2000. Chromosome 22q, velo-cardio-facial syndrome (VCFS) and schizophrenia. Journal of Medical Genetics 37, pp. S58-S58.
- Walters, S. E., Williams, N. M., Spurlock, G., Sanders, R. D., McCarthy, G. M., Cardno, A. G. and Owen, M. J. 2000. Identification of a polymorphism in the human NURR1 gene and investigation of an association with schizophrenia. American Journal of Medical Genetics 96(4), pp. 535-535.
- Bray, N. J. et al. 2000. No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia. Psychiatric Genetics 10(2), pp. 83-86. (10.1097/00041444-200010020-00005)
- Morris, D. W. et al. 2000. Family-based association mapping provides evidence for a gene for reading disability on chromosome 15q. Human Molecular Genetics 9(5), pp. 843-848. (10.1093/hmg/9.5.843)
- Austin, J. et al. 2000. Association analysis of the proneurotensin gene and bipolar disorder. Psychiatric Genetics 10(1), pp. 51-54. (10.1097/00041444-200010010-00009)
- Austin, J. et al. 2000. Comparative sequencing of the proneurotensin gene and association studies in schizophrenia. Molecular Psychiatry 5(2), pp. 208-212. (10.1038/sj.mp.4000693)
- Kirov, G., Stephens, M., Williams, N. M., O'Donovan, M. C. and Owen, M. J. 2000. Automated genotyping of single-nucleotide polymorphisms by extension of fluorescently labelled primers: analysis of individual and pooled DNA samples. Balkan Journal of Medical Genetics 3, pp. 23-28.
- Kirov, G., Williams, N. M., Sham, P., Craddock, N. J. and Owen, M. J. 2000. Pooled genotyping of microsatellite markers in parent-offspring trios. Genome Research 10(1), pp. 105-115.
- Hoogendoorn, B. et al. 2000. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Human Genetics 107(5), pp. 488-493. (10.1007/s004390000397)
- Williams, N. M. et al. 1999. A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs. Human Molecular Genetics 8(9), pp. 1729-1739. (10.1093/hmg/8.9.1729)
- Norton, N. et al. 1999. No evidence for association between schizophrenia and MAO-A promoter polymorphism. Molecular Psychiatry 4, pp. S96-S96.
- Williams, N. M., Bowen, T., Kirov, G., Williams, H., Hoogendorn, B., Asherson, P. and Owen, M. J. 1999. Polymorphism screening and association studies of the Wolfram syndrome gene in schizophrenia. Molecular Psychiatry 4(supp1), pp. S42-S42.
- Rees, M. I. et al. 1999. Autosome search for schizophrenia susceptibility genes in multiply affected families. Molecular Psychiatry 4(4), pp. 353-359. (10.1038/sj.mp.4000521)
- Cardno, A. G. et al. 1999. CAG repeat length in the hKCa3 gene and symptom dimensions in schizophrenia. Biological Psychiatry 45(12), pp. 1592-1596. (10.1016/s0006-3223(99)00033-5)
- Fisher, P. J. et al. 1999. DNA pooling identifies QTLs on chromosome 4 for general cognitive ability in children. Human Molecular Genetics 8(5), pp. 915-922. (10.1093/hmg/8.5.915)
- Guy, C. et al. 1999. No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder. American Journal of Medical Genetics 88(1), pp. 57-60. (10.1002/(sici)1096-8628(19990205)88:1%3C57::aid-ajmg10%3E3.0.co;2-6)
- Kehoe, P. et al. 1999. A full genome scan for late onset Alzheimer's disease. Human Molecular Genetics 8(2), pp. 237-245. (10.1093/hmg/8.2.237)
- Kehoe, P. G. et al. 1999. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nature Genetics 21(1), pp. 71-72. (10.1038/5009)
- Hoogendoorn, B., Owen, M. J., Oefner, P. J., Williams, N. M., Austin, J. and O'Donovan, M. C. 1999. Genotyping single nucleotide polymorphisms by primer extension and high performance liquid chromatography. Human Genetics 104(1), pp. 89-93. (10.1007/s004390050915)
- Spurlock, G., Williams, N. M., Williams, H. and Owen, M. J. 1998. Polymorphism screening of the human type 1 sigma (sigma) receptor (a candidate gene for schizophrenia) using a modified dideoxy fingerprinting technique.. American Journal of Medical Genetics 81(6), pp. 525-526.
- Williams, N. M., Fenton, I. and Owen, M. J. 1998. PsycheMap - An interactive Internet-based database of psychiatric genetics linkage, association, and genome mapping projects. American Journal of Medical Genetics 81(6), pp. 463-464.
- Fisher, P. J. et al. 1998. DNA pooling for genomic scanning - Application to an association study. American Journal of Medical Genetics 81(6), pp. 469-469.
- Williams, N. M., Kirov, G., Craddock, N. J. and Owen, M. J. 1998. Screening the critical region on chromosome 4p with DNA pooling for association with bipolar disorder. American Journal of Medical Genetics 81(6), pp. 486-486.
- Hill, L. et al. 1998. QTLs for general cognitive ability in children: DNA pooling for chromosome 22. American Journal of Medical Genetics 81(6), pp. 486-486.
