Professor Thomas Wirth
Professor of Organic Chemistry
- Available for postgraduate supervision
Overview
Research interests
Synthetic Methodology:
- Hypervalent Iodine Reagents
- Chiral Selenium Reagents
- Electrochemical Methods
supported by Computational Chemistry
Microreactor Technology:
- Dangerous Reactions
- Unusual Reaction Conditions
- Electrochemical Synthesis
Links
Personal Web Site: Wirth Group Web Site
Publication
2024
- Patra, T., Arepally, S., Seitz, J. and Wirth, T. 2024. Electrocatalytic continuous flow chlorinations with iodine(I/III) mediators. Nature Communications 15(1), article number: 6329. (10.1038/s41467-024-50643-z)
- Pramanik, M., Das, S., Babaahmadi, R., Pahar, S., Wirth, T., Richards, E. and Melen, R. L. 2024. B(C6F5)3-catalyzed selective C-H chalcogenation of arenes and heteroarenes. Chem (10.1016/j.chempr.2024.05.025)
- Singh, F. and Wirth, T. 2024. Selected Diastereoselective Reactions: Hypervalent iodine chemistry. In: Cossy, J. ed. Comprehensive Chirality Volume 1: Chiral Pool and Diastereoselective Synthesis. Elsevier
- Edwards, L., Kariuki, B. M., Didsbury, M., Jones, C. D. and Wirth, T. 2024. Deville rebooted – practical N 2 O 5 synthesis †. Chemical Communications 60(46), pp. 5920-5923. (10.1039/d4cc01403k)
- Alzaidi, O. and Wirth, T. 2024. Continuous flow electroselenocyclization of allylamides and Unsaturated Oximes to selenofunctionalized oxazolines and isoxazolines. ACS Organic & Inorganic Au 4(3), pp. 350-355. (10.1021/acsorginorgau.4c00008)
- Pahar, S., van Ingen, Y., Babaahmadi, R., Kariuki, B. M., Wirth, T., Richards, E. and Melen, R. L. 2024. Diverse reactivity of amidinate-supported boron centers with the hypersilyl anion and access to a monomeric secondary boron hydride. Inorganic Chemistry 63(18), pp. 8302–8311. (10.1021/acs.inorgchem.4c00612)
- Ali, R., Wolfe, C. S. and Wirth, T. 2024. Non‐conventional methodologies for the synthesis of N‐Nntrosamines. Chemistry ‐ Methods 4(4), article number: e202300053. (10.1002/cmtd.202300053)
- Mizar, P., Arepally, S. and Wirth, T. 2024. Biphasic organic synthesis with continuous electro-flow. Current Opinion in Green and Sustainable Chemistry 46, article number: 100896. (10.1016/j.cogsc.2024.100896)
- Rahman, M. T. and Wirth, T. 2024. Sicherer Umgang mit gefährlichen Chemikalien im Durchfluss. In: Sharma, U. K. and Van der Eycken, E. V. eds. Flow-Chemie für die Synthese von Heterocyclen. Cham: Springer, pp. 375–408., (10.1007/978-3-031-51912-3_8)
- Alotaibi, N. et al. 2024. B(C6F5)3-catalysed alkylation of imidazo[1,2-a]pyridines using α,β-unsaturated ketones. European Journal of Organic Chemistry 27(12), article number: e202400022. (10.1002/ejoc.202400022)
- Guerzoni, M. G., van Ingen, Y., Babaahmadi, R., Wirth, T., Richards, E. and Melen, R. L. 2024. An un-forgotten classic: the nitro-Mannich reaction between nitrones and silyl nitronates catalysed by B(C6F5)3 †. Chemical Science 15(7) (10.1039/d3sc05672d)
2023
- Khan, M. N., van Ingen, Y., Boruah, T., McLauchlan, A., Wirth, T. and Melen, R. L. 2023. Advances in CO2 activation by frustrated Lewis pairs: from stoichiometric to catalytic reactions. Chemical Science 14(47), pp. 13661-13695. (10.1039/d3sc03907b)
- Ali, R., Patra, T. and Wirth, T. 2023. Alkene reactions with superoxide radical anions in flow electrochemistry. Faraday Discussions 247, pp. 297-301. (10.1039/D3FD00050H)
- Avanthay, M. et al. 2023. New strategies in organic electrosynthesis: General discussion. Faraday Discussions 247, pp. 125-131. (10.1039/D3FD90039H)
- Alkayal, A. et al. 2023. Flow cells and reactor design: General discussion. Faraday Discussions 247, pp. 333-341. (10.1039/D3FD90042H)
- Gutiérrez López, M. ?., Ali, R., Tan, M., Sakai, N., Wirth, T. and Matile, S. 2023. Electric field–assisted anion-π catalysis on carbon nanotubes in electrochemical microfluidic devices. Science Advances 9(41), article number: eadj5502. (10.1126/sciadv.adj5502)
- Boruah, T., Melen, R. L. and Wirth, T. 2023. Isodesmic metathesis chemistry: A novel way to recycle P(V). Chem Catalysis 3(8), article number: 100731. (10.1016/j.checat.2023.100731)
- Winterson, B., Bhattacherjee, D. and Wirth, T. 2023. Hypervalent halogen compounds in electrochemical reactions: advantages and prospects. Advanced Synthesis & Catalysis 365(16), pp. 2676-2689. (10.1002/adsc.202300412)
- Alkahtani, R. and Wirth, T. 2023. Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones. ACS Organic & Inorganic Au 3(4), pp. 209-216. (10.1021/acsorginorgau.3c00012)
- Ali, R., Babaahmadi, R., Didsbury, M., Stephens, R., Melen, R. L. and Wirth, T. 2023. Flow electrochemistry for the N‐Nitrosation of secondary amines. Chemistry - A European Journal 29(32), article number: e202300957. (10.1002/chem.202300957)
- Wirth, T. 2023. Hypervalent iodine in electrochemical reactions: advantages and prospects. SIS Letters(24)
- Alotaibi, N. et al. 2023. B(3,4,5-F3H2C6)3 Lewis acid-catalysed C3-allylation of indoles. Dalton Transactions 52(16) (10.1039/d3dt00745f)
- Spils, J., Wirth, T. and Nachtsheim, B. J. 2023. Two-step continuous-flow synthesis of 6-membered cyclic iodonium salts via anodic oxidation. Beilstein Journal of Organic Chemistry 19, pp. 27-32. (10.3762/bjoc.19.2)
2022
- Patra, T. and Wirth, T. 2022. Oxidative cleavage of alkenes by photosensitized nitroarenes. Angewandte Chemie International Edition 61(47), article number: e202213772. (10.1002/anie.202213772)
- Singh, F. V., Shetgaonkar, S. E., Krishnan, M. and Wirth, T. 2022. Progress in organocatalysis with hypervalent iodine catalysts. Chemical Society Reviews 51(18), pp. 8102-8139. (10.1039/D2CS00206J)
- Khan, N., Itaya, K. and Wirth, T. 2022. Chiral iodotriptycenes: synthesis and catalytic applications. ChemistryOpen 11(8), article number: e202200158. (10.1002/open.202200158)
- Khan, N., Itaya, K. and Wirth, T. 2022. Chiral iodotriptycenes: Synthesis and catalytic applications. ChemistryOpen 11(7), article number: e202200145. (10.1002/open.202200145)
- Hareram, M. D. et al. 2022. Electrochemical deconstructive functionalization of cycloalkanols via alkoxy radicals enabled by proton-coupled Electron transfer. Organic Letters 24(21), pp. 3890-3895. (10.1021/acs.orglett.2c01552)
- Kaehler, T. et al. 2022. Borane promoted aryl transfer reaction for the synthesis of α-aryl functionalised β-hydroxy and β-keto esters. Organic and Biomolecular Chemistry 20(21), pp. 4298-4302. (10.1039/D2OB00643J)
- Xiong, Z., Weidlich, F., Sanchez, C. and Wirth, T. 2022. Biomimetic total synthesis of (−)-galanthamine via intramolecular anodic aryl–phenol coupling. Organic and Biomolecular Chemistry 20(20), pp. 4123-4127. (10.1039/D2OB00669C)
- Soldatova, N. S. et al. 2022. Zwitterionic iodonium species afford halogen bond-based porous organic frameworks. Chemical Science 13(19), pp. 5650-5658. (10.1039/D2SC00892K)
- Zhang, H. and Wirth, T. 2022. Oxidation of BINOLs by hypervalent iodine reagents: facile synthesis of xanthenes and lactones. Chemistry - A European Journal 28(21) (10.1002/chem.202200181)
- Wirth, T., Patra, T. and Winterson, B. 2022. Hypervalent bromine(III) compounds: synthesis, applications, prospects. Synthesis: Journal of Synthetic Organic Chemistry 54(5), pp. 1261-1271. (10.1055/a-1675-8404)
- Zhang, H., Cormanich, R. A. and Wirth, T. 2022. Chiral ligands in hypervalent iodine compounds: synthesis and structures of binaphthyl-based λ3-iodanes. Chemistry - A European Journal 28(5), article number: e202103623. (10.1002/chem.202103623)
2021
- Amri, N. and Wirth, T. 2021. Flow electrosynthesis of sulfoxides, sulfones, and sulfoximines without supporting electrolytes. Journal of Organic Chemistry 86(22), pp. 15961-15972. (10.1021/acs.joc.1c00860)
- Amri, N. and Wirth, T. 2021. Recent advances in the electrochemical synthesis of organosulfur compounds. Chemical Record 21(9), pp. 2526-2537. (10.1002/tcr.202100064)
- Wirth, T. 2021. Iodine(III) mediators in electrochemical batch and flow reactions. Current Opinion in Electrochemistry 28, article number: 100701. (10.1016/j.coelec.2021.100701)
- Seitz, J. and Wirth, T. 2021. Electrochemical bromofunctionalization of alkenes in a flow reactor. Organic and Biomolecular Chemistry 19(31), pp. 6892-6896. (10.1039/D1OB01302E)
- Winterson, B., Rennigholtz, T. and Wirth, T. 2021. Flow electrochemistry: a safe tool for fluorine chemistry. Chemical Science 12(26), pp. 9053-9059. (10.1039/D1SC02123K)
- Dasgupta, A., Thiehoff, C., Newman, P. D., Wirth, T. and Melen, R. L. 2021. Reactions promoted by hypervalent iodine reagents and boron Lewis acids. Organic and Biomolecular Chemistry 19(22), pp. 4852-4865. (10.1039/D1OB00740H)
- Khan, M. N. and Wirth, T. 2021. Chiral Triptycenes: concepts, progress and prospects. Chemistry - A European Journal 27(24), pp. 7059-7068. (10.1002/chem.202005317)
- Alharbi, H., Elsherbini, M., Qurban, J. and Wirth, T. 2021. C−N axial chiral hypervalent iodine reagents: catalytic stereoselective α‐oxytosylation of ketones. Chemistry - A European Journal 27(13), pp. 4317-4321. (10.1002/chem.202005253)
- Yamamoto Raynbird, M., Khokhar, S., Neef, D., Evans, G. and Wirth, T. 2021. Synthesis of ajoene analogues by novel synthetic strategies. Chemistry - A European Journal 27(9), pp. 3008-3012. (10.1002/chem.202005023)
- Wirth, T. and Zhang, H. 2021. Recent advances in asymmetric functionalization of olefins induced by chiral hypervalent iodine reagents. Chinese Journal of Organic Chemistry 41(1), pp. 65-70. (10.6023/cjoc202006013)
- Elsherbini, M., Osi, A., Alharbi, H., Karam, F. and Wirth, T. 2021. Sulfur-based chiral iodoarenes: an underexplored class of chiral hypervalent iodine reagents. Synthesis: Journal of Synthetic Organic Chemistry 55, pp. 307-314. (10.1055/a-1508-9593)
- Singh, F. V. and Wirth, T. 2021. Hypervalent iodine chemistry and light: photochemical reactions involving hypervalent iodine Chemistry. ARKIVOC 2021(7), pp. 12-47. (10.24820/ark.5550190.p011.483)
2020
- Wirth, T. and Amri, N. 2020. Accelerating electrochemical synthesis through automated flow: efficient synthesis of chalcogenophosphites. SYNLETT 31(19), pp. 1894-1898. (10.1055/s-0040-1707141)
- Hardwick, T., Cicala, R., Wirth, T. and Ahmed, N. 2020. Memory of chirality in a room temperature flow electrochemical reactor. Scientific Reports 10(1), article number: 16627. (10.1038/s41598-020-73957-6)
- Huynh, F., Tailby, M., Finniear, A., Stephens, K., Allemann, R. K. and Wirth, T. 2020. Accelerating biphasic biocatalysis through new process windows. Angewandte Chemie International Edition 59(38), pp. 16490-16495. (10.1002/anie.202005183)
- Elsherbini, M., Huynh, F., Dunbabin, A., Allemann, R. and Wirth, T. 2020. Selective hydroboration - oxidation of terminal alkenes under flow conditions. Chemistry - A European Journal 26(50), pp. 11423-11425. (10.1002/chem.202001650)
- Wirth, T. and Hokamp, T. 2020. Hypervalent iodine(III)‐catalysed enantioselective α‐acetoxylation of ketones. Chemistry - A European Journal 26(46), pp. 10417-10421. (10.1002/chem.202000927)
- Raynbird, M. Y., Silva, F., Smallman, H., Khokhar, S. S., Neef, D., Evans, G. J. S. and Wirth, T. 2020. Short total synthesis of ajoene, (E ,Z )‐4,5,9‐Trithiadodeca‐1,6,11‐triene 9‐oxide, in batch and (E ,Z )‐4,5,9‐Trithiadodeca‐1,7,11‐triene in continuous flow. Chemistry - A European Journal 26(38), pp. 8363-8367. (10.1002/chem.202001598)
- Valikhani, D., Srivastava, P. L., Allemann, R. K. and Wirth, T. 2020. Immobilised enzymes for sesquiterpene synthesis in batch and flow systems. ChemCatChem 12(8), pp. 2194-22197. (10.1002/cctc.201902135)
- Gazis, T. et al. 2020. 1,3-Carboboration of iodonium ylides. Chemical Communications 56, pp. 3345-3348. (10.1039/C9CC08749D)
- Amri, N. and Wirth, T. 2020. Automated electrochemical selenenylations. Synthesis 52(12), pp. 1751-1761. (10.1055/s-0039-1690868)
- Winterson, B. and Wirth, T. 2020. Electrochemistry in flow for drug discovery. In: Topics in Medicinal Chemistry., Vol. 38. Springer, pp. 121-172., (10.1007/7355_2021_115)
2019
- Santi, M., Seitz, J., Cicala, R., Hardwick, T., Ahmed, N. and Wirth, T. 2019. Memory of chirality in flow electrochemistry: fast optimisation with DoE and online 2D-HPLC. Chemistry - A European Journal 25(71), pp. 16230-16235. (10.1002/chem.201904711)
- Elsherbini, M. and Wirth, T. 2019. Electroorganic synthesis under flow conditions. Accounts of Chemical Research 52(12), pp. 3287-3296. (10.1021/acs.accounts.9b00497)
- Allen, B. D. W., Mishra, D., Seastram, A. C., McBride, T., Wirth, T., Browne, D. L. and Morrill, L. C. 2019. Manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols via alkoxy radicals. Organic Letters 21(22), pp. 9241-9246. (10.1021/acs.orglett.9b03652)
- Folgueiras Amador, A. and Wirth, T. 2019. Electrochemistry under flow conditions. In: Luis, S. V. and Garcia-Verdugo, E. eds. Flow Chemistry: Integrated Approaches for Practical Applications. Green Chemistry Series Royal Society of Chemistry, pp. 153-198., (10.1039/9781788016094-00153)
- Elsherbini, M., Allemann, R. K. and Wirth, T. 2019. 'Dark' singlet oxygen made easy. Chemistry - A European Journal 25(54), pp. 12486-12490. (10.1002/chem.201903505)
- Gazis, T. A., Dasgupta, A., Hill, M. S., Rawson, J. M., Wirth, T. and Melen, R. L. 2019. Reactions of hydrazones and hydrazides with Lewis acidic boranes. Dalton Transactions(33), pp. 12391-12395. (10.1039/C9DT01359H)
- Elsherbini, M., Winterson, B., Alharbi, H., Folgueiras Amador, A. A., Genot, C. and Wirth, T. 2019. Continuous electrochemical generator of hypervalent iodine reagents: synthetic applications in flow. Angewandte Chemie International Edition 58(29), pp. 9811-9815. (10.1002/anie.201904379)
- Qurban, J., Elsherbini, M., Alharbi, H. and Wirth, T. 2019. Synthesis, characterisation, and reactivity of novel pseudocyclic hypervalent iodine reagents with heteroaryl carbonyl substituents. Chemical Communications 55, pp. 7998-8000. (10.1039/C9CC03905H)
- Yusubov, M. S. et al. 2019. 2-Iodoxybenzoic acid ditriflate: the most powerful hypervalent iodine(v) oxidant. Chemical Communications 55, pp. 7760-7763. (10.1039/C9CC04203B)
- Hokamp, T. and Wirth, T. 2019. Structurally defined α-Tetralol-Based chiral hypervalent iodine reagents. Journal of Organic Chemistry 84(13), pp. 8674-8682. (10.1021/acs.joc.9b01315)
- Santi, M., Ould, D. M. C., Wenz, J., Soltani, Y., Melen, R. L. and Wirth, T. 2019. Metal-free tandem rearrangement/lactonization: Access to 3,3-disubstituted benzofuran-2-(3H)-ones. Angewandte Chemie International Edition 58(23), pp. 7861-7865. (10.1002/anie.201902985)
- Wirth, T. and Knight, D. 2019. Morpholin-2-one derivatives via intramolecular acid-catalyzed hydroamination. SYNTHESIS 51(7), pp. 1643-1648. (10.1055/s-0037-1610674)
- Singh, F. V. and Wirth, T. 2019. 7. Selenium and tellurium electrophiles in organic synthesis. In: Laitinen, R. and Oilunkaniemi, R. eds. Selenium and Tellurium Reagents: In Chemistry and Materials Science. De Gruyter, pp. 243-300., (10.1515/9783110529340-007)
- Amri, N., Skilton, R., Guthrie, D. and Wirth, T. 2019. Efficient flow electrochemical alkoxylation of N-formylpyrrolidine. SYNLETT 30(10), pp. 1183-1186. (10.1055/s-0037-1611774)
- Soldatova, N. S., Postnikov, P. S., Yusubov, M. S. and Wirth, T. 2019. Flow synthesis of iodonium trifluoroacetates through direct oxidation of iodoarenes by Oxone®. European Journal of Organic Chemistry 2019(10), pp. 2081-2088. (10.1002/ejoc.201900220)
- Singh, F. V. and Wirth, T. 2019. Selenium reagents as catalysts. Catalysis Science & Technology 9(5), pp. 1073-1091. (10.1039/C8CY02274G)
2018
- Wirth, T. 2018. Organoselenium chemistry. In: Encyclopedia of Inorganic and Bioinorganic Chemistry. Wiley, (10.1002/9781119951438.eibc2727)
- Islam, M., Kariuki, B. M., Shafiq, Z., Wirth, T. and Ahmed, N. 2018. Efficient electrosynthesis of thiazolidin-2-imines via oxysulfurization of thiourea-tethered terminal alkenes using the flow microreactor. European Journal of Organic Chemistry (10.1002/ejoc.201801688)
- Wirth, T., Gao, W., Xiong, Z. and Pirhaghani, S. 2018. Enantioselective electrochemical lactonization using chiral iodoarenes as mediators. Synthesis (Stuttgart) (10.1055/s-0037-1610373)
- Silva, F., Khokhar, S. S., Williams, D. M., Saunders, R., Evans, G. J. S., Graz, M. and Wirth, T. 2018. Short total synthesis of ajoene. Angewandte Chemie International Edition 57(38), pp. 12290-12293. (10.1002/anie.201808605)
- Elsherbini, M. and Wirth, T. 2018. Hypervalent iodine reagents by anodic oxidation: a powerful green synthesis. Chemistry - a European Journal 24(51), pp. 13399-13407. (10.1002/chem.201801232)
- Mironova, I. A. et al. 2018. Preparation and X-ray structure of 2-iodoxybenzenesulfonic acid (IBS) - a powerful hypervalent iodine(V) oxidant. Beilstein Journal of Organic Chemistry 14, pp. 1854-1858. (10.3762/bjoc.14.159)
- Hokamp, T., Mollari, L., Wilkins, L. C., Melen, R. L. and Wirth, T. 2018. Alternative strategies with iodine: fast access to previously inaccessible iodine(III) compounds. Angewandte Chemie International Edition 57(27), pp. 8306-8309. (10.1002/anie.201804642)
- Elsherbini, M. and Wirth, T. 2018. Mechanochemical synthesis of N-tert-butanesulfinyl imines under metal-free conditions. Tetrahedron 74(25), pp. 3101-3106. (10.1016/j.tet.2017.11.028)
- Singh, F. V. and Wirth, T. 2018. Stereoselective reactions. In: PATAI's Chemistry of Functional Groups. John Wiley, (10.1002/9780470682531.pat0957)
- Silva, F. et al. 2018. Selective oxidation of sulfides in flow chemistry. European Journal of Organic Chemistry 2018(18), pp. 2134-2137. (10.1002/ejoc.201800339)
- Soldatova, N., Postnikov, P., Kukurina, O., Zhdankin, V. V., Yoshimura, A., Wirth, T. and Yusubov, M. S. 2018. One-pot synthesis of diaryliodonium salts from arenes and aryl iodides with Oxone-sulfuric acid. Beilstein Journal of Organic Chemistry 14, pp. 849-855. (10.3762/bjoc.14.70)
- Yusubov, M. et al. 2018. Reactions of 1-arylbenziodoxolones with azide anion: Experimental and computational study of substituent effects. European Journal of Organic Chemistry 2018(5), pp. 640-647. (10.1002/ejoc.201701595)
- Folgueiras-Amador, A. A., Qian, X., Xu, H. and Wirth, T. 2018. Catalyst- and supporting electrolyte-free electrosynthesis of benzothiazoles and thiazolopyridines in continuousf flow. Chemistry - A European Journal 24(2), pp. 487-491. (10.1002/chem.201705016)
- Wirth, T., Hokamp, T., Storm, A. and Yusubov, M. 2018. Iodine monoacetate for efficient oxyiodinations of alkenes and alkynes. Synlett 29(4), pp. 415-418. (10.1055/s-0036-1589119)
2017
- Wirth, T. 2017. Integration of flow chemistry in multistep syntheses. European Journal of Organic Chemistry 2017(44), pp. 6464. (10.1002/ejoc.201701543)
- Folgueiras-Amador, A. A., Philipps, K., Guilbaud, S., Poelakker, J. and Wirth, T. 2017. An easy-to-machine electrochemical flow microreactor: efficient synthesis of isoindolinone and flow functionalization. Angewandte Chemie International Edition 56(48), pp. 15446-15450. (10.1002/anie.201709717)
- Wirth, T. 2017. Thomas Wirth. European Journal of Organic Chemistry 2017(44), pp. 6465-6464. (10.1002/ejoc.201701545)
- Wirth, T. 2017. Organic synthesis in flow for medicinal chemistry. Bioorganic & Medicinal Chemistry 25(23), pp. 6179. (10.1016/j.bmc.2017.11.013)
- Aldmairi, A. H., Knight, D. and Wirth, T. 2017. Acid-catalyzed tandem process for the one-pot synthesis of oxazolidines. Synlett 28(20), pp. 2976-2978. (10.1055/s-0036-1591513)
- Wirth, T. and Singh, F. V. 2017. 2.2 Catalytic oxidations with hypervalent iodine. In: Muniz, K. ed. Science of Synthesis: Catalytic Oxidation in Organic Synthesis. Thieme, pp. 29-62.
- Qurban, J., Elsherbini, M. and Wirth, T. 2017. Electron-deficient chiral lactic acid-based hypervalent iodine reagents. Journal of Organic Chemistry 82(22), pp. 11872-11876. (10.1021/acs.joc.7b01571)
- Folgueiras-Amador, A. and Wirth, T. 2017. Perspectives in flow electrochemistry. Journal of Flow Chemistry 7(3-4), pp. 94-95. (10.1556/1846.2017.00020)
- Santi, M., Müller, S. T. R., Folgueiras-Amador, A., Uttry, A., Hellier, P. and Wirth, T. 2017. Enantioselective synthesis of trans-2,3-Dihydro-1H-indoles through C-H Insertion of a-Diazocarbonyl compounds. European Journal of Organic Chemistry 2017(14), pp. 1889-1893. (10.1002/ejoc.201700412)
- Tang, X., Demiray, M., Wirth, T. and Allemann, R. K. 2017. Concise synthesis of artemisinin from a farnesyl diphosphate analogue. Bioorganic & Medicinal Chemistry 26(7), pp. 1314-1319. (10.1016/j.bmc.2017.03.068)
- Demiray, M., Tang, X., Wirth, T., Faraldos, J. A. and Allemann, R. K. 2017. An efficient chemoenzymatic synthesis of dihydroartemisinic aldehyde. Angewandte Chemie International Edition 56(15), pp. 4347-4350. (10.1002/anie.201609557)
- Demiray, M., Tang, X., Wirth, T., Faraldos, J. A. and Allemann, R. K. 2017. Effiziente chemoenzymatische Synthese von dhydroartemisinaldehyd. Angewandte Chemie 129(15), pp. 4411-4415. (10.1002/ange.201609557)
- Wirth, T. 2017. Novel organic synthesis through ultrafast chemistry. Angewandte Chemie - International Edition 56(3), pp. 682-684. (10.1002/anie.201609595)
- Wirth, T. 2017. Neue organische synthesen durch ultraschnelle chemie. Angewandte Chemie 129(3), pp. 698-700. (10.1002/ange.201609595)
- Tang, X., Allemann, R. K. and Wirth, T. 2017. Optimising terpene synthesis with flow biocatalysis. European Journal of Organic Chemistry 2017(2), pp. 414-418. (10.1002/ejoc.201601388)
- Malmedy, F. and Wirth, T. 2017. Cyclization of malonate derivatives with iodine(III) reagents. European Journal of Organic Chemistry (10.1002/ejoc.201601587)
- Wirth, T. and Mizar, P. 2017. Iodoaminations of alkenes. Synthesis 49(5), pp. 981-986. (10.1055/s-0036-1588630)
- Wirth, T. 2017. 35.1.5.1.12 Synthesis of 1-Chloro-n-Heteroatom-Functionalized Alkanes (n ≥2) by Addition across C=C Bonds. In: Science of Synthesis Knowledge Updates 2017/1. Georg Thieme Verlag KG, pp. 403-442., (10.1055/sos-SD-135-00173)
- Wirth, T. 2017. 4.4.19.4 Silyl Sulfides and Selenides. In: Science of Synthesis Knowledge Updates 2017/1., Vol. 1. Georg Thieme Verlag KG, pp. 189-202., (10.1055/sos-SD-104-00365)
2016
- Soldatova, N., Postnikov, P., Kukurina, O., Zhdankin, V. V., Yoshimura, A., Wirth, T. and Yusubov, M. S. 2016. Facile one-pot synthesis of diaryliodonium salts from arenes and aryl iodides with oxone. ChemistryOpen (10.1002/open.201600129)
- Hutchings, M. and Wirth, T. 2016. Safe use of nitromethane for aldol reactions in flow. Journal of Flow Chemistry 6(3), pp. 202-205. (10.1556/1846.2016.00022)
- Malmedy, F. and Wirth, T. 2016. Stereoselective ketone rearrangements with hypervalent iodine reagents. Chemistry - a European Journal 22(45) (10.1002/chem.201603022)
- Malmedy, F. and Wirth, T. 2016. Frontispiece: stereoselective ketone rearrangements with hypervalent iodine reagents. Chemistry - a European Journal 22(45), pp. 16072-16077. (10.1002/chem.201684562)
- Wilkins, L. C., Gunther, B. A. R., Walther, M., Lawson, J. R., Wirth, T. and Melen, R. L. 2016. Contrasting frustrated Lewis pair reactivity with selenium- and boron-based Lewis acids. Angewandte Chemie International Edition 55(37), pp. 11292-11295. (10.1002/anie.201605239)
- Wilkins, L., Günther, B. A., Walther, M., Lawson, J., Wirth, T. and Melen, R. 2016. Gegensätzliche Reaktivität frustrierter Lewis-Paare mit Selen- und Bor-basierten Lewis-Säuren. Angewandte Chemie 128(37), pp. 11462-11465. (10.1002/ange.201605239)
- Müller, S. T. R., Hokamp, T., Ehrmann, S., Hellier, P. and Wirth, T. 2016. Ethyl lithiodiazoacetate: extremely unstable intermediate handled efficiently in flow. Chemistry: A European Journal 22(34), pp. 11940-11942. (10.1002/chem.201602133)
- Wirth, T. and Hutchings, M. 2016. A simple setup for transfer hydrogenations in flow chemistry. Synlett 27(12), pp. 1832-1835. (10.1055/s-0035-1561624)
- Brown, M., Kumar, R., Rehbein, J. and Wirth, T. 2016. Enantioselective oxidative rearrangements with chiral hypervalent iodine reagents. Chemistry - a European Journal 22(12), pp. 4030-4035. (10.1002/chem.201504844)
- Mueller, S. T. R., Murat, A., Hellier, P. and Wirth, T. 2016. Toward a large-scale approach to milnacipran analogues using diazo compounds in flow chemistry. Organic Process Research and Development 20(2), pp. 495-502. (10.1021/acs.oprd.5b00308)
- Mizar, P., Niebuhr, R., Hutchings, M., Farooq, U. and Wirth, T. 2016. Thioamination of alkenes with hypervalent iodine reagents. Chemistry - a European Journal 22(5), pp. 1614-1617. (10.1002/chem.201504636)
2015
- Edwards, R., de Vries, W., Westwell, A. D., Daniels, S. and Wirth, T. 2015. Solid-supported iodonium salts for fluorinations. European Journal of Organic Chemistry 2015(31), pp. 6909-6916. (10.1002/ejoc.201500992)
- Muller, S. T. R., Murat, A., Hellier, P. and Wirth, T. 2015. Safe handling of diazo reagents through inline analytics and flow chemistry. Chimica Oggi 33(5), pp. 74-77.
