![Chris Yang](https://profiles-cardiff.imgix.net/attachments/3954?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Overview
Dr Xin Yang is leading the Medical Ultrasound and Sensor Laboratory (MUSL) at School of Engineering, Cardiff University to develop novel technologies for cancer diagnosis and treatment, as well as healthcare technologies for other diseases. Two examples of ongoing research in Dr Yang's lab as follows, more can be found by clicking the Publications tag.
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1. Acoustic Bio-chips for Cancer Diagnosis and Treatment Globally, about 1 in 6 deaths is due to cancer, and more than 10 million deaths are caused by cancers each year. Cancer spreading, or metastasis, is responsible for about 90% of cancer deaths. Metastasis is a process that cancer cells from the primary tumour migrate to surrounding tissues and to distant organs to form spreading tumours (Fig. 1). Dr Yang’s lab has developed a novel biochip (Fig. 2) to capture the cancer cells that are travelling through the body for spreading cancers. The cancer cells are introduced into a micro-channel (blue pipes in Fig. 2) in which acoustic waves sent by a pair of interdigital transducers (yellow electrodes in Fig. 2) are producing a force on the cells. The force can push the cancer cells to a sheath channel to be collected. Clinician can trace the primary tumour and monitor treatment outcomes by analysing the collected cancer cells. 2. Acoustic Culturing Stem Cells Stem cells have been shown to improve the symptoms of patients with Parkinson’s and Alzheimer's Diseases. As shown in Fig. 3, patient skin or blood cells can be reprogrammed into induced pluripotent stem cells (iPSCs), which can differentiate into disease-relevant cell-types to faithfully study disease biology. In Dr Yang’s lab, acoustic culturing has been developed and applied in the differentiation, in order to mediate and control the process for personalised stem cell therapies. |
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The above two example projects are only the snapshot of the research in Dr Yang’s lab, there are a number of PhD students, postdocs and visiting academics in his lab working on a variety of cutting edge research, with the aim of developing innovative technologies to tackle cancer and other diseases.
Dr Yang welcomes PhD candidates from Engineering/Computer Science/Physics/Chemistry/Biology/Medicine to join the Medical Ultrasound and Sensor Laboratory to work on following areas:
- Cancer early diagnostics
- Cancer immunotherapy
- Stem cell therapy
- Lab-on-a-chip
- Acoustics
- Fluid mechanics
- Ultrasound
- Medical imaging
- Microfluidics
- Bio-sensors
- Medical electronics
- Medical Engineering
Publication
2024
- Zhang, X. et al. 2024. Surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) for pre‐cytopathological screening. Advanced Science 11(39), article number: 2403574. (10.1002/advs.202403574)
- Zhang, F. et al. 2024. Discovery of a novel AhR-CYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assay. Acta Pharmaceutica Sinica B (10.1016/j.apsb.2024.09.014)
- Yu, Y. et al. 2024. Acoustic wave-driven microdroplet enrichment for surface-enhanced Raman spectroscopy detection. Optics 5(4), pp. 364-377. (10.3390/opt5040027)
- Dong, J., Liang, D., Kabla, A. J., Chen, X. and Yang, X. 2024. A combination of acoustophoresis and thermophoresis for enriching nanoparticles. Physics of Fluids 36(9), article number: 92005. (10.1063/5.0222212)
- Zhang, J. et al. 2024. Flexible surface acoustic wave technology for enhancing transdermal drug delivery. Drug Delivery and Translational Research (10.1007/s13346-024-01682-y)
- Wu, Z. et al. 2024. Investigation of piezoelectric printing devices for oil-free and on-demand picolitre monodisperse droplet generation. Scientific Reports 14(1), article number: 17104. (10.1038/s41598-024-67849-2)
2023
- Wu, F. et al. 2023. Power-controlled acoustofluidic manipulation of microparticles. Ultrasonics 134, article number: 107087. (10.1016/j.ultras.2023.107087)
- Dumcius, P. et al. 2023. Dual-Wave Acoustofluidic Centrifuge for Ultrafast Concentration of Nanoparticles and Extracellular Vesicles. Small 19(35), article number: 2300390. (10.1002/smll.202300390)
- Wang, K. et al. 2023. Open source board based acoustofluidic transwells for reversible disruption of the blood–brain barrier for therapeutic delivery. Biomaterials Research 27(1), article number: 69. (10.1186/s40824-023-00406-6)
- Wang, H. et al. 2023. An enhanced tilted-angle acoustic tweezer for mechanical phenotyping of cancer cells. Analytica Chimica Acta 1255, article number: 341120. (10.1016/j.aca.2023.341120)
- Wu, Z. et al. 2023. Investigation of high-Q lithium niobate-based double ring resonator used in RF signal modulation. Applied Sciences 13(7), article number: 4648. (10.3390/app13074648)
- Stringer Martin, M. et al. 2023. Methodologies, technologies and strategies for acoustic streaming based Acoustofluidics. Applied Physics Reviews 10, article number: 11315.
