![Chris Yang](https://profiles-cardiff.imgix.net/attachments/3954?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Dr Chris Yang
(he/him)
- Available for postgraduate supervision
Teams and roles for Chris Yang
Senior Lecturer
Overview
Dr. Xin Yang (Chris) is the leader of the Medical Ultrasound and Sensor Laboratory (MUSL) at the School of Engineering, Cardiff University. His research exemplifies cutting-edge interdisciplinary work, bringing together expertise from engineering, life sciences, and artificial intelligence to develop next-generation biomedical technologies.
At the core of Dr. Yang’s research is the development of acoustofluidic devices—innovative systems that harness sound waves to manipulate fluids and microscopic particles. These tools enable precise and label-free handling of biological samples, with wide-reaching applications such as early cancer diagnosis, drug delivery, biosample enrichment, stem cell differentiation, and personalised medicine.
Dr. Yang's interdisciplinary work draws on fields including microfluidics, materials science, electronics, mechanical engineering, AI, and clinical sciences. For instance, his recent work on wirelessly powered acoustic drug delivery systems (Journal of Controlled Release, 2025) and surface acoustic wave-based cytometry platforms (Advanced Science, 2024) demonstrates strong integration between device engineering and biomedical application. In addition, his collaborations with clinicians and pharmacologists have led to impactful discoveries such as real-time functional imaging of metabolic enzymes (Small, 2025) and acoustic systems for blood-brain barrier modulation (Biomaterials Research, 2023).
Dr. Yang’s contributions are not only scientific but also technological, with numerous innovations in flexible electronics, wearables, and AI-integrated diagnostic systems. His research has attracted over £1 million in competitive funding from the EPSRC, Royal Society, Wellcome Trust, GCRF, and various industrial partners. He is actively involved in national expert panels (EPSRC, MRC, BBSRC) and leads initiatives within networks like the UK Organ-on-a-Chip and UK Acoustofluidics Group.
Dr. Yang has published over 40 peer-reviewed journal papers in high-impact venues such as Nano Letters, Lab on a Chip, Small, and Acta Biomaterialia, and authored eight books. His team’s work continues to push the boundaries of interdisciplinary research, demonstrating how converging fields can unlock new solutions to pressing biomedical challenges.
PhD candidates are welcome to apply for PGR (Postgraduate Research) studies. Our group is actively seeking highly motivated early-career researchers interested in shaping the future of health technologies, drug discovery, and life sciences.
We offer exciting opportunities in several cutting-edge research areas that are especially attractive to young, aspiring scientists:
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Single-cell technologies – from acoustic tweezers to high-throughput sorting and precision dispensing for personalized medicine.
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Smart biomaterials & tissue engineering – for regenerative medicine and advanced therapeutic strategies.
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Lab-on-a-chip systems & microfluidics – enabling point-of-care diagnostics and real-time biological analysis.
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AI-assisted drug screening – integrating machine learning with molecular biology for faster, targeted drug discovery.
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Acoustic & photonic manipulation – novel methods for non-invasive control of cells and molecules.
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Biosensing & wearable health tech – building next-generation tools for real-time, continuous health monitoring.
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Synthetic biology – engineering biological systems for therapeutic, industrial, or environmental applications.
Publication
2025
- Zhang, J. et al. 2025. Wearable transdermal drug delivery system controlled by wirelessly powered acoustic waves. Journal of Controlled Release 381, article number: 113619. (10.1016/j.jconrel.2025.113619)
- Zhang, J. et al. 2025. Flexible surface acoustic wave technology for enhancing transdermal drug delivery. Drug Delivery and Translational Research 15(4), pp. 1363-1375. (10.1007/s13346-024-01682-y)
- Li, Y., Liang, D., Kabla, A., Zhang, Y., Ma, J. and Yang, X. 2025. Dependence of acoustophoretic aggregation on the impedance of microchannel's walls. Computer Methods and Programs in Biomedicine 260, article number: 108530. (10.1016/j.cmpb.2024.108530)
- Sun, C. et al. 2025. Enhanced integrated acoustofluidics with printed circuit board electrodes attached to piezoelectric film coated substrate. Ultrasonics 147, article number: 107531. (10.1016/j.ultras.2024.107531)
- Yu, M. et al. 2025. Upconversion optical fiber microsphere sensor designed for precise measurement of FPGA temperature. Optics Express 33(6), pp. 13972-13985. (10.1364/OE.543454)
- Zhang, F. et al. 2025. Functional imaging of CYP3A4 at multiple dimensions using an AI‐driven high performance fluorogenic substrate. Small, article number: 2412178. (10.1002/smll.202412178)
- Zhang, F. et al. 2025. Discovery of a novel AhR–CYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assay. Acta Pharmaceutica Sinica B 15(1), pp. 508-525. (10.1016/j.apsb.2024.09.014)