- Wirth, T. 2015. Kleine Organoselenverbindungen: mehr als nur Mimetika der Glutathion-Peroxidase. Angewandte Chemie 127(35), pp. 10212-10214. (10.1002/ange.201505056)
- Wirth, T. 2015. Small organoselenium compounds: more than just glutathione peroxidase mimics. Angewandte Chemie - International Edition 54(35), pp. 10074-10076. (10.1002/anie.201505056)
- Baker, A., Graz, M., Saunders, R., Evans, G. J. S., Pitotti, I. and Wirth, T. 2015. Flow alkylation of thiols, phenols, and amines using a heterogenous base in a packed-bed reactor. Journal of Flow Chemistry 5(2), pp. 65. (10.1556/1846.2015.00009)
- Tancock, J. and Wirth, T. 2015. Selenium-mediated synthesis of tetrasubstituted naphthalenes through rearrangement. Molecules 20(6), pp. 10866-10872. (10.3390/molecules200610866)
- Kumar, R. and Wirth, T. 2015. Asymmetric synthesis with hypervalent iodine reagents. Topics in Current Chemistry, pp. 1-19. (10.1007/128_2015_639)
- Edwards, R. and Wirth, T. 2015. [18F]6-fluoro-3,4-dihydroxy-l-phenylalanine - recent modern syntheses for an elusive radiotracer. Journal of Labelled Compounds and Radiopharmaceuticals 58(5), pp. 183-187. (10.1002/jlcr.3285)
- Muller, S. T. R., Murat, A., Maillos, D., Lesimple, P., Hellier, P. and Wirth, T. 2015. Rapid generation and safe use of carbenes enabled by a novel flow protocol with in-line IR spectroscopy. Chemistry - A European Journal 21(19), pp. 7016-7020. (10.1002/chem.201500416)
- Müller, S. T. R. and Wirth, T. 2015. Diazo compounds in continuous-flow technology. Chemsuschem 8(2), pp. 245-250. (10.1002/cssc.201402874)
- Edwards, R., Westwell, A. D., Daniels, S. and Wirth, T. 2015. Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA. European Journal of Organic Chemistry 2015(3), pp. 625-630. (10.1002/ejoc.201403378)
- Wirth, T., Brown, M., Delorme, M., Malmedy, F., Malmgren, J. and Olofsson, B. 2015. Synthesis of new chiral diaryliodonium salts. Synlett 26(11), pp. 1573-1577. (10.1055/s-0034-1380687)
- Wirth, T. and Singh, F. V. 2015. Synthesis by substitution of other halogens. In: Science of Synthesis Knowledge Updates: 2015/2. Thieme, pp. 407-414.
- Wirth, T. and Singh, F. V. 2015. Synthesis by substitution of oxygen functionalities. In: Science of Synthesis Knowledge Updates: 2015/2. Thieme, pp. 415-435.
2014
- Attah Egu, S., Okoro, U. and Wirth, T. 2014. Synthesis of quinolinequinone derivatives and related carbocyclic compounds. ScienceOpen Research (10.14293/S2199-1006.1.SOR-CHEM.AALL9P.v1)
- Ambreen, N. and Wirth, T. 2014. High-temperature synthesis of amides from alcohols or aldehydes by using flow chemistry. European Journal of Organic Chemistry 2014(34), pp. 7590-7593. (10.1002/ejoc.201403280)
- Elsherbini, M. S., Hamama, W. S., Zoorob, H. H., Bhowmick, D., Mugesh, G. and Wirth, T. 2014. Synthesis and antioxidant activities of novel chiral ebselen analogues. Heteroatom Chemistry 25(5), pp. 320-325. (10.1002/hc.21164)
- Mizar, P., Burrelli, A., Gunther, E., Softje, M., Farooq, U. and Wirth, T. 2014. Organocatalytic stereoselective iodoamination of alkenes. Chemistry - a European Journal 20(41), pp. 13113-13116. (10.1002/chem.201404762)
- Mizar, P., Laverny, A., El-Sherbini, M., Farid, U., Brown, M., Malmedy, F. and Wirth, T. 2014. Enantioselective diamination with novel chiral hypervalent iodine catalysts. Chemistry - A European Journal 20(32), pp. 9910-9913. (10.1002/chem.201403891)
- Arai, K. and Wirth, T. 2014. Rapid electrochemical deprotection of the isonicotinyloxycarbonyl group from carbonates and thiocarbonates in a microfluidic reactor. Organic Process Research and Development, article number: 140708073813000. (10.1021/op500155f)
- Mizar, P. and Wirth, T. 2014. Flexible stereoselective functionalizations of ketones through umpolung with hypervalent iodine reagents. Angewandte Chemie International Edition 53(23), pp. 5993-5997. (10.1002/anie.201400405)
- Mizar, P. and Wirth, T. 2014. Flexible stereoselektive Funktionalisierung von Ketonen durch Umpolung mit hypervalenten Iodreagentien. Angewandte Chemie 126(23), pp. 6103-6107. (10.1002/ange.201400405)
- Muller, S. T. R., Smith, D., Hellier, P. and Wirth, T. 2014. Safe generation and direct use of diazoesters in flow chemistry. Synlett 25(6), pp. 871-875. (10.1055/s-0033-1340835)
- Arai, K., Watts, K. and Wirth, T. 2014. Difluoro- and trifluoromethylation of electron-deficient alkenes in an electrochemical microreactor. ChemistryOpen 3(1), pp. 23-28. (10.1002/open.201300039)
- Watts, K., Baker, A. R. and Wirth, T. 2014. Electrochemical synthesis in microreactors. Journal of Flow Chemistry 4(1), pp. 2-11. (10.1556/JFC-D-13-00030)
- Singh, F. V. and Wirth, T. 2014. 7.29 oxidative functionalization with hypervalent halides. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 7, pp. 880-933. (10.1016/B978-0-08-097742-3.00735-7)
- Singh, F. V. and Wirth, T. 2014. Hypervalent iodine-catalyzed oxidative functionalizations including stereoselective reactions. Chemistry - An Asian Journal 9(4), pp. 950-971. (10.1002/asia.201301582)
2013
- Baker, A. R., Graz, M., Saunders, R., Evans, G. J. S., Kaul, S. and Wirth, T. 2013. Flow synthesis of symmetrical di- and trisulfides using phase-transfer catalysis. Journal of Flow Chemistry 3(4), pp. 118-121. (10.1556/JFC-D-13-00013)
- Cascón, O., Richter, G., Allemann, R. K. and Wirth, T. 2013. Efficient terpene synthase catalysis by extraction in flow. ChemPlusChem 78(11), pp. 1334-1337. (10.1002/cplu.201300303)
- Singh, F. V. and Wirth, T. 2013. Oxidative rearrangements with hypervalent iodine reagents. Synthesis (Stuttgart) 45(18), pp. 2499-2511. (10.1055/s-0033-1339679)
- Farid, U., Malmedy, F., Claveau, R., Albers, L. and Wirth, T. 2013. Stereoselective rearrangements with chiral hypervalent iodine reagents. Angewandte Chemie - International Edition 52(27), pp. 7018-7022. (10.1002/anie.201302358)
- König, B., Kreitmeier, P., Hilgers, P. and Wirth, T. 2013. Flow chemistry in undergraduate organic chemistry education. Journal of Chemical Education 90(7), pp. 934-936. (10.1021/ed3006083)
- Brown, M., Farid, U. and Wirth, T. 2013. Hypervalent iodine reagents as powerful electrophiles. Synlett 24(4), pp. 424-431. (10.1055/s-0032-1318103)
- Farid, U., Malmedy, F., Claveau, R., Albers, L. and Wirth, T. 2013. Stereoselektive Umlagerungen mit chiralen hypervalenten Iodreagentien. Angewandte Chemie 125(27), pp. 7156-7160. (10.1002/ange.201302358)
- Ambreen, N., Kumar, R. and Wirth, T. 2013. Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation. Beilstein Journal of Organic Chemistry 9, pp. 1437-1442. (10.3762/bjoc.9.162)
2012
- Singh, F. V., Rehbein, J. and Wirth, T. 2012. Facile oxidative rearrangements using hypervalent iodine reagents. ChemistryOpen 1(6), pp. 245-250. (10.1002/open.201200037)
- Gabriele, E., Singh, F. V., Freudendahl, D. M. and Wirth, T. 2012. Selenenylations of alkenes with styrene nucleophiles. Tetrahedron 68(51), pp. 10573-10576. (10.1016/j.tet.2012.08.034)
- Santi, C., Di Lorenzo, R., Tidei, C., Bagnoli, L. and Wirth, T. 2012. Stereoselective selenium catalyzed dihydroxylation and hydroxymethoxylation of alkenes. Tetrahedron 68(51), pp. 10530-10535. (10.1016/j.tet.2012.08.078)
- Wirth, T. and Farid, U. 2012. Stereoselective synthesis with hypervalent iodine reagents. In: Christmann, M. and Bräse, S. eds. Asymmetric Synthesis II. Wiley-VCH, pp. 197-203.
- Farid, U. and Wirth, T. 2012. 5,6,7,8-Tetrafluoro-1-hydroxy-1-oxobenziodoxol-3(1H)one (Tetrafluoro-IBX). e-EROS: Encyclopedia of Reagents for Organic Synthesis, article number: rn01489. (10.1002/047084289X.rn01489)
- Wirth, T. 2012. Flow chemistry: enabling technology in drug discovery and process research [Editorial]. ChemSusChem 5(2), pp. 215-216. (10.1002/cssc.201200061)
- Singh, F. V. and Wirth, T. 2012. Hypervalent iodine mediated oxidative cyclization of o-hydroxystilbenes into benzo- and naphthofurans. Synthesis (Stuttgart) 44(8), pp. 1171-1177. (10.1055/s-0031-1290588)
- Martínez-Máñez, R. and Wirth, T. 2012. Opening up the world of chemistry [Editorial]. ChemistryOpen 1(1), pp. 4. (10.1002/open.201100009)
- Audiger, L. E., Watts, K., Elmore, S. C., Robinson, R. I. and Wirth, T. 2012. Ritter reactions in flow. ChemSusChem 5(2), pp. 257-260. (10.1002/cssc.201100372)
- Zhao, L., Li, J., Li, Y., Liu, J., Wirth, T. and Li, Z. 2012. Selenium-containing naphthalimides as anticancer agents: Design, synthesis and bioactivity. Bioorganic and Medicinal Chemistry 20(8), pp. 2558-2563. (10.1016/j.bmc.2012.02.049)
- Farid, U. and Wirth, T. 2012. Highly stereoselective metal-free oxyaminations using chiral hypervalent iodine reagents. Angewandte Chemie. International Edition 51(14), pp. 3462-3465. (10.1002/anie.201107703)
- Farid, U. and Wirth, T. 2012. Innenrücktitelbild: stereoselektive metallfreie oxyaminierungen mit chiralen hypervalenten iodreagentien (Angew. Chem. 14/2012). Angewandte Chemie 124(14), pp. 3549. (10.1002/ange.201201230)
- Farid, U. and Wirth, T. 2012. Inside back cover: highly stereoselective metal-free oxyaminations using chiral hypervalent iodine reagents (Angew. Chem. Int. Ed. 14/2012). Angewandte Chemie - International Edition 51(14), pp. 3491. (10.1002/anie.201201230)
2011
- Zhao, L., Li, Z. and Wirth, T. 2011. Asymmetric Methoxyselenenylations with Chiral Selenium Electrophiles. European Journal of Organic Chemistry 2011(35), pp. 7080-7082. (10.1002/ejoc.201101373)
- Watts, K., Gattrell, W. and Wirth, T. 2011. A practical microreactor for electrochemistry in flow. Beilstein Journal of Organic Chemistry 7, pp. 1108-1114. (10.3762/bjoc.7.127)
- Rasheed, M. and Wirth, T. 2011. Fast optimisation of a Diels-Alder reaction in a flow microreactor by in-line HPLC analysis. Chimica Oggi - Chemistry Today 29(3), pp. 53-55.
- Wirth, T. and Zanda, M. 2011. SYNTHESIS/SYNLETT Advisory Board Focus: Professor Thomas Wirth (Cardiff University, UK) [Interview]. Synthesis -Stuttgart-(5), pp. A26-A26. (10.1055/s-0030-1259586)
- Ahmed-Omer, B., Barrow, D. A. and Wirth, T. 2011. Multistep reactions using microreactor chemistry. Arkivoc Online Journal of Organic Chemistry(4), pp. 26-36.
- Zhao, L., Li, Z. and Wirth, T. 2011. Preparation of Novel Chiral Non-Racemic Diselenides and Applications in Asymmetric Synthesis. European Journal of Organic Chemistry(1), pp. 176-182. (10.1002/ejoc.201001272)
- Rasheed, M. and Wirth, T. 2011. Intelligent Microflow: Development of Self-Optimizing Reaction Systems. Angewandte Chemie - International Edition 50(2), pp. 357-358. (10.1002/anie.201006107)
- Wirth, T. 2011. Professor Siegfried Blechert: A Tribute. Arkivoc Online Journal of Organic Chemistry(4), pp. 1-5.
- Wirth, T. ed. 2011. Organoselenium chemistry: Synthesis and reactions. Weinheim: Wiley-VCH.
- Singh, F. V. and Wirth, T. 2011. Selenium compounds as ligands and catalysts. In: Wirth, T. ed. Organoselenium Chemistry: Synthesis and Reactions. Weinheim: Wiley-VCH, pp. 321-360.
- Freudendahl, D. M. and Wirth, T. 2011. New selenium electrophiles and their reactivity. In: Woollins, J. D. and Laitinen, R. eds. Selenium and Tellurium Chemistry: From Small Molecules to Biomolecules and Materials. London: Springer, pp. 41-56.
- Singh, F. V. and Wirth, T. 2011. Selenium-catalyzed regioselective cyclization of unsaturated carboxylic acids using hypervalent iodine oxidants. Organic Letters 13(24), pp. 6504-6507. (10.1021/ol202800k)
- Rasheed, M., Elmore, S. C. and Wirth, T. 2011. Asymmetric reactions in flow reactors. In: Gruttadauria, M. and Giacalone, F. eds. Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications. Hoboken: Wiley, pp. 345-371., (10.1002/9781118087992.ch8)
- Singh, F. V. and Wirth, T. 2011. Stereoselective reactions of organoselenium reagents including catalysis. In: Patai's Chemistry of Functional Groups. John Wiley & Sons, (10.1002/9780470682531.pat0573)
2010
- Brandt, J. C., Elmore, S. C., Robinson, R. I. and Wirth, T. 2010. Safe and Efficient Ritter Reactions in Flow. Synlett(20), pp. 3099-3103. (10.1055/s-0030-1259075)
- Luk, Y., Allender, C. J. and Wirth, T. 2010. Molecular imprinted polymers binding low functionality templates. Tetrahedron Letters 51(45), pp. 5883-5885. (10.1016/j.tetlet.2010.08.108)
- Khan, Z. A., Iwaoka, M. and Wirth, T. 2010. Novel cyclization cascades to functionalized indanes and tetrahydronaphthalenes. Tetrahedron 66(33), pp. 6639-6646. (10.1016/j.tet.2010.03.062)
- Zhao, L. W., Li, Z. and Wirth, T. 2010. Triptycene Derivatives: Synthesis and Applications. Chemistry Letters 39(7), pp. 658-667.