- Wang, H. et al. 2023. Modelling hybrid acoustofluidic devices for enhancing nano- and micro-particle manipulation in microfluidics. Applied Acoustics 205, article number: 109258. (10.1016/j.apacoust.2023.109258)
2022
- Sun, C. et al. 2022. Acoustically accelerated neural differentiation of human embryonic stem cells. Acta Biomaterialia 151, pp. 333-345. (10.1016/j.actbio.2022.07.041)
- Liu, L., Zhou, J., Tan, K., Zhang, H., Yang, X., Duan, H. and Fu, Y. 2022. A simplified three-dimensional numerical simulation approach for surface acoustic wave tweezers. Ultrasonics 125, article number: 106797. (10.1016/j.ultras.2022.106797)
- Alqazzaz, S. et al. 2022. Combined features in region of interest for brain tumor segmentation. Journal of Digital Imaging 35, pp. 938-946. (10.1007/s10278-022-00602-1)
- Wu, Z. et al. 2022. Tunable electromagnetically induced transparent window of terahertz metamaterials and Its sensing performance. Applied Sciences 12(14), article number: 7057. (10.3390/app12147057)
- Zahertar, S., Torun, H., Sun, C., Markwell, C., Dong, Y., Yang, X. and Fu, Y. 2022. Flexible platform of acoustofluidics and metamaterials with decoupled resonant frequencies. Sensors 22(12), article number: 4344. (10.3390/s22124344)
2021
- Dong, J., Liang, D., Yang, X. and Sun, C. 2021. Influences of microparticle radius and microchannel height on SSAW-based acoustophoretic aggregation. Ultrasonics 117, article number: 106547. (10.1016/j.ultras.2021.106547)
- Ma, J., Liang, D., Yang, X., Wang, H., Wu, F., Sun, C. and Xiao, Y. 2021. Numerical study of acoustophoretic manipulation of particles in microfluidic channels. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 235(10), pp. 1163-1174. (10.1177/09544119211024775)
- Mikhaylov, R. et al. 2021. A reconfigurable and portable acoustofluidic system based on flexible printed circuit board for the manipulation of microspheres. Journal of Micromechanics and Microengineering 31(7), article number: 74003. (10.1088/1361-6439/ac0515)
- Wang, Y. et al. 2021. Flexible/bendable acoustofluidics based on thin-film surface acoustic waves on thin aluminum sheets. ACS Applied Materials and Interfaces 13(14), pp. 16978-16986. (10.1021/acsami.0c22576)
- Latham, J., Hicks, Y. A., Yang, X., Setchi, R. and Rainer, T. 2021. Stable automatic envelope estimation for noisy doppler ultrasound. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 68(3), pp. 465-481. (10.1109/TUFFC.2020.3011823)
- Wu, Z. et al. 2021. Simulation and analysis of microring electric field sensor based on a lithium niobate-on-insulator. Crystals 11(4), pp. 359-. (10.3390/cryst11040359)
- Zhang, Q., Wang, Y., Li, D., Yang, X., Xie, J. and Fu, Y. 2021. Bending behaviors of flexible acoustic wave devices under non-uniform elasto-plastic deformation. Applied Physics Letters 118(12), article number: 121601. (10.1063/5.0043550)
- Al-qazzaz, S., Sun, X., Yang, H., Yang, Y., Xu, R., Nokes, L. and Yang, X. 2021. Image classification-based brain tumour tissue segmentation. Multimedia Tools and Applications 80, pp. 993-1008. (10.1007/s11042-020-09661-4)
2020
- Sun, C. et al. 2020. Thin film gallium nitride (GaN) based acoustofluidic tweezer: modelling and microparticle manipulation. Ultrasonics 108, article number: 106202. (10.1016/j.ultras.2020.106202)
- Sun, C. et al. 2020. Gallium nitride: a versatile compound semiconductor as novel piezoelectric film for acoustic tweezer in manipulation of cancer cells. IEEE Transactions on Electron Devices 67(8), pp. 3355-3361. (10.1109/TED.2020.3002498)
- Mikhaylov, R. et al. 2020. Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip 20(10), pp. 1807-1814. (10.1039/C9LC01192G)
- Tao, R. et al. 2020. Hierarchical nanotexturing enables acoustofluidics on slippery yet sticky, flexible surfaces. Nano Letters 20(5), pp. 3263-3270. (10.1021/acs.nanolett.0c00005)
- Tao, R. et al. 2020. Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes. Lab on a Chip 20(5), pp. 1002-1011. (10.1039/C9LC01189G)
2019
- Tao, X. et al. 2019. 3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves. Sensors and Actuators B: Chemical 299, article number: 126991. (10.1016/j.snb.2019.126991)
- Alqazzaz, S., Sun, X., Yang, X. and Nokes, L. 2019. Automated brain tumor segmentation on multi-modal MR image using SegNet. Computational Visual Media 5(2), pp. 209-219. (10.1007/s41095-019-0139-y)
- Wu, Z. et al. 2019. Polymer-based device fabrication and applications using direct laser writing technology. Polymers 11(3), article number: 553. (10.3390/polym11030553)
2018
- Yu, J., Wu, Z., Yang, X., Han, X. and Zhao, M. 2018. Tilted fiber bragg grating sensor using chemical plating of a palladium membrane for the detection of hydrogen leakage. Sensors 18(12), pp. 4478. (10.3390/s18124478)
- Alzamil, Y., Hicks, Y., Yang, X. and Marshall, C. 2018. Optimising graphical techniques applied to irreversible tracers. Presented at: 5th International Conference on Bioimaging, Optimising Graphical Techniques Applied to Irreversible Tracers, 19 - 21 January 2018.