- Stringer, M. et al. 2025. Multidirectionally patterned interdigital transducers for enhancing acoustofluidic streaming with flexible printed circuit board. Advanced Functional Materials, article number: 2421308. (10.1002/adfm.202421308)
2024
- Zhang, X. et al. 2024. Surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) for pre‐cytopathological screening. Advanced Science 11(39), article number: 2403574. (10.1002/advs.202403574)
- Yu, Y. et al. 2024. Acoustic wave-driven microdroplet enrichment for surface-enhanced Raman spectroscopy detection. Optics 5(4), pp. 364-377. (10.3390/opt5040027)
- Dong, J., Liang, D., Kabla, A. J., Chen, X. and Yang, X. 2024. A combination of acoustophoresis and thermophoresis for enriching nanoparticles. Physics of Fluids 36(9), article number: 92005. (10.1063/5.0222212)
- Wu, Z. et al. 2024. Investigation of piezoelectric printing devices for oil-free and on-demand picolitre monodisperse droplet generation. Scientific Reports 14(1), article number: 17104. (10.1038/s41598-024-67849-2)
- Wu, Z. et al. 2024. Investigation of piezoelectric printing devices for oil-free and on-demand picolitre monodisperse droplet generation. Scientific Reports 14(1), article number: 17104. (10.1038/s41598-024-67849-2)
- Wang, Q. et al. 2024. Acoustofluidic patterning in glass capillaries using travelling acoustic waves based on thin film flexible platform. Ultrasonics 136, article number: 107149. (10.1016/j.ultras.2023.107149)
- Dong, J., Liang, D., Chen, X. and Yang, X. 2024. Influences of laser heating parameters on thermophoretic enrichment of nanoparticles. International Journal of Heat and Mass Transfer 218, article number: 124765. (10.1016/j.ijheatmasstransfer.2023.124765)
2023
- Li, Y., Liang, D., Kabla, A., Zhang, Y. and Yang, X. 2023. Sensitivity of acoustofluidic particle manipulation to microchannel height in standing surface acoustic wave-based microfluidic devices. Physics of Fluids 35(12), article number: 122018. (10.1063/5.0177118)
- Wu, F. et al. 2023. Power-controlled acoustofluidic manipulation of microparticles. Ultrasonics 134, article number: 107087. (10.1016/j.ultras.2023.107087)
- Dumcius, P. et al. 2023. Dual-wave acoustofluidic centrifuge for ultrafast concentration of nanoparticles and extracellular vesicles (small 35/2023). Small 19(35), article number: 2370274. (10.1002/smll.202370274)
- Dumcius, P. et al. 2023. Dual-Wave Acoustofluidic Centrifuge for Ultrafast Concentration of Nanoparticles and Extracellular Vesicles. Small 19(35), article number: 2300390. (10.1002/smll.202300390)
- Wang, K. et al. 2023. Open source board based acoustofluidic transwells for reversible disruption of the blood–brain barrier for therapeutic delivery. Biomaterials Research 27(1), article number: 69. (10.1186/s40824-023-00406-6)
- Wang, H. et al. 2023. An enhanced tilted-angle acoustic tweezer for mechanical phenotyping of cancer cells. Analytica Chimica Acta 1255, article number: 341120. (10.1016/j.aca.2023.341120)
- Wu, Z. et al. 2023. Investigation of high-Q lithium niobate-based double ring resonator used in RF signal modulation. Applied Sciences 13(7), article number: 4648. (10.3390/app13074648)
- Stringer Martin, M. et al. 2023. Methodologies, technologies and strategies for acoustic streaming based Acoustofluidics. Applied Physics Reviews 10, article number: 11315.
- Wang, H. et al. 2023. Modelling hybrid acoustofluidic devices for enhancing nano- and micro-particle manipulation in microfluidics. Applied Acoustics 205, article number: 109258. (10.1016/j.apacoust.2023.109258)
2022
- Sun, C. et al. 2022. Acoustically accelerated neural differentiation of human embryonic stem cells. Acta Biomaterialia 151, pp. 333-345. (10.1016/j.actbio.2022.07.041)
- Liu, L., Zhou, J., Tan, K., Zhang, H., Yang, X., Duan, H. and Fu, Y. 2022. A simplified three-dimensional numerical simulation approach for surface acoustic wave tweezers. Ultrasonics 125, article number: 106797. (10.1016/j.ultras.2022.106797)
- Alqazzaz, S. et al. 2022. Combined features in region of interest for brain tumor segmentation. Journal of Digital Imaging 35, pp. 938-946. (10.1007/s10278-022-00602-1)
- Wu, Z. et al. 2022. Tunable electromagnetically induced transparent window of terahertz metamaterials and Its sensing performance. Applied Sciences 12(14), article number: 7057. (10.3390/app12147057)
- Zahertar, S., Torun, H., Sun, C., Markwell, C., Dong, Y., Yang, X. and Fu, Y. 2022. Flexible platform of acoustofluidics and metamaterials with decoupled resonant frequencies. Sensors 22(12), article number: 4344. (10.3390/s22124344)
2021
- Dong, J., Liang, D., Yang, X. and Sun, C. 2021. Influences of microparticle radius and microchannel height on SSAW-based acoustophoretic aggregation. Ultrasonics 117, article number: 106547. (10.1016/j.ultras.2021.106547)
- Ma, J., Liang, D., Yang, X., Wang, H., Wu, F., Sun, C. and Xiao, Y. 2021. Numerical study of acoustophoretic manipulation of particles in microfluidic channels. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 235(10), pp. 1163-1174. (10.1177/09544119211024775)
- Mikhaylov, R. et al. 2021. A reconfigurable and portable acoustofluidic system based on flexible printed circuit board for the manipulation of microspheres. Journal of Micromechanics and Microengineering 31(7), article number: 74003. (10.1088/1361-6439/ac0515)
- Wang, Y. et al. 2021. Flexible/bendable acoustofluidics based on thin-film surface acoustic waves on thin aluminum sheets. ACS Applied Materials and Interfaces 13(14), pp. 16978-16986. (10.1021/acsami.0c22576)
- Latham, J., Hicks, Y. A., Yang, X., Setchi, R. and Rainer, T. 2021. Stable automatic envelope estimation for noisy doppler ultrasound. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 68(3), pp. 465-481. (10.1109/TUFFC.2020.3011823)