- Freudendahl, D. M., Iwaoka, M. and Wirth, T. 2010. Synthesis of New Sulfoxide-Containing Diselenides and Unexpected Cyclization Reactions to 2,3-Dihydro-1,4-benzoselenothiine 1-Oxides. European Journal of Organic Chemistry(20), pp. 3934-3944. (10.1002/ejoc.201000514)
- Altermann, S., Schafer, S. and Wirth, T. 2010. New chiral hypervalent iodine(V) compounds as stoichiometric oxidants. Tetrahedron 66(31), pp. 5902-5907. (10.1016/j.tet.2010.05.079)
- Quideau, S. and Wirth, T. 2010. Hypervalent iodine chemistry-recent advances and applications [Preface]. Tetrahedron 66(31), pp. 5737-5738. (10.1016/j.tet.2010.06.026)
- Shahzad, S. A., Venin, C. and Wirth, T. 2010. Diselenide- and Disulfide-Mediated Synthesis of Isocoumarins. European Journal of Organic Chemistry(18), pp. 3465-3472. (10.1002/ejoc.201000308)
- Farooq, U., Schäfer, S., Shah, A., Freudendahl, D. M. and Wirth, T. 2010. Synthesis of new enantiomerically pure organoiodine catalysts and their application in the alpha-functionalization of ketones. Synthesis -Stuttgart-(6), pp. 1023-1029. (10.1055/s-0029-1218640)
- Shahzad, S. A., Vivant, C. and Wirth, T. 2010. Selenium-Mediated Synthesis of Biaryls through Rearrangement. Organic Letters 12(6), pp. 1364-1367. (10.1021/ol100274e)
- Schäfer, S. and Wirth, T. 2010. A versatile and highly reactive polyfluorinated hypervalent iodine(III) compound. Angewandte Chemie. International Edition 49(15), pp. 2786-2789. (10.1002/anie.200907134)
- Ogura, F., Otsubo, T., Wirth, T. and Khan, Z. A. 2010. Dimethyl selenoxide. In: Paquette, L. A. ed. E-EROS encyclopedia of reagents for organic synthesis. Chichester: Wiley
2009
- Ahmed-Omer, B., Barrow, D. A. and Wirth, T. 2009. Heck reactions using segmented flow conditions. Tetrahedron Letters 50(26), pp. 3352-3355. (10.1016/j.tetlet.2009.02.133)
- Brandt, J. C. and Wirth, T. 2009. Controlling hazardous chemicals in microreactors: Synthesis with iodine azide. Beilstein Journal of Organic Chemistry 5(30) (10.3762/bjoc.5.30)
- Freudendahl, D. M., Shahzad, S. A. and Wirth, T. 2009. Recent Advances in Organoselenium Chemistry. European Journal of Organic Chemistry(11), pp. 1649-1664. (10.1002/ejoc.200801171)
- Khan, Z. A. and Wirth, T. 2009. Synthesis of Indene Derivatives via Electrophilic Cyclization. Organic Letters 11(1), pp. 229-231. (10.1021/ol8024956)
- Shah, A. et al. 2009. Iodoxolone-Based Hypervalent Iodine Reagents. Organic Letters 11(16), pp. 3578-3581. (10.1021/ol9014688)
- Shahzad, S. A. and Wirth, T. 2009. Fast synthesis of benzofluorenes by selenium-mediated carbocyclizations. Angewandte Chemie. International Edition 48(14), pp. 2588-2591. (10.1002/anie.200806148)
- Farooq, U., Shah, A. and Wirth, T. 2009. Hypervalent Bromine Compounds: Smaller, More Reactive Analogues of Hypervalent Iodine Compounds. Angewandte Chemie - International Edition 48(6), pp. 1018-1020. (10.1002/anie.200805027)
- Freudendahl, D. M., Santoro, S., Shahzad, S. A., Santi, C. and Wirth, T. 2009. Green Chemistry with Selenium Reagents: Development of Efficient Catalytic Reactions. Angewandte Chemie - International Edition 48(45), pp. 8409-8411. (10.1002/anie.200903893)
- Uehlin, L. and Wirth, T. 2009. Synthesis of Chiral Acetals by Asymmetric Selenenylations. Phosphorus Sulfur and Silicon and the Related Elements 184(6), pp. 1374-1385. (10.1080/10426500902930167)
- Brandt, J. C. and Wirth, T. 2009. Homogeneous catalysis using microreactor technology. In: Benaglia, M. ed. Recoverable and Recyclable Catalysts. Oxford: Wiley, pp. 411-425., (10.1002/9780470682005.ch14)
- Choi, J., Shahzad, S. A. and Wirth, T. 2009. Dimethylaluminium methylselenolate. In: Paquette, L. A. ed. Encyclopedia of reagents for organic synthesis (e-EROS). Chichester: Wiley, (10.1002/047084289X.rd300.pub2)
- Marino, J. P., Holub, D. P., Shahzad, S. A. and Wirth, T. 2009. Diphenylselenium bis(trifluoroacetate). In: Paquette, L. A. ed. E-EROS Encyclopedia of Reagents for Organic Synthesis. Chichester: Wiley
- Simpkins, N. S. and Wirth, T. 2009. tert-Butyl Hypoiodite. In: Paquette, L. A. ed. Encyclopedia of Reagents for Organic Synthesis (EROS). 2nd ed.. Chichester: Wiley
2008
- Altermann, S. M. et al. 2008. Catalytic Enantioselective alpha-Oxysulfonylation of Ketones Mediated by Iodoarenes. European Journal of Organic Chemistry(31), pp. 5315-5328. (10.1002/ejoc.200800741)
- Browne, D. M., Niyomura, O. and Wirth, T. 2008. Catalytic addition-elimination reactions towards butenolides. Phosphorus Sulfur and Silicon and the Related Elements 183(4), pp. 1026-1035. (10.1080/10426500801901053)
- Ahmed-Omer, B., Barrow, D. A. and Wirth, T. 2008. Effect of segmented fluid flow, sonication and phase transfer catalysis on biphasic reactions in capillary microreactors. Chemical Engineering Journal 135(S1), pp. S280-S283. (10.1016/j.cej.2007.07.017)
- Wirth, T. 2008. Enhancement of reaction rates by segmented flow technique: New aspects for organic synthesis. Presented at: 1st SynTOP conference, Potsdam, Germany, 1-13 June 2008Smart synthesis and technologies for organic processes : 1st SynTOP conference, Potsdam, June 11 - 13, 2008. VDI-Berichte Vol. 2039. Düsseldorf: VDI-Verl. pp. 103-104.
- Richardson, R. D. and Wirth, T. 2008. Tetraazafulvalene: "Organisches" Natrium. Chemie in unserer Zeit 42(3), pp. 190-191. (10.1002/ciuz.200890032)
- Wirth, T. ed. 2008. Microreactors in organic synthesis and catalysis. Weinheim: Wiley-VCH.
- Ahmed-Omer, B. and Wirth, T. 2008. Liquid-liquid biphasic reactions. In: Wirth, T. ed. Microreactors in Organic Synthesis and Catalysis. Weinheim: Wiley-VCH, pp. 122-139., (10.1002/9783527622856.ch4)
- Maruoka, K., Yamamoto, H., Wirth, T. and Khan, Z. A. 2008. Diisobutylaluminium phenyl selenide. In: Paquette, L. A. ed. e-EROS encyclopedia of reagents for organic synthesis. Chichester: Wiley
2007
- Browne, D. M., Niyomura, O. and Wirth, T. 2007. Catalytic use of selenium electrophiles in cyclizations. Organic Letters 9(16), pp. 3169-3171. (10.1021/ol071223y)
- Richardson, R. D., Zayed, J. M., Altermann, S., Smith, D. and Wirth, T. 2007. Tetrafluoro-IBA and -IBX: Hypervalent Iodine Reagents. Angewandte Chemie - International Edition 46(34), pp. 6529-6532. (10.1002/anie.200702313)
- Simmons, S. J., French, A. N., Richardson, R. D. and Wirth, T. 2007. Attempted aziridinations and sulfonilimations using simple iron catalysts and hypervalent iodine reagents. Abstracts of Papers of the American Chemical Society 233, pp. 253-253.
- Paradine, S. M., French, A. N., Page, T. K., Richardson, R. D. and Wirth, T. 2007. Catalytic enantioselective alpha-oxytosylation of propiophenone using chiral hypervalent iodine reagents. Abstracts of Papers of the American Chemical Society 233, pp. 211-211.
- Burgler, F. W., Fragale, G. and Wirth, T. 2007. Stereoselective addition reactions with chalcogen electrophiles. Arkivoc(x), pp. 21-28.
- Ahmed-Omer, B., Brandt, J. C. and Wirth, T. 2007. Advanced organic synthesis using microreactor technology. Organic & Biomolecular Chemistry 5(5), pp. 733-740. (10.1039/B615072A)
- Richardson, R. D., Desaize, M. and Wirth, T. 2007. Hypervalent iodine-mediated aziridination of alkenes: Mechanistic insights and requirements for catalysis. Chemistry - A European Journal 13(23), pp. 6745-6754. (10.1002/chem.200700306)
2006
- Ahmed, B., Barrow, D. A. and Wirth, T. 2006. Enhancement of reaction rates by segmented fluid flow in capillary scale reactors. Advanced Synthesis & Catalysis 348(9), pp. 1043-1048. (10.1002/adsc.200505480)
- Niyomura, O., Cox, M. and Wirth, T. 2006. Electrochemical generation and catalytic use of selenium electrophiles. Synlett(2), pp. 251-254. (10.1055/s-2005-923585)
2005
- Haas, J., Bissmire, S. and Wirth, T. 2005. Iodine Monochloride-Amine Complexes: An Experimental and Computational Approach to New Chiral Electrophiles. Chemistry - A European Journal 11(19), pp. 5777-5785. (10.1002/chem.200500507)
- Yusubov, M. S. and Wirth, T. 2005. Solvent-free reactions with hypervalent iodine reagents. Organic Letters 7(3), pp. 519-521. (10.1021/ol047363e)
- Wirth, T. 2005. Hypervalent iodine chemistry in synthesis: Scope and new directions. Angewandte Chemie - International Edition 44(24), pp. 3656-3665. (10.1002/anie.200500115)
2004
- French, A. N., Cole, J. and Wirth, T. 2004. Tetrahydrofuranylation of alcohols using hypervalent iodine reagents. Synlett(13), pp. 2291-2294. (10.1055/s-2004-832810)
- Khokhar, S. S. and Wirth, T. 2004. Nucleophile-selective selenocyclizations. European Journal of Organic Chemistry(22), pp. 4567-4581. (10.1002/ejoc.200400526)
- Khokhar, S. S. and Wirth, T. 2004. Selenocyclizations: control by coordination and by the counterion. Angewandte Chemie - International Edition 43(5), pp. 631-633. (10.1002/anie.200352884)
2002
- Jauslin, M. L., Wirth, T., Meier, T. and Schoumacher, F. 2002. A cellular model for Friedreich Ataxia reveals small-molecule glutathione peroxidase mimetics as novel treatment strategy. Human Molecular Genetics 11(24), pp. 3055-3063. (10.1093/hmg/11.24.3055)
- Schoumacher, F., Jauslin, M. L., Wirth, T. and Meier, T. 2002. A cellular model for Friedrich ataxia and its application in drug discovery. Neuromuscular Disorders 12(7-8), pp. 774-774.
- Uehlin, L., Fragale, G. and Wirth, T. 2002. New and Efficient Chiral Selenium Electrophiles. Chemistry - A European Journal 8(5), pp. 1125-1133. (10.1002/1521-3765(20020301)8:5<1125::AID-CHEM1125>3.0.CO;2-I)
2001
- Uehlin, L. and Wirth, T. 2001. Novel polymer-bound chiral selenium electrophiles. Organic Letters 3(18), pp. 2931-2933. (10.1021/ol0164435)
- Burpee, S. J., French, A. N., Haas, J. and Wirth, T. 2001. Progress in a computational investigation of conformers of chiral hypervalent iodine compounds. Abstracts of Papers of the American Chemical Society 221, pp. U170-U171.
- Uehlin, L. and Wirth, T. 2001. Chiral selenium electrophiles on solid-support. Chimia 55(1-2), pp. 65-67.