2017
- Li, J., Wu, F., Wang, H., Cuenca, J., Yang, X. and Barrow, D. 2017. An automated system for the shape optimization of double emulsion droplets used in the fabrication of Inertial Fusion Energy target shells. Presented at: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Cardiff, 22-26 October 2017.
2016
- Elmasri, K., Hicks, Y. A., Yang, X., Sun, X., Pettit, R. J. and Evans, W. 2016. Automatic detection and quantification of abdominal aortic calcification in dual energy X-ray absorptiometry. Procedia Computer Science 96, pp. 1011-1021. (10.1016/j.procs.2016.08.116)
2015
- Abduljabar, A. A., Yang, X., Barrow, D. A. and Porch, A. 2015. Modelling and measurements of the microwave dielectric properties of microspheres. IEEE Transactions on Microwave Theory and Techniques 63(12), pp. 4492-4500. (10.1109/TMTT.2015.2495247)
- Abduljabar, A., Yang, X., Barrow, D. and Porch, A. 2015. Microstrip split ring resonator for microsphere detection and characterization. Presented at: 2015 IEEE MTT-S International Microwave Symposium, Phoenix, AZ, USA, 17-22 May 20152015 IEEE MTT-S International Microwave Symposium. pp. 1-4.
- Al-Qahtani, M., Alwahiby, M., Abdelhamid, M., Mirza, E. H. and Yang, X. 2015. Wireless platform for real-time electrocardiography (ECG) recording and analysis. Presented at: 9th International Conference on Bioinformatics and Biomedical Engineering, ICBBE 2015;, Shanghai; China, 18 - 20 September 2015 Presented at Chou, J. ed.
2013
- Yang, X., Sun, C., Anderson, T., Moran, C. A., Hadoke, P. W. F., Gray, G. A. and Hoskins, P. R. 2013. Assessment of spectral doppler in preclinical ultrasound using a small-size rotating phantom. Ultrasound in Medicine & Biology 39(8), pp. 1491-1499. (10.1016/j.ultrasmedbio.2013.03.013)
- Yang, X., Hollis, L., Adams, F., Khan, F. and Hoskins, P. R. 2013. A fast method to estimate the wall shear stress waveform in arteries. Ultrasound 21(1), pp. 23-28. (10.1177/1742271X12473871)
2012
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2012. The volume of the neovascularity and its clinical implications in Achilles tendinopathy. Ultrasound in Medicine & Biology 38(11), pp. 1887-1895. (10.1016/j.ultrasmedbio.2012.07.002)
- Yang, X., Anderson, T., Moran, C. M., Hadoke, P., Gray, G. and Hopkins, P. 2012. Validation of velocity measurement of preclinical ultrasound. Presented at: Ultrasound 2012: 44th Annual Scientific Meeting of the British Medical Ultrasound Society, Telford, UK, 10 - 12 December 2012.
- Yang, X., Hu, W., Zhang, Y., Nokes, L. D. M., Wang, Y. F. and Liu, X. Q. 2012. A simple guide to analog electronic circuits, devices, and applications. Beijing: Publishing House of Electronic Industry.
- Hollis, L., Yang, X., Adams, F., Khan, F. and Hoskins, P. R. 2012. Feasibility study for estimation of wall shear rate in flow mediated dilation. Presented at: 44th Annual Scientific Meeting of the British Medical Ultrasound Society, Telford, UK, 10-12 December, 2012.
2011
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2011. A novel 3-D power Doppler ultrasound approach to the quantification of Achilles tendon neovascularity. Ultrasound in Medicine & Biology 37(7), pp. 1046-1055. (10.1016/j.ultrasmedbio.2011.04.008)
- Yang, X., Coleman, D. P., Pugh, N. D., Liu, W. and Nokes, L. D. M. 2011. Quantitative assessment of intra-vascular volume in human Achilles tendinopathy. Journal of Medical Engineering & Technology 35(3-4), pp. 172-178. (10.3109/03091902.2011.558170)
- Yang, X., Zhang, Y. Q., Zhang, K. L., Nokes, L. D. M., Wang, Y. F. and Liu, X. Q. 2011. All you need to know about the 8051 microcontroller. Beijing: Publishing House of Electronic Industry.
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2011. Quantifying neovascularization in Achilles tendinopathy using 3D power Doppler ultrasound: the correlation between the clinical severity and the volume of neovascularization. Presented at: IPEM Conferences: The Physics & Technology of Medical Ultrasound, York, UK, 16 - 17 March 2011.