- Wu, W. S. et al. 1998. Genetic studies on chromosome 12 in late-onset Alzheimer disease. JAMA - The Journal of the American Medical Association 280(7), pp. 619-622. (10.1001/jama.280.7.619)
- Asherson, P. et al. 1998. A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder. Molecular Psychiatry 3(4), pp. 310-320. (10.1038/sj.mp.4000399)
- Daniels, J., Holmans, P. A., Williams, N. M., Turic, D., McGuffin, P., Plomin, R. and Owen, M. J. 1998. A simple method for analyzing microsatellite allele image patterns generated from DNA pools and its application to allelic association studies. American Journal of Human Genetics 62(5), pp. 1189-1197. (10.1086/301816)
- Bowen, T. et al. 1998. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Molecular Psychiatry 3(3), pp. 266-269. (10.1038/sj.mp.4000400)
- Murphy, K. C., Williams, N. M., Cardno, A. G., Jones, L. A., Holmans, P. A., McGuffin, P. and Owen, M. J. 1998. A linkage study of chromosome 22q in SIB-pairs with schizophrenia. Schizophrenia Research 29(1-2), pp. 131-132. (10.1016/S0920-9964(97)88632-X)
- Baboolal, K., Ravine, D., Daniels, J., Williams, N. M., Holmans, P. A., Coles, G. A. and Williams, J. D. 1997. Association of the angiotensin I converting enzyme gene deletion polymorphism with early onset of ESRF in PKD1 adult polycystic kidney disease. Kidney International 52(3), pp. 607-613. (10.1038/ki.1997.373)
- Williams, N. M., Cardno, A. G., Murphy, K. C., Jones, L. A., Asherson, P., McGuffin, P. and Owen, M. J. 1997. Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene. Psychiatric Genetics 7(2), pp. 83-85. (10.1097/00041444-199722000-00005)
- Daniels, J. K. et al. 1997. Linkage study of chromosome 6p in sib-pairs with schizophrenia. American Journal of Medical Genetics 74(3), pp. 319-323. (10.1002/(SICI)1096-8628(19970531)74:3<319::AID-AJMG14>3.0.CO;2-R)
- Williams, N. M. et al. 1997. No evidence for an allelic association between schizophrenia and markers D22S278 and D22S283. American Journal of Medical Genetics 74(1), pp. 37-39. (10.1002/(SICI)1096-8628(19970221)74:1<37::AID-AJMG8>3.0.CO;2-S)
- Thomas, N. S. T. et al. 1997. Molecular genetic studies in familial Rett syndrome. European Child & Adolescent Psychiatry 6(Supp 1), pp. 94-94.
- Craddock, N. J., Daniels, J., Holmans, P. A., Williams, N. M. and Owen, M. J. 1996. Increasing the efficiency of genomic searches for linkage in complex disorders by DNA pooling of affected sib-pairs. Molecular Psychiatry 1(1), pp. 59-64.
- Daniels, J. K. et al. 1996. No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity. American Journal of Psychiatry 153(2), pp. 268-270. (10.1176/ajp.153.2.268)
- Lin, M. W. et al. 1996. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. Cytogenetics and Cell Genetics 75, pp. 2-3.
- Lin, M. W. et al. 1995. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. Psychiatric Genetics 5(3), pp. 117-126. (10.1097/00041444-199505030-00004)
- Craddock, N. J., Roberts, Q., Williams, N. M., McGuffin, P. and Owen, M. . J. 1995. Association study of bipolar disorder using a functional polymorphism (Ser311-->Cys) in the dopamine D2 receptor gene. Psychiatric Genetics 5(2), pp. 63-65.
- Asherson, P., Williams, N. M., Roberts, E., McGuffin, M. and Owen, M. J. 1994. DRD2 Ser311/Cys311 polymorphism in schizophrenia. The Lancet 343(8904), pp. 1045-1045.
Websites
- McAllister, B. et al. 2020. The onset and prevalence of motor and psychiatric symptoms in Huntington’s disease. [Online]. bioRxiv. (10.1101/2020.05.26.116798)
Research
- Functional Pathway and Gene Ontology Analysis of Whole Genome Data in Parkinson's Disease. - Parkinson's Disease Society (2009) (N Williams, H Morris, V Moskvina, P Holmans)
- Follow up of Genome-wide association studies of large cohorts of Parkinson's disease – Parkinson's Disease Society (Ref:J-0804) (2008) (N Wood, R Barker, D Burn, P Chinnery, J Hardy, H Morris, K Morrison, C Clarke, N Williams)
- A UK Genome-Wide Association Study in Parkinson's disease. Wellcome Trust Application for a Genome-Wide Association Study (2008) (N Wood, R Barker, D Burn, P Chinnery, J Hardy, H Morris, K Morrison, C Clarke, N Williams)
- Detecting chromosomal anomalies in children with Attention Deficit Hyperactivity Disorder and learning disability/mental retardation using microarray based comparative genomic hybridisation. Action Medical Research Project Grant (A Thapar, N Williams, M Owen, M O'Donovan).
- Genomic and functional analysis of dysbindin in the genesis of schizophrenia. Wellcome Trust Project Grant. GR077693MF (N Williams, MC O'Donovan, MJ Owen)
- Molecular Genetic Studies of Schizophrenia. MRC Programme Grant Renewal. G9309834 (MJ Owen, P Holmans, G Kirov, NM Williams, MC O'Donovan)
- The Genetic Basis of Neuropsychiatric Disorders. MRC Co-operative Group Renewal. G9810900 (M Owen, MC O'Donovan, N Craddock, J Williams, A Thapar, P Buckland, L Jones, N Williams, S Dunnett, A Rosser, G Kirov)
- Susceptibility genes for psychosis in individuals with velo-cardio-facial syndrome (VCFS) Wellcome Trust Project Grant. GR067869 (M O'Donovan, M Owen, D Murphy, N Williams, K Murphy)
Contact Details
WilliamsNM@cardiff.ac.uk
+44 29206 88466
Hadyn Ellis Building, Room 2.50, Maindy Road, Cardiff, CF24 4HQ
+44 29206 88466
Hadyn Ellis Building, Room 2.50, Maindy Road, Cardiff, CF24 4HQ