- Wirth, T. 2001. IBX - New reactions with an old reagent. Angewandte Chemie - International Edition 40(15), pp. 2812-2814. (10.1002/1521-3773(20010803)40:15<2812::AID-ANIE2812>3.0.CO;2-X)
- Uehlin, L. and Wirth, T. 2001. Mixed acetals as new precursors for selenium electrophiles. Phosphorus, Sulfur and Silicon and the Related Elements 171(1), pp. 189-194. (10.1080/10426500108046650)
2000
- Spichty, M., Fragale, G. and Wirth, T. 2000. Theoretical investigations on the stereoselective selenenylation reaction of alkenes. Journal of the American Chemical Society 122(44), pp. 10914-10916. (10.1021/ja001602l)
- Wirth, T. 2000. Organoselenium chemistry in stereoselective reactions. Angewandte Chemie - International Edition 39(21), pp. 3740-3749. (10.1002/1521-3773(20001103)39:21<3740::AID-ANIE3740>3.0.CO;2-N)
Articles
- Patra, T., Arepally, S., Seitz, J. and Wirth, T. 2024. Electrocatalytic continuous flow chlorinations with iodine(I/III) mediators. Nature Communications 15(1), article number: 6329. (10.1038/s41467-024-50643-z)
- Pramanik, M., Das, S., Babaahmadi, R., Pahar, S., Wirth, T., Richards, E. and Melen, R. L. 2024. B(C6F5)3-catalyzed selective C-H chalcogenation of arenes and heteroarenes. Chem (10.1016/j.chempr.2024.05.025)
- Edwards, L., Kariuki, B. M., Didsbury, M., Jones, C. D. and Wirth, T. 2024. Deville rebooted – practical N 2 O 5 synthesis †. Chemical Communications 60(46), pp. 5920-5923. (10.1039/d4cc01403k)
- Alzaidi, O. and Wirth, T. 2024. Continuous flow electroselenocyclization of allylamides and Unsaturated Oximes to selenofunctionalized oxazolines and isoxazolines. ACS Organic & Inorganic Au 4(3), pp. 350-355. (10.1021/acsorginorgau.4c00008)
- Pahar, S., van Ingen, Y., Babaahmadi, R., Kariuki, B. M., Wirth, T., Richards, E. and Melen, R. L. 2024. Diverse reactivity of amidinate-supported boron centers with the hypersilyl anion and access to a monomeric secondary boron hydride. Inorganic Chemistry 63(18), pp. 8302–8311. (10.1021/acs.inorgchem.4c00612)
- Ali, R., Wolfe, C. S. and Wirth, T. 2024. Non‐conventional methodologies for the synthesis of N‐Nntrosamines. Chemistry ‐ Methods 4(4), article number: e202300053. (10.1002/cmtd.202300053)
- Mizar, P., Arepally, S. and Wirth, T. 2024. Biphasic organic synthesis with continuous electro-flow. Current Opinion in Green and Sustainable Chemistry 46, article number: 100896. (10.1016/j.cogsc.2024.100896)
- Alotaibi, N. et al. 2024. B(C6F5)3-catalysed alkylation of imidazo[1,2-a]pyridines using α,β-unsaturated ketones. European Journal of Organic Chemistry 27(12), article number: e202400022. (10.1002/ejoc.202400022)
- Guerzoni, M. G., van Ingen, Y., Babaahmadi, R., Wirth, T., Richards, E. and Melen, R. L. 2024. An un-forgotten classic: the nitro-Mannich reaction between nitrones and silyl nitronates catalysed by B(C6F5)3 †. Chemical Science 15(7) (10.1039/d3sc05672d)
- Khan, M. N., van Ingen, Y., Boruah, T., McLauchlan, A., Wirth, T. and Melen, R. L. 2023. Advances in CO2 activation by frustrated Lewis pairs: from stoichiometric to catalytic reactions. Chemical Science 14(47), pp. 13661-13695. (10.1039/d3sc03907b)
- Ali, R., Patra, T. and Wirth, T. 2023. Alkene reactions with superoxide radical anions in flow electrochemistry. Faraday Discussions 247, pp. 297-301. (10.1039/D3FD00050H)
- Avanthay, M. et al. 2023. New strategies in organic electrosynthesis: General discussion. Faraday Discussions 247, pp. 125-131. (10.1039/D3FD90039H)
- Alkayal, A. et al. 2023. Flow cells and reactor design: General discussion. Faraday Discussions 247, pp. 333-341. (10.1039/D3FD90042H)
- Gutiérrez López, M. ?., Ali, R., Tan, M., Sakai, N., Wirth, T. and Matile, S. 2023. Electric field–assisted anion-π catalysis on carbon nanotubes in electrochemical microfluidic devices. Science Advances 9(41), article number: eadj5502. (10.1126/sciadv.adj5502)
- Boruah, T., Melen, R. L. and Wirth, T. 2023. Isodesmic metathesis chemistry: A novel way to recycle P(V). Chem Catalysis 3(8), article number: 100731. (10.1016/j.checat.2023.100731)
- Winterson, B., Bhattacherjee, D. and Wirth, T. 2023. Hypervalent halogen compounds in electrochemical reactions: advantages and prospects. Advanced Synthesis & Catalysis 365(16), pp. 2676-2689. (10.1002/adsc.202300412)
- Alkahtani, R. and Wirth, T. 2023. Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones. ACS Organic & Inorganic Au 3(4), pp. 209-216. (10.1021/acsorginorgau.3c00012)
- Ali, R., Babaahmadi, R., Didsbury, M., Stephens, R., Melen, R. L. and Wirth, T. 2023. Flow electrochemistry for the N‐Nitrosation of secondary amines. Chemistry - A European Journal 29(32), article number: e202300957. (10.1002/chem.202300957)
- Wirth, T. 2023. Hypervalent iodine in electrochemical reactions: advantages and prospects. SIS Letters(24)
- Alotaibi, N. et al. 2023. B(3,4,5-F3H2C6)3 Lewis acid-catalysed C3-allylation of indoles. Dalton Transactions 52(16) (10.1039/d3dt00745f)
- Spils, J., Wirth, T. and Nachtsheim, B. J. 2023. Two-step continuous-flow synthesis of 6-membered cyclic iodonium salts via anodic oxidation. Beilstein Journal of Organic Chemistry 19, pp. 27-32. (10.3762/bjoc.19.2)
- Patra, T. and Wirth, T. 2022. Oxidative cleavage of alkenes by photosensitized nitroarenes. Angewandte Chemie International Edition 61(47), article number: e202213772. (10.1002/anie.202213772)
- Singh, F. V., Shetgaonkar, S. E., Krishnan, M. and Wirth, T. 2022. Progress in organocatalysis with hypervalent iodine catalysts. Chemical Society Reviews 51(18), pp. 8102-8139. (10.1039/D2CS00206J)
- Khan, N., Itaya, K. and Wirth, T. 2022. Chiral iodotriptycenes: synthesis and catalytic applications. ChemistryOpen 11(8), article number: e202200158. (10.1002/open.202200158)
- Khan, N., Itaya, K. and Wirth, T. 2022. Chiral iodotriptycenes: Synthesis and catalytic applications. ChemistryOpen 11(7), article number: e202200145. (10.1002/open.202200145)
- Hareram, M. D. et al. 2022. Electrochemical deconstructive functionalization of cycloalkanols via alkoxy radicals enabled by proton-coupled Electron transfer. Organic Letters 24(21), pp. 3890-3895. (10.1021/acs.orglett.2c01552)
- Kaehler, T. et al. 2022. Borane promoted aryl transfer reaction for the synthesis of α-aryl functionalised β-hydroxy and β-keto esters. Organic and Biomolecular Chemistry 20(21), pp. 4298-4302. (10.1039/D2OB00643J)
- Xiong, Z., Weidlich, F., Sanchez, C. and Wirth, T. 2022. Biomimetic total synthesis of (−)-galanthamine via intramolecular anodic aryl–phenol coupling. Organic and Biomolecular Chemistry 20(20), pp. 4123-4127. (10.1039/D2OB00669C)
- Soldatova, N. S. et al. 2022. Zwitterionic iodonium species afford halogen bond-based porous organic frameworks. Chemical Science 13(19), pp. 5650-5658. (10.1039/D2SC00892K)
- Zhang, H. and Wirth, T. 2022. Oxidation of BINOLs by hypervalent iodine reagents: facile synthesis of xanthenes and lactones. Chemistry - A European Journal 28(21) (10.1002/chem.202200181)
- Wirth, T., Patra, T. and Winterson, B. 2022. Hypervalent bromine(III) compounds: synthesis, applications, prospects. Synthesis: Journal of Synthetic Organic Chemistry 54(5), pp. 1261-1271. (10.1055/a-1675-8404)
- Zhang, H., Cormanich, R. A. and Wirth, T. 2022. Chiral ligands in hypervalent iodine compounds: synthesis and structures of binaphthyl-based λ3-iodanes. Chemistry - A European Journal 28(5), article number: e202103623. (10.1002/chem.202103623)
- Amri, N. and Wirth, T. 2021. Flow electrosynthesis of sulfoxides, sulfones, and sulfoximines without supporting electrolytes. Journal of Organic Chemistry 86(22), pp. 15961-15972. (10.1021/acs.joc.1c00860)
- Amri, N. and Wirth, T. 2021. Recent advances in the electrochemical synthesis of organosulfur compounds. Chemical Record 21(9), pp. 2526-2537. (10.1002/tcr.202100064)
- Wirth, T. 2021. Iodine(III) mediators in electrochemical batch and flow reactions. Current Opinion in Electrochemistry 28, article number: 100701. (10.1016/j.coelec.2021.100701)
- Seitz, J. and Wirth, T. 2021. Electrochemical bromofunctionalization of alkenes in a flow reactor. Organic and Biomolecular Chemistry 19(31), pp. 6892-6896. (10.1039/D1OB01302E)
- Winterson, B., Rennigholtz, T. and Wirth, T. 2021. Flow electrochemistry: a safe tool for fluorine chemistry. Chemical Science 12(26), pp. 9053-9059. (10.1039/D1SC02123K)
- Dasgupta, A., Thiehoff, C., Newman, P. D., Wirth, T. and Melen, R. L. 2021. Reactions promoted by hypervalent iodine reagents and boron Lewis acids. Organic and Biomolecular Chemistry 19(22), pp. 4852-4865. (10.1039/D1OB00740H)
- Khan, M. N. and Wirth, T. 2021. Chiral Triptycenes: concepts, progress and prospects. Chemistry - A European Journal 27(24), pp. 7059-7068. (10.1002/chem.202005317)
- Alharbi, H., Elsherbini, M., Qurban, J. and Wirth, T. 2021. C−N axial chiral hypervalent iodine reagents: catalytic stereoselective α‐oxytosylation of ketones. Chemistry - A European Journal 27(13), pp. 4317-4321. (10.1002/chem.202005253)
- Yamamoto Raynbird, M., Khokhar, S., Neef, D., Evans, G. and Wirth, T. 2021. Synthesis of ajoene analogues by novel synthetic strategies. Chemistry - A European Journal 27(9), pp. 3008-3012. (10.1002/chem.202005023)
- Wirth, T. and Zhang, H. 2021. Recent advances in asymmetric functionalization of olefins induced by chiral hypervalent iodine reagents. Chinese Journal of Organic Chemistry 41(1), pp. 65-70. (10.6023/cjoc202006013)
- Elsherbini, M., Osi, A., Alharbi, H., Karam, F. and Wirth, T. 2021. Sulfur-based chiral iodoarenes: an underexplored class of chiral hypervalent iodine reagents. Synthesis: Journal of Synthetic Organic Chemistry 55, pp. 307-314. (10.1055/a-1508-9593)
- Singh, F. V. and Wirth, T. 2021. Hypervalent iodine chemistry and light: photochemical reactions involving hypervalent iodine Chemistry. ARKIVOC 2021(7), pp. 12-47. (10.24820/ark.5550190.p011.483)
- Wirth, T. and Amri, N. 2020. Accelerating electrochemical synthesis through automated flow: efficient synthesis of chalcogenophosphites. SYNLETT 31(19), pp. 1894-1898. (10.1055/s-0040-1707141)
- Hardwick, T., Cicala, R., Wirth, T. and Ahmed, N. 2020. Memory of chirality in a room temperature flow electrochemical reactor. Scientific Reports 10(1), article number: 16627. (10.1038/s41598-020-73957-6)
- Huynh, F., Tailby, M., Finniear, A., Stephens, K., Allemann, R. K. and Wirth, T. 2020. Accelerating biphasic biocatalysis through new process windows. Angewandte Chemie International Edition 59(38), pp. 16490-16495. (10.1002/anie.202005183)
- Elsherbini, M., Huynh, F., Dunbabin, A., Allemann, R. and Wirth, T. 2020. Selective hydroboration - oxidation of terminal alkenes under flow conditions. Chemistry - A European Journal 26(50), pp. 11423-11425. (10.1002/chem.202001650)
- Wirth, T. and Hokamp, T. 2020. Hypervalent iodine(III)‐catalysed enantioselective α‐acetoxylation of ketones. Chemistry - A European Journal 26(46), pp. 10417-10421. (10.1002/chem.202000927)
- Raynbird, M. Y., Silva, F., Smallman, H., Khokhar, S. S., Neef, D., Evans, G. J. S. and Wirth, T. 2020. Short total synthesis of ajoene, (E ,Z )‐4,5,9‐Trithiadodeca‐1,6,11‐triene 9‐oxide, in batch and (E ,Z )‐4,5,9‐Trithiadodeca‐1,7,11‐triene in continuous flow. Chemistry - A European Journal 26(38), pp. 8363-8367. (10.1002/chem.202001598)
- Valikhani, D., Srivastava, P. L., Allemann, R. K. and Wirth, T. 2020. Immobilised enzymes for sesquiterpene synthesis in batch and flow systems. ChemCatChem 12(8), pp. 2194-22197. (10.1002/cctc.201902135)
- Gazis, T. et al. 2020. 1,3-Carboboration of iodonium ylides. Chemical Communications 56, pp. 3345-3348. (10.1039/C9CC08749D)
- Amri, N. and Wirth, T. 2020. Automated electrochemical selenenylations. Synthesis 52(12), pp. 1751-1761. (10.1055/s-0039-1690868)
- Santi, M., Seitz, J., Cicala, R., Hardwick, T., Ahmed, N. and Wirth, T. 2019. Memory of chirality in flow electrochemistry: fast optimisation with DoE and online 2D-HPLC. Chemistry - A European Journal 25(71), pp. 16230-16235. (10.1002/chem.201904711)
- Elsherbini, M. and Wirth, T. 2019. Electroorganic synthesis under flow conditions. Accounts of Chemical Research 52(12), pp. 3287-3296. (10.1021/acs.accounts.9b00497)
- Allen, B. D. W., Mishra, D., Seastram, A. C., McBride, T., Wirth, T., Browne, D. L. and Morrill, L. C. 2019. Manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols via alkoxy radicals. Organic Letters 21(22), pp. 9241-9246. (10.1021/acs.orglett.9b03652)
- Elsherbini, M., Allemann, R. K. and Wirth, T. 2019. 'Dark' singlet oxygen made easy. Chemistry - A European Journal 25(54), pp. 12486-12490. (10.1002/chem.201903505)
- Gazis, T. A., Dasgupta, A., Hill, M. S., Rawson, J. M., Wirth, T. and Melen, R. L. 2019. Reactions of hydrazones and hydrazides with Lewis acidic boranes. Dalton Transactions(33), pp. 12391-12395. (10.1039/C9DT01359H)
- Elsherbini, M., Winterson, B., Alharbi, H., Folgueiras Amador, A. A., Genot, C. and Wirth, T. 2019. Continuous electrochemical generator of hypervalent iodine reagents: synthetic applications in flow. Angewandte Chemie International Edition 58(29), pp. 9811-9815. (10.1002/anie.201904379)
- Qurban, J., Elsherbini, M., Alharbi, H. and Wirth, T. 2019. Synthesis, characterisation, and reactivity of novel pseudocyclic hypervalent iodine reagents with heteroaryl carbonyl substituents. Chemical Communications 55, pp. 7998-8000. (10.1039/C9CC03905H)
- Yusubov, M. S. et al. 2019. 2-Iodoxybenzoic acid ditriflate: the most powerful hypervalent iodine(v) oxidant. Chemical Communications 55, pp. 7760-7763. (10.1039/C9CC04203B)
- Hokamp, T. and Wirth, T. 2019. Structurally defined α-Tetralol-Based chiral hypervalent iodine reagents. Journal of Organic Chemistry 84(13), pp. 8674-8682. (10.1021/acs.joc.9b01315)
- Santi, M., Ould, D. M. C., Wenz, J., Soltani, Y., Melen, R. L. and Wirth, T. 2019. Metal-free tandem rearrangement/lactonization: Access to 3,3-disubstituted benzofuran-2-(3H)-ones. Angewandte Chemie International Edition 58(23), pp. 7861-7865. (10.1002/anie.201902985)