- Wu, Z. et al. 2021. Simulation and analysis of microring electric field sensor based on a lithium niobate-on-insulator. Crystals 11(4), pp. 359-. (10.3390/cryst11040359)
- Zhang, Q., Wang, Y., Li, D., Yang, X., Xie, J. and Fu, Y. 2021. Bending behaviors of flexible acoustic wave devices under non-uniform elasto-plastic deformation. Applied Physics Letters 118(12), article number: 121601. (10.1063/5.0043550)
- Al-qazzaz, S., Sun, X., Yang, H., Yang, Y., Xu, R., Nokes, L. and Yang, X. 2021. Image classification-based brain tumour tissue segmentation. Multimedia Tools and Applications 80, pp. 993-1008. (10.1007/s11042-020-09661-4)
2020
- Sun, C. et al. 2020. Thin film gallium nitride (GaN) based acoustofluidic tweezer: modelling and microparticle manipulation. Ultrasonics 108, article number: 106202. (10.1016/j.ultras.2020.106202)
- Sun, C. et al. 2020. Gallium nitride: a versatile compound semiconductor as novel piezoelectric film for acoustic tweezer in manipulation of cancer cells. IEEE Transactions on Electron Devices 67(8), pp. 3355-3361. (10.1109/TED.2020.3002498)
- Mikhaylov, R. et al. 2020. Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip 20(10), pp. 1807-1814. (10.1039/C9LC01192G)
- Tao, R. et al. 2020. Hierarchical nanotexturing enables acoustofluidics on slippery yet sticky, flexible surfaces. Nano Letters 20(5), pp. 3263-3270. (10.1021/acs.nanolett.0c00005)
- Tao, R. et al. 2020. Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes. Lab on a Chip 20(5), pp. 1002-1011. (10.1039/C9LC01189G)
2019
- Tao, X. et al. 2019. 3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves. Sensors and Actuators B: Chemical 299, article number: 126991. (10.1016/j.snb.2019.126991)
- Alqazzaz, S., Sun, X., Yang, X. and Nokes, L. 2019. Automated brain tumor segmentation on multi-modal MR image using SegNet. Computational Visual Media 5(2), pp. 209-219. (10.1007/s41095-019-0139-y)
- Wu, Z. et al. 2019. Polymer-based device fabrication and applications using direct laser writing technology. Polymers 11(3), article number: 553. (10.3390/polym11030553)
2018
- Yu, J., Wu, Z., Yang, X., Han, X. and Zhao, M. 2018. Tilted fiber bragg grating sensor using chemical plating of a palladium membrane for the detection of hydrogen leakage. Sensors 18(12), pp. 4478. (10.3390/s18124478)
- Alzamil, Y., Hicks, Y., Yang, X. and Marshall, C. 2018. Optimising graphical techniques applied to irreversible tracers. Presented at: 5th International Conference on Bioimaging, Optimising Graphical Techniques Applied to Irreversible Tracers, 19 - 21 January 2018.
2017
- Li, J., Wu, F., Wang, H., Cuenca, J., Yang, X. and Barrow, D. 2017. An automated system for the shape optimization of double emulsion droplets used in the fabrication of Inertial Fusion Energy target shells. Presented at: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Cardiff, 22-26 October 2017.
2016
- Elmasri, K., Hicks, Y. A., Yang, X., Sun, X., Pettit, R. J. and Evans, W. 2016. Automatic detection and quantification of abdominal aortic calcification in dual energy X-ray absorptiometry. Procedia Computer Science 96, pp. 1011-1021. (10.1016/j.procs.2016.08.116)
2015
- Abduljabar, A. A., Yang, X., Barrow, D. A. and Porch, A. 2015. Modelling and measurements of the microwave dielectric properties of microspheres. IEEE Transactions on Microwave Theory and Techniques 63(12), pp. 4492-4500. (10.1109/TMTT.2015.2495247)
- Al-Qahtani, M., Alwahiby, M., Abdelhamid, M., Mirza, E. H. and Yang, X. 2015. Wireless platform for real-time electrocardiography (ECG) recording and analysis. Presented at: 9th International Conference on Bioinformatics and Biomedical Engineering, ICBBE 2015;, Shanghai; China, 18 - 20 September 2015 Presented at Chou, J. ed.
- Abduljabar, A., Yang, X., Barrow, D. and Porch, A. 2015. Microstrip split ring resonator for microsphere detection and characterization. Presented at: 2015 IEEE MTT-S International Microwave Symposium, Phoenix, AZ, USA, 17-22 May 20152015 IEEE MTT-S International Microwave Symposium. pp. 1-4.
2013
- Yang, X., Sun, C., Anderson, T., Moran, C. A., Hadoke, P. W. F., Gray, G. A. and Hoskins, P. R. 2013. Assessment of spectral doppler in preclinical ultrasound using a small-size rotating phantom. Ultrasound in Medicine & Biology 39(8), pp. 1491-1499. (10.1016/j.ultrasmedbio.2013.03.013)
- Yang, X., Hollis, L., Adams, F., Khan, F. and Hoskins, P. R. 2013. A fast method to estimate the wall shear stress waveform in arteries. Ultrasound 21(1), pp. 23-28. (10.1177/1742271X12473871)
2012
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2012. The volume of the neovascularity and its clinical implications in Achilles tendinopathy. Ultrasound in Medicine & Biology 38(11), pp. 1887-1895. (10.1016/j.ultrasmedbio.2012.07.002)
- Yang, X., Anderson, T., Moran, C. M., Hadoke, P., Gray, G. and Hopkins, P. 2012. Validation of velocity measurement of preclinical ultrasound. Presented at: Ultrasound 2012: 44th Annual Scientific Meeting of the British Medical Ultrasound Society, Telford, UK, 10 - 12 December 2012.
- Yang, X., Hu, W., Zhang, Y., Nokes, L. D. M., Wang, Y. F. and Liu, X. Q. 2012. A simple guide to analog electronic circuits, devices, and applications. Beijing: Publishing House of Electronic Industry.
- Hollis, L., Yang, X., Adams, F., Khan, F. and Hoskins, P. R. 2012. Feasibility study for estimation of wall shear rate in flow mediated dilation. Presented at: 44th Annual Scientific Meeting of the British Medical Ultrasound Society, Telford, UK, 10-12 December, 2012.