2010
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. m. 2010. Quantifying neovascularization in Achilles tendinopathy. Presented at: All-Wales IPEM Scientific Conference, Cardiff, UK, 10 June 2010.
- Yang, X., Pugh, N. D., Coleman, D. P. and Nokes, L. D. M. 2010. Are Doppler studies a useful method of assessing neovascularization in human Achilles tendinopathy? A systematic review and suggestions for optimizing machine settings. Journal of Medical Engineering & Technology 35(7-8), pp. 365-372. (10.3109/03091902.2010.497892)
- Yang, X., Nokes, L. D. M., Wang, Y. and Liu, X. 2010. Circuit design from the ground up (2nd edition). Beijing: Publishing House of Electronic Industry.
- Yang, X., Wang, Y. F., Liu, X. Q. and Zhang, Y. 2010. 8051 microcontroller: a project based introduction. Beijing: Tsinghua University Press.
2009
- Yang, X., Wang, Z., Chen, X. and Wentling, C. 2009. Electronic components and circuit design in applications. Beijing: Electronic Industry Press.
2008
- Yang, X., Wang, Y. F., Liu, X. Q. and Zhang, Y. 2008. 8051 Microcontroller: an application based introduction. Beijing: Tsinghua University Press.
2006
- Yang, X., Wang, Y. F. and Liu, X. Q. 2006. Circuit design and simulation with Multisim 8 & Protel 2004. Beijing: Tsinghua University Press.
2005
- Yang, X. and Zhang, K. L. 2005. The research of finger pulse analysis system with AT89C2051. Medical Equipment
- Yang, X., Wang, Y. F. and Liu, X. Q. 2005. Circuit design from the ground up. 1st ed.. Beijing: Tsinghua University Press.
Cynadleddau
- Alzamil, Y., Hicks, Y., Yang, X. and Marshall, C. 2018. Optimising graphical techniques applied to irreversible tracers. Presented at: 5th International Conference on Bioimaging, Optimising Graphical Techniques Applied to Irreversible Tracers, 19 - 21 January 2018.
- Li, J., Wu, F., Wang, H., Cuenca, J., Yang, X. and Barrow, D. 2017. An automated system for the shape optimization of double emulsion droplets used in the fabrication of Inertial Fusion Energy target shells. Presented at: The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), Cardiff, 22-26 October 2017.
- Abduljabar, A., Yang, X., Barrow, D. and Porch, A. 2015. Microstrip split ring resonator for microsphere detection and characterization. Presented at: 2015 IEEE MTT-S International Microwave Symposium, Phoenix, AZ, USA, 17-22 May 20152015 IEEE MTT-S International Microwave Symposium. pp. 1-4.
- Al-Qahtani, M., Alwahiby, M., Abdelhamid, M., Mirza, E. H. and Yang, X. 2015. Wireless platform for real-time electrocardiography (ECG) recording and analysis. Presented at: 9th International Conference on Bioinformatics and Biomedical Engineering, ICBBE 2015;, Shanghai; China, 18 - 20 September 2015 Presented at Chou, J. ed.
- Yang, X., Anderson, T., Moran, C. M., Hadoke, P., Gray, G. and Hopkins, P. 2012. Validation of velocity measurement of preclinical ultrasound. Presented at: Ultrasound 2012: 44th Annual Scientific Meeting of the British Medical Ultrasound Society, Telford, UK, 10 - 12 December 2012.
- Hollis, L., Yang, X., Adams, F., Khan, F. and Hoskins, P. R. 2012. Feasibility study for estimation of wall shear rate in flow mediated dilation. Presented at: 44th Annual Scientific Meeting of the British Medical Ultrasound Society, Telford, UK, 10-12 December, 2012.
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2011. Quantifying neovascularization in Achilles tendinopathy using 3D power Doppler ultrasound: the correlation between the clinical severity and the volume of neovascularization. Presented at: IPEM Conferences: The Physics & Technology of Medical Ultrasound, York, UK, 16 - 17 March 2011.
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. m. 2010. Quantifying neovascularization in Achilles tendinopathy. Presented at: All-Wales IPEM Scientific Conference, Cardiff, UK, 10 June 2010.