- Wirth, T. and Knight, D. 2019. Morpholin-2-one derivatives via intramolecular acid-catalyzed hydroamination. SYNTHESIS 51(7), pp. 1643-1648. (10.1055/s-0037-1610674)
- Amri, N., Skilton, R., Guthrie, D. and Wirth, T. 2019. Efficient flow electrochemical alkoxylation of N-formylpyrrolidine. SYNLETT 30(10), pp. 1183-1186. (10.1055/s-0037-1611774)
- Soldatova, N. S., Postnikov, P. S., Yusubov, M. S. and Wirth, T. 2019. Flow synthesis of iodonium trifluoroacetates through direct oxidation of iodoarenes by Oxone®. European Journal of Organic Chemistry 2019(10), pp. 2081-2088. (10.1002/ejoc.201900220)
- Singh, F. V. and Wirth, T. 2019. Selenium reagents as catalysts. Catalysis Science & Technology 9(5), pp. 1073-1091. (10.1039/C8CY02274G)
- Islam, M., Kariuki, B. M., Shafiq, Z., Wirth, T. and Ahmed, N. 2018. Efficient electrosynthesis of thiazolidin-2-imines via oxysulfurization of thiourea-tethered terminal alkenes using the flow microreactor. European Journal of Organic Chemistry (10.1002/ejoc.201801688)
- Wirth, T., Gao, W., Xiong, Z. and Pirhaghani, S. 2018. Enantioselective electrochemical lactonization using chiral iodoarenes as mediators. Synthesis (Stuttgart) (10.1055/s-0037-1610373)
- Silva, F., Khokhar, S. S., Williams, D. M., Saunders, R., Evans, G. J. S., Graz, M. and Wirth, T. 2018. Short total synthesis of ajoene. Angewandte Chemie International Edition 57(38), pp. 12290-12293. (10.1002/anie.201808605)
- Elsherbini, M. and Wirth, T. 2018. Hypervalent iodine reagents by anodic oxidation: a powerful green synthesis. Chemistry - a European Journal 24(51), pp. 13399-13407. (10.1002/chem.201801232)
- Mironova, I. A. et al. 2018. Preparation and X-ray structure of 2-iodoxybenzenesulfonic acid (IBS) - a powerful hypervalent iodine(V) oxidant. Beilstein Journal of Organic Chemistry 14, pp. 1854-1858. (10.3762/bjoc.14.159)
- Hokamp, T., Mollari, L., Wilkins, L. C., Melen, R. L. and Wirth, T. 2018. Alternative strategies with iodine: fast access to previously inaccessible iodine(III) compounds. Angewandte Chemie International Edition 57(27), pp. 8306-8309. (10.1002/anie.201804642)
- Elsherbini, M. and Wirth, T. 2018. Mechanochemical synthesis of N-tert-butanesulfinyl imines under metal-free conditions. Tetrahedron 74(25), pp. 3101-3106. (10.1016/j.tet.2017.11.028)
- Silva, F. et al. 2018. Selective oxidation of sulfides in flow chemistry. European Journal of Organic Chemistry 2018(18), pp. 2134-2137. (10.1002/ejoc.201800339)
- Soldatova, N., Postnikov, P., Kukurina, O., Zhdankin, V. V., Yoshimura, A., Wirth, T. and Yusubov, M. S. 2018. One-pot synthesis of diaryliodonium salts from arenes and aryl iodides with Oxone-sulfuric acid. Beilstein Journal of Organic Chemistry 14, pp. 849-855. (10.3762/bjoc.14.70)
- Yusubov, M. et al. 2018. Reactions of 1-arylbenziodoxolones with azide anion: Experimental and computational study of substituent effects. European Journal of Organic Chemistry 2018(5), pp. 640-647. (10.1002/ejoc.201701595)
- Folgueiras-Amador, A. A., Qian, X., Xu, H. and Wirth, T. 2018. Catalyst- and supporting electrolyte-free electrosynthesis of benzothiazoles and thiazolopyridines in continuousf flow. Chemistry - A European Journal 24(2), pp. 487-491. (10.1002/chem.201705016)
- Wirth, T., Hokamp, T., Storm, A. and Yusubov, M. 2018. Iodine monoacetate for efficient oxyiodinations of alkenes and alkynes. Synlett 29(4), pp. 415-418. (10.1055/s-0036-1589119)
- Wirth, T. 2017. Integration of flow chemistry in multistep syntheses. European Journal of Organic Chemistry 2017(44), pp. 6464. (10.1002/ejoc.201701543)
- Folgueiras-Amador, A. A., Philipps, K., Guilbaud, S., Poelakker, J. and Wirth, T. 2017. An easy-to-machine electrochemical flow microreactor: efficient synthesis of isoindolinone and flow functionalization. Angewandte Chemie International Edition 56(48), pp. 15446-15450. (10.1002/anie.201709717)
- Wirth, T. 2017. Thomas Wirth. European Journal of Organic Chemistry 2017(44), pp. 6465-6464. (10.1002/ejoc.201701545)
- Wirth, T. 2017. Organic synthesis in flow for medicinal chemistry. Bioorganic & Medicinal Chemistry 25(23), pp. 6179. (10.1016/j.bmc.2017.11.013)
- Aldmairi, A. H., Knight, D. and Wirth, T. 2017. Acid-catalyzed tandem process for the one-pot synthesis of oxazolidines. Synlett 28(20), pp. 2976-2978. (10.1055/s-0036-1591513)
- Qurban, J., Elsherbini, M. and Wirth, T. 2017. Electron-deficient chiral lactic acid-based hypervalent iodine reagents. Journal of Organic Chemistry 82(22), pp. 11872-11876. (10.1021/acs.joc.7b01571)
- Folgueiras-Amador, A. and Wirth, T. 2017. Perspectives in flow electrochemistry. Journal of Flow Chemistry 7(3-4), pp. 94-95. (10.1556/1846.2017.00020)
- Santi, M., Müller, S. T. R., Folgueiras-Amador, A., Uttry, A., Hellier, P. and Wirth, T. 2017. Enantioselective synthesis of trans-2,3-Dihydro-1H-indoles through C-H Insertion of a-Diazocarbonyl compounds. European Journal of Organic Chemistry 2017(14), pp. 1889-1893. (10.1002/ejoc.201700412)
- Tang, X., Demiray, M., Wirth, T. and Allemann, R. K. 2017. Concise synthesis of artemisinin from a farnesyl diphosphate analogue. Bioorganic & Medicinal Chemistry 26(7), pp. 1314-1319. (10.1016/j.bmc.2017.03.068)
- Demiray, M., Tang, X., Wirth, T., Faraldos, J. A. and Allemann, R. K. 2017. An efficient chemoenzymatic synthesis of dihydroartemisinic aldehyde. Angewandte Chemie International Edition 56(15), pp. 4347-4350. (10.1002/anie.201609557)
- Demiray, M., Tang, X., Wirth, T., Faraldos, J. A. and Allemann, R. K. 2017. Effiziente chemoenzymatische Synthese von dhydroartemisinaldehyd. Angewandte Chemie 129(15), pp. 4411-4415. (10.1002/ange.201609557)
- Wirth, T. 2017. Novel organic synthesis through ultrafast chemistry. Angewandte Chemie - International Edition 56(3), pp. 682-684. (10.1002/anie.201609595)
- Wirth, T. 2017. Neue organische synthesen durch ultraschnelle chemie. Angewandte Chemie 129(3), pp. 698-700. (10.1002/ange.201609595)
- Tang, X., Allemann, R. K. and Wirth, T. 2017. Optimising terpene synthesis with flow biocatalysis. European Journal of Organic Chemistry 2017(2), pp. 414-418. (10.1002/ejoc.201601388)
- Malmedy, F. and Wirth, T. 2017. Cyclization of malonate derivatives with iodine(III) reagents. European Journal of Organic Chemistry (10.1002/ejoc.201601587)
- Wirth, T. and Mizar, P. 2017. Iodoaminations of alkenes. Synthesis 49(5), pp. 981-986. (10.1055/s-0036-1588630)
- Soldatova, N., Postnikov, P., Kukurina, O., Zhdankin, V. V., Yoshimura, A., Wirth, T. and Yusubov, M. S. 2016. Facile one-pot synthesis of diaryliodonium salts from arenes and aryl iodides with oxone. ChemistryOpen (10.1002/open.201600129)
- Hutchings, M. and Wirth, T. 2016. Safe use of nitromethane for aldol reactions in flow. Journal of Flow Chemistry 6(3), pp. 202-205. (10.1556/1846.2016.00022)
- Malmedy, F. and Wirth, T. 2016. Stereoselective ketone rearrangements with hypervalent iodine reagents. Chemistry - a European Journal 22(45) (10.1002/chem.201603022)
- Malmedy, F. and Wirth, T. 2016. Frontispiece: stereoselective ketone rearrangements with hypervalent iodine reagents. Chemistry - a European Journal 22(45), pp. 16072-16077. (10.1002/chem.201684562)
- Wilkins, L. C., Gunther, B. A. R., Walther, M., Lawson, J. R., Wirth, T. and Melen, R. L. 2016. Contrasting frustrated Lewis pair reactivity with selenium- and boron-based Lewis acids. Angewandte Chemie International Edition 55(37), pp. 11292-11295. (10.1002/anie.201605239)
- Wilkins, L., Günther, B. A., Walther, M., Lawson, J., Wirth, T. and Melen, R. 2016. Gegensätzliche Reaktivität frustrierter Lewis-Paare mit Selen- und Bor-basierten Lewis-Säuren. Angewandte Chemie 128(37), pp. 11462-11465. (10.1002/ange.201605239)
- Müller, S. T. R., Hokamp, T., Ehrmann, S., Hellier, P. and Wirth, T. 2016. Ethyl lithiodiazoacetate: extremely unstable intermediate handled efficiently in flow. Chemistry: A European Journal 22(34), pp. 11940-11942. (10.1002/chem.201602133)
- Wirth, T. and Hutchings, M. 2016. A simple setup for transfer hydrogenations in flow chemistry. Synlett 27(12), pp. 1832-1835. (10.1055/s-0035-1561624)
- Brown, M., Kumar, R., Rehbein, J. and Wirth, T. 2016. Enantioselective oxidative rearrangements with chiral hypervalent iodine reagents. Chemistry - a European Journal 22(12), pp. 4030-4035. (10.1002/chem.201504844)
- Mueller, S. T. R., Murat, A., Hellier, P. and Wirth, T. 2016. Toward a large-scale approach to milnacipran analogues using diazo compounds in flow chemistry. Organic Process Research and Development 20(2), pp. 495-502. (10.1021/acs.oprd.5b00308)
- Mizar, P., Niebuhr, R., Hutchings, M., Farooq, U. and Wirth, T. 2016. Thioamination of alkenes with hypervalent iodine reagents. Chemistry - a European Journal 22(5), pp. 1614-1617. (10.1002/chem.201504636)
- Edwards, R., de Vries, W., Westwell, A. D., Daniels, S. and Wirth, T. 2015. Solid-supported iodonium salts for fluorinations. European Journal of Organic Chemistry 2015(31), pp. 6909-6916. (10.1002/ejoc.201500992)
- Muller, S. T. R., Murat, A., Hellier, P. and Wirth, T. 2015. Safe handling of diazo reagents through inline analytics and flow chemistry. Chimica Oggi 33(5), pp. 74-77.
- Wirth, T. 2015. Kleine Organoselenverbindungen: mehr als nur Mimetika der Glutathion-Peroxidase. Angewandte Chemie 127(35), pp. 10212-10214. (10.1002/ange.201505056)
- Wirth, T. 2015. Small organoselenium compounds: more than just glutathione peroxidase mimics. Angewandte Chemie - International Edition 54(35), pp. 10074-10076. (10.1002/anie.201505056)
- Baker, A., Graz, M., Saunders, R., Evans, G. J. S., Pitotti, I. and Wirth, T. 2015. Flow alkylation of thiols, phenols, and amines using a heterogenous base in a packed-bed reactor. Journal of Flow Chemistry 5(2), pp. 65. (10.1556/1846.2015.00009)
- Tancock, J. and Wirth, T. 2015. Selenium-mediated synthesis of tetrasubstituted naphthalenes through rearrangement. Molecules 20(6), pp. 10866-10872. (10.3390/molecules200610866)
- Kumar, R. and Wirth, T. 2015. Asymmetric synthesis with hypervalent iodine reagents. Topics in Current Chemistry, pp. 1-19. (10.1007/128_2015_639)
- Edwards, R. and Wirth, T. 2015. [18F]6-fluoro-3,4-dihydroxy-l-phenylalanine - recent modern syntheses for an elusive radiotracer. Journal of Labelled Compounds and Radiopharmaceuticals 58(5), pp. 183-187. (10.1002/jlcr.3285)
- Muller, S. T. R., Murat, A., Maillos, D., Lesimple, P., Hellier, P. and Wirth, T. 2015. Rapid generation and safe use of carbenes enabled by a novel flow protocol with in-line IR spectroscopy. Chemistry - A European Journal 21(19), pp. 7016-7020. (10.1002/chem.201500416)
- Müller, S. T. R. and Wirth, T. 2015. Diazo compounds in continuous-flow technology. Chemsuschem 8(2), pp. 245-250. (10.1002/cssc.201402874)
- Edwards, R., Westwell, A. D., Daniels, S. and Wirth, T. 2015. Convenient synthesis of diaryliodonium salts for the production of [18F]F-DOPA. European Journal of Organic Chemistry 2015(3), pp. 625-630. (10.1002/ejoc.201403378)
- Wirth, T., Brown, M., Delorme, M., Malmedy, F., Malmgren, J. and Olofsson, B. 2015. Synthesis of new chiral diaryliodonium salts. Synlett 26(11), pp. 1573-1577. (10.1055/s-0034-1380687)
- Attah Egu, S., Okoro, U. and Wirth, T. 2014. Synthesis of quinolinequinone derivatives and related carbocyclic compounds. ScienceOpen Research (10.14293/S2199-1006.1.SOR-CHEM.AALL9P.v1)
- Ambreen, N. and Wirth, T. 2014. High-temperature synthesis of amides from alcohols or aldehydes by using flow chemistry. European Journal of Organic Chemistry 2014(34), pp. 7590-7593. (10.1002/ejoc.201403280)
- Elsherbini, M. S., Hamama, W. S., Zoorob, H. H., Bhowmick, D., Mugesh, G. and Wirth, T. 2014. Synthesis and antioxidant activities of novel chiral ebselen analogues. Heteroatom Chemistry 25(5), pp. 320-325. (10.1002/hc.21164)
- Mizar, P., Burrelli, A., Gunther, E., Softje, M., Farooq, U. and Wirth, T. 2014. Organocatalytic stereoselective iodoamination of alkenes. Chemistry - a European Journal 20(41), pp. 13113-13116. (10.1002/chem.201404762)
- Mizar, P., Laverny, A., El-Sherbini, M., Farid, U., Brown, M., Malmedy, F. and Wirth, T. 2014. Enantioselective diamination with novel chiral hypervalent iodine catalysts. Chemistry - A European Journal 20(32), pp. 9910-9913. (10.1002/chem.201403891)
- Arai, K. and Wirth, T. 2014. Rapid electrochemical deprotection of the isonicotinyloxycarbonyl group from carbonates and thiocarbonates in a microfluidic reactor. Organic Process Research and Development, article number: 140708073813000. (10.1021/op500155f)
- Mizar, P. and Wirth, T. 2014. Flexible stereoselective functionalizations of ketones through umpolung with hypervalent iodine reagents. Angewandte Chemie International Edition 53(23), pp. 5993-5997. (10.1002/anie.201400405)
- Mizar, P. and Wirth, T. 2014. Flexible stereoselektive Funktionalisierung von Ketonen durch Umpolung mit hypervalenten Iodreagentien. Angewandte Chemie 126(23), pp. 6103-6107. (10.1002/ange.201400405)
- Muller, S. T. R., Smith, D., Hellier, P. and Wirth, T. 2014. Safe generation and direct use of diazoesters in flow chemistry. Synlett 25(6), pp. 871-875. (10.1055/s-0033-1340835)
- Arai, K., Watts, K. and Wirth, T. 2014. Difluoro- and trifluoromethylation of electron-deficient alkenes in an electrochemical microreactor. ChemistryOpen 3(1), pp. 23-28. (10.1002/open.201300039)
- Watts, K., Baker, A. R. and Wirth, T. 2014. Electrochemical synthesis in microreactors. Journal of Flow Chemistry 4(1), pp. 2-11. (10.1556/JFC-D-13-00030)
- Singh, F. V. and Wirth, T. 2014. 7.29 oxidative functionalization with hypervalent halides. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 7, pp. 880-933. (10.1016/B978-0-08-097742-3.00735-7)