2011
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2011. A novel 3-D power Doppler ultrasound approach to the quantification of Achilles tendon neovascularity. Ultrasound in Medicine & Biology 37(7), pp. 1046-1055. (10.1016/j.ultrasmedbio.2011.04.008)
- Yang, X., Coleman, D. P., Pugh, N. D., Liu, W. and Nokes, L. D. M. 2011. Quantitative assessment of intra-vascular volume in human Achilles tendinopathy. Journal of Medical Engineering & Technology 35(3-4), pp. 172-178. (10.3109/03091902.2011.558170)
- Yang, X., Zhang, Y. Q., Zhang, K. L., Nokes, L. D. M., Wang, Y. F. and Liu, X. Q. 2011. All you need to know about the 8051 microcontroller. Beijing: Publishing House of Electronic Industry.
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2011. Quantifying neovascularization in Achilles tendinopathy using 3D power Doppler ultrasound: the correlation between the clinical severity and the volume of neovascularization. Presented at: IPEM Conferences: The Physics & Technology of Medical Ultrasound, York, UK, 16 - 17 March 2011.
2010
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. m. 2010. Quantifying neovascularization in Achilles tendinopathy. Presented at: All-Wales IPEM Scientific Conference, Cardiff, UK, 10 June 2010.
- Yang, X., Pugh, N. D., Coleman, D. P. and Nokes, L. D. M. 2010. Are Doppler studies a useful method of assessing neovascularization in human Achilles tendinopathy? A systematic review and suggestions for optimizing machine settings. Journal of Medical Engineering & Technology 35(7-8), pp. 365-372. (10.3109/03091902.2010.497892)
- Yang, X., Nokes, L. D. M., Wang, Y. and Liu, X. 2010. Circuit design from the ground up (2nd edition). Beijing: Publishing House of Electronic Industry.
- Yang, X., Wang, Y. F., Liu, X. Q. and Zhang, Y. 2010. 8051 microcontroller: a project based introduction. Beijing: Tsinghua University Press.
2009
- Yang, X., Wang, Z., Chen, X. and Wentling, C. 2009. Electronic components and circuit design in applications. Beijing: Electronic Industry Press.
2008
- Yang, X., Wang, Y. F., Liu, X. Q. and Zhang, Y. 2008. 8051 Microcontroller: an application based introduction. Beijing: Tsinghua University Press.
2006
- Yang, X., Wang, Y. F. and Liu, X. Q. 2006. Circuit design and simulation with Multisim 8 & Protel 2004. Beijing: Tsinghua University Press.
2005
- Yang, X. and Zhang, K. L. 2005. The research of finger pulse analysis system with AT89C2051. Medical Equipment
- Yang, X., Wang, Y. F. and Liu, X. Q. 2005. Circuit design from the ground up. 1st ed.. Beijing: Tsinghua University Press.
Articles
- Zhang, J. et al. 2025. Wearable transdermal drug delivery system controlled by wirelessly powered acoustic waves. Journal of Controlled Release 381, article number: 113619. (10.1016/j.jconrel.2025.113619)
- Zhang, J. et al. 2025. Flexible surface acoustic wave technology for enhancing transdermal drug delivery. Drug Delivery and Translational Research 15(4), pp. 1363-1375. (10.1007/s13346-024-01682-y)
- Li, Y., Liang, D., Kabla, A., Zhang, Y., Ma, J. and Yang, X. 2025. Dependence of acoustophoretic aggregation on the impedance of microchannel's walls. Computer Methods and Programs in Biomedicine 260, article number: 108530. (10.1016/j.cmpb.2024.108530)
- Sun, C. et al. 2025. Enhanced integrated acoustofluidics with printed circuit board electrodes attached to piezoelectric film coated substrate. Ultrasonics 147, article number: 107531. (10.1016/j.ultras.2024.107531)
- Yu, M. et al. 2025. Upconversion optical fiber microsphere sensor designed for precise measurement of FPGA temperature. Optics Express 33(6), pp. 13972-13985. (10.1364/OE.543454)
- Zhang, F. et al. 2025. Functional imaging of CYP3A4 at multiple dimensions using an AI‐driven high performance fluorogenic substrate. Small, article number: 2412178. (10.1002/smll.202412178)
- Zhang, F. et al. 2025. Discovery of a novel AhR–CYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assay. Acta Pharmaceutica Sinica B 15(1), pp. 508-525. (10.1016/j.apsb.2024.09.014)
- Stringer, M. et al. 2025. Multidirectionally patterned interdigital transducers for enhancing acoustofluidic streaming with flexible printed circuit board. Advanced Functional Materials, article number: 2421308. (10.1002/adfm.202421308)
- Zhang, X. et al. 2024. Surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) for pre‐cytopathological screening. Advanced Science 11(39), article number: 2403574. (10.1002/advs.202403574)
- Yu, Y. et al. 2024. Acoustic wave-driven microdroplet enrichment for surface-enhanced Raman spectroscopy detection. Optics 5(4), pp. 364-377. (10.3390/opt5040027)
- Dong, J., Liang, D., Kabla, A. J., Chen, X. and Yang, X. 2024. A combination of acoustophoresis and thermophoresis for enriching nanoparticles. Physics of Fluids 36(9), article number: 92005. (10.1063/5.0222212)
- Wu, Z. et al. 2024. Investigation of piezoelectric printing devices for oil-free and on-demand picolitre monodisperse droplet generation. Scientific Reports 14(1), article number: 17104. (10.1038/s41598-024-67849-2)
- Wu, Z. et al. 2024. Investigation of piezoelectric printing devices for oil-free and on-demand picolitre monodisperse droplet generation. Scientific Reports 14(1), article number: 17104. (10.1038/s41598-024-67849-2)
