![Ian Brewis](https://profiles-cardiff.imgix.net/attachments/7950?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Trosolwyg
Mae fy mhrif rôl yng Nghaerdydd yn cynnwys seilwaith ymchwil a rheoli cyfleusterau craidd (0.9 cyfwerth ag amser llawn, FTE). Mae gen i hefyd rai cyfrifoldebau addysgu a rheoli addysgu (0.1 FTE).
Rwy'n Arweinydd / Cadeirydd Academaidd Grŵp Goruchwylio Seilwaith Ymchwil yr Ysgol Feddygaeth (RIOG) ac mae gen i ystod o gyfrifoldebau rheoli seilwaith ymchwil ar lefel Ysgol a Choleg. Y tu hwnt i Gaerdydd fi yw Cynrychiolydd Arweinyddiaeth Dechnegol Prifysgol Caerdydd Grŵp Llywio Seilwaith Ymchwil a Chynaliadwyedd GW4*, cyn Gadeirydd ac Aelod Sylfaenol y Grŵp. Rwyf hefyd yn Aelod o Gyngor Gweithredol CTLS**, yn Aelod o Weithgor Hyfforddi ac yn gyn Arweinydd Grŵp Ffocws Cysgodi a Chyfnewid Staff.
*Mae Cynghrair GW4 yn bartneriaeth ymchwil gydweithredol rhwng Prifysgolion Caerfaddon, Bryste, Caerdydd a Chaerwysg (https://gw4.ac.uk/).
**Mae Technolegau Craidd ar gyfer Gwyddorau Bywyd (CTLS) yn gymdeithas rwydweithio pan-Ewropeaidd ar gyfer y rhai sy'n gweithio mewn cyfleusterau craidd, seilwaith ymchwil a labordai adnoddau a rennir eraill (https://ctls-org.eu/)
Rwyf wedi bod yn Gyfarwyddwr Gweithredol y Gwasanaethau Biotechnoleg Canolog (CBS) ers Rhagfyr 2011. Mae CBS (https://www.cardiff.ac.uk/central-biotechnology-services) yn gyfleuster technoleg craidd sydd wedi'i ardystio gan ISO 9001:2015 ac sydd wedi'i achredu gan Ymarfer Labordy Clinigol Da (GCLP) ym Mhrifysgol Caerdydd. Wedi'i leoli yn yr Ysgol Feddygaeth, mae CBS yn darparu mynegiant genynnau a biowybodeg, proteinau a diagnosteg a llwyfannau dadansoddi/delweddu celloedd, gwasanaethau, hyfforddiant ac arbenigedd i ymchwilwyr lleol a sefydliadau allanol. Mae CBS hefyd yn cynnig cyfleoedd i gwmnïau cynnal a gall ddarparu cyfleusterau labordy, cymorth technolegol, ymgynghoriaeth academaidd a mynediad at ystod eang o adnoddau prifysgol eraill. Mae opsiynau ar gyfer ymchwil contract a gwasanaethau a reolir yn cael eu hategu gan hanes profedig o weithio gyda sefydliadau nid-er-elw, busnesau newydd, busnesau bach a chanolig a busnesau mawr.
Gweler yr adran Addysgu am fy nghyfrifoldebau addysgu/rheoli addysgu.
Cyhoeddiad
2021
- Alsagaby, S. A. et al. 2021. Proteomics-based identification of cancer-associated proteins in chronic lymphocytic leukaemia. Electronic Journal of Biotechnology 52, pp. 1-12. (10.1016/j.ejbt.2021.04.006)
2017
- Brewis, I., Watkinson, M. and Von Ruhland, C. 2017. Heads you win, tails you lose: filtration processing for the microscopical examination of sperm heads. Journal of Microscopy 265(3), pp. 335-340. (10.1111/jmi.12505)
2016
- Webber, J. P., Spary, L. K., Mason, M. D., Tabi, Z., Brewis, I. A. and Clayton, A. 2016. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget 7, pp. 20124-20139. (10.18632/oncotarget.7716)
2014
- Webber, J. et al. 2014. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscanTM) platform. Molecular and Cellular Proteomics 13(4), pp. 1050-1064. (10.1074/mcp.M113.032136)
- Alsagaby, S. A. et al. 2014. Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia. Journal of Proteome Research 13(11), pp. 5051-5062. (10.1021/pr5002803)
2012
- Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
- Tsai, P. J., Brewis, I. A., van Maaren, J. and Gadella, B. M. 2012. Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis. Plos One 7(3), article number: e32603. (10.1371/journal.pone.0032603)
2011
- Sexton, K. J., Balharry, D. C., Brennan, P., McLaren, J. E., Brewis, I. A. and Berube, K. A. 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16(7), pp. 567-576. (10.3109/1354750X.2011.608855)
2010
- Welton, J. L. et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9(6), pp. 1324-1338. (10.1074/mcp.M000063-MCP201)
- Brewis, I. and Brennan, P. 2010. Proteomics technologies for the global identification and quantification of proteins. In: Donev, R. ed. Advances in Protein Chemistry and Structural Biology., Vol. 80. Elsevier, pp. 1-44., (10.1016/B978-0-12-381264-3.00001-1)
- Alnagar, F., Brennan, P. and Brewis, I. A. 2010. Bicarbonate-dependent serine/threonine protein dephosphorylation in capacitating boar spermatozoa. Journal of Andrology 31(4), pp. 393-405. (10.2164/jandrol.109.008383)
- Brewis, I. A. and Topley, N. 2010. Proteomics and peritoneal dialysis: early days but clear potential. Nephrology Dialysis Transplantation 25(6), pp. 1749-1753. (10.1093/ndt/gfq145)
2009
- Brennan, P. et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3(3), pp. 359-369. (10.1002/prca.200800137)
2007
- Brewis, I. A., Gadella, B., Ashton, P. R. and Gestel, R. A. v. 2007. Multiple proteins present in purified porcine sperm apical plasma membranes interact with the zona pellucida of the oocyte. Molecular Human Reproduction 13(7), pp. 445-454. (10.1093/molehr/gam030)
- Brewis, I. A. 2007. Protein chips and disease biomarkers. Plasma Protein Monitor 1, pp. 47-48.
- Brewis, I. A. 2007. The way forward for clinical proteomics. Plasma Protein Monitor 1, pp. 55-56.
- Connor, S. J. et al. 2007. Understanding the physiology of pre-fertilisation events in the human spermatozoa - a necessary prerequisite to developing rational therapy. Society of Reproduction and Fertility Supplement 63, pp. 237-255.
2006
- Brewis, I. A. 2006. The human plasma proteome. Plasma Protein Monitor 1, pp. 39-40.
2005
- Brewis, I. A., Gadella, B. M., Ashton, P. R. and Gestal, R. A. v. 2005. Capacitation-dependent concentration of lipid rafts in the apical ridge head area of porcine sperm cells. Molecular Human Reproduction 11(8), pp. 583-590. (10.1093/molehr/gah200)
- Moseley, F. L. C., Jha, K. N., Björndahl, L., Brewis, I. A., Publicover, S. J., Barratt, C. L. R. and Lefièvre, L. 2005. Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation. Molecular Human Reproduction 11(7), pp. 523-529. (10.1093/molehr/gah188)
- Brewis, I. A. 2005. Proteomics – possibilities and pitfalls. Plasma Protein Monitor 1, pp. 22-23.
- Brewis, I. A. et al. 2005. Molecular mechanisms during sperm capacitation. Human Fertility 8(4), pp. 253-261. (10.1080/14647270500420178)
- Brewis, I. A. et al. 2005. The spermatozoon at fertilisation: Current understanding and future research directions. Human Fertility 8(4), pp. 241-251. (10.1080/14647270500420160)
2004
- Kilani, Z., Ismail, R., Ghunaim, S., Mohamed, H., Hughes, D., Brewis, I. A. and Barratt, C. L. R. 2004. Evaluation and treatment of familial globozoospermia in five brothers. Fertility and Sterility 82(5), pp. 1436-1439. (10.1016/j.fertnstert.2004.03.064)
- Brewis, I. A., Barratt, C., Deeks, E. D. and Flesch, F. M. 2004. Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: case report. Human Reproduction 19(6), pp. 1438-1447. (10.1093/humrep/deh224)
- Lefievre, L. et al. 2004. Four zona pellucida glycoproteins are expressed in the human. Human Reproduction 19(7), pp. 1580-1586. (10.1093/humrep/deh301)
2003
- Lefièvre, L. et al. 2003. Physiological and proteomic approaches to studying prefertilization events in the human. Reproductive BioMedicine Online 7(4), pp. 419-427. (10.1016/S1472-6483(10)61885-8)
2002
- Ivic, A. et al. 2002. Critical evaluation of methylcellulose as an alternative medium in sperm migration tests. Human Reproduction 17(1), pp. 143-149. (10.1093/humrep/17.1.143)
- Barratt, C. L., Hughes, D. C., Afnan, M. and Brewis, I. A. 2002. Functional genomics in reproductive medicine. Human Fertility 5(1), pp. 3-5., article number: 10.1080/1464727992000199681.
2001
- Brewis, I. A., England, G. C. W., Moore, H. D. M. and Morton, I. E. 2001. Solubilized zona pellucida proteins and progesterone induce calcium influx and the acrosome reaction in capacitated dog spermatozoa. Molecular Reproduction and Development 60(4), pp. 491-497. (10.1002/mrd.1114)
- Hosseinzadeh, S., Brewis, I. A., Eley, A. and Pacey, A. A. 2001. Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death. Human Reproduction 16(2), pp. 293-299. (10.1093/humrep/16.2.293)
2000
- Hosseinzadeh, S., Brewis, I. A., Pacey, A. A., Moore, H. D. M. and Eley, A. 2000. Coincubation of human spermatozoa with chlamydia trachomatis in vitro causes increased tyrosine phosphorylation of sperm proteins. Infection and Immunity 68(9), pp. 4872-4876. (10.1128/IAI.68.9.4872-4876.2000)
- Brewis, I., Morton, I. E., Mohammad, S. N., Browes, C. E. and Moore, H. D. 2000. Measurement of intracellular calcium concentration and plasma membrane potential in human spermatozoa using flow cytometry. Journal of Andrology 21(2), pp. 238-249. (10.1002/j.1939-4640.2000.tb02101.x)
1999
- Brewis, I. A. and Wong, C. H. 1999. Gamete recognition: sperm proteins that interact with the egg zona pellucida. Reproduction 4(3), pp. 135-142. (10.1530/ror.0.0040135)
- Brewis, I. A. 1999. Proteomics in reproductive research: The potential importance of proteomics to research in reproduction. Human Reproduction 14(12), pp. 2927-2929. (10.1093/humrep/14.12.2927)
1998
- Moore, H. D., Samayawardhena, L. A. and Brewis, I. A. 1998. Sperm maturation in vitro: co-culture of spermatozoa and epididymal epithelium. Journal of Reproduction and Fertility. Supplement 53, pp. 23-31.
- Fisher, H. M., Brewis, I. A., Barratt, C. L., Cooke, I. D. and Moore, H. D. 1998. Phosphoinositide 3-kinase is involved in the induction of the human sperm acrosome reaction downstream of tyrosine phosphorylation. Molecular Human Reproduction 4(9), pp. 849-855. (10.1093/molehr/4.9.849)
- Brewis, I. A. 1998. Tyrosine phosphorylation of a 95 kDa protein and induction of the acrosome reaction in human spermatozoa by recombinant human zona pellucida glycoprotein 3. Molecular Human Reproduction 4(12), pp. 1136-1144. (10.1093/molehr/4.12.1136)
1997
- Brewis, I. A. and Moore, H. D. 1997. Molecular mechanisms of gamete recognition and fusion at fertilization. Human Reproduction 12(Sup.), pp. 156-165.
1996
- Brewis, I. A., Clayton, R., Barratt, C. L. R., Hornby, D. P. J. and Moore, H. D. M. 1996. Recombinant human zona pellucida glycoprotein 3 induces calcium influx and acrosome reaction in human spermatozoa. Molecular Human Reproduction 2(8), pp. 583-589. (10.1093/molehr/2.8.583)
1995
- Brewis, I. A., Ferguson, M. A. J., Mehlert, A., Turner, A. J. and Hooper, N. M. 1995. Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase: comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures. Journal of Biological Chemistry 270(39), pp. 22946-22956. (10.1074/jbc.270.39.22946)
1994
- Brewis, I. A., Turner, A. J. and Hooper, N. M. 1994. Activation of the glycosyl-phosphatidylinositol-anchored membrane dipeptidase upon release from pig kidney membranes by phospholipase C. Biochemical Journal -London- 303, pp. 633-638.
- Leese, H. J., Brewis, I. A., Edwards, L. I., Gray, S. M., Skiera, L. S. and Winston, R. M. L. 1994. Biochemistry of tubal secretions. In: Grudzinskas, J. G. et al. eds. The Fallopian Tube: clinical and surgical aspects. London: Springer, pp. 53-62.
1993
- Howell, S., Brewis, I. A., Hooper, N. M., Kenny, A. J. and Turner, A. J. 1993. Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells. FEBS Letters 317(1-2), pp. 109-112. (10.1016/0014-5793(93)81502-Q)
- Brewis, I. A., Ferguson, M. A., Turner, A. J. and Hooper, N. M. 1993. Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases. Biochemical Society Transactions 21(1), pp. 46S-46S. (10.1042/bst021046s)
- Brewis, I., Howell, S., Hooper, N. M., Kenny, A. J. and Turner, A. J. 1993. Membrane peptidase expression by confluent cultures of Caco-2 cells. Biochemical Society Transactions 21, pp. 252S-252S. (10.1042/bst021252s)
- Brewis, I. A., Hooper, N. M. and Turner, A. J. 1993. Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase. Biochemical Society Transactions 21, pp. 44S-44S. (10.1042/bst021044s)
1992
- Brewis, I. A., Winston, R. M. L. and Leese, H. J. 1992. Energy metabolism of the human Fallopian tube. Reproduction 95(1), pp. 257-262. (10.1530/jrf.0.0950257)
Adrannau llyfrau
- Brewis, I. and Brennan, P. 2010. Proteomics technologies for the global identification and quantification of proteins. In: Donev, R. ed. Advances in Protein Chemistry and Structural Biology., Vol. 80. Elsevier, pp. 1-44., (10.1016/B978-0-12-381264-3.00001-1)
- Leese, H. J., Brewis, I. A., Edwards, L. I., Gray, S. M., Skiera, L. S. and Winston, R. M. L. 1994. Biochemistry of tubal secretions. In: Grudzinskas, J. G. et al. eds. The Fallopian Tube: clinical and surgical aspects. London: Springer, pp. 53-62.
Erthyglau
- Alsagaby, S. A. et al. 2021. Proteomics-based identification of cancer-associated proteins in chronic lymphocytic leukaemia. Electronic Journal of Biotechnology 52, pp. 1-12. (10.1016/j.ejbt.2021.04.006)
- Brewis, I., Watkinson, M. and Von Ruhland, C. 2017. Heads you win, tails you lose: filtration processing for the microscopical examination of sperm heads. Journal of Microscopy 265(3), pp. 335-340. (10.1111/jmi.12505)
- Webber, J. P., Spary, L. K., Mason, M. D., Tabi, Z., Brewis, I. A. and Clayton, A. 2016. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget 7, pp. 20124-20139. (10.18632/oncotarget.7716)
- Webber, J. et al. 2014. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscanTM) platform. Molecular and Cellular Proteomics 13(4), pp. 1050-1064. (10.1074/mcp.M113.032136)
- Alsagaby, S. A. et al. 2014. Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia. Journal of Proteome Research 13(11), pp. 5051-5062. (10.1021/pr5002803)
- Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24(14), pp. 966-975. (10.3109/08958378.2012.742600)
- Tsai, P. J., Brewis, I. A., van Maaren, J. and Gadella, B. M. 2012. Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis. Plos One 7(3), article number: e32603. (10.1371/journal.pone.0032603)
- Sexton, K. J., Balharry, D. C., Brennan, P., McLaren, J. E., Brewis, I. A. and Berube, K. A. 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16(7), pp. 567-576. (10.3109/1354750X.2011.608855)
- Welton, J. L. et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9(6), pp. 1324-1338. (10.1074/mcp.M000063-MCP201)
- Alnagar, F., Brennan, P. and Brewis, I. A. 2010. Bicarbonate-dependent serine/threonine protein dephosphorylation in capacitating boar spermatozoa. Journal of Andrology 31(4), pp. 393-405. (10.2164/jandrol.109.008383)
- Brewis, I. A. and Topley, N. 2010. Proteomics and peritoneal dialysis: early days but clear potential. Nephrology Dialysis Transplantation 25(6), pp. 1749-1753. (10.1093/ndt/gfq145)
- Brennan, P. et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3(3), pp. 359-369. (10.1002/prca.200800137)
- Brewis, I. A., Gadella, B., Ashton, P. R. and Gestel, R. A. v. 2007. Multiple proteins present in purified porcine sperm apical plasma membranes interact with the zona pellucida of the oocyte. Molecular Human Reproduction 13(7), pp. 445-454. (10.1093/molehr/gam030)
- Brewis, I. A. 2007. Protein chips and disease biomarkers. Plasma Protein Monitor 1, pp. 47-48.
- Brewis, I. A. 2007. The way forward for clinical proteomics. Plasma Protein Monitor 1, pp. 55-56.
- Connor, S. J. et al. 2007. Understanding the physiology of pre-fertilisation events in the human spermatozoa - a necessary prerequisite to developing rational therapy. Society of Reproduction and Fertility Supplement 63, pp. 237-255.
- Brewis, I. A. 2006. The human plasma proteome. Plasma Protein Monitor 1, pp. 39-40.
- Brewis, I. A., Gadella, B. M., Ashton, P. R. and Gestal, R. A. v. 2005. Capacitation-dependent concentration of lipid rafts in the apical ridge head area of porcine sperm cells. Molecular Human Reproduction 11(8), pp. 583-590. (10.1093/molehr/gah200)
- Moseley, F. L. C., Jha, K. N., Björndahl, L., Brewis, I. A., Publicover, S. J., Barratt, C. L. R. and Lefièvre, L. 2005. Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation. Molecular Human Reproduction 11(7), pp. 523-529. (10.1093/molehr/gah188)
- Brewis, I. A. 2005. Proteomics – possibilities and pitfalls. Plasma Protein Monitor 1, pp. 22-23.
- Brewis, I. A. et al. 2005. Molecular mechanisms during sperm capacitation. Human Fertility 8(4), pp. 253-261. (10.1080/14647270500420178)
- Brewis, I. A. et al. 2005. The spermatozoon at fertilisation: Current understanding and future research directions. Human Fertility 8(4), pp. 241-251. (10.1080/14647270500420160)
- Kilani, Z., Ismail, R., Ghunaim, S., Mohamed, H., Hughes, D., Brewis, I. A. and Barratt, C. L. R. 2004. Evaluation and treatment of familial globozoospermia in five brothers. Fertility and Sterility 82(5), pp. 1436-1439. (10.1016/j.fertnstert.2004.03.064)
- Brewis, I. A., Barratt, C., Deeks, E. D. and Flesch, F. M. 2004. Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: case report. Human Reproduction 19(6), pp. 1438-1447. (10.1093/humrep/deh224)
- Lefievre, L. et al. 2004. Four zona pellucida glycoproteins are expressed in the human. Human Reproduction 19(7), pp. 1580-1586. (10.1093/humrep/deh301)
- Lefièvre, L. et al. 2003. Physiological and proteomic approaches to studying prefertilization events in the human. Reproductive BioMedicine Online 7(4), pp. 419-427. (10.1016/S1472-6483(10)61885-8)
- Ivic, A. et al. 2002. Critical evaluation of methylcellulose as an alternative medium in sperm migration tests. Human Reproduction 17(1), pp. 143-149. (10.1093/humrep/17.1.143)
- Barratt, C. L., Hughes, D. C., Afnan, M. and Brewis, I. A. 2002. Functional genomics in reproductive medicine. Human Fertility 5(1), pp. 3-5., article number: 10.1080/1464727992000199681.
- Brewis, I. A., England, G. C. W., Moore, H. D. M. and Morton, I. E. 2001. Solubilized zona pellucida proteins and progesterone induce calcium influx and the acrosome reaction in capacitated dog spermatozoa. Molecular Reproduction and Development 60(4), pp. 491-497. (10.1002/mrd.1114)
- Hosseinzadeh, S., Brewis, I. A., Eley, A. and Pacey, A. A. 2001. Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death. Human Reproduction 16(2), pp. 293-299. (10.1093/humrep/16.2.293)
- Hosseinzadeh, S., Brewis, I. A., Pacey, A. A., Moore, H. D. M. and Eley, A. 2000. Coincubation of human spermatozoa with chlamydia trachomatis in vitro causes increased tyrosine phosphorylation of sperm proteins. Infection and Immunity 68(9), pp. 4872-4876. (10.1128/IAI.68.9.4872-4876.2000)
- Brewis, I., Morton, I. E., Mohammad, S. N., Browes, C. E. and Moore, H. D. 2000. Measurement of intracellular calcium concentration and plasma membrane potential in human spermatozoa using flow cytometry. Journal of Andrology 21(2), pp. 238-249. (10.1002/j.1939-4640.2000.tb02101.x)
- Brewis, I. A. and Wong, C. H. 1999. Gamete recognition: sperm proteins that interact with the egg zona pellucida. Reproduction 4(3), pp. 135-142. (10.1530/ror.0.0040135)
- Brewis, I. A. 1999. Proteomics in reproductive research: The potential importance of proteomics to research in reproduction. Human Reproduction 14(12), pp. 2927-2929. (10.1093/humrep/14.12.2927)
- Moore, H. D., Samayawardhena, L. A. and Brewis, I. A. 1998. Sperm maturation in vitro: co-culture of spermatozoa and epididymal epithelium. Journal of Reproduction and Fertility. Supplement 53, pp. 23-31.
- Fisher, H. M., Brewis, I. A., Barratt, C. L., Cooke, I. D. and Moore, H. D. 1998. Phosphoinositide 3-kinase is involved in the induction of the human sperm acrosome reaction downstream of tyrosine phosphorylation. Molecular Human Reproduction 4(9), pp. 849-855. (10.1093/molehr/4.9.849)
- Brewis, I. A. 1998. Tyrosine phosphorylation of a 95 kDa protein and induction of the acrosome reaction in human spermatozoa by recombinant human zona pellucida glycoprotein 3. Molecular Human Reproduction 4(12), pp. 1136-1144. (10.1093/molehr/4.12.1136)
- Brewis, I. A. and Moore, H. D. 1997. Molecular mechanisms of gamete recognition and fusion at fertilization. Human Reproduction 12(Sup.), pp. 156-165.
- Brewis, I. A., Clayton, R., Barratt, C. L. R., Hornby, D. P. J. and Moore, H. D. M. 1996. Recombinant human zona pellucida glycoprotein 3 induces calcium influx and acrosome reaction in human spermatozoa. Molecular Human Reproduction 2(8), pp. 583-589. (10.1093/molehr/2.8.583)
- Brewis, I. A., Ferguson, M. A. J., Mehlert, A., Turner, A. J. and Hooper, N. M. 1995. Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase: comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures. Journal of Biological Chemistry 270(39), pp. 22946-22956. (10.1074/jbc.270.39.22946)
- Brewis, I. A., Turner, A. J. and Hooper, N. M. 1994. Activation of the glycosyl-phosphatidylinositol-anchored membrane dipeptidase upon release from pig kidney membranes by phospholipase C. Biochemical Journal -London- 303, pp. 633-638.
- Howell, S., Brewis, I. A., Hooper, N. M., Kenny, A. J. and Turner, A. J. 1993. Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells. FEBS Letters 317(1-2), pp. 109-112. (10.1016/0014-5793(93)81502-Q)
- Brewis, I. A., Ferguson, M. A., Turner, A. J. and Hooper, N. M. 1993. Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases. Biochemical Society Transactions 21(1), pp. 46S-46S. (10.1042/bst021046s)
- Brewis, I., Howell, S., Hooper, N. M., Kenny, A. J. and Turner, A. J. 1993. Membrane peptidase expression by confluent cultures of Caco-2 cells. Biochemical Society Transactions 21, pp. 252S-252S. (10.1042/bst021252s)
- Brewis, I. A., Hooper, N. M. and Turner, A. J. 1993. Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase. Biochemical Society Transactions 21, pp. 44S-44S. (10.1042/bst021044s)
- Brewis, I. A., Winston, R. M. L. and Leese, H. J. 1992. Energy metabolism of the human Fallopian tube. Reproduction 95(1), pp. 257-262. (10.1530/jrf.0.0950257)
Ymchwil
Gweler yr adran Bywgraffiad am fanylion y cyn-actifiaeth hon
Addysgu
Mae fy mhrif rolau rheoli addysgu/addysgu yn cynnwys:-
-Cyn Gyfarwyddwr Rhaglen MSc Biowybodeg/Epidemioleg Genetig a Biowybodeg (2010-2016)
-Arweinydd Modiwl ar gyfer y modiwl MSc Biowybodeg Gymhwysol a Genomeg (MSc Biowybodeg gynt) Bioleg Protein ac Omics (Biowybodeg Protein gynt) (ers 2004)
-Arweinydd Tiwtor Personol ar gyfer y Rhaglen MSc Biowybodeg Gymhwysol a Genomeg (MSc Biowybodeg gynt) (ers 2024) a Thiwtor Personol (ers 2004 ac fel arfer 5 myfyriwr)
-Tiwtor Personol ar gyfer myfyrwyr meddygol MBBCh (C21) (ers 2013 ac fel arfer 10 myfyriwr)
-Ysgol Feddygaeth C21 Arweinydd Addysgu Rhanbarthol ar gyfer Arloesedd Clinigol (ers 2016)
-Cynrychiolydd Ymchwil Ôl-raddedig (PGR) ar gyfer Arloesedd Clinigol (nid addysgu'n llym ond wedi'i gynnwys yma gan ei fod hefyd yn weithgaredd addysgol) (ers 2016)
-Arholwr Allanol ar gyfer pum Rhaglen Meistr a Addysgir mewn tair Prifysgol Grŵp Russell (2012-2020) ac ar gyfer llawer o draethodau gradd ymchwil (13 traethawd PhD a 2 MRes)
-Adolygydd Allanol ar gyfer pedair Rhaglen Meistr newydd (2012-2024) ac un Rhaglen Israddedig newydd (2025) mewn dwy Brifysgol Grŵp Russell
-Darlithydd Cyswllt yn y Brifysgol Agored (2010-2017 yn fy amser fy hun)
Bywgraffiad
Gweler yr adran Trosolwg ar gyfer fy rolau presennol.
Cefais fy recriwtio i Gaerdydd yn 2003 a chefais y dasg o sicrhau cyllid i sefydlu ac arwain Cyfleuster Proteomeg newydd. Roedd hyn yn llwyddiannus ac, fel Arweinydd Academaidd Cyfleuster Proteomeg CBS, roeddwn yn gyfrifol am ystod eang o brosiectau mewn cydweithrediadau estynedig gyda llawer o ymchwilwyr Caerdydd a chleientiaid allanol tan 2014. Roeddwn hefyd yn Gyfarwyddwr Gwyddonol Ovasort Ltd, a oedd â diddordeb yn bennaf mewn dewis rhyw sberm mewn da byw (2005-2009).
Rwy'n gyn-ymchwilydd (nodweddiad proteomig a swyddogaethol celloedd sberm mamalaidd wrth ffrwythloni) ac roeddwn yn Olygydd Cyswllt ar gyfer dau gyfnodol: Molecular Human Reproduction (2013-2016) ac Atproduction (2013-2023). Cyn Caerdydd roeddwn yn Uwch Gymrawd Ymchwil yn Uned Beichiogi â Chymorth y GIG Prifysgol Birmingham a Birmingham (2000-2003) ac yn Gydymaith Ymchwil Ôl-ddoethurol yn Uned Beichiogi â Chymorth y GIG ym Mhrifysgol Birmingham a Birmingham (2000-2003) ac yn Gydymaith Ymchwil Ôl-ddoethurol yn y Prifysgol Sheffield (1993-2000). Roedd y rolau amrywiol hyn hefyd yn cynnwys ystod eang o brosiectau ymchwil yn atgenhedlu mamalaidd a sawl blwyddyn yn gweithio ar brosiectau masnachol.
Cynhaliwyd fy PhD (1994) ar fiocemeg angorau glycolipid mamalaidd fel Cynorthwyydd Ymchwilym Mhrifysgol Leeds ac roedd hefyd yn golygu treulio amser estynedig gyda chydweithwyr ym Mhrifysgol Dundee . Cyn hyn roeddwn yn Gynorthwyydd Ymchwil ym Mhrifysgol Efrog (1989-1990) lle ymchwiliais i fiocemeg tiwb Fallopaidd mewn cydweithrediad â chydweithwyr yn Ysbyty Hammersmith. Yn olaf, astudiais hefyd ar gyfer fy ngradd gyntaf ym Mhrifysgol Efrog a graddiais yn 1989 gyda BSc (Anrh) mewn Bioleg (Bioleg Celloedd a Biocemeg).
Meysydd goruchwyliaeth
Nid wyf yn ymchwil weithredol felly nid wyf ar gael i oruchwylio
Ymgysylltu
Gweler yr adran Trosolwg
Contact Details
BrewisIA@caerdydd.ac.uk
+44 29206 88648
Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ystafell UG11, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
+44 29206 88648
Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ystafell UG11, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
Themâu ymchwil
Arbenigeddau
- Seilwaith ymchwil cynaliadwy a rheoli cyfleusterau