Dr Lin Ye

Senior Lecturer

My research interest is to investigate the cancer cells orientated cross-talks with the extracellular matrix (ECM) and stroma cells during the cancer development, progression and metastases. The first group of molecules of my interest is bone morphogenetic proteins and their signalling. BMPs play diverse and critical roles in a vicious cycle between cancer cells and the local environment in both primary and secondary tumours, and also contribute to the tumour-associated angiogenesis. Following my PhD study of bone morphogenetic proteins (BMP) and their signalling in prostate cancer, I continue to explore the mechanism(s) of bone metastasis from prostate cancer and breast cancer, seek and develop therapeutic approach particularly by targeting BMPs signalling.

The second group of molecules which we focus are anthrax toxin receptor 1 (ANTXR1, also known as tumour endothelial marker 8, TEM-8) and anthrax toxin receptor 2 (ANTXR2, also known as capillary morphogenesis gene 2, CMG2). These two molecules are initially identified as markers or genes for the angiogenesis. Our recent studies have shown that aberrant expression and function of these two molecules in the disease progression of breast cancer and prostate cancer. As these two transmembrane proteins play an important role mediating adhesion and migration of cancer cells upon ECM, and also orchestrating the consequent interactions between cancer cells and micro-environment to enable tumour growth and dissemination.

Selected publications:

Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer. Ye L, Bokobza S, Li J, Moazzam M, Chen J, Mansel RE, Jiang WG, Cancer Sci, 2010, 101:2137-2144

Bone morphogenetic protein-10 suppresses the growth and aggressiveness of prostate cancer cells through a Smad independent pathway. Ye L, Kynaston H, Jiang WG, J Urol, 2009, 181:2749-2759

Bone morphogenetic protein-9 induces apoptosis in prostate cancer cells, the role of prostate apoptosis response-4. Ye L, Kynaston H, Jiang WG, Mol Cancer Res, 2008, 6:1594-1606

Endogenous bone morphogenetic protein-7 controls the motility of prostate cancer cells through regulation of bone morphogenetic protein antagonists. Ye L, Lewis-Russell JM, Kynaston H, Jiang WG, J Urol, 2007, 178:1086-1091

Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cells. Ye L, Lewis-Russell JM, Davies G, Sanders AJ, Kynaston H, Jiang WG, Int J Oncol, 2007, 30:521-529

Capillary morphogenesis gene 2 inhibits growth of breast cancer cells and is inversely correlated with the disease progression and prognosis. Ye L, Sun PH, Malik MF, Mason MD, Jiang WG. J Cancer Res Clin Oncol. 2014, 140:957-67.

Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells. Ye L, Sanders AJ, Sun PH, Mason MD, Jiang WG. Oncol Lett. 2014, 7(6):2149-2153.

Date
Type

2018

Zhao, H., Chen, G., Ye, L., Yu, H., Li, S. and Jiang, W. 2018. DOK7V1 influences the malignant phenotype of lung cancer cells through PI3K/AKT/mTOR and FAK/paxillin signaling pathways. International Journal of Oncology (10.3892/ijo.2018.4624)
Li, L., Cui, Y., Ye, L., Zhao, Z., Jiang, W. and Ji, J. 2018. Psoriasin overexpression confers drug resistance to cisplatin by activating ERK in gastric cancer. International Journal of Oncology 53(3), pp. 1171-1182. (10.3892/ijo.2018.4455)
Jia, J., Martin, T. A., Ye, L., Meng, L., Xia, N., Jiang, W. G. and Zhang, X. 2018. Fibroblast activation protein-α promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways. International Journal of Molecular Medicine 41(1), pp. 275-283. (10.3892/ijmm.2017.3224)
Owen, S., Zabkiewicz, C., Ye, L., Sanders, A., Gong, C. and Jiang, W. 2018. Key factors in breast cancer dissemination and establishment at the bone: past, present and future perspectives. In: Song, E. and Hu, H. eds. Translational Research in Breast Cancer:Biomarker Diagnosis, Targeted Therapies and Approaches to Precision., Vol. 1026. Advances in Experimental Medicine and Biology Singapore: Kluwer, pp. 197-216., (10.1007/978-981-10-6020-5_9)
Zhao, Y., Ye, L., Pinson, P., Tang, Y. and Lu, P. 2018. Correlation-constrained and sparsity-controlled vector autoregressive model for spatio-temporal wind power forecasting. IEEE Transactions on Power Systems 33(5), pp. 5029-5040. (10.1109/TPWRS.2018.2794450)
Riaz, S. K., Khan, J. S., Shah, S. T. A., Wang, F., Ye, L., Jiang, W. and Malik, M. F. A. 2018. Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer. Cell Communication and Signaling 16, article number: 3. (10.1186/s12964-017-0213-y)
Zhao, Y., Ye, L., Wang, W., Sun, H., Ju, Y. and Tang, Y. 2018. Data-driven correction approach to refine power curve of wind farm under wind curtailment. IEEE Transactions on Sustainable Energy 9(1), pp. 95-105. (10.1109/TSTE.2017.2717021)