- Wang, Q. et al. 2024. Acoustofluidic patterning in glass capillaries using travelling acoustic waves based on thin film flexible platform. Ultrasonics 136, article number: 107149. (10.1016/j.ultras.2023.107149)
- Dong, J., Liang, D., Chen, X. and Yang, X. 2024. Influences of laser heating parameters on thermophoretic enrichment of nanoparticles. International Journal of Heat and Mass Transfer 218, article number: 124765. (10.1016/j.ijheatmasstransfer.2023.124765)
- Li, Y., Liang, D., Kabla, A., Zhang, Y. and Yang, X. 2023. Sensitivity of acoustofluidic particle manipulation to microchannel height in standing surface acoustic wave-based microfluidic devices. Physics of Fluids 35(12), article number: 122018. (10.1063/5.0177118)
- Wu, F. et al. 2023. Power-controlled acoustofluidic manipulation of microparticles. Ultrasonics 134, article number: 107087. (10.1016/j.ultras.2023.107087)
- Dumcius, P. et al. 2023. Dual-wave acoustofluidic centrifuge for ultrafast concentration of nanoparticles and extracellular vesicles (small 35/2023). Small 19(35), article number: 2370274. (10.1002/smll.202370274)
- Dumcius, P. et al. 2023. Dual-Wave Acoustofluidic Centrifuge for Ultrafast Concentration of Nanoparticles and Extracellular Vesicles. Small 19(35), article number: 2300390. (10.1002/smll.202300390)
- Wang, K. et al. 2023. Open source board based acoustofluidic transwells for reversible disruption of the blood–brain barrier for therapeutic delivery. Biomaterials Research 27(1), article number: 69. (10.1186/s40824-023-00406-6)
- Wang, H. et al. 2023. An enhanced tilted-angle acoustic tweezer for mechanical phenotyping of cancer cells. Analytica Chimica Acta 1255, article number: 341120. (10.1016/j.aca.2023.341120)
- Wu, Z. et al. 2023. Investigation of high-Q lithium niobate-based double ring resonator used in RF signal modulation. Applied Sciences 13(7), article number: 4648. (10.3390/app13074648)
- Stringer Martin, M. et al. 2023. Methodologies, technologies and strategies for acoustic streaming based Acoustofluidics. Applied Physics Reviews 10, article number: 11315.
- Wang, H. et al. 2023. Modelling hybrid acoustofluidic devices for enhancing nano- and micro-particle manipulation in microfluidics. Applied Acoustics 205, article number: 109258. (10.1016/j.apacoust.2023.109258)
- Sun, C. et al. 2022. Acoustically accelerated neural differentiation of human embryonic stem cells. Acta Biomaterialia 151, pp. 333-345. (10.1016/j.actbio.2022.07.041)
- Liu, L., Zhou, J., Tan, K., Zhang, H., Yang, X., Duan, H. and Fu, Y. 2022. A simplified three-dimensional numerical simulation approach for surface acoustic wave tweezers. Ultrasonics 125, article number: 106797. (10.1016/j.ultras.2022.106797)
- Alqazzaz, S. et al. 2022. Combined features in region of interest for brain tumor segmentation. Journal of Digital Imaging 35, pp. 938-946. (10.1007/s10278-022-00602-1)
- Wu, Z. et al. 2022. Tunable electromagnetically induced transparent window of terahertz metamaterials and Its sensing performance. Applied Sciences 12(14), article number: 7057. (10.3390/app12147057)
- Zahertar, S., Torun, H., Sun, C., Markwell, C., Dong, Y., Yang, X. and Fu, Y. 2022. Flexible platform of acoustofluidics and metamaterials with decoupled resonant frequencies. Sensors 22(12), article number: 4344. (10.3390/s22124344)
- Dong, J., Liang, D., Yang, X. and Sun, C. 2021. Influences of microparticle radius and microchannel height on SSAW-based acoustophoretic aggregation. Ultrasonics 117, article number: 106547. (10.1016/j.ultras.2021.106547)
- Ma, J., Liang, D., Yang, X., Wang, H., Wu, F., Sun, C. and Xiao, Y. 2021. Numerical study of acoustophoretic manipulation of particles in microfluidic channels. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 235(10), pp. 1163-1174. (10.1177/09544119211024775)
- Mikhaylov, R. et al. 2021. A reconfigurable and portable acoustofluidic system based on flexible printed circuit board for the manipulation of microspheres. Journal of Micromechanics and Microengineering 31(7), article number: 74003. (10.1088/1361-6439/ac0515)
- Wang, Y. et al. 2021. Flexible/bendable acoustofluidics based on thin-film surface acoustic waves on thin aluminum sheets. ACS Applied Materials and Interfaces 13(14), pp. 16978-16986. (10.1021/acsami.0c22576)
- Latham, J., Hicks, Y. A., Yang, X., Setchi, R. and Rainer, T. 2021. Stable automatic envelope estimation for noisy doppler ultrasound. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 68(3), pp. 465-481. (10.1109/TUFFC.2020.3011823)
- Wu, Z. et al. 2021. Simulation and analysis of microring electric field sensor based on a lithium niobate-on-insulator. Crystals 11(4), pp. 359-. (10.3390/cryst11040359)
- Zhang, Q., Wang, Y., Li, D., Yang, X., Xie, J. and Fu, Y. 2021. Bending behaviors of flexible acoustic wave devices under non-uniform elasto-plastic deformation. Applied Physics Letters 118(12), article number: 121601. (10.1063/5.0043550)
- Al-qazzaz, S., Sun, X., Yang, H., Yang, Y., Xu, R., Nokes, L. and Yang, X. 2021. Image classification-based brain tumour tissue segmentation. Multimedia Tools and Applications 80, pp. 993-1008. (10.1007/s11042-020-09661-4)