Erthyglau
- Zhang, X. et al. 2024. Surface acoustic wave‐enhanced multi‐view acoustofluidic rotation cytometry (MARC) for pre‐cytopathological screening. Advanced Science 11(39), article number: 2403574. (10.1002/advs.202403574)
- Zhang, F. et al. 2024. Discovery of a novel AhR-CYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assay. Acta Pharmaceutica Sinica B (10.1016/j.apsb.2024.09.014)
- Yu, Y. et al. 2024. Acoustic wave-driven microdroplet enrichment for surface-enhanced Raman spectroscopy detection. Optics 5(4), pp. 364-377. (10.3390/opt5040027)
- Dong, J., Liang, D., Kabla, A. J., Chen, X. and Yang, X. 2024. A combination of acoustophoresis and thermophoresis for enriching nanoparticles. Physics of Fluids 36(9), article number: 92005. (10.1063/5.0222212)
- Zhang, J. et al. 2024. Flexible surface acoustic wave technology for enhancing transdermal drug delivery. Drug Delivery and Translational Research (10.1007/s13346-024-01682-y)
- Wu, Z. et al. 2024. Investigation of piezoelectric printing devices for oil-free and on-demand picolitre monodisperse droplet generation. Scientific Reports 14(1), article number: 17104. (10.1038/s41598-024-67849-2)
- Wu, F. et al. 2023. Power-controlled acoustofluidic manipulation of microparticles. Ultrasonics 134, article number: 107087. (10.1016/j.ultras.2023.107087)
- Dumcius, P. et al. 2023. Dual-Wave Acoustofluidic Centrifuge for Ultrafast Concentration of Nanoparticles and Extracellular Vesicles. Small 19(35), article number: 2300390. (10.1002/smll.202300390)
- Wang, K. et al. 2023. Open source board based acoustofluidic transwells for reversible disruption of the blood–brain barrier for therapeutic delivery. Biomaterials Research 27(1), article number: 69. (10.1186/s40824-023-00406-6)
- Wang, H. et al. 2023. An enhanced tilted-angle acoustic tweezer for mechanical phenotyping of cancer cells. Analytica Chimica Acta 1255, article number: 341120. (10.1016/j.aca.2023.341120)
- Wu, Z. et al. 2023. Investigation of high-Q lithium niobate-based double ring resonator used in RF signal modulation. Applied Sciences 13(7), article number: 4648. (10.3390/app13074648)
- Stringer Martin, M. et al. 2023. Methodologies, technologies and strategies for acoustic streaming based Acoustofluidics. Applied Physics Reviews 10, article number: 11315.
- Wang, H. et al. 2023. Modelling hybrid acoustofluidic devices for enhancing nano- and micro-particle manipulation in microfluidics. Applied Acoustics 205, article number: 109258. (10.1016/j.apacoust.2023.109258)
- Sun, C. et al. 2022. Acoustically accelerated neural differentiation of human embryonic stem cells. Acta Biomaterialia 151, pp. 333-345. (10.1016/j.actbio.2022.07.041)
- Liu, L., Zhou, J., Tan, K., Zhang, H., Yang, X., Duan, H. and Fu, Y. 2022. A simplified three-dimensional numerical simulation approach for surface acoustic wave tweezers. Ultrasonics 125, article number: 106797. (10.1016/j.ultras.2022.106797)
- Alqazzaz, S. et al. 2022. Combined features in region of interest for brain tumor segmentation. Journal of Digital Imaging 35, pp. 938-946. (10.1007/s10278-022-00602-1)
- Wu, Z. et al. 2022. Tunable electromagnetically induced transparent window of terahertz metamaterials and Its sensing performance. Applied Sciences 12(14), article number: 7057. (10.3390/app12147057)
- Zahertar, S., Torun, H., Sun, C., Markwell, C., Dong, Y., Yang, X. and Fu, Y. 2022. Flexible platform of acoustofluidics and metamaterials with decoupled resonant frequencies. Sensors 22(12), article number: 4344. (10.3390/s22124344)
- Dong, J., Liang, D., Yang, X. and Sun, C. 2021. Influences of microparticle radius and microchannel height on SSAW-based acoustophoretic aggregation. Ultrasonics 117, article number: 106547. (10.1016/j.ultras.2021.106547)
- Ma, J., Liang, D., Yang, X., Wang, H., Wu, F., Sun, C. and Xiao, Y. 2021. Numerical study of acoustophoretic manipulation of particles in microfluidic channels. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 235(10), pp. 1163-1174. (10.1177/09544119211024775)
- Mikhaylov, R. et al. 2021. A reconfigurable and portable acoustofluidic system based on flexible printed circuit board for the manipulation of microspheres. Journal of Micromechanics and Microengineering 31(7), article number: 74003. (10.1088/1361-6439/ac0515)
- Wang, Y. et al. 2021. Flexible/bendable acoustofluidics based on thin-film surface acoustic waves on thin aluminum sheets. ACS Applied Materials and Interfaces 13(14), pp. 16978-16986. (10.1021/acsami.0c22576)
- Latham, J., Hicks, Y. A., Yang, X., Setchi, R. and Rainer, T. 2021. Stable automatic envelope estimation for noisy doppler ultrasound. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 68(3), pp. 465-481. (10.1109/TUFFC.2020.3011823)
- Wu, Z. et al. 2021. Simulation and analysis of microring electric field sensor based on a lithium niobate-on-insulator. Crystals 11(4), pp. 359-. (10.3390/cryst11040359)