2017

Zabkiewicz, C., Resaul, J., Hargest, R., Jiang, W. G. and Ye, L. 2017. Bone morphogenetic proteins, breast cancer, and bone metastases: striking the right balance. Endocrine-Related Cancer 24(10), pp. R349-R366. (10.1530/ERC-17-0139)
Cai, S., Cai, J., Jiang, W. G. and Ye, L. 2017. Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review). International Journal of Molecular Medicine 40(4), pp. 965-971. (10.3892/ijmm.2017.3093)
Zabkiewicz, C., Resaul, J., Hargest, R., Jiang, W. G. and Ye, L. 2017. Increased expression of follistatin in breast cancer reduces invasiveness and clinically correlates with better survival. Cancer Genomics and Proteomics 14(4), pp. 241-251. (10.21873/cgp.20035)
Zhao, Q. et al. 2017. Protein of vascular endothelial growth inhibitor 174 inhibits epithelial-mesenchymal transition in renal cell carcinoma in vivo. Anticancer Research 37(8), pp. 4269-4275. (10.21873/anticanres.11819)
Zhao, Z., Cheng, S., Zabkiewicz, C., Chen, J., Zhang, L., Ye, L. and Jiang, W. G. 2017. Reduced expression of RanBPM Is associated with poorer survival from lung cancer and increased proliferation and invasion of lung cancer cells in vitro. Anticancer Research 37(8), pp. 4389-4397. (10.21873/anticanres.11833)
Kiran Riaz, S. et al. 2017. Transcriptional profiling of sonic hedgehog in a prospective cohort of breast cancer in a Pakistani population. Anticancer Research 37(8), pp. 4449-4454. (10.21873/anticanres.11840)
Malik, M. F. A., Riaz, S. K., Waqar, S. H., Faq, F., Ye, L. and Jiang, W. G. 2017. Role of Plexin B1 in a breast cancer cohort of Pakistani patients and its contribution towards cancer metastasis as indicated by an in vitro model. Anticancer Research 37(8), pp. 4483-4488. (10.21873/anticanres.11844)
Rangaraj, A., Ye, L., Sanders, A., Price, P. E., Harding, K. G. and Jiang, W. G. 2017. Molecular and cellular impact of Psoriasin (S100A7) on the healing of human wounds. Experimental and Therapeutic Medicine 13(5), pp. 2151-2160. (10.3892/etm.2017.4275)
Chen, G. et al. 2017. The downstream of tyrosine kinase 7 is reduced in lung cancer and is associated with poor survival of patients with lung cancer. Oncology Reports 37(5), pp. 2695-2701. (10.3892/or.2017.5538)
Liu, Y. et al. 2017. Psoriasin promotes invasion, aggregation and survival of pancreatic cancer cells; association with disease progression. International Journal of Oncology 50(5), pp. 1491-1500. (10.3892/ijo.2017.3953)
Sun, P., Chen, G., Mason, M., Jiang, W. and Ye, L. 2017. Dual roles of protein tyrosine phosphatase kappa in coordinating angiogenesis induced by pro-angiogenic factors. International Journal of Oncology 50(4), pp. 1127-1135. (10.3892/ijo.2017.3884)
Cai, S. et al. 2017. Expression of phospholipase C isozymes in human breast cancer and their clinical significance. Oncology Reports 37(3), pp. 1707-1715. (10.3892/or.2017.5394)
Li, J. et al. 2017. Reduced NOV expression correlates with disease progression in colorectal cancer and is associated with survival, invasion and chemoresistance of cancer cells. Oncotarget (10.18632/oncotarget.15439)

2016

Shi, L., Resaul, J., Owen, S., Ye, L. and Jiang, W. 2016. Clinical and therapeutic implications of follistatin in solid tumours. Cancer Genomics and Proteomics 13(6), pp. 425-435.
Ye, L. and Jiang, W. G. 2016. Bone morphogenetic proteins in tumour associated angiogenesis and implication in cancer therapies. Cancer Letters 380(2), pp. 586-597. (10.1016/j.canlet.2015.10.036)
Li, J. et al. 2016. Differential expression of CCN family members CYR611, CTGF and NOV in gastric cancer and their association with disease progression. Oncology Reports (10.3892/or.2016.5074)
Liu, R., Martin, T. A., Jordan, N., Ruge, F., Ye, L. and Jiang, W. G. 2016. Epithelial protein lost in neoplasm-α (EPLIN-α) is a potential prognostic marker for the progression of epithelial ovarian cancer. International Journal of Oncology 48(6), pp. 2488-2496. (10.3892/ijo.2016.3462)
Jia, J., Ke, J., Ji, J., Hao, C., Ye, L., Sanders, A. J. and Jiang, W. 2016. IL24 and its receptors regulate growth and migration of pancreatic cancer cells and are potential biomarkers for IL24 molecular therapy. Anticancer Research 36(3), pp. 1153-1163.
Malik, M. F. A., Satherley, L., Davies, E., Ye, L. and Jiang, W. G. 2016. Expression of semaphorin 3C in breast cancer and its impact on adhesion and invasion of breast cancer cells. Anticancer Research 36(3), pp. 1281-1286.
Shao, S. et al. 2016. Reduced RanBPM expression is associated with distant metastasis in gastric cancer and chemoresistance. Anticancer Research 36(3), pp. 1295-1304.
Satherley, L., Sun, P. H., Ke, J., Mason, M. D., Hargest, R., Jiang, W. G. and Ye, L. 2016. Prostate Apoptosis Response-4 (PAR4) suppresses growth and invasion of breast cancer cells and is positively associated with patient survival. Anticancer Research 36(3), pp. 1227-1236.
Li, J. et al. 2016. Repulsive guidance molecule B inhibits metastasis and is associated with decreased mortality in non-small cell lung cancer. Oncotarget 7, pp. 15678-15689. (10.18632/oncotarget.7463)
Jiang, W. G. et al. 2016. Effects of YangZheng XiaoJi on the migration and growth of lung cancer cells, by targeting the Hepatocyte Growth Factor Receptor-Epidermal Growth Factor Receptor (HGFR-EGFR) transactivation [Abstract]. European Journal of Cancer 51(S3), pp. S642-S642., article number: 3117. (10.1016/S0959-8049(16)31758-0)
Wang, S., Ye, L., Sanders, A. J., Ruge, F., Harding, K. G. and Jiang, W. G. 2016. Tumour endothelial marker-8 in wound healing and its impact on the proliferation and migration of keratinocytes. International Journal of Molecular Medicine 37(2), pp. 293-298. (10.3892/ijmm.2015.2434)