- Sun, C. et al. 2020. Thin film gallium nitride (GaN) based acoustofluidic tweezer: modelling and microparticle manipulation. Ultrasonics 108, article number: 106202. (10.1016/j.ultras.2020.106202)
- Sun, C. et al. 2020. Gallium nitride: a versatile compound semiconductor as novel piezoelectric film for acoustic tweezer in manipulation of cancer cells. IEEE Transactions on Electron Devices 67(8), pp. 3355-3361. (10.1109/TED.2020.3002498)
- Mikhaylov, R. et al. 2020. Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip 20(10), pp. 1807-1814. (10.1039/C9LC01192G)
- Tao, R. et al. 2020. Hierarchical nanotexturing enables acoustofluidics on slippery yet sticky, flexible surfaces. Nano Letters 20(5), pp. 3263-3270. (10.1021/acs.nanolett.0c00005)
- Tao, R. et al. 2020. Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes. Lab on a Chip 20(5), pp. 1002-1011. (10.1039/C9LC01189G)
- Tao, X. et al. 2019. 3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves. Sensors and Actuators B: Chemical 299, article number: 126991. (10.1016/j.snb.2019.126991)
- Alqazzaz, S., Sun, X., Yang, X. and Nokes, L. 2019. Automated brain tumor segmentation on multi-modal MR image using SegNet. Computational Visual Media 5(2), pp. 209-219. (10.1007/s41095-019-0139-y)
- Wu, Z. et al. 2019. Polymer-based device fabrication and applications using direct laser writing technology. Polymers 11(3), article number: 553. (10.3390/polym11030553)
- Yu, J., Wu, Z., Yang, X., Han, X. and Zhao, M. 2018. Tilted fiber bragg grating sensor using chemical plating of a palladium membrane for the detection of hydrogen leakage. Sensors 18(12), pp. 4478. (10.3390/s18124478)
- Elmasri, K., Hicks, Y. A., Yang, X., Sun, X., Pettit, R. J. and Evans, W. 2016. Automatic detection and quantification of abdominal aortic calcification in dual energy X-ray absorptiometry. Procedia Computer Science 96, pp. 1011-1021. (10.1016/j.procs.2016.08.116)
- Abduljabar, A. A., Yang, X., Barrow, D. A. and Porch, A. 2015. Modelling and measurements of the microwave dielectric properties of microspheres. IEEE Transactions on Microwave Theory and Techniques 63(12), pp. 4492-4500. (10.1109/TMTT.2015.2495247)
- Yang, X., Sun, C., Anderson, T., Moran, C. A., Hadoke, P. W. F., Gray, G. A. and Hoskins, P. R. 2013. Assessment of spectral doppler in preclinical ultrasound using a small-size rotating phantom. Ultrasound in Medicine & Biology 39(8), pp. 1491-1499. (10.1016/j.ultrasmedbio.2013.03.013)
- Yang, X., Hollis, L., Adams, F., Khan, F. and Hoskins, P. R. 2013. A fast method to estimate the wall shear stress waveform in arteries. Ultrasound 21(1), pp. 23-28. (10.1177/1742271X12473871)
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2012. The volume of the neovascularity and its clinical implications in Achilles tendinopathy. Ultrasound in Medicine & Biology 38(11), pp. 1887-1895. (10.1016/j.ultrasmedbio.2012.07.002)
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2011. A novel 3-D power Doppler ultrasound approach to the quantification of Achilles tendon neovascularity. Ultrasound in Medicine & Biology 37(7), pp. 1046-1055. (10.1016/j.ultrasmedbio.2011.04.008)
- Yang, X., Coleman, D. P., Pugh, N. D., Liu, W. and Nokes, L. D. M. 2011. Quantitative assessment of intra-vascular volume in human Achilles tendinopathy. Journal of Medical Engineering & Technology 35(3-4), pp. 172-178. (10.3109/03091902.2011.558170)
- Yang, X., Pugh, N. D., Coleman, D. P. and Nokes, L. D. M. 2010. Are Doppler studies a useful method of assessing neovascularization in human Achilles tendinopathy? A systematic review and suggestions for optimizing machine settings. Journal of Medical Engineering & Technology 35(7-8), pp. 365-372. (10.3109/03091902.2010.497892)
- Yang, X. and Zhang, K. L. 2005. The research of finger pulse analysis system with AT89C2051. Medical Equipment
Books
- Yang, X., Hu, W., Zhang, Y., Nokes, L. D. M., Wang, Y. F. and Liu, X. Q. 2012. A simple guide to analog electronic circuits, devices, and applications. Beijing: Publishing House of Electronic Industry.
- Yang, X., Zhang, Y. Q., Zhang, K. L., Nokes, L. D. M., Wang, Y. F. and Liu, X. Q. 2011. All you need to know about the 8051 microcontroller. Beijing: Publishing House of Electronic Industry.
- Yang, X., Nokes, L. D. M., Wang, Y. and Liu, X. 2010. Circuit design from the ground up (2nd edition). Beijing: Publishing House of Electronic Industry.
- Yang, X., Wang, Y. F., Liu, X. Q. and Zhang, Y. 2010. 8051 microcontroller: a project based introduction. Beijing: Tsinghua University Press.
- Yang, X., Wang, Z., Chen, X. and Wentling, C. 2009. Electronic components and circuit design in applications. Beijing: Electronic Industry Press.
- Yang, X., Wang, Y. F., Liu, X. Q. and Zhang, Y. 2008. 8051 Microcontroller: an application based introduction. Beijing: Tsinghua University Press.
- Yang, X., Wang, Y. F. and Liu, X. Q. 2006. Circuit design and simulation with Multisim 8 & Protel 2004. Beijing: Tsinghua University Press.
- Yang, X., Wang, Y. F. and Liu, X. Q. 2005. Circuit design from the ground up. 1st ed.. Beijing: Tsinghua University Press.