- Zhang, Q., Wang, Y., Li, D., Yang, X., Xie, J. and Fu, Y. 2021. Bending behaviors of flexible acoustic wave devices under non-uniform elasto-plastic deformation. Applied Physics Letters 118(12), article number: 121601. (10.1063/5.0043550)
- Al-qazzaz, S., Sun, X., Yang, H., Yang, Y., Xu, R., Nokes, L. and Yang, X. 2021. Image classification-based brain tumour tissue segmentation. Multimedia Tools and Applications 80, pp. 993-1008. (10.1007/s11042-020-09661-4)
- Sun, C. et al. 2020. Thin film gallium nitride (GaN) based acoustofluidic tweezer: modelling and microparticle manipulation. Ultrasonics 108, article number: 106202. (10.1016/j.ultras.2020.106202)
- Sun, C. et al. 2020. Gallium nitride: a versatile compound semiconductor as novel piezoelectric film for acoustic tweezer in manipulation of cancer cells. IEEE Transactions on Electron Devices 67(8), pp. 3355-3361. (10.1109/TED.2020.3002498)
- Mikhaylov, R. et al. 2020. Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip 20(10), pp. 1807-1814. (10.1039/C9LC01192G)
- Tao, R. et al. 2020. Hierarchical nanotexturing enables acoustofluidics on slippery yet sticky, flexible surfaces. Nano Letters 20(5), pp. 3263-3270. (10.1021/acs.nanolett.0c00005)
- Tao, R. et al. 2020. Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes. Lab on a Chip 20(5), pp. 1002-1011. (10.1039/C9LC01189G)
- Tao, X. et al. 2019. 3D patterning/manipulating microparticles and yeast cells using ZnO/Si thin film surface acoustic waves. Sensors and Actuators B: Chemical 299, article number: 126991. (10.1016/j.snb.2019.126991)
- Alqazzaz, S., Sun, X., Yang, X. and Nokes, L. 2019. Automated brain tumor segmentation on multi-modal MR image using SegNet. Computational Visual Media 5(2), pp. 209-219. (10.1007/s41095-019-0139-y)
- Wu, Z. et al. 2019. Polymer-based device fabrication and applications using direct laser writing technology. Polymers 11(3), article number: 553. (10.3390/polym11030553)
- Yu, J., Wu, Z., Yang, X., Han, X. and Zhao, M. 2018. Tilted fiber bragg grating sensor using chemical plating of a palladium membrane for the detection of hydrogen leakage. Sensors 18(12), pp. 4478. (10.3390/s18124478)
- Elmasri, K., Hicks, Y. A., Yang, X., Sun, X., Pettit, R. J. and Evans, W. 2016. Automatic detection and quantification of abdominal aortic calcification in dual energy X-ray absorptiometry. Procedia Computer Science 96, pp. 1011-1021. (10.1016/j.procs.2016.08.116)
- Abduljabar, A. A., Yang, X., Barrow, D. A. and Porch, A. 2015. Modelling and measurements of the microwave dielectric properties of microspheres. IEEE Transactions on Microwave Theory and Techniques 63(12), pp. 4492-4500. (10.1109/TMTT.2015.2495247)
- Yang, X., Sun, C., Anderson, T., Moran, C. A., Hadoke, P. W. F., Gray, G. A. and Hoskins, P. R. 2013. Assessment of spectral doppler in preclinical ultrasound using a small-size rotating phantom. Ultrasound in Medicine & Biology 39(8), pp. 1491-1499. (10.1016/j.ultrasmedbio.2013.03.013)
- Yang, X., Hollis, L., Adams, F., Khan, F. and Hoskins, P. R. 2013. A fast method to estimate the wall shear stress waveform in arteries. Ultrasound 21(1), pp. 23-28. (10.1177/1742271X12473871)
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2012. The volume of the neovascularity and its clinical implications in Achilles tendinopathy. Ultrasound in Medicine & Biology 38(11), pp. 1887-1895. (10.1016/j.ultrasmedbio.2012.07.002)
- Yang, X., Coleman, D. P., Pugh, N. D. and Nokes, L. D. M. 2011. A novel 3-D power Doppler ultrasound approach to the quantification of Achilles tendon neovascularity. Ultrasound in Medicine & Biology 37(7), pp. 1046-1055. (10.1016/j.ultrasmedbio.2011.04.008)
- Yang, X., Coleman, D. P., Pugh, N. D., Liu, W. and Nokes, L. D. M. 2011. Quantitative assessment of intra-vascular volume in human Achilles tendinopathy. Journal of Medical Engineering & Technology 35(3-4), pp. 172-178. (10.3109/03091902.2011.558170)
- Yang, X., Pugh, N. D., Coleman, D. P. and Nokes, L. D. M. 2010. Are Doppler studies a useful method of assessing neovascularization in human Achilles tendinopathy? A systematic review and suggestions for optimizing machine settings. Journal of Medical Engineering & Technology 35(7-8), pp. 365-372. (10.3109/03091902.2010.497892)
- Yang, X. and Zhang, K. L. 2005. The research of finger pulse analysis system with AT89C2051. Medical Equipment
Llyfrau
- Yang, X., Hu, W., Zhang, Y., Nokes, L. D. M., Wang, Y. F. and Liu, X. Q. 2012. A simple guide to analog electronic circuits, devices, and applications. Beijing: Publishing House of Electronic Industry.
- Yang, X., Zhang, Y. Q., Zhang, K. L., Nokes, L. D. M., Wang, Y. F. and Liu, X. Q. 2011. All you need to know about the 8051 microcontroller. Beijing: Publishing House of Electronic Industry.