2015

Li, J., Ye, L., Sun, P., Satherley, L., Hargest, R., Zhang, Z. and Jiang, W. G. 2015. MTA1 is up-regulated in colorectal cancer and is inversely correlated with lymphatic metastasis. Cancer Genomics and Proteomics 12(6), pp. 339-346.
Li, J., Ye, L., Owen, S., Weeks, H., Zhang, Z. and Jiang, W. G. 2015. Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). International Journal of Molecular Medicine 36(6), pp. 1451-1463. (10.3892/ijmm.2015.2390)
Liu, R., Martin, T. A., Jordan, N. J., Ruge, F., Ye, L. and Jiang, W. G. 2015. Metastasis suppressor 1 expression in human ovarian cancer: the impact on cellular migration and metastasis. International Journal of Oncology 47(4), pp. 1429-1439. (10.3892/ijo.2015.3121)
Gao, X. et al. 2015. Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: clinical implications. Oncology Reports 34(4), pp. 1977-1987. (10.3892/or.2015.4162)
Satherley, L., Ye, L., Hargest, R. and Jiang, W. G. 2015. Downstream of tyrosine kinase 7 (DOK7) variant expression and function in human colorectal cancer [Abstract]. European Journal of Cancer 51(S3), pp. S27. (10.1016/S0959-8049(15)30004-6)
Gao, X., Ji, K., Jia, Y., Li, J., Ji, J., Jiang, W. G. and Ye, L. 2015. Differential expression of CNN family members CYR61, CTGF and NOV in gastric cancer and association with disease progression [Abstract]. European Journal of Cancer 51(S3), pp. S404., article number: 2215. (10.1016/S0959-8049(16)31131-5)
Ye, L. et al. 2015. Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis (review). Oncology Letters 10(3), pp. 1240-1250. (10.3892/ol.2015.3459)
Jiang, W. G. et al. 2015. 3117 Effects of YangZheng XiaoJi on the migration and growth of lung cancer cells, by targeting the Hepatocyte Growth Factor Receptor-Epidermal Growth Factor Receptor (HGFR-EGFR) transactivation. European Journal of Cancer 51(Supp 1), pp. S642. (10.1016/S0959-8049(16)31758-0)
Jiang, W. G. et al. 2015. YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells. Journal of Translational Medicine 13, article number: 280. (10.1186/s12967-015-0639-1)
Malik, M., Ye, L. and Jiang, W. G. 2015. Reduced expression of semaphorin 4D and plexin-B in breast cancer is associated with poorer prognosis and the potential linkage with oestrogen receptor. Oncology Reports 34(2), pp. 1049-1057. (10.3892/or.2015.4015)
Liu, R., Jordan, N., Martin, T. A., Ruge, F., Ye, L. and Jiang, W. G. 2015. Metastasis suppressor 1 (MTSS1) expression in human ovarian cancer; the impact on cellular migration and metastasis [Abstract]. Anticancer Research 35(7), pp. 4342-4342.
Ye, L. et al. 2015. Kinase d-interacting substrate of 220 kda is over-expressed in gastric cancer and associated with local invasion. Anticancer Research 35(7), pp. 4338., article number: 112.
Liu, Y., Sun, P., Ye, L. and Jiang, W. G. 2015. Reduced expression of cancer-associated SM-like 1 in human breast cancer is associated with poor prognosis and its regulation of invasiveness of cancer cells. Anticancer Research 35(7), pp. 4324-4325., article number: 84.
Moazzam, M., Ye, L., Sun, P., Kynaston, H. and Jiang, W. G. 2015. Knockdown of WAVE3 impairs HGF induced migration and invasion of prostate cancer cells. Cancer Cell International 15, article number: 51. (10.1186/s12935-015-0203-3)
Wazir, U. et al. 2015. Effects of the knockdown of death-associated protein 3 expression on cell adhesion, growth and migration in breast cancer cells. Oncology Reports 33(5), pp. 2575-2582. (10.3892/or.2015.3825)
Jiang, W. et al. 2015. Expression of Sonic Hedgehog (SHH) in human lung cancer and the impact of YangZheng XiaoJi on SHH-mediated biological function of lung cancer cells and tumor growth.. Anticancer Research 35(3), pp. 1321-1331.