Conferences
- Alzamil, Y., Hicks, Y., Yang, X. and Marshall, C. 2018. Optimising graphical techniques applied to irreversible tracers. Presented at: 5th International Conference on Bioimaging, Optimising Graphical Techniques Applied to Irreversible Tracers, 19 - 21 January 2018.
- Li, J., Wu, F., Wang, H., Cuenca, J., Yang, X. and Barrow, D. 2017. An automated system for the shape optimization of double emulsion droplets used in the fabrication of Inertial Fusion Energy target shells. Presented at: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Cardiff, 22-26 October 2017.
- Al-Qahtani, M., Alwahiby, M., Abdelhamid, M., Mirza, E. H. and Yang, X. 2015. Wireless platform for real-time electrocardiography (ECG) recording and analysis. Presented at: 9th International Conference on Bioinformatics and Biomedical Engineering, ICBBE 2015;, Shanghai; China, 18 - 20 September 2015 Presented at Chou, J. ed.
- Abduljabar, A., Yang, X., Barrow, D. and Porch, A. 2015. Microstrip split ring resonator for microsphere detection and characterization. Presented at: 2015 IEEE MTT-S International Microwave Symposium, Phoenix, AZ, USA, 17-22 May 20152015 IEEE MTT-S International Microwave Symposium. pp. 1-4.
- Yang, X., Anderson, T., Moran, C. M., Hadoke, P., Gray, G. and Hopkins, P. 2012. Validation of velocity measurement of preclinical ultrasound. Presented at: Ultrasound 2012: 44th Annual Scientific Meeting of the British Medical Ultrasound Society, Telford, UK, 10 - 12 December 2012.
- Hollis, L., Yang, X., Adams, F., Khan, F. and Hoskins, P. R. 2012. Feasibility study for estimation of wall shear rate in flow mediated dilation. Presented at: 44th Annual Scientific Meeting of the British Medical Ultrasound Society, Telford, UK, 10-12 December, 2012.
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2011. Quantifying neovascularization in Achilles tendinopathy using 3D power Doppler ultrasound: the correlation between the clinical severity and the volume of neovascularization. Presented at: IPEM Conferences: The Physics & Technology of Medical Ultrasound, York, UK, 16 - 17 March 2011.
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. m. 2010. Quantifying neovascularization in Achilles tendinopathy. Presented at: All-Wales IPEM Scientific Conference, Cardiff, UK, 10 June 2010.
Research
Funded projects:
| 2025 | Yang X (PI), Clayton A (CoI) | EPSRC IAA | £19,774 | An ultrafast acoustic nanoparticle centrifuge to enrich dengue virus for large-scale dengue diagnosis |
|
2024-2025 |
Clayton A (PI), Yang X (CoI) |
Cancer Research UK |
£91,000 |
Acoustic Centrifugation to Enhance Extracellular Vesicle Based Prostate Cancer Diagnosis |
|
2017-2018 |
Yang X (PI) |
EPSRC First Grant |
£124,998 |
A lab-on-a-chip for characterising and sorting cancer cells |
|
2019-2022 |
Theobald P (PI) Yang X (CoI) Soe S (CoI) |
EPSRC |
£341,832 (Cardiff) £393,630 (Glasgow) |
Growth and Remodelling in the Porcine Heart-- Pushing Mathematics through Experiments |
|
2018-2020 |
Yang X (PI) |
The Royal Society International Exchanges |
£12,000 |
The Analysis of Mechanical Factors and Response in Tumour Microenvironment of Metastasis |
|
2019-2020 |
Eunju Shin (PI) Yang X (CoI) |
Wellcome Trust ISSF3 Cross Disciplinary Award |
£48,399 |
Using surface acoustic waves to efficiently generate pure neuronal populations from stem cells to generate insight into human brain disorders |
|
2020-2021 |
William Gray (PI) Yang X (CoI) |
EPSRC IAA |
£10,207 |
Developing an enhanced gel model to study device performance for cell and drug delivery to brain |
|
2019-2020 |
Yang X (PI) |
IREGene Pharmaceutics Ltd. |
£10,000 |
Development of Acoustofluidic Devices for Early Cancer Diagnostics |
|
2019 |
Yang X (PI) |
GCRF IAA |
£29,607 |
A smartphone-based acoustofluidic chip for point-of-care diagnosis of dengue virus in Malaysia |
|
2019 |
Yang X (PI) |
National Epitaxy Facility Pump Priming |
£2,000 |
Gallium Nitride for Nano and Microelectromechanical Systems (GaN N/MEMS) |
|
2019 |
Yang X (PI) Clayton A (CoI) |
GCRF |
£49,895 |
An Acoustic Microfluidic Chip for Malaria Detection and Treatment in India |
|
2019 |
Yang X (supervisor) Roman Mikhaylov |
EPSRC Industrial Strategy Innovation |
£10,971 |
Acoustofluidic separation of exosomes for precision medicine |
|
2018-2019 |
Clayton A (PI) Yang X (CoI) |
Wellcome Trust ISSF3 Cross Disciplinary Award |
£46,746 |
Using thermal acoustic waves to fractionate nanovesicle subpopulations for liquid biopsy utility |
|
2018 |
Yang X (PI) Clayton A (CoI) |
GCRF IAA |
£24,416 |
PCBSAW: A Printed Circuit Board Based Surface Acoustic Wave Biochip for Low Cost Early Cancer Diagnostics |
|
2018-2021 |
Yang X (PI) Clayton A (CoI) Xie Z (CoI) |
EPSRC DTP |
£65,000 |
Acoustic Separation of Cancer-derived Extracellular Vesicles for Cancer Early Diagnostics |
|
2018 |
Pagliara S (PI) McArdle C (CoI) Tosh D (CoI) Yang X (CoI) |
GW4 Building Communities Programme Initiator Fund |
£8,840 |
