Overview
I'm a postdoc within the division of Infection & Immunity, currently working on projects related to SARS-CoV-2. My research interests lie in understanding the fundamental mechanisms underlying the replication of positive-strand RNA viruses, particularly the process of recombination and how it contributes to virus evolution.
Publication
2024
- Wesgate, R. et al. 2024. Impact of artificial accelerated ageing of PVC surfaces and surface degradation on disinfectant efficacy. Journal of Hospital Infection 149, pp. 1-13. (10.1016/j.jhin.2023.12.021)
2023
- Duggan, K., Bentley, K., Stanton, R. J. and Maillard, J. 2023. Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin. Journal of Hospital Infection (10.1016/j.jhin.2023.08.020)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Meredith, R. T. et al. 2023. Differential cellular and humoral immune responses in immunocompromised individuals following multiple SARS-CoV-2 vaccinations. Frontiers in Cellular and Infection Microbiology 13 (10.3389/fcimb.2023.1207313)
2022
- Dangi, T. et al. 2022. Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody. Journal of Clinical Investigation 132(23), article number: e162282. (10.1172/JCI162282)
- Scurr, M. J. et al. 2022. Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity. Nature Communications 13, article number: 5422. (10.1038/s41467-022-32985-8)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75(1), pp. e82-e88., article number: ciac170. (10.1093/cid/ciac170)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Alnaji, F. G. et al. 2022. Generated randomly and selected functionally? The nature of enterovirus recombination. Viruses 14(5), article number: 916. (10.3390/v14050916)
2021
- Bentley, K. et al. 2021. Isolation and identification of inter-species Enterovirus recombinant genomes. Viruses 13(12), article number: 2390. (10.3390/v13122390)
- Bentley, K. and Stanton, R. J. 2021. Hydroxypropyl methylcellulose-based nasal sprays effectively inhibit in vitro SARS-CoV-2 infection and spread. Viruses 13(12), article number: 2345. (10.3390/v13122345)
- Bentley, K., Alnaji, F. G., Woodford, L., Jones, S., Woodman, A. and Evans, D. J. 2021. Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events. PLoS Pathogens 17(8), article number: e1009676. (10.1371/journal.ppat.1009676)
2020
- Keep, S. et al. 2020. Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus. Journal of General Virology 101(10), pp. 1103-1118. (10.1099/jgv.0.001474)
2019
- Herod, M. R., Adeyemi, O. O., Ward, J., Bentley, K., Harris, M., Stonehouse, N. J. and Polyak, S. J. 2019. The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication. Journal of General Virology 100(9), pp. 1293-1302. (10.1099/jgv.0.001283)
2018
- Bentley, K., Cook, J. P., Tuplin, A. K. and Evans, D. J. 2018. Structural and functional analysis of the roles of the HCV 5' NCR miR122-dependent long-range association and SLVI in genome translation and replication. PeerJ 6, article number: e5870. (10.7717/peerj.5870)
- Bentley, K. and Evans, D. J. 2018. Mechanisms and consequences of positive-strand RNA virus recombination. Journal of General Virology 99(10), article number: 1345. (10.1099/jgv.0.001142)
2017
- Meng, B., Bentley, K., Marriott, A. C., Scott, P. D., Dimmock, N. J. and Easton, A. J. 2017. Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA. Virology Journal 14(1), article number: 138. (10.1186/s12985-017-0805-6)
2015
- Tuplin, A., Struthers, M., Cook, J., Bentley, K. and Evans, D. J. 2015. Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail. Nucleic Acids Research 43(5), pp. 2914-2926. (10.1093/nar/gkv142)
2013
- Bentley, K., Armesto, M. and Britton, P. 2013. Infectious Bronchitis Virus as a Vector for the Expression of Heterologous Genes. PLoS ONE 8(6), pp. e67875. (10.1371/journal.pone.0067875)
- Bentley, K., Keep, S. M., Armesto, M. and Britton, P. 2013. Identification of a noncanonically transcribed subgenomic mRNA of infectious bronchitis virus and other gammacoronaviruses. Journal of Virology 87(4), pp. 2128-2136. (10.1128/JVI.02967-12)
2012
- Armesto, M., Bentley, K., Bickerton, E., Keep, S. and Britton, P. Bridgen, A. ed. 2012. Coronavirus reverse genetics. [Reverse Genetics of RNA Viruses: Applications and Perspectives]. Wiley.
- Bentley, K., Dove, B. K., Parks, S. R., Walker, J. T. and Bennett, A. M. 2012. Hydrogen peroxide vapour decontamination of surfaces artificially contaminated with norovirus surrogate feline calicivirus. Journal of Hospital Infection 80(2), pp. 116-121. (10.1016/j.jhin.2011.10.010)
Articles
- Wesgate, R. et al. 2024. Impact of artificial accelerated ageing of PVC surfaces and surface degradation on disinfectant efficacy. Journal of Hospital Infection 149, pp. 1-13. (10.1016/j.jhin.2023.12.021)
- Duggan, K., Bentley, K., Stanton, R. J. and Maillard, J. 2023. Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin. Journal of Hospital Infection (10.1016/j.jhin.2023.08.020)
- Grant, M. D. et al. 2023. Combined anti-S1 and anti-S2 antibodies from hybrid immunity elicit potent cross-variant ADCC against SARS-CoV-2. JCI Insight 8(15), article number: e170681. (10.1172/jci.insight.170681)
- Meredith, R. T. et al. 2023. Differential cellular and humoral immune responses in immunocompromised individuals following multiple SARS-CoV-2 vaccinations. Frontiers in Cellular and Infection Microbiology 13 (10.3389/fcimb.2023.1207313)
- Dangi, T. et al. 2022. Improved control of SARS-CoV-2 by treatment with nucleocapsid-specific monoclonal antibody. Journal of Clinical Investigation 132(23), article number: e162282. (10.1172/JCI162282)
- Scurr, M. J. et al. 2022. Magnitude of venous or capillary blood-derived SARS-CoV-2-specific T cell response determines COVID-19 immunity. Nature Communications 13, article number: 5422. (10.1038/s41467-022-32985-8)
- Saud, Z. et al. 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75(1), pp. e82-e88., article number: ciac170. (10.1093/cid/ciac170)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Alnaji, F. G. et al. 2022. Generated randomly and selected functionally? The nature of enterovirus recombination. Viruses 14(5), article number: 916. (10.3390/v14050916)
- Bentley, K. et al. 2021. Isolation and identification of inter-species Enterovirus recombinant genomes. Viruses 13(12), article number: 2390. (10.3390/v13122390)
- Bentley, K. and Stanton, R. J. 2021. Hydroxypropyl methylcellulose-based nasal sprays effectively inhibit in vitro SARS-CoV-2 infection and spread. Viruses 13(12), article number: 2345. (10.3390/v13122345)
- Bentley, K., Alnaji, F. G., Woodford, L., Jones, S., Woodman, A. and Evans, D. J. 2021. Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events. PLoS Pathogens 17(8), article number: e1009676. (10.1371/journal.ppat.1009676)
- Keep, S. et al. 2020. Multiple novel non-canonically transcribed sub-genomic mRNAs produced by avian coronavirus infectious bronchitis virus. Journal of General Virology 101(10), pp. 1103-1118. (10.1099/jgv.0.001474)
- Herod, M. R., Adeyemi, O. O., Ward, J., Bentley, K., Harris, M., Stonehouse, N. J. and Polyak, S. J. 2019. The broad-spectrum antiviral drug arbidol inhibits foot-and-mouth disease virus genome replication. Journal of General Virology 100(9), pp. 1293-1302. (10.1099/jgv.0.001283)
- Bentley, K., Cook, J. P., Tuplin, A. K. and Evans, D. J. 2018. Structural and functional analysis of the roles of the HCV 5' NCR miR122-dependent long-range association and SLVI in genome translation and replication. PeerJ 6, article number: e5870. (10.7717/peerj.5870)
- Bentley, K. and Evans, D. J. 2018. Mechanisms and consequences of positive-strand RNA virus recombination. Journal of General Virology 99(10), article number: 1345. (10.1099/jgv.0.001142)
- Meng, B., Bentley, K., Marriott, A. C., Scott, P. D., Dimmock, N. J. and Easton, A. J. 2017. Unexpected complexity in the interference activity of a cloned influenza defective interfering RNA. Virology Journal 14(1), article number: 138. (10.1186/s12985-017-0805-6)
- Tuplin, A., Struthers, M., Cook, J., Bentley, K. and Evans, D. J. 2015. Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail. Nucleic Acids Research 43(5), pp. 2914-2926. (10.1093/nar/gkv142)
- Bentley, K., Armesto, M. and Britton, P. 2013. Infectious Bronchitis Virus as a Vector for the Expression of Heterologous Genes. PLoS ONE 8(6), pp. e67875. (10.1371/journal.pone.0067875)
- Bentley, K., Keep, S. M., Armesto, M. and Britton, P. 2013. Identification of a noncanonically transcribed subgenomic mRNA of infectious bronchitis virus and other gammacoronaviruses. Journal of Virology 87(4), pp. 2128-2136. (10.1128/JVI.02967-12)
- Bentley, K., Dove, B. K., Parks, S. R., Walker, J. T. and Bennett, A. M. 2012. Hydrogen peroxide vapour decontamination of surfaces artificially contaminated with norovirus surrogate feline calicivirus. Journal of Hospital Infection 80(2), pp. 116-121. (10.1016/j.jhin.2011.10.010)
Books
- Armesto, M., Bentley, K., Bickerton, E., Keep, S. and Britton, P. Bridgen, A. ed. 2012. Coronavirus reverse genetics. [Reverse Genetics of RNA Viruses: Applications and Perspectives]. Wiley.
Biography
2021-present: Post-doctoral researcher, Cardiff University, School of Medicine
2015-2020: Post-doctoral researcher, University of St Andrews, School of Biology
2013-2015: Post-doctoral researcher, University of Warwick, School of Biology
2006-2008: Research Scientist, Public Health England, Porton Down
Education:
2008-2012: PhD Virology, The Pirbright Institute/The University of Warwick
2005-2006: MSc Molecular Biology and Pathology of Viruses: Imperial College, London
1999-2002: BSc (Hons) Microbiology and Virology, The University of Warwick
Professional memberships
Microbiology Society
Contact Details
BentleyK@cardiff.ac.uk
Henry Wellcome Building for Biomedical Research, Room 3F08, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN
Henry Wellcome Building for Biomedical Research, Room 3F08, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN