![Jamie Wood BSc (Hons), MSc, PhD](https://profiles-cardiff.imgix.net/attachments/7045?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Jamie Wood
(he/him)
BSc (Hons), MSc, PhD
Teams and roles for Jamie Wood
Post-Doctoral Fellowship Researcher
School of Biosciences
Research student
School of Biosciences
Overview
I am a Waterloo post-doctoral fellow based in the Neuroscience and Mental Health Innovation Institute (NMHII), working on the role of epigenetics and neurodevelopment. I have a keen personal interest in translating novel bioscience into the commercial setting. I have experience working in industry, government and academia, with 8+ years developing cell and gene therapies in the regulatory landscape.
My current work is centralised around the role of epigenetics and microRNAs during human neurodevelopment, and how their dysregulation leads to the development of various neurodevelopmental disorders. I utilise a combination of human stem cell based assays and computational biology to generate disease models, with the aim of identifying key network nodes and pharmacological analysis.
Publication
2024
- Wood, J. 2024. The epigenetic network mediated by Ehmt1 and its role in neurodevelopment disorders. PhD Thesis, Cardiff University.
2023
- Dec, K., Alsaqati, M., Morgan, J., Deshpande, S., Wood, J., Hall, J. and Harwood, A. J. 2023. A high ratio of linoleic acid (n-6 PUFA) to alpha-linolenic acid (n-3 PUFA) adversely affects early stage of human neuronal differentiation and electrophysiological activity of glutamatergic neurons in vitro. Frontiers in Cell and Developmental Biology 11, article number: 1166808. (10.3389/fcell.2023.1166808)
2022
- Alsaqati, M. et al. 2022. NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia. Translational Psychiatry 12, article number: 438. (10.1038/s41398-022-02199-z)
Articles
- Dec, K., Alsaqati, M., Morgan, J., Deshpande, S., Wood, J., Hall, J. and Harwood, A. J. 2023. A high ratio of linoleic acid (n-6 PUFA) to alpha-linolenic acid (n-3 PUFA) adversely affects early stage of human neuronal differentiation and electrophysiological activity of glutamatergic neurons in vitro. Frontiers in Cell and Developmental Biology 11, article number: 1166808. (10.3389/fcell.2023.1166808)
- Alsaqati, M. et al. 2022. NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia. Translational Psychiatry 12, article number: 438. (10.1038/s41398-022-02199-z)
Thesis
- Wood, J. 2024. The epigenetic network mediated by Ehmt1 and its role in neurodevelopment disorders. PhD Thesis, Cardiff University.
Biography
I obtained a BSc in Animal Science from the University at Nottingham in 2013, during which time I completed a research project with the late Keith Campbell which founded my interest in the stem cell field. In 2015 I went on to complete an MSc in Stem Cell Technology, during which time I worked to genetically mature stem cell-derived cardiomyocytes using novel CRISPR based optogenetic technology. Beyond my academic research I have also worked within the industrial sector as a cell biologist with Crown Bioscience and as a senior stem cell scientist within the civil service, working at the Medicines and Healthcare product Regulatory Agency (MHRA).
Most recently I completed my PhD as part of the GW4 dcotoral training programme at Cardiff University in 2024. I studied how the epigenetic regulator EHMT1 controls the genetic network that underlies human neurodevelopment and how its dysfunction results in the disorder, Kleefstra Syndrome. During this time I was also fortunate enough to conduct a 3 month placement with AstraZeneca in Gothenburg, Sweden, working as part of their cell therpay division.
Today I hold a Waterloo funded fellowship, where my work aims to investigate how epigenetic regulators shape the early fate decisions of stem cells during neurodevelopment.
Committees and reviewing
I currently sit on Cardiff Universities Biobank's Scientific Review Comittee.
Previously I have sat as a specialist reviewer on the UK Governbments Human Materials Advisory Comittee (HuMAC).
Contact Details
Research themes
Specialisms
- Neurodevelopment
- Epigenetics
- microRNA
- Bioinformatics and computational biology