- Yang, X., Nokes, L. D. M., Wang, Y. and Liu, X. 2010. Circuit design from the ground up (2nd edition). Beijing: Publishing House of Electronic Industry.
- Yang, X., Wang, Y. F., Liu, X. Q. and Zhang, Y. 2010. 8051 microcontroller: a project based introduction. Beijing: Tsinghua University Press.
- Yang, X., Wang, Z., Chen, X. and Wentling, C. 2009. Electronic components and circuit design in applications. Beijing: Electronic Industry Press.
- Yang, X., Wang, Y. F., Liu, X. Q. and Zhang, Y. 2008. 8051 Microcontroller: an application based introduction. Beijing: Tsinghua University Press.
- Yang, X., Wang, Y. F. and Liu, X. Q. 2006. Circuit design and simulation with Multisim 8 & Protel 2004. Beijing: Tsinghua University Press.
- Yang, X., Wang, Y. F. and Liu, X. Q. 2005. Circuit design from the ground up. 1st ed.. Beijing: Tsinghua University Press.
Research
Funded projects:
|
2017-2018 |
Yang X (PI) |
EPSRC First Grant |
£124,998 |
A lab-on-a-chip for characterising and sorting cancer cells |
|
2019-2022 |
Theobald P (PI) Yang X (CoI) Soe S (CoI) |
EPSRC |
£341,832 (Cardiff) £393,630 (Glasgow) |
Growth and Remodelling in the Porcine Heart-- Pushing Mathematics through Experiments |
|
2018-2020 |
Yang X (PI) |
The Royal Society International Exchanges |
£12,000 |
The Analysis of Mechanical Factors and Response in Tumour Microenvironment of Metastasis |
|
2019-2020 |
Eunju Shin (PI) Yang X (CoI) |
Wellcome Trust ISSF3 Cross Disciplinary Award |
£48,399 |
Using surface acoustic waves to efficiently generate pure neuronal populations from stem cells to generate insight into human brain disorders |
|
2020-2021 |
William Gray (PI) Yang X (CoI) |
EPSRC IAA |
£10,207 |
Developing an enhanced gel model to study device performance for cell and drug delivery to brain |
|
2019-2020 |
Yang X (PI) |
IREGene Pharmaceutics Ltd. |
£10,000 |
Development of Acoustofluidic Devices for Early Cancer Diagnostics |
|
2019 |
Yang X (PI) |
GCRF IAA |
£29,607 |
A smartphone-based acoustofluidic chip for point-of-care diagnosis of dengue virus in Malaysia |
|
2019 |
Yang X (PI) |
National Epitaxy Facility Pump Priming |
£2,000 |
Gallium Nitride for Nano and Microelectromechanical Systems (GaN N/MEMS) |
|
2019 |
Yang X (PI) Clayton A (CoI) |
GCRF |
£49,895 |
An Acoustic Microfluidic Chip for Malaria Detection and Treatment in India |
|
2019 |
Yang X (supervisor) Roman Mikhaylov |
EPSRC Industrial Strategy Innovation |
£10,971 |
Acoustofluidic separation of exosomes for precision medicine |
|
2018-2019 |
Clayton A (PI) Yang X (CoI) |
Wellcome Trust ISSF3 Cross Disciplinary Award |
£46,746 |
Using thermal acoustic waves to fractionate nanovesicle subpopulations for liquid biopsy utility |
|
2018 |
Yang X (PI) Clayton A (CoI) |
GCRF IAA |
£24,416 |
PCBSAW: A Printed Circuit Board Based Surface Acoustic Wave Biochip for Low Cost Early Cancer Diagnostics |
|
2018-2021 |
Yang X (PI) Clayton A (CoI) Xie Z (CoI) |
EPSRC DTP |
£65,000 |
Acoustic Separation of Cancer-derived Extracellular Vesicles for Cancer Early Diagnostics |
|
2018 |
Pagliara S (PI) McArdle C (CoI) Tosh D (CoI) Yang X (CoI) |
GW4 Building Communities Programme Initiator Fund |
£8,840 |
Microfluidics and modelling for investigating cellular heterogeneity |
|
2018-2019 |
Yang X (PI) Clayton A (CoI) Shen M (CoI) Evans W (CoI) |
EPSRC IAA |
£49,850 |
An Acoustic Chip for Separating Circulating Tumour Biomarkers for Cancer Diagnosis and Treatment Monitoring |
|
2017 |
Yang X (PI) Votruba M (CoI) |
Cardiff Institute of Tissue Engineering and Repair |
£1,520 |
Near-infrared light irradiation device for early treatment of retinal neurodegenerative conditions |
|
2017-2019 |
Yang X (PI) |
Cardiff Incoming Visiting Fellowship Scheme & International Collaboration Fund |
£9,725 |
Targeting metastasis-initiating cells to reduce Cancer mortality |
|
2017-2020 |
Yang X (PI) Shen M (CoI) |
EPSRC DTP |
£65,000 |
An Ultrasonic System-on-a-chip for Early Cancer Diagnosis |
|
2016-2017 |
Yang X (PI) Wells P (CoI) |
EPSRC IAA |
£6,681 |
An ultrasonic point-of-care sensor for circulating tumour cell detection |
|
2016 |
Yang X (PI), Hicks Y (CoI) Nokes L (CoI) McCarthy M (CoI) |
Globus Medical, Inc. |
£6,020 |
MRI Characterisation of the Lumbar Spine in Lower Trunk Rotation |