2014

Du, P., Ye, L., Yang, Y. and Jiang, W. G. 2014. Reduced expression of growth and differentiation factor-9 (GDF9) is associated with aggressive behaviour of human clear-cell renal cell carcinoma and poor patient survival.. Anticancer Research 34(11), pp. 6515-6520.
Ye, L., Sun, P., Sanders, A. J., Martin, T. A., Lane, J., Mason, M. D. and Jiang, W. G. 2014. Therapeutic potential of capillary morphogenesis gene 2 extracellular vWA domain in tumour-related angiogenesis. International Journal of Oncology 45(4), pp. 1565-1573. (10.3892/ijo.2014.2533)
Jiang, W. G. et al. 2014. The anti-peritoneal metastasis properties of Yangzheng Xiaoji, the potential role of hyaluronan and CD44 [Abstract]. Cancer Research 74(19), pp. 4034. (10.1158/1538-7445.AM2014-4034)
Sanders, A. J., Ye, L., Li, J., Mason, M. D. and Jiang, W. G. 2014. Tumour angiogenesis and repulsive guidance molecule b: A role in HGF- and BMP-7-mediated angiogenesis. International Journal of Oncology 45(3), pp. 1304-1312. (10.3892/ijo.2014.2508)
Bosanquet, D. C., Ye, L., Harding, K. G. and Jiang, W. G. 2014. FERM family proteins and their importance in cellular movements and wound healing [review]. International Journal of Molecular Medicine 34(1), pp. 3-12. (10.3892/ijmm.2014.1775)
Ye, L., Sanders, A. J., Sun, P., Mason, M. D. and Jiang, W. G. 2014. Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells. Onology Letters 7(6), pp. 2149-2153. (10.3892/ol.2014.2038)
Ye, L., Sun, P., Malik, M. F. A., Mason, M. D. and Jiang, W. G. 2014. Capillary morphogenesis gene 2 inhibits growth of breast cancer cells and is inversely correlated with the disease progression and prognosis. Journal of Cancer Research and Clinical Oncology 140(6), pp. 957-967. (10.1007/s00432-014-1650-2)
Satherley, L., Ye, L., Hargest, R. and Jiang, W. G. 2014. DOK7 expression in colorectal cancer cells and association with clinical and prognostic outcome [Abstract]. British Journal of Surgery 101(S4), pp. 12., article number: O34. (10.1002/bjs.9508)
Sun, T. T. et al. 2014. Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843(3), pp. 618-628. (10.1016/j.bbamcr.2013.12.013)
Ding, L., Ye, L., Xu, J. and Jiang, W. G. 2014. Impact of fibroblast activation protein on osteosarcoma cell lines in vitro. Oncology Letters 7(3), pp. 699-704. (10.3892/ol.2014.1788)
Malik, M. F. A., Ye, L. and Jiang, W. G. 2014. The plexin-B family and its role in cancer progression. Histology and Histopathology 29(2), pp. 151-165. (10.14670/HH-29.151)
Jia, Y., Ye, L., Ji, K., Zhang, L., Hargest, R., Ji, J. and Jiang, W. G. 2014. Death-associated protein-3, DAP-3, correlates with preoperative chemotherapy effectiveness and prognosis of gastric cancer patients following perioperative chemotherapy and radical gastrectomy. British Journal of Cancer 110(2), pp. 421-429. (10.1038/bjc.2013.712)
Jia, Y. et al. 2014. Death associated protein 1 is correlated with the clinical outcome of patients with colorectal cancer and has a role in the regulation of cell death. Oncology Reports 31(1), pp. 175-182. (10.3892/or.2013.2866)
Ji, K., Ye, L., Ruge, F., Hargest, R., Mason, M. D. and Jiang, W. G. 2014. Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer. BMC Cancer 14, article number: 723. (10.1186/1471-2407-14-723)
Jia, J., Martin, T. A., Ye, L. and Jiang, W. G. 2014. FAP-alpha (Fibroblast activation protein-alpha) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway. BMC Cell Biology 15, article number: 16. (10.1186/1471-2121-15-16)
Sasi, W., Ye, L., Jiang, W. G., Sharma, A. K. and Mokbel, K. 2014. In Vitro and In Vivo effects of suppressor of cytokine signalling 7 knockdown in breast cancer: the influence on cellular response to hepatocyte growth factor. BioMed Research International 2014, article number: 648040. (10.1155/2014/648040)

