Dr Kirsten Bentley
Timau a rolau for Kirsten Bentley
Cydymaith Ymchwil Ôl-ddoethurol
Trosolwyg
Rwy'n postdoc o fewn yr is-adran Heintiau ac Imiwnedd, ar hyn o bryd yn gweithio ar brosiectau sy'n gysylltiedig â SARS-CoV-2. Fy niddordebau ymchwil yw deall y mecanweithiau sylfaenol sy'n sail i ddyblygu firysau RNA llinyn cadarnhaol, yn enwedig y broses o ailgyfuno a sut mae'n cyfrannu at esblygiad firws.
Cyhoeddiad
2025
- Qerqez, A. N. et al., 2025. Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV. Cell Reports 44 (12) 116593. (10.1016/j.celrep.2025.116593)
- Bentley, K. et al. 2025. Virion proteomics of genetically intact HCMV reveals a regulator of envelope glycoprotein composition that protects against humoral immunity. Proceedings of the National Academy of Sciences 122 (38) e2425622122. (10.1073/pnas.2425622122)
- Sharma, P. et al. 2025. The pharmacokinetics of hexylresorcinol-containing lozenges and their antimicrobial efficacy against oral and respiratory microorganisms. Journal of Oral Microbiology 17 (1) 2525229. (10.1080/20002297.2025.2525229)
- Gao, Y. et al., 2025. Identification of soluble biomarkers that associate with distinct manifestations of long COVID. Nature Immunology 26 , pp.692–705. (10.1038/s41590-025-02135-5)
2024
- Wesgate, R. et al. 2024. Impact of artificial accelerated ageing of PVC surfaces and surface degradation on disinfectant efficacy. Journal of Hospital Infection 149 , pp.1-13. (10.1016/j.jhin.2023.12.021)
2023
- Duggan, K. et al. 2023. Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin. Journal of Hospital Infection (10.1016/j.jhin.2023.08.020)
- Grant, M. D. et al., 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8 (15) e170681. (10.1172/jci.insight.170681)
- Meredith, R. T. et al. 2023. Differential cellular and humoral immune responses in immunocompromised individuals following multiple SARS-CoV-2 vaccinations. Frontiers in Cellular and Infection Microbiology 13 (10.3389/fcimb.2023.1207313)
2022
- Dangi, T. et al., 2022. Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody. Journal of Clinical Investigation 132 (23) e162282. (10.1172/JCI162282)
- Scurr, M. J. et al. 2022. Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity. Nature Communications 13 5422. (10.1038/s41467-022-32985-8)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75 (1), pp.e82-e88. ciac170. (10.1093/cid/ciac170)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63 (6) 100208. (10.1016/j.jlr.2022.100208)
- Alnaji, F. G. et al., 2022. Generated randomly and selected functionally? The nature of enterovirus recombination. Viruses 14 (5) 916. (10.3390/v14050916)
2021
- Bentley, K. and Stanton, R. J. 2021. Hydroxypropyl methylcellulose-based nasal sprays effectively inhibit in vitro SARS-CoV-2 infection and spread. Viruses 13 (12) 2345. (10.3390/v13122345)
- Bentley, K. et al. 2021. Isolation and identification of inter-species Enterovirus recombinant genomes. Viruses 13 (12) 2390. (10.3390/v13122390)
- Bentley, K. et al. 2021. Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events. PLoS Pathogens 17 (8) e1009676. (10.1371/journal.ppat.1009676)
2020
- Keep, S. et al., 2020. Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus. Journal of General Virology 101 (10), pp.1103-1118. (10.1099/jgv.0.001474)
2019
- Herod, M. R. et al., 2019. The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication. Journal of General Virology 100 (9), pp.1293-1302. (10.1099/jgv.0.001283)
2018
- Bentley, K. et al. 2018. Structural and functional analysis of the roles of the HCV 5' NCR miR122-dependent long-range association and SLVI in genome translation and replication. PeerJ 6 e5870. (10.7717/peerj.5870)
- Bentley, K. and Evans, D. J. 2018. Mechanisms and consequences of positive-strand RNA virus recombination. Journal of General Virology 99 (10) 1345. (10.1099/jgv.0.001142)
2017
- Meng, B. et al., 2017. Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA. Virology Journal 14 (1) 138. (10.1186/s12985-017-0805-6)
2015
- Tuplin, A. et al., 2015. Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail. Nucleic Acids Research 43 (5), pp.2914-2926. (10.1093/nar/gkv142)
2013
- Bentley, K. , Armesto, M. and Britton, P. 2013. Infectious Bronchitis Virus as a Vector for the Expression of Heterologous Genes. PLoS ONE 8 (6), pp.e67875. (10.1371/journal.pone.0067875)
- Bentley, K. et al. 2013. Identification of a noncanonically transcribed subgenomic mRNA of infectious bronchitis virus and other gammacoronaviruses. Journal of Virology 87 (4), pp.2128-2136. (10.1128/JVI.02967-12)
2012
- Armesto, M. et al., Bridgen, A. ed. 2012. Coronavirus reverse genetics. [Reverse Genetics of RNA Viruses: Applications and Perspectives]. Wiley.