Microfluidics and modelling for investigating cellular heterogeneity |
|
2018-2019 |
Yang X (PI) Clayton A (CoI) Shen M (CoI) Evans W (CoI) |
EPSRC IAA |
£49,850 |
An Acoustic Chip for Separating Circulating Tumour Biomarkers for Cancer Diagnosis and Treatment Monitoring |
|
2017 |
Yang X (PI) Votruba M (CoI) |
Cardiff Institute of Tissue Engineering and Repair |
£1,520 |
Near-infrared light irradiation device for early treatment of retinal neurodegenerative conditions |
|
2017-2019 |
Yang X (PI) |
Cardiff Incoming Visiting Fellowship Scheme & International Collaboration Fund |
£9,725 |
Targeting metastasis-initiating cells to reduce Cancer mortality |
|
2017-2020 |
Yang X (PI) Shen M (CoI) |
EPSRC DTP |
£65,000 |
An Ultrasonic System-on-a-chip for Early Cancer Diagnosis |
|
2016-2017 |
Yang X (PI) Wells P (CoI) |
EPSRC IAA |
£6,681 |
An ultrasonic point-of-care sensor for circulating tumour cell detection |
|
2016 |
Yang X (PI), Hicks Y (CoI) Nokes L (CoI) McCarthy M (CoI) |
Globus Medical, Inc. |
£6,020 |
MRI Characterisation of the Lumbar Spine in Lower Trunk Rotation |
|
2016 |
Yang X (PI) |
Cardiff Institute of Tissue Engineering and Repair |
£1,995 |
Ultrasound-guided percutaneous laser ablation of ventricular septum in hypertrophic cardiomyopathy |
|
2015 |
Yang X (PI) |
Biogae Renewable Energy Co. Ltd. |
£5,287 |
Engineering solutions for the enhancement of methane content in biogas |
|
2014 |
Yang X (PI) Nokes L (CoI) |
Welsh Arthritis Research Network |
£5,000 |
The Anatomical Effects of Rotation on the Cervical and Lumbar Soine: An MRI Study |
|
2014 |
Yang X (PI) |
Wellcome Trust |
£2,000 |
Classification of leg swelling using ultrasound elastography |
|
2014 |
Yang X (PI) |
Welsh European Funding |
£1,000 |
Microwave Sensors for Cancer Detection |
PhD students:
|
Title |
Student |
Status |
Degree |
|
Acoustic Interactions with Cells |
Povilas Dumcius |
Current |
PhD |
|
Acoustic Investigation of the Mechanism of Cancer Metastasis |
Victory Akhimien |
Current |
PhD |
|
Lab-on-GaN for Manipulating Cancer Exosomes for Cancer Early Diagnostics |
Mercedes Stringer Martin |
Current |
PhD |
|
Numerical and Experimental Acoustic Microfluidics for Detection of Circulating Tumour Cells |
Hanlin Wang |
Current |
PhD |
|
The Development of Acoustofluidic Lab-on-a-chip for Early Cancer Detection |
Fangda Wu |
Current |
PhD |
|
The Development of Novel Acoustic Microfluidic Chip for Separating Cancer-derived Exosomes |
Roman Mikhaylov |
Current |
PhD |
|
Ultrasound Diagnostics of Vulnerable plaque |
Sarah Alithey |
Graduated |
PhD |
|
A Novel Technique in Detecting Cancers In 3d Imaging. |
Al Qazzaz Salma |
Current |
PhD |
|
Optimising the Quantitative Analysis in Functional Pet Brain Imaging. |
Alzamil Yasser Zamil Abdullah |
Current |
PhD |
|
Quantitative Assessment of The Efficacy Of Extracorporeal Shock Wave Therapy In The Management Of Achilles Tendinopathy. Specialisation - Medical Physics. |
Al Omairi Baida Ajeal Badir |
Graduated |
PhD |
|
A Robust Technique for Detecting Abdominal Aortic Calcification Using Dual Energy X-Ray Absorptiometry |
Karima M A Elmasri |
Current |
PhD |
|
Use Of High Frequency Techniques In Medical Diagnostics |
Ehtaiba Mabrouka Haiba A |
Graduated |
PhD |
Biography
Dr Xin Yang received his Bachelor's degree from Beijing Jiaotong University, China, in 2005, followed by a Master's degree from Queen Mary University of London in 2006. He earned his PhD in Medical Engineering from Cardiff University in 2011 and subsequently conducted postdoctoral research at the University of Edinburgh from 2011 to 2012.
In 2012, Dr Yang joined the School of Engineering at Cardiff University, where he led the Medical Ultrasound and Sensor Laboratory (MUSL). His research group focused on developing acoustofluidic technologies and devices for a wide range of biomedical applications, including early cancer diagnosis and treatment, biosample manipulation and concentration, acceleration of stem cell differentiation, drug delivery, and the integration of artificial intelligence in medical technologies.
Dr Yang has been the recipient of numerous research grants from prestigious funding bodies, including the Engineering and Physical Sciences Research Council (EPSRC), the Royal Society, the Global Challenges Research Fund (GCRF), the Wellcome Trust, and various industrial partners, with a total funding portfolio exceeding £1 million.
He has authored more than 50 peer-reviewed publications in leading journals such as Applied Physics Reviews, Small, Nano Letters, Biomaterials Research, Acta Biomaterialia, Analytica Chimica Acta, and Lab on a Chip, and contributed to eight book titles in the field.
Dr Yang is an active member of the EPSRC, MRC, and BBSRC expert review panels, a senior member of both the UK Organ-on-a-Chip Network and the UK Acoustofluidics Group, and serves on the EPSRC Peer Review College. He currently sits on the editorial boards of Frontiers in Mechanical Engineering and Nanotechnology and Precision Engineering.