- Singh, F. V. and Wirth, T. 2014. Hypervalent iodine-catalyzed oxidative functionalizations including stereoselective reactions. Chemistry - An Asian Journal 9(4), pp. 950-971. (10.1002/asia.201301582)
- Baker, A. R., Graz, M., Saunders, R., Evans, G. J. S., Kaul, S. and Wirth, T. 2013. Flow synthesis of symmetrical di- and trisulfides using phase-transfer catalysis. Journal of Flow Chemistry 3(4), pp. 118-121. (10.1556/JFC-D-13-00013)
- Cascón, O., Richter, G., Allemann, R. K. and Wirth, T. 2013. Efficient terpene synthase catalysis by extraction in flow. ChemPlusChem 78(11), pp. 1334-1337. (10.1002/cplu.201300303)
- Singh, F. V. and Wirth, T. 2013. Oxidative rearrangements with hypervalent iodine reagents. Synthesis (Stuttgart) 45(18), pp. 2499-2511. (10.1055/s-0033-1339679)
- Farid, U., Malmedy, F., Claveau, R., Albers, L. and Wirth, T. 2013. Stereoselective rearrangements with chiral hypervalent iodine reagents. Angewandte Chemie - International Edition 52(27), pp. 7018-7022. (10.1002/anie.201302358)
- König, B., Kreitmeier, P., Hilgers, P. and Wirth, T. 2013. Flow chemistry in undergraduate organic chemistry education. Journal of Chemical Education 90(7), pp. 934-936. (10.1021/ed3006083)
- Brown, M., Farid, U. and Wirth, T. 2013. Hypervalent iodine reagents as powerful electrophiles. Synlett 24(4), pp. 424-431. (10.1055/s-0032-1318103)
- Farid, U., Malmedy, F., Claveau, R., Albers, L. and Wirth, T. 2013. Stereoselektive Umlagerungen mit chiralen hypervalenten Iodreagentien. Angewandte Chemie 125(27), pp. 7156-7160. (10.1002/ange.201302358)
- Ambreen, N., Kumar, R. and Wirth, T. 2013. Hypervalent iodine/TEMPO-mediated oxidation in flow systems: a fast and efficient protocol for alcohol oxidation. Beilstein Journal of Organic Chemistry 9, pp. 1437-1442. (10.3762/bjoc.9.162)
- Singh, F. V., Rehbein, J. and Wirth, T. 2012. Facile oxidative rearrangements using hypervalent iodine reagents. ChemistryOpen 1(6), pp. 245-250. (10.1002/open.201200037)
- Gabriele, E., Singh, F. V., Freudendahl, D. M. and Wirth, T. 2012. Selenenylations of alkenes with styrene nucleophiles. Tetrahedron 68(51), pp. 10573-10576. (10.1016/j.tet.2012.08.034)
- Santi, C., Di Lorenzo, R., Tidei, C., Bagnoli, L. and Wirth, T. 2012. Stereoselective selenium catalyzed dihydroxylation and hydroxymethoxylation of alkenes. Tetrahedron 68(51), pp. 10530-10535. (10.1016/j.tet.2012.08.078)
- Farid, U. and Wirth, T. 2012. 5,6,7,8-Tetrafluoro-1-hydroxy-1-oxobenziodoxol-3(1H)one (Tetrafluoro-IBX). e-EROS: Encyclopedia of Reagents for Organic Synthesis, article number: rn01489. (10.1002/047084289X.rn01489)
- Wirth, T. 2012. Flow chemistry: enabling technology in drug discovery and process research [Editorial]. ChemSusChem 5(2), pp. 215-216. (10.1002/cssc.201200061)
- Singh, F. V. and Wirth, T. 2012. Hypervalent iodine mediated oxidative cyclization of o-hydroxystilbenes into benzo- and naphthofurans. Synthesis (Stuttgart) 44(8), pp. 1171-1177. (10.1055/s-0031-1290588)
- Martínez-Máñez, R. and Wirth, T. 2012. Opening up the world of chemistry [Editorial]. ChemistryOpen 1(1), pp. 4. (10.1002/open.201100009)
- Audiger, L. E., Watts, K., Elmore, S. C., Robinson, R. I. and Wirth, T. 2012. Ritter reactions in flow. ChemSusChem 5(2), pp. 257-260. (10.1002/cssc.201100372)
- Zhao, L., Li, J., Li, Y., Liu, J., Wirth, T. and Li, Z. 2012. Selenium-containing naphthalimides as anticancer agents: Design, synthesis and bioactivity. Bioorganic and Medicinal Chemistry 20(8), pp. 2558-2563. (10.1016/j.bmc.2012.02.049)
- Farid, U. and Wirth, T. 2012. Highly stereoselective metal-free oxyaminations using chiral hypervalent iodine reagents. Angewandte Chemie. International Edition 51(14), pp. 3462-3465. (10.1002/anie.201107703)
- Farid, U. and Wirth, T. 2012. Innenrücktitelbild: stereoselektive metallfreie oxyaminierungen mit chiralen hypervalenten iodreagentien (Angew. Chem. 14/2012). Angewandte Chemie 124(14), pp. 3549. (10.1002/ange.201201230)
- Farid, U. and Wirth, T. 2012. Inside back cover: highly stereoselective metal-free oxyaminations using chiral hypervalent iodine reagents (Angew. Chem. Int. Ed. 14/2012). Angewandte Chemie - International Edition 51(14), pp. 3491. (10.1002/anie.201201230)
- Zhao, L., Li, Z. and Wirth, T. 2011. Asymmetric Methoxyselenenylations with Chiral Selenium Electrophiles. European Journal of Organic Chemistry 2011(35), pp. 7080-7082. (10.1002/ejoc.201101373)
- Watts, K., Gattrell, W. and Wirth, T. 2011. A practical microreactor for electrochemistry in flow. Beilstein Journal of Organic Chemistry 7, pp. 1108-1114. (10.3762/bjoc.7.127)
- Rasheed, M. and Wirth, T. 2011. Fast optimisation of a Diels-Alder reaction in a flow microreactor by in-line HPLC analysis. Chimica Oggi - Chemistry Today 29(3), pp. 53-55.
- Wirth, T. and Zanda, M. 2011. SYNTHESIS/SYNLETT Advisory Board Focus: Professor Thomas Wirth (Cardiff University, UK) [Interview]. Synthesis -Stuttgart-(5), pp. A26-A26. (10.1055/s-0030-1259586)
- Ahmed-Omer, B., Barrow, D. A. and Wirth, T. 2011. Multistep reactions using microreactor chemistry. Arkivoc Online Journal of Organic Chemistry(4), pp. 26-36.
- Zhao, L., Li, Z. and Wirth, T. 2011. Preparation of Novel Chiral Non-Racemic Diselenides and Applications in Asymmetric Synthesis. European Journal of Organic Chemistry(1), pp. 176-182. (10.1002/ejoc.201001272)
- Rasheed, M. and Wirth, T. 2011. Intelligent Microflow: Development of Self-Optimizing Reaction Systems. Angewandte Chemie - International Edition 50(2), pp. 357-358. (10.1002/anie.201006107)
- Wirth, T. 2011. Professor Siegfried Blechert: A Tribute. Arkivoc Online Journal of Organic Chemistry(4), pp. 1-5.
- Singh, F. V. and Wirth, T. 2011. Selenium-catalyzed regioselective cyclization of unsaturated carboxylic acids using hypervalent iodine oxidants. Organic Letters 13(24), pp. 6504-6507. (10.1021/ol202800k)
- Brandt, J. C., Elmore, S. C., Robinson, R. I. and Wirth, T. 2010. Safe and Efficient Ritter Reactions in Flow. Synlett(20), pp. 3099-3103. (10.1055/s-0030-1259075)
- Luk, Y., Allender, C. J. and Wirth, T. 2010. Molecular imprinted polymers binding low functionality templates. Tetrahedron Letters 51(45), pp. 5883-5885. (10.1016/j.tetlet.2010.08.108)
- Khan, Z. A., Iwaoka, M. and Wirth, T. 2010. Novel cyclization cascades to functionalized indanes and tetrahydronaphthalenes. Tetrahedron 66(33), pp. 6639-6646. (10.1016/j.tet.2010.03.062)
- Zhao, L. W., Li, Z. and Wirth, T. 2010. Triptycene Derivatives: Synthesis and Applications. Chemistry Letters 39(7), pp. 658-667.
- Freudendahl, D. M., Iwaoka, M. and Wirth, T. 2010. Synthesis of New Sulfoxide-Containing Diselenides and Unexpected Cyclization Reactions to 2,3-Dihydro-1,4-benzoselenothiine 1-Oxides. European Journal of Organic Chemistry(20), pp. 3934-3944. (10.1002/ejoc.201000514)
- Altermann, S., Schafer, S. and Wirth, T. 2010. New chiral hypervalent iodine(V) compounds as stoichiometric oxidants. Tetrahedron 66(31), pp. 5902-5907. (10.1016/j.tet.2010.05.079)
- Quideau, S. and Wirth, T. 2010. Hypervalent iodine chemistry-recent advances and applications [Preface]. Tetrahedron 66(31), pp. 5737-5738. (10.1016/j.tet.2010.06.026)
- Shahzad, S. A., Venin, C. and Wirth, T. 2010. Diselenide- and Disulfide-Mediated Synthesis of Isocoumarins. European Journal of Organic Chemistry(18), pp. 3465-3472. (10.1002/ejoc.201000308)
- Farooq, U., Schäfer, S., Shah, A., Freudendahl, D. M. and Wirth, T. 2010. Synthesis of new enantiomerically pure organoiodine catalysts and their application in the alpha-functionalization of ketones. Synthesis -Stuttgart-(6), pp. 1023-1029. (10.1055/s-0029-1218640)
- Shahzad, S. A., Vivant, C. and Wirth, T. 2010. Selenium-Mediated Synthesis of Biaryls through Rearrangement. Organic Letters 12(6), pp. 1364-1367. (10.1021/ol100274e)
- Schäfer, S. and Wirth, T. 2010. A versatile and highly reactive polyfluorinated hypervalent iodine(III) compound. Angewandte Chemie. International Edition 49(15), pp. 2786-2789. (10.1002/anie.200907134)
- Ahmed-Omer, B., Barrow, D. A. and Wirth, T. 2009. Heck reactions using segmented flow conditions. Tetrahedron Letters 50(26), pp. 3352-3355. (10.1016/j.tetlet.2009.02.133)
- Brandt, J. C. and Wirth, T. 2009. Controlling hazardous chemicals in microreactors: Synthesis with iodine azide. Beilstein Journal of Organic Chemistry 5(30) (10.3762/bjoc.5.30)
- Freudendahl, D. M., Shahzad, S. A. and Wirth, T. 2009. Recent Advances in Organoselenium Chemistry. European Journal of Organic Chemistry(11), pp. 1649-1664. (10.1002/ejoc.200801171)
- Khan, Z. A. and Wirth, T. 2009. Synthesis of Indene Derivatives via Electrophilic Cyclization. Organic Letters 11(1), pp. 229-231. (10.1021/ol8024956)
- Shah, A. et al. 2009. Iodoxolone-Based Hypervalent Iodine Reagents. Organic Letters 11(16), pp. 3578-3581. (10.1021/ol9014688)
- Shahzad, S. A. and Wirth, T. 2009. Fast synthesis of benzofluorenes by selenium-mediated carbocyclizations. Angewandte Chemie. International Edition 48(14), pp. 2588-2591. (10.1002/anie.200806148)
- Farooq, U., Shah, A. and Wirth, T. 2009. Hypervalent Bromine Compounds: Smaller, More Reactive Analogues of Hypervalent Iodine Compounds. Angewandte Chemie - International Edition 48(6), pp. 1018-1020. (10.1002/anie.200805027)
- Freudendahl, D. M., Santoro, S., Shahzad, S. A., Santi, C. and Wirth, T. 2009. Green Chemistry with Selenium Reagents: Development of Efficient Catalytic Reactions. Angewandte Chemie - International Edition 48(45), pp. 8409-8411. (10.1002/anie.200903893)
- Uehlin, L. and Wirth, T. 2009. Synthesis of Chiral Acetals by Asymmetric Selenenylations. Phosphorus Sulfur and Silicon and the Related Elements 184(6), pp. 1374-1385. (10.1080/10426500902930167)
- Altermann, S. M. et al. 2008. Catalytic Enantioselective alpha-Oxysulfonylation of Ketones Mediated by Iodoarenes. European Journal of Organic Chemistry(31), pp. 5315-5328. (10.1002/ejoc.200800741)
- Browne, D. M., Niyomura, O. and Wirth, T. 2008. Catalytic addition-elimination reactions towards butenolides. Phosphorus Sulfur and Silicon and the Related Elements 183(4), pp. 1026-1035. (10.1080/10426500801901053)
- Ahmed-Omer, B., Barrow, D. A. and Wirth, T. 2008. Effect of segmented fluid flow, sonication and phase transfer catalysis on biphasic reactions in capillary microreactors. Chemical Engineering Journal 135(S1), pp. S280-S283. (10.1016/j.cej.2007.07.017)
- Richardson, R. D. and Wirth, T. 2008. Tetraazafulvalene: "Organisches" Natrium. Chemie in unserer Zeit 42(3), pp. 190-191. (10.1002/ciuz.200890032)
- Browne, D. M., Niyomura, O. and Wirth, T. 2007. Catalytic use of selenium electrophiles in cyclizations. Organic Letters 9(16), pp. 3169-3171. (10.1021/ol071223y)
- Richardson, R. D., Zayed, J. M., Altermann, S., Smith, D. and Wirth, T. 2007. Tetrafluoro-IBA and -IBX: Hypervalent Iodine Reagents. Angewandte Chemie - International Edition 46(34), pp. 6529-6532. (10.1002/anie.200702313)
- Simmons, S. J., French, A. N., Richardson, R. D. and Wirth, T. 2007. Attempted aziridinations and sulfonilimations using simple iron catalysts and hypervalent iodine reagents. Abstracts of Papers of the American Chemical Society 233, pp. 253-253.
- Paradine, S. M., French, A. N., Page, T. K., Richardson, R. D. and Wirth, T. 2007. Catalytic enantioselective alpha-oxytosylation of propiophenone using chiral hypervalent iodine reagents. Abstracts of Papers of the American Chemical Society 233, pp. 211-211.
- Burgler, F. W., Fragale, G. and Wirth, T. 2007. Stereoselective addition reactions with chalcogen electrophiles. Arkivoc(x), pp. 21-28.
- Ahmed-Omer, B., Brandt, J. C. and Wirth, T. 2007. Advanced organic synthesis using microreactor technology. Organic & Biomolecular Chemistry 5(5), pp. 733-740. (10.1039/B615072A)
- Richardson, R. D., Desaize, M. and Wirth, T. 2007. Hypervalent iodine-mediated aziridination of alkenes: Mechanistic insights and requirements for catalysis. Chemistry - A European Journal 13(23), pp. 6745-6754. (10.1002/chem.200700306)
- Ahmed, B., Barrow, D. A. and Wirth, T. 2006. Enhancement of reaction rates by segmented fluid flow in capillary scale reactors. Advanced Synthesis & Catalysis 348(9), pp. 1043-1048. (10.1002/adsc.200505480)
- Niyomura, O., Cox, M. and Wirth, T. 2006. Electrochemical generation and catalytic use of selenium electrophiles. Synlett(2), pp. 251-254. (10.1055/s-2005-923585)
- Haas, J., Bissmire, S. and Wirth, T. 2005. Iodine Monochloride-Amine Complexes: An Experimental and Computational Approach to New Chiral Electrophiles. Chemistry - A European Journal 11(19), pp. 5777-5785. (10.1002/chem.200500507)
- Yusubov, M. S. and Wirth, T. 2005. Solvent-free reactions with hypervalent iodine reagents. Organic Letters 7(3), pp. 519-521. (10.1021/ol047363e)
- Wirth, T. 2005. Hypervalent iodine chemistry in synthesis: Scope and new directions. Angewandte Chemie - International Edition 44(24), pp. 3656-3665. (10.1002/anie.200500115)
- French, A. N., Cole, J. and Wirth, T. 2004. Tetrahydrofuranylation of alcohols using hypervalent iodine reagents. Synlett(13), pp. 2291-2294. (10.1055/s-2004-832810)
- Khokhar, S. S. and Wirth, T. 2004. Nucleophile-selective selenocyclizations. European Journal of Organic Chemistry(22), pp. 4567-4581. (10.1002/ejoc.200400526)
- Khokhar, S. S. and Wirth, T. 2004. Selenocyclizations: control by coordination and by the counterion. Angewandte Chemie - International Edition 43(5), pp. 631-633. (10.1002/anie.200352884)
- Jauslin, M. L., Wirth, T., Meier, T. and Schoumacher, F. 2002. A cellular model for Friedreich Ataxia reveals small-molecule glutathione peroxidase mimetics as novel treatment strategy. Human Molecular Genetics 11(24), pp. 3055-3063. (10.1093/hmg/11.24.3055)
- Schoumacher, F., Jauslin, M. L., Wirth, T. and Meier, T. 2002. A cellular model for Friedrich ataxia and its application in drug discovery. Neuromuscular Disorders 12(7-8), pp. 774-774.
- Uehlin, L., Fragale, G. and Wirth, T. 2002. New and Efficient Chiral Selenium Electrophiles. Chemistry - A European Journal 8(5), pp. 1125-1133. (10.1002/1521-3765(20020301)8:5<1125::AID-CHEM1125>3.0.CO;2-I)
- Uehlin, L. and Wirth, T. 2001. Novel polymer-bound chiral selenium electrophiles. Organic Letters 3(18), pp. 2931-2933. (10.1021/ol0164435)
- Burpee, S. J., French, A. N., Haas, J. and Wirth, T. 2001. Progress in a computational investigation of conformers of chiral hypervalent iodine compounds. Abstracts of Papers of the American Chemical Society 221, pp. U170-U171.
- Uehlin, L. and Wirth, T. 2001. Chiral selenium electrophiles on solid-support. Chimia 55(1-2), pp. 65-67.
- Wirth, T. 2001. IBX - New reactions with an old reagent. Angewandte Chemie - International Edition 40(15), pp. 2812-2814. (10.1002/1521-3773(20010803)40:15<2812::AID-ANIE2812>3.0.CO;2-X)
- Uehlin, L. and Wirth, T. 2001. Mixed acetals as new precursors for selenium electrophiles. Phosphorus, Sulfur and Silicon and the Related Elements 171(1), pp. 189-194. (10.1080/10426500108046650)
- Spichty, M., Fragale, G. and Wirth, T. 2000. Theoretical investigations on the stereoselective selenenylation reaction of alkenes. Journal of the American Chemical Society 122(44), pp. 10914-10916. (10.1021/ja001602l)
- Wirth, T. 2000. Organoselenium chemistry in stereoselective reactions. Angewandte Chemie - International Edition 39(21), pp. 3740-3749. (10.1002/1521-3773(20001103)39:21<3740::AID-ANIE3740>3.0.CO;2-N)
Book sections
- Singh, F. and Wirth, T. 2024. Selected Diastereoselective Reactions: Hypervalent iodine chemistry. In: Cossy, J. ed. Comprehensive Chirality Volume 1: Chiral Pool and Diastereoselective Synthesis. Elsevier
- Rahman, M. T. and Wirth, T. 2024. Sicherer Umgang mit gefährlichen Chemikalien im Durchfluss. In: Sharma, U. K. and Van der Eycken, E. V. eds. Flow-Chemie für die Synthese von Heterocyclen. Cham: Springer, pp. 375–408., (10.1007/978-3-031-51912-3_8)
- Winterson, B. and Wirth, T. 2020. Electrochemistry in flow for drug discovery. In: Topics in Medicinal Chemistry., Vol. 38. Springer, pp. 121-172., (10.1007/7355_2021_115)
- Folgueiras Amador, A. and Wirth, T. 2019. Electrochemistry under flow conditions. In: Luis, S. V. and Garcia-Verdugo, E. eds. Flow Chemistry: Integrated Approaches for Practical Applications. Green Chemistry Series Royal Society of Chemistry, pp. 153-198., (10.1039/9781788016094-00153)
- Singh, F. V. and Wirth, T. 2019. 7. Selenium and tellurium electrophiles in organic synthesis. In: Laitinen, R. and Oilunkaniemi, R. eds. Selenium and Tellurium Reagents: In Chemistry and Materials Science. De Gruyter, pp. 243-300., (10.1515/9783110529340-007)
- Wirth, T. 2018. Organoselenium chemistry. In: Encyclopedia of Inorganic and Bioinorganic Chemistry. Wiley, (10.1002/9781119951438.eibc2727)
- Singh, F. V. and Wirth, T. 2018. Stereoselective reactions. In: PATAI's Chemistry of Functional Groups. John Wiley, (10.1002/9780470682531.pat0957)
- Wirth, T. and Singh, F. V. 2017. 2.2 Catalytic oxidations with hypervalent iodine. In: Muniz, K. ed. Science of Synthesis: Catalytic Oxidation in Organic Synthesis. Thieme, pp. 29-62.
- Wirth, T. 2017. 35.1.5.1.12 Synthesis of 1-Chloro-n-Heteroatom-Functionalized Alkanes (n ≥2) by Addition across C=C Bonds. In: Science of Synthesis Knowledge Updates 2017/1. Georg Thieme Verlag KG, pp. 403-442., (10.1055/sos-SD-135-00173)
- Wirth, T. 2017. 4.4.19.4 Silyl Sulfides and Selenides. In: Science of Synthesis Knowledge Updates 2017/1., Vol. 1. Georg Thieme Verlag KG, pp. 189-202., (10.1055/sos-SD-104-00365)
- Wirth, T. and Singh, F. V. 2015. Synthesis by substitution of other halogens. In: Science of Synthesis Knowledge Updates: 2015/2. Thieme, pp. 407-414.
- Wirth, T. and Singh, F. V. 2015. Synthesis by substitution of oxygen functionalities. In: Science of Synthesis Knowledge Updates: 2015/2. Thieme, pp. 415-435.
- Wirth, T. and Farid, U. 2012. Stereoselective synthesis with hypervalent iodine reagents. In: Christmann, M. and Bräse, S. eds. Asymmetric Synthesis II. Wiley-VCH, pp. 197-203.
- Singh, F. V. and Wirth, T. 2011. Selenium compounds as ligands and catalysts. In: Wirth, T. ed. Organoselenium Chemistry: Synthesis and Reactions. Weinheim: Wiley-VCH, pp. 321-360.
- Freudendahl, D. M. and Wirth, T. 2011. New selenium electrophiles and their reactivity. In: Woollins, J. D. and Laitinen, R. eds. Selenium and Tellurium Chemistry: From Small Molecules to Biomolecules and Materials. London: Springer, pp. 41-56.
- Rasheed, M., Elmore, S. C. and Wirth, T. 2011. Asymmetric reactions in flow reactors. In: Gruttadauria, M. and Giacalone, F. eds. Catalytic Methods in Asymmetric Synthesis: Advanced Materials, Techniques, and Applications. Hoboken: Wiley, pp. 345-371., (10.1002/9781118087992.ch8)
- Singh, F. V. and Wirth, T. 2011. Stereoselective reactions of organoselenium reagents including catalysis. In: Patai's Chemistry of Functional Groups. John Wiley & Sons, (10.1002/9780470682531.pat0573)
- Ogura, F., Otsubo, T., Wirth, T. and Khan, Z. A. 2010. Dimethyl selenoxide. In: Paquette, L. A. ed. E-EROS encyclopedia of reagents for organic synthesis. Chichester: Wiley
- Brandt, J. C. and Wirth, T. 2009. Homogeneous catalysis using microreactor technology. In: Benaglia, M. ed. Recoverable and Recyclable Catalysts. Oxford: Wiley, pp. 411-425., (10.1002/9780470682005.ch14)
- Choi, J., Shahzad, S. A. and Wirth, T. 2009. Dimethylaluminium methylselenolate. In: Paquette, L. A. ed. Encyclopedia of reagents for organic synthesis (e-EROS). Chichester: Wiley, (10.1002/047084289X.rd300.pub2)
- Marino, J. P., Holub, D. P., Shahzad, S. A. and Wirth, T. 2009. Diphenylselenium bis(trifluoroacetate). In: Paquette, L. A. ed. E-EROS Encyclopedia of Reagents for Organic Synthesis. Chichester: Wiley
- Simpkins, N. S. and Wirth, T. 2009. tert-Butyl Hypoiodite. In: Paquette, L. A. ed. Encyclopedia of Reagents for Organic Synthesis (EROS). 2nd ed.. Chichester: Wiley
- Ahmed-Omer, B. and Wirth, T. 2008. Liquid-liquid biphasic reactions. In: Wirth, T. ed. Microreactors in Organic Synthesis and Catalysis. Weinheim: Wiley-VCH, pp. 122-139., (10.1002/9783527622856.ch4)
- Maruoka, K., Yamamoto, H., Wirth, T. and Khan, Z. A. 2008. Diisobutylaluminium phenyl selenide. In: Paquette, L. A. ed. e-EROS encyclopedia of reagents for organic synthesis. Chichester: Wiley
Books
- Wirth, T. ed. 2011. Organoselenium chemistry: Synthesis and reactions. Weinheim: Wiley-VCH.
- Wirth, T. ed. 2008. Microreactors in organic synthesis and catalysis. Weinheim: Wiley-VCH.
Conferences
- Wirth, T. 2008. Enhancement of reaction rates by segmented flow technique: New aspects for organic synthesis. Presented at: 1st SynTOP conference, Potsdam, Germany, 1-13 June 2008Smart synthesis and technologies for organic processes : 1st SynTOP conference, Potsdam, June 11 - 13, 2008. VDI-Berichte Vol. 2039. Düsseldorf: VDI-Verl. pp. 103-104.
- Mizar, P. and Wirth, T. 2014. Flexible stereoselective functionalizations of ketones through umpolung with hypervalent iodine reagents. Angewandte Chemie International Edition 53(23), pp. 5993-5997. (10.1002/anie.201400405)
- Watts, K., Baker, A. R. and Wirth, T. 2014. Electrochemical synthesis in microreactors. Journal of Flow Chemistry 4(1), pp. 2-11. (10.1556/JFC-D-13-00030)
- Singh, F. V. and Wirth, T. 2014. Hypervalent iodine-catalyzed oxidative functionalizations including stereoselective reactions. Chemistry - An Asian Journal 9(4), pp. 950-971. (10.1002/asia.201301582)
- Farid, U., Malmedy, F., Claveau, R., Albers, L. and Wirth, T. 2013. Stereoselective rearrangements with chiral hypervalent iodine reagents. Angewandte Chemie - International Edition 52(27), pp. 7018-7022. (10.1002/anie.201302358)
- Farid, U. and Wirth, T. 2012. Highly stereoselective metal-free oxyaminations using chiral hypervalent iodine reagents. Angewandte Chemie. International Edition 51(14), pp. 3462-3465. (10.1002/anie.201107703)
- Schäfer, S. and Wirth, T. 2010. A versatile and highly reactive polyfluorinated hypervalent iodine(III) compound. Angewandte Chemie. International Edition 49(15), pp. 2786-2789. (10.1002/anie.200907134)
- Shahzad, S. A. and Wirth, T. 2009. Fast synthesis of benzofluorenes by selenium-mediated carbocyclizations. Angewandte Chemie. International Edition 48(14), pp. 2588-2591. (10.1002/anie.200806148)
- Farooq, U., Shah, A. and Wirth, T. 2009. Hypervalent Bromine Compounds: Smaller, More Reactive Analogues of Hypervalent Iodine Compounds. Angewandte Chemie - International Edition 48(6), pp. 1018-1020. (10.1002/anie.200805027)
- Freudendahl, D. M., Santoro, S., Shahzad, S. A., Santi, C. and Wirth, T. 2009. Green Chemistry with Selenium Reagents: Development of Efficient Catalytic Reactions. Angewandte Chemie - International Edition 48(45), pp. 8409-8411. (10.1002/anie.200903893)
- Richardson, R. D., Zayed, J. M., Altermann, S., Smith, D. and Wirth, T. 2007. Tetrafluoro-IBA and -IBX: Hypervalent Iodine Reagents. Angewandte Chemie - International Edition 46(34), pp. 6529-6532. (10.1002/anie.200702313)
- Wirth, T. 2005. Hypervalent iodine chemistry in synthesis: Scope and new directions. Angewandte Chemie - International Edition 44(24), pp. 3656-3665. (10.1002/anie.200500115)
Research
- Design and Synthesis of New Chiral Selenium Electrophiles: high stereoselectivities are obtained with very simple and easily accessible reagents. Efficient polymer-bound selenium electrophiles with all the advantages in handling and work-up have been synthesized and used in various applications towards natural product synthesis.
- Development of New Hypervalent Iodine Reagents: hypervalent iodine compounds are versatile alternative reagents in reactions traditionally employing heavy metal complexes. The development of chiral reagents led to various new stereoselective reactions. Due to their high reactivity, even the functionalization of alkanes can be achieved under mild reaction conditions.
- Coordination of Chiral Ligands towards Electrophiles: we have developed a reagent-controlled stereoselective iodolactonization reaction applying a new method using a combination of ICl and a primary amine.
- Electrochemical Methods: The selective functionalization of alkenes by combining electrochemical methods with electrophilic reagents leads to promising catalytic reactions. The direct electron transfer at electrode surfaces is frequently referred to as one of the prototypical green technologies of the future.
- Microreactor Technology: The translation of both traditional flask-based chemistry and entirely new procedures on to chipbased platforms becomes more challenging as complexity of operation increases. We are developing new microreactors for reactions under segmented-flow conditions.
- Computational Chemistry: The evaluation of reaction pathways, transition states, intermediates and mechanisms by close interaction of theory and experiment on various levels is supporting many of the research areas mentioned above.
In many areas of Synthetic Organic Chemistry reactions are needed, which produce in good yields stereochemically uniform compounds. In this respect many remarkable efforts have been undertaken and a variety of efficient as well as elegant stereochemical transformations using prochiral substrates are known. However, there are certain classes of compounds which cannot be efficiently used in these reactions. Only a few useful methods are known for the stereoselective functionalization of not or only weakly activated C-H bonds or C=C bonds. In our research projects we are investigating and developing stoichiometric and catalytic reactions leading to products with new stereogenic centers.
For more information on specific projects with Professor Thomas Wirth please review with the Molecular synethsis section of our research project themes.
Teaching
CH5103 Foundations of Organic Chemistry
CH4303 / CH5312 Advanced Organic Chemistry
CH3404 / CHT228 Asymmetric Synthesis of Pharmaceuticals and Natural Products
CHT351 Drug Discovery Chemistry
Biography
Diplom University of Bonn (1989). PhD Technical University of Berlin (1992, S. Blechert); JSPS Fellow, Kyoto University (1993, K. Fuji). Habilitation, University of Basel (1999, B. Giese). Visiting Scientist, University of Toronto (1999). Visiting Scientist, Chuo University, Tokyo (2000). Visiting Scientist, Osaka University (2004). Visiting Scientist, Osaka Prefecture University (2008). Werner Prize, New Swiss Chemical Society (2000). Appointed as Professor of Organic Chemistry, Cardiff, in 2000.
Wolfson Research Merit Award (2016, Royal Society), Elected fellow of The Learned Society of Wales (2016), Bader award (2016, Royal Society of Chemistry), Distinguished Visiting Project Professor at Kyoto University, Japan (2017/2018)
Supervisions
Organic Synthesis
Flow Synthesis
Electrochemistry
Hypervalent Iodine Chemistry
Energetic Materials
Current supervision
Campbell Wolfe
Graduate Demonstrator
Rojan Ali
Research student
Ohud Alzaidi
Research student
Bethan Winterson
Research student
Huw Chadwick
Research student
Rawiyah Alkahtani
Research student
Noura Alqahtani
Research student