|
2016 |
Yang X (PI) |
Cardiff Institute of Tissue Engineering and Repair |
£1,995 |
Ultrasound-guided percutaneous laser ablation of ventricular septum in hypertrophic cardiomyopathy |
|
2015 |
Yang X (PI) |
Biogae Renewable Energy Co. Ltd. |
£5,287 |
Engineering solutions for the enhancement of methane content in biogas |
|
2014 |
Yang X (PI) Nokes L (CoI) |
Welsh Arthritis Research Network |
£5,000 |
The Anatomical Effects of Rotation on the Cervical and Lumbar Soine: An MRI Study |
|
2014 |
Yang X (PI) |
Wellcome Trust |
£2,000 |
Classification of leg swelling using ultrasound elastography |
|
2014 |
Yang X (PI) |
Welsh European Funding |
£1,000 |
Microwave Sensors for Cancer Detection |
PhD students:
|
Title |
Student |
Status |
Degree |
|
Acoustic Interactions with Cells |
Povilas Dumcius |
Current |
PhD |
|
Acoustic Investigation of the Mechanism of Cancer Metastasis |
Victory Akhimien |
Current |
PhD |
|
Lab-on-GaN for Manipulating Cancer Exosomes for Cancer Early Diagnostics |
Mercedes Stringer Martin |
Current |
PhD |
|
Numerical and Experimental Acoustic Microfluidics for Detection of Circulating Tumour Cells |
Hanlin Wang |
Current |
PhD |
|
The Development of Acoustofluidic Lab-on-a-chip for Early Cancer Detection |
Fangda Wu |
Current |
PhD |
|
The Development of Novel Acoustic Microfluidic Chip for Separating Cancer-derived Exosomes |
Roman Mikhaylov |
Current |
PhD |
|
Ultrasound Diagnostics of Vulnerable plaque |
Sarah Alithey |
Graduated |
PhD |
|
A Novel Technique in Detecting Cancers In 3d Imaging. |
Al Qazzaz Salma |
Current |
PhD |
|
Optimising the Quantitative Analysis in Functional Pet Brain Imaging. |
Alzamil Yasser Zamil Abdullah |
Current |
PhD |
|
Quantitative Assessment of The Efficacy Of Extracorporeal Shock Wave Therapy In The Management Of Achilles Tendinopathy. Specialisation - Medical Physics. |
Al Omairi Baida Ajeal Badir |
Graduated |
PhD |
|
A Robust Technique for Detecting Abdominal Aortic Calcification Using Dual Energy X-Ray Absorptiometry |
Karima M A Elmasri |
Current |
PhD |
|
Use Of High Frequency Techniques In Medical Diagnostics |
Ehtaiba Mabrouka Haiba A |
Graduated |
PhD |
Biography
Dr Xin Yang is currently holding the following roles in the school:
- Director of Medical Ultrasound and Sensors Laboratory (MUSL)
- Head of International, Department of Electrical and Electronic Engineering
- Coordinator of CU-HZAU iCDT on Biomedical and Bioenergy Engineering
- Postgraduate Research Admissions Tutor EEE
- Head of Healthy Living and Ageing Research Theme
Dr Yang is also an adjunct professor at Lanzhou Jiaotong University, China, and a member of the Peer Review College, EPSRC.
He graduated from Beijing Jiaotong University, China in 2005 with BEng of Biomedical Engineering, and then MSc in Medical Electronics & Physics from Queen Mary, University of London. Dr Yang was awarded a PhD in Medical Engineering from Cardiff University in 2011, on the research of Doppler ultrasound in neovascularisation quantification. He was the CEO of Beijing BJ Device Instrumentation Ltd. between 2007 and 2009. Dr Yang was the British Heart Foundation (BHF) Research Fellow at the Queen's Medical Research Institute, the University of Edinburgh, working on developing Doppler ultrasound techniques for pre- and clinical applications between 2011 and 2012.
Dr Yang started his current position in Cardiff University since 2013 and was awarded his EPSRC First Grant in 2016 on the subject of a lab-on-a-chip for characterising and sorting cancer cells. He has been awarded a number of research grants funded by the EPSRC, the Royal Society, GCRF, Wellcome Trust and industries, covering the research areas of point-of-care cancer diagnostics, medical ultrasound, acoustofluidics, tumour microenvironment, and microfluidics. His current research focus is to develop acoustofluidic techniques to diagnose/treat cancers and other diseases. He has published tens of refereed journal papers on the above subjects, and published eight books as the principal author in the subject of electronics and microcontrollers.
Supervisions
Current supervision
Sarah Allithey
Research student
Roman Mikhaylov
Research student
Hanlin Wang
Research student