- Bentley, K. et al. 2012. Hydrogen peroxide vapour decontamination of surfaces artificially contaminated with norovirus surrogate feline calicivirus. Journal of Hospital Infection 80 (2), pp.116-121. (10.1016/j.jhin.2011.10.010)
Articles
- Qerqez, A. N. et al., 2025. Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV. Cell Reports 44 (12) 116593. (10.1016/j.celrep.2025.116593)
- Bentley, K. et al. 2025. Virion proteomics of genetically intact HCMV reveals a regulator of envelope glycoprotein composition that protects against humoral immunity. Proceedings of the National Academy of Sciences 122 (38) e2425622122. (10.1073/pnas.2425622122)
- Sharma, P. et al. 2025. The pharmacokinetics of hexylresorcinol-containing lozenges and their antimicrobial efficacy against oral and respiratory microorganisms. Journal of Oral Microbiology 17 (1) 2525229. (10.1080/20002297.2025.2525229)
- Gao, Y. et al., 2025. Identification of soluble biomarkers that associate with distinct manifestations of long COVID. Nature Immunology 26 , pp.692–705. (10.1038/s41590-025-02135-5)
- Wesgate, R. et al. 2024. Impact of artificial accelerated ageing of PVC surfaces and surface degradation on disinfectant efficacy. Journal of Hospital Infection 149 , pp.1-13. (10.1016/j.jhin.2023.12.021)
- Duggan, K. et al. 2023. Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin. Journal of Hospital Infection (10.1016/j.jhin.2023.08.020)
- Grant, M. D. et al., 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8 (15) e170681. (10.1172/jci.insight.170681)
- Meredith, R. T. et al. 2023. Differential cellular and humoral immune responses in immunocompromised individuals following multiple SARS-CoV-2 vaccinations. Frontiers in Cellular and Infection Microbiology 13 (10.3389/fcimb.2023.1207313)
- Dangi, T. et al., 2022. Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody. Journal of Clinical Investigation 132 (23) e162282. (10.1172/JCI162282)
- Scurr, M. J. et al. 2022. Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity. Nature Communications 13 5422. (10.1038/s41467-022-32985-8)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75 (1), pp.e82-e88. ciac170. (10.1093/cid/ciac170)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63 (6) 100208. (10.1016/j.jlr.2022.100208)
- Alnaji, F. G. et al., 2022. Generated randomly and selected functionally? The nature of enterovirus recombination. Viruses 14 (5) 916. (10.3390/v14050916)
- Bentley, K. and Stanton, R. J. 2021. Hydroxypropyl methylcellulose-based nasal sprays effectively inhibit in vitro SARS-CoV-2 infection and spread. Viruses 13 (12) 2345. (10.3390/v13122345)
- Bentley, K. et al. 2021. Isolation and identification of inter-species Enterovirus recombinant genomes. Viruses 13 (12) 2390. (10.3390/v13122390)
- Bentley, K. et al. 2021. Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events. PLoS Pathogens 17 (8) e1009676. (10.1371/journal.ppat.1009676)
- Keep, S. et al., 2020. Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus. Journal of General Virology 101 (10), pp.1103-1118. (10.1099/jgv.0.001474)
- Herod, M. R. et al., 2019. The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication. Journal of General Virology 100 (9), pp.1293-1302. (10.1099/jgv.0.001283)
- Bentley, K. et al. 2018. Structural and functional analysis of the roles of the HCV 5' NCR miR122-dependent long-range association and SLVI in genome translation and replication. PeerJ 6 e5870. (10.7717/peerj.5870)
- Bentley, K. and Evans, D. J. 2018. Mechanisms and consequences of positive-strand RNA virus recombination. Journal of General Virology 99 (10) 1345. (10.1099/jgv.0.001142)
- Meng, B. et al., 2017. Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA. Virology Journal 14 (1) 138. (10.1186/s12985-017-0805-6)
- Tuplin, A. et al., 2015. Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail. Nucleic Acids Research 43 (5), pp.2914-2926. (10.1093/nar/gkv142)
- Bentley, K. , Armesto, M. and Britton, P. 2013. Infectious Bronchitis Virus as a Vector for the Expression of Heterologous Genes. PLoS ONE 8 (6), pp.e67875. (10.1371/journal.pone.0067875)
- Bentley, K. et al. 2013. Identification of a noncanonically transcribed subgenomic mRNA of infectious bronchitis virus and other gammacoronaviruses. Journal of Virology 87 (4), pp.2128-2136. (10.1128/JVI.02967-12)
- Bentley, K. et al. 2012. Hydrogen peroxide vapour decontamination of surfaces artificially contaminated with norovirus surrogate feline calicivirus. Journal of Hospital Infection 80 (2), pp.116-121. (10.1016/j.jhin.2011.10.010)
Books
- Armesto, M. et al., Bridgen, A. ed. 2012. Coronavirus reverse genetics. [Reverse Genetics of RNA Viruses: Applications and Perspectives]. Wiley.
Bywgraffiad
2021-presennol: Ymchwilydd ôl-ddoethurol, Prifysgol Caerdydd, Ysgol Meddygaeth
2015-2020: ymchwilydd ôl-ddoethurol, Prifysgol St Andrews, Ysgol Bioleg
2013-2015: ymchwilydd ôl-ddoethurol, Prifysgol Warwick, Ysgol Bioleg
2006-2008: Gwyddonydd Ymchwil, Iechyd Cyhoeddus Lloegr, Porton Down
Addysg:
2008-2012: Firoleg PhD, Sefydliad Pirbright/Prifysgol Warwick
2005-2006: MSc Bioleg Foleciwlaidd a Patholeg Firysau: Coleg Imperial Llundain.
1999-2002: BSc (Anrh) Microbioleg a Firoleg, Prifysgol Warwick
Aelodaethau proffesiynol
Cymdeithas Microbioleg
Contact Details
Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ystafell 3F08, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN