![Nicholas Bray](https://profiles-cardiff.imgix.net/attachments/637?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Nicholas Bray
Senior Lecturer, Division of Psychological Medicine and Clinical Neurosciences
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
My research investigates molecular mechanisms through which genetic variation confers risk to neuropsychiatric disorders.
Cyhoeddiad
2025
- Owen, M., Bray, N., Walters, J. and O'Donovan, M. 2025. Genomics of major mental illness. Nature Reviews Genetics
2024
- Tume, C. E., Chick, S. L., Holmans, P. A., Rees, E., O'Donovan, M. C., Cameron, D. and Bray, N. J. 2024. Genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. Biological Psychiatry 4(5), article number: 100345. (10.1016/j.bpsgos.2024.100345)
- Cameron, D. et al. 2024. Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia. Schizophrenia Bulletin Open 50(5), pp. 1171-1184. (10.1093/schbul/sbae083)
- Wen, C. et al. 2024. Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain. Science 384(6698), article number: eadh0829. (10.1126/science.adh0829)
2023
- Toste, C., O'Donovan, M. and Bray, N. 2023. Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits. Human Molecular Genetics 32(20), pp. 2941-2949., article number: ddad118. (10.1093/hmg/ddad118)
- Cameron, D. et al. 2023. Single nuclei RNA sequencing of 5 regions of the human prenatal brain implicates developing neuron populations in genetic risk for schizophrenia. Biological Psychiatry 93, pp. 157-166. (10.1016/j.biopsych.2022.06.033)
2022
- Trubetskoy, V. et al. 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604, pp. 502-508. (10.1038/s41586-022-04434-5)
- Hall, J. and Bray, N. J. 2022. Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?. Biological Psychiatry 91(8), pp. 709-717. (10.1016/j.biopsych.2021.10.018)
2021
- Kouakou, M., Cameron, D., Hannon, E., Dempster, E. L., Mill, J., Hill, M. J. and Bray, N. 2021. Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(6), pp. 376-388. (10.1002/ajmg.b.32877)
- Hrastelj, J. et al. 2021. CSF-resident CD4+ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis. Brain Communications (10.1093/braincomms/fcab155)
- Hall, L. S. et al. 2021. Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders. Molecular Psychiatry 26, pp. 2082-2088. (10.1038/s41380-020-0743-3)
- Steg, L. C. et al. 2021. Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Molecular Brain 14(1), article number: 98. (10.1186/s13041-021-00810-w)
- Leung, S. K. et al. 2021. Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Cell Reports 37(7), article number: 110022. (10.1016/j.celrep.2021.110022)
2020
- Grama, S. et al. 2020. Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort. Translational Psychiatry 10, article number: 309. (10.1038/s41398-020-00940-0)
- Bray, N. J. and Owen, M. J. 2020. A developmental perspective on the convergence of genetic risk factors for neuropsychiatric disorders. Biological Psychiatry 87(2), pp. 98-99. (10.1016/j.biopsych.2019.09.010)
- Hall, L. S. et al. 2020. A transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia. Human Molecular Genetics 29(1), pp. 159-167. (10.1093/hmg/ddz253)
2019
- Toste, C. et al. 2019. No effect of genome-wide significant schizophrenia risk variation at the DRD2 locus on the allelic expression of DRD2 in post-mortem striatum. Molecular Neuropsychiatry 5(4), pp. 212-217. (10.1159/000501022)
- Pain, O. et al. 2019. Novel insight into the etiology of autism spectrum disorder gained by integrating expression data with genome-wide association statistics. Biological Psychiatry 86(4), pp. 265-273. (10.1016/j.biopsych.2019.04.034)
- Duarte, R. R. et al. 2019. The psychiatric risk gene NT5C2 regulates adenosine monophosphate-activated protein kinase signaling and protein translation in human neural progenitor cells. Biological Psychiatry 86(2), pp. 120-130. (10.1016/j.biopsych.2019.03.977)
- Cameron, D., Blake, D. J., Bray, N. J. and Hill, M. J. 2019. Transcriptional changes following cellular knockdown of the schizophrenia risk gene SETD1A are enriched for common variant association with the disorder. Molecular Neuropsychiatry 5(2), pp. 109-114. (10.1159/000497181)
- O'Brien, H. et al. 2019. Sex differences in gene expression in the human fetal brain. [Online]. bioRxiv. (10.1101/483636) Available at: https://doi.org/10.1101/483636
2018
- O'Brien, H. E. et al. 2018. Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome Biology 19, article number: 194. (10.1186/s13059-018-1567-1)
- Bray, N. J. and O'Donovan, M. C. 2018. The genetics of neuropsychiatric disorders. Brain and Neuroscience Advances 2, pp. 1-6. (10.1177/2398212818799271)
2017
- Spiers, H., Hannon, E., Schalkwyk, L. C., Bray, N. and Mill, J. 2017. 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. BMC Genomics 18, pp. 738. (10.1186/s12864-017-4091-x)
- Deans, P. J. M. et al. 2017. Psychosis risk candidate ZNF804A localizes to synapses and regulates neurite formation and dendritic spine structure. Biological Psychiatry 82(1), pp. 49-61. (10.1016/j.biopsych.2016.08.038)
- Hannon, E., Weedon, M., Bray, N., O'Donovan, M. and Mill, J. 2017. Pleiotropic effects of trait-associated genetic variation on DNA methylation: utility for refining GWAS loci. American Journal of Human Genetics 100(6), pp. 954-959. (10.1016/j.ajhg.2017.04.013)
- Hill, M., Killick, R., Navarrete, K., Maruszak, A., McLaughlin, G., Williams, B. and Bray, N. J. 2017. Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex. Journal of Psychiatry & Neuroscience 42(3), pp. 181-188., article number: 160073. (10.1503/jpn.160073)
- Cosgrove, D. et al. 2017. MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls. Translational Psychiatry 7(1), pp. e1012. (10.1038/tp.2016.286)
2016
- Duarte, R. R., Troakes, C., Nolan, M., Srivastava, D. P., Murray, R. M. and Bray, N. J. 2016. Genome-wide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cis-regulation of BORCS7, AS3MT, and NT5C2 in the human brain. American Journal of Medical Genetics. Part B 171(6), pp. 806-814. (10.1002/ajmg.b.32445)
- Hannon, E. et al. 2016. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nature Neuroscience 19(1), pp. 48-54. (10.1038/nn.4182)
- Bray, N. J. and Hill, M. 2016. Translating genetic risk loci into molecular risk mechanisms for schizophrenia. Schizophrenia Bulletin 42(1), pp. 5-8. (10.1093/schbul/sbv156)
2015
- Spiers, H. et al. 2015. Methylomic trajectories across human fetal brain development. Genome Research 25(3), pp. 338-352. (10.1101/gr.180273.114)
2014
- Pidsley, R. et al. 2014. Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biology 15(10), article number: 483. (10.1186/s13059-014-0483-2)
- Hill, M. J., Donocik, J. G., Nuamah, R. A., Mein, C. A., Sainz-Fuertes, R. and Bray, N. J. 2014. Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells. Schizophrenia Research 153(1-3), pp. 225-230. (10.1016/j.schres.2014.01.034)
2012
- Hill, M. and Bray, N. J. 2012. Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development. American Journal of Psychiatry 169(12), pp. 1301-1308. (10.1176/appi.ajp.2012.11121845)
- Hill, M. J. and Bray, N. J. 2012. Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during foetal brain development. American Journal of Psychiatry 169(12), pp. 1301-1308.
- Bray, N. J., Kapur, S. and Price, J. 2012. Investigating schizophrenia in a "dish": possibilities, potential and limitations. World Psychiatry 11(3), pp. 153-155. (10.1002/j.2051-5545.2012.tb00116.x)
- Jeffries, A. R., Perfect, L. W., Ledderose, J., Schalkwyk, L. C., Bray, N. J., Mill, J. and Price, J. 2012. Stochastic choice of allelic expression in human neural stem cells. Stem Cells 30(9), pp. 1938-1947. (10.1002/stem.1155)
- Hill, M., Jeffries, A. R., Dobson, R. J. B., Price, J. and Bray, N. J. 2012. Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Human Molecular Genetics 21(5), pp. 1018-1024. (10.1093/hmg/ddr532)
2011
- Hill, M. and Bray, N. J. 2011. Allelic differences in nuclear protein binding at a genome-wide significant risk variant for schizophrenia in ZNF804A [Letter to the editor]. Molecular Psychiatry 16(8), pp. 787-789. (10.1038/mp.2011.21)
2010
- Bray, N. J., Leweke, F. M., Kapur, S. and Meyer-Lindenberg, A. 2010. The neurobiology of schizophrenia: new leads and avenues for treatment. Current Opinion in Neurobiology 20(6), pp. 810-815. (10.1016/j.conb.2010.09.008)
- Buonocore, F. et al. 2010. Effects of cis-regulatory variation differ across regions of the adult human brain. Human Molecular Genetics 19(22), pp. 4490-4496. (10.1093/hmg/ddq380)
2009
- Hayesmoore, J. B. G., Bray, N. J., Cross, W. C., Owen, M. J., O'Donovan, M. C. and Morris, H. R. 2009. The effect of age and the H1c MAPT haplotype on MAPT expression in human brain. Neurobiology of Aging 30(10), pp. 1652-1656. (10.1016/j.neurobiolaging.2007.12.017)
2008
- Hayesmoore, J. B., Bray, N. J., Owen, M. J. and O'Donovan, M. C. 2008. DISC1mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(7), pp. 1065-1069. (10.1002/ajmg.b.30715)
- Bray, N. J. 2008. Gene expression in the etiology of schizophrenia. Schizophrenia Bulletin 34(3), pp. 412-418. (10.1093/schbul/sbn013)
- Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17(8), pp. 1169-1174. (10.1093/hmg/ddn006)
2007
- O'Donovan, M. C. et al. 2007. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia [Conference Abstract]. Schizophrenia bulletin 33(2), pp. 311-312. (10.1093/schbul/sbm004)
2006
- Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(7), pp. 723-724.
- Georgieva, L. et al. 2006. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 103(33), pp. 12469-12474. (10.1073/pnas.0603029103)
- Bray, N. J. and O'Donovan, M. C. 2006. Investigating cis-acting regulatory variation using assays of relative allelic expression. Psychiatric Genetics 16(4), pp. 173-177. (10.1097/01.ypg.0000218612.35139.84)
- Peirce, T. R. et al. 2006. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of general psychiatry 63(1), pp. 18-24. (10.1001/archpsyc.63.1.18)
- Peirce, T. et al. 2006. Convergent evidence for 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of General Psychiatry 63(1), pp. 18-24.
- Norton, N. et al. 2006. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(1), pp. 96-101. (10.1002/ajmg.b.30236)
2005
- Bray, N. J., Preece, A. C., Williams, N. M., Escott-Price, V., Buckland, P. R., Owen, M. J. and O'Donovan, M. C. 2005. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Human Molecular Genetics 14(14), pp. 1947-1954. (10.1093/hmg/ddi199)
- Kent, L. et al. 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10(10), pp. 939-943. (10.1038/sj.mp.4001696)
- Glaser, B., Kirov, G., Bray, N. J., Green, E., O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2005. Identification of a potential Bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. Molecular Psychiatry 10(10), pp. 920-927. (10.1038/sj.mp.4001689)
2004
- Peirce, T. R. et al. 2004. Convergent functional genomics, association and linkage analysis suggests 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase (CNP) as a potential susceptibility gene for schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 81-81. (10.1002/ajmg.b.30101)
- Bray, N. J. et al. 2004. Allelic variation in the expression of neuropsychiatric candidate genes [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 25-25.
- Norton, N. et al. 2004. Interaction between neuregulin 1 and its receptor ERBB4 increases susceptibility to schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 18-18.
- Bray, N. J., Jehu, L., Escott-Price, V., Buckland, P. R., Williams, J., Owen, M. J. and O'Donovan, M. C. 2004. Allelic expression of APOE in brain [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 61-61.
- Bray, N. J., Jehu, L., Escott-Price, V., Buckland, P. R., Owen, M. J., Williams, J. and O'Donovan, M. C. 2004. P4-101 Allelic expression of APOE in brain [Conference Abstract]. Neurobiology of Aging 25, pp. S503-S503. (10.1016/S0197-4580(04)81659-2)
- Williams, N. M. et al. 2004. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Archives of General Psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
- Williams, N. M. et al. 2004. Identification in two independent samples of a novel schizophrenia risk haplotype of the dystobrevin binding protein gene (DTNBP1). Archives of general psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
- Bray, N. J., Buckland, P. R., Hall, H., Owen, M. J. and O'Donovan, M. C. 2004. The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Molecular Psychiatry 9(1), pp. 109-114. (10.1038/sj.mp.4001366)
- Bray, N. J. et al. 2004. Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes. Human Molecular Genetics 13(22), pp. 2885-2892. (10.1093/hmg/ddh299)
2003
- Bray, N. J., Buckland, P. R., Williams, N. M., Williams, H. J., Norton, N., Owen, M. J. and O'Donovan, M. C. 2003. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. The American Journal of Human Genetics 73(1), pp. 152-161. (10.1086/376578)
- Bray, N. B., Buckland, P. R., Owen, M. J. and O'Donovan, M. C. 2003. Cis-acting variation in the expression of a high proportion of genes in human brain. Human Genetics 113(2), pp. 149-153. (10.1007/s00439-003-0956-y)
2002
- Bray, N. J. et al. 2002. Screening the protocadherin 8 (PCDH8) gene in schizophrenia [Conference Abstract]. American Journal of Medical Genetics 114(7), pp. 844-844.
- Bray, N. J., Buckland, P. R., Williams, H., Norton, N., Williams, N. M., Owen, M. J. and O'Donovan, M. C. 2002. Detection of cis-acting polymorphisms and epigenetic modification affecting gene expression [Conference Abstracts]. American Journal of Medical Genetics 114(7), pp. 750-750. (10.1002/ajmg.10971)
- Bray, N. J. et al. 2002. Screening the human protocadherin 8 (PCDH8) gene in schizophrenia. Genes, Brain and Behavior 1(3), pp. 187-191. (10.1034/j.1601-183X.2002.10307.x)
2001
- Bray, N. J. and Owen, M. J. 2001. Searching for schizophrenia genes. Trends in Molecular Medicine 7(4), pp. 169-174.
2000
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Bray, N. J., Jacobsen, N., Spurlock, G., Austin, J., Williams, H. and Owen, M. J. 2000. A functional and positional candidate gene for schizophrenia. American Journal of Medical Genetics 96(4), pp. 461-462.
- Bray, N. J. et al. 2000. No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia. Psychiatric Genetics 10(2), pp. 83-86. (10.1097/00041444-200010020-00005)
1999
- Willliams, H., Bray, N. J., Murphy, K. C., Cardno, A. G., Jones, L. A. and Owen, M. J. 1999. No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH).. American Journal Of Medical Genetics Part A 88(5), pp. 557-559. (10.1002/(SICI)1096-8628(19991015)88:5<557::AID-AJMG22>3.0.CO;2-F)
- Norton, N. et al. 1999. No evidence for association between schizophrenia and MAO-A promoter polymorphism. Molecular Psychiatry 4, pp. S96-S96.
- Bray, N. J., Cardno, A. G., Fitzpatrick, E. R., Buckland, P. R. and Owen, M. J. 1999. Embryonic NCAM and schizophrenia: Genetic analysis of regulatory enzymes. Molecular Psychiatry 4, pp. S32-S32.
Articles
- Owen, M., Bray, N., Walters, J. and O'Donovan, M. 2025. Genomics of major mental illness. Nature Reviews Genetics
- Tume, C. E., Chick, S. L., Holmans, P. A., Rees, E., O'Donovan, M. C., Cameron, D. and Bray, N. J. 2024. Genetic implication of specific glutamatergic neurons of the prefrontal cortex in the pathophysiology of schizophrenia. Biological Psychiatry 4(5), article number: 100345. (10.1016/j.bpsgos.2024.100345)
- Cameron, D. et al. 2024. Genetic implication of prenatal GABAergic and cholinergic neuron development in susceptibility to schizophrenia. Schizophrenia Bulletin Open 50(5), pp. 1171-1184. (10.1093/schbul/sbae083)
- Wen, C. et al. 2024. Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain. Science 384(6698), article number: eadh0829. (10.1126/science.adh0829)
- Toste, C., O'Donovan, M. and Bray, N. 2023. Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits. Human Molecular Genetics 32(20), pp. 2941-2949., article number: ddad118. (10.1093/hmg/ddad118)
- Cameron, D. et al. 2023. Single nuclei RNA sequencing of 5 regions of the human prenatal brain implicates developing neuron populations in genetic risk for schizophrenia. Biological Psychiatry 93, pp. 157-166. (10.1016/j.biopsych.2022.06.033)
- Trubetskoy, V. et al. 2022. Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia. Nature 604, pp. 502-508. (10.1038/s41586-022-04434-5)
- Hall, J. and Bray, N. J. 2022. Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?. Biological Psychiatry 91(8), pp. 709-717. (10.1016/j.biopsych.2021.10.018)
- Kouakou, M., Cameron, D., Hannon, E., Dempster, E. L., Mill, J., Hill, M. J. and Bray, N. 2021. Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(6), pp. 376-388. (10.1002/ajmg.b.32877)
- Hrastelj, J. et al. 2021. CSF-resident CD4+ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis. Brain Communications (10.1093/braincomms/fcab155)
- Hall, L. S. et al. 2021. Cis-effects on gene expression in the human prenatal brain associated with genetic risk for neuropsychiatric disorders. Molecular Psychiatry 26, pp. 2082-2088. (10.1038/s41380-020-0743-3)
- Steg, L. C. et al. 2021. Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Molecular Brain 14(1), article number: 98. (10.1186/s13041-021-00810-w)
- Leung, S. K. et al. 2021. Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Cell Reports 37(7), article number: 110022. (10.1016/j.celrep.2021.110022)
- Grama, S. et al. 2020. Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort. Translational Psychiatry 10, article number: 309. (10.1038/s41398-020-00940-0)
- Bray, N. J. and Owen, M. J. 2020. A developmental perspective on the convergence of genetic risk factors for neuropsychiatric disorders. Biological Psychiatry 87(2), pp. 98-99. (10.1016/j.biopsych.2019.09.010)
- Hall, L. S. et al. 2020. A transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia. Human Molecular Genetics 29(1), pp. 159-167. (10.1093/hmg/ddz253)
- Toste, C. et al. 2019. No effect of genome-wide significant schizophrenia risk variation at the DRD2 locus on the allelic expression of DRD2 in post-mortem striatum. Molecular Neuropsychiatry 5(4), pp. 212-217. (10.1159/000501022)
- Pain, O. et al. 2019. Novel insight into the etiology of autism spectrum disorder gained by integrating expression data with genome-wide association statistics. Biological Psychiatry 86(4), pp. 265-273. (10.1016/j.biopsych.2019.04.034)
- Duarte, R. R. et al. 2019. The psychiatric risk gene NT5C2 regulates adenosine monophosphate-activated protein kinase signaling and protein translation in human neural progenitor cells. Biological Psychiatry 86(2), pp. 120-130. (10.1016/j.biopsych.2019.03.977)
- Cameron, D., Blake, D. J., Bray, N. J. and Hill, M. J. 2019. Transcriptional changes following cellular knockdown of the schizophrenia risk gene SETD1A are enriched for common variant association with the disorder. Molecular Neuropsychiatry 5(2), pp. 109-114. (10.1159/000497181)
- O'Brien, H. E. et al. 2018. Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome Biology 19, article number: 194. (10.1186/s13059-018-1567-1)
- Bray, N. J. and O'Donovan, M. C. 2018. The genetics of neuropsychiatric disorders. Brain and Neuroscience Advances 2, pp. 1-6. (10.1177/2398212818799271)
- Spiers, H., Hannon, E., Schalkwyk, L. C., Bray, N. and Mill, J. 2017. 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. BMC Genomics 18, pp. 738. (10.1186/s12864-017-4091-x)
- Deans, P. J. M. et al. 2017. Psychosis risk candidate ZNF804A localizes to synapses and regulates neurite formation and dendritic spine structure. Biological Psychiatry 82(1), pp. 49-61. (10.1016/j.biopsych.2016.08.038)
- Hannon, E., Weedon, M., Bray, N., O'Donovan, M. and Mill, J. 2017. Pleiotropic effects of trait-associated genetic variation on DNA methylation: utility for refining GWAS loci. American Journal of Human Genetics 100(6), pp. 954-959. (10.1016/j.ajhg.2017.04.013)
- Hill, M., Killick, R., Navarrete, K., Maruszak, A., McLaughlin, G., Williams, B. and Bray, N. J. 2017. Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex. Journal of Psychiatry & Neuroscience 42(3), pp. 181-188., article number: 160073. (10.1503/jpn.160073)
- Cosgrove, D. et al. 2017. MiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls. Translational Psychiatry 7(1), pp. e1012. (10.1038/tp.2016.286)
- Duarte, R. R., Troakes, C., Nolan, M., Srivastava, D. P., Murray, R. M. and Bray, N. J. 2016. Genome-wide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cis-regulation of BORCS7, AS3MT, and NT5C2 in the human brain. American Journal of Medical Genetics. Part B 171(6), pp. 806-814. (10.1002/ajmg.b.32445)
- Hannon, E. et al. 2016. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nature Neuroscience 19(1), pp. 48-54. (10.1038/nn.4182)
- Bray, N. J. and Hill, M. 2016. Translating genetic risk loci into molecular risk mechanisms for schizophrenia. Schizophrenia Bulletin 42(1), pp. 5-8. (10.1093/schbul/sbv156)
- Spiers, H. et al. 2015. Methylomic trajectories across human fetal brain development. Genome Research 25(3), pp. 338-352. (10.1101/gr.180273.114)
- Pidsley, R. et al. 2014. Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biology 15(10), article number: 483. (10.1186/s13059-014-0483-2)
- Hill, M. J., Donocik, J. G., Nuamah, R. A., Mein, C. A., Sainz-Fuertes, R. and Bray, N. J. 2014. Transcriptional consequences of schizophrenia candidate miR-137 manipulation in human neural progenitor cells. Schizophrenia Research 153(1-3), pp. 225-230. (10.1016/j.schres.2014.01.034)
- Hill, M. and Bray, N. J. 2012. Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development. American Journal of Psychiatry 169(12), pp. 1301-1308. (10.1176/appi.ajp.2012.11121845)
- Hill, M. J. and Bray, N. J. 2012. Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during foetal brain development. American Journal of Psychiatry 169(12), pp. 1301-1308.
- Bray, N. J., Kapur, S. and Price, J. 2012. Investigating schizophrenia in a "dish": possibilities, potential and limitations. World Psychiatry 11(3), pp. 153-155. (10.1002/j.2051-5545.2012.tb00116.x)
- Jeffries, A. R., Perfect, L. W., Ledderose, J., Schalkwyk, L. C., Bray, N. J., Mill, J. and Price, J. 2012. Stochastic choice of allelic expression in human neural stem cells. Stem Cells 30(9), pp. 1938-1947. (10.1002/stem.1155)
- Hill, M., Jeffries, A. R., Dobson, R. J. B., Price, J. and Bray, N. J. 2012. Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion. Human Molecular Genetics 21(5), pp. 1018-1024. (10.1093/hmg/ddr532)
- Hill, M. and Bray, N. J. 2011. Allelic differences in nuclear protein binding at a genome-wide significant risk variant for schizophrenia in ZNF804A [Letter to the editor]. Molecular Psychiatry 16(8), pp. 787-789. (10.1038/mp.2011.21)
- Bray, N. J., Leweke, F. M., Kapur, S. and Meyer-Lindenberg, A. 2010. The neurobiology of schizophrenia: new leads and avenues for treatment. Current Opinion in Neurobiology 20(6), pp. 810-815. (10.1016/j.conb.2010.09.008)
- Buonocore, F. et al. 2010. Effects of cis-regulatory variation differ across regions of the adult human brain. Human Molecular Genetics 19(22), pp. 4490-4496. (10.1093/hmg/ddq380)
- Hayesmoore, J. B. G., Bray, N. J., Cross, W. C., Owen, M. J., O'Donovan, M. C. and Morris, H. R. 2009. The effect of age and the H1c MAPT haplotype on MAPT expression in human brain. Neurobiology of Aging 30(10), pp. 1652-1656. (10.1016/j.neurobiolaging.2007.12.017)
- Hayesmoore, J. B., Bray, N. J., Owen, M. J. and O'Donovan, M. C. 2008. DISC1mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B(7), pp. 1065-1069. (10.1002/ajmg.b.30715)
- Bray, N. J. 2008. Gene expression in the etiology of schizophrenia. Schizophrenia Bulletin 34(3), pp. 412-418. (10.1093/schbul/sbn013)
- Bray, N. J. et al. 2008. Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1. Human Molecular Genetics 17(8), pp. 1169-1174. (10.1093/hmg/ddn006)
- O'Donovan, M. C. et al. 2007. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia [Conference Abstract]. Schizophrenia bulletin 33(2), pp. 311-312. (10.1093/schbul/sbm004)
- Bray, N. J. et al. 2006. Cis- and trans-acting loci influence expression of DTNBP1, a susceptibility gene for schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(7), pp. 723-724.
- Georgieva, L. et al. 2006. Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 103(33), pp. 12469-12474. (10.1073/pnas.0603029103)
- Bray, N. J. and O'Donovan, M. C. 2006. Investigating cis-acting regulatory variation using assays of relative allelic expression. Psychiatric Genetics 16(4), pp. 173-177. (10.1097/01.ypg.0000218612.35139.84)
- Peirce, T. R. et al. 2006. Convergent evidence for 2',3'-cyclic nucleotide 3'-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of general psychiatry 63(1), pp. 18-24. (10.1001/archpsyc.63.1.18)
- Peirce, T. et al. 2006. Convergent evidence for 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase as a possible susceptibility gene for schizophrenia. Archives of General Psychiatry 63(1), pp. 18-24.
- Norton, N. et al. 2006. Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 141B(1), pp. 96-101. (10.1002/ajmg.b.30236)
- Bray, N. J., Preece, A. C., Williams, N. M., Escott-Price, V., Buckland, P. R., Owen, M. J. and O'Donovan, M. C. 2005. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Human Molecular Genetics 14(14), pp. 1947-1954. (10.1093/hmg/ddi199)
- Kent, L. et al. 2005. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Molecular Psychiatry 10(10), pp. 939-943. (10.1038/sj.mp.4001696)
- Glaser, B., Kirov, G., Bray, N. J., Green, E., O'Donovan, M. C., Craddock, N. J. and Owen, M. J. 2005. Identification of a potential Bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4. Molecular Psychiatry 10(10), pp. 920-927. (10.1038/sj.mp.4001689)
- Peirce, T. R. et al. 2004. Convergent functional genomics, association and linkage analysis suggests 2 ',3 '-cyclic nucleotide 3 '-phosphodiesterase (CNP) as a potential susceptibility gene for schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 81-81. (10.1002/ajmg.b.30101)
- Bray, N. J. et al. 2004. Allelic variation in the expression of neuropsychiatric candidate genes [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 25-25.
- Norton, N. et al. 2004. Interaction between neuregulin 1 and its receptor ERBB4 increases susceptibility to schizophrenia [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 18-18.
- Bray, N. J., Jehu, L., Escott-Price, V., Buckland, P. R., Williams, J., Owen, M. J. and O'Donovan, M. C. 2004. Allelic expression of APOE in brain [Conference Abstract]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 130B(1), pp. 61-61.
- Bray, N. J., Jehu, L., Escott-Price, V., Buckland, P. R., Owen, M. J., Williams, J. and O'Donovan, M. C. 2004. P4-101 Allelic expression of APOE in brain [Conference Abstract]. Neurobiology of Aging 25, pp. S503-S503. (10.1016/S0197-4580(04)81659-2)
- Williams, N. M. et al. 2004. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Archives of General Psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
- Williams, N. M. et al. 2004. Identification in two independent samples of a novel schizophrenia risk haplotype of the dystobrevin binding protein gene (DTNBP1). Archives of general psychiatry 61(4), pp. 336-344. (10.1001/archpsyc.61.4.336)
- Bray, N. J., Buckland, P. R., Hall, H., Owen, M. J. and O'Donovan, M. C. 2004. The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Molecular Psychiatry 9(1), pp. 109-114. (10.1038/sj.mp.4001366)
- Bray, N. J. et al. 2004. Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes. Human Molecular Genetics 13(22), pp. 2885-2892. (10.1093/hmg/ddh299)
- Bray, N. J., Buckland, P. R., Williams, N. M., Williams, H. J., Norton, N., Owen, M. J. and O'Donovan, M. C. 2003. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. The American Journal of Human Genetics 73(1), pp. 152-161. (10.1086/376578)
- Bray, N. B., Buckland, P. R., Owen, M. J. and O'Donovan, M. C. 2003. Cis-acting variation in the expression of a high proportion of genes in human brain. Human Genetics 113(2), pp. 149-153. (10.1007/s00439-003-0956-y)
- Bray, N. J. et al. 2002. Screening the protocadherin 8 (PCDH8) gene in schizophrenia [Conference Abstract]. American Journal of Medical Genetics 114(7), pp. 844-844.
- Bray, N. J., Buckland, P. R., Williams, H., Norton, N., Williams, N. M., Owen, M. J. and O'Donovan, M. C. 2002. Detection of cis-acting polymorphisms and epigenetic modification affecting gene expression [Conference Abstracts]. American Journal of Medical Genetics 114(7), pp. 750-750. (10.1002/ajmg.10971)
- Bray, N. J. et al. 2002. Screening the human protocadherin 8 (PCDH8) gene in schizophrenia. Genes, Brain and Behavior 1(3), pp. 187-191. (10.1034/j.1601-183X.2002.10307.x)
- Bray, N. J. and Owen, M. J. 2001. Searching for schizophrenia genes. Trends in Molecular Medicine 7(4), pp. 169-174.
- Austin, J. et al. 2000. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. Molecular Psychiatry 5(5), pp. 552-557. (10.1038/sj.mp.4000761)
- Bray, N. J., Jacobsen, N., Spurlock, G., Austin, J., Williams, H. and Owen, M. J. 2000. A functional and positional candidate gene for schizophrenia. American Journal of Medical Genetics 96(4), pp. 461-462.
- Bray, N. J. et al. 2000. No evidence for association between a non-synonymous polymorphism in the gene encoding human metabotropic glutamate receptor 7 and schizophrenia. Psychiatric Genetics 10(2), pp. 83-86. (10.1097/00041444-200010020-00005)
- Willliams, H., Bray, N. J., Murphy, K. C., Cardno, A. G., Jones, L. A. and Owen, M. J. 1999. No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH).. American Journal Of Medical Genetics Part A 88(5), pp. 557-559. (10.1002/(SICI)1096-8628(19991015)88:5<557::AID-AJMG22>3.0.CO;2-F)
- Norton, N. et al. 1999. No evidence for association between schizophrenia and MAO-A promoter polymorphism. Molecular Psychiatry 4, pp. S96-S96.
- Bray, N. J., Cardno, A. G., Fitzpatrick, E. R., Buckland, P. R. and Owen, M. J. 1999. Embryonic NCAM and schizophrenia: Genetic analysis of regulatory enzymes. Molecular Psychiatry 4, pp. S32-S32.
Websites
- O'Brien, H. et al. 2019. Sex differences in gene expression in the human fetal brain. [Online]. bioRxiv. (10.1101/483636) Available at: https://doi.org/10.1101/483636
Ymchwil
Mae anhwylderau niwroseiciatrig, fel sgitsoffrenia, yn deillio o weithred miloedd o amrywiadau genetig ar y cyd â ffactorau amgylcheddol. Mae'r mwyafrif helaeth o loci genetig sy'n ymwneud yn gyffredin â'r anhwylderau hyn yn awgrymu rhanbarthau nad ydynt yn codio o'r genom ac felly credir eu bod yn effeithio ar reoleiddio genynnau (mynegiant genynnau a splicing). Mae fy ngrŵp yn cymhwyso amrywiaeth o dechnolegau genomig swyddogaethol i feinwe'r ymennydd dynol a chelloedd niwral i ymchwilio i effeithiau amrywiadau risg genetig ar reoleiddio genynnau a'u canlyniadau moleciwlaidd i lawr yr afon. Mae gennym ddiddordeb arbennig mewn beichiogrwydd fel cyfnod a allai fod yn bwysig ar gyfer bregusrwydd diweddarach i rai o'r anhwylderau hyn, ac yn ddiweddar rydym wedi cynhyrchu'r ymchwiliad genom cyntaf ledled y genom o effeithiau genetig ar fynegiant genynnau yn yr ymennydd cynenedigol dynol (O'Brien et al, 2018).
Addysgu
Rwy'n brofiadol mewn addysgu ar lefel israddedig ac ôl-raddedig ac rwy'n Gymrawd yr Academi Addysg Uwch.
Bywgraffiad
Yn dilyn BSc mewn Seicoleg (Llundain) ac MSc mewn Niwrowyddoniaeth (Llundain), enillais PhD (archwilio genynnau sy'n ymwneud â datblygu'r ymennydd fel ymgeiswyr ar gyfer tueddiad sgitsoffrenia) dan oruchwyliaeth Mike Owen yng Nghaerdydd. Roedd fy ymchwil ôl-ddoethurol, a gynhaliwyd yng Nghaerdydd gyda Mick O'Donovan, yn canolbwyntio ar fynegiant genynnau fel cyfryngwr posibl o risg genetig ar gyfer anhwylderau seiciatrig. Cefais fy mhenodi'n Ddarlithydd yn y Sefydliad Seiciatreg, Coleg y Brenin Llundain, yn 2006 a chefais fy nyrchafu yn Uwch-ddarlithydd yn 2012. Dychwelais i Brifysgol Caerdydd yn 2015, lle rwyf bellach yn Athro ac yn Arweinydd Rhanbarthol ar gyfer Ymchwil Ôl-raddedig.
Contact Details
BrayN3@caerdydd.ac.uk
+44 29206 88368
Adeilad Hadyn Ellis, Ystafell 2.51, Heol Maendy, Caerdydd, CF24 4HQ
+44 29206 88368
Adeilad Hadyn Ellis, Ystafell 2.51, Heol Maendy, Caerdydd, CF24 4HQ