2013

Ye, L., Sun, P., Martin, T. A., Sanders, A. J., Mason, M. D. and Jiang, W. G. 2013. Psoriasin (S100A7) is a positive regulator of survival and invasion of prostate cancer cells. Urologic Oncology: Seminars and Original Investigations 31(8), pp. 1576-1583. (10.1016/j.urolonc.2012.05.006)
Sun, P., Ye, L., Mason, M. D. and Jiang, W. G. 2013. Receptor-like protein tyrosine phosphatase κ negatively regulates the apoptosis of prostate cancer cells via the JNK pathway. International Journal of Oncology 43(5), pp. 1560-1568. (10.3892/ijo.2013.2082)
Ji, K., Ye, L., Mason, M. D. and Jiang, W. G. 2013. The Kiss‑1/Kiss‑1R complex as a negative regulator of cell motility and cancer metastasis (Review). International Journal of Molecular Medicine 32(4), pp. 747-754. (10.3892/ijmm.2013.1472)
Jiang, W. G., Ye, L., Sanders, A. J., Ruge, F., Kynaston, H., Ablin, R. J. and Mason, M. D. 2013. Prostate transglutaminase (TGase-4, TGaseP) enhances the adhesion of prostate cancer cells to extracellular matrix, the potential role of TGase-core domain. Journal of Translational Medicine 11, article number: 269. (10.1186/1479-5876-11-269)
Jiang, W. G. et al. 2013. Antitumour effects of Yangzheng Xiaoji in human osteosarcoma: The pivotal role of focal adhesion kinase signalling. Oncology Reports 30(3), pp. 1405-1413. (10.3892/or.2013.2586)
Ye, L., Mason, M. D. and Jiang, W. G. 2013. Capillary morphogenesis gene 2 inhibits growth of breast cancer cells and is inversely correlated with the disease progression and prognosis [Abstract]. European Journal of Cancer 49, pp. S151-S151. (10.1016/S0959-8049(13)70060-1)
Owen, S., Sanders, A. J., Ye, L., Mason, M. D. and Jiang, W. G. 2013. Osteomodulin expression profile in human breast cancer [Abstract]. European Journal of Cancer 49, pp. S197-S197. (10.1016/S0959-8049(13)70061-3)
Sanders, A. J., Sobkowicz, A., Owen, S., Ye, L., Mason, M. D. and Jiang, W. G. 2013. A role for activated leukocyte cell adhesion molecule (ALCAM) in the growth and matrix adhesion of prostate cancer cells [Abstract]. European Journal of Cancer 49, pp. S685-S685.
Ye, L., Mason, M. D. and Jiang, W. G. 2013. Capillary morphogenesis gene 2 is a potential target for anti-angiogenic therapy [Abstract]. European Journal of Cancer 49, pp. S163-S164.
Jiang, W. et al. 2013. Inhibitory effect of Yangzheng Xiaoji on the ARK/Aurora pathways and in vivo tumour growth of human osteosarcoma. European Journal of Cancer 49(Supp 2), pp. S892.
Sun, P., Ye, L., Mason, M. D. and Jiang, W. 2013. Transmembrane Phosphatases and Cancer Development, the Role of Protein Tyrosine Phosphatase-kappa (PTPκ) and Protein Tyrosine Phosphatase-mu (PTPμ). Current Signal Transduction Therapy 8(2), pp. 129-141. (10.2174/15743624113086660003)
Bosanquet, D. C., Ye, L., Harding, K. G. and Jiang, W. 2013. Expressed in high metastatic cells (Ehm2) is a positive regulator of keratinocyte adhesion and motility: The implication for wound healing. Journal of Dermatological Science 71(2), pp. 115-121. (10.1016/j.jdermsci.2013.04.008)
Sun, P., Ye, L., Mason, M. D. and Jiang, W. G. 2013. Transmembrane phosphatases and cancer development, the role of Protein Tyrosine Phosphatase-kappa (PTP) and Protein Tyrosine Phosphatase-mu (PTP mu). Current Signal Transduction Therapy 8(2), pp. 129-141.
Sun, P., Ye, L., Mason, M. D. and Jiang, W. G. 2013. Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer. Journal of Cancer Research and Clinical Oncology 139(7), pp. 1129-1139. (10.1007/s00432-013-1421-5)
Xie, C. et al. 2013. CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer. Oncogene 32(18), pp. 2282-2291. (10.1038/onc.2012.251)
Frewer, N. et al. 2013. Potential implication of IL-24 in lymphangiogenesis of human breast cancer. International Journal of Molecular Medicine 31(5), pp. 1097-1104. (10.3892/ijmm.2013.1319)
Zhang, N. et al. 2013. Suppression of renal cell carcinoma growth in vivo by forced expression of vascular endothelial growth inhibitor. International Journal of Oncology 42(5), pp. 1664-1673. (10.3892/ijo.2013.1877)
Du, P., Ye, L., Yang, Y. and Jiang, W. G. 2013. Candidate of metastasis 1 regulates in vitro growth and invasion of bladder cancer cells. International Journal of Oncology 42(4), pp. 1249-1256. (10.3892/ijo.2013.1802)
Owen, S., Ye, L., Sanders, A., Mason, M. and Jiang, W. 2013. Expression profile of receptor activator of nuclear-kappa B (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) in breast cancer. Anticancer Research 33(1), pp. 199-206.
Zhang, N. et al. 2013. The differential expression of vascular endothelial growth inhibitor isoforms, VEGI251, VEGI174 and VEGI192 in human clear-cell renal cell carcinoma. Cancer Genomics and Proteomics 10(1), pp. 47-53.
Martin, T. A., Ye, L., Sanders, A. J., Lane, J. and Jiang, W. G. 2013. Cancer invasion and metastasis: molecular and cellular perspective. In: Jandial, R. ed. Metastatic Cancer Clinical and Biological Perspectives. Austin, TX: Landes Bioscience, pp. 135-168.
Ge, Z., Sanders, A. J., Ye, L., Mansel, R. E. and Jiang, W. G. 2013. Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro. Oncology Reports 29, pp. 1356-1364. (10.3892/or.2013.2259)

2012

Hu, M., Ye, L., Ruge, F., Zhi, X., Zhang, L. and Jiang, W. 2012. The clinical significance of Psoriasin for non-small cell lung cancer patients and its biological impact on lung cancer cell functions. BMC Cancer 12, article number: 588. (10.1186/1471-2407-12-588)
Sun, P., Ye, L., Mason, M. and Jiang, W. 2012. Protein tyrosine phosphatase µ (PTP µ or PTPRM), a negative regulator of proliferation and invasion of breast cancer cells, is associated with disease prognosis. Plos One 7(11), article number: e50183. (10.1371/journal.pone.0050183)
Jiang, W. G., Ye, L., Ji, K., Frewer, N., Ji, J. and Mason, M. D. 2012. Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway. International Journal of Oncology 41(5), pp. 1635-1642. (10.3892/ijo.2012.1627)
Du, P., Ye, L., Ruge, F., Yang, Y. and Jiang, W. G. 2012. Loss of expression of growth differentiation factor-9 (GDF9) in human kidney cancer and regulation of growth and migration of kidney cancer cells by GDF9. Anticancer Research 32(10), pp. 4375-4383.
Ji, K. et al. 2012. Expression of signal-induced proliferation-associated gene 1 (SIPA1), a rapGTPase-activating protein, is increased in colorectal cancer and has diverse effects on functions of colorectal cancer cells. Cancer Genomics and Proteomics 9(5), pp. 321-327.
Bosanquet, D. C., Ye, L., Saravolac, V., Sanders, A. J., Rangaraj, A., Harding, K. G. and Jiang, W. G. 2012. Ehm2 promotes wounds healing; the involvement of FAK and NWasp [Abstract]. Wound Repair and Regeneration 20(5), pp. A86. (10.1111/j.1524-475X.2012.00834.x)
Li, J., Ye, L., Sanders, A. J. and Jiang, W. G. 2012. Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling. Journal of Cellular Biochemistry 113(7), pp. 2523-2531. (10.1002/jcb.24128)
Ye, L., Ji, K., Frewer, N., Ji, J. and Jiang, W. G. 2012. Impact of Yangzheng Xiaoji on the adhesion and migration of human cancer cells: the role of the AKT signalling pathway. Anticancer Research 32(7), pp. 2537-2543.
Li, J., Ye, L. and Jiang, W. G. 2012. Repulsive guidance molecules (RGMs) and their potential implication in cancer as co-receptor of BMPs. Current Signal Transduction Therapy 7(2), pp. 149-460.
Du, P., Ye, L., Li, H., Ruge, F., Yang, Y. and Jiang, W. G. 2012. Growth differentiation factor-9 expression is inversely correlated with an aggressive behaviour in human bladder cancer cells. International Journal of Molecular Medicine 29(3), pp. 428-434. (10.3892/ijmm.2011.858)
Bosanquet, D., Ye, L., Harding, K. G. and Jiang, W. G. 2012. Role of HuR in keratinocyte migration and wound healing. Molecular Medicine Reports 5(2), pp. 529-534. (10.3892/mmr.2011.675)

2011

Sanders, A. J., Martin, T. A., Ye, L., Mason, M. D. and Jiang, W. G. 2011. EPLIN is a negative regulator of prostate cancer growth and invasion. The Journal of Urology 186(1), pp. 295-301. (10.1016/j.juro.2011.03.038)
Yuan, Z., Sanders, A. J., Ye, L., Wang, Y. and Jiang, W. G. 2011. Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9. Oncology Reports 26(1), pp. 237-245. (10.3892/or.2011.1271)
Rangaraj, A., Ye, L., Harding, K. G. and Jiang, W. G. 2011. Psoriasin (S100A7) gene and its functions in keratinocytes, the main cell types during wound healing [Abstract]. Wound Repair and Regeneration 19(2), pp. A45. (10.1111/j.1524-475X.2010.00670.x)
Rangaraj, A., Ye, L., Harding, K. G. and Jiang, W. G. 2011. BCL-2 interaction killer, BIK in keratinocyte cellular function and wound healing [Abstract]. Wound Repair and Regeneration 19(2), pp. A45. (10.1111/j.1524-475X.2010.00670.x)
Bosanquet, D. C., Ye, L., Saravolac, V., Sanders, A. J., Rangaraj, A., Harding, K. G. and Jiang, W. G. 2011. Keratinocyte migration, wound healing and the role of the novel protein EHM2 [Abstract]. Wound Repair and Regeneration 19(2), pp. A14. (10.1111/j.1524-475X.2010.00670.x)
Bosanquet, D. C., Ye, L., Saravolac, V., Sanders, A. J., Rangaraj, A., Harding, K. G. and Jiang, W. G. 2011. The role of HuR in keratinocyte migration and wound healing [Abstract]. Wound Repair and Regeneration 19(2), pp. A14. (10.1111/j.1524-475X.2010.00670.x)
Ye, L., Mason, M. D. and Jiang, W. G. 2011. Bone morphogenetic protein and bone metastasis, implication and therapeutic potential. Frontiers in Bioscience 16, pp. 865-897.
Yuan, Z., Sanders, A. J., Ye, L., Wang, Y. and Jiang, W. G. 2011. Prognostic value of the human antigen R (HuR) in human breast cancer: high level predicts a favourable prognosis. Anticancer Research 31(1), pp. 303-310.
Yu, H., Zhang, Y., Ye, L. and Jiang, W. G. 2011. The FERM family proteins in cancer invasion and metastasis. Frontiers in Bioscience 16(1), pp. 1536-1550. (10.2741/3803)
Li, J., Ye, L., Mansel, R. E. and Jiang, W. G. 2011. Potential prognostic value of repulsive guidance molecules in breast cancer.. Anticancer Research 31(5), pp. 1703-1711.
Du, P., Ye, L., Ruge, F., Yang, Y. and Jiang, W. G. 2011. Metastasis suppressor-1, MTSS1, acts as a putative tumour suppressor in human bladder cancer. Anticancer Research 31(10), pp. 3205-3212.
Ge, Z., Sanders, A. J., Ye, L. and Jiang, W. G. 2011. Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer. Experimental and Therapeutic Medicine 2(2), pp. 167-172. (10.3892/etm.2011.206)
Li, J., Ye, L., Kynaston, H. and Jiang, W. G. 2011. Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells. International Journal of Oncology 40(2), pp. 544-550. (10.3892/ijo.2011.1251)
Ge, Z., Sanders, A. J., Ye, L., Wang, Y. and Jiang, W. G. 2011. Expression of death decoy receptor-3 (DcR3) in human breast cancer and its functional effects on breast cancer cells in vitro. Journal of Experimental Therapeautics and Oncology 9, pp. 109-118. (10.3892/or.2013.2259)

2010

Sanders, A. J., Ye, L., Mason, M. D. and Jiang, W. G. 2010. The impact of EPLINα (Epithelial protein lost in neoplasm) on endothelial cells, angiogenesis and tumorigenesis. Angiogenesis 13(4), pp. 317-326. (10.1007/s10456-010-9188-7)
Cai, W., Ye, L., Sun, J., Mansel, R. E. and Jiang, W. G. 2010. Expression of MLN64 influences cellular matrix adhesion of breast cancer cells, the role for focal adhesion kinase. International Journal of Molecular Medicine 25(4), pp. 573-580. (10.3892/ijmm_00000379)
Ye, L., Chen, J., Xie, F., Yang, Y., Zhang, L. and Jiang, W. G. 2010. Expression of bone morphogenetic protein 7 in lung cancer and its biological impact on lung cancer cells. Anticancer Research 30(4), pp. 1113-1120.
Yu, H., Ye, L., Mansel, R. E., Zhang, Y. and Jiang, W. G. 2010. Clinical implications of the influence of Ehm2 on the aggressiveness of breast cancer cells through regulation of matrix metalloproteinase-9 expression. Molecular Cancer Research 8(11), pp. 1501-1512. (10.1158/1541-7786.MCR-10-0186)
Zhang, N., Sanders, A. J., Ye, L., Kynaston, H. and Jiang, W. 2010. Expression of vascular endothelial growth inhibitor (VEGI) in human urothelial cancer of the bladder and its effects on the adhesion and migration of bladder cancer cells in vitro. Anticancer Research 30(1), pp. 87-95.
Jiang, W. G., Ye, L., Ablin, R. J., Kynaston, H. and Mason, M. D. 2010. The prostate transglutaminase, TGase-4, coordinates with the HGFL/MSP-RON system in stimulating the migration of prostate cancer cells. International Journal of Oncology 37(2), pp. 413-418. (10.3892/ijo_00000689)
Rangaraj, A., Ye, L., Patel, G. K., Price, P. E., Harding, K. G. and Jiang, W. G. 2010. The molecular and cellular roles of Psoriasin (S100A4) in human cutaneous wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111/j.1524-475X.2010.00633.x)
Rangaraj, A., Ye, L., Patel, G. K., Harding, K. G. and Jiang, W. G. 2010. The role of Bik1 (BCL-2 interaction killer) in wound healing [Abstract]. Wound Repair and Regeneration 18(6), pp. A92. (10.1111/j.1524-475X.2010.00633.x)
Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins, in human wound tissues and the cellular impact of WAVEs on keratinocytes [Abstract]. Wound Repair and Regeneration 18(6), pp. A84. (10.1111/j.1524-475X.2010.00633.x)
Yuan, Z., Sanders, A. J., Ye, L. and Jiang, W. G. 2010. HuR, a key post-transcriptional regulator, and its implication in progression of breast cancer. Histology and Histopathology 25(10), pp. 1331-1340.
Bokobza, S. M., Ye, L., Kynaston, H. and Jiang, W. G. 2010. Growth and differentiation factor-9 promotes adhesive and motile capacity of prostate cancer cells by up-regulating FAK and Paxillin via Smad dependent pathway. Oncology Reports 24(6), pp. 1653-1659. (10.3892/or_00001030)
Bokobza, S. M., Ye, L., Kynaston, H. and Jiang, W. G. 2010. GDF-9 promotes the growth of prostate cancer cells by protecting them from apoptosis. Journal of Cellular Physiology 225(2), pp. 529-536. (10.1002/jcp.22235)
Bokobza, S. M., Ye, L., Kynaston, H. and Jiang, W. G. 2010. Growth and differentiation factor 9 (GDF-9) induces epithelial-mesenchymal transition in prostate cancer cells. Molecular and Cellular Biochemistry 349(1-2), pp. 33-40. (10.1007/s11010-010-0657-5)
Jiang, W. G., Ye, L., Patel, G. K. and Harding, K. G. 2010. Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues and the biological influence on human keratinocytes. Wound Repair and Regeneration 18(6), pp. 594-604. (10.1111/j.1524-475X.2010.00630.x)
Ye, L., Bokobza, S. M., Li, J., Moazzam, M., Chen, J., Mansel, R. E. and Jiang, W. 2010. Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer. Cancer Science 101(10), pp. 2137-2144. (10.1111/j.1349-7006.2010.01648.x)

2009

Zhang, N., Sanders, A. J., Ye, L., Kynaston, H. and Jiang, W. G. 2009. Vascular endothelial growth inhibitor, expression in human prostate cancer tissue and the impact on adhesion and migration of prostate cancer cells in vitro. International Journal of Oncology 35(6), pp. 1473-1480. (10.3892/ijo_00000466)
Ye, L., Bokobza, S. and Jiang, W. G. 2009. Bone morphogenetic proteins in development and progression of breast cancer and therapeutic potential (review). International Journal of Molecular Medicine 24(5), pp. 591-597. (10.3892/ijmm_00000269)
Zhang, N., Sanders, A. J., Ye, L. and Jiang, W. G. 2009. Vascular endothelial growth inhibitor in human cancer (Review). International Journal of Molecular Medicine 24(1), pp. 3-8. (10.3892/ijmm_00000198)
Ye, L., Kynaston, H. and Jiang, W. G. 2009. Bone Morphogenetic Protein-10 suppresses the growth and aggressiveness of prostate cancer cells through a Smad independent pathway. The Journal of Urology 181(6), pp. 2749-2759. (10.1016/j.juro.2009.01.098)
Bokobza, S. M., Ye, L., Kynaston, H., Mansel, R. E. and Jiang, W. G. 2009. Reduced expression of BMPR-IB correlates with poor prognosis and increased proliferation of breast cancer cells. Cancer Genomics and Proteomics 6(2), pp. 101-108.
Bokobza, S. M., Ye, L. and Jiang, W. G. 2009. When BMP signalling goes wrong: the intracellular and molecular mechanisms of BMP sgnalling in cancer. Current Signal Transduction Therapy 4(3), pp. 174-195. (10.2174/157436209789057485)
Noble, S. I. R., Parr, C., Ye, L., Zhang, L. and Jiang, W. G. 2009. The impact of metastasis tumour supressor-1 (MTSS1) on the metastatic characteristics of non small cell lung cancer and its association with smoking history [Abstract]. Journal of Thoracic Oncology 4(9), pp. S630. (10.1097/JTO.0b013e3181b9c77e)
Chen, J., Ye, L., Zhang, L. and Jiang, W. G. 2009. The molecular impact of pigment epithelium-derived factor, PEDF, on lung cancer cells and the clinical significance. International Journal of Oncology 35(1), pp. 159-166. (10.3892/ijo_00000324)

2008

Jiang, W. G., Martin, T. A., Lewis-Russell, J. M., Douglas-Jones, A. G., Ye, L. and Mansel, R. E. 2008. Eplin-alpha expression in human breast cancer, the impact on cellular migration and clinical outcome. Molecular Cancer 7, article number: 71. (10.1186/1476-4598-7-71)
Chen, J., Ye, L., Zhang, L. and Jiang, W. G. 2008. Placenta growth factor, PLGF, influences the motility of lung cancer cells, the role of Rho associated kinase, Rock1. Journal of Cellular Biochemistry 105(1), pp. 313-320. (10.1002/jcb.21831)
Ye, L., Lewis-Russell, J. M., Sanders, A. J., Kynaston, H. G. and Jiang, W. G. 2008. HGF/SF up-regulates the expression of bone morphogenetic protein 7 in prostate cancer cells. Urologic Oncology: Seminars and Original Investigations 26(2), pp. 190-197. (10.1016/j.urolonc.2007.03.027)
Davies, G., Martin, T. A., Ye, L., Lewis-Russell, J. M., Mason, M. D. and Jiang, W. G. 2008. Phospholipase-C gamma-1 (PLCγ-1) is critical in hepatocyte growth factor induced in vitro invasion and migration without affecting the growth of prostate cancer cells. Urologic Oncology: Seminars and Original Investigations 26(4), pp. 386-391. (10.1016/j.urolonc.2007.06.003)
Ye, L., Kynaston, H. and Jiang, W. G. 2008. Bone morphogenetic protein-9 induces apoptosis in prostate cancer cells, the role of prostate apoptosis response-4. Molecular Cancer Research 6(10), pp. 1594-1606. (10.1158/1541-7786.MCR-08-0171)
Ye, L. 2008. Bone morphogenetic proteins and their receptors in the development of bone metastasis in prostate cancer. PhD Thesis, Cardiff University.

2006

Jiang, W. G., Davies, G., Ye, L., Russell-Lewis, J., Mason, M. D. and Mansel, R. E. 2006. EPLIN (epithelial protein lost in neoplasm) affects matrix adhesion and cellular motility of breast cancer cells, the role of ezrin [Abstract]. Breast Cancer Research and Treatment 100, pp. S161-S161.

Education and qualifications

2004-2007: PhD, Cancer Biology, Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, UK
1993-1996: MSc, Master of Surgery, house officer at University Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China
1985-1993: MB and BCh, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China

Career overview

2013-present: Lecturer of Cancer Biology and Oncology, Cardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK
2007-2013: Posdoctoral Research Associate, Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, UK
1996-2004: Lecturer of Surgery and Registrar, Department of Surgery, University Hospital of Shandong University of TCM, Jinan, Shandong, China

Honours and awards

Merit Award from ASCO (American Society of Clinical Oncology) Prostate Symposium 2006, San Francisco, for the presentation entitled as ‘Expression of BMP7 is regulated by hepatocyte growth factor’.

Outstanding Research Award in 2002, from the State Department of Education, Shandong province, China, for the research project entitled as ‘Therapeutic Mechanisms of Regulating Vital Energy and Dispersing the Accumulation of Evils in Thyroid Benign Nodes Using Herbs’.

Annual Teaching Award in 2001, from the University Hospital, Shandong University of Traditional Chinese Medicine.

Award for Scientific Research in 1999, from the State Government, Shandong province, China, for the research project entitled as ‘Promoting Circulation Using Herbs, and the Application in Heart Attack’.

Professional memberships

Member of the British Association of Cancer Research (BACR)

Member of the European Association of Cancer Research (EACR)

Fellow of the Higher Education Academy, UK

Academic positions

2013-present: Lecturer of Cancer Biology and Oncology, Cardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK
2007-2013: Posdoctoral Research Associate, Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University School of Medicine, Cardiff, UK
1996-2004: Lecturer of Surgery and Registrar, Department of Surgery, University Hospital of Shandong University of TCM, Jinan, Shandong, China

Contact Details

YeL@cardiff.ac.uk
+44 29206 87861

Dr Lin Ye

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Dr Lin Ye

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2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2006

Articles

Book sections

Conferences

Thesis

Biography

Honours and awards

Professional memberships

Academic positions

Contact Details