Dr Ian Brewis

2026

• Rappoport, J. Z. et al., 2026. Community-based professional development in core facilities: ABRF and CTLS case studies. Journal of Biomolecular Techniques JBT 37 (3), pp.27-37. (10.7171/001c.166059)

2021

• Alsagaby, S. A. et al. 2021. Proteomics-based identification of cancer-associated proteins in chronic lymphocytic leukaemia. Electronic Journal of Biotechnology 52 , pp.1-12. (10.1016/j.ejbt.2021.04.006)

2017

• Brewis, I. , Watkinson, M. and Von Ruhland, C. 2017. Heads you win, tails you lose: filtration processing for the microscopical examination of sperm heads. Journal of Microscopy 265 (3), pp.335-340. (10.1111/jmi.12505)

2016

• Webber, J. P. et al. 2016. Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget 7 , pp.20124-20139. (10.18632/oncotarget.7716)

2014

• Webber, J. et al. 2014. Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscanTM) platform. Molecular and Cellular Proteomics 13 (4), pp.1050-1064. (10.1074/mcp.M113.032136)
• Alsagaby, S. A. et al., 2014. Proteomics-based strategies to identify proteins relevant to chronic lymphocytic leukemia. Journal of Proteome Research 13 (11), pp.5051-5062. (10.1021/pr5002803)

2012

• Tsai, P. J. et al., 2012. Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis. Plos One 7 (3) e32603.. (10.1371/journal.pone.0032603)
• Hoogendoorn, B. et al. 2012. Gene and protein responses of human lung tissue explants exposed to ambient particulate matter of different sizes. Inhalation Toxicology 24 (14), pp.966-975. (10.3109/08958378.2012.742600)

2011

• Sexton, K. J. et al. 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16 (7), pp.567-576. (10.3109/1354750X.2011.608855)

2010

• Welton, J. L. et al. 2010. Proteomics analysis of bladder cancer exosomes. Molecular & Cellular Proteomics 9 (6), pp.1324-1338. (10.1074/mcp.M000063-MCP201)
• Alnagar, F. , Brennan, P. and Brewis, I. A. 2010. Bicarbonate-dependent serine/threonine protein dephosphorylation in capacitating boar spermatozoa. Journal of Andrology 31 (4), pp.393-405. (10.2164/jandrol.109.008383)
• Brewis, I. and Brennan, P. 2010. Proteomics technologies for the global identification and quantification of proteins. In: Donev, R. ed. Advances in Protein Chemistry and Structural Biology. Vol. 80, Elsevier. , pp.1-44. (10.1016/B978-0-12-381264-3.00001-1)
• Brewis, I. A. and Topley, N. 2010. Proteomics and peritoneal dialysis: early days but clear potential. Nephrology Dialysis Transplantation 25 (6), pp.1749-1753. (10.1093/ndt/gfq145)

2009

• Brennan, P. et al. 2009. Quantitative nuclear proteomics reveals new phenotypes altered in lymphoblastoid cells. Proteomics - Clinical Applications 3 (3), pp.359-369. (10.1002/prca.200800137)

2007

• Brewis, I. A. et al. 2007. Multiple proteins present in purified porcine sperm apical plasma membranes interact with the zona pellucida of the oocyte. Molecular Human Reproduction 13 (7), pp.445-454. (10.1093/molehr/gam030)
• Brewis, I. A. 2007. Protein chips and disease biomarkers. Plasma Protein Monitor 1 , pp.47-48.
• Brewis, I. A. 2007. The way forward for clinical proteomics. Plasma Protein Monitor 1 , pp.55-56.
• Connor, S. J. et al., 2007. Understanding the physiology of pre-fertilisation events in the human spermatozoa - a necessary prerequisite to developing rational therapy. Society of Reproduction and Fertility Supplement 63 , pp.237-255.

2006

• Brewis, I. A. 2006. The human plasma proteome. Plasma Protein Monitor 1 , pp.39-40.

2005

• Brewis, I. A. et al. 2005. Capacitation-dependent concentration of lipid rafts in the apical ridge head area of porcine sperm cells. Molecular Human Reproduction 11 (8), pp.583-590. (10.1093/molehr/gah200)
• Brewis, I. A. 2005. Proteomics – possibilities and pitfalls. Plasma Protein Monitor 1 , pp.22-23.
• Brewis, I. A. et al. 2005. Molecular mechanisms during sperm capacitation. Human Fertility 8 (4), pp.253-261. (10.1080/14647270500420178)
• Brewis, I. A. et al. 2005. The spermatozoon at fertilisation: Current understanding and future research directions. Human Fertility 8 (4), pp.241-251. (10.1080/14647270500420160)
• Moseley, F. L. C. et al., 2005. Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation. Molecular Human Reproduction 11 (7), pp.523-529. (10.1093/molehr/gah188)

2004

• Brewis, I. A. et al. 2004. Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: case report. Human Reproduction 19 (6), pp.1438-1447. (10.1093/humrep/deh224)
• Kilani, Z. et al., 2004. Evaluation and treatment of familial globozoospermia in five brothers. Fertility and Sterility 82 (5), pp.1436-1439. (10.1016/j.fertnstert.2004.03.064)
• Lefievre, L. et al., 2004. Four zona pellucida glycoproteins are expressed in the human. Human Reproduction 19 (7), pp.1580-1586. (10.1093/humrep/deh301)

2003

• Lefièvre, L. et al., 2003. Physiological and proteomic approaches to studying prefertilization events in the human. Reproductive BioMedicine Online 7 (4), pp.419-427. (10.1016/S1472-6483(10)61885-8)

2002

• Barratt, C. L. et al., 2002. Functional genomics in reproductive medicine. Human Fertility 5 (1), pp.3-5. 10.1080/1464727992000199681.
• Ivic, A. et al., 2002. Critical evaluation of methylcellulose as an alternative medium in sperm migration tests. Human Reproduction 17 (1), pp.143-149. (10.1093/humrep/17.1.143)

2001

• Brewis, I. A. et al. 2001. Solubilized zona pellucida proteins and progesterone induce calcium influx and the acrosome reaction in capacitated dog spermatozoa. Molecular Reproduction and Development 60 (4), pp.491-497. (10.1002/mrd.1114)
• Hosseinzadeh, S. et al., 2001. Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death. Human Reproduction 16 (2), pp.293-299. (10.1093/humrep/16.2.293)

2000

• Brewis, I. et al. 2000. Measurement of intracellular calcium concentration and plasma membrane potential in human spermatozoa using flow cytometry. Journal of Andrology 21 (2), pp.238-249. (10.1002/j.1939-4640.2000.tb02101.x)
• Hosseinzadeh, S. et al., 2000. Coincubation of human spermatozoa with chlamydia trachomatis in vitro causes increased tyrosine phosphorylation of sperm proteins. Infection and Immunity 68 (9), pp.4872-4876. (10.1128/IAI.68.9.4872-4876.2000)

1999

• Brewis, I. A. 1999. Proteomics in reproductive research: The potential importance of proteomics to research in reproduction. Human Reproduction 14 (12), pp.2927-2929. (10.1093/humrep/14.12.2927)
• Brewis, I. A. and Wong, C. H. 1999. Gamete recognition: sperm proteins that interact with the egg zona pellucida. Reproduction 4 (3), pp.135-142. (10.1530/ror.0.0040135)

1998

• Brewis, I. A. 1998. Tyrosine phosphorylation of a 95 kDa protein and induction of the acrosome reaction in human spermatozoa by recombinant human zona pellucida glycoprotein 3. Molecular Human Reproduction 4 (12), pp.1136-1144. (10.1093/molehr/4.12.1136)
• Fisher, H. M. et al., 1998. Phosphoinositide 3-kinase is involved in the induction of the human sperm acrosome reaction downstream of tyrosine phosphorylation. Molecular Human Reproduction 4 (9), pp.849-855. (10.1093/molehr/4.9.849)
• Moore, H. D. , Samayawardhena, L. A. and Brewis, I. A. 1998. Sperm maturation in vitro: co-culture of spermatozoa and epididymal epithelium. Journal of Reproduction and Fertility. Supplement 53 , pp.23-31.

1997

• Brewis, I. A. and Moore, H. D. 1997. Molecular mechanisms of gamete recognition and fusion at fertilization. Human Reproduction 12 (Sup.), pp.156-165.

1996

• Brewis, I. A. et al. 1996. Recombinant human zona pellucida glycoprotein 3 induces calcium influx and acrosome reaction in human spermatozoa. Molecular Human Reproduction 2 (8), pp.583-589. (10.1093/molehr/2.8.583)

1995

• Brewis, I. A. et al. 1995. Structures of the glycosyl-phosphatidylinositol anchors of porcine and human renal membrane dipeptidase: comprehensive structural studies on the porcine anchor and interspecies comparison of the glycan core structures. Journal of Biological Chemistry 270 (39), pp.22946-22956. (10.1074/jbc.270.39.22946)

1994

• Brewis, I. A. , Turner, A. J. and Hooper, N. M. 1994. Activation of the glycosyl-phosphatidylinositol-anchored membrane dipeptidase upon release from pig kidney membranes by phospholipase C. Biochemical Journal -London- 303 , pp.633-638.
• Leese, H. J. et al., 1994. Biochemistry of tubal secretions. In: Grudzinskas, J. G. et al., The Fallopian Tube: clinical and surgical aspects. London: Springer. , pp.53-62.

1993

• Brewis, I. et al. 1993. Membrane peptidase expression by confluent cultures of Caco-2 cells. Biochemical Society Transactions 21 , pp.252S-252S. (10.1042/bst021252s)
• Brewis, I. A. et al. 1993. Structural determination of the glycolipid anchors of human and porcine membrane dipeptidases. Biochemical Society Transactions 21 (1), pp.46S-46S. (10.1042/bst021046s)
• Brewis, I. A. , Hooper, N. M. and Turner, A. J. 1993. Identification of the site of attachment of the glycolipid anchor in porcine membrane dipeptidase. Biochemical Society Transactions 21 , pp.44S-44S. (10.1042/bst021044s)
• Howell, S. et al., 1993. Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells. FEBS Letters 317 (1-2), pp.109-112. (10.1016/0014-5793(93)81502-Q)

1992

• Brewis, I. A. , Winston, R. M. L. and Leese, H. J. 1992. Energy metabolism of the human Fallopian tube. Reproduction 95 (1), pp.257-262. (10.1530/jrf.